Publications

single oral dose metronidazole therapy for gardnerella vaginalis vaginitis in adolescent females.	this study briefly reviews gardnerella vaginalis as a primary vaginal pathogen and assesses the efficacy and safety of therapy with a single, 2-g oral dose of metronidazole. over a period of 20 months, 882 symptomatic adolescent girls had positive cultures for g. vaginalis. all were post-menarcheal. no other vaginal pathogen was isolated in 609. the total group had a second culture 5-7 days after treatment. cultures taken after treatment were negative in 95% of those treated with a single 2-g do ...	1983	6345494
gardnerella vaginalis-associated vaginitis--a 'new' sexually transmitted disease.		1983	6345982
[sensitivity of gardnerella vaginalis to antibiotics. study of 40 strains isolated at the purpan university hospital center of toulouse].	40 strains of gardnerella vaginalis were tested for their in vitro susceptibility to 10 antibiotics, by an agar dilution method. all strains were inhibited by 0,5 microgram or less of penicillin and ampicillin. erythromycin was the most active of the antibiotics tested; for all strains the minimal inhibitory concentrations were less than or equal to 0.06 microgram/ml. all strains were inhibited by 8 micrograms of streptomycin per ml and 4 micrograms of chloramphenicol per ml. 50% of the strains ...	1983	6348664
a placebo-controlled, double-blind comparison of tinidazole and triple sulfonamide cream for the treatment of nonspecific vaginitis.	oral tinidazole, 500 mg twice daily for 5 days, was compared to triple sulfonamide cream inserted into the vagina twice daily for 7 days for the treatment of nonspecific vaginitis in a placebo-controlled, double-blind trial. at 1 and 3 weeks after treatment, 29 of 30 and 18 of 19 patients, respectively, who had been given tinidazole were cured, as compared to 16 of 27 and 6 of 14 patients, respectively, who had been given oral placebo together with a vaginal cream with or without sulfonamides (p ...	1983	6351619
anaerobic bacteria as cause of infections in female genital organs.	anaerobic bacteria constitute a substantial component of the normal vaginal flora and of the outer cervical canal. consequently, one would expect infections emanating from the vaginal flora to be caused to a substantial degree by anaerobic bacteria. the anaerobes may contribute in colpitis, but their role is difficult to prove in this situation, since sampling only yields normal flora components. one clue that anaerobes may contribute to colpitis is the circumstance that the flora under those co ...	1983	6353553
nonspecific vaginitis in an outpatient clinic. comparison of three dosage regimens of metronidazole.	nonspecific vaginitis causes diagnostic as well as therapeutic difficulties in gynecological private practice. in a study in 63 patients with "nonspecific" vaginitis, clinical parameters were related to the bacteriological isolation of g. vaginalis in order to try to find criteria which can help to make a correct diagnosis of "nonspecific vaginitis". these patients were treated with three different regimens of metronidazole, either 2000 mg as a single dose, or two single doses of 2000 mg each ta ...	1983	6364329
a dose-duration study of metronidazole for the treatment of nonspecific vaginosis.		1983	6364332
treatment of non-specific vaginitis with a single dose of tinidazole.	in a double-blind, randomized trial twenty-six patients with non-specific vaginitis were treated with tinidazole/placebo (4 x 500 mg in one single dose). thirteen patients received placebo, of which one was cured. thirteen patients received tinidazole, of which six were cured. the nineteen non-responders received tinidazole (4 x 500 mg in one single dose), which resulted in the cure of eight patients (seven from the original placebo-group and one from the original tinidazole-group). of the eleve ...	1983	6364333
comparison of two different regimens of metronidazole in the treatment of non-specific vaginitis.	25 patients with symptoms of non-specific vaginitis have been treated with metronidazole either 2000 mg in a single dose or 400 mg three times daily for 5 days. diagnosis was settled by 1) identification of g. vaginalis in culture of vaginal secretion, 2) the observation of clue cells in wet smear, 3) a positive amine test on application of potassium hydroxide, and 4) increased ph in the vaginal secretion. most patients' symptoms and complaints disappeared and at the same time most of the tests ...	1983	6364334
gardnerella vaginalis: pathogen or commensal?		1983	6134952
gardnerella vaginalis.		1983	6135858
anaerobic vaginosis (non-specific vaginitis): clinical, microbiological, and therapeutic findings.	the effect of metronidazole on anaerobic vaginosis (non-specific vaginitis) was assessed in a double-blind, placebo-controlled study of 40 women. 19 of 20 women given metronidazole 400 mg twice a day for seven days were clinically and microbiologically cured by the time they completed treatment. all 20 women given a placebo were treatment failures, but when they were given a single 2 g dose of metronidazole, 15 showed clinical and microbiological cure a week later. 14 of the responders showed a ...	1983	6140492
diagnosis of bacterial vaginosis by direct gram stain of vaginal fluid.	to determine whether bacterial vaginosis (bv), also known as nonspecific vaginitis, could be diagnosed by evaluating a gram stain of vaginal fluid, we examined samples from 60 women of whom 25 had clinical evidence of bv and 35 had candidal vaginitis or normal examinations. an inverse relationship between the quantity of the lactobacillus morphotype (large gram-positive rods) and of the gardnerella morphotype (small gram-variable rods) was noted on gram stain (p less than 0.001). when gram stain ...	1983	6193137
in vitro activity of seventeen antimicrobial agents against gardnerella vaginalis.	the in vitro activity of 17 antimicrobial agents was tested against 25 clinical isolates of gardnerella vaginalis. minimum inhibitory concentrations were determined by agar dilution. the isolates were sensitive to penicillin, ampicillin, ticarcillin, piperacillin, cephalothin, cefoxitin, cefotaxime, cefoperazone, n-formimidoyl-thienamycin, chloramphenicol, clindamycin and erythromycin. mic90 for the beta-lactam antibiotics ranged from 0.12 mg/l for penicillin to 2 mg/l for ticarcillin. cefoperaz ...	1982	6223813
vaginitis in sexually active women: relationship to nine sexually transmitted organisms.	women seen for symptoms suggestive of vulvovaginitis were studied for the detection of mycoplasma hominis. ureaplasma urealyticum, yeast, neisseria gonorrhoeae, chlamydia trachomatis, gardnerella vaginalis, herpes simplex virus, group b beta-hemolytic streptococci, aerobes, anaerobes, and trichomonas vaginalis. asymptomatic women who reported to be sexually active and agreed to undergo comprehensive genital cultures were used as controls. there was a significant association of vulvovaginitis wit ...	1982	6280502
polymicrobial nature of vaginitis in young women: a microbiological and therapeutic study.	thirty-six young females attending the student health service with vaginitis were investigated by serial semiquantitative aerobic, anaerobic, fungal, mycoplasma and viral cultures over a 10 day period and results were correlated with signs and symptoms. antifungal therapy (econazole pessaries and cream) resulted in clearance of candida from 13 out of 16 patients where there was no increase in the anaerobic flora. in the four subjects where candida was isolated along with gardnerella vaginalis pl ...	1982	6283441
sensitivity of gardnerella vaginalis to metabolites of metronidazole and tinidazole.		1982	6119542
comparison of bacterial and fungal adherence to vaginal exfoliated epithelial cells and human vaginal epithelial tissue culture cells.	the adherence of four bacterial species and candida albicans to a new in vitro tissue culture model of human vaginal stratified squamous epithelium was investigated and compared with in vitro adherence to vaginal exfoliated cells. gardnerella vaginalis, group b streptococci, lactobacillus sp., and c. albicans adhered well to both exfoliated and tissue culture cells. similarly, a piliated fecal isolate of escherichia coli, but not a nonpiliated vaginal isolate of e. coli, adhered well to both cel ...	1982	6120141
gardnerella vaginalis, anaerobes, and vaginal discharge.		1982	6123676
gardnerella vaginalis: laboratory isolation and clinical significance.		1982	6756626
classic illustration.		1982	6761190
identification of gardnerella vaginalis by a fluorescent antibody test.		1982	6762799
gardnerella vaginalis and its clinical syndrome.	the gardnerella vaginalis syndrome is a well defined but benign condition characterized by a smelly vaginal discharge of ph greater than 5.0. it is not associated with inflammation. it often occurs in association with cervical infections. the microscopic appearance of the discharge is typical and diagnostic. the wet mount shows "clue cells" and "rafts" (floating clumps of small bacilli) and the gram stain has the "pepper on salt" pattern of masses of small gram-variable bacilli. the amine test i ...	1982	6764199
the odour of non-specific vaginitis: a review.		1982	6764200
an overview of the diagnosis and treatment of gardnerella vaginalis and bacteroides associated vaginitis.		1982	6764201
selective differential human blood bilayer media for isolation of gardnerella (haemophilus) vaginalis.	new selective and differential human blood bilayer agar media with tween 80 (hbt medium) or without tween 80 (hb medium), developed for the isolation of gardnerella (haemophilus) vaginalis, permitted significantly higher g. vaginalis isolation rates than have been obtained for other media used for this purpose. hb medium consists of a basal layer of columbia agar base containing colistin and naladixic acid with added amphotericin b and an overlayer of the same composition plus 5% human blood. hb ...	1982	6764766
aetiology and management of non-specific vaginitis.	in a study of 100 women with non-specific vaginitis, characterised by a vaginal discharge which was malodorous and pruritic in most cases and caused dyspareunia and dysuria in some, gardnerella vaginalis was isolated in 46% of patients. when present, g vaginalis was significantly associated with mycoplasma hominis and bacteroides species. isolation of g vaginalis was unrelated to the presenting symptoms. treatment with povidone-iodine pessaries for two weeks produced no pronounced benefit, eithe ...	1982	7034858
rapid microbiochemical method for identification of gardnerella (haemophilus) vaginalis.	a rapid biochemical method for the identification of gardnerella vaginalis has been developed. the method is based on the fermentation of starch and raffinose and on the hydrolysis of hippurate. with this new procedure, identification was confirmed for 390 of 396 g. vaginalis isolates within 1 h after their inoculation into the three substrates.	1982	7050164
[gardnerella vaginalis. a common cause of leukorrhea and colpitis?].		1982	7123520
chlamydia trachomatis infections in women with urogenital symptoms.	chlamydia trachomatis was isolated from 30 to 100 women attending a family physician's office with dysuria, frequency or vaginal discharge, compared with 2 of 30 asymptomatic women. multiple infections were common: c. trachomatis coexisted with gardnerella vaginalis, candida albicans, trichomonas vaginalis or a bacterial cause of urinary tract infection in 15 patients. c. trachomatis was isolated alone from 15 symptomatic women. the source of the positive culture was not always the site of sympt ...	1982	7139448
balanoposthitis associated with gardnerella vaginalis infection in men.	fourteen of 194 (7.2%) consecutive unselected men had positive culture results from genital swabs for gardnerella vaginalis. a higher yield of isolates was obtained from preputial (93%) than from urethral swabs (64%). of the 14 men, two had no detectable genital abnormality, eight non-gonococcal urethritis, and nine balanoposthitis. the urethral isolation rates for g vaginalis in men with and without non-gonococcal urethritis were not significantly different, but preputial isolation rates were s ...	1982	6978164
treatment of hemophilus vaginalis vaginitis.		1982	6979017
method for isolation of gardnerella vaginalis (haemophilus vaginalis). characterization of isolates by gas chromatography.	a method for the isolation of gardnerella vaginalis (haemophilus vaginalis) is presented. bacteria isolated from 48-hour cultures grown on human blood agar were identified by means of beta-hemolysis, colony morphology, sensitivity to antimicrobial agents, oxydase and catalase reactions. thirty-eight clinical isolates and one test strain were examined for fatty acid composition. hexadecanoic (16:0), octadecenoic (18:1) and octadecanoic (18:0) were the major fatty acids. also present, but in minor ...	1982	6979160
comparison of culture and microscopy in the diagnosis of gardnerella vaginalis infection.	a comparison was made between human blood agar containing amphotericin b, nalidixic acid and either gentamicin or colistin for the isolation of gardnerella vaginalis from cases of non-specific vaginitis seen in a clinic for sexually transmitted diseases. the medium containing gentamicin was more inhibitory for non-gardnerella species, but not sufficiently inhibitory to allow direct plating in the clinic without spreading for single colonies. the diffuse beta haemolysis produced by g vaginalis on ...	1982	6979558
male carriage of gardnerella vaginalis.		1982	6980683
pharmacokinetics of metronidazole and its principal metabolites and their activity against gardnerella vaginalis.	the hydroxy metabolite of metronidazole was found to be more active against 21 strains of gardnerella vaginalis than the parent compound and less affected by culture in carbon dioxide. after 400 mg oral metronidazole (flagyl) plasma concentrations of the two agents were below the minimum inhibitory concentrations (mics) for most g vaginalis strains tested. with 2 g metronidazole the plasma concentrations exceeded the mics of the more sensitive strains. even with the lower dose of metronidazole c ...	1982	6980684
[incidence and clinical importance of haemophilus vaginalis (corynebacterium vaginalis) (author's transl)].	in 250 women aged between 16 and 55 years who came to a gynaecologist we looked for haemophilus vaginalis. in 9.6% it was possible to culture haemophilus vaginalis. the comparison of the differential vaginalis (v-)medium of greenwood with the starch medium of smith showed the much better resolution of the greenwood medium. in one-half of the patients with haemophilus vaginalis there was no clinical evidence of pathogenicity of the bacterium, whereas in the other half, there was only a slight sym ...	1982	6980805
in vitro susceptibility of gardnerella vaginalis and bacteroides organisms, associated with nonspecific vaginitis, to sulfonamide preparations.	recent reports suggest that anaerobic bacteroides organisms are frequently found with gardnerella vaginalis in nonspecific vaginitis. specimens taken from 96 women with vaginal discharge were tested simultaneously for these organisms. g. vaginalis was found in 73% of the specimens, bacteroides was found in 53%, and both organisms were found in 47%. sulfonamides have been widely used in the successful treatment of vaginitis. paradoxically, g. vaginalis is reported to be resistant, and it has been ...	1982	6981374
ureaplasma urealyticum in patients with acute symptoms of urinary tract infection.		1982	6981712
gardnerella vaginalis.	this case commentary describes a common cause of vaginitis which is unfamiliar to many practising doctors because its status has been determined only in recent months. the commentary is based on a patient who presented to a melbourne general practice to which the student was assigned as part of the 'infections in the community' programme.	1982	6983344
gardnerella vaginalis and non-specific vaginitis.		1982	6983437
neonatal cellulitis due to gardnerella vaginalis.		1982	6984180
[treatment of gardnerella-vaginalis-associated colpitis with metronidazole].		1982	6984793
gardnerella vaginalis (hemophilus vaginalis), an unusual cause of peritonitis in c.a.p.d.	gardnerella vaginalis is usually associated with nonspecific bacterial vaginitis. this paper presents a capd patiënt with peritonitis due to g. vaginalis. the infection route remained speculative. treatment with gentamicin was not successful while the clinical signs of peritonitis disappeared within 24 hours after starting cefazolin.	1982	6985031
gardnerella vaginalis and non-specific vaginitis. introductory remarks.		1982	6985213
comparison of microscopic and cultural findings in the diagnosis of gardnerella vaginalis infection.	the diagnosis of gardnerella vaginalis infection on the basis of microscopic and cultural findings was compared. a total of 340 specimens of vaginal secretion were gram stained and plated on a medium selective for gardnerella vaginalis. positive culture was obtained in 165 cases. microscopy was unequivocally positive in 95, doubtful in 58 and negative in 187. positive microscopy was confirmed by culture in 99%. on the other hand, 21% of the negative microscopy results gave a false negative diagn ...	1982	6985214
the vaginal microbial flora in non-specific vaginitis.	the facultative and strictly anaerobic vaginal microbial flora was investigated in 40 women with non-specific vaginitis and in 40 control women seen in private gynaecological practice. gardnerella vaginalis, anaerobic gram-negative bacilli, anaerobic gram-negative and gram-positive cocci were all associated with non-specific vaginitis (p less than 0.001), whereas lactobacilli occurred less frequently in non-specific vaginitis than in controls (p less than 0.01). the most common anaerobes were ve ...	1982	6985215
identification of gardnerella (haemophilus) vaginalis.	different tests for the identification of gardnerella (haemophilus) vaginalis and for its differentiation from catalase-negative unclassified coryneforms from the vagina were evaluated on over 200 bacterial strains, with special emphasis on optimal test conditions. a presumptive identification of g. vaginalis in the clinical laboratory can be made on the basis of colonial morphology, clear beta-hemolysis with diffuse edges on human blood bilayer-tween agar, a negative catalase test, and typical ...	1982	6821205
corynebacterium vaginale: a neglected pathogen in family practice.	in an urban practice, 76 cases of corynebacterium vaginale infection were discovered in a two year period. in retrospect, eight percent of the female patients in the practice had this organism. most of these women were symptomatic and 45% had atypical pap smears. sulfa vaginal cream was found to be ineffective in six of nine cases. various oral antibiotic treatments of both partners were compared. a ten day course of metronidazole was found to give the best result. metronidazole in one dose, amp ...	1981	21289665
corynebacterium vaginale in non-purulent vaginitis.	the diagnostic importance of a cytological evaluation of a gram-stained smear of the discharge from a case of non-purulent vaginitis (nvp) due to corynebacterium vaginale is emphasized. a battery of rapid laboratory tests designed to identify the organism on the second day of incubation with an accuracy of at least 97% is proposed. in a prospective study of 1402 patients, 310 (22%) were found to be asymptomatic carriers of c. vaginale and 42 (3%) had vaginal discharge attributable only to c. vag ...	1981	7254108
[studies into bacterial gynecological infections, with particular reference to anaerobic and micro-aerophile germs (author's transl)].	reported in this paper are 50 pyogenic infections, with anaerobic germs being cultured in 40,7 per cent of the cases, as well as 105 examinations of patients with flour, with haemophilus vaginalis having been isolated in 20 cases. widespread occurrence of such pathogens and severity of infections caused by such bacteria call for close cooperation between clinical practitioners and microbiologists, as no safe diagnosis is practicable without involvement of the latter. reference is made to possibl ...	1981	7269879
comparison of miconazole-coated tampons with clotrimazole vaginal tablets in the treatment of vaginal candidosis.	the effectiveness and acceptability of miconazole-coated tampons were compared with those clotrimazole vaginal tablets in the treatment of vaginal candidosis in 100 women. both treatments were highly effective in reducing the signs and symptoms of infection; 95% of the group treated with miconazole had negative culture results for candida species immediately after treatment compared with 86% of those treated with clotrimazole. a 17.6% recurrence rate of positive culture results was found four we ...	1981	7272707
anaerobic and other fastidious microorganisms in asymptomatic bacteriuria in pregnant women.	urine from 44 pregnant women with known or suspected renal disease (group 1) and from 50 healthy pregnant women (group 2) with negative routine cultures of midstream urine was obtained by suprapubic aspiration. aerobic and anaerobic cultures showed bacteriuria in 70% of the women in group 1 and in 26% of those in group 2. gardnerella vaginalis was the most frequently isolated organism. ureaplasma urealyticum was isolated from 14(48%) of 29 women in group 1 and from two (12.5%) of 16 women in gro ...	1981	7276624
current therapy of vulvovaginitis.	trichomoniasis is reliably treated with a single 2-g dose of metronidazole; however, with this regimen simultaneous treatment of sexual partners is particularly important. trichomoniasis in pregnant women, who should not receive metronidazole, might be treated initially with clotrimazole vaginal suppositories, which appear to cure about 50% of cases. topical antifungal agents of the imidazole class are superior to polyenes in treating vulvovaginal candidiasis. boric acid powder applied intravagi ...	1981	7330756
haemophilus vaginalis (corynebacterium vaginale, gardnerella vaginalis) in a family planning clinic population.	vaginal specimens were obtained at 902 attendances from 522 women requiring vaginal examination at a family planning clinic. haemophilus vaginalis was found in 8% of specimens either by culture or by at least two out of three microscopical tests; lactobacilli were seldom found in the presence of the organism. increased signs and symptoms, especially an offensive odour, were found only when h vaginalis and staphylococcus were isolated together. the organism was found less often in patients using ...	1981	6970605
gardnerella vaginalis perinephric abscess in a transplanted kidney.		1981	7010159
[possibilities for cultural diagnosis of vaginal flora (author's transl)].	reported in this paper are some possible approaches to culturing of vaginal flora. plastic slides and various selective culturing media are described. the results so far achieved are likely to suggest that the above approach is applicable in practice.	1981	7015753
[characterisation of corynebacterium vaginale by the fluorescent antibody technic (author's transl)].	when using the serum of rabbits immunized against the reference vaginal strain 594 of gardner and dukes, the authors tried to find an antigenic identity between this strain and the usual strains that can ordinarily be detected in vaginal samples. the immunizing process that has been used is indirect immunofluorescence. through these studies, it is possible to conclude that, besides usual strains identical to the reference strain, some specific strains can be detected that have the same microscop ...	1981	7018327
ambulatory management of vaginal infections, infestations, and anomalies.		1981	7022512
rapid identification of corynebacterium vaginale in non-purulent vaginitis.	a simple set of tests is proposed to give excellent probability for the identification of corynebacterium vaginale from clinical material. using these tests, 380 c vaginale were isolated from genital tract specimens from 1402 patients. of these isolates 70 were from symptomatic patients. these 70 isolates were subjected to a further set of tests to confirm their identity. the advantage of these primary tests is that they can be completed on the day of isolation of the organism. of these 70 isola ...	1981	7024317
ureaplasma urealyticum in the upper urinary tracts of renal allograft recipients.	urine samples from 123 renal transplant recipients were cultured for the presence of ureaplasma urealyticum and other fastidious microorganisms. ureaplasmas were recovered alone or in association with other microbial species from the bladder urine of 13 (11%) of the 123 patients, and evidence of involvement of the upper urinary tract was present in nine patients. colonization of the upper urinary tract by u. urealyticum was not associated with a decline in function of the grafted kidney and was ...	1981	7024429
vaginitis associated with vaginal malodour.	in two general practices in perth, western australia, the most common microbiological causes of vaginal discomfort in 368 patients were candida albicans. gardnerella (haemophilus) vaginalis, trichomonas vaginalis and bacteroides fragilis. amongst patients with abnormal vaginal odour, with or without vaginitis, the most common cause of odour was g. vaginalis. the writers advocate that heavy growths of group b streptococci, escherichia coli, and enterococci should be considered to be the possible ...	1981	7029228
nonspecific vaginosis.	nonspecific vaginosis (nsv) is a very common clinical syndrome with characteristic clinical, biochemical, and microbiologic features. there is a thin, malodorous homogeneous, grey, nonpurulent vaginal discharge. the discharge usually has a ph greater than 4.5, contains "clue cells" on wet mount examination, and produces a "fishy" odor when mixed with 10% potassium hydroxide. the discharge contains an increased concentration of at least seven amines which are presumably produced by bacterial deca ...	1981	6941446
sexually transmitted conditions among women college students.	we studied 500 unselected young women who consulted a gynecologist in a student health service. most participants were symptom-free and had normal physical examinations. few sexually transmitted infections were encountered. neisseria gonorrhoeae was recovered from two and trichomonas vaginalis was obtained from 14 of 500 women. chlamydia trachomatis was recovered from 20 (4.6%) of 439 participants. genital warts, genital herpes, and molluscum contagiosum, respectively, were noted in seven, four, ...	1981	6779634
adherence of bacteria to vaginal epithelial cells at various times in the menstrual cycle.	adherence of vaginal isolates of escherichia coli, lactobacillus species, group b streptococci, gardnerella vaginalis and neisseria gonorrhoeae to exfoliated vaginal epithelial cells was studied in 10 healthy, sexually active medical students. studies were done pre- and postmenstrually and at midcycle for two consecutive menstrual cycles. the mean number of adherent bacteria per vaginal epithelial cell (range) was 3.4 (0 to 14) for e. coli, 60.5 (12 to 152) for lactobacillus species, 54.8 (21 to ...	1981	6783548
vaginitis revisited.		1981	6791731
vaginitis revisited.		1981	6794790
vaginitis revisited.		1981	6794847
the effect of a contraceptive vaginal ring and oral contraceptives on the vaginal flora.	premenopausal women seeking a steroid contraceptive method were allowed to choose between a contraceptive vaginal ring (cvr) containing levonorgestrel and estradiol used in a 3-week in, 1-week out regimen (n=20) and an oral contraceptive (oc) containing levonorgestrel and ethinyl estradiol in a 28-day regimen (n = 10). cultures from the posterior vaginal fornix were obtained before therapy in both groups and monthly for 6 months for the cvr group and after 1, 3, and 6 months for the oc group. th ...	1981	6797788
treatment of hemophilus vaginalis vaginitis.	four antimicrobial agents (triple sulfa cream, doxycycline, ampicillin, and metronidazole) were studied by double-blind techniques to determine their effectiveness in the treatment of hemophilus vaginalis vaginitis, documented by vaginal culture in 96 patients. cure was confirmed by negative vaginal cultures 7 weeks after the start of therapy. metronidazole proved to be effective in 20 of 22 couples (90.9%) treated. sulfa cream, doxycycline, and ampicillin were effective in 47.8 to 63.6% of pati ...	1981	6972018
scanning electron microscopic examination of bacteroides fragilis and gardnerella vaginalis after exposure to concentration gradients of metronidazole and tinidazole.	agar diffusion tests with metronidazole and tinidazole were performed with one strain each of bacteroides fragilis and gardnerella vaginalis (haemophilus vaginalis, corynebacterium vaginalis). their cell morphology was studied 'in situ' on agar surfaces by means of scanning electron microscopy (sem). a sharp growth end-point was found for b. fragilis, whereas with g. vaginalis there was a gradual decrease in the number and size of the colonies close to the agar well. the sem study also revealed ...	1981	6972572
in vitro susceptibility of gardnerella vaginalis to high concentrations of sulfonamide compounds.	the excipients of triple sulfa vaginal tablets were ineffective against gardnerella vaginalis in vitro. the three sulfonamides, however, were inhibitory, and minimal inhibitory concentration tests showed many strains to be susceptible to 25,000 mug of sulfacetamide per ml.	1981	6972733
clinical features of vaginal infections.		1981	6973061
non-specific vaginitis: its diagnosis and treatment.		1981	6973563
rapid presumptive identification of gardnerella vaginalis (haemophilus vaginalis) from human blood agar media.	presumptive identification of gardnerella vaginalis from 48-h human blood agar cultures by using a gram stain, hemolysis, and colonial morphology was highly accurate.	1981	6973571
the role of gardnerella vaginalis in nonspecific vaginitis.		1981	6975685
gardnerella vaginalis vaginitis.		1981	6976122
haemophilus vaginalis vaginitis (corynebacterium vaginale).		1981	6976323
controversies in the management of vaginitis.		1981	6976584
metronidazole metabolite and gardnerella vaginalis (corynebacterium vaginale)		1981	6112482
gardnerella vaginalis and prostatitis.		1981	6116022
haemophilus vaginalis infection. diagnosis and treatment.	some 4,263 women from special, family planning and gynecologic clinics were screened at random for the presence of h. vaginalis (c. vaginale) infection. twenty-four percent of the women from the special clinics, 6% from the family planning and 4% from the gynecology clinics were culture positive although microscopic findings were somewhat higher than this. of 582 women attending special clinics who were infected solely with h. vaginalis, only 261 complained of having an offensive discharge. two ...	1980	6153721
corynebacterium vaginale and vaginitis: a controlled trial of treatment.	in a study of the diagnosis and treatment of corynebacterium vaginale (haemophilus vaginalis) vaginitis in 30 patients, clinical and microscopical findings were compared with laboratory cultures. the study also included a double-blind randomised trial of treatment regimens including placebo therapy. laboratory cultures of c. vaginale corresponded well with clinical findings, and we suggest that c. vaginale vaginitis can be reliably diagnosed with clinical and microscopical findings. tetracycline ...	1980	6102231
metronidazole for non-specific vaginitis.		1980	6103353
metronidazole for non-specific vaginitis.		1980	6103355
tetracycline and corynebacterium vaginale.		1980	6103471
metronidazole for corynebacterium vaginale vaginitis.		1980	6105324
hemophilus vaginalis bacteremia.	during 1975--77 hemophilus vaginalis bacteremia occurred post partum in eight previously healthy women. seven had been admitted for delivery at term and one because of threatened abortion. six underwent cesarean section. post-partum pyrexia and neutrophilia were the main features. all the patients recovered uneventfully while receiving antibiotics. h. vaginalis is an infrequent agent of bacteremia; it affects predominantly women after obstetric trauma.	1980	6966179
anaerobic bacteria in nonspecific vaginitis.	to study the cause of nonspecific vaginitis, we analyzed vaginal fluid from normal women and from 53 women with nonspecific vaginitis, using quantitative anaerobic cultures and gas-liquid chromatography for short-chained organic-acid metabolites of the microbial flora. in normal vaginal fluid, lactate was the predominant acid, and the predominant organisms were lactobacillus and streptococcus species (lactate producers). in nonspecific vaginitis, lactate was decreased, whereas succinate, acetate ...	1980	6967562
the origin and diagnosis of "nonspecific vaginitis".		1980	6967563
metronidazole in treatment against haemophilus vaginalis (corynebacterium vaginale).	the rate of bactericidal activity and inactivation of metronidazole was studied in time-kill curves with haemophilus vaginalis (corynebacterium vaginale). the minimum inhibitory concentrations of metronidazole for the eight strains tested ranged from 4 to 16 micrograms/ml. at a concentration of 20 micrograms/ml, metronidazole demonstrated a slow cidal effect against exponential-phase organisms, requiring 24 to 48 h for completion. inactivation of metronidazole during the time-kill curve was quit ...	1980	6968175
hemophilus vaginalis vaginitis in children--two cases.		1980	6969784
vaginal discharge in the black pregnant patient: an evaluation of the relationship between symptomatology and diagnosis.	three hundred and thirty pregnant black antenatal patients with symptomatic vaginal discharge were assessed. there appeared to be no correlation between the symptoms (pruritus, burning, amount of discharge and appearance) and the expected diagnosis. the common organisms trichomonas vaginalis, haemophilus vaginalis, candida albicans and neisseria gonorrhoeae were evaluated. it was also noted that a large number of patients (54%) had negative cultures although their complaints were similar to thos ...	1980	6773152
inhibition of some normal and pathogenic vaginal bacteria by oral and vaginal streptococci.	hemolytic and nonhemolytic strains of streptococcus faecalis, together with some strains of oral and vaginal alpha-hemolytic streptococci, produced one or more factors that inhibited the growth of gardnerella vaginalis, neisseria gonorrhoeae, and a variety of other vaginal bacteria. some streptococci were inhibitory to indicator organisms only in the presence of catalase, whereas catalase either enhanced or prevented inhibitory action for still other streptococci. the inhibitors produced by cert ...	1980	6777883
relative susceptibilities of gardnerella vaginalis (haemophilus vaginalis), neisseria gonorrhoeae, and bacteroides fragilis to metronidazole and its two major metabolites.	the susceptibilities of strains of gardnerella vaginalis (haemophilus vaginalis), neisseria gonorrhoeae, and bacteroides fragilis to metronidazole and its principal oxidative metabolites (1-[2-hydroxyethyl]-2-hydroxymethyl-5-nitroimidazole) ("hydroxy" metabolite) and 1-acetic acid-2-methyl-5-nitroimidazole ("acid" metabolite), were compared by determinations of the minimal inhibitory concentrations (mics) of these compounds. against ten strains of g. vaginalis, the hydroxy metabolite was the mos ...	1980	6779387
a taxonomic study of gardnerella vaginalis (haemophilus vaginalis) gardner and dukes 1955.	fifty-five strains received as haemophilus vaginalis or as catalase-negative coryneform bacteria from the vagina together with 61 marker cultures were subjected to numerical phenetic analyses using 149 unit characters. the data were examined using the simple matching (ssm), jaccard (sj) and pattern (dp) coefficients and clustering was achieved using the average linkage algorithm. cluster composition was not markedly affected by the coefficient used or by test error, estimated at 6 . 5%. the h. v ...	1980	6971916
[on the taxonomy of actinobacillus, haemophilus, and pasteurella: dna base composition, respiratory quinones, and biochemical reactions of representative collection cultures (author's transl)].	in a comparative study, 63 collection cultures representing 38 nomenspecies of, or assigned to, the genera actinobacillus, haemophilus, or pasteurella were characterized by phenotypical features and deoxyribonucleic acid base composition. the latter was calculated from the thermal denaturation point. biochemical reactions were tested in differential media commonly used for enterobacteriaceae, and two test procedures were compared: (i) pure cultures with haematin and nicotine adenine dinucleotide ...	1980	7424243
cellular fatty acid composition of haemophilus species, pasteurella multocida, actinobacillus actinomycetemcomitans and haemophilus vaginalis (corynebacterium vaginale).	the fatty acid composition of 35 haemophilus influenzae strains was found to be grossly similar and characterized by relatively large amounts of 14:0, 3-oh-14:0, 16:1 and 16:0. the three c18 fatty acids 18:2, 18:1 and 18:0 were also present, but in much lower concentrations. this general pattern was also found for most of the other species of haemophilus examined (h. aegyptius, h. aphrophilus, h. canis, h. gallinarum, h. haemolyticus, and h. parainfluenzae). small but distinct quantitative discr ...	1980	6990689
haemophilus vaginalis vaginitis after twenty-five years.	this paper provides an abbreviated review of developments related to haemophilus vaginalis vaginitis since its original description a quarter of a century ago. my intervening years of interest and research in the field of vulvovaginal infections have served to further confirm the originally published concepts regarding this highly prevalent, precisely defined, readily recognizable, and aesthetically objectionable vaginal disease. an occasional investigator still questions the pathogenicity of th ...	1980	6990764
treatment of vaginitis.	the physiology and flora of the normal vagina and the more common causes and associated treatments of vaginitis are reviewed. vaginitis encompasses a group of diseases causing inflammatory changes in the vagina and vulva. treatment of the various vaginitides requires accurate diagnosis, which is hampered by difficulties in culturing pathogens and in resolving the pathogenicity of various organisms. the ability of the body to withstand vaginitis is affected by physiologic changes within the vagin ...	1980	6996478