Publications

[prevalence of mycoplasma hominis and ureaplasma urealyticum in patients with impaired fertility].		1986	3964000
[incidence of mycoplasma hominis in women using an iud].		1986	3714257
vaginal colonization with mycoplasma hominis and ureaplasma urealyticum.	vaginal cultures obtained from unselected young women who consulted the gynecologist in a student health service were examined for ureaplasma urealyticum and mycoplasma hominis. each participant completed a confidential questionnaire. multiple logistic regression analysis was used to determine which variables, of a large number ascertained, were associated with mycoplasmal colonization. u. urealyticum was isolated from 273 (56.8%) of 481 participants. the following variables were significantly p ...	1986	3715677
[incidence of ureaplasma urealyticum and mycoplasma hominis in persons examined for sterility].		1986	3719732
prevalence of chlamydia trachomatis and other micro-organisms in women seeking abortions in pittsburgh, pennsylvania, united states of america.	the prevalence of chlamydia trachomatis, ureaplasma urealyticum, mycoplasma hominis, group b streptococcus, herpes simplex virus, and neisseria gonorrhoeae from cervical cultures obtained from 210 women seeking abortion in pittsburgh, pennsylvania, united states of america was 9.3%, 72.9%, 25.2%, 4.3%, 0.9%, and 0.9% respectively. cultures from 40/203 (19.7%) patients failed to produce any of these organisms. c trachomatis isolation was not associated with age, race, marital status, average fami ...	1986	3721515
hormonal status and mycoplasma colonization in the female genital tract.	three hundred seventy-four cervical or vaginal specimens from patients with various hormonal states were cultured for ureaplasma urealyticum and mycoplasma hominis. significantly, low recovery rates of u urealyticum were obtained in the prepuberty (5%), puerperium (24%), and postmenopause (25%) groups, whereas pregnant women showed the highest incidence of u urealyticum (82%). the recovery rate of u urealyticum from neonates was 42%. the incidence of u urealyticum in sexually inactive females wa ...	1986	3737042
genital mycoplasma colonization in neonatal girls.	specimens obtained from the genital tract of 90 pairs of mothers and their female infants were cultured for ureaplasma urealyticum (ureaplasma) and mycoplasma hominis (m.hominis). ureaplasma and m.hominis were isolated from 80% and 17% of pregnant women, and 41% and 4.4% of female infants, respectively. fifty nine per cent of infants were positive for ureaplasma when they were borne per vaginam by ureaplasma-positive mothers. however, ureaplasma was not isolated from any of 11 infants delivered ...	1986	3739634
clinical and microbiological investigation of women with acute salpingitis and their consorts.	to determine the microbiological causes of pelvic inflammatory disease, 43 women with acute salpingitis (as) and 160 controls were studied. amongst as women there were significantly higher endocervical isolation rates of neisseria gonorrhoeae (54% vs 6%), chlamydia trachomatis (40% vs 13%), mycoplasma hominis (60% vs 19%), enterobacteria (26% vs 11%) and anaerobic bacteria (58% vs 29%). a polymicrobial pathogenic endocervical flora was present in both gonococcal and non-gonococcal as. laparoscop ...	1986	3741814
treatment of sexually transmitted diseases.	this paper outline the treatments of choice for sexually transmitted infections. current treatment recommendations for gonorrhea reflect the emergence of tetracycline-resistant neisseria gonorrhoeae and the increasing prevalence of penicillinase-producing strains that are resistant to penicillin. a single dose of amoxicillin is highly effectice against urethral or cervical gonorrhea caused by penicillin-susceptible strains; also effective is a new agent, ceftriaxone. however, neither of these ...	1986	3754031
antimicrobial susceptibility testing of mycoplasma hominis.		1986	3759152
[the role of intrauterine contraceptive devices in the development of inflammatory processes in the small pelvis].	the incidence of pelvic inflammatory disease (pid) attributable to iud use has been increasing, especially after the removal of the dalkon shield from the market, but this relationship has not been settled conclusively. in recent decades pid included a variety of infections, but lately the definition of pid has meant acute ascending infections of the female genital tract. its most common risk factors include promiscuity of iud use, although this can be reduced to one fourth by regular checkups ...	1986	3763205
role of genital mycoplasmas in young infants with suspected sepsis.	to establish the prevalence of mycoplasma hominis and ureaplasma urealyticum in infants up to 3 months of age with suspected sepsis, blood, cerebrospinal fluid, and urine specimens from 203 patients with clinical signs and symptoms of sepsis were cultured for mycoplasma in addition to routine bacterial cultures. proved bacterial infections were identified in 24 patients, four of whom had bacteremia. m. hominis and u. urealyticum were not isolated from any of the 191 blood and 199 csf specimens t ...	1986	3783341
chorionic mycoplasmas and prematurity.	in this study, recovery of ureaplasma urealyticum and mycoplasma hominis from the freshly exposed chorion following delivery was related to labor length but not to the interval between membrane rupture and delivery, to birth weight or to gestational age.	1986	3795198
ureaplasma urealyticum in the immunocompromised host.	the lack of antibody in hypogammaglobulinemic patients probably results in failure of mycoplasmas to be "neutralized" and accounts for the diminished ability of the patients to cope with these organisms escaping hematogenously from the respiratory and urogenital tracts. furthermore ureaplasma urealyticum and other mycoplasmas are ingested by neutrophils in the absence of opsonins, indicated by the fact that they are able to trigger the release of chemiluminescence from these cells; ureaplasmas a ...	1986	3797323
a survey of mycoplasma detection in veterinary vaccines.	nine live virus veterinary vaccines from six sources were found to be contaminated with mycoplasma. the vaccines were for use in canine, feline and avian species, and 53 batches of the products were at fault. the isolates were identified as mycoplasma hominis, m. arginini, m. orale, m. hyorhinis and m. gallinarum. investigation of the contamination rate of other batches or other products from the same source in some cases helped to determine the source of infection. mycoplasma contaminants can b ...	1986	3799018
arginine deiminase of mycoplasma hominis: cytoplasmic and membrane-associated forms.	membrane and cytoplasmic fractions of mycoplasma hominis inhibited the multiplication of this mycoplasma. arginine deiminase (ec 3.5.3.6), isolated from both fractions, reproduced the inhibition. the purified cytoplasmic deiminase had a subunit mr of 49,000, a specific activity of 53 units (mg protein)-1 and an a280/a260 ratio of 1.76. the membrane-associated enzyme had an identical mr but lower values for specific activity [39 units (mg protein)-1] and the a280/a260 ratio (1.46). in experiments ...	1986	3806049
[in vitro activity of nitroxoline on urogenital mycoplasmas].	the product nitroxoline was studied in vitro for its activity towards ureaplasma urealyticum and mycoplasma hominis. in view of the low mic values obtained, it seems nitroxoline could be used in the treatment of urinary infections. it is bactericidal, and should not produce resistant strains.	1986	3543811
epidemiologic and clinical characteristics of pelvic inflammatory disease associated with mycoplasma hominis, chlamydia trachomatis, and neisseria gonorrhoeae.	we studied selected epidemiologic, clinical, serologic, and microbiologic findings and their interrelationships among 57 women with acute pelvic inflammatory disease (pid). cervical cultures positive for neisseria gonorrhoeae alone and for both n. gonorrhoeae and chlamydia trachomatis were associated with young age, nulliparity, and use of birth-control pills. positive serologic findings for c. trachomatis were associated with the isolation of c. trachomatis and/or n. gonorrhoeae from the cervix ...	1986	3082018
sexually transmissible infectious agents in sexually active and virginal asymptomatic adolescent girls.	sixty-eight sexually active and 52 virginal adolescent girls were evaluated for six sexually transmissible infectious agents: gardnerella vaginalis, ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis, trichomonas vaginalis, and neisseria gonorrhoeae. there were significant differences between sexually active and virginal girls with respect to the prevalence of isolation of u urealyticum (75% v 33%, p less than .005), m hominis (27% v 10%, p less than .05), and c trachomatis (19% v ...	1986	3083395
in vitro activity of the two new 4-quinolones a56619 and a56620 against neisseria gonorrhoeae, chlamydia trachomatis, mycoplasma hominis, ureaplasma urealyticum and gardnerella vaginalis.	the in vitro activity of tetracycline, ciprofloxacin and two recently developed 1-aryl-fluoroquinolones, a56610 and a56620, was tested against 65 beta-lactamase-negative and 35 beta-lactamase-positive neisseria gonorrhoeae strains, 12 chlamydia trachomatis, 50 mycoplasma hominis, 28 ureaplasma urealyticum and 50 gardnerella vaginalis strains. in the case of chlamydia trachomatis and mycoplasma hominis both the mic and the mbc were determined. the mic90 of ciprofloxacin for neisseria gonorrhoeae ...	1986	3096726
high-level tetracycline resistance in neisseria gonorrhoeae is result of acquisition of streptococcal tetm determinant.	recently, strains of neisseria gonorrhoeae have been isolated which are highly resistant to tetracycline (mics of 16 to 64 micrograms/ml). this resistance was due to the acquisition of the resistance determinant tetm, a transposon-borne determinant initially found in the genus streptococcus and more recently in mycoplasma hominis, ureaplasma urealyticum, and gardnerella vaginalis. in n. gonorrhoeae, the tetm determinant was located on a 25.2-megadalton plasmid. this plasmid arose from the insert ...	1986	3099640
infection with chlamydia trachomatis in female college students.	chlamydia trachomatis was isolated from genital specimens from 21 (4.9%) of 431 female college students. antibody to c. trachomatis was found in the genital secretions of 52 (11.9%) of 437 women. multiple logistic regression analysis showed race, number of sexual partners, and use of barrier methods of contraception to be predictive of infection with c. trachomatis. logistic regression analysis found race, number of sexual partners, use of barrier methods of contraception, and presence of cervic ...	1985	3964985
the effect of mycoplasma hominis and ureaplasma urealyticum on hamster egg in vitro penetration by human spermatozoa.	the effects of some genital mycoplasmas on the in vitro penetration of human spermatozoa into the master egg were studied. ureaplasma urealyticum serotypes 4, 8, and 6 showed high interfering activity: 6.3% (p less than 0.01), 12.3%, and 14.5%, respectively, against the 55.6% penetration rate of untreated sperm. neither a cytotoxic effect of mycoplasmas on gametes nor a masking of the binding sites on the egg surface were demonstrated. in experiments carried out with u. urealyticum serotype 4, t ...	1985	3965307
detection of mycoplasma hominis septicemia by radiometric blood culture.	the ease with which mycoplasma hominis can be recovered and the frequency of its occurrence in septicemia may not be fully appreciated. we detected the growth of m. hominis radiometrically with an automated blood culture instrument. the organism grew in both aerobic and anaerobic culture media, but the cultures were not visibly positive. it was necessary to stain the cultures with acridine orange to visualize m. hominis and to subculture them on columbia base sheep blood agar to confirm the posi ...	1985	3980685
[mycoplasma hominis salpingitis. a serological study].		1985	3992557
importance of mycoplasma hominis in acute salpingitis assessed by culture and serological tests.	in 95 women with a provisional diagnosis of pelvic inflammatory disease, a final diagnosis of acute salpingitis was confirmed by laparoscopy in 46 and 10 had strong clinical evidence of acute salpingitis. the findings in the remaining 39 patients without signs of acute salpingitis by laparoscopy were used as a standard of reference. criteria for the diagnosis of possible mycoplasmal salpingitis were tentatively defined as the isolation of mycoplasma hominis from the cervix together with positive ...	1985	4007861
neonatal mycoplasmaemia: mycoplasma hominis as a significant cause of disease?	a full-term baby boy had respiratory distress, fever and pneumonia within 20 h of birth. isolation of mycoplasma hominis from blood taken after 20 h and 11 days was accompanied by an antibody response. although chlamydial igm antibody was detected, chlamydial infection probably did not cause the pneumonia. penicillin was ineffective but treatment with gentamicin, and particularly tetracycline, was associated with slow improvement. mycoplasma hominis should be considered as a cause of respiratory ...	1985	4008964
nucleic acid relationships among the anaerobic mycoplasmas.	the genetic relatedness between twelve selected strains among four distinct serovars of anaerobic mycoplasmas was studied using [3h]dna-dna hybridization, and the results were compared with data obtained from biochemical and serological tests. radiolabelled dna probes were prepared from five strains representing four serovars. based on the homology results, the anaerobic mycoplasmas can be divided into five distinct groups representing five distinct species and two distinct genera. there are two ...	1985	4020344
[incidence of mycoplasma hominis in men examined for infertility].		1985	4034195
urethral isolation of the genital mycoplasmas and chlamydia trachomatis in women with chronic urologic complaints.	eighty-six abacteriuric women with chronic urologic complaints were studied to determine the relationship of chlamydia trachomatis, mycoplasma hominis, and ureaplasma urealyticum to their symptoms or diagnoses. all patients had urethral scrape specimens for isolation of the three organisms as well as a detailed urologic history and urodynamic evaluation. thirty-three of 86 patients (38%) had positive urethral ureaplasma cultures; seven had concurrent m. hominis isolation. no patient had m. homin ...	1985	4039533
prevalence of chlamydia trachomatis and genital mycoplasmas in asymptomatic women.	to establish the prevalence of chlamydia trachomatis, mycoplasma hominis and ureaplasma urealyticum in women attending a family planning and a prenatal clinic in halifax, cervical swabs were obtained at the time of the first visit from 491 women who had no symptoms of genital infection. among the women attending the family planning clinic m. hominis occurred in combination with c. trachomatis more frequently than expected (p less than 0.05). it occurred in the absence of u. urealyticum in only a ...	1985	4039970
microbiological and serological study of non-gonococcal urethritis with special reference to mycoplasma genitalium.	twenty-two men with non-gonococcal urethritis (ngu), 19 with gonorrhoea, and 22 without urethritis were examined for various micro-organisms. chlamydia trachomatis was isolated from the urethra of 45% of men with ngu, 21% of those with gonorrhoea, but from none without urethritis. ureaplasma urealyticum but not mycoplasma hominis was recovered from a larger proportion of men with ngu than from those in the other groups. m genitalium was isolated presumptively from 32% of men with ngu, 12% of tho ...	1985	4043971
concrement formation in the urinary bladder in rats inoculated with ureaplasma urealyticum.	to study the concrement-forming ability of ureaplasma urealyticum in the urinary tract, viable and heat-killed ureaplasmas as well as urease and non-urease-producing bacteria were inoculated into the bladder in rats. viable ureaplasmas, in contrast to heat-killed, caused the formation of bladder stones with a frequency corresponding to urease-producing bacteria (proteus mirabilis). it was not possible to reculture the inoculated ureaplasmas from the urinary tract. non-urease producing microorgan ...	1985	4049607
[mycoplasma hominis as a possible etiologic factor in diseases of the female genitalia].		1985	4063861
the photosensitizing activity of haematoporphyrin on mollicutes.	the photosensitizing activity of haematoporphyrin (hp) on mycoplasma hominis and acholeplasma laidlawii was studied as a function of the phase of growth and the amount of sterols in the cell membrane. less hp was bound to cells when the membrane had a high sterol content. both strains in the exponential but not in the stationary phase of growth were sensitive to hp treatment (above 1 microgram ml-1) in the dark. visible light irradiation of hp-loaded cells caused in all cases a decrease of cell ...	1985	4067577
ureaplasma urealyticum causing persistent urethritis in a patient with hypogammaglobulinaemia.	ureaplasma urealyticum organisms (ureaplasmas) were isolated in large numbers (up to 10(8) colour changing units (ccu)/ml) over a period of four years from the urethra of a man with hypogammaglobulinaemia and non-gonococcal urethritis. elimination of mycoplasma hominis by antibiotic treatment early in the course of the urethritis did not diminish the severity of his condition, which indicated that this mycoplasma was not a cause. courses of treatment with tetracyclines, spectinomycin, erythromyc ...	1985	4086030
[role of mycoplasma hominis and ureaplasma urealyticum in the etiology of various diseases].		1985	3835596
prevalence of low genital tract infectious agents in young israeli women.	low genital tract infectious agents were examined 411 times in 386 young women. each examination included anamnesis, physical examination and broad-spectrum microbiologic analysis for the detection of: ureaplasma urealyticum, chlamydia trachomatis, trichomonas vaginalis, candida species, mycoplasma hominis, streptococcus beta hemolyticus group b, hemophilus vaginalis, neisseria gonorrhoeae and syphilis serology. three hundred and six patients were symptomatic for low genital tract infection and ...	1985	3873446
serological evidence that chlamydiae and mycoplasmas are involved in infertility of women.	women with a history of infertility for 2 or more years were examined by hysterosalpingography (hsg) and antibodies against chlamydia trachomatis, mycoplasma hominis and m. genitalium were measured by a microimmunofluorescence technique in sera obtained immediately before hsg. of 45 women with abnormal hsg findings, 15 (33%) had antibodies to c. trachomatis and 16 (35.5%) to m. hominis. in contrast, of 61 women with normal hsg findings, only 8 (13%) and 7 (11.5%) had antibodies to these micro-or ...	1985	3881583
proteolytic activity of mycoplasmas and ureaplasmas isolated freshly from human saliva.	mycoplasma and ureaplasma strains freshly isolated from human saliva were examined for proteolytic activity. all the strains tested (101 strains of mycoplasma salivarium, 97 strains of mycoplasma orale, and 3 strains each of mycoplasma hominis and ureaplasma urealyticum) decomposed horse serum proteins, bovine albumin, and casein. ten of the m. salivarium and 8 of the m. orale strains were tested for aminopeptidase activity as well, using l-leucine-p-nitroanilide as a substrate, and were shown t ...	1985	3881657
chlamydia trachomatis, mycoplasma hominis, and ureaplasma urealyticum infections of infants.		1985	3881828
chlamydia, mycoplasmas, ureaplasmas, and yeasts in the lower genital tract of females. comparison between a group attending a venereal disease clinic and a control group.	162 women were investigated. group i consisted of 85 women, who were partners to men with non-gonococcal urethritis (ngu) or presented macroscopic signs of cervicitis; patients who had harbored neisseria gonorrhoeae were excluded from the study. group ii was a control group of 77 women without any complaints from the urogenital tract and with normal findings at pelvic examination. all the women were tested for infection with chlamydia trachomatis, mycoplasma hominis, ureaplasma urealyticum, and ...	1985	3885669
invasiveness of salmonella typhimurium in hep-2 cell cultures pre-infected with mycoplasma hominis and mycoplasma orale.	the influence of mycoplasma infection on the in vitro invasiveness of s. typhimurium in hep-2 cell cultures has been tested. two strains of arginine-utilizing mycoplasma species mycoplasma hominis and m. orale both seemed to inhibit the bacterial in vitro invasiveness. both the ratio of infected cells and the number of intracellular bacteria per cell were reduced in the mycoplasma-infected cultures.	1985	3885679
women at risk for gonorrhea: comparison of rosaramicin and ampicillin plus probenecid in the eradication of neisseria gonorrhoeae, chlamydia trachomatis and genital mycoplasmas.	rosaramicin is a macrolide antibiotic with activity against neisseria gonorrhoeae, chlamydia trachomatis, and the genital mycoplasmas ureaplasma urealyticum and mycoplasma hominis. its efficacy in the treatment of genital infections was evaluated and compared with that of single-dose ampicillin plus probenecid in women with known, or suspected, uncomplicated gonococcal infection. isolation rates for n. gonorrhoeae, c. trachomatis, u. urealyticum, and m. hominis were 72%, 44%, 95%, and 65%, respe ...	1985	3890223
prophylaxis with lymecycline in induced first-trimester abortion: a clinical, controlled trial assessing the role of chlamydia trachomatis and mycoplasma hominis.	a clinical, controlled trial was performed to study the effect of prophylaxis with lymecycline and the role of chlamydia trachomatis and mycoplasma hominis in postabortal genital infection. of 532 women who were to undergo first-trimester abortion, 269 were randomized to treatment with oral lymecycline (300 mg bid) starting 2 days before the abortion and continuing for a total of 7 days, and 263 were randomized to placebo treatment. the rate of postabortal infection was 9.3% in the antibiotic gr ...	1985	3890229
[antibiotic sensitivity of mycoplasma pathogenic for man].	human pathogen mycoplasmas (mycoplasma pneumoniae, mycoplasma hominis, ureaplasma urealyticum) are intrinsically resistant to antibiotics which inhibit the cell wall biosynthesis (beta-lactams, vancomycin, bacitracin), to polymyxins, rifamycins, sulfonamides, trimethoprim, 5-nitroimidazoles, nitrofurans and to presently available quinolones. these three species are moderately susceptible to aminoglycosides, susceptible to chloramphenicol and highly susceptible to tetracyclines. m. pneumoniae is ...	1985	3892448
[genital mycoplasma infections].	clinical and experimental investigations on the significance of mycoplasma hominis and ureaplasma urealyticum have revealed different and contradictory results. both germs are frequently discovered in young, sexually active persons. ureaplasma urealyticum might be the cause of some cases of non-gonococcal urethritis. m. hominis seems to be one causative agent of endometritis, salpingitis, parametritis and septicaemia after birth; we do not know yet, however, how often this may be the case. m. ho ...	1985	3904251
the relation between vaginal ph and the microbiological status in vaginitis.	the vaginal ph, microbial flora and presence of clue cells were investigated in 89 women who were seen at a sexually transmitted diseases clinic with a vaginal discharge or because they were contacts of men with gonococcal or non-gonococcal urethritis or because they were seeking a routine examination. none of the women had received antibiotics for at least 4 weeks before examination. a clinically normal vaginal secretion was found in 21 (55%) of 38 women who had a vaginal ph of 5.0-5.5, while s ...	1985	3910080
antibodies to microbial, leukocyte and organ antigens.	hemagglutinating antibodies to mycoplasma hominis were present in 30 of 83 infertile, 15 of 40 pregnant and 5 of 20 post-partum females and 20 of 82 infertile males in contrast to only 2 of 21 fertile females and 5 of 25 fertile males. their presence correlated with sperm antibody detection by tat in lab. 4, the immunobead-binding assay of lab. 1 and the sit of lab. 11, but not with other sperm antibody assays. immunofluorescent antibodies to chlamydia trachomatis, on the other hand, did not cor ...	1985	3914551
pelvic inflammatory disease, intrauterine contraception, and the conduct of epidemiologic studies.	pelvic inflammatory disease (pid) has been described in the medical literature for more than a century as a specific entity. neisseria gonorrhoeae, chlamydia trachomatis, and mycoplasma hominis, along with bacteroides fragilis and other anaerobic bacteria, have been most frequently associated with pid. factors affecting the occurrence of pid have been extensively studied during the past two decades and include number of sexual partners, age, race, socioeconomic status, education, and contracepti ...	1985	3916040
prevalence and manifestations of endometritis among women with cervicitis.	thirty-five women referred from a clinic treating sexually transmitted diseases, because of suspected cervicitis, were studied for the presence of endometritis by transcervical endometrial biopsies and cervical and endometrial cultures. fourteen (40%) of the patients had histologic evidence of endometritis. findings that significantly correlated with endometritis included a history of intermenstrual vaginal bleeding, the presence of chlamydia trachomatis, neisseria gonorrhoeae, or streptococcus ...	1985	3923837
prevalence of antibodies to chlamydia trachomatis, neisseria gonorrhoeae, and mycoplasma hominis in infertile women.	a total of 57 infertile women, who had been referred for in vitro fertilisation or for diagnostic laparoscopy, were tested for the presence of antibodies to chlamydia trachomatis, neisseria gonorrhoeae, and mycoplasma hominis. four were excluded from the study. of the remaining 53, 33 had laparoscopically obvious tubal disorders, such as adhesions, distal occlusions and strictures, and 20 did not. antibodies to c trachomatis were found in 7/33 (21.2%) v 0/20, antibodies to n gonorrhoeae in 20/38 ...	1985	3924815
effects of mycoplasma hominis on in-vitro studies of neisseria gonorrhoeae.	this study examined the effects mycoplasma hominis might have on neisseria gonorrhoeae. two auxotype standard strains of n. gonorrhoeae were found by culture and by light, fluorescence, and electron microscopy to be contaminated with m. hominis. in the presence of m. hominis, these strains of n. gonorrhoeae were typed as prototrophic. removal of the mycoplasmas by passage of the n. gonorrhoeae on serum-free medium resulted in a second change in growth requirements rather than a reversion to the ...	1985	3929403
[comparative activity of minocycline and doxycycline on mycoplasmas pathogenic for man].	susceptibility of mycoplasma pneumoniae (10 strains), mycoplasma hominis (20 strains) and ureaplasma urealyticum (100 strains) to minocycline and doxycycline was studied in vitro. minimal inhibitory concentrations were determined using an agar dilution method for m. pneumoniae and m. hominis and a metabolic inhibition test for u. urealyticum. m. pneumoniae strains were highly susceptible to minocycline and doxycycline (mic less than or equal to 0.1 mg/l). among m. hominis strains, 17 were suscep ...	1985	3937130
the association of sexually transmitted diseases with cervical intraepithelial neoplasia: a case-control study.	thirty-three women with histologically confirmed cervical intraepithelial neoplasia (grades i to iii, with one case of microinvasive carcinoma) and 54 women without evidence of the disease were prospectively studied to determine the relationship of genital infection to cervical neoplasia. demographic and sexual data for patients and control subjects were collected, with standardized clinical and colposcopic evaluation by means of predefined diagnostic categories. cultures from the cervix were ex ...	1985	2982264
tetracycline-resistant mycoplasma hominis strains contain streptococcal tetm sequences.	clinical isolates of mycoplasma hominis resistant to high levels of tetracycline contained dna sequences homologous to the streptococcal tetracycline determinant, tetm. in contrast, none of the susceptible m. hominis isolates tested carried this determinant. this is the first description of tetm in an unrelated genus and suggests the spread of tetm from streptococcus spp. to mycoplasma spp.	1985	2994555
[course of pregnancy and labor and pregnancy outcome for mother and fetus in women infected with mycoplasma hominis].		1985	2932010
human mycoplasmal infections: serologic observations.	three species of mycoplasmas have been implicated in human disease. mycoplasma pneumoniae, which causes upper respiratory infections, pneumonia, and other complications, is an uncommon isolate from the ororespiratory tract except during outbreaks of disease. mycoplasma hominis and ureaplasma urealyticum are the two principal species of genital mycoplasmas. these are responsible for some cases of urogenital infections, and more recent studies show that they are associated with perinatal disorders ...	1985	2408311
influence of ureaplasma urealyticum and mycoplasma hominis on the human spermatozoal motility.		1984	6480368
isolation of ureaplasma urealyticum and mycoplasma hominis from patients with genitourinary tract infection.		1984	6480371
mycoplasma hominis--a human pathogen.		1984	6505919
a prospective study of mycoplasma infection in the preterm infant.	the nasopharyngeal aspirates of 235 infants admitted to the neonatal intensive care unit over a 14-month period were tested for the presence of ureaplasma urealyticum and mycoplasma hominis. serological studies were carried out on 41 infants. u. urealyticum was isolated from 53 (22%) babies and was not associated with illness. there was a significant association between u. urealyticum colonization and preterm birth, low birth weight and prolonged rupture of membranes (prom). m. hominis was isola ...	1984	6511316
do mycoplasmas inhibit the human sperm fertilizing ability in vitro?	although clinical observations have suggested that ureaplasma urealyticum may be associated with reproductive failure, the role of ureaplasmas in human infertility remains controversial. however, the mechanism whereby ureaplasmas can interfere with the fertilization process is not known. to study possible mechanisms, we used the human sperm-hamster egg fertilization test. eggs were exposed to the spermatozoa preincubated with mycoplasma hominis or u. urealyticum (serotype 1-8). u. urealyticum se ...	1984	6511317
spontaneous abortion--an infectious aetiology?	the role of chlamydia trachomatis, genital mycoplasmas, campylobacter spp. and other aerobic and anaerobic bacteria in the aetiology of spontaneous abortion was investigated prospectively in 241 pregnant women at a community hospital. sixteen women who had threatened abortions were a little younger, of lower social class and had had more previous spontaneous abortions than the 76 women who aborted or the 149 women whose pregnancies were not complicated in the early stages by haemorrhage. the dem ...	1984	6518152
pelvic inflammatory disease after hysterosalpingography associated with chlamydia trachomatis and mycoplasma hominis.	a total of 116 women were referred for hysterosalpingography because of primary or secondary infertility. chlamydia trachomatis was isolated from the cervix of four (3.4%) of the patients whereas mycoplasma hominis was isolated from 39 (33.6%) of them. four patients developed acute pelvic inflammatory disease after hysterosalpingography; two of them were chlamydia culture-positive and developed a significant chlamydial antibody response during the course of the disease. one of the other two pati ...	1984	6518153
introductory address: microbial etiology of pelvic inflammatory disease.	the etiology of acute pelvic inflammatory disease is multifactorial, and the pattern of organisms most frequently causing the condition fluctuates. for example, tuberculous salpingitis has gradually become a rarity in many areas, and cases of nongonococcal salpingitis have started to outnumber those of gonococcal salpingitis. chlamydia trachomatis now causes more cases than neisseria gonorrhoeae in many regions. mycoplasma hominis is another (often overlooked) etiologic agent infection in the up ...	1984	6523323
[experimental magnesium ammonium phosphate lithiasis induced by ureaplasma in the rat].	struvite urinary stones are commonly associated with infections by urease possessing bacteria (proteus). ureaplasma urealyticum, a genital mycoplasma, is predominantly located in the human genito-urinary tract and produces urease. its possible role in the formation of infection stones was studied in the rat model described by friedlander and braude. struvite bladder stones were produced in 60% of sprague-dawley male rats after infection of ureaplasmas (serotype 1, 2, 3, 7) into the renal medulla ...	1984	6531060
[septicemia caused by mycoplasma hominis].	a patient with septicemia, caused by mycoplasma hominis was described. data were established for pyeloureteral anomalies in both ureters with disturbed left drainage with hydronephrosis ii--ii stage. mixed flora was isolated from urine--mycoplasma hominis and e. coli. pure culture mycoplasma hominis was isolated from the hemocultures. the patient was favourably affected by metacyclin treatment--600 mg daily.	1984	6531866
serological evidence implicating mycoplasma genitalium in pelvic inflammatory disease.	31 women with acute pelvic inflammatory disease, in whom serum antibodies to chlamydia trachomatis and mycoplasma hominis could not be detected, were examined for antibodies to mycoplasma genitalium by a microimmunofluorescence technique. about 40% of them had a fourfold or greater change in the titre of antibody during the one-month period after the onset of disease. this evidence implicates m genitalium in the aetiology of pelvic inflammatory disease.	1984	6144831
prevalence of six sexually transmitted disease agents among pregnant inner-city adolescents and pregnancy outcome.	115 pregnant girls aged 13-17 years were investigated during the third trimester for endocervical infection with six sexually transmissible microorganisms. specimens from 21 patients destroyed the tissue cell monolayers for propagation of chlamydia trachomatis, but 11 were no longer toxic when recultured after freezing or with additional antimicrobial agents; trichomonas vaginalis was present in 76% of the toxic specimens. c trachomatis was recovered from 37% of 105 specimens. t vaginalis was re ...	1984	6146874
association of ureaplasma urealyticum in the placenta with perinatal morbidity and mortality.	we investigated the presence of ureaplasmas, mycoplasmas, chlamydiae, fungi, aerobic and anaerobic bacteria, and cytomegalovirus in fetal membranes and evaluated their association with perinatal morbidity and mortality. we cultured 801 placentas from three groups of subjects (144 who died in the perinatal period, 452 neonates admitted to the intensive-care unit, and 205 controls). ureaplasma urealyticum, mycoplasma hominis, or both were isolated from 21 per cent of placentas of premature and ter ...	1984	6321990
a prospective study of chlamydial, mycoplasmal, and viral infections in a neonatal intensive care unit.	in a prospective study of non-bacterial infection in a neonatal intensive care unit in north west london, chlamydia trachomatis infection was identified in 4 of 280 babies (1.4%) and was the most common cause of neonatal ophthalmia. one of the four developed pneumonitis. ureaplasma urealyticum was found to colonise the nasopharynx in 53 of 235 babies (22.6%), with mycoplasma hominis present in 6 of 235 babies (2.6%). there was a statistically significant association between u urealyticum colonis ...	1984	6322705
vaginal colonization with gardnerella vaginalis and anaerobic curved rods.	ninety-four women colonized with anaerobic curved rods (cr) and/or gardnerella vaginalis, were studied. of these women, 34 were culture-positive for the long variant of cr. eight of these latter women also harboured the short variant of these bacteria. in women colonized with cr, none had a predominance of lactobacilli in their vaginal flora, which was the case in 26 of the 60 women not harbouring cr. g. vaginalis was isolated from all 94 women. mycoplasma hominis occurred significantly more oft ...	1984	6336131
immunoglobulin a protease activity of ureaplasma urealyticum.	all of 14 serotype standards and 34 of 35 wild-type strains of ureaplasma urealyticum isolated from humans demonstrated an immunoglobulin a (iga) protease activity. this activity degraded radiolabeled human iga including iga1 but not igg or azocasein. the iga fragments were detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, followed by radioautography, and they had molecular weights of about 110,000 and 50,000. the iga protease activity persisted in 25 mm edta but was sensiti ...	1984	6365962
detection of mycoplasma hominis antigen in clinical specimens by using a four-layer modification of enzyme immunoassay (eia).	a 4-layer modification of enzyme immunoassay (eia) was developed for the detection of mycoplasma hominis antigen in clinical specimens. microtiter plates were sensitized with rabbit anti-mycoplasma immunoglobulin, guinea pig anti-mycoplasma immunoglobulin was used as the secondary antibody, and horseradish peroxidase-conjugated anti-guinea pig immunoglobulin was used as the indicator antibody. the specificity of the assay was confirmed by using guinea pig immunoglobulins from preimmunization ser ...	1984	6371147
mycoplasmic localization patterns on spermatozoa from infertile men.	two mycoplasmas have been observed with increasing frequency in patients with genitourinary disorders: mycoplasma hominis and ureaplasma urealyticum. mycoplasma cells of both these species have been demonstrated to be capable of attaching to human spermatozoa of infertile patients. the mechanisms for the association of infertility and mycoplasma infection have not been established. the main objective of this article was to explain the significance of some morphologic features of spermatozoa of p ...	1984	6381102
the activity of ciprofloxacin and other 4-quinolones against chlamydia trachomatis and mycoplasmas in vitro.	ciprofloxacin was found to be the most active of a group of 4-quinolone antibiotics tested against the sa2f strain of chlamydia trachomatis (mbc and mic 1.0 mg/l). against genital isolates of chlamydia trachomatis, ciprofloxacin was twice as active as rosoxacin. ciprofloxacin showed similar activity to that of oxytetracycline against clinical isolates of mycoplasma hominis and ureaplasma urealyticum, and was 8-fold more active than rosoxacin against the latter.	1984	6237903
interaction between trichomonas vaginalis and other pathogenic micro-organisms of the human genital tract.	trichomonas vaginalis organisms were mixed with suspensions of neisseria gonorrhoeae, mycoplasma hominis or chlamydia trachomatis to allow ingestion of these micro-organisms by the trichomonads. culture studies indicated that gonococci and mycoplasmas were ingested and that the number of intracellular viable organisms decreased rapidly, most gonococci being killed within six hours and all mycoplasmas within three hours. electron microscopy revealed phagocytic uptake and destruction of these two ...	1984	6421451
effects of manganese on the growth and morphology of ureaplasma urealyticum.	all of the 14 serotype standard strains of ureaplasma urealyticum were inhibited to varying degrees by manganese. a 1 mm concentration of this cation either stopped growth or reduced the rate of growth in liquid medium. the presence of manganese also altered colonial morphology and cellular ultrastructure. inhibition was dose dependent and strain specific. this differential response allowed the serotype strains to be divided into two broad biotypes. for the first biotype (serotypes 1, 3, 6, and ...	1984	6432835
lack of association between genital mycoplasmas and infertility.	we studied the relation between colonization with mycoplasma hominis and ureaplasma urealyticum, and the results of infertility studies in 205 women with involuntary infertility of at least one year's duration. isolation of m. hominis (but not of u. urealyticum) was significantly (p = 0.002) more common in patients with a history of pelvic inflammatory disease. however, no relation could be shown between these genital mycoplasmas and any of the following: evidence of prior pelvic inflammatory di ...	1984	6700691
the importance and frequency of mixed infections with chlamydia trachomatis and mycoplasmas in acute gonococcal urethritis.	chlamydia trachomatis, ureaplasma urealyticum and mycoplasma hominis are frequently involved in gonococcal urethritis. we investigated 143 male white and black patients with gonococcal urethritis (average age 22,5 years). of these 29% had coexisting chlam. trachomatis infection, 34% u. urealyticum infection and 13% mycoplasma hominis infection. conventional penicillin therapy did not affect chlam. trachomatis, u. urealyticum or mycoplasma hominis, which persisted in the lower urogenital tract, c ...	1984	6701710
mycoplasma infections of the human urogenital tract with particular reference to non-gonococcal urethritis.	the criteria which need to be fulfilled before regarding a microorganism as a cause of non-gonococcal urethritis (ngu) are considered in relation to mycoplasma hominis, ureaplasma urealyticum and m. genitalium. there is no evidence to support an aetiological role for m. hominis, but few appropriate investigations have been undertaken. the criteria have been met, for the most part, in the case of u. urealyticum, but further quantitative studies are required. the role of m. genitalium is unknown, ...	1984	6712055
in vitro activity of clindamycin against strains of chlamydia trachomatis, mycoplasma hominis, and ureaplasma urealyticum isolated from pregnant women.	chlamydia trachomatis, mycoplasma hominis, and ureaplasma urealyticum are genital agents that are being increasingly implicated in infectious pregnancy complications and abnormal pregnancy outcomes. we measured the in vitro activity of clindamycin against strains of these three agents which were isolated from pregnant women. for 30 strains of c. trachomatis, the median minimal inhibitory concentration was 1.0 microgram/ml (range, 0.25 to 2.0 micrograms/ml). for 27 strains of m. hominis, the medi ...	1984	6742014
the co-existence of genital mycoplasma and neisseria gonorrhoeae isolated from the male urethra.	ureaplasma urealyticum and mycoplasma hominis, separately or together, were co-isolated along with 34 of 102 strains of neisseria gonorrhoeae cultured from urethral swabs from men with urethritis. for approximately half of the n. gonorrhoeae strains, the mycoplasma(s) persisted for at least five passages on agar medium. u. urealyticum was isolated in 31 of the 34 instances. no association between particular serotype(s) of u. urealyticum or auxotypes of n. gonorrhoeae was identified. the auxotype ...	1984	6438816
the etiology of pelvic inflammatory disease.	the etiology of pelvic inflammatory disease (pid) is speculated upon based on reported incidence and epidemiological studies. in western society, the incidence of pid (annual) is 1% among women aged 15-34 years and 2% in the high risk group of women aged 15-24 years. the annual incidence in the us is higher, at least 2% among fecund sexually active women aged 13-44 years. the medical consequences of pid are infertility, ectopic pregnancy, and chronic pelvic pain. causative agents include nei ...	1984	12179634
the role of mycoplasmas in non-gonococcal urethritis: a review.	the criteria that need to be fulfilled before regarding a mycoplasma as a cause of non-gonococcal urethritis (ngu) are outlined. of the seven mycoplasmas that have been isolated from the human genitourinary tract, most cannot be considered as contenders for causing ngu. although there is no evidence to support an etiological role for mycoplasma hominis, it may be unwise to ignore this mycoplasma in view of its known pathogenicity in other situations. the cumulative weight of evidence indicates t ...	1983	6433572
mycoplasmal pid: a review of natural and experimental infections.	the present report is a review of data assuming an etiological relationship between pelvic inflammatory disease (pid) and mycoplasma hominis. thus the organism can be isolated from the vagina/cervix more frequently in pid patients than in any other clinical group, i.e., in half to three-fourths of all such cases. one-fourth of pid patients develop a significant antibody response to m. hominis during the course of the disease. the antibody response can be detected by indirect hemagglutination tes ...	1983	6382823
[gonorrheal urethritis--frequently a mixed chlamydia and mycoplasma infection. results in 143 male patients with acute gonorrhea].	chlamydia trachomatis, ureaplasma urealyticum and mycoplasma hominis are frequently demonstrated in cases of acute gonorrhoeic urethritis. among 143 males (average age 22.5 years) chlamydia was demonstrated in 29%, u. urealyticum in 34% and m. hominis in 13%. penicillin treatment of gonorrhoea does not affect chlamydia and mycoplasma so that these organisms will persist in the lower urogenital tract. generally postgonorrhoeic urethritis is associated with chlamydia or mycoplasma infection. nearl ...	1983	6406199
mycoplasma hominis septicaemia.	mycoplasma hominis septicaemia occurred in a patient with a malignant lymphoma of lymphoblastic type in leukaemic phase. m hominis was isolated several times from blood cultures with antibody titres against the micro-organism rising to a high level despite severe immunosuppression. m hominis was detected in the blood after subculture of the blood culture bottles despite their macroscopically normal appearance. the patient's pyrexia resolved without treatment with antibiotics effective against m ...	1983	6409207
the genetic relation between mycoplasma hominis and other mycoplasma species.	purified preparations of dna from five mycoplasma species of human origin, including mycoplasma hominis, were analyzed for homology. in general, very low-level homology (less than 0.5%) was found, but two pairs of species showed greater homology: m. hominis and mycoplasma salivarium were related by a 2.6% homology, mycoplasma pneumoniae and mycoplasma genitalium (a proposed new species) were related by a 1.8% homology. these results indicate that the species involved are distinct but distantly r ...	1983	6420911
application of monoclonal antibodies to detect intraocular mycoplasma antigens in mycoplasma arthritidis-infected sprague-dawley rats.	sprague-dawley rats infected with mycoplasma arthritidis by tail vein inoculation develop extensive disseminated joint inflammation, frequently accompanied by conjunctivitis and anterior uveitis. the intraocular inflammation is apparently directed at mycoplasmas localized within the stroma of the ciliary body, which have been detected with monoclonal antibodies by indirect immunofluorescence. the monoclonal antibodies are directed against an antigenic determinant on the enzyme arginine deiminase ...	1983	6339406
septicaemia in a renal transplant patient due to mycoplasma hominis.	opportunistic infections are an important cause of mortality in transplant patients. here we report a case of mycoplasma hominis septicaemia in a renal transplant patient that was successfully treated with doxycycline.	1983	6350477
mycoplasma hominis - a neglected human pathogen.		1983	6354713
mycoplasma hominis: historical outline and taxonomy.	although known as a separate group of organisms since 1898, the isolation in 1937 of a human genital mycoplasma represented the first observation of the association of this group of organisms with humans, a discovery that provided the impetus for extensive investigations of the interactions of mycoplasmas with the human host. these studies showed that mycoplasmas were frequent inhabitants of the mucous membranes of the urogenital and upper respiratory tracts. in early studies of human mycoplasma ...	1983	6364403
morphology of the cells and colonies of mycoplasma hominis.	studies of the morphology mycoplasma hominis have shown that the cells resemble those of small coccoid or ovoid bacteria; the microstructure of the organism is compatible with reproduction by a fission process. although dividing forms with equal-sized lobes are common, fragmenting filaments and replicating buds sometimes occur, perhaps in response to suboptimal growth conditions. data based on morphometric analysis show that cells of m. hominis atcc 14027 have average dimensions of 0.27 x 0.74 m ...	1983	6364404
enzyme immunoassay for serum antibody to mycoplasma hominis in women with acute pelvic inflammatory disease.	a sensitive, four-layer modification of an enzyme immunoassay was developed for the determination of serum antibodies to mycoplasma hominis. the suitability of the test for diagnostic use was studied with women who had acute pelvic inflammatory disease (pid). twenty (23%) of 86 women with pid from whom paired sera were obtained demonstrated a significant change in levels of igg antibody, a finding suggestive of recent infection with m. hominis. the occurrence of such change was not related to th ...	1983	6364405
occurrence and pathogenicity of mycoplasma hominis in the upper urinary tract: a review.	in two studies mycoplasma hominis was isolated from the upper urinary tracts of seven of 80 patients with symptoms of acute pyelonephritis and three of 18 patients with signs of acute exacerbation of chronic pyelonephritis. m. hominis was not recovered from the upper urinary tract of 22 patients with chronic pyelonephritis without acute exacerbation or from 60 patients with noninfectious urinary tract disease. in an additional study, specimens were cultured from patients with antibodies to m. ho ...	1983	6364406
antimicrobial susceptibility and susceptibility testing of mycoplasma hominis: a review.	the determination of the minimal growth-inhibiting concentration (mic), the minimal metabolism-inhibiting concentration (mmc), and the minimal mycoplasmacidal concentration (mcc) of various antimicrobial compounds for mycoplasma hominis is influenced by the ph of the test media, the inoculum size, and the incubation time, although each of these factors generally do not affect the minimal concentration more than fourfold. m. hominis is resistant to beta-lactam antibiotics, vancomycin, sulfonamide ...	1983	6364407
mycoplasma hominis- tissue cell interactions: a review with new observations on phenotypic and genotypic properties.	strains of mycoplasma hominis isolated from different tissues of patients with a variety of disease processes and from cell culture substrates show marked phenotypic and genotypic heterogeneity, as determined by their antigenic and isozyme properties and by [3h]dna-dna hybridization and dna cleavage pattern analyses. strains isolated from the same tissues (blood of postpartum patients or human urogenital tract or cell culture substrates) have very high genomic homology and form clusters of simil ...	1983	6198734
in vitro activity of norfloxacin against mycoplasma hominis and ureaplasma urealyticum.		1983	6227484