Publications

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[monthly report on the campaign of eradication of aedes aegypti in american countries, september, 1952]. 195313041772
the growth stimulating effect of apf, terramycin hydrochloride, vitamin b12 and an undetermined factor x upon aedes aegypti (l) diptera, culicidae. 195313007931
control of malaria in mauritius; eradication of anopheles funestus and aedes aegypti. 195313077717
studies on the intake of microfilariae by their insect vectors, their survival, and their effect on the survival of their vectors. i. dirofilaria immitis and aëdes aegypti. 195313080982
studies on plasmodium gallinaceum. iv. a comparison of the susceptibility of aedes aegypti, anopheles quadrimaculatus and anopheles freeborni. 195214933391
the mechanism of the transmission of myxomatosis in the european rabbit (oryctolagus cuniculus) by the mosquito aedes aegypti. 195214934625
[eradication of aedes aegypti and control of yellow fever; four year continental program]. 195114886443
[results of ddt application in french guiana; destruction of the aedes aegypti and spectabular reduction of malaria]. 195124541063
[innocuousness of the addition of 1 ppm of ddt to drinking water for the eradication of aedes aegypti]. 195114821037
estimation of traces of ddt using aedes aegypti larvae as a biological indicator. 195114817816
some nutritional requirements of adult mosquitoes (aedes aegypti) for oviposition. 195114851026
studies on plasmodium gallinaceum. i. characteristics of the infection in the mosquito, aedes aegypti. 195114846794
[attempt at control of aedes aegypti by application of ddt in water tanks]. 195014783641
[control of aedes aegypti in chile]. 195015411454
arrest of development of plasmodium gallinaceum in mosquitoes (aedes aegypti) by radiation effect of p32 1,2. 195015424666
a method of infecting aedes aegypti with plasmodium gallinaceum from chick embryos. 195014795205
aedes aegypti and other mosquito control measures in port sudan. 194915408260
rearing of anopheles quadrimaculatus say and aedes aegypti (l.) in the laboratory. 194915406584
bioassay systems for the pyrethrins; water-base sprays against aëdes aegypti l. and other flying insects. 194918151949
experiments in crossing aedes (stegomyia) aegypti linnaeus and aedes (stegomyia) albopictus skuse. 194917800955
relative susceptibility of aëdes aegypti, aëdes albopictus, aëdes canadensis and anopheles quadrimaculatus to plasmodium gallinaceum. 194918137143
toxicity of limewash containing ddt or gammexane to mosquitos, aëdes aegypti, l. 194818865550
extermination of aëdes aegypti in khartoum. 194818900760
the nutrition of the larva of aëdes aegypti linnaeus; protein and amino-acid requirements. 194818122654
the nutrition of the larva of aëdes aegypti linnaeus; lipid requirements. 194818105885
the nutrition of the larva of aëdes aegypti linnaeus. 4. protein and amino-acid requirements. 194816748417
the nutrition of the larva of aëdes aegypti linnaeus. 3. lipid requirements. 194816748416
stimuli involved in the attraction of aedes aegypti, l., to man. 194818104364
the effect of artificial blood meals containing the hydroxynaphthoquinone m2279 on the developmental cycle pf plasmodium gallinaceum in aedes aegypti. 194818864109
the effect of one plant extract and of certain drugs on the development of plasmodium gallinaceum in aedes aegypti. 194818867818
studies on cyclic passage of yellow fever virus in south american mammals and mosquitoes; marsupials (metachirus nudicaudatus and marmosa) in combination with aedes aegypti as vector. 194818898700
observations on the effect of microclimate on biting by aëdes aegypti (l.) (dipt., culicid.). 194718920748
aedes aegypti control in the absence of a piped potable water supply. 194718897110
further observations on the nutritional requirements of the larva of aedes aegypti l. 194720269871
ddt and aedes aegypti control in british guiana. 194720264247
the inhibition of growth of larvae of aedes aegypti by certain anti-malarial drugs. 194720265407
mortality of aedes aegypti feeding on rabbits receiving oral gammexane. 194720344387
practical laboratory methods for quantity rearing and handling of aedes aegypti mosquitoes to be infected with plasmodium gallinaceum. 194720266394
physiological factors which influence the infection of aedes aegypti with plasmodium gallinaceum. 194720279328
failure of aedes aegypti and culex pipiens to transmit plasmodium vaughani. 194720294091
winter survival of aedes aegypti in houston, texas. 194620995756
chlorine as a possible ovicide for aedes aegypti eggs. 194621027331
experiments upon the feeding of aedes aegypti through animal membranes with a view to applying this method to the chemotherapy of malaria. 194621014255
studies on cyclic passage of yellow fever virus in south american mammals and mosquitoes; marmosets (callithrix penicillata and leontocebus chrysomelas) in combination with aedes aegypti. 194620996629
occurrence of aedes aegypti in british guiana. 194520998212
aedes aegypti linnaeus, the yellow fever mosquito, in central missouri. 194217752151
measures instituted for the control of aëdes aegypti. 194018015233
the absence from the urine of pernicious anemia patients of a mosquito growth factor present in normal urine.extracts prepared from the urine of normal persons or patients with aplastic anemia or leukemia contain a substance, possibly flavine or a flavine compound, which under suitable conditions of test enhances the growth of larvae of the mosquito, aëdes aegypti. this substance is lacking, or is present in much smaller amount, in extracts from the urine of pernicious anemia patients showing symptoms of the disease. extracts from the urine of the same patients after adequate treatment contain as much ...193819870733
control of stegomyia fasciata (ædes ægypti) mosquitoes in indian country craft by a mosquito-proof metal cap (bennett pattern) for drinking-water receptacles. 193829014217
the multiplication of the virus of yellow fever in aedes aegypti.aëdes aegypti have been shown to be capable of multiplying the asibi strain of yellow fever virus in their bodies. following the ingestion of infected blood, the content of virus falls for several days, reaching a minimum during the 1st week. it then increases rapidly until quantities of virus greater than those previously encountered can be demonstrated. the actual final amount of virus demonstrable, however, is subject to variations of which we know little.193719870651
a practical way of dealing with ædes ægypti (stegomyia fasciata) mosquito breeding in country craft. 193629013069
a practical way of dealing with ædes ægypti (stegomyia fasciata) mosquito breeding in country craft. 193629012997
the transmission of equine encephalomyelitis virus by aedes aegypti.in confirming kelser's work on the transmission of equine encephalomyelitis of the western type by aëdes aegypti it has been learned that the mosquitoes must be fed virus of high titer if positive results are to be secured. a period of from 4 to 5 days after feeding either on infected guinea pigs or on brain containing virus must elapse before the disease is transmitted by biting, but after this time transmission regularly results for a period of about 2 months. by inoculation, virus can be demo ...193519870442
recent laboratory contributions to the control of yellow fever: (section of tropical diseases and parasitology).the most important recent laboratory contributions to the control of yellow fever will be briefly summarized under three headings: (1) methods of diagnosis, (2) transmission, and (3) protection.(1) methods of diagnosis.-the development of improved methods of identification, in particular by immunity tests, has made it possible to diagnose yellow fever with much greater certainty. moreover, since the immunity following an attack of the disease is usually of life-long duration, it is possible to d ...193319989606
possibility of hereditary transmission of yellow fever virus by aedes aegypti (linn.).attempts to obtain passage of yellow fever virus from one generation to the next in a. aegypti were unsuccessful. subcutaneous injections at varying intervals of a saline emulsion of 200 eggs laid by an infective lot of mosquitoes produced no reaction in six normal m. rhesus monkeys. negative results were also obtained in five biting and two injection experiments with progeny of the same infective lot of mosquitoes in which seven normal monkeys were used. the eggs consisted of batches laid after ...192919869656
the filtrability of yellow fever virus as existing in the mosquito.the virus of yellow fever as it exists in aëdes aegypti mosquitoes, both in their so-called infective stage and in the intermediate condition termed the "incubation period", is capable of passing through berkefeld n filters when suspended in normal monkey serum, although earlier investigators have shown that the virus from infective mosquitoes will not do so when suspended in physiological salt solution. the virus of yellow fever as it exists in mosquitoes behaves with regard to filtration throu ...192919869658
studies on yellow fever in south america : iv. transmission experiments with aedes aegypti.1. batches of aëdes (stegomyia) aegypti which had fed on monkeys in the early febrile stage of yellow fever and which has subsequently passed the usually accepted extrinsic incubation period for the virus, failed to transmit the disease to normal monkeys in approximately fifty per cent of the experiments. during the same time over eighty per cent of blood transfers were successful. 2. the monkeys which failed to show fever following mosquito bites later proved resistant to the inoculation of blo ...192919869665
the incubation period of yellow fever in the mosquito.1. the yellow fever virus was found in infectious form in aedes aegypti throughout the entire period of the extrinsic incubation, as demonstrated by the injection of the bodies of mosquitoes into normal rhesus monkeys at daily intervals after the insects had fed on an infected animal. 2. the virus was transmitted through the bite of the mosquitoes, in one experiment on and after the 9th day, and in two experiments on the 12th day after the initial infecting feed. 3. the pathologic changes produc ...192819869467
the yellow-fever mosquito. 190617737726
concerning the geographic distribution of the yellow fever mosquito. 190319601151
biological and molecular properties of dengue 2 strains isolated during the dhf/dss cuban epidemic, 1981.to study some biological and molecular properties of nine denv-2 strains isolated during the 1981 cuban epidemic, temperature sensitivity, viral plaque size, the kinetic of virus replication in newborn mice inoculated by intracerebral route, the influence of ph medium on virus-cell attachment phase and the restriction enzyme pattern were studied. strains were classified in two patterns according to temperature sensitivity, plaque size, and virus replication in mouse brain and cell culture and re ...023675036
using fluorescently labelled m13-tailed primers to isolate 45 novel microsatellite loci from the arboviral vector culex tarsalis.culex tarsalis coquillett (diptera: culicidae) is a highly efficient arbovirus vector. spatial and temporal heterogeneity have been observed in cx tarsalis for phenotypic traits including autogeny, virus susceptibility and host preference. genetic differences between populations may in part explain these observations. using the m13-tailed primer method, we identified 45 novel polymorphic microsatellite markers from microsatellite-enriched cx tarsalis genomic libraries. the m13-tailed primer meth ...017550440
dengue fever seroprevalence and risk factors, texas-mexico border, 2004.reported autochthonous dengue fever transmission in the united states has been limited to 5 south texas border counties since 1980. we conducted a cross-sectional serosurvey in brownsville, texas, and matamoros, tamaulipas, mexico (n = 600), in 2004 to assess dengue seroprevalence. recent dengue infection was detected in 2% (95% confidence interval [ci] 0.5%-3.5%) and 7.3% (95% ci 4.3%-10.3%) of residents in brownsville and matamoros, respectively. past infection was detected in 40% (95% ci 34%- ...018257990
defeating dengue: a difficult task ahead. 018038050
primary dengue haemorrhagic fever in patients from northeast of brazil is associated with high levels of interferon-β during acute phase.dengue is an acute febrile disease caused by the mosquito-borne dengue virus (denv) that according to clinical manifestations can be classified as asymptomatic, mild or severe dengue. severe dengue cases have been associated with an unbalanced immune response characterised by an over secretion of inflammatory cytokines. in the present study we measured type i interferon (ifn-i) transcript and circulating levels in primary and secondary denv infected patients. we observed that dengue fever (df) a ...027223651
what does not kill them makes them stronger: larval environment and infectious dose alter mosquito potential to transmit filarial worms.for organisms with complex life cycles, larval environments can modify adult phenotypes. for mosquitoes and other vectors, when physiological impacts of stressors acting on larvae carry over into the adult stage they may interact with infectious dose of a vector-borne pathogen, producing a range of phenotypes for vector potential. investigation of impacts of a common source of stress, larval crowding and intraspecific competition, on adult vector interactions with pathogens may increase our unde ...024827444
dengue: moving from current standard of care to state-of-the-art treatment.treatment of dengue remains supportive in the absence of targeted antiviral therapy or approved vaccines. responsive fluid management is key to preventing progression to shock or other severe manifestations. the dynamic natural history of dengue infection and its influence on hemodynamic homeostasis needs to be carefully considered in the planning of individualized therapy. though largely self-limiting, the sheer burden of dengue disease on the global population will result in atypical manifesta ...025999799
genomic mapping of suppressor of hairy-wing binding sites in drosophila.insulator elements are proposed to play a key role in the organization of the regulatory architecture of the genome. in drosophila, one of the best studied is the gypsy retrotransposon insulator, which is bound by the suppressor of hairy-wing (su [hw]) transcriptional regulator. immunolocalization studies suggest that there are several hundred su(hw) sites in the genome, but few of these endogenous su(hw) binding sites have been identified.017705839
drosophila by the dozen. 017634150
within-host viral dynamics of dengue serotype 1 infection.dengue, the most common mosquito-borne viral infection of humans, is endemic across much of the world, including much of tropical asia and is increasing in its geographical range. here, we present a mathematical model of dengue virus dynamics within infected individuals, detailing the interaction between virus and a simple immune response. we fit this model to measurements of plasma viral titre from cases of primary and secondary denv 1 infection in vietnam. we show that variation in model param ...024829280
[environmental pollution, climate variability and climate change: a review of health impacts on the peruvian population].this article is a review of the pollution of water, air and the effect of climate change on the health of the peruvian population. a major air pollutant is particulate matter less than 2.5 μ (pm 2.5). in lima, 2,300 premature deaths annually are attributable to this pollutant. another problem is household air pollution by using stoves burning biomass fuels, where excessive indoor exposure to pm 2.5 inside the household is responsible for approximately 3,000 annual premature deaths among adults, ...025418656
temporal correlations between mosquito-based dengue virus surveillance measures or indoor mosquito abundance and dengue case numbers in mérida city, méxico.surveillance of dengue virus (denv) in aedes (stegomyia) aegypti (l.) females is of potential interest because human denv infections are commonly asymptomatic, which decreases the effectiveness of dengue case surveillance to provide early warning of building outbreaks. our primary aim was to examine if mosquito-based virological measures--monthly percentages of examined ae. aegypti females infected with denv or examined homes from which at least one denv-infected ae. aegypti female was collected ...025118425
dengue human infection models supporting drug development.dengue is a arboviral infection that represents a major global health burden. there is an unmet need for effective dengue therapeutics to reduce symptoms, duration of illness and incidence of severe complications. here, we consider the merits of a dengue human infection model (dhim) for drug development. a dhim could allow experimentally controlled studies of candidate therapeutics in preselected susceptible volunteers, potentially using smaller sample sizes than trials that recruited patients w ...024872399
the role of the mosquito in a dengue human infection model.recent efforts to combat the growing global threat of dengue disease, including deployment of phase iib vaccine trials, has continued to be hindered by uncertainty surrounding equitable immune responses of serotypes, relative viral fitness of vaccine vs naturally occurring strains, and the importance of altered immune environments due to natural delivery routes. human infection models can significantly improve our understanding of the importance of certain phenotypic characteristics of viral str ...024872400
chemical composition and biological activity of star anise illicium verum extracts against maize weevil, sitophilus zeamais adults.this study aims to develop eco-friendly botanical pesticides. dried fruits of star anise (illicium verum hook.f. (austrobaileyales: schisandraceae)) were extracted with methyl alcohol (ma), ethyl acetate (ea), and petroleum ether (pe) at 25°c. the constituents were determined by gas chromatography-mass spectrometry, and the repellency and contact toxicity of the extracts against sitophilus zeamais motschulsky (coleoptera: curculionidae) adults were tested. forty-four compounds, whose concentrati ...025368036
modified technique of wolbachia removal from malaysian aedes albopictus.to develop an artificial and modified wolbachia removal technique using tetracycline from naturally wolbachia infected aedes albopictus (ae. albopictus) so as to be able to produce generations of wolbachia free offsprings.025183276
oviposition habitat selection by container-dwelling mosquitoes: responses to cues of larval and detritus abundances in the field.insects' oviposition responses to resource and larval densities can be important factors determining distributions and competitive interactions of larvae. aedes albopictus (skuse) and aedes aegypti (l.) (diptera: culicidae) show aggregated distributions of larvae in the field, larval interactions that are affected by detritus resources, and oviposition responses to resource and density cues in the laboratory. we conducted field experiments testing whether these species choose oviposition sites i ...024678139
spontaneous splenic rupture: a rare presentation of dengue fever.spontaneous rupture of the spleen with hemoperitoneum is a very rare, but serious manifestation of dengue fever (df). we report a case of a young female who was presented with atraumatic abdominal pain, hypovolemic shock, anemia, ascites and hepatosplenomegaly with a recent history of a febrile illness. subsequent investigations proved the presence of hemoperitoneum with spontaneous splenic rupture with seropositivity for df. early diagnosis and conservative management in this case resulted in a ...024678156
clove (syzygium aromaticum): a precious spice.clove (syzygium aromaticum) is one of the most valuable spices that has been used for centuries as food preservative and for many medicinal purposes. clove is native of indonesia but nowadays is cultured in several parts of the world including brazil in the state of bahia. this plant represents one of the richest source of phenolic compounds such as eugenol, eugenol acetate and gallic acid and posses great potential for pharmaceutical, cosmetic, food and agricultural applications. this review in ...025182278
essential oils from two eucalyptus from tunisia and their insecticidal action on orgyia trigotephras (lepidotera, lymantriidae).essential oils extracted from aromatic and medicinal plants have many biological properties and are therefore an alternative to the use of synthetic products. the chemical composition of essential oils from two medicinal plants (eucalyptus globulus and e. lehmannii) was determined and, their insecticidal effects on the third and fourth larval stages of orgyia trigotephras were assessed.025204015
origin of the dengue virus outbreak in martin county, florida, usa 2013.after a 75-year absence from florida, substantial local transmission of dengue virus (denv) occurred in key west, monroe county, florida in 2009 and continued in 2010. the outbreak culminated in 85 reported cases. in 2011 and 2012, only isolated cases of local denv transmission were reported in florida, none were reported in key west. in 2013, a new outbreak occurred, but this time in martin county about 275 miles north of key west with 22 reported cases. as the key west and martin county outbre ...025664240
the locust genome provides insight into swarm formation and long-distance flight.locusts are one of the world's most destructive agricultural pests and represent a useful model system in entomology. here we present a draft 6.5 gb genome sequence of locusta migratoria, which is the largest animal genome sequenced so far. our findings indicate that the large genome size of l. migratoria is likely to be because of transposable element proliferation combined with slow rates of loss for these elements. methylome and transcriptome analyses reveal complex regulatory mechanisms invo ...024423660
[the incorporation of activities to control dengue by community health agents].to evaluate the performance of community health agents when dengue control activities were added to their tasks.024789644
quantification of ortholog losses in insects and vertebrates.the increasing number of sequenced insect and vertebrate genomes of variable divergence enables refined comparative analyses to quantify the major modes of animal genome evolution and allows tracing of gene genealogy (orthology) and pinpointing of gene extinctions (losses), which can reveal lineage-specific traits.018021399
inferring genome-scale rearrangement phylogeny and ancestral gene order: a drosophila case study.a simple, fast, and biologically inspired computational approach for inferring genome-scale rearrangement phylogeny and ancestral gene order has been developed. this has been applied to eight drosophila genomes. existing techniques are either limited to a few hundred markers or a small number of taxa. this analysis uses over 14,000 genomic loci and employs discrete elements consisting of pairs of homologous genetic elements. the results provide insight into evolutionary chromosomal dynamics and ...017996033
the significance of ratios of detritus types and micro-organism productivity to competitive interactions between aquatic insect detritivores.investigations of competitive interactions emphasize non-detrital resources, even though detritus is a major component of most food webs. studies of competing species focus usually on single resource types, although consumers in nature are likely to encounter mixtures of resource types that may affect whether competition results in exclusion or coexistence. the invasive mosquito aedes albopictus is capable of excluding the native mosquito ochlerotatus triseriatus in competition for single detrit ...017922707
surprising complexity of the ancestral apoptosis network.apoptosis, one of the main types of programmed cell death, is regulated and performed by a complex protein network. studies in model organisms, mostly in the nematode caenorhabditis elegans, identified a relatively simple apoptotic network consisting of only a few proteins. however, analysis of several recently sequenced invertebrate genomes, ranging from the cnidarian sea anemone nematostella vectensis, representing one of the morphologically simplest metazoans, to the deuterostomes sea urchin ...017958905
methods for talen evaluation, use, and mutation detection in the mosquito aedes aegypti.the generation and study of transgenic aedes aegypti mosquitoes provides an essential tool for elucidating the complex molecular biology of this important vector. within the field, genetic manipulation has surpassed the proof of principle stage and is now utilized in both applied and theoretical vector control strategies. the application of new instruments, technologies and techniques allows ever more controlled experiments to be conducted. in this text we describe microinjection of ae. aegypti ...026443221
the fielding h. garrison lecture: "break-bone" fever in philadelphia, 1780: reflections on the history of disease.in the autumn of 1780 an epidemic hit the city of philadelphia. the symptoms of the disease resembled those of present day dengue fever, and subsequent observers argued that the disease was in fact dengue. but was it? the question forces us to confront the challenges of retrospective epidemiology and how we examine the history of a disease. this paper examines the 1780 epidemic from two perspectives. first, it looks at evidence that the disease was dengue and examines what this tells us about th ...027374846
evaluation of mosquito repellent activity of isolated oleic acid, eicosyl ester from thalictrum javanicum.to evaluate the traditional use, the mosquito repellent property of thalictrum javanicum and to confirm the predicted larvicidal activity of the isolated compound, oleic acid, eicosyl ester from its aerial parts by pass software, the present study was carried out using 4th instar stage larvae of the mosquitoes, aedes aegypti (dengue vector) and culex quinquefasciatus (filarial vector). insecticidal susceptibility tests were conducted and the mortality rate was observed after 24 h exposure. the c ...027168688
global distribution and environmental suitability for chikungunya virus, 1952 to 2015.chikungunya fever is an acute febrile illness caused by the chikungunya virus (chikv), which is transmitted to humans by aedes mosquitoes. although chikungunya fever is rarely fatal, patients can experience debilitating symptoms that last from months to years. here we comprehensively assess the global distribution of chikungunya and produce high-resolution maps, using an established modelling framework that combines a comprehensive occurrence database with bespoke environmental correlates, inclu ...027239817
pupal productivity & nutrient reserves of aedes mosquitoes breeding in sewage drains & other habitats of kolkata, india: implications for habitat expansion & vector management.the quality of breeding sites is reflected through the pupal productivity and the life history traits of aedes mosquitoes. using nutrient reserves and pupal productivity of aedes as indicators, the larval habitats including sewage drains were characterized to highlight the habitat expansion and vector management.026905248
spatial distribution & physicochemical characterization of the breeding habitats of aedes aegypti in & around kolkata, west bengal, india.dengue infection is endemic in several areas and the dengue virus is transmitted by aedes mosquitoes. thus, it becomes important to understand the breeding ecology of dengue vector and characterize the physicochemical parameters of its breeding habitat. the objective of this study was to analyze the physicochemical parameters of the breeding habitat of the dengue vector and to find out the nutrient composition of the habitat in and around kolkata, west bengal. in addition, a geographic informati ...026905247
chikungunya outbreak in atmakur village, medak district, telangana state, india. 026905235
assessment of blood collection from the lateral saphenous vein for microfilaria counts in mongolian gerbils (meriones unguiculatus) infected with brugia pahangi.the nih guidelines for survival bleeding of mice and rats note that using the retroorbital plexus has a greater potential for complications than do other methods of blood collection and that this procedure should be performed on anesthetized animals. lateral saphenous vein puncture has a low potential for complications and can be performed without anesthesia. mongolian gerbils (meriones unguiculatus) are the preferred rodent model for filarial parasite research. to monitor microfilaria counts in ...026678366
accuracy of dengue reporting by national surveillance system, brazil. 026812472
the origin and evolution of six miniature inverted-repeat transposable elements in bombyx mori and rhodnius prolixus.miniature inverted-repeat transposable elements (mites) are a specific group of nonautonomous dna transposons, and they are distributed in a wide range of hosts. however, the origin and evolutionary history of mites in eukaryotic genomes remain unclear. in this study, six mites were identified in the silkworm (bombyx mori). five elements are grouped into four known superfamilies of dna transposons, and one represents a novel class of mites. unexpectedly, six similar mites are also present in the ...024115603
the genome of mesobuthus martensii reveals a unique adaptation model of arthropods.representing a basal branch of arachnids, scorpions are known as 'living fossils' that maintain an ancient anatomy and are adapted to have survived extreme climate changes. here we report the genome sequence of mesobuthus martensii, containing 32,016 protein-coding genes, the most among sequenced arthropods. although m. martensii appears to evolve conservatively, it has a greater gene family turnover than the insects that have undergone diverse morphological and physiological changes, suggesting ...024129506
genomic evolution of the pathogenic wolbachia strain, wmelpop.most strains of the widespread endosymbiotic bacterium wolbachia pipientis are benign or behave as reproductive parasites. the pathogenic strain wmelpop is a striking exception, however: it overreplicates in its insect hosts and causes severe life shortening. the mechanism of this pathogenesis is currently unknown. we have sequenced the genomes of three variants of wmelpop and of the closely related nonpathogenic strain wmelcs. we show that the genomes of wmelcs and wmelpop appear to be identica ...024190075
a phylogenetic study of drosophila splicing assembly chaperone rnp-4f associated u4-/u6-snrna secondary structure.the rnp-4f gene in drosophila melanogaster encodes nuclear protein rnp-4f. this encoded protein is represented by homologs in other eukaryotic species, where it has been shown to function as an intron splicing assembly factor. here, rnp-4f is believed to initially bind to a recognition sequence on u6-snrna, serving as a chaperone to facilitate its association with u4-snrna by intermolecular hydrogen bonding. rna conformations are a key factor in spliceosome function, so that elucidation of chang ...025419488
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