Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| a novel interaction between the human papillomavirus type 16 e2 and e1--e4 proteins leads to stabilization of e2. | the e4 (also called e1--e4) and e2 proteins of human papillomavirus type 16 are thought to be expressed within the same cells of a lesion, and their open reading frames overlap, suggesting that they may have a functional relationship. we have examined the effect of co-expression of these two proteins and found that each enhances the level of the other. we also identified the n-terminus of e2 as the first example of a viral protein that directly binds the hpv16 e1--e4 protein. this appears to res ... | 2009 | 19783272 |
| correlates of cervicovaginal human papillomavirus detection in perimenopausal women. | the aim of this research was to determine correlates of prevalent cervicovaginal human papillomavirus (hpv) infection in perimenopausal women. | 2009 | 19702476 |
| koilocytes indicate a role for human papilloma virus in breast cancer. | high-risk human papilloma viruses (hpvs) are candidates as causal viruses in breast cancer. the scientific challenge is to determine whether hpvs are causal and not merely passengers or parasites. studies of hpv-related koilocytes in breast cancer offer an opportunity to address this crucial issue. koilocytes are epithelial cells characterised by perinuclear haloes surrounding condensed nuclei and are commonly present in cervical intraepithelial neoplasia. koilocytosis is accepted as pathognomon ... | 2009 | 19773762 |
| investigation of the occurrence of torque tenovirus in malignant and potentially malignant disorders associated with human papillomavirus. | in a previous pilot study, a significantly poorer outcome of laryngeal cancer was found in patients co-infected with human papillomavirus (hpv) and genogroup 1 torque tenovirus (ttv). the present study aimed to collect data on the overall prevalence of ttvs on the prevalence of genogroup 1 ttv in two other malignancies associated with hpv, oral squamous cell cancer and cervical cancer, and in oral and cervical premalignant lesions (oral lichen planus, oral leukoplakia, cervical atypia). oral sam ... | 2009 | 19774682 |
| [vaccination strategies against hpv. recommendations from a european perspective]. | most countries in western europe have recommended human papillomavirus (hpv) vaccination for the prevention of cervical cancer. the burden of cervical cancer remains high worldwide with regional differences in incidence rates and mortality. due to varying conditions in health care systems and nationwide data in the individual european countries, there are slightly different cervical cancer prevention strategies. there is an overall consensus to monitor the public health impact of hpv vaccines. d ... | 2009 | 19760369 |
| human papillomavirus type 16 exists in bacteria isolated from cervical cancer biopsies. | this study investigated the association between infectious microbes and persistent infection with human papillomavirus type 16 (hpv-16) in cervical cancer. bacterial strains (identified as enterococcus, staphylococcus, bacillus and corynebacterium, based on their partial 16s rdna sequence) were hpv-16 positive from 12 out of 14 cervical cancer biopsies. total dna was isolated from the four bacterial strains, and hpv-16 genes and genome were detected using polymerase chain reaction (pcr) and sout ... | 2009 | 19761689 |
| ethnic differences in human papillomavirus awareness and vaccine acceptability. | studies of human papillomavirus (hpv) awareness and hpv vaccine acceptability have included few non-white participants, making it difficult to explore ethnic differences. this study assessed hpv awareness and hpv vaccine acceptability in a sample of women representing the major uk ethnic minority groups. | 2009 | 19762455 |
| [hpv immunization for the prevention of cervical cancer]. | human papillomaviruses (hpv) infect epithelial cells of the skin and mucosae. mucosal high-risk hpv types (mainly hpv 16 and 18) are involved in the development of cervical cancer, one of the most common cancers in young women. hpv infection is usually asymptomatic and clears spontaneously, but 10 - 15 % of high-risk hpv infections are persistent and increase the risk of precancerous and cancerous lesions of the cervix. two hpv vaccines have been licensed to provide protection against cervical c ... | 2009 | 19765945 |
| prevalence of human papillomavirus (hpv) dna in oral mucosa of men with anogenital hpv infection. | the aim of the present study was to determine the prevalence of concurrent oral and anogenital human papillomavirus (hpv) infection in male patients using polymerase chain reaction and reverse hybridization. | 2009 | 19766023 |
| [production of human papillomavirus type 16 virus-like particles and its immunogenicity]. | hpv16 l1 gene was amplified from hpv16 positive vaginal secretion sample by pcr, and inserted into pto-t7 to obtain the recombinant expression vector pto-t7-hpv16-l1. then, the pto-t7-hpv16-l1 was transformed into e. coil strain er2566 and the recombinant protein hpv16 l1 was expressed in soluble form. after purification by ammonium sulfate precipitation, ion-exchange chromatography, and hydrophobic interaction chromatography, the recombinant protein hpv16 l1 had a purity of more than 98%. by re ... | 2009 | 19769155 |
| human papillomavirus dna detected in peripheral blood samples from healthy australian male blood donors. | recent studies have shown that human papillomavirus (hpv) dna can be found in circulating blood, including peripheral blood mononuclear cells (pbmcs), sera, plasma, and arterial cord blood. in light of these findings, dna extracted from pbmcs from healthy blood donors were examined in order to determine how common hpv dna is in blood of healthy individuals. blood samples were collected from 180 healthy male blood donors (18-76 years old) through the australian red cross blood services. genomic d ... | 2009 | 19697401 |
| compulsory licenses: a tool to improve global access to the hpv vaccine? | cervical cancer disproportionately affects women in lower- and middle-income countries. but the new vaccines developed to prevent infection with some strains of the human papillomavirus (hpv) that cause cervical cancer are priced beyond the reach of most women and health agencies in these regions, due in part to the monopoly pricing power of brand-name companies that hold the patents on the vaccines. compulsory licenses, which authorize generic competition with patented products, could expand ac ... | 2009 | 19697752 |
| overcoming barriers and ensuring access to hpv vaccines in low-income countries. | the inequitable burden of cervical cancer falls on women in poorer countries, due primarily to a disparity in access to screening services. to ensure that access to the new human papillomavirus ("hpv") vaccines is not similarly skewed toward higher-income populations, it is important to understand the appropriate priority group for receiving vaccines, the potential barriers to reaching that group, and the options for overcoming those barriers. based on vaccine efficacy data, the likelihood of ac ... | 2009 | 19697756 |
| [preinvasive vulvar and cervical cancer in a 32-year-old woman, dna hpv 16 positive with mtdna mutation--case study]. | coincidence of preinvasive vulvar and cervical cancer in young women is very rare. lesions like vin 3/preinvasive vulvar cancer and cin 3/preinvasive cervical cancer are strictly connected with viral infection and are multilocular. in the presented case the following tests have been performed: hpv dna test for the presence of 13 oncogenic hpv types, mrna hpv test for the presence of transcripts for hpv 16, 18, 31, 33, 45 and the analysis of mtdna d-loop region. in the examined patient hpv 16 inf ... | 2009 | 19697819 |
| health systems and immunization financing for human papillomavirus vaccine introduction in low-resource settings. | this descriptive qualitative study synthesizes health system and immunization financing assessments performed through formative research in india, peru, uganda, and vietnam using a non-probability sample of national and sub-national stakeholders; and recommends appropriate and effective strategies for hpv vaccine delivery in low-resource settings. we conclude that maximum feasibility and acceptability and lowest cost for delivering hpv vaccine can be achieved by implementing through national imm ... | 2009 | 19698808 |
| challenges, lessons learned and results following the implementation of a human papilloma virus school vaccination program in south australia. | to describe the process and challenges in the roll out of a large cervical cancer vaccination program to protect against human papilloma virus (hpv) infection. | 2009 | 19689598 |
| human papillomavirus types 16 and 18 dna load in relation to coexistence of other types, particularly those in the same species. | infection with multiple human papillomavirus (hpv) types is common. however, it is unknown whether viral dna load is related to the coexistence of other types. | 2009 | 19690188 |
| marketing hpv vaccine: implications for adolescent health and medical professionalism. | the new vaccine against 4 types of human papillomavirus (hpv), gardasil, like other immunizations appears to be a cost-effective intervention with the potential to enhance both adolescent health and the quality of their adult lives. however, the messages and the methods by which the vaccine was marketed present important challenges to physician practice and medical professionalism. by making the vaccine's target disease cervical cancer, the sexual transmission of hpv was minimized, the threat of ... | 2009 | 19690311 |
| value of high-risk hpv-dna testing in the triage of ascus. | objective. atypical squamous cells of undetermined significance (ascus) cells, occurring in organized cytological screening, may be either high-risk human papillomavirus (hpv) positive or negative. to refine the assessment of women with ascus, a high-risk hpv-dna test is recommended as triage in sweden. | 2009 | 19690991 |
| what's next? perspectives and future needs of cervical screening in europe in the era of molecular testing and vaccination. | to outline the perspectives for future control of cervical cancer in europe. | 2009 | 19695870 |
| human papillomavirus type-distribution in cervical cancer in china: the importance of hpv 16 and 18. | prophylactic vaccination against hpv 16 and 18 has the potential for effective prevention of high-grade precancer (cervical intraepithelial neoplasia [cin)] 2/3) and icc caused by these viruses (globally 50 and 70%, respectively) when employed in women prior to starting sexual activity. to provide data for decisions on hpv vaccination in china, we determined hpv type-distribution in icc and cin 2/3 from women of different regions within china. a multicenter study was conducted by randomized samp ... | 2009 | 19705288 |
| human papillomavirus 16 e7 oncoprotein attenuates dna damage checkpoint control by increasing the proteolytic turnover of claspin. | the human papillomavirus (hpv) 16 e7 oncoprotein has been reported previously to stimulate dna damage and to activate host cell dna damage checkpoints. how hpv-16 e7 maintains proliferation despite activated dna damage checkpoints is incompletely understood. here, we provide evidence that cells expressing the hpv-16 e7 oncoprotein can enter mitosis in the presence of dna damage. we show that this activity of hpv-16 e7 involves attenuation of dna damage checkpoint control by accelerating the prot ... | 2009 | 19706760 |
| [analysis of the etiological structure of sexually transmitted infections and immunological responsiveness in women with papillomavirus infection of the cervix uteri]. | two sexually transmitted infections or more were more frequently encountered in persistent papillomavirus infection (pvi) than those in transient pvi. the found immunological parameters in pvi arrested further infection progression, suppressed the persistence of human papillomavirus infection types 16 and 18, and prevented related cancer. this might eliminate the virus from the body. | 2009 | 19708554 |
| field methylation silencing of the protocadherin 10 gene in cervical carcinogenesis as a potential specific diagnostic test from cervical scrapings. | pcdh10 is a member of the protocadherin cell adhesion molecule family, which are frequently downregulated in cancers. this study aimed to characterize the methylation silencing of the pcdh10 gene in the full spectrum of cervical carcinogenesis and to clarify if a field effect of methylation might be a target for a diagnostic test from cervical scrapings. methylation silencing of pcdh10 was found in four of five cervical cancers and one of two cervical precancerous cell lines, which could be reve ... | 2009 | 19709077 |
| pigmented wart due to human papilloma virus type 60 showing parallel ridge pattern in dermoscopy. | 2009 | 19709979 | |
| monitoring of long-term effects of resveratrol on cell cycle progression of human hela cells after administration of a single dose. | expression of the human papillomavirus-encoded oncoproteins e6 and e7 in human hela cervical carcinoma cells results in their escape from the proper control of the cell cycle progression. therefore, their susceptibility to agents modulating cell cycle differs from that in cells in which the control of cell cycle regulation is intact. recently, a number of experimental studies revealed that polyphenols, especially resveratrol, could exert a strong antiproliferative effect. polyphenols (e.g., resv ... | 2009 | 19723063 |
| human hsp70 and modified hpv16 e7 fusion dna vaccine induces enhanced specific cd8+ t cell responses and anti-tumor effects. | cervical cancer is one of the most common cancers in women worldwide and persistent infection with human papilloma virus (hpv)s is considered to be the major risk factor. millions of women are currently infected with high risk genotypes. therefore, it is imperative to develop therapeutic vaccines to eliminate established infection or hpv-related disease. in the current study, we generated two potential therapeutic hpv dna vaccines, sigme7/mthsp70 and sigme7/huhsp70, using human and mycobacterium ... | 2009 | 19724878 |
| prevalence, viral load, and physical status of hpv 16 and 18 in cervical adenosquamous carcinoma. | adenosquamous carcinoma of the uterine cervix is a rare mixture of malignant squamous and glandular epithelial elements and accounts for approximately 10% of cervical carcinomas. the aims of the present study were to evaluate the prevalence, physical status, and viral load of hpv 16 and 18 in adenosquamous carcinoma. formalin-fixed paraffin-embedded tissue samples from 20 cases of histologically diagnosed adenosquamous carcinoma were examined. the squamous and glandular components were separatel ... | 2009 | 19727809 |
| human papilloma virus tests of normal cervical smears collected prior to the development of squamous carcinoma: a pilot study. | 2009 | 19734981 | |
| identification of hla-a11-restricted ctl epitopes derived from hpv type 18 using dna immunization. | identification of the cytotoxic t lymphocyte (ctl) epitopes of tumor antigens is important for effective immunotherapy. we report that a combination of epitope prediction, enzyme-linked immunosorbent assay (elisa)-based epitope-hla complex formation, and dna immunization methods can improve the efficiency and accuracy of ctl epitope studies. in this study, two hla-a11-restricted epitopes derived from human papillomavirus (hpv)18 e6 oncoprotein were identified. hla-a11-transgenic mice immunized w ... | 2009 | 19738415 |
| development and psychometric properties of the hpv impact profile (hip) to assess the psychosocial burden of hpv. | a comprehensive questionnaire designed to assess the full spectrum of potential human papillomavirus (hpv)-related psychosocial effects in women does not exist. the hpv impact profile (hip) was developed to determine the psychosocial impact of hpv infection and related interventions. | 2009 | 19739938 |
| coadministration of the fungal immunomodulatory protein fip-fve and a tumour-associated antigen enhanced antitumour immunity. | fve is a fungal protein isolated from the golden needle mushroom flammulina velutipes and has previously been reported to trigger immunological responses in both mouse and human lymphocytes. in this study, we evaluated the potential application of fve as an adjuvant for tumour immunotherapy and examined the underlying mechanism(s). when the human papillomavirus (hpv)-16 e7 oncoprotein was used as a model antigen, mice coimmunized with hpv-16 e7 and fve showed enhanced production of hpv-16 e7-spe ... | 2009 | 19740349 |
| genotype distribution of cervical human papillomavirus dna in women with cervical lesions in bioko, equatorial guinea. | the hvp vaccine is a useful tool for preventing cervical cancer. the purpose of this study is to determine the most frequent hpv genotypes in equatorial guinea in order to develop future vaccination strategies to apply in this country. | 2009 | 19740435 |
| human papillomavirus (hpv) type 18 induces extended growth in primary human cervical, tonsillar, or foreskin keratinocytes more effectively than other high-risk mucosal hpvs. | mucosal high-risk (hr) human papillomaviruses (hpvs) that cause cervical and other anogenital cancers also are found in approximately 25% of head and neck carcinomas (hncs), especially those arising in the oropharynx and the tonsils. while many hr hpv types are common in anogenital cancer, over 90% of hpv-positive hncs harbor hpv type 16 (hpv-16). using a quantitative colony-forming assay, we compared the ability of full-length mucosal hpv genomes, i.e., the low-risk hpv-11 and hr hpv-16, -18, a ... | 2009 | 19740985 |
| the current state of head and neck cancer gene therapy. | the incidence of head and neck cancer continues to increase worldwide, with tobacco exposure and human papillomavirus type 16 infections being the major etiological factors. current therapeutic options are ineffective in approximately half of the individuals afflicted with this malignancy. developments in the identification of molecules that sustain head and neck squamous cell carcinoma (hnscc) growth and survival have made molecular targeting by gene therapy approaches a feasible therapeutic st ... | 2009 | 19747066 |
| high-risk human papillomavirus testing for monitoring patients treated for high-grade cervical intraepithelial neoplasia. | the aim of the present study was to examine the accuracy of high-risk human papillomavirus (hr-hpv) dna detection as a predictor of residual or recurrent cervical intraepithelial neoplasia (cin) after treatment of high-grade cin. | 2009 | 19751331 |
| singaporean women's knowledge of human papillomavirus (hpv) and attitudes toward hpv vaccination. | with a vaccination program currently planned to protect singaporean women from human papillomavirus, a need arises for assessing singaporean women's knowledge of human papillomavirus and attitudes toward human papillomavirus vaccination to identify barriers to a successful program and to help inform health education campaigns. a representative sample of 2,145 women aged between 18 and 49 years were randomly selected from households throughout singapore and interviewed with a similar questionnair ... | 2009 | 19753508 |
| brief report: measuring the attitudes of health care professionals in dane county toward adolescent immunization with hpv vaccine. | evaluate regional health care professionals' views of human papillomavirus (hpv) vaccination recommendations for adolescent patients through a mailed survey. | 2009 | 19753828 |
| update on sexually transmitted infections, 2008. | sexually transmitted infections (stis) continue to be a great concern in the adolescent population and of particular concern to the pediatric emergency medicine physician. the centers for disease control and prevention reports that rates of gonorrheal and chlamydial infections are greatest in female adolescents, aged 15 to 19 years, and many people acquire human papilloma virus and human immunodeficiency virus infections during their teenage years. adolescents continue to be at a higher risk for ... | 2009 | 19755904 |
| [giant condyloma of the penis with malignant transformation associated with lichen sclerosus et atrophicus]. | a 72-year old patient presented with a 6 months history of a rapidly growing tumor of the glans and foreskin. he had a long history of phimosis with lichen sclerosus et atrophicus-like lesions on the foreskin which had not been treated. the rest of the personal, family and sexual history was unremarkable. treatment consists of circumcision and tumor excision. histopathology confirmed a squamous cell carcinoma within a giant condyloma with a concomitant lichen sclerosus et atrophicus. ct- and ult ... | 2009 | 19756435 |
| management of anal squamous intraepithelial lesions. | anal squamous intraepithelial lesions include both low-grade squamous intraepithelial lesions (lsil) and high-grade squamous intraepithelial lesions (hsil) and are caused by chronic infection with the human papillomavirus (hpv). the disease is increasing in both incidence and prevalence, especially among patients with the following risk factors: homosexual men, acquired or iatrogenic immunosuppression, and presence of other hpv-related diseases. although the natural history of the disease is unk ... | 2009 | 20436833 |
| clinical trials in the management of anal cancer. | our understandings of anal canal cancer pathogenesis and treatment have undergone significant changes due to continuing research into its pathogenesis and the results of major clinical trials conducted over the past 20 years. anal canal cancer can be cured by combined modality chemoradiation therapy, a treatment that preserves continence and reserves abdominoperineal resection of the rectum and anal canal in patients with recurrent or residual disease after primary chemoradiotherapy. the researc ... | 2009 | 20436836 |
| the relationship between hpv16 and hpv18 viral load and cervical lesions progression. | cervical cancer remains one of the most important mortality causes worldwide. it is already known that high risk hpv (hr-hpv) has the main role in the development of pre- or cancerous lesions. despite the fact that many studies focused on the hr-hpv viral loads as possible biomarkers, the viral load quantification utility for all hr-hpv genotypes is still a controversy. the purpose of our study was to determine if hpv16 and 18 viral load values might be a potential marker for hpv infection clear ... | 2009 | 20361539 |
| [detection of regulatory protein p16/ink4a in the dysplastic cervical squamous cell epithelium is a diagnostic tool for carcinoma prevention]. | parallel sections from 423 randomly selected blocks representing biopsies of 178 women with the diagnosis of cervical dysplasia and/or erosion were stained for p16 polypeptide. the p16/ink4a (inhibitory kinase 4) protein is a cellular division regulator, expression of which increases in the presence of oncoprotein e7, encoded by human papillomavirus (hpv). expression of p16 protein was seen in the nuclei and cytoplasm of dysplastic squamous epithelium cells as well as in carcinoma cells. in 16.6 ... | 2009 | 20301837 |
| developments in therapeutic human papillomavirus vaccination. | much progress has been made in the prevention and therapy of premalignant and malignant dysplasia caused by human papillomavirus by encouraging screening programs and recently by introducing preventive vaccines. to further reduce the worldwide burden of hpv-associated cancer supplementation of the established therapies with immunotherapeutic methods would have the potential for significant impact. dysplastic epithelial lesions and cancer of the anogenital and the oropharyngeal region show strong ... | 2009 | 20218099 |
| detection of 14 human papillomavirus genotypes in cervical samples in women from a central-southern area of italy showing different pap test results. | we evaluated the prevalence of human papillomavirus (hpv) infection and correlated the molecular test results with the cytological examination data (pap test) in 364 women living in central-southern italy (molise region), by means of polymerase chain reaction hpv dna genotyping and of cervical cytology. one hundred and twenty-eight women resulted hpv positive (35.2%), hpv16 being the most frequent genotype. hpv positive women were significantly younger than negative patients (35.9 +/- 8.4 years ... | 2009 | 20128441 |
| high genotyping concordance between the digene hpv genotyping rh test and the reverse line blot genotyping assay on gp5+/6+-pcr products. | based on epidemiologic studies, 18 mucosal human papillomavirus (hpv) types have been classified as (probably) high-risk (hr) (i.e., hpv 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, and 82). recognition of hr hpv at the individual type level may be valuable in clinical management of hr hpv-positive women. | 2009 | 20129069 |
| risk-adapted primary hpv cervical cancer screening project in wolfsburg, germany--experience over 3 years. | currently, the german cervical cancer screening program encompasses an annual cytological papanicolaou (pap) smear. however, primary screening for cervical cancer using human papillomavirus (hpv) dna testing detects cervical pre-cancerous lesions with a significantly higher sensitivity than the pap smear-based cytology. | 2009 | 20129072 |
| [construction and immunogenicity evaluation of chimerical dna vaccine of human papillomavirus type 11]. | to construct chimerical dna vaccine plasmid of human papillomavirus type 11 (hpv11) l1-e7, and to evaluate its immunogenicity. | 2009 | 20104772 |
| human papilloma virus and cervical preinvasive disease. | cervical cancer lesions represent a major threat to the health of the women worldwide. human papillomavirus (hpv) is responsible for 99.7% of cervical cancer cases, the infectious etiology giving the possibility of preventing cervical cancer by vaccination. the most aggressive hpv types are 16 and 18, which cause about 70% of cases of invasive cancer. the vaccination is recommended to the girls aged 11-12. the diagnosis and the treatment of cervical preinvasive disease allow the doctor to preven ... | 2009 | 20108750 |
| [expression, purification and immunogenicity of human papillomavirus type 11 virus-like particles from escherichia coli]. | to produce human papillomavirus type 11 virus-like particles (hpv11 vlps) from escherichia coli and to investigate its immunogenicity and type cross neutralization nature. | 2009 | 20112683 |
| antibody detection against hpv16 e7 & gp96 fragments as biomarkers in cervical cancer patients. | cervical cancer is the second most frequent cancer among females worldwide, especially human papilloma viruses (hpv) types 16 and 18. in viral systems the identification of serological markers would facilitate the diagnosis of hpv infections and virus-related disease. the aim of the present investigation was to determine and search for serologic markers in cervical cancer patients associated with hpv. | 2009 | 20090101 |
| [the statement of polish gynecological society experts about human papillomavirus (hpv) vaccine use to prevent cervical cancer (state of the art from the 19th of september 2009)]. | 2009 | 20088404 | |
| immunomodulatory activity of a plant extract containing human papillomavirus 16-e7 protein in human monocyte-derived dendritic cells. | this study reports the immunomodulatory activity on human monocyte derived dendritic cells (mddcs) of a vaccine preparation shown to be effective against an hpv16-related tumour in an animal model. the vaccine is composed of extract from nicotiana benthamiana leaves containing hpv16 e7 protein expressed by a potato virus x-derived vector (nbpvx-e7). the effect of the extract was evaluated on mddc differentiation and maturation by monitoring the phenotypic expression of specific markers. the resu ... | 2009 | 20074460 |
| [summary of the practice guideline 'prevention and early diagnosis of cervical cancer' of the dutch college of general practitioners]. | a persistent infection with human papillomavirus (hpv) underlies all cases of cervical cancer. hpv testing is repeated 6 months after initial pap smears 2 or 3a1. as vaccination against hpv is now included in the national immunisation programme of the netherlands, yearly cervical cancer morbidity and mortality rates are expected to be cut by half. after vaccination against hpv, women still need to participate in the cervical cancer screening programme. breastfeeding is no longer a contraindicati ... | 2009 | 20051149 |
| hpv prevalence in colombian women with cervical cancer: implications for vaccination in a developing country. | human papillomavirus (hpv) vaccines have been considered potentially cost-effective for the reduction of cervical cancer burden in developing countries; their effectiveness in a public health setting continues to be researched. we conducted an hpv prevalence survey among colombian women with invasive cancer. paraffin-embedded biopsies were obtained from one high-risk and one low-middle-risk regions. gp5+/gp6+ l1 primers, rlb assays, and e7 type specific pcr were used for hpv-dna detection. 217 c ... | 2009 | 20052389 |
| major clinical research advances in gynecologic cancer 2009. | in this review, we summarized nine major clinical advances in gynecology which occurred in 2009. for cervical cancer, the role of human papillomavirus (hpv) test as a screening test, the efficacy of hpv vaccine for middle-aged women, randomized controlled trial (rct) regarding concurrent chemoradiation using gemcitabine plus cisplatin, and the efficacy of pazopanib for metastatic or recurrent disease were chosen. for endometrial cancer, the necessity of systematic pelvic lymphadenectomy in early ... | 2009 | 20041096 |
| human papillomavirus types 16 and 18 mrna levels and not dna levels may be associated with advancing stages of cervical cancer. | human papillomavirus (hpv) contributes to the development of cervical cancer. we hypothesize that hpv dna and messenger rna (mrna) levels may be associated with increasing stages of cervical cancer. | 2009 | 20009900 |
| the mrna decay factor tristetraprolin (ttp) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting e6-ap ubiquitin ligase. | the rna-binding protein tristetraprolin (ttp) regulates expression of many cancer-associated and proinflammatory factors through binding au-rich elements (are) in the 3'-untranslated region (3'utr) and facilitating rapid mrna decay. here we report on the ability of ttp to act in an anti-proliferative capacity in hpv18-positive hela cells by inducing senescence. hela cells maintain a dormant p53 pathway and elevated telomerase activity resulting from hpv-mediated transformation, whereas ttp expre ... | 2009 | 20157568 |
| sexually transmitted diseases and anorectum. | sexually transmitted diseases (std) are a major public health problem because their incidence is increasing worldwide despite prevention campaigns and because they raise the risk of hiv infection. anorectal localisations of std are common among men who have sex with men (msm) but can also be seen among heterosexuals (men or women). transmission of such infections is due to anal sex or to other sexual behaviours like "fisting". although some pathogens (like human papillomavirus-hpv) are common in ... | 2009 | 20163035 |
| requiring human papillomavirus vaccine for immigrant women. | the centers for disease control and prevention advisory committee on immunization practices recommends human papillomavirus (hpv) vaccination of 11- to 12-year-old girls, with catch-up vaccination for girls and women aged 13 to 26 years. although compulsory hpv vaccination is not currently mandated for any u.s. population, immigrant women aged 11-26 years are now required to receive the first injection of the vaccine (the full series consists of three doses) as a result of the 1996 illegal immig ... | 2009 | 20168117 |
| detection of high risk human papillomavirus cervical infections by the hybrid capture in asunción, paraguay. | cervical cancer is the most frequent malignant tumour of women in latin america being human papillomavirus (hpv) the main cause. the aim of this study was to increase the knowledge about the cervical infections with oncogenic hpv types (hr-hpv) in asuncion, paraguay. two hundred and seventy-two cervical samples were analyzed using hybrid capture ii assay (hca ii) for hr-hpv. the frequency of hr-hpv in the study group was 44%. hr-hpv was detected in 25% of the women negative for squamous intraepi ... | 2009 | 20191197 |
| [a 1:2 matched case-control study on the interaction of hpv16e6 and hla-dr9 allele to esophageal cancer in kazakh ethnicity, xinjiang]. | to evaluate the role and the association between hpv16e6 infection and hla-dr9 immune-associated gene to esophageal cancer (ec) in kazakh of xinjiang, china. | 2009 | 20193235 |
| [preparation of human papillomavirus 16 e7 peptide vaccine and its effectiveness in vitro and in vivo.]. | to prepare the human papillomavirus (hpv) 16 peptide vaccine and explore the effect in vitro and in vivo. | 2009 | 20193416 |
| chlamydia trachomatis detection in cervical preservcyt specimens from an irish urban female population. | the aim of this study was to determine the prevalence of cervical chlamydia trachomatis infection by polymerase chain reaction (pcr) in urban women undergoing routine cervical cytological screening and to investigate the relationship with age, cytology, smoking status and concurrent human papillomavirus (hpv) infection. | 2009 | 18093220 |
| prediction of recurrent disease by cytology and hpv testing after treatment of cervical intraepithelial neoplasia. | to assess the role of human papillomavirus (hpv) testing and cytology as predictors of residual/recurrent disease after treatment of high-grade cervical intraepithelial lesions. | 2009 | 18510550 |
| recent developments in vulvovaginal pathology. | this review discusses recent developments in vulvovaginal pathology. a variety of morphologically bland mesenchymal lesions occur at this site with considerable histological and immunohistochemical overlap. aggressive angiomyxoma exhibits hmga2 immunoreactivity in approximately 50% of cases, and this nuclear transcription factor is emerging as a useful and relatively specific marker for aggressive angiomyxoma, although occasional vulvovaginal smooth muscle neoplasms are positive. hmga2 is useful ... | 2009 | 18637148 |
| factors associated with increased prevalence of human papillomavirus infection in a cohort of hiv-infected brazilian women. | human papillomavirus (hpv) infection is a major risk factor for cervical disease. using baseline data from the hiv-infected cohort of evandro chagas clinical research institute at fiocruz, rio de janeiro, brazil, factors associated with an increased prevalence of hpv were assessed. | 2009 | 18632296 |
| surgery and topic cidofovir for nasal squamous papillomatosis in hiv+ patient. | intranasal schneiderian exophytic squamous papillomatosis is rare and often secondary to human papilloma virus infection. treatment usually consists of repeated surgical or endoscopic excisions due to recurrences. the use of intravenous or intralesional or topically applied cidofovir, a cytidine nucleotide analogue suppressing viral replication, alone or as adjuvant therapy has been proposed and described in the literature for the treatment of other human papillomavirus (hpv)-related lesions. we ... | 2009 | 18648834 |
| association between human papillomavirus in men and their sexual partners and uterine cervical intraepithelial neoplasia. | to determine whether the presence of human papillomavirus (hpv) in men is a risk factor in the development of intraepithelial cervical neoplasia in their sexual partners and to corroborate hpv frequency and type. | 2009 | 18649002 |
| expression of p14arf, p16ink4a and p53 in relation to hpv in (pre-)malignant squamous skin tumours. | studies in cervical dysplasia have reported overexpression of the tumour suppressors p14 and p16 - and absence of p53 - in high-risk human papilloma virus (hpv)- associated lesions. in skin carcinogenesis, the relation between these tumour suppressors and hpv remain unclear. we evaluated the expression of the tumour suppressors p14, p16 and p53 in pre-malignant and malignant squamous skin tumours, and its relation with risk factors for skin carcinogenesis (hpv, immune status and sun exposure). w ... | 2009 | 18681909 |
| current review on squamous intraepithelial lesions of the larynx. | squamous intraepithelial lesions (sils) of the larynx, clinically usually defined as leukoplakia and chronic laryngitis, have remained the main controversial topic in laryngeal pathology for decades as regards classification, histological diagnosis and treatment. sils are caused by smoking and alcohol abuse. there is also mounting evidence that gastroesophageal reflux is a potential aetiological factor. human papillomavirus infection seems to play little if any role in laryngeal carcinogenesis. ... | 2009 | 18752537 |
| variant haplotypes at xrcc1 and risk of oral leukoplakia in hpv non-infected samples. | one of the mechanisms in human papillomavirus (hpv)-related carcinogenesis is inhibition of dna repair by hpv oncoprotein. in this study, we investigated whether polymorphisms at xrcc1, one of the dna repair loci, could modulate the risk of tobacco-related leukoplakia and cancer in hpv-infected individuals. | 2009 | 18764855 |
| intraepithelial and invasive squamous neoplasms of the conjunctiva in ibadan, nigeria: a clinicopathological study of 46 cases. | to retrospectively evaluate the clinicopathological features, treatment modalities and factors affecting prognosis in patients with both conjunctival intraepithelial and invasive squamous neoplasms. | 2009 | 18784902 |
| topical treatment for human papillomavirus-associated genital warts in humans with the novel tellurium immunomodulator as101: assessment of its safety and efficacy. | various methods are currently used for the treatment of anogenital warts. however, a complete cure is unlikely, and the rate of recurrence is high. | 2009 | 18808418 |
| cns demyelination and quadrivalent hpv vaccination. | vaccination is generally considered safe in patients with multiple sclerosis (ms). we report five patients who presented with multifocal or atypical demyelinating syndromes within 21 days of immunization with the quadrivalent human papilloma virus (hpv) vaccine, gardasil. although the target population for vaccination, young females, has an inherently high risk for ms, the temporal association with demyelinating events in these cases may be explained by the potent immuno-stimulatory properties o ... | 2009 | 18805844 |
| [testing of a new probe 16/18/45 hybrid capture (digene) in women with high risk hpv infection]. | hpv hr detection test are needed when ascus is diagnosed on pap test. the risk of progression to cervical cancer is dependant on the hpv genotype and three types (hpv 16, 18 and 45) are found in 77.4% of the cervical cancer. here we have tested a new probe 16/18/45 (digene) that is able to detect specifically these three types. | 2009 | 18824308 |
| single large inguinal lymph node metastasis in human papillomavirus-induced early invasive vulvar cancer of the anterior fourchette in two young women. | the incidence of human papillomavirus (hpv)-induced vulvar cancer in young women is increasing and often presents as microinvasive or early invasive tumors in a grade 3 vulvar intraepithelial neoplasia. so far, the risk of lymph node metastases in early invasive vulvar carcinoma (depth of invasion 1.1-2.0 mm) is reported to be less than 8%. we present 2 cases of young women with early invasive vulvar cancers (depth of invasion 1.5 and 2.0 mm) induced by hpv 16 and 42. in both cases, the cancers ... | 2009 | 18832852 |
| infection and cervical neoplasia: facts and fiction. | whilst there is strong evidence that human papillomavirus (hpv) is the principal aetiological agent in cervical neoplasia, some other sexually transmitted agents may either contribute or protect against cervical carcinogenesis, such as the herpes virus family (hsv), cytomegalovirus (cmv), epstein-barr virus (ebv), human immunodeficiency virus (hiv) or chlamydia trachomatis (ct). epidemiological studies suggest that hsv may have a role in cervical neoplasia, but there is no clear supportive exper ... | 2009 | 18830380 |
| prevalence of human papillomavirus type 16 and its variants in abnormal squamous cervical cells in northeast thailand. | to investigate the prevalence of hpv, hpv16, and hpv16 variants in scraped cervical cells cytologically diagnosed as normal cervical cell and in formalin-fixed, paraffin-embedded tissues of cervical intraepithelial neoplasia ii-iii and squamous cervical carcinoma in northeast thailand. | 2009 | 18838282 |
| hpv-16 e6 l83v variant in squamous cell carcinomas of the upper aerodigestive tract. | the aim of this prospective case series study was to determine the prevalence of hpv-dna, analyze the e6 mrna expression, identify intra-type variation in the e6 oncogene in upper aerodigestive tract (uadt) squamous cell carcinoma (scc), and correlate the presence of hpv-dna with several clinical parameters and outcome. | 2009 | 18841393 |
| human papillomavirus vaccination: what is the best choice? a comparison of 16 strategies by means of a decisional model. | some european countries decided to include human papillomavirus (hpv) vaccines in national immunization schedules. in order to help decision makers choose the best vaccination policy for females, a decisional model has been developed. the study was performed from the national health service perspective. several hypotheses of multi-cohort vaccination policies were compared. 'potentially avoidable infections' were chosen as the outcome. the model envisioned a short-term scenario (2008-2011). the b ... | 2009 | 18925989 |
| successful surgical management of giant condyloma acuminatum (buschke-löwenstein tumor) in the genitoanal region: a case report and evaluation of current therapies. | giant condyloma acuminatum (gca; buschke-lowenstein tumor) is a human-papillomavirus-induced cauliflower-like tumor of the genitoanal region. it is characterized by its size, capability of local infiltration and high recurrence rate. we report on a 50-year-old patient presenting with a maximum finding of gca with deep infiltration into the adductor and perineal musculature, the scrotum, the penis and the para-rectum. after performing a temporary loop colostomy, the tumor was removed by wide radi ... | 2009 | 18936533 |
| optical detection and grading of lung neoplasia by raman microspectroscopy. | the aim of this study was to investigate whether raman spectroscopy could be used to identify and potentially grade lung neoplasia in cell samples. normal human bronchial epithelial cells (hbepcs) were analyzed by raman spectroscopy and compared with (i) hbepcs expressing human papillomavirus (hpv) type 16 e7 or cdk4; (ii) the immortalized bronchial epithelial cell line bep2d and (iii) its asbestos-transformed derivative asbtb2a. overall, raman spectroscopy, in combination with a linear discrimi ... | 2009 | 18942712 |
| control of the papillomavirus early-to-late switch by differentially expressed srp20. | the viral early-to-late switch of papillomavirus infection is tightly linked to keratinocyte differentiation and is mediated in part by alternative mrna splicing. here, we report that srp20, a cellular splicing factor, controls the early-to-late switch via interactions with a/c-rich rna elements. an a/c-rich se4 element regulates the selection of a bovine papillomavirus type 1 (bpv-1) late-specific splice site, and binding of srp20 to se4 suppresses this selection. expression of late bpv-1 l1 or ... | 2009 | 18945760 |
| human papillomavirus type 16 e2 protein transcriptionally activates the promoter of a key cellular splicing factor, sf2/asf. | human papillomavirus (hpv) gene expression is regulated in concert with the epithelial differentiation program. in particular, expression of the virus capsid proteins l1 and l2 is tightly restricted to differentiated epithelial cells. for hpv16, the capsid proteins are encoded by 13 structurally different mrnas that are produced by extensive alternative splicing. previously, we demonstrated that upon epithelial differentiation, hpv16 infection upregulates hnrnp a1 and sf2/asf, both key factors i ... | 2009 | 18945764 |
| preparing for hpv vaccination in south africa: key challenges and opinions. | this article reports on qualitative research investigating key challenges and barriers towards human papillomavirus (hpv) vaccine introduction in the western cape province, south africa. a total of 50 in-depth interviews and 6 focus groups were conducted at policy, health service and community levels of enquiry. respondents expressed overall support for the hpv vaccine, underscored by difficulties associated with the current cervical screening programmes and the burgeoning hiv/aids epidemic in s ... | 2009 | 18977271 |
| the rna stability regulator hur regulates l1 protein expression in vivo in differentiating cervical epithelial cells. | human papillomavirus (hpv) l1 and l2 capsid protein expression is restricted to the granular layer of infected, stratified epithelia and is regulated at least partly at post-transcriptional levels. for hpv16, a 79 nt late regulatory element (lre) is involved in this control. using w12 cells as a model for hpv16-infected differentiating cervical epithelial cells we show that hur, a key cellular protein that controls mrna stability, binds the lre most efficiently in nuclear and cytoplasmic extract ... | 2009 | 18986664 |
| high-risk human papillomavirus dna load in a population-based cervical screening cohort in relation to the detection of high-grade cervical intraepithelial neoplasia and cervical cancer. | in a population-based cervical screening cohort, we determined the value of type-specific viral load assessment for the detection of high-grade cervical intraepithelial neoplasia and cervical cancer (>or=cin2). viral load was determined by type-specific real-time pcr in women with single hpv16,-18,-31 and -33 infections, as determined by gp5+/6+-pcr. study endpoints were the detection of cumulative >or=cin2 or>or=cin3 within 18 months of follow-up. high viral loads of hpv16,-31, and -33 were pre ... | 2009 | 19003961 |
| recurrent respiratory papillomatosis: update 2008. | recurrent respiratory papillomatosis (rrp) is the most common benign neoplasm of the larynx in children. over the past several years some exciting new therapeutic options as well as some relevant research into the disease process has emerged that may offer new insight and methods in managing this frustrating disease. | 2008 | 19005325 |
| human papillomavirus in hnscc: a european epidemiologic perspective. | the aim of this study was to assess incidence and survival of human papillomavirus-related and unrelated head and neck squamous cell carcinoma sites from 15 european population-based cancer registries. this analysis was performed on 29,265 adult (aged approximately 15 years) cancer patients diagnosed in the period from 1988 to 2002. the human papillomavirus-unrelated cancer sites had an age-standardized incidence higher than the human papillomavirus-related cancer cases (3.8 versus 2.5/100,000 y ... | 2008 | 19010264 |
| surgery followed by persistence of high-grade squamous intraepithelial lesions is associated with the induction of a dysfunctional hpv16-specific t-cell response. | to characterize hpv16 e6- and e7-specific t-cell immunity in patients with high-grade squamous intraepithelial lesions (hsil). | 2008 | 19010835 |
| aetiology of cancer in asia. | cancer has become the leading cause of death in many asian countries. there is an increasing trend in breast, prostate and colon cancers, which are considered as typical of economically developed countries. although breast and prostate cancer rates are still lower than in western countries, they are particularly rapidly increasing. in this paper, we review recently published literature to identify important etiologic factors affecting the cancer risk in asian populations. infectious agents such ... | 2008 | 18990005 |
| cervical cancer control research in vietnamese american communities. | census data show that the u.s. vietnamese population now exceeds 1,250,000. cervical cancer among vietnamese american women has been identified as an important health disparity. available data indicate the cervical cancer disparity may be due to low papanicolaou (pap) testing rates rather than variations in human papillomavirus infection rates and/or types. the cervical cancer incidence rates among vietnamese and non-latina white women in california during 2000 to 2002 were 14.0 and 7.3 per 100, ... | 2008 | 18990732 |
| infectious agents and colorectal cancer: a review of helicobacter pylori, streptococcus bovis, jc virus, and human papillomavirus. | based on the high volume of bacteria and viruses that the intestine is exposed to and the importance of infectious agents in some gastrointestinal and anogenital cancers, it is not surprising the many studies have evaluated the association between colorectal cancer and infectious agents. this review highlights investigations of four agents in relation to colorectal cancer. helicobacter pylori, streptococcus bovis, jc virus, and human papillomavirus have all been evaluated as possible etiologic a ... | 2008 | 18990738 |
| prevalence and age distribution of human papillomavirus infection in a population of inuit women in nunavik, quebec. | our aim was to study the prevalence and age distribution of human papillomavirus (hpv) infection among inuit women in nunavik, northern quebec, a population at high risk of cervical cancer. | 2008 | 18990756 |
| prevalence of high-risk human papillomavirus among older women. | to estimate the prevalence, genotypes, and individual-level correlates of high-risk human papillomavirus (hpv) among women aged 57-85. | 2008 | 18978096 |
| examining the association between socioeconomic status and potential human papillomavirus-associated cancers. | this study examined the association between county-level measures of socioeconomic status (ses) and the incidence rate of human papillomavirus(hpv)-associated cancers, including cervical, vulvar, vaginal, anal, penile, and oral cavity and oropharyngeal cancers. | 2008 | 18980274 |
| human papillomavirus and molecular considerations for cancer risk. | human papillomaviruses (hpvs) are a major cause of cancer globally, including cervical cancer. the hpv 'early' proteins, e6 and e7, are the chief oncoproteins involved in cancer progression. these oncoproteins are more highly expressed in high-grade dysplasias and invasive cancer coincident with reduced viral dna replication and reduced production of infective progeny virions. the e6 and e7 oncoproteins interact with several cellular proteins-classically tp53 and rb1, respectively-leading to the ... | 2008 | 18980282 |
| predicting the effect of successful human papillomavirus vaccination on existing cervical cancer prevention programs in the united states. | the development of a prophylactic human papillomavirus (hpv) vaccine that potentially may eliminate a majority of cervical cancers is a landmark in cancer prevention. cervical screening, however, will continue to play an important role for the foreseeable future. maintaining screening at the same intensity and simply adding on the expense of vaccination would result in redundancy of prevention efforts at enormously increased costs without necessarily further reducing cervical cancer mortality. e ... | 2008 | 18980285 |