Publications

pseudorabies virus associated with abortion in swine.		1978	203566
virus isolation and immune responses in susceptible swine exposed with pseudorabies virus (shope strain).	eighteen seronegative swine weighing from 9 to 11 kg were exposed intranasally with the shope strain of pseudorabies virus (prv) and were observed for 21 days in an experiment to detect virus shedding and immune responses. all swine had prv in their nasal passages at 7 days after exposure; they also had precipitating antibodies to prv as determined by the microimmunodiffusion test (midt) and very low levels of virus-neutralizing (vn) antibodies. the prv was isolated from only 2 swine at postexpo ...	1978	211884
immune responses in swine given lipid-conjugated pseudorabies viral antigens.	the immune response was compared in pigs given inactivated pseudorabies virus (prv) antigens (with or without adjuvant) or prv antigens covalently conjugated with a fatty acid (lauric acid) to enhance delayed-type hypersensitivity. the pigs were given 2 inoculations, 14 days apart, and were challenge exposed 28 days after the 1st inoculation. pibs inoculated with prv antigens, with or without adjuvant, had significant virus-neutralizing (vn) antibodies before challenge exposure, but the pigs ino ...	1978	211887
[immune response of pigs to aujeszky disease virus and swine influenza virus].	explored was the possibility of simultaneous vaccination of pigs against the aujeszky's disease virus and the swine influenza virus. used were strain mk-25 against the former and strain 3sb against the latter. it was found that at the simultaneous subcutaneous or oral treatment with the two antigens equally effective immunity was built as in the case of vaccination with each one of them used alone. no antagonism was established between the two antigens during the time of immunity building in the ...	1978	214936
comparison of pseudorabies virus inactivated by bromo-ethylene-imine, 60co irradiation, and acridine dye in immune assay systems.	pseudorabies virus infections among animals, especially swine, have become prevalent in the united states in the past few years. the disease in swine is now economically important. test systems and antigens are being developed for use in control and disease suppression efforts. pseudorabies virus was inactivated by three methods: chemically, with bromo-ethylene-imine; physically, with 60co irradiation; and chemically and physically, with 3,9-diaminoacridine dye followed by exposure to white visi ...	1978	215603
immunological experimental arthritis in pigs. iii. inflammatory reactions in the brain of pigs immunized with the attenuated virus of aujeszky's disease.	histopathological brains and spinal cords of pigs were examined at different times of immunization with the virus of aujeszky's disease (ad). temporary inflammatory reaction was found to have the features of non-suppurative disseminated inflammation in the second week after the second virus dose had been given. perivascular and subependymal lymphocytic infiltrations were observed and the focal multiplication of microglia.	1978	219812
immunological experimental arthritis in pigs. iv. reaction of the synovial membrane of the non-immunized and immunized pigs after intraarticular administration of the virus of aujeszky's disease.	7 days after intramuscular administration of the attenuated virus of aujeszky's disease, strain tk 300 l, it was found: in non-immunized animals--immunological arthritis with fibrinoid necrosis and abundant infiltrations from lymphoid cells; in animals of low antibodies titer--only few infiltrations from lymphoid and plasmic cells round the sub-synovial vessels; in animals of high antibodies titer--vast areas of fibrinoid necrosis, abundant infiltrations from lymphoid cells and presence of gigan ...	1978	219813
[virus-neutralizing antibodies in the colostrum and milk of brood sows vaccinated with an ethanol vaccine against aujeszky's disease virus].	the experiment was carried out with five pregnant sows vaccinated with an etanol vaccine against the aujeszky's disease virus. studies was the level of virus-neutralizing antibodies in the blood, colostrum and milk serum of the sows as in the serum of their piglets. virus-neutralizing antibodies were contained in high titers both in the blood, colostrum, and milk serum of the sows and in the serum of the offsprings. the titer of the passively acquired antibodies in the blood serum of the sucklin ...	1977	204104
immunoglobulin classes of antibodies in milk of swine after intranasal exposure to pseudorabies virus or transmissible gastroenteritis virus.	experiments were conducted to evaluate whether infection of the respiratory tract of pregnant swine with pseudorabies (pr) virus would induce the secretion of immunoglobulin a (iga) antibodies in their milk as was observed after enteric infection with transmissible gastroenteritis (tge) virus. the immune response of sows to pr virus inoculated intranasally and to tge virus inoculated orally/intranasally or via a natural infection was studied. emphasis was placed upon titers and ig classes of pr ...	1977	197014
[studies of the cft in the diagnosis of aujeszky's disease virus in swine].	it was found that the complement-fixation test is a prompt and suitable method in the diagnosis of the aujeszky's disease virus, the antigen employed being a cell culture virus. a virulent virus, a slightly virulent one, and the vaccinal mutant strain mk have shown a good complement-fixing activity and they detect specific complement-fixing antibodies in the immune serum. by means of cross cft an antigenic relation has been established between some strains of the herpes group and the aujeszky's ...	1977	199985
[use of the plaque method for isolating aujeszky's disease virus from meat, organs and meat products].	comparative virologic studies were carried out to isolate the virus of aujesky's disease from meat, viscera, and raw smoked products by the plaque method as modified by sullivan and read as well as by the method with which the presence of the virus is recorded visually by the cytopathic effect observed in the infected cell monolayer. it was found that at the veterinary and sanitary inspection of meat and meat products produced from diseases or survived animals the modified plaque method proved m ...	1977	202066
comparative susceptibility of rabbits, rats, mice and pigs to infection with aujeszky diseases virus (adv) in the development of an efficacy test for adv vaccines.		1977	202116
influence of deae dextran upon pig lymphocyte stimulation by aujeszky disease virus antigen.		1977	203145
latent pseudorabies virus infection in pigs.	latent infection with the top strain of pseudorabies virus (prv) was established in 6 weeks old piglets. infectious virus was found in oropharyngeal swabs till day 10 post infection (p.i.); later on, attempts to detect the virus remained unsuccessful. however, prv could be isolated by explantation of tonsils, cervical lymph nodes, nasal mucosa and gasserian ganglia. these tissues were removed between 160 and 181 days p.i., during cultivation, infectious prv was released into the culture fluid fr ...	1976	9801
a comparative examination of swine sera for antibody to aujeszky virus with the conventional and a modified virus-serum neutralization test and a modified direct complement fixation test.		1976	181975
demonstration of a herpesvirus from piglets with lesions of aujeszky's disease in new zealand.		1976	189261
studies on immunity to aujeszky's disease (pseudorabies) virus infection in pigs.	aujeszky's disease is primarily a disease of pigs caused by a herpesvirus. in pigs, the primary site of virus replication is the nasopharynx. some strains cause lesions only in the central nervous system, others cause rhinitis, pneumonia and encephalitis. colostrum from immune sows protected 3 day old piglets from experimental infection, but did not prevent the piglets excreting virus. colostral antibodies were 11-16-fold greater than the serum titres in the sows and the half life of passiveanti ...	1975	165131
[role of the virus of aujeszky's disease in respiratory diseases of swine].	studies carried out on pig-breeding farms have established the presence of aujeszky's disease virus in cases of bronchopneumonia in pigs. on seven out of eight farms with bronchopneumonia the virus wad demonstrated both virologically and serologically, and nearly 50 per cent of the examined diseased pigs on these and other farms had antibodies. the individual serologic studies of pigs having antibodies revealed that the antibodies appeared in the second month of the animals' fattening. this corr ...	1975	171824
[suitability of immune serums from different animal species for the preparation of conjugates against aujeszky's disease virus].	a comparison was made of immune serum from rabbits, sheeps, pigs and cattle. pure igg was prepared by the rivanol sulphate method and immune electrophoresis. optimum protein quality, conjugation time under various conditions and using two preparations of fluorescein isothiocyanate were studied. conjugate purified by deae-sephadex a-50 and concentrated to 1% protein by ultrafiltration was freeze-dried and then tested for activity and the degree of non-specific fluorescence. evaluation by yield of ...	1975	172039
[use of temperature, trypsin and biological tests for the intraspecies differentiation of local strains of aujeszky's disease virus].	studies were carried out with 8 strains of aujeszky's disease virus using a temperature test (50 degrees c for 1 hour), a trypsin test (0.5 mg per cu. cm at 37 degrees c 1 hour), and a biologic test. the strains were isolated from the brain of dead pigs that have presumably been affected with encephalitis. they proved sensitive when studied with the temperature and the trypsin tests sharply lowering their titer. the viruses isolated from pneumonic foci in the lungs of pigs in which the disease h ...	1975	179192
inhibition of herpes virus-induced cell fusion by concanavalin a, antisera, and 2-deoxy-d-glucose.	pseudorabies virus-induced cell fusion in rabbit kidney cells can be prevented by concanavalin a added early after infection. the infected cells are not agglutinated and the infectivity of cell-free virus is not reduced. sera from productively infected animals also inhibit polykaryocytosis, whereas a hyperimmune serum directed against virus structural components has no effect. 2-deoxy-d-glucose reversibly disturbs virus-induced fusion and reduces significantly the virus infectivity.	1974	4858786
biological properties of aujeszky's disease (pseudorabies) virus strains with special regard to interferon production and interferon sensitivity.		1974	4837359
the effect of colostrum derived antibody on mortality and virus excretion following experimental infection of piglets with aujeszky's disease virus.		1973	4803575
the histopathology of experimental pneumonia in pigs produced by aujeszky's disease virus.		1973	4375835
ultrastructural changes in the lungs of pigs infected with aujeszky's disease virus.		1973	4375836
swine interferon. i. induction in porcine cell cultures with viral and synthetic inducers.	the production of interferon by porcine kidney (pk(15)) cell culture in response to viral and synthetic inducers was studied. the inducers used included a synthetic double-stranded polyribonucleotide, polyriboinosinic-polyribocytidylic acid (poly i:c), swine influenza virus and three strains of pseudorabies virus. following exposure to these inducers cell culture fluids were examined for interferon by the plaque-reduction method. the poly i:c and the swine influenza virus induced production of i ...	1972	4340345
[viability of the buk vaccine strain of aujeszky's disease virus in the aerosol state].		1970	5421600
resistance of pig tonsillary and throat mucosa to reinfection with a homologous pseudorabies virus strain.		1970	4392072
pseudorabies virus with lost virulence for rabbits after intra-muscular inoculation, obtained from persistently infected cell cultures.		1968	4385165
properties of aujeszky's disease virus strains isolated from swine pneumonia cases. prelininary report.		1968	4298985