Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| propionibacterium acnes: a rare cause of late prosthetic valve endocarditis and aortic root abscess. | propionibacterium acnes is an anaerobic, non-spore forming, gram-positive bacillus, and is often part of the normal flora of human skin. it usually has relatively low virulence. however, it can rarely cause serious infections including infections of prosthetic valves, native valves, and annuloplasty rings. we describe a rare case of late prosthetic aortic valve endocarditis and aortic root abscess caused by p. acnes, an easily ignored pathogen. | 2008 | 18199505 |
| sebocytes express functional cathelicidin antimicrobial peptides and can act to kill propionibacterium acnes. | 2008 | 18200058 | |
| a new phylogenetic group of propionibacterium acnes. | immunofluorescence microscopy-based identification of presumptive propionibacterium acnes isolates, using the p. acnes-specific mab qubpa3, revealed five organisms with an atypical cellular morphology. unlike the coryneform morphology seen with p. acnes types i and ii, these isolates exhibited long slender filaments (which formed large tangled aggregates) not previously described in p. acnes. no reaction with mabs that label p. acnes types ia (qubpa1) and ii (qubpa2) was observed. nucleotide seq ... | 2008 | 18201989 |
| [inducible histamine protects mice from hepatitis through h2-receptor stimulation]. | histamine is well known for its roles in allergic diseases and anaphylaxis through h(1)-receptor stimulation. the h(1)-receptor stimulation by histamine results in an increase in vascular permeability, vasodilatation, and stimulation of nerve terminals in primary sensory neurons, thereby accelerating the inflammatory responses. on the other hand, histamine has been demonstrated to be involved in the regulation of innate and acquired immune responses through h(2)-receptors. in a previous study wi ... | 2008 | 18239372 |
| chemical composition and biological activities of essential oils extracted from korean endemic citrus species. | the aim of this study was to analyze the chemical composition of 14 kinds of citrus oils and to test their biological activities. citrus essential oils were obtained by steam distillation from immature fruits collected from jeju island and were analyzed using gas chromatograph (gc)- flame ionization detectors (fid) and gc-ms. limonene (55.4% to 91.7%), myrcene (2.1% to 32.1%), alpha-pinene (0.6% to 1.6%) and linalool (0.4% to 6.9%) were the major components in most citrus species. to evaluate in ... | 2008 | 18239420 |
| early bacterial keratitis after presbyopic lasik. | to report an unusual case of infectious keratitis that occurred after presbyopic laser-assisted in situ keratomileusis (lasik). | 2008 | 18245979 |
| vaccination targeting a surface sialidase of p. acnes: implication for new treatment of acne vulgaris. | acne vulgaris afflicts more than fifty million people in the united state and the severity of this disorder is associated with the immune response to propionibacterium acnes (p. acnes). systemic therapies for acne target p. acnes using antibiotics, or target the follicle with retinoids such as isotretinoin. the latter systemic treatment is highly effective but also carries a risk of side effects including immune imbalance, hyperlipidemia, and teratogenicity. despite substantial research into pot ... | 2008 | 18253498 |
| ultrastructural findings in progressive macular hypomelanosis indicate decreased melanin production. | the pathogenesis of progressive macular hypomelanosis (pmh) is unknown. recently, westerhof et al. (arch dermatol 2004; 140: 210-214) hypothesized that propionibacterium acnes produces a depigmenting factor that interferes with melanogenesis in the skin, resulting in hypopigmented spots. the purpose of the study is to gain an insight into the pathogenesis of pmh. | 2008 | 18266692 |
| skin microbiota: a source of disease or defence? | microbes found on the skin are usually regarded as pathogens, potential pathogens or innocuous symbiotic organisms. advances in microbiology and immunology are revising our understanding of the molecular mechanisms of microbial virulence and the specific events involved in the host-microbe interaction. current data contradict some historical classifications of cutaneous microbiota and suggest that these organisms may protect the host, defining them not as simple symbiotic microbes but rather as ... | 2008 | 18275522 |
| n-substituted 3-acetyltetramic acid derivatives as antibacterial agents. | in order to expand the structure-activity relationship of tetramic acid molecules with structural similarity to the antibiotic reutericyclin, 22 compounds were synthesized and tested against a panel of clinically relevant bacteria. key structural changes on the tetramic acid core affected antibacterial activity. various compounds in the n-alkyl 3-acetyltetramic acid series exhibited good activity against gram-positive bacterial pathogens including bacillus anthracis, propionibacterium acnes, ent ... | 2008 | 18281930 |
| revision shoulder arthroplasty for glenoid component loosening. | although glenoid component loosening has been recognized as a common reason for failure after total shoulder arthroplasty, there are few studies on the outcome of revision surgery for this problem. the purpose of this study is to determine the outcome of patients who underwent revision for glenoid component loosening. between 1976 and 2002, 68 shoulders in 66 patients underwent revision for glenoid loosening at our institution. group i consisted of 33 shoulders that underwent placement of a new ... | 2008 | 18282720 |
| a peptide with a progln c terminus in the human saliva peptidome exerts bactericidal activity against propionibacterium acnes. | nine proline-rich peptides ending with a proline-glutamine c terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. a gpppqggrpq peptide binds gram-positive propionibacterium acnes and considerably inhibits bacterial growth. the peptide exhibiting innate immunity may be applied for treatment of various p. acnes-associated human diseases. | 2008 | 18285475 |
| ascending aortic pseudoaneurysm: a late complication of coronary artery bypass. | 2008 | 18292416 | |
| direct aspiration of capsular bag material in a case of sequestered endophthalmitis. | chronic recurrent endophthalmitis can occur following uncomplicated cataract surgery with intraocular lens implantation secondary to organisms sequestered in the capsular bag. there is a need to identify these sequestered organisms to facilitate appropriate management. frequently, specimens from the anterior chamber and vitreous cavity could be unyielding, especially in the early cases in which the vitreous is still uninvolved. this article highlights the technique of directly sampling the capsu ... | 2008 | 18292631 |
| infection after the surgical treatment of adolescent idiopathic scoliosis: evaluation of the diagnosis, treatment, and impact on clinical outcomes. | retrospective case-control. | 2008 | 18303461 |
| a young man with propionibacterium acnes-induced shunt nephritis. | 2008 | 18322539 | |
| [granulomatous diseases and pathogenic microorganism]. | granuloma formation is a chronic inflammatory reaction where macrophage system and other inflammatory cells are involved. after some antigen exposure and processing, t cells, macrophages, epithelioid cells, and giant cell are activated, and granulomas are formed. granuloma is considered as a defense mechanism against antigens, which stay in the organs without inactivation. granulomas including fibroblasts extra-cellular matrix surround and isolate the antigens. granulomas are classified to nonin ... | 2008 | 18326339 |
| the antibody response to propionibacterium acnes is an independent predictor of serum prostate-specific antigen levels in biopsy-negative men. | to investigate whether the serum titres of propionibacterium acnes antibodies in patients undergoing prostate biopsy are associated with prostate cancer or markers of prostate disease, including serum prostate-specific antigen (psa) levels. | 2008 | 17850358 |
| biofilm formation of the pathogens of fatal bacterial granuloma after trauma: potential mechanism underlying the failure of traditional antibiotic treatments. | the pathogen of a new type of disease - fatal bacterial granuloma after trauma (fbgt) - was found to be propionibacterium acnes (p. acnes). although in vitro studies showed that the pathogenic p. acnes are sensitive to conventional antibiotics, treatments of fbgt patients with these antibiotics were ineffective. the underlying mechanisms were not clear. since p. acnes are able to form biofilm on orthopaedic biomaterials in vitro, and pathogenic p. acnes of acnes vulgaris was known to form biofil ... | 2008 | 17852906 |
| anti-acne activity of selaginella involvens extract and its non-antibiotic antimicrobial potential on propionibacterium acnes. | acne is a typical condition of adolescence and is caused by multi-factorial events including hormonal, microbiological and immunological mechanisms. although there has been much debate about the direct involvement of bacteria, propionibacterium acnes is now believed to contribute to the inflammatory stages of the condition, and thus initiate the inflamed lesion. the present study examined the anti-acne properties of the selaginella involvens extract (sie) in cell models. primarily, sie was not f ... | 2008 | 17926337 |
| the ectopeptidases dipeptidyl peptidase iv (dp iv) and aminopeptidase n (apn) and their related enzymes as possible targets in the treatment of skin diseases. | skin cells express dipeptidyl peptidase iv (dp iv) and aminopeptidase n (apn) and their related molecules of the dp iv-like family dp2, dp6, dp8, dp9 and fibroblast activation protein (fap), as well as the cytoplasmic alanyl aminopeptidase (caap). the inhibitors of dp iv-like activity, lys(z(no2))-thiazolidide (lznt) and lys(z(no2))-pyrrolidide (lznp), and the apn inhibitors actinonin and bestatin affect proliferation, differentiation and cytokine production in sebocytes and keratinocytes, which ... | 2008 | 17981718 |
| propionibacterium acnes stimulates pro-matrix metalloproteinase-2 expression through tumor necrosis factor-alpha in human dermal fibroblasts. | propionibacterium acnes (p. acnes) is a commensal microorganism found in sebum-rich skin and plays a role in acne inflammation by stimulating keratinocyte to produce a number of proinflammatory cytokines. however, the role of p. acnes in the dermis of acne lesions, where tissue remodeling after inflammation eventually takes place, is not known. in this study, we investigated whether p. acnes induces matrix metalloproteinase (mmp), a key enzyme involved in matrix remodeling in human dermal fibrob ... | 2008 | 18049448 |
| pathological findings in the lens capsules and intraocular lens in chronic pseudophakic endophthalmitis: an electron microscopy study. | the aim of this study was to describe the pathological findings in lens capsules and intraocular lens (iol) studied by scanning and/or transmission electron microscopy (sem and tem, respectively) in a series of four eyes with chronic pseudophakic endophthalmitis (cpe). | 2008 | 17041575 |
| anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-cox-2-pge2 pathway. | sertaconazole nitrate is an antifungal agent that exhibits anti-inflammatory activity; however, the mechanism for this action was unknown. we investigated the cellular mechanisms by which sertaconazole exerts its anti-inflammatory activity in keratinocytes and human peripheral blood mononuclear cells (pbmcs). paradoxically, sertaconazole was found to activate the proinflammatory p38 mitogen-activated protein kinase. treatment with sertaconazole also resulted in the induction of cyclooxygenase-2 ... | 2008 | 17637821 |
| cloning and expression of antibacterial goat lactoferricin from escherichia coli ad494(de3)plyss expression system. | goat lactoferricin (glfcin), an antibacterial peptide, is released from the n terminus of goat lactoferrin by pepsin digestion. two glfcin-related cdnas, glfcin l and glfcin s, encoding ala20-ser60 and ser36-ser60 of goat lactoferrin, respectively, were cloned into the pet-23a(+) expression vector upstream from (his)6-tag gene and transformed into escherichia coli ad494(de3)plyss expression host. after being induced by isopropyl-beta-d-thiogalactopyranoside (iptg), two (his)6-tag fused recombina ... | 2008 | 19244908 |
| the evolution of benzoyl peroxide therapy. | since its first use in dermatology last century, benzoyl peroxide (bpo) has undergone a number of reformulations, each enhancing its efficacy, tolerability, or both. benzoyl peroxide can be used as monotherapy or in combination with oral or topical antibiotics or topical retinoids. its antimicrobial activity is based on the generation of highly reactive oxygen radicals, a physicochemical effect to which propionibacterium acnes has not developed resistance. in addition to its nonspecific antimicr ... | 2008 | 19202772 |
| selection of therapy for acne vulgaris: balancing concerns about antibiotic resistance. | the widespread use of long-term antibiotics to treat acne and rosacea has resulted in increased propionibacterium acnes resistance to antibiotics. although resistance may decrease treatment effectiveness in some cases, it also is clear that antimicrobial activity is not the only role antibiotics play in acne management. the anti-inflammatory activity of antibiotics contributes to antipropionibacterial efficacy. in addition, the use of benzoyl peroxide (bpo) in combination with antibiotics to red ... | 2008 | 19202773 |
| antibiotic-resistant propionibacterium acnes suppressed by a benzoyl peroxide cleanser 6%. | adding topical benzoyl peroxide (bpo) to antibiotics can reduce resistant propionibacterium acnes in patients with acne receiving antibiotic therapy. benzoyl peroxide often is formulated as a wash, but no published data exist regarding bpo wash formulation efficacy in reducing resistant strains of p acnes. this 3-week, open-label, single-center study evaluated the effects of bpo cleanser 6% on antibiotic-resistant p acnes populations. the study involved 30 healthy adults who were free of acne bu ... | 2008 | 19181031 |
| the effect of propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells. | propionibacterium acnes (p. acnes) has been implicated in the pathogenesis of acne vulgaris which is the most common cutaneous disorder. it has a proinflammatory activity and takes part in immune reactions modulating the th1/th2 cellular response. the exposure of dendritic cells (dcs) to whole bacteria, their components, cytokines or other inflammatory stimuli and infectious agents induces differentiation from immature dcs into antigen-presenting mature dcs. the aim of the study was to evaluate ... | 2008 | 19141410 |
| antimicrobial susceptibilities of propionibacterium acnes isolated from patients with acne vulgaris. | antibiotic susceptibilities of propionibacterium acnes in japan were determined. erythromycin-resistance was found in 10.4% (5/48) of the strains, and four of these were cross-resistance to clindamycin. although the erythromycin ribosome methylase gene erm(x) was looked for, no strain carrying erm(x) was found. sequencing analysis revealed that all of the erythromycin-resistant strains had a mutation in the peptidyl transferase region of the 23s rrna gene: g2057a, a2058g, or a2059g. consequently ... | 2008 | 19120976 |
| sterility screening of platelet concentrates: questioning the optimal test strategy. | routine bacterial monitoring of apheresis platelet concentrates (apc) and pooled platelet concentrates (ppc) was introduced in two german blood services using culture and real-time reverse transcriptase (rt)-polymerase chain reaction (pcr). the results of testing are reviewed and used to discuss different strategies for detection of bacterial contamination of pcs. | 2008 | 19121182 |
| significance of propionibacterium acnes-positive samples in spinal instrumentation. | a retrospective study about propionibacterium acnes infections after cotrel-dubousset (cd) instrumentation. | 2008 | 19092607 |
| acne is not associated with yet-uncultured bacteria. | current clinical and microbiological information on acne fails to demonstrate a clear association between particular species, including propionibacterium acnes, and disease, and the disease continues to be a considerable problem. to test if acne is associated with hitherto uncultured bacteria residing in diseased skin follicles, sequencing and phylogenetic analysis of approximately 5,700 amplified and cloned 16s rrna genes were used to determine the microbial diversity in follicles from acne pat ... | 2008 | 18716234 |
| generation of human monoclonal antibodies against propionibacterium acnes by applying the phage display method to human peripheral blood mononuclear cells immunized in vitro. | propionibacterium acnes is a gram-positive, non-spore-forming, rod-shaped bacterium that is often detected in normal human skin flora. p. acnes has been associated with many diseases. in this study, we attempted to generate anti-p. acnes human monoclonal antibodies. a phage antibody library was first generated from human peripheral blood mononuclear cells immunized in vitro with p. acnes using the phage display method, and p. acnes-specific phage antibodies were obtained using solid phase pannin ... | 2008 | 19003162 |
| modulation of the type i hypersensitivity late phase reaction to ova by propionibacterium acnes-soluble polysaccharide. | late phase reaction (lpr) of immediate hypersensitivity is a th2 response characterized by eosinophil recruitment and related to allergic asthma pathogenesis. several strategies were developed trying to control the tissue damage observed in this reaction. recently, we verified that killed propionibacterium acnes (p. acnes), a gram-positive bacillus, immunomodulated lpr in a murine model, potentiating or suppressing it depending on the treatment protocol used. however, the bacterium compounds res ... | 2008 | 19014971 |
| bacterial contamination of surgeons gloves during shunt insertion: a pilot study. | bacterial infection is a major cause of shunt dysfunction. it is well-known that the majority of pathogenic micro-organisms are low-virulent bacteria normally found on intact skin. probably shunts become contaminated during surgery either by contact to the patient skin, or contact from contaminated gloves or instruments. this study was performed to find out to what extent gloves become contaminated during shunt surgery. gloves used during shunt implantation were examined in 10 operations. shunt ... | 2008 | 19016119 |
| antimicrobial activity of iodoquinol 1%-hydrocortisone acetate 2% gel against ciclopirox and clotrimazole. | commercially available topical formulations consisting of iodoquinol 1%-hydrocortisone acetate 2%, ciclopirox 0.77%, and clotrimazole 1%-betamethasone dipropionate 0.5% were assessed for their antimicrobial activity against cultures of micrococcus luteus, propionibacterium acnes, methicillin-resistant staphylococcus aureus (mrsa), pseudomonas aeruginosa, corynebacterium aquaticum, trichophyton mentagrophytes, malassezia furfur, microsporum canis, candida albicans, trichophyton rubrum, or epiderm ... | 2008 | 19055171 |
| infective endocarditis caused by anaerobic bacteria. | this review summarizes the microbiology, diagnosis and management of infective endocarditis (ie) due to anaerobic bacteria. anaerobic bacteria are an uncommon but important cause of ie. most cases are caused by the anaerobic and microaerophilic streptococci propionibacterium acnes, bacteroides fragilis and clostridium species. predisposing factors and signs and symptoms of ie caused by anaerobic bacteria are similar to those seen in ie due to facultative anaerobic bacteria with the following exc ... | 2008 | 19056073 |
| when a commensal becomes a pathogen. | 2008 | 19070255 | |
| quantitative analysis of propionibacterial dna in bronchoalveolar lavage cells from patients with sarcoidosis. | the causes of sarcoidosis are still unknown. propionibacterial subspieces are thought to be one of the most likely sources of antigens. here we attempted to measure the amount of propionibacterial dna in bronchoalveolar lavage (bal) cell samples from patients with sarcoidosis and other pulmonary diseases. | 2008 | 19070256 |
| [infectious osteoarthritis due to propionibacterium acnes]. | 2008 | 19087834 | |
| benzoyl peroxide cleansers for the treatment of acne vulgaris: status report on available data. | benzoyl peroxide (bpo) cleansers are commonly prescribed for treatment of acne vulgaris. in fact, they represent approximately half of all bpo prescriptions from dermatology practices. data are limited on the ability of bpo cleansers to reduce counts of propionibacterium acnes, impact on reduction and emergence of antibiotic-resistant p acnes strains, and efficacy for facial and truncal acne vulgaris. this article discusses available data on bpo cleanser formulations. | 2008 | 19090337 |
| inflammation and prostate cancer: a focus on infections. | despite accumulating evidence that inflammation may affect the development of prostate cancer, responsible causes of intraprostatic inflammation remain elusive. this review presents epidemiologic literature on infections, particularly sexually transmitted and other ascending urogenital infections, as possible causes of intraprostatic inflammation and/or prostate cancer. study results are interpreted in light of the inflammatory and carcinogenic potential of each infectious agent, as well as the ... | 2008 | 18765120 |
| biofilms in skin infections: propionibacterium acnes and acne vulgaris. | it is generally accepted that many human infections are biofilm-related and that sessile (biofilm-grown) cells are highly resistant against antimicrobial agents. propionibacterium acnes plays a role in the pathogenesis of acne vulgaris, a common disorder of the pilosebaceous follicles and it has been suggested that p. acnes cells residing within the follicles grow as a biofilm. although p. acnes biofilms have not been observed directly in the pilosebaceous unit, the observation that p. acnes rea ... | 2008 | 18782032 |
| vaccine therapy for p. acnes-associated diseases. | recent studies have afforded abundant evidences showing that propionibacterium acnes (p. acnes) is involved not only in acne vulgaris, but also in many diseases, including endocarditis, endophthalmitis, osteomyelitis, joint, nervous system, cranial neurosurgery infections, and implanted biomaterial contamination. in spite of a range of p. acnes pathogenicity, its vaccine therapies have been studied much less intensively than antibiotic therapies which have been mainstay of treatment for p. acnes ... | 2008 | 18782033 |
| acne vaccines: therapeutic option for the treatment of acne vulgaris? | acne, one of the most common skin diseases, is caused by multiple factors, including propionibacterium acnes. studies suggest that responses to p. acnes by host immunity play important roles in its pathogenesis. identifying immune modulators that attenuate inflammatory responses against p. acnes and the inhibition of bacterial growth may lead to novel avenues of immunologic intervention. | 2008 | 18787542 |
| an assessment of the efficacy of blue light phototherapy in the treatment of acne vulgaris. | acne vulgaris is a common skin condition that affects 8 out of 10 people. it varies from mild to severe, and different treatments target various aspects of the disease. propionibacterium acnes, one of the culprits involved in the pathogenesis of acne vulgaris, is the main target of all major medical treatments used. studies conducted in recent years have shown favorable effects within the visible light spectrum for the treatment of acne vulgaris. | 2008 | 18789052 |
| bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion. | toll-like receptors (tlrs) expressed on both immune cells and hepatocytes recognize microbial danger signals and regulate immune responses. previous studies showed that tlr9 and tlr2 mediate propionibacterium acnes-induced sensitization to lipopolysaccharide-triggered acute liver injury in mice. ligand-specific activation of tlr2 and tlr9 are dependent on the common tlr adaptor, myeloid differentiation factor 88 (myd88). here, we dissected the role of myd88 in parenchymal and bone marrow (bm)-de ... | 2008 | 18798338 |
| air-borne microbial contamination of surfaces in a uk dental clinic. | little is known about the number, type, or antibiotic resistance profiles, of air-borne microbes present in hospital settings yet such information is important in designing effective measures to reduce cross-infection. in this study settle plates were used to identify and quantify the air-borne microbes present in a dental clinic. all isolates were identified to species level using partial 16s ribosomal rna gene sequencing and their susceptibility to ampicillin, chloramphenicol, erythromycin, ge ... | 2008 | 18802318 |
| non-invasive diagnostic evaluation of phototherapeutic effects of red light phototherapy of acne vulgaris. | during the past few years, various phototherapeutic protocols with full-spectrum visible light or selected wavebands have been investigated in the treatment of acne vulgaris with variable results. | 2008 | 18811865 |
| a case of polymicrobial keratitis violating an intact lens capsule. | to report a case of polymicrobial keratitis resistant to topical and intraocular antibiotics with recurrence after penetrating keratoplasty. | 2008 | 18812771 |
| selection of serotype-specific vaccine candidate genes in actinobacillus pleuropneumoniae and heterologous immunization with propionibacterium acnes. | actinobacillus pleuropneumoniae (a. pleuropneumoniae) is a highly contagious lethal causative agent of swine pleuropneumoniae. vaccines for this disease are usually serotype specific. in order to identify immunogenic genes specific to serotypes, two differentially expressed gene cdna libraries of a. pleuropneumoniae ccvc259 (serotype 1) and ccvc263 (serotype 5) had been constructed by using a cdna representational difference analysis (cdna-rda). from the libraries, six potential vaccine candidat ... | 2008 | 18835316 |
| biological activities of korean citrus obovoides and citrus natsudaidai essential oils against acne-inducing bacteria. | this study was designed to analyze the chemical composition of citrus obovoides (geumgamja) and citrus natsudaidai (cheonyahagyul) oils and to test their biological activities. these citrus essential oils were obtained by steam distillation of fruits collected from jeju island, korea, and were analyzed using gas chromatograph (gc)-flame ionization detectors (fid) and gc-ms. limonene and gamma-terpinene were the major components of the two citrus species. to evaluate in vitro anti-acne activity, ... | 2008 | 18838824 |
| [postoperative intra-abdominal abscess with bacteremia due to propionibacterium acnes]. | 2008 | 18842245 | |
| [propionibacterium acnes endocarditis on an aortic prosthesis in a patient carrying a pacemaker]. | 2008 | 18842370 | |
| assessment of the bacterial diversity of human colostrum and screening of staphylococcal and enterococcal populations for potential virulence factors. | in contrast to breast milk, little is known about the bacterial composition of human colostrum. the objective of this work was to analyze the bacterial diversity of colostrum obtained from healthy women and to characterize the dominant bacterial species for the presence of possible virulence factors. samples of colostrum obtained from 36 healthy women were inoculated into different culture media. several isolates from each medium were selected and identified. staphylococcal and enterococcal isol ... | 2008 | 18845249 |
| antibiotic use in acne vulgaris and rosacea: clinical considerations and resistance issues of significance to dermatologists. | antibiotics are commonly prescribed in dermatology practice for a variety of disorders, including acne vulgaris and rosacea. importantly, they often are used long-term for these inflammatory dermatoses. changes in bacterial ecology related to antibiotic prescribing have led to the decreased sensitivity of some bacterial organisms, such as propionibacterium acnes, to antibiotics commonly prescribed by dermatologists. the potential clinical outcomes of altered bacterial sensitivities may vary amon ... | 2008 | 18924545 |
| novel endo-alpha-n-acetylgalactosaminidases with broader substrate specificity. | in an effort to identify novel endo-alpha-n-acetylgalactosaminidases (endo-alpha-galnacases), four potential genes were cloned. three of the expressed proteins engef from enterococcus faecalis, engpa from propionibacterium acnes, and engcp from clostridium perfringens were purified and characterized. their substrate specificity was investigated and compared to the commercially available endo-alpha-galnacases from streptococcus pneumoniae (engsp) and alcaligenes sp. (engal). all enzymes were incu ... | 2008 | 18635885 |
| influence of 16s rdna primer sequence mismatches on the spectrum of bacterial genera detected in prostate tissue by universal eubacterial pcr. | propionibacterium sp. and staphylococcus spp. are the most frequent bacteria cultured from prostatectomy specimens but are seldom detected by universal eubacterial pcr. | 2008 | 18651564 |
| an evaluation of pcr primer sets used for detection of propionibacterium acnes in prostate tissue samples. | multiple studies have now shown that propionibacterium acnes can be cultured from post-prostatectomy derived prostate tissue samples. in contrast, both universal eubacterial 16s rdna pcr and p. acnes-specific 16s rdna pcr have failed to detect this organism at a frequency similar to that of bacterial culture. a potential explanation for this discrepancy, proposed by cohen et al., involves mismatches in 16s rdna primer sets used for bacterial detection. | 2008 | 18651578 |
| bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to propionibacterium acnes infection in vivo. | acne is a human disease of the sebaceous hair follicle. unlike humans, most animals produce little or no triglycerides in hair follicles to harbor propionibacterium acnes a fact that has encumbered the development of novel treatments for acne lesions. although genetic mutant mice with acne-like skins have been used for screening anti-acne drugs, the mice generally have deficits in immune system that turns out to be inappropriate to generate antibodies for developing acne vaccines. here, we emplo ... | 2008 | 18651708 |
| biochemistry of pufa double bond isomerases producing conjugated linoleic acid. | the biotransformation of linoleic acid (la) into conjugated linoleic acid (cla) by microorganisms is a potentially useful industrial process. in most cases, however, the identities of proteins involved and the details of enzymatic activity regulation are far from clear. here we summarize available data on the reaction mechanisms of cla-producing enzymes characterized until now, from butyrivibrio fibrisolvens, lactobacillus acidophilus, ptilota filicina, and propionibacterium acnes. a general fea ... | 2008 | 18655062 |
| preoperative disinfection of the conjunctival sac with antibiotics and iodine compounds: a prospective randomized multicenter study. | to compare disinfection by povidone-iodine (pi) solution with that by polyvinyl alcohol-iodine (pai) solution in preoperative eyewash and to assess the optimal duration of the preoperative application of 0.5% levofloxacin (lvfx) ophthalmic solution. | 2008 | 18661264 |
| cbt-sl5, a bacteriocin from enterococcus faecalis, suppresses the expression of interleukin-8 induced by propionibacterium acnes in cultured human keratinocytes. | propionibacterium acnes is known to play a pivotal role in the pathogenesis of acne vulgaris. cbt-sl5 is one of the antimicrobial peptides from enterococcus faecalis sl5, and it has shown antimicrobial activity against p. acnes. the aim of this study was to investigate the anti-inflammatory effect of cbt-sl5 on the inflammation induced by p. acnes in cultured human keratinocyes. cultured human keratinocytes derived from neonatal foreskin were treated with heatkilled p. acnes to induce inflammati ... | 2008 | 18667861 |
| bacteriologic profile of the conjunctiva in the patients with dry eye. | to assess the conjunctival bacterial profiles in dry eye and their fluoroquinolone susceptibility patterns. | 2008 | 18672220 |
| monitoring the physiologic stress response: a novel biophysical approach for the rapid detection of bacteria in platelet concentrate. | currently approved culture-based methods for the bacterial testing of platelet concentrates (pcs) require an extended period of time to obtain results. a new approach based on the monitoring of the bacterial response to physiologic stress is presented. because the stress response is independent of the growth rate, decisive results can be obtained in near real time. | 2008 | 18673343 |
| value of anaerobic culture in bacterial surveillance program for platelet concentrates. | short-term aerobic bacterial culture (stabc) has been used routinely in hong kong since 1998 to reduce bacterial contamination in platelet concentrates (pcs) with good results. with more countries implementing routine aerobic and anaerobic cultures of pcs, a prospective study was conducted to determine the value of anaerobic culture to stabc. | 2008 | 18694462 |
| inducible siphoviruses in superficial and deep tissue isolates of propionibacterium acnes. | propionibacterium acnes is a commensal of human skin but is also known to be involved in certain diseases, such as acne vulgaris and infections of orthopaedic implants. treatment of these conditions is complicated by increased resistance to antibiotics and/or biofilm formation of p. acnes bacteria. p. acnes can be infected by bacteriophages, but until recently little has been known about these viruses. the aim of this study was to identify and characterize inducible phages from p. acnes on a gen ... | 2008 | 18702830 |
| antibacterial and anti-inflammatory effects of jeju medicinal plants against acne-inducing bacteria. | propionibacterium acnes and staphylococcus epidermidis are pus-forming bacteria that trigger inflammation in acne. the present study was conducted to evaluate the antimicrobial activities of jeju medicinal plants against these etiologic agents of acne vulgaris. ethanol extracts of jeju plants were tested for antimicrobial activities by disc diffusion and broth dilution methods. the results from the disc diffusion assays revealed that four medicinal plants, mollugo pentaphylla, angelica anomala, ... | 2008 | 18497484 |
| the significance of t cells, b cells, antibodies and macrophages against encephalomyocarditis (emc)-d virus-induced diabetes in mice. | in order to clarify the significance of protective mechanisms against encephalomyocarditis (emc) virus-induced diabetes in mice, we studied the relative importance of t cells, b cells, antibodies and macrophages in the prevention of virus-induced diabetes. neither t cell-deficient athymic nude mice nor b cell-deficient micromt/micromt mice showed an enhanced clinical course of emc-d virus-induced diabetes, indicating that neither t cells nor b cells played a major role in the protection against ... | 2008 | 18500429 |
| ribosomal rna-based analysis of the bacterial flora from the conjunctivae of cattle with bovine keratoconjunctivitis (bkc). | bovine keratoconjunctivitis (bkc), colloquially referred to as 'pinkeye', is a disease affecting cattle worldwide; it costs cattle producers millions of dollars in economic loss annually. while moraxella spp. are the primary etiologic agent of pinkeye, surveys of flora from the conjunctivae of livestock from around the world have indicated that a variety of bacterial commensals occupy this niche. we used molecular biology-based methods to determine the composition of bacterial flora in the conju ... | 2008 | 18513895 |
| in vitro evaluation of the effect of nicotine, cotinine, and caffeine on oral microorganisms. | the aim of this in vitro study was to evaluate the effects of nicotine, cotinine, and caffeine on the viability of some oral bacterial species. it also evaluated the ability of these bacteria to metabolize those substances. single-species biofilms of streptococcus gordonii, porphyromonas gingivalis, or fusobacterium nucleatum and dual-species biofilms of s. gordonii -- f. nucleatum and f. nucleatum -- p. gingivalis were grown on hydroxyapatite discs. seven species were studied as planktonic cell ... | 2008 | 18535638 |
| characterization of the immune response in the synovitis, acne, pustulosis, hyperostosis, osteitis (sapho) syndrome. | the aetiology of sapho (synovitis, acne, palmoplantar pustulosis, hyperostosis, osteitis) syndrome seems to involve genetic, infectious and immunological components. we examined innate and adaptive immune responses in sapho syndrome, as compared with psa and ra. we also studied the effect of etanercept on immunological parameters. | 2008 | 18559374 |
| benzoyl peroxide microsphere cream as monotherapy and combination treatment of acne. | this office-based case series describes the use of a new formulation of benzoyl peroxide (bpo) delivered via a porous microsphere cream vehicle in patients with mild to moderate acne vulgaris. while bpo has been used for many years as antimicrobial in the treatment of acne, in recent years its use has been increasingly encouraged as part of a strategy designed to reduce propionibacterium acnes (p acnes) resistance to antibiotics. historically, a major drawback to bpo treatment has been irritatio ... | 2008 | 18561594 |
| all-trans retinoic acid shifts propionibacterium acnes-induced matrix degradation expression profile toward matrix preservation in human monocytes. | propionibacterium acnes is a critical component in the pathogenesis of acne vulgaris, stimulating the production of various inflammatory mediators, such as cytokines and chemokines, important in the local inflammatory response found in acne. this study explored the role of p. acnes and its ability to induce matrix metalloproteinases (mmps) in primary human monocytes and how this induction is regulated by retinoids. mmp-1- and mmp-9-expressing cells were present in perifollicular and dermal infla ... | 2008 | 18563181 |
| role of infectious agents in systemic rheumatic diseases. | the relationship between infection and autoimmunity has been increasingly defined over the last twenty years or so. it is now quite clear that, in genetically susceptible individuals, environmental factors (mainly infections) play a critical role in the pathogenesis of autoimmune diseases. it is believed that infections contribute to the maturation of the immune system from the innate to adoptive phases, and that bacterial and viral infections are arthritogenic stimulants leading to various rheu ... | 2008 | 18570751 |
| effects of er:yag laser irradiation on biofilm-forming bacteria associated with endodontic pathogens in vitro. | with the development of dental laser delivery systems that can enter into the root canals, it is possible to use er:yag lasers to remove the residual biofilm associated with infected root canals. we examined their effects against biofilms made of actinomyces naeslundii, enterococcus faecalis, lactobacillus casei, propionibacterium acnes, fusobacterium nucleatum, porphyromonas gingivalis, or prevotella nigrescens in vitro. after er:yag laser irradiation with energy densities ranging between 0.38- ... | 2008 | 18570988 |
| topical taurine bromamine, a new candidate in the treatment of moderate inflammatory acne vulgaris: a pilot study. | taurine bromamine (taubr), the product of taurine and hypobromous acid (hobr), exerts anti-inflammatory and antibacterial properties. recently we have shown that propionibacterium acnes, a potential pathogenic agent of acne, is extremely sensitive to taubr. as topical antibiotics are associated with the emergence of resistant bacteria, taubr seems to be a good candidate for topical therapy for acne vulgaris. in our double blind investigation, the efficacy and safety of 3.5 mm taubr cream was eva ... | 2008 | 18573718 |
| azithromycin pulses in the treatment of inflammatory and pustular acne: efficacy, tolerability and safety. | azithromycin is an azalide analogous to erythromycin; it has an anti-inflammatory action that prevents the growth of propionibacterium acnes, a major microorganism involved in the pathogenesis of inflammatory acne. | 2008 | 18608737 |
| primary intraocular lymphoma: another great masquerader. | to describe diverse and atypical presentations of the most common masquerader in neoplastic masquerade syndromes. | 2008 | 18609476 |
| effect of garcinia mangostana on inflammation caused by propionibacterium acnes. | the present study was aimed to investigate the activity of thai medicinal plants on inflammation caused by propionibacterium acnes in terms of free radical scavenging and cytokine reducing properties. p. acnes have been recognized as pus-forming bacteria triggering an inflammation in acne. antioxidant activity was determined by dpph scavenging and nbt reduction assay. the result showed that garcinia mangostana possessed the most significant antioxidant activity and reduced reactive oxygen specie ... | 2007 | 17644272 |
| isomers of conjugated linoleic acids are synthesized via different mechanisms in ruminal digesta and bacteria. | digesta samples from the ovine rumen and pure ruminal bacteria were incubated with linoleic acid (la) in deuterium oxide-containing buffer to investigate the mechanisms of the formation of conjugated linoleic acids (clas). rumenic acid (ra; cis-9,trans-11-18:2), trans-9,trans-11-18:2, and trans-10,cis-12-18:2 were the major cla intermediates formed from la in ruminal digesta, with traces of trans-9,cis-11-18:2, cis-9,cis-11-18:2, and cis-10,cis-12-18:2. mass spectrometry indicated an increase in ... | 2007 | 17644775 |
| clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: focus on antibiotic resistance. | propionibacterium acnes is an anaerobic bacterium that plays an important role in the pathogenesis of acne. certain antibiotics that can inhibit p acnes colonization also have demonstrated anti-inflammatory activities in the treatment of acne, rosacea, and other noninfectious diseases. decreased sensitivity of p acnes to antibiotics, such as erythromycin and tetracycline, has developed and may be associated with therapeutic failure. benzoyl peroxide (bpo) is a nonantibiotic antibacterial agent t ... | 2007 | 17649854 |
| community-based study of acne vulgaris in adolescents in singapore. | there are few studies on the prevalence of acne vulgaris among asian teenagers. | 2007 | 17655737 |
| heterologous expression of linoleic acid isomerase from propionibacterium acnes and anti-proliferative activity of recombinant trans-10, cis-12 conjugated linoleic acid. | the linoleic acid isomerase enzyme from propionibacterium acnes responsible for bioconversion of linoleic acid to trans-10, cis-12 conjugated linoleic acid (t10, c12 cla) was cloned and overexpressed in lactococcus lactis and escherichia coli, resulting in between 30 and 50 % conversion rates of the substrate linoleic acid to t10, c12 cla. the anti-proliferative activities of the fatty acids produced following isomerization of linoleic acid by l. lactis and e. coli were assessed using the human ... | 2007 | 17660413 |
| [pulsed dye laser treatment of acne. study of clinical efficacy and mechanism of action]. | acne vulgaris is a multifactorial disease of the pilosebaceous unit characterized by the development of inflammatory (papules, pustules, cysts) and/or non inflammatory lesions (open and closed comedones) that may progress to scars. the increase of bacterial resistances, adverse effects and teratogenicity of retinoids and lack of response to usual therapies have led to investigate new therapeutic alternatives for acne. | 2007 | 17663931 |
| the propionibacterium acnes genome: from the laboratory to the clinic. | the genome of propionibacterium acnes, the microbe presumed to be at least partially etiologic for the development of acne, has recently been decoded. the genome supports long-standing concepts regarding acne pathogenesis, but also demonstrates heretofore unknown and/or unsuspected bacterial properties, which might play a role in disease occurrence. in turn, understanding the genome may lead to new therapeutic avenues, as summarized in this manuscript. | 2007 | 17668523 |
| study results of benzoyl peroxide 5%/clindamycin 1% topical gel, adapalene 0.1% gel, and use in combination for acne vulgaris. | combination therapy is the standard of care in the management of acne vulgaris. it is essential to treat as many aspects of acne pathogenesis as possible. due to increasing insensitivity of propionibacterium acnes to antibiotics, the concomitant use of other topical agents that exhibit other modes of antibacterial and anti-inflammatory activity is integral to the successful treatment of acne. the combination of topical benzoyl peroxide and clindamycin gel has been shown to be more effective than ... | 2007 | 17668527 |
| reimplantation of a glenoid component following component removal and allogenic bone-grafting. | glenoid component loosening has been a leading cause of failure of total shoulder arthroplasty. in the present study, we evaluated the outcome of reimplantation of a new glenoid component following removal of the previous glenoid component and placement of an allograft in order to determine the results, risk factors for an unsatisfactory outcome, and rate of failure associated with this procedure. | 2007 | 17671018 |
| non-cell corynebacterium parvum generated by nanotechnology: a promising immunomodulator with less side effects. | corynebacterium parvum (cp), a kind of immunomodulator, has been well documented in immunotherapy to tumor. however, severe side effects, such as intrahepatic granulomas and scleromas in injected areas, restrict its clinical application. to minimize side effects of cp, a non-cell corynebacterium parvum product (ncpp) was prepared by disposing cp with nanotechnology. in present study, we compared effect of ncpp with that of cp and found: (1) ncpp with non-formaldehyde residue was easy to be absor ... | 2007 | 17673148 |
| modulation of integrins and filaggrin expression by propionibacterium acnes extracts on keratinocytes. | propionibacterium acnes plays an important role in the pathogenesis of acne and it is established that this bacteria is involved in the induction and maintenance of the inflammatory phase of acne. the aim of our work was to determine if p. acnes extracts could modulate integrins and filaggrin in vitro expression by keratinocytes. integrins and filaggrin expression was examined using immunohistochemistry technique both on normal human epiderminal keratinocytes (nhek) and on deep-frozen sections o ... | 2007 | 17684752 |
| comparison of azithromycin and moxifloxacin against bacterial isolates causing conjunctivitis. | to examine in vitro resistance to azithromycin and moxifloxacin in bacterial conjunctivitis isolates. | 2007 | 17688706 |
| propionibacterium acnes acts as an adjuvant in in vitro immunization of human peripheral blood mononuclear cells. | we have established an in vitro immunization protocol whereby human peripheral blood mononuclear cells (pbmcs) are initially treated with l-leucyl-l-leucine methyl ester (llme) and subsequently sensitized with antigen in the presence of interleukin (il)-2, il-4, and adjuvant. this protocol resulted in the production of antigen-specific antibodies. pbmcs are potentiated to react with exogenous antigens upon treatment with llme. we are using this system to investigate the immunomodulatory activity ... | 2007 | 17690460 |
| propionibacterium acnes endocarditis in an adolescent boy suffering from a congenital cardiopathy. | propionibacterium acnes endocarditis is an uncommon infection in pediatrics. we describe a case of p. acnes endocarditis in a 16-year-old boy that occurred 6 months after recurrent surgery for a congenital cardiopathy. molecular identification of p. acnes was obtained. he recovered from this infection after a surgical treatment and with a prolonged antibiotic regimen including ceftriaxone. | 2007 | 17721389 |
| acne and risk of prostate cancer. | in a recent study, prostatectomy specimens from which propionibacterium acnes was cultured were more likely to have inflammation than culture-negative specimens or specimens positive for other bacteria, leading the authors to hypothesize that p. acnes-mediated inflammation may contribute to prostate carcinogenesis. to indirectly explore associations between p. acnes and prostate cancer, we investigated severe acne, as measured by tetracycline use for 4 or more years, in relation to incident pros ... | 2007 | 17724724 |
| microcalorimetry: a novel method for detection of microbial contamination in platelet products. | measuring heat from replicating microorganisms in culture may be a rapid, accurate, and simple screening method for platelets (plts). microcalorimetry for detection of microorganisms in in vitro contaminated plt products was evaluated. | 2007 | 17725729 |
| combination of a new radiofrequency device and blue light for the treatment of acne vulgaris. | acne vulgaris is the most common skin disease treated by physicians. current topical and oral treatments may have short- and long-term negative consequences. since radiofrequency (rf) energy has been shown to reduce sebum production and 410-nm blue light has been shown to kill propionibacterium acnes (p. acnes) cells, these modalities in combination should be a highly effective treatment of acne vulgaris with little or no downtime or risk. this case report describes the efficacy and safety of rf ... | 2007 | 17763617 |
| microbial contamination of bm products before and after processing: a report of incidence and immediate adverse events in 257 grafts. | the incidence and potential clinical consequences of bacterial contamination of autologous and allogeneic bm products remains open to question. we report our experience of bacterial contamination of bm grafts and adverse events that occurred after transplantation. | 2007 | 17786612 |
| the impact and importance of resistance. | bacterial resistance to antibiotics began to emerge soon after their introduction. beginning in the 1970s, propionibacterium acnes also began to show decreased sensitivity to the antibiotics typically used in acne management. clinically, this trend has translated to decreased efficacy and even nonresponse to therapy. a variety of recommendations regarding optimum use of antibiotics in acne management have been developed to preserve the utility of these drugs. most important is the use of combina ... | 2007 | 17824580 |
| community-based trial results of combination clindamycin 1%--benzoyl peroxide 5% topical gel plus tretinoin microsphere gel 0.04% or 0.1% or adapalene gel 0.1% in the treatment of moderate to severe acne. | acne is characterized by different types of lesions at different stages of development. therefore, combination therapy may offer numerous advantages, including enhanced efficacy and better tolerability. the addition of benzoyl peroxide (bpo) to all long-term antibiotic treatment is widely advocated to help suppress the emergence of antibiotic-resistant bacteria. topical retinoids are recommended as early initiation treatment of most patients with acne because they target most mechanisms of acne ... | 2007 | 17824581 |