Publications

peripheral basis for the auditory deficit in belgian waterslager canaries (serinus canarius).	recently, behavioural thresholds obtained in canaries of the belgian waterslager strain showed that these birds have an inherited auditory deficit. canaries of this strain have absolute auditory thresholds at frequencies above 2.0 khz that are as much as 40 db above the threshold of canaries of other strains. we obtained audiograms from cochlear microphonics and from compound action potentials from the 8th nerve of waterslager and non-waterslager canaries and compare these results to previous be ...	1995	7744706
[listeriosis in the nonpregnant adult during an epidemic outbreak on grand canary].	twenty-two cases of community-acquired epidemic listeriosis were recorded from december 31st, 1991, to may 15th, 1993, at the nuestra señora del pino hospital, las palmas. the incidence during this outbreak was 31 times higher than the corresponding incidence in the last few years. twelve cases occurred in pregnant women and/or neonates and ten in non-pregnant adult individuals. our aim was to study the clinical, biological, radiological, and evolutive issues in non-pregnant adult patients. six ...	1995	7754149
central nervous system toxoplasmosis in roller canaries.	several birds in a flock of 40 roller canaries (serinus canaria) from an outdoor aviary in victoria, australia, developed central nervous system signs that included blindness, nystagmus, ataxia, and head rotation. four died, and four were euthanatized. two euthanatized birds were submitted for microscopic examination of tissues. brain lesions in both birds consisted of scattered foci of nonsuppurative meningoencephalitis with gliosis, mild to moderately extensive lymphocytic/plasmacytic perivasc ...	1995	7794185
glucose-6 phosphate dehydrogenase mutations and haplotypes in various ethnic groups.	mutations that produce glucose-6-phosphate dehydrogenase (g6pd) deficiency have been identified in samples from patients with hemolytic disease in the united states, and in g6pd-deficient samples from greece, the canary islands, the czech and slovak republics, south china, and in samples from the coriell cell repository. eight new mutations are described. particularly unusual were a nonsense mutation ("g6pd georgia"1284a), a deletion of six bases ("g6pd stony brook" 724-729 del) coding for two a ...	1995	7803800
genetic diversity among xanthomonas campestris strains pathogenic for small grains.	a collection of 51 xanthomonas campestris strains from throughout the world was studied to detect and assess genetic diversity among pathogens of small grains. isolates from barley, bread wheat, bromegrass, canary grass, cassava, maize, orchard grass, rice, rough-stalked meadow grass, rye, timothy, and triticale were analyzed by pathogenicity tests on bread wheat cv. alondra and barley cv. corona, indirect immunofluorescence, and restriction fragment length polymorphism (rflp). three probes were ...	1995	16534952
research on better vaccine takes off, as measles deadlines loom. cvi goal: vaccines given earlier in life.	progress is reported on the development of measles vaccines which are not heat sensitive, will not be administered by injection, increase the coverage period, and are unaffected by maternal anti-measles antibodies present in infants aged under 6 months. the world health organization's global program for vaccines and immunization and the children's vaccine initiative are working on a rapid field test for diagnosing measles. measles campaigns have proven successful at achieving high coverage rat ...	1995	12290724
the lizard gallotia galloti as a bioindicator of organophosphorus contamination in the canary islands.	the aim of this study is to propose a bioindicator organism, the lizard gallotia galloti, and a nondestructive biomarker assay, utilising serum butyrylcholinesterase, for the assessment of the toxicological impact of organophosphorus (op) insecticides in the canary islands. laboratory and field studies were performed using the op insecticide trichlorphon. in the laboratory study, experimental groups of gallotia galloti were treated with 5, 50 and 100 mg/kg of trichlorphon, respectively, and afte ...	1995	15091578
optical seeing-mechanism of formation of thin turbulent laminae in the atmosphere.	data from balloon soundings taken at sites in the canary islands, france, and chile are used to show that hydrodynamic instability, perhaps engendered by the propagation of buoyancy (gravity) or other waves, leads to the formation of thin, turbulent laminae, or "seeing layers." these seeing layers occur almost invariably in pairs and exhibit large values for the temperature-structure coefficient c(t)(2) because they form where the gradient of temperature is particularly steep. the refractive-ind ...	1995	21060368
effect of penicillium chrysogenum on lignin transformation.	a strain of penicillium chrysogenum has been isolated from pine forest soils in tenerife (canary islands). this strain was capable of utilizing hydroxylated and nonhydroxylated aromatic compounds, in particular cinnamic acid, as its sole carbon source. in an optimum medium with high levels of nitrogen (25.6 mm) and low levels of glucose (5.5 mm), it was able to decolorize poly b-411 and to transform kraft, organosolv, and synthetic dehydrogenative polymerisate lignins. after 30 days of incubatio ...	1994	16349361
applications of geostatistics in plant nematology.	the application of geostatistics to plant nematology was made by evaluating soil and nematode data acquired from 200 soil samples collected from the a(p) horizon of a reed canary-grass field in northern minnesota. geostatistical concepts relevant to nematology include semi-variogram modelling, kriging, and change of support calculations. soil and nematode data generally followed a spherical semi-variogram model, with little random variability associated with soil data and large inherent variabil ...	1994	19279938
pathogenic staphylococci and staphylococcal infections in canaries.	staphylococcus aureus was isolated from six cases of bacterial infection in canaries, staphylococcus hyicus from three and staphylococcus intermedius from one case. staphylococcus aureus was most often involved in outbreaks of septicaemia, with or without 'megabacterium' proventriculitis. the other coccal species were mainly complicating disease caused by atoxoplasma (lankesterella), chlamydia psittaci and canary pox.	1994	18671080
caprine contagious agalactia caused by mycoplasma agalactiae in the canary islands.		1994	7985334
[the detection of the causative agent of cryptosporidiosis in man and animals in turkmenistan].	the oocystic infestation of cryptosporidia in patients with acute intestinal infections was first registered in turkmenistan. it was 15.8%, highly affecting children of the first two years of life. the monoinfection is characterized by common severe and critical forms (in 60%) with marked symptoms of diarrhea. cases of hemocolitis were detected. a large source of cryptosporidium infection was found among 8 animal species under study (chickens, ducks, pigeons, canary birds, sheep, cattle, pigs, d ...	1994	8015529
distribution of metals in some fishes from santa cruz de tenerife, canary islands.		1994	8142707
[age of menopause onset in canary islands women].	to establish the age at menopause in the canary woman. to study the possible influence of habitat, socioeconomical status and other possible factors on it.	1994	7716428
inner-ear abnormalities and their functional consequences in belgian waterslager canaries (serinus canarius).	recent reports of elevated auditory thresholds in canaries of the belgian waterslager strain have shown that this strain has an inherited auditory deficit in which absolute auditory thresholds at high frequencies (i.e. above 2.0 khz) are as much as 40 db less sensitive than the thresholds of mixed-breed canaries and those of other strains. the measurement of cap audiograms showed that the hearing deficit is already present at the level of the auditory nerve (gleich and dooling, 1992). here we sh ...	1994	7806475
contribution of neurons born during embryonic, juvenile, and adult life to the brain of adult canaries: regional specificity and delayed birth of neurons in the song-control nuclei.	neurogenesis occurs in adult song birds, which suggests that neurons born after hatching may contribute to histogenesis and plasticity of the avian brain. however, little is known about the overall contribution to the mature brain of neurons born in juveniles and adults, and how this process affects different regions of the avian brain. in fact, studies of the histogenesis of the avian forebrain have made the classical assumption that neuronal birth ends before hatching. here we determined the c ...	1994	7814666
immediate-early gene responses in the avian song control system: cloning and expression analysis of the canary c-jun cdna.	previous studies have shown that song presentation results in a rapid rise in mrna levels for the zenk gene (the avian homologue of zif-268, egr-1, ngfi-a, and krox-24) in specific parts of the songbird forbrain. metrazole-induced seizures also cause an increase in zenk mrna, even more widely throughout the telencephalon. surprisingly, however, little or no zenk induction by either stimulus was observed in several forebrain areas involved in auditory processing and song production. to learn whet ...	1994	7898314
value of elisa using a60 antigen in the serodiagnosis of tuberculosis.	this study was set in a general, university hospital in the canary islands, with the objective to evaluate an enzyme-linked immunosorbent assay (elisa) using a60 in the serodiagnosis of tuberculosis. igg antibody to a60 was determined in 205 patients with active disease [149 culture-positive patients with pulmonary tuberculosis (positive sputum smear 94, negative sputum smear 55) and 56 patients with extrapulmonary tuberculosis], 20 patients with inactive disease, 22 patients with lepromatous le ...	1994	7800961
exogenous testosterone differentially affects myelination and neurone soma sizes in the brain of canaries.	we assessed the temporal and functional relationship of myelin maturation and of neuronal development in the telencephalic song motor centres of the canary at different developmental stages. brain differentiation was modulated by exogenous testosterone, its effects on song quality were also monitored. myelin maturation was studied by using computer aided analysis of silver impregnated brain sections, whereas the differentiation of neurones was determined by measuring neuronal soma sizes. at an e ...	1994	7948836
[urinary bilharziasis. comments on 10 cases].	urinary bilharziasis is a parasitic disease caused by schistosome haematobium which is prevalent in several african and middle east countries. the closeness of the canary islands to the african continent and a greater population mobility have allowed us to diagnose and treat ten patients, all of them natural of this region. this paper outlines the case-reports, and reviews this parasitic disease which seriously affects the urinary tract and which must be specifically contemplated both in emigran ...	1994	7976693
the nutrition of the canary (serinus canarius).		1994	7996258
anaphylaxis due to limpet ingestion.	the limpet, phylum mollusca, is one of the most frequent sea mollusks in the canary islands. limpet ige hypersensitivity reactions have been described.	1994	7998665
entrainment properties of the circadian system changing with reproductive state and molt in the canary.	changes in entrainment properties of the circadian pacemaking system with respect to changes in reproductive state and molt were investigated in the male domestic canary (serinus canaria). in two experiments canaries were subjected to three and two similar sequences of light regimens, respectively, during 1 year. locomotor activity, feeding, and vocalization were simultaneously recorded. only birds showing complete postnuptial wing feather molt and related changes in behavior (vocalization) expr ...	1994	8022897
n-cadherin and ng-cam/8d9 are involved serially in the migration of newly generated neurons into the adult songbird brain.	in the adult avian forebrain, neurons continue to be produced in the subependymal zone (sz), from which they migrate upon radial fibers. to identify ligands regulating this process, we studied n-cadherin and ng-cam/8d9 expression in hvc, a neurogenic region of the canary neostriatum. n-cadherin was relatively restricted to the sz and was expressed by dividing, [3h]thymidine-labeled precursor cells. however, cellular n-cadherin was down-regulated prior to neuronal migration from the sz. addition ...	1994	7522481
parasites of south african freshwater fish. vii. nematodes of some scaled fishes from the hartbeespoort dam, transvaal.	the nematode parasites of 16 large-scaled yellowfish, barbus marequensis, six silverfish, barbus mattozi, six small-scaled yellowfish, barbus polylepis, 52 canary kurper, chetia flaviventris, 11 carp, cyprinus carpio, 45 mozambique bream, oreochromis mossambicus and a single-banded bream, tilapia sparrmani, caught in the hartbeespoort dam, transvaal, were collected, identified and counted. contracaecum spp. larvae were recovered from one o. mossambicus, 40 chetia flaviventris, three cyprinus car ...	1994	7596571
radiopaque transverse lines (harris lines) in the prehispanic population of el hierro (canary islands).	harris lines were assessed in 48 right tibiae of prehispanic inhabitants of el hierro (one of the canary islands), belonging to 23 adult females and 25 adult males. no harris lines were detected in sixteen (33%) of the adult individuals (7 females = 30% and 9 males = 36%), these differences are not statistically significant. female tibiae showed a slightly higher mean number of harris lines at the distal end than male ones (2.091 +/- 1.9 in females vs 1.417 +/- in males). ages at which harris li ...	1994	8192433
different pattern of ige binding to chicken egg yolk between patients with inhalant allergy to birds and food-allergic children.	ige binding antigens in budgerigar, canary and parrot serum were analyzed by immunoblotting. with 4 sera from patients with a respiratory allergy to birds, a closely related pattern of ige binding to sds-page separated sera of the 3 birds was found. in all 3 bird sera a major ige binding structure was present with a mw of about 60 kd. the pattern of ige binding to sds-page separated egg yolk in sera from the patients allergic to birds, was different from sera of food-allergic children. whereas i ...	1994	8199464
human enzyme polymorphism in the canary islands. vi. northwest african influence.	the genetic polymorphism of eight red cell enzymes was analyzed in population samples from the northwest african continent and from the south of spain in order to study their genetic relationships with the canarian population. the moroccan, berber and spanish populations, although geographically more distant from the canary islands than the saharan and mauritanian ones, are genetically more closely related to the canarian population. the glucose-6-phosphate dehydrogenase gc allele earlier found ...	1994	8039799
the life span of new neurons in a song control nucleus of the adult canary brain depends on time of year when these cells are born.	the number of high vocal center (hvc) neurons labeled in adult male canaries by systemic injections of [3h]thymidine depended on season and survival time. this was true for hvc neurons projecting to the robust nucleus of the archistriatum and for other hvc neurons that could not be retrogradely filled from the robust nucleus of the archistriatum. birds injected in october and killed 40 days later had twice as many labeled hvc neurons as birds injected in may and killed 40 days later. however, th ...	1994	8058722
allergens causing bird fancier's asthma.	the study investigates to what extent bird feathers contain relevant allergens/antigens involved in bird fancier's asthma. the study group consisted of two budgerigar fanciers, two parrot fanciers and one canary fancier. all subjects complained of asthmatic symptoms, caused by contact with their birds, and they showed a significant bronchial hyperreactivity to acetylcholine. positive ige antibody reactions to bird sera as well as to extracts of feathers were observed in rast. well-defined major ...	1994	8074264
mutations of the tyrosinase gene in patients with oculocutaneous albinism from various ethnic groups in israel.	we have analyzed the tyrosinase (tyr) gene in 38 unrelated patients with oculocutaneous albinism (oca), derived from several different ethnic groups of the diverse population of israel. we detected tyr gene mutations in 23 of the 34 patients with apparent type i (i.e., tyrosinase-deficient) oca and in none of the patients with other clinical forms of albinism. among moroccan jews with type ia (i.e., tyrosinase-negative) oca, we detected a highly predominant mutant allele containing a missense su ...	1994	8128955
seasonal and tissue-specific regulation of canary androgen receptor messenger ribonucleic acid.	natural seasonal fluctuations in androgen levels appear to cause changes in physiology and reproductive behavior, such as singing, in canaries. little is known, however, about the cellular mechanisms underlying these changes. because androgens act principally through nuclear receptors in other species, we have isolated and sequenced a cdna likely to encode the canary androgen receptor and used this cdna to examine the regulation of ar mrna levels in the testis, kidney, and liver of the canary. t ...	1994	8299561
[perceived morbidity and the use of medical consultations in telde (grand canary)].	to find the extent of perceived morbidity and the population's main reasons for seeking medical care.	1993	8329549
[intake of pollutants (heavy metals) via total diet at the national level as a whole and in autonomous communities: a new approach].	as an answer to the request of information on the real intake of pollutants, both who and fao recommend its study through the study of total diet. following their criteria we have determined the contents of arsenic, cadmium, mercury and lead in the total mean spanish diet and in the seventeen autonomous regions, comparing them with the acceptable daily intakes (adi). at the same time it is studied the contribution of the different groups of nutrients to the total pollutant charge. there is no de ...	1993	8341819
the gastrointestinal tract. the canary of the body?		1993	8355390
direct evidence for loss and replacement of projection neurons in adult canary brain.	normally occurring projection neuron loss and replacement were quantified over a 6 month period in the pathway from the high vocal center (hvc) to the robust nucleus of the archistriatum (ra) in adult male canaries. fluorescent latex microspheres were injected into ra in april--a procedure resulting in long-term retrograde labeling of ra-projecting hvc neurons. labeled cell densities were then obtained 4 and 20 d later in april and 195 d later in october. we found that 41-49% of the ra-projectin ...	1993	8385206
relationships between characteristics of exposure to pigeon antigens. clinical manifestations and humoral immune response.	an extensive clinical study has been performed on pigeon breeders in the canary islands. three hundred forty-three subjects have participated in this study through the filling of a clinical and epidemiologic questionnaire. a venous blood sample was also taken from each fancier for a further serologic analysis. detection of specific igg antibodies was made by an indirect enzyme-linked immunosorbent assay (elisa) using pigeon serum as antigenic material. twenty-nine (8 percent) breeders fulfilled ...	1993	8131438
epidemiology of proximal femoral fracture in gran canaria (canary islands).	an epidemiological survey of proximal femoral fracture (pff) was carried out in gran canaria (canary islands) in 1990. we identified 211 cases of pff affecting residents, which gave an incidence of 161 per 100,000 per year (92 per 100,000 per year for men and 176 for women). three quarters of all fractures occurred to residents of urban areas and nearly all fractures were caused by falls indoors. there was a higher incidence in winter than in summer months.	1993	8213335
migration of newly generated neurons upon ependymally derived radial guide cells in explant cultures of the adult songbird forebrain.	the adult songbird forebrain undergoes neuronal production throughout adulthood, with the production of new neurons in discrete regions of the neostriatal ventricular zone. upon mitogenesis, these new neurons migrate into the subjacent brain parenchyma along radially directed guide fibers. in long-term ventricular zone explant cultures, derived from the higher vocal center of the adult canary, newly migratory neurons were found to associate preferentially with a characteristic substrate cell typ ...	1993	8225557
[hemoglobinopathies and thalassemias in the hindu settlement established in the canary islands].		1993	8235954
yolk is a source of maternal testosterone for developing birds.	the sex steroid hormones that affect development in birds have been thought to be produced exclusively by the embryo or neonate. i used radioimmunoassay to measure the amounts of androstenedione, 5 alpha-dihydrotestosterone, testosterone, 17 beta-estradiol, and corticosterone in the yolk of freshly laid canary (serinus canaria) and zebra finch (poephila guttata) eggs. testosterone was found in both canary and zebra finch eggs, but its contents were much higher in the former than in the latter. t ...	1993	8265571
hb porto alegre or alpha 2 beta 29(a6)ser->cys in unrelated families of the canary islands.		1993	8294204
antibiotic and cytotoxic activity of brominated compounds from the marine sponge verongia aerophoba.	analysis of the marine sponge verongia aerophoba from the canary islands afforded eight brominated secondary metabolites including the small molecular weight compounds aeroplysinin-1 (5) and the dienone (7) which were previously shown to arise by enzymatically catalyzed degradation of aerophobin-2 (4) and isofistularin-3 (1) following breakdown of the cellular compartmentation of the sponge. all compounds were identified from their nmr and mass spectra. aeroplysinin-1 as well as dienone which ar ...	1993	8297426
peptide mapping analysis of group i allergens of grass pollens.	group i allergens, from eight different clinically important grass pollens of the pooideae (rye-grass, canary, kentucky bluegrass, orchard and timothy), chloridoideae (bermuda grass) and panicoideae (johnson grass, maize) were isolated by sodium dodecyl sulphate polyacrylamide gel electrophoresis and subjected to limited partial proteolysis and cyanogen bromide cleavage. the generated digests were visualised on gels by silver staining. replicate gels were blotted and screened with lolp i-specifi ...	1993	7691298
[late hereditary degenerative sensorineural hearing loss associated with iga mesangial glomerulonephritis of probable autosomal dominant heredity].	we studied four generations of a canary islands family presenting a tardive heredodegenerative hearing loss, associated with iga mesangial glomerulonephritis, of probable autosomal dominant heredity. with respect to the family, we revised alport's syndrome, for possible transmission associated with x chromosome, as well as heredodegenerative hearing loss associated with renal pathology of autosomic transmission currently described; we differentiate these hearing losses from our case study, and w ...	1993	8155361
estrogen receptors in the avian brain: survey reveals general distribution and forebrain areas unique to songbirds.	estrogens play an important role in the control and differentiation of species-typical behavior and in endocrine homeostasis of birds, but the distribution and evolution of cells that contain estrogen receptors in the avian brain are poorly understood. this study therefore surveys 26 species in the avian orders anseriformes (1 species), galliformes (2), columbiformes (3), psittaciformes (1), apodiformes (2), and passeriformes (3 suboscines, 14 oscines). indirect immunocytochemistry with the estr ...	1993	8432903
a frequent tyrosinase gene mutation associated with type i-a (tyrosinase-negative) oculocutaneous albinism in puerto rico.	we have determined the mutations in the tyrosinase gene from 12 unrelated puerto rican individuals who have type i-a (tyrosinase-negative) oculocutaneous albinism (oca). all but one individual are of hispanic descent. nine individuals were homozygous for a missense mutation (g47d) in exon i at codon 47. two individuals were heterozygous for the g47d mutation, with one having a missense mutation at codon 373 (t373k) in the homologous allele and the other having an undetermined mutation in the hom ...	1993	8434585
cystic fibrosis in spain: high frequency of mutation g542x in the mediterranean coastal area.	we have determined the frequency of deletion delta f508 and mutation g542x, a nonsense mutation in exon 11 of the cystic fibrosis (cf) gene, in a sample of 400 spanish cf families. mutation g542x represents 8% of the total number of cf mutations in spain, making it the second most common mutation after the delta f508 deletion, which accounts for 48% of cf chromosomes. g542x has a higher frequency in the mediterranean coastal area (14%) and in the canary islands (25%). about 70% of g542x chromoso ...	1993	8454290
neurogenesis in adult canary telencephalon is independent of gonadal hormone levels.	neurons generated in adulthood are found throughout the canary telencephalon. we are interested in the factors that control the rate of proliferation of stem cells that give rise to these new neurons. the rate of incorporation of newly generated neurons into vocal-control regions varies seasonally. this difference could reflect a higher rate of neurogenesis, a lower rate of cell death, or an altered migration. we examined the incidence of thymidine-labeled cells in the telencephalic ventricular ...	1993	8478689
geographical variations in the prevalence of hiv infection among drug users receiving ambulatory treatment in spain.	to identify the factors responsible for the regional differences in hiv-positive serostatus among drug users in spain receiving outpatient treatment, the 17 autonomous regions into which spain is divided were classified as high (mean 52%) or low prevalence groups (mean 34%) depending on the prevalence of seropositivity. in regions where the prevalence of positive serostatus was high, unemployment was more markedly associated with hiv infection than in low prevalence regions, while other potentia ...	1993	8505189
[prevalence of ischemic cardiopathy risk factors on the island of lanzarote].	as a fruit of complex interaction of factors, coronary atherosclerosis constitutes the first cause of death in the developed countries.	1993	8510475
testosterone-induced changes in adult canary brain are reversible.	brain nuclei that control song are larger in male canaries, which sing, than in females, which sing rarely or not at all. treatment of adult female canaries with testosterone (t) induces song production and causes song-control nuclei to grow, approaching the volumes observed in males. for example, the higher vocal center (hvc) of adult females approximately doubles in size by 1 month following the onset of t treatment. male hvc projects to a second telencephalic nucleus, ra (the robust nucleus o ...	1993	7686962
molecular cloning and characterization of cdnas associated with tracheary element differentiation in cultured zinnia cells.	mesophyll cells isolated mechanically from leaves of zinnia elegans l. cv canary bird differentiate into tracheary elements (te) semisynchronously and at high frequency. using this system, three cdna clones, ted2 to ted4, whose corresponding mrnas were expressed in a close association with tracheary element differentiation, were isolated by differential screening of a lambda gt11 cdna library. the library was prepared using poly(a)+ rna from cells cultured in a te-induced medium for 48 h prior t ...	1993	8022937
uv-induced alterations in skin and lymphocytes during a one-week holiday in the canary islands in may.	the effect of solar exposure during a one-week sunbathing vacation in may at 29 degrees n latitude was investigated in 22 volunteers. the following end-points were measured before and after the holiday: skin reflectance at 507 nm, transmission of radiation from 289 nm to 448 nm through the epidermis, epidermal thickness, minimal erythema dose (med), total white cell, neutrophil, lymphocyte, and lymphocyte subpopulation counts in blood, spontaneous dna synthesis, dna strand breaks and sister-chro ...	1993	7906452
toxin detection using a tyrosinase-coupled oxygen electrode.	an enzyme-based "electrochemical canary" is described for the detection of cyanide. the sensing system imitates cyanide's site of toxicity in the mitochondria. the terminal sequence of electron transfer in aerobic respiration is mimicked by mediator coupling of tyrosinase catalysis to an electro-chemical system. an enzyme-coupled oxygen electrode is created which is sensitive to selective poisoning. biocatalytic reduction of oxygen is promoted by electrochemically supplying tyrosinase with elect ...	1993	8439010
effect of heliotherapy on skin and joint symptoms in psoriasis: a 6-month follow-up study.	the effect of heliotherapy on psoriasis skin lesions and arthritis was studied in a trial comprising 4 weeks of therapy in the canary islands and a 6-month follow-up period. a total of 373 patients participated in the heliotherapy and 361 patients completed the follow-up period. the severity of skin lesions was evaluated using a psoriasis severity index (psi), and that of the arthropathy by using an arthritis index (ai). during heliotherapy, the psi decreased significantly from the initial media ...	1993	8457451
implication of central neurohypophyseal hormone receptor-mediated action in timing of reproductive events: evidence from novel observations on the effect of a vasotocin analogue on singing behaviour of the canary.	a highly discrete distribution of neurohypophyseal hormone receptors was discovered in the mammalian and avian brain. these receptors are heterogeneous. in rat brain oxytocin (ot) and v1a receptors can be distinguished which bind ot with an order of magnitude difference in affinity and which are located in discrete sites of the limbic-midbrain circuitry. in the brain of the canary low and high affinity vasotocin (vt) sites were identified; the latter putative vt receptors were found exclusively ...	1993	8390083
identification of canary grass (phalaris aquatica) pollen allergens by immunoblotting: ige and igg antibody-binding studies.	the pollen of canary grass, which was introduced as a pasture grass from europe, is a major allergen in the external environment of southern australia. seventeen allergenic fractions of canary grass pollen, ranging in mol. mass from 14 to 100 kda, have been identified by immunoblotting, using ige antibodies from sera of 24/30 grass-pollen-allergic subjects. the highest frequency of ige binding (77%) was to a major 34-kda fraction (tentatively designated pha a i). this protein has been partially ...	1993	7687099
papillomavirus-like infections in canaries (serinus canarius).	a papillomavirus-like infection in canaries (serinus canarius) is described. papillomatous epithelial proliferations were observed at the commissure of the beak and on the head. histologically, stratified squamous epithelium covered with a hyperkeratotic layer and intranuclear inclusions were observed. electron microscopically, intranuclear aggregates of papilloma-like virus particles were demonstrated.	1993	18671063
human enzyme polymorphism in the canary islands. v. western islands.	autochthonous human samples of the three westernmost islands of the canarian archipelago, la palma, gomera, and hierro, have been analyzed for eight red cell polymorphic enzymes. only a small intra and inter-insular differentiation exists among these three islands. however, a marked heterogeneity is found when all seven islands of the archipelago are compared by nei's genetic distances [1972]. nevertheless, there is no correlation between genetic and geographic distances. historical factors coul ...	1992	1339492
respiratory allergies and skin test reactivity in high school students in tenerife, canary islands, spain.	the prevalence of skin test reactivity to 22 aeroallergens and of allergic respiratory diseases was determined in 501 high school students on the island of tenerife, spain. two hundred seventy-seven students (55.2%) had at least one positive prick skin test (wheal > or = 2 mm). two hundred sixteen students (43.1%) had symptoms of upper or lower respiratory tract allergies [24 (4.7%) had asthma with or without rhinitis and 192 (38.3%) seasonal or perennial rhinitis alone]. two hundred eighty-five ...	1992	1342878
effect of psoriasis heliotherapy on epidermal urocanic acid isomer concentrations.	a noninvasive finn chamber sampling method and hplc analysis were used to determine epidermal urocanic acid (uca) concentrations of psoriasis patients during 4 weeks of heliotherapy on the spanish canary islands and a follow-up period of 8 weeks. during heliotherapy the epidermal cis-uca concentration increased from a mean initial value of 0.2 nmol/cm2 to a mean final value of 2.9 nmol/cm2. the total uca concentration decreased during the first week of heliotherapy from an initial value of 5.5 n ...	1992	1357870
differential regulation in the avian song control circuit of an mrna predicting a highly conserved protein related to protein kinase c and the bcr oncogene.	an rna identified by differential cdna cloning (hat-2) is highly enriched in canary forebrain in areas associated with the control of complex learned behaviors and higher perceptual processes. the nucleotide sequence predicts a protein that is 96% identical to the product of the n-chimaerin gene isolated from human brain and contains two identifiable domains suggesting a novel role in signal transduction processes. one domain is similar to the sequence in protein kinase c which mediates diacylgl ...	1992	1374499
solar ultraviolet (uv) radiation and uv doses received by patients during four-week climate therapy periods in the canary islands.	the ultraviolet (uv) radiation doses received by 270 psoriasis patients were studied during 4-week climate therapy periods in november, march or april in the canary islands. the daily total solar uv radiation (ambient radiation load, arl) was measured using frequent readings with a robertson-berger sunburning ultraviolet (suv) meter. a daily personal radiation load (prl) was calculated for each patient, using sun exposure diary data. to measure the cumulative uv exposure of particular skin sites ...	1992	1390124
[seroprevalence of q fever among the adult population of lanzarote (canary islands)].	q fever is an endemic zoonosis in the canary islands. in 1986, we detected, in a pilot study, residual antibodies of the infection in 3% of the population from lanzarote. in 1989, we performed a new study in order to assess seroprevalence of q fever among the adult native population from the island. we studied 390 human serums obtained from an statistically representative sample. age ranged from 30 to 64 years. out of 390 serums, 196 (50.25%) were obtained from men and 194 (49.74%) from women. t ...	1992	1391577
newly generated neurons of the adult songbird brain become functionally active in long-term culture.	the vocal control nucleus, hvc, of the songbird forebrain undergoes neurogenesis in adulthood, as ventricular zone precursor cells divide and their daughter cells migrate into the subjacent forebrain, where they differentiate into neurons. we have previously demonstrated that the migration and development of these new neurons can proceed in vitro, in hvc ventricular zone explant cultures derived from the adult canary hvc. by a combination of electron microscopy and electrophysiology, we now repo ...	1992	1394968
immunoreactive vasotocin in the zebra finch brain (taeniopygia guttata).	the distribution of vasotocin (vt)-immunoreactive cells and fibers in the zebra finch brain was studied with immunocytochemical techniques. a large number of vt-immunoreactive cells was found in the nucleus preopticus anterior and nucleus paraventricularis. in the lateral parts of the hypothalamus diffusely organized vt-immunoreactive cells were present. some of these cells were found close to and embedded in the optic tract. an extra-hypothalamic parvocellular cell group was found at the level ...	1992	1424081
hormone accumulation in song regions of the canary brain.	[3h]testosterone (t) was injected into male and female canaries (serinus canarius), a species in which females are able to sing but do so more rarely and more simply than males. autoradiographic analysis revealed that males and females have equal proportions of cells labeled by t or its metabolites in four song control nuclei: the high vocal center (hvc), the lateral portion of the magnocellular nucleus of the anterior neostriatum (iman), the robust nucleus of the archistriatum (ra), and the hyp ...	1992	1431849
ancient skeletal remains of the canary islands: bone histology and chemical analysis.	prehispanic burials from the canary islands are often well preserved. many of the bodies are mummified, most of them were not interred, but deposited in caves. bone histological and trace element analysis of 117 skeletons of the prehispanic period of the canary islands was performed. in some of the islands we have found a high prevalence of osteoporosis, whereas in others, histomorphometrically assessed trabecular bone mass (tbm) (in undecalcified iliac crest specimens) was in the normal range. ...	1992	1444274
comparison of the antipsoriatic efficacy of heliotherapy and ultraviolet b: a cross-over study.	ten psoriasis patients who underwent a 4-week heliotherapy period in the canary islands were treated with ultraviolet b (uvb) phototherapy at relapse, 2-24 months later. in both settings, psoriasis improvement was monitored using a psoriasis severity index (psi), and uv exposure was recorded with polysulphone films. in the 8 patients that could be evaluated, a median healing rate of 94% was recorded in the heliotherapy period, with a median cumulative uv dose of 46 erythemal units (eu). in the u ...	1992	1489722
song presentation induces gene expression in the songbird forebrain.	we investigated the participation of genomic regulatory events in the response of the songbird brain to a natural auditory stimulus of known physiological and behavioral relevance, birdsong. using in situ hybridization, we detected a rapid increase in forebrain mrna levels of an immediate-early gene encoding a transcriptional regulator (zenk; also known as zif-268, egr-1, ngfi-a, or krox-24) following presentation of tape-recorded songs to canaries (serinus canaria) and zebra finches (taeniopygi ...	1992	1495970
[leprosy: identification of an isolated case].	leprosy is an infrequent disease in spain. 4,714 cases of leprosy was registered in the last national census (1979). the disease is still common in certain regions, such as levant, andalusia, extremadura, canary island and galicia. lepromatous type is more frequent, a typical hallmark of endemies with low activity or characterized by regression. we report a patient affected of borderline lepromatous leprosy with the following characteristics: 1) the only known case in his locality, 2) lack of re ...	1992	1546198
auditory perception of conspecific and heterospecific vocalizations in birds: evidence for special processes.	budgerigars (melopsittacus undulatus), canaries (serinus canaria), and zebra finches (poephila guttata castanotis) were tested for their ability to discriminate among distance calls of each species. for comparison, starlings (sturnus vulgaris) were tested on the same sounds. response latencies to detect a change in a repeating background of sound were taken as a measure of the perceptual similarity among calls. all 4 species showed clear evidence of 3 perceptual categories corresponding to the c ...	1992	1555398
immunocytochemical localization of androgen receptors in the male songbird and quail brain.	the distribution of androgen receptors was studied in the brain of the japanese quail (coturnix japonica), the zebra finch (taeniopygia guttata), and the canary (serinus canaria) by immunocytochemistry with a polyclonal antibody (ar32) raised in rabbit against a synthetic peptide corresponding to a sequence located at the n-terminus of the androgen receptor molecule. in quail, androgen receptor-immunoreactive cells were observed in the nucleus intercollicularis and in various nuclei of the preop ...	1992	1578004
trace metals in limpets (patella sp) from the coast of santa cruz de tenerife (canary islands).		1992	1581679
evaluation of selected plants for their toxic effects in canaries.	leaves or fruit from 14 plants considered to be toxic to pet birds were administered by gavage to 15 pairs of canaries (serinus canaria). each bird was given 0.12 to 0.70 g of plant material. one pair served as a control and was given distilled water. the plant materials were flash-frozen in liquid nitrogen, pulverized, and resuspended in deionized water for administration. of the plants tested, 5 (oleander, lupine, foxglove, yew leaves, and dieffenbachia) were considered highly toxic and were a ...	1992	1601714
[epidemiology of respiratory syncytial virus infections in the canary islands].	respiratory syncytial virus (rsv) is the major cause of lower respiratory tract infection in young children. outbreaks of rsv infection occur yearly during the winter or spring in temperate climates. our study of 634 hospitalized children under 3 years of age with bronchiolitis and pneumonia (november 1988 to january 1990) revealed that 227 (35.8%) had vrs infections. these cases showed a yearly epidemic pattern with 86.8% of the cases occurring during the winter. furthermore, 67.4% of the cases ...	1992	1605415
in vitro neurogenesis by neuronal precursor cells derived from the adult songbird brain.	the vocal control nucleus of the adult songbird forebrain, hvc, exhibits de novo neurogenesis in adulthood, with the production of new neurons from precursor cells located in the overlying ventricular zone (goldman and nottebohm, 1983). we previously established that explants derived from neurogenic regions of the adult canary forebrain could be maintained in vitro, under conditions that permitted the migration and differentiation of those new neurons previously generated in vivo (goldman, 1990) ...	1992	1613545
screening and confirmation of drugs in urine: interference of hordenine with the immunoassays and thin layer chromatography methods.	hordenine cross-reacted with various enzyme linked immunosorbent assay (elisa) or radioimmunoassay (ria) kits used for the screening of urine samples. morphine-elisa kit was most sensitive, whereas etorphine- and buprenorphine-elisa kits were least sensitive to hordenine cross-reactivity. hordenine also interfered with the thin layer chromatography of oxymorphone, hydromorphone and apomorphine. the major source of hordenine in humans is beer brewed from barley, whereas the major source of horden ...	1992	1618458
community health nurse: canary in a mine shaft?		1992	1630715
testosterone facilitates some conspecific song discriminations in castrated zebra finches (taeniopygia guttata).	an experiment was designed to test for the influence of testosterone on song discriminations. we found that testosterone did have an effect, which interacted with practice and the nature of the stimuli. fourteen adult castrated zebra finches (taeniopygia guttata) were grouped into seven pairs. in each pair, one bird was implanted with a testosterone-filled silastic tube and the other was implanted with an empty silastic tube. they were then trained on a go/no-go operant task to discriminate betw ...	1992	1741392
an outbreak caused by mycoplasma mycoides species in goats in the canary islands.		1992	1595163
suicide in the canary islands: standardized epidemiological study by age, sex, and marital status.	the authors analyze the distribution of suicides according to the variables of sex, age and marital status in the canary islands, during the period 1977-1983, by means of a register that they themselves created in order to correct serious deficiencies in the official data. there were notable differences between men and women, and the tendencies observed in each case are also very different. the authors argue that this makes it necessary to separate the sexes in the epidemiological studies on sui ...	1992	1594975
distribution of protein phosphatase inhibitor-1 in brain and peripheral tissues of various species: comparison with darpp-32.	the distribution of inhibitor-1, a cyclic amp-regulated inhibitor of protein phosphatase-1, was analyzed in various brain regions and peripheral tissues of various species by immunolabeling of sodium dodecyl sulfate-poly-acrylamide gel transfers using specific antibodies. the distribution of inhibitor-1 was directly compared to that of darpp-32, a structurally related cyclic amp-regulated inhibitor of protein phosphatase-1. in rat cns, a single immunoreactive protein of m(r) 30,000, identified a ...	1992	1353788
chemical constituents of the lichen ramalina hierrensis.	the following compounds have been isolated from the lichen ramalina hierrensis, collected on savin, and endemic to the canary islands: ursolic acid, iso-arborinol acetate, beta-sitosterol, ergosterol peroxide, cerevisterol, (-)-sandaracopimaric acid, parietin, (+)-usnic acid, (+)-iso-usnic acid, divaricatic acid, atranorin, stictic acid, gangaleodin, variolaric acid, montagnetol, and hierridin. the structures of all compounds were elucidated by physical, spectral, and chemical methods.	1992	17226459
the volatiles of two bystropogon species from the canary islands (spain).	the essential oils of two bystropogon species of the mint family endemic to the canary islands (spain) have been analyzed by a combination of glc/ms, retention indices, 1r, (13)c-nmr and (1)h-nmr spectra. the major components of the volatile oils were found to be pulegone, isomenthone, and methone in b. origanifolius and 3-octyl acetate, limonene, and trans-beta-caryophyllene in b. canariensis.	1992	17226504
treatment of wastewater effluents with phillipsite-rich tuffs.	the presence of abundant zeolites in association with volcanic pumiceous materials in tererife (canary islands) prompted us to study their properties as a water purifying bed for inorganic contaminants, pathogenic bacteria, and soluble organic matter. the experimental model used was a chemical percolation reactor with a constant flux of solution, where the fixation kinetics were studied by comparing the input and the output solutions. the ammonium and phosphate retention values found after 10 da ...	1992	15091986
[european expansion and aboriginal demographics. the example of the canary islands, 1400-1505].	the author examines the indigenous population of the canary islands from the thirteenth century to 1505. he uses the limited available data to describe the effect of contact with and eventual colonization by spain on such aspects as spatial distribution, mortality, and forced labor migration to the continent. comparisons are made with the indigenous experience in the americas.	1992	12285699
[the demography of an atlantic island population. grand canary, 1680-1850].	the author applies inverse projection methods to data from baptism and death records for the parishes of the island of grand canary from 1680 up to the cholera epidemic of 1851. the relationships among the economy, migration, and other demographic parameters for this isolated population are assessed. he concludes that the island population was not greatly affected by emigration to the americas until the late eighteenth century, and that a high birth rate combined with low levels of mortality w ...	1991	12317192
a well-rounded worm: roundworm as canary?		1991	17751971
human enzyme polymorphism in the canary islands. iv. eastern islands.	the genetic polymorphism of eight red cell enzymes was analyzed in four population samples from the two easternmost islands of the canary archipelago. no heterogeneity was detected within the islands, but differences between them were of the same magnitude as those found between the islands and the spanish mainland. the presence of the african g6pd-a+ and the rare g6pd-gc alleles seems to be a characteristic of all canarian populations studied.	1991	1797632
altered daylength affects dendritic structure in a song-related brain region in red-winged blackbirds.	substantial neural and behavioral plasticity occurs in the avian song system in adulthood. changes in the volume of one of the song control nuclei, robustus archistriatalis (ra), have been associated with seasonal changes in singing behavior in adult canaries (serinus canarius) and red-winged blackbirds (agelaius phoeniceus). the present work assessed the effects of changed daylength on dendritic morphology in ra in adult male red-winged blackbirds. brains from hand-reared red-winged blackbirds ...	1991	1759944
[hereditary sideroblastic anemia in 3 canary island families].		1991	1776117
suicide in the canary islands, 1977-1983.	we studied suicide in the canary islands between 1977 and 1983 and found 775 cases, twice the official number of 381. this indicates the lack of validity and reliability of official figures for suicide in spain today. the figures reveal an upward trend in the canary islands, with the annual rate of 6.81 per 100,000 in 1977 having increased to 10.64 per 100,000 in 1983. there were no significant differences in the frequency of suicide according to season, month or day of the week.	1991	1792925
allergy to limpet.	allergy to mollusk has rarely been described. the limpet, belonging to phylum mollusca, is one of the most frequent mollusks in the canary islands, as in all warm maritime regions. we report two cases of atopic patients who developed anaphylactic reactions after ingestion of this mollusk. type i hypersensitivity to limpet antigens was demonstrated by means of immediate skin test reactivity, specific ige determination by rast, and histamine release test to cooked limpet extract. the controls did ...	1991	1796776
neurotoxic envenoming by an immigrant spider (steatoda nobilis) in southern england.	a young woman was bitten on the shoulder by a female steatoda nobilis spider, in worthing on the south coast of england. she noticed intense radiating pain, local sweating (indicating parasympathetic stimulation) and feverishness. this immigrant species from the canary islands has established itself along the south coast of england in recent years. like the related mediterranean species s. paykulliana, s. nobilis may be of medical importance and deserves further study.	1991	1801319
effect of a vasotocin analog on singing behavior in the canary.	groups of juvenile and 1-year-old male canaries were treated briefly with the vasotocin (vt) analog desgly(nh2)9d(ch2)5-[tyr(me)2,thr4, orn8]vt (dgvta) during four time intervals between september and february. the canaries received subcutaneously testosterone-containing silastic implants at the start of the vt analog treatment to assure that despite age and season differences the birds would all have comparable plasma levels of testosterone. the vt analog was administered subcutaneously (0.7 mi ...	1991	1813380
the coalminer and the canary.		1991	1838380
[epidemiology of tuberculosis in the gran canary island].	the aim of the present study was to obtain information about tuberculosis (tb) in our area that might contribute to assess the status in spain.	1991	1857150