Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| novel anti-metastatic action of cidofovir mediated by inhibition of e6/e7, cxcr4 and rho/rock signaling in hpv tumor cells. | cervical cancer is frequently associated with hpv infection. the expression of e6 and e7 hpv oncoproteins is a key factor in its carcinogenicity and might also influence its virulence, including metastatic conversion. the cellular mechanisms involved in metastatic spread remain elusive, but pro-adhesive receptors and their ligands, such as sdf-1alpha and cxcr4 are implicated. in the present study, we assessed the possible relationship between sdf-1alpha/cxcr4 signaling, e6/e7 status and the meta ... | 2009 | 19325708 |
| cancer risk in persons with hiv/aids in india: a review and future directions for research. | india has a large and evolving hiv epidemic. little is known about cancer risk in indian persons with hiv/aids (pha) but risk is thought to be low. | 2009 | 19327166 |
| infectious complications in three double hand recipients: experience from a single center. | composite tissue allograft (cta) recipients require high level of immunosuppression and, therefore, are at significant risk to acquire opportunistic infections. | 2009 | 19328916 |
| incidence of human papillomavirus (hpv) positive tonsillar carcinoma in stockholm, sweden: an epidemic of viral-induced carcinoma? | in the county of stockholm, between 1970 and 2002, we have previously reported a 3-fold parallel increase in the incidence of tonsillar squamous cell carcinoma (scc) and the proportion of human papillomavirus (hpv) positive tonsillar scc. here, we have followed the above parameters in all patients (n = 120) diagnosed with tonsillar scc during 2003-2007 in the same area, and also in correlation to our previous data. ninety-eight pretreatment biopsies were available and presence of hpv dna and hpv ... | 2009 | 19330833 |
| galectin-3 overexpression in invasive laryngeal carcinoma, assessed by computer-assisted analysis. | the larynx is the most common site of malignancy in the upper aerodigestive tract. in brazil, malignant laryngeal lesions represent 2% of all cancers, with approximately 3000 annual deaths. the association between human papillomavirus (hpv) and laryngeal cancer is still controversial. the aim of the present retrospective study was to determine the expression of galectin-3 immunoperoxidase in laryngeal carcinoma by examining paraffin-embedded larynx biopsies from 65 patients, 10 in situ laryngeal ... | 2009 | 19332433 |
| cervical carcinoma and sexual behavior: collaborative reanalysis of individual data on 15,461 women with cervical carcinoma and 29,164 women without cervical carcinoma from 21 epidemiological studies. | high-risk human papillomavirus (hpv) types cause most cervical carcinomas and are sexually transmitted. sexual behavior therefore affects hpv exposure and its cancer sequelae. the international collaboration of epidemiological studies of cervical cancer has combined data on lifetime number of sexual partners and age at first sexual intercourse from 21 studies, or groups of studies, including 10,773 women with invasive cervical carcinoma, 4,688 women with cervical intraepithelial neoplasia grade ... | 2009 | 19336546 |
| [polish gynaecological society guidelines for human papilloma virus (hpv) vaccination]. | 2009 | 19338212 | |
| human papillomavirus-related disease in people with hiv. | the incidence of human papillomavirus (hpv)-related cancers has increased among people with hiv infection compared with the general population. this review will describe recent findings in hpv-associated cancer incidence since the introduction of antiretroviral therapy, hpv/disease prevalence at sites other than cervix and anus, and recent data on screening and treatment of anal intraepithelial neoplasia. | 2009 | 19339939 |
| somatic lkb1 mutations promote cervical cancer progression. | human papilloma virus (hpv) is the etiologic agent for cervical cancer. yet, infection with hpv is not sufficient to cause cervical cancer, because most infected women develop transient epithelial dysplasias that spontaneously regress. progression to invasive cancer has been attributed to diverse host factors such as immune or hormonal status, as no recurrent genetic alterations have been identified in cervical cancers. thus, the pressing question as to the biological basis of cervical cancer pr ... | 2009 | 19340305 |
| a highly efficient system to produce infectious human papillomavirus: elucidation of natural virus-host interactions. | a simple, efficient system has been developed to produce high titers of infectious human papillomavirus type 18 (hpv-18) in organotypic raft cultures of primary human keratinocytes (phks). molecular characterization elucidated key early and late events in the reproductive program. the system obviates the need for immortalized cells and allows the analyses of mutant hpv genomes not previously possible. an e6 deletion mutant incapable of causing p53 degradation is defective in viral dna amplificat ... | 2009 | 19342877 |
| anal cancer screening in men who have sex with men. | to determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. | 2009 | 19343830 |
| role of human papillomavirus in the clinical and histopathologic features of laryngeal and hypopharyngeal cancers. | in this study, we aimed to evaluate the role of human papillomavirus (hpv) in the clinical and histopathologic features of laryngeal and hypopharyngeal cancers. | 2009 | 19344621 |
| the epidemiology of anal human papillomavirus and related neoplasia. | the relationship between cervical cancer and human papillomavirus (hpv) is well known. like cervical cancer, anal cancer is preceded by a series of precancerous changes, raising the possibility that like cervical cancer, anal cancer can be prevented. further, given the known risk factors for anal cancer, prevention efforts could be targeted to high-risk groups, providing a unique example of a screening program targeted to high-risk individuals. this article describes the epidemiology of anal hpv ... | 2009 | 19344856 |
| mechanisms of decreased expression of transforming growth factor-beta receptor type i at late stages of hpv16-mediated transformation. | transforming growth factor-beta (tgf-beta) signaling is disrupted in many cancers, including cervical cancer, leading to tgf-beta resistance. although initially sensitive, human papillomavirus type 16 (hpv16) immortalized human keratinocytes (hkc/hpv16) become increasingly resistant to the growth inhibitory effects of tgf-beta during in vitro progression to a differentiation resistant phenotype (hkc/dr). we have previously shown that loss of tgf-beta sensitivity in hkc/dr is attributed to decrea ... | 2009 | 19344999 |
| adolescent girls' attitudes on human papillomavirus vaccination. | the objective of the study was to assess the attitudes of adolescent girls on human papillomavirus (hpv) vaccination and the impact of an information pamphlet on their attitude. other factors that may affect their attitude were also studied. | 2009 | 19345913 |
| genetic variation in the vitamin c transporter, slc23a2, modifies the risk of hpv16-associated head and neck cancer. | human papillomavirus (hpv) type 16 infection is an etiologic factor in a subset of head and neck squamous cell carcinomas (hnscc). it is unknown if host genetic susceptibility modifies the hpv16-hnscc association. dna samples collected as part of a boston area case-control study of hnscc were genotyped for single-nucleotide polymorphisms (snps) from the national cancer institute's snp500cancer database. analysis of demographic, phenotypic and genotypic data for 319 hnscc cases and 495 frequency- ... | 2009 | 19346260 |
| role of molecular markers and gene profiling in head and neck cancers. | to explore the current status of molecular markers in the diagnosis, prognosis, and treatment of squamous cell carcinoma of the head and neck. | 2009 | 19346943 |
| geographic variation in the prevalence of kaposi sarcoma-associated herpesvirus and risk factors for transmission. | the aim of the present study was to estimate the prevalence of kaposi sarcoma-associated herpesvirus (kshv) in the female general population, to define geographic variation in and heterosexual transmission of the virus. | 2009 | 19351262 |
| cost-effectiveness evaluation of a quadrivalent human papillomavirus vaccine in belgium. | the introduction of a quadrivalent human papillomavirus (hpv; types 6, 11, 16, 18) vaccine is expected to significantly reduce the burden of cervical cancer, cervical intraepithelial neoplasia (cin), genital warts and other hpv-related diseases. | 2009 | 19354343 |
| molecular tests for human papillomavirus (hpv), chlamydia trachomatis and neisseria gonorrhoeae in liquid-based cytology specimen. | laboratory detection of human papillomavirus (hpv), chlamydia trachomatis and neisseria gonorrhoeae in liquid-based cervicovaginal cytology specimens is now based on identification of the dna sequences unique to these infectious agents. however, current commercial test kits rely on nucleotide probe hybridization to determine dna sequences, which may lead to diagnostic errors due to cross-reactivity. the aim of this study was to find a practical approach to perform automated sanger dna sequencing ... | 2009 | 19358733 |
| human papillomavirus 58 in a squamous cell carcinoma of the tongue. | 2009 | 19362048 | |
| cost-effectiveness of human papillomavirus vaccination in belgium: do not forget about cervical cancer screening. | the cost-effectiveness of adding a human papillomavirus (hpv) vaccination program in 12-year-old females to the recommended cervical cancer screening in belgium is examined. moreover, the health and economic consequences of a potential decline in screening uptake after initiation of a hpv vaccination program are investigated. | 2009 | 19366497 |
| potent anti-hpv immune responses induced by tandem repeats of the hpv16 l2 (20 -- 38) peptide displayed on bacterial thioredoxin. | the minor capsid protein l2 is a promising candidate for the construction of an anti-human papillomavirus (hpv) broadly protective vaccine for the prophylaxis of cervical cancer. however, l2-derived peptides are usually poorly immunogenic and extensive knowledge on the most relevant (cross)neutralizing epitope(s) is still needed. we systematically examined the immunogenicity and virus neutralization potential of six peptides encompassing the n-terminal (amino acids 1 -- 120) region of hpv16 l2 ( ... | 2009 | 19368776 |
| usefulness of p16 for differentiating primary pulmonary squamous cell carcinoma from cervical squamous cell carcinoma metastatic to the lung. | to date, there is no reliable immunohistochemical marker that discriminates between primary pulmonary squamous cell carcinoma (scc) and cervical scc metastatic to the lung. in this study, immunohistochemical staining of p16 was performed on 33 primary pulmonary sccs, 48 primary cervical sccs, and 17 cases of cervical scc with pulmonary metastasis. expression of p16 was noted in 47 cases of cervical scc (47/48 [98%]), and all were strongly stained. of the 7 cases of primary pulmonary scc (7/33 [2 ... | 2009 | 19369633 |
| papanicolaou screening behavior in mothers and human papillomavirus vaccine uptake in adolescent girls. | we investigated whether maternal attitude toward prevention, as indicated by history of seeking papanicolaou (pap) tests and contracting sexually transmitted infections, influenced human papillomavirus (hpv) vaccine uptake among their adolescent daughters. | 2009 | 19372507 |
| p16 ink4a is a strong biomarker for cervical intraepithelial neoplasia and invasive cervical carcinoma: a reappraisal. | to assess the role of p16( ink4a), bcl-2, and p53 in cervical cancer screening, we conducted a retrospective trial of prospectively collected data. sixty two women with abnormal pap smears were subjected to colposcopy and biopsies from any abnormal lesion. human papillomavirus (hpv)-dna typing, histology, and immunochemistry for p16(ink4a), bcl-2, and p53 were performed for these women. histologic diagnosis was that of low grade squamous intraepithelial lesion (lsil), high grade squamous intraep ... | 2009 | 19372590 |
| adverse events and quadrivalent human papillomavirus recombinant vaccine. | 2009 | 20040547 | |
| marketing and the hpv vaccine. | 2009 | 20040550 | |
| [preparation and identification of type specific and conformation dependent hpv16 l1 protein monoclonal antibody.]. | to generate type specific and conformation dependent monoclonal antibodies against human papillomavirus 16 major capsid l1 protein (hpv16 l1). | 2009 | 19961800 |
| the role of human papillomavirus testing in cervical cancer screening. | 2009 | 19999172 | |
| [expression of gelatinases a and b and their endogenous regulators in immortal and transformed fibroblasts]. | matrix metalloproteinases (mmp) play a critical role in tumor invasion and metastasis. the aim of this study was to elucidate peculiarity of expression of gelatinases a and b (mmp-2 and mmp-9), membrane type mmp (mt1-mmp) and tissue inhibitor of mmp (timp-2) in immortal (if) and transformed fibroblasts (tf).the study was carried out using embryo rat fibroblasts, sequentially immortalized with the polyomavirus lt gene and transformed with the e7 gene of human papilloma virus (hpv-16). papilloma v ... | 2009 | 20000122 |
| should boys receive the human papillomavirus vaccine? yes. | 2009 | 19969602 | |
| human papilloma virus and female lung adenocarcinoma. | lung cancer is the leading cause of cancer among women worldwide, and adenocarcinoma is the most common histological subtype among non-smoking women. previous studies showed that human papillomavirus (hpv) infection may relate to the tumorigenesis of pulmonary adenocarcinoma. women with anogenital malignancy have a higher risk of lung cancer, which raises the possibility of hpv transmission from the cervix to the lung. two postulated pathways are discussed in this work. first, hpv may infect the ... | 2009 | 19995646 |
| bowen's disease of the nail matrix presenting as melanonychia: detection of human papillomavirus type 56. | 2009 | 19997699 | |
| [effect of hpv16e6 on sensitivity of chemotherapy for cervical carcinoma in different p53 genotype cell lines]. | to investigate the effect of human papillomavirus types 16e6 on the sensitivity of chemotherapy for cervical carcinoma in different p53 genotype cell lines. | 2009 | 19952400 |
| annual disease burden due to human papillomavirus 16 and 18 infections in finland. | apart from cancers of the lower female genital tract, human papillomaviruses (hpv) are associated with a large number of benign, premalignant and malignant lesions at different anatomic sites in both genders. malignant tumours and their precursors are usually attributed to the oncogenic (high-risk, hr) hpv types, whereas benign lesions (mostly papillomas) are ascribed to the low-risk (lr) hpv types, most notably hpv6 and hpv11. to date, the main interest has been focused on hr-hpv types and thei ... | 2009 | 19939209 |
| persistent antibodies to hpv virus-like particles following natural infection are protective against subsequent cervicovaginal infection with related and unrelated hpv. | whether persistent human papillomavirus (hpv) igg antibodies following natural infection are protective against subsequent infection is unknown. in a cohort of 508 college women followed for 3 y, persistent seropositivity was defined as the presence of type-specific hpv virus-like particle (vlp) antibodies at > or = 2 consecutive visits 1 y apart. protection from incident infection with any hpv was conferred by persistent antibodies to hpv16 (p = 0.02), hpv31 (p < 0.001), hpv33 (p = 0.03), hpv35 ... | 2009 | 19951181 |
| adherence to cervical cancer screening guidelines for u.s. women aged 25-64: data from the 2005 health information national trends survey (hints). | although it is widely accepted that papanicolaou (pap) screening can reduce cervical cancer mortality, many women still do not maintain regular cervical cancer screenings. | 2009 | 19951209 |
| hpv vaccine acceptance among latina mothers by hpv status. | we investigated whether latina mothers who were and were not human papillomavirus (hpv) positive differed in their knowledge and acceptance of the hpv vaccine for their children. | 2009 | 19951213 |
| currently approved prophylactic hpv vaccines. | cervarix and gardasil are two prophylactic hpv vaccines designed primarily for cervical cancer prevention. cervarix is effective against hpv-16, -18, -31, -33 and -45, the five most common cancer-causing types, including most causes of adenocarcinoma for which we cannot screen adequately. gardasil is effective against hpv-16, 18 and 31, three common squamous cell cancer-causing types. in addition, gardasil is effective against hpv-6 and -11, causes of genital warts and respiratory papillomatosis ... | 2009 | 19943762 |
| causes of oral cancer--an appraisal of controversies. | major risk factors for oral cancer are cigarette smoking and alcohol misuse. among asian populations, regular use of betel quid (with or without added tobacco) increases oral cancer risks. dentists should be aware of some emerging risk factors for oral, and particularly oropharyngeal cancer such as the role of the human papillomavirus infection (hpv). decreases in risk could be achieved by encouraging high fruit and vegetable consumption. some controversies related to the aetiology of this disea ... | 2009 | 19946320 |
| assessing knowledge of human papillomavirus and collecting data on sexual behavior: computer assisted telephone versus face to face interviews. | education campaigns seeking to raise awareness of human papillomavirus (hpv) and promoting hpv vaccination depend on accurate surveys of public awareness and knowledge of hpv and related sexual behavior. however, the most recent population-based studies have relied largely on computer-assisted telephone interviews (cati) as opposed to face to face interviews (ftfi). it is currently unknown how these survey modes differ, and in particular whether they attract similar demographics and therefore le ... | 2009 | 19930668 |
| prevalence of sexually transmitted infections among female adolescents aged 14 to 19 in the united states. | most young women initiate sexual activity during adolescence; risk for sexually transmitted infections (stis) accompanies this initiation. in this study we estimated the prevalence of the most common stis among a representative sample of female adolescents in the united states. | 2009 | 19933728 |
| update on quadrivalent human papillomavirus vaccination and pregnancy outcomes: is contraception advisable? | 2009 | 19935015 | |
| hpv vaccine protein l1 predicts disease outcome of high-risk hpv+ early squamous dysplastic lesions. | prediction of the clinical outcome of nonadvanced, early dysplastic lesions is one of the unresolved problems of cervical cancer screening programs. we examined the influence of human papillomavirus (hpv) l1 capsid protein detection in a randomized, prospective study of 187 high-risk hpv+ early dysplastic lesions during 36 to 46 months. the difference in the clinical outcome of the hpv l1- cases and the hpv l1+ cases was highly statistically significant (p < .0001) and independent of the classif ... | 2009 | 19926574 |
| age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting. | human papillomavirus (hpv) dna testing has shown higher sensitivity than cytology for detecting cervical lesions, but it is uncertain whether the higher sensitivity is dependent on the age of the woman being screened. we compared the age-specific performance of primary hpv dna screening with that of conventional cytology screening in the setting of an organized population-based cervical cancer screening program in finland. | 2009 | 19903804 |
| a 25-year analysis of veterans treated for tonsillar squamous cell carcinoma. | to determine the recurrence and survival outcome based on treatment date, type of treatment, stage of disease, and comorbidity and the recurrence and survival differences based on smoking status as a surrogate for human papillomavirus status in veterans treated for tonsillar squamous cell carcinoma (scc). | 2009 | 19917929 |
| formation of 8-nitroguanine, a nitrative dna lesion, in inflammation-related carcinogenesis and its significance. | chronic infection and inflammation contribute to a substantial part of environmental carcinogenesis. recently, it has been estimated that chronic inflammation accounts for approximately 25% of cancer cases. various infectious diseases and physical, chemical, and immunological factors participate in inflammation-related carcinogenesis. under inflammatory conditions, reactive oxygen and nitrogen species, which are generated from inflammatory and epithelial cells, may play an important role in carc ... | 2009 | 19921494 |
| no evidence for a pathogenic role of human papillomavirus infection in ocular surface squamous neoplasia in germany. | the etiology of ocular surface squamous neoplasia is unknown. possible etiologic factors are physical and/or viral damage by human papillomavirus (hpv), especially in sub-saharian populations. this study focused on the presence of human papillomavirus in ocular surface squamous neoplasia in comparison to pterygia and normal conjunctiva. | 2009 | 19899994 |
| production of immunogenic human papillomavirus-16 major capsid protein derived virus like particles. | recombinant dna technology allows expression of the human papillomavirus (hpv) major capsid protein (l1) in heterologous expression systems and the recombinant protein self assembles to virus-like particles (vlp). we took up this study to produce recombinant hpv-16 l1 in yeast, establish the process of recombinant l1 derived vlp preparation and develop an elisa using vlp as the antigen for serological evaluation of anti hpv-16 l1 antibody status. | 2009 | 19901429 |
| infection of human papillomaviruses in cancers of different human organ sites. | clinico-epidemiological and molecular studies have established the casual link between human papillomavirus (hpv) infection and cervical cancer as also association of hpv infection with several other cancers. in india, cervical cancer is a leading cancer among women and almost all cases of cervical cancer show prevalence of high risk (hr)-hpv infection. hpv has been also detected in a significant proportion of oral, esophageal, anal, vaginal, vulvar, and penile cancer and in a small percentage o ... | 2009 | 19901431 |
| human papillomavirus infection (hpv) & screening strategies for cervical cancer. | the incidence of cervical cancer is declining slowly necessitating concerted and organized control measures. control through primary prevention has become a distinct reality though a prophylactic vaccine, which may take quite some time for its widespread use. thus control of cervical cancer through secondary preventive measures is the only viable solution now. while high quality cytology screening may not be feasible for widescale implementation in developing countries because of lack of necessa ... | 2009 | 19901432 |
| genotypes of the human papillomavirus: relevance to indian field trials of the vaccine. | highly effective hpv vaccines are likely to become available for use in india shortly. the availability and validation of the vaccines to prevent oncogenic hpv infection associated lesions from progressing to cancer has clearly offered a cost effective long-term strategy to reduce the cervical cancer burden, particularly for developing countries where effective screening programmes are not available. the enthusiasm for these new vaccines duly justified, are we in reality targeting the actual del ... | 2009 | 19901434 |
| human papillomavirus infection, cancer & therapy. | infection with human papillomaviruses (hpvs) is a major public health burden worldwide and is associated with a variety of epithelial lesions, including benign warts and several types of anogenital tumours, particularly cervical carcinoma. from available data it is clear that members of the hpv family are important human pathogens. prevention or elimination of these infections would not only benefit the numerous patients with benign lesions, but ultimately should reduce the incidence of cervical ... | 2009 | 19901437 |
| human papillomavirus vaccines: current issues & future. | cervical cancer is the leading cause of cancer mortality among women in worldwide. some 99 per cent of cervical cancer cases are linked to genital infection with human papillomaviruses (hpvs) comprised of approximately 15 oncogenic genital hpv types. most hpv infections resolve spontaneously. but, the remainder persist and may then progress to cervical cancer in some women. in high-resource countries, the best way to prevent cervical cancer is to implement organised gynaecological screening prog ... | 2009 | 19901444 |
| development of a soluble ptd-hpv18e7 fusion protein and its functional characterization in eukaryotic cells. | though accumulated evidence has demonstrated the transformation capacity of human papillomavirus (hpv) type 18 protein e7, the underlying mechanism is still arguable. developing a protein transduction domain (ptd)-linked e7 molecule is a suitable strategy for assessing the biological functions of the protein. in the present study, hpv18 e7 protein fused to an n-terminal ptd was expressed in the form of glutathione s-transferase fusion protein in escherichia coli with pgex-4t- 3 vector. after glu ... | 2009 | 19902124 |
| artistic: a randomised trial of human papillomavirus (hpv) testing in primary cervical screening. | primary cervical screening uses cytology to detect cancer precursor lesions [cervical intraepithelial neoplasia stage 3 or beyond (cin3+)]. human papillomavirus (hpv) testing could add sensitivity as an adjunct to cytology or as a first test, reserving cytology for hpv-positive women. this study addresses the questions: does the combination of cytology and hpv testing achieve a reduction in incident cin3+?; is hpv testing cost-effective in primary cervical screening?; is its use associated with ... | 2009 | 19891902 |
| viral entry mechanisms: human papillomavirus and a long journey from extracellular matrix to the nucleus. | papillomaviruses are epitheliotropic non-enveloped double-stranded dna viruses, whose replication is strictly dependent on the terminally differentiating tissue of the epidermis. they induce self-limiting benign tumors of skin and mucosa, which may progress to malignancy (e.g. cervical carcinoma). prior to entry into basal cells, virions attach to heparan sulfate moieties of the basement membrane. this triggers conformational changes, which affect both capsid proteins, l1 and l2, and such change ... | 2009 | 19878308 |
| oral sexual behaviors and the prevalence of oral human papillomavirus infection: oropharyngeal cancer, "safer sex," and human immunodeficiency virus infection. | 2009 | 19883243 | |
| comparative prognostic value of hpv16 e6 mrna compared with in situ hybridization for human oropharyngeal squamous carcinoma. | a significant proportion of oropharyngeal squamous cell carcinomas (oscc) are associated with the human papilloma virus (hpv), particularly hpv16. the optimal method for hpv determination on archival materials however, remains unclear. we compared a quantitative real-time polymerase chain reaction (qrt-pcr) assay for hpv16 mrna to a dna in situ hybridization (ish) method, and evaluated their significance for overall (os) and disease-free (dfs) survival. | 2009 | 19884544 |
| actual vs preferred sources of human papillomavirus information among black, white, and hispanic parents. | 2009 | 19884601 | |
| vaccinate or not? poep says physicians don't always suggest hpv vaccine. | even though the human papillomavirus vaccine has preventive benefits, a texas medical association survey shows texas physicians are slow to recommend it consistently to their young female patients. | 2009 | 19885756 |
| association of cystic neck metastases and human papillomavirus-positive oropharyngeal squamous cell carcinoma. | human papillomavirus is an established cause of oropharyngeal squamous cell carcinoma. similar to cervical cancer, these cancers are usually caused by high-risk human papillomavirus types 16 and 18 and are associated with high-risk sexual behaviors. human papillomavirus-associated oropharyngeal squamous cell carcinoma typically affects the palatine and lingual tonsils and frequently results in cystic neck metastases. the histopathology of this subset of head and neck squamous cell carcinoma is u ... | 2009 | 19886714 |
| [head and neck squamous cell cancer]. | head and neck squamous cell carcinoma (hnscc) is relatively common and is strongly related to smoking and alcohol consumption but infection by human papillomavirus has also emerged as a risk factor for hnscc. the treatment of these tumors is complicated and patients are best served by a multidisciplinary team. the therapy now commonly involves a multidisciplinary approach including surgery, radiation treatment and chemotherapy. lower stage disease carries a relatively good prognosis. the treatme ... | 2009 | 19858546 |
| human papillomavirus knowledge and awareness among undergraduates in healthcare training in new zealand. | to describe knowledge of hpv and its transmission, knowledge of the hpv vaccine, and awareness of free hpv vaccine for 12-18 year old new zealand females; and to assess whether there are significant age and gender differences in hpv-related knowledge. | 2009 | 19859090 |
| diindolylmethane inhibits cervical dysplasia, alters estrogen metabolism, and enhances immune response in the k14-hpv16 transgenic mouse model. | this study was designed to establish whether 3,3'-diindolylmethane (dim) can inhibit cervical lesions, alter estrogen metabolism in favor of c-2 hydroxylation, and enhance immune function in the k14-hpv16 transgenic mouse model. mice were bred, genotyped, implanted with e(2) pellets (0.25 mg/90-day release) under anesthesia, and divided into groups. wild-type and transgenic mice were given either ain76a diet alone or with 2,000 ppm dim for 12 weeks. blood and reproductive tracts were obtained. b ... | 2009 | 19861518 |
| the prevalence of human papillomavirus type 58 in chinese patients with cervical carcinoma and its influence on survival. | to assess the prevalence of human papillomavirus (hpv) type-specific infections and its influence on prognosis and survival rate of cervical cancer patients treated with radiotherapy alone or in combination with chemotherapy or hyperthermotherapy or both. | 2009 | 19875274 |
| risk messages about hpv, cervical cancer, and the hpv vaccine gardasil: a content analysis of canadian and u.s. national newspaper articles. | the human papillomavirus vaccine (gardasil) is a significant advancement in women's health. we compared the reporting of fear-inducing messages about human papillomavirus, cervical cancer, and the human papillomavirus vaccine in canadian and u.s. national newspapers between january 2006 and december 2007. significant differences between countries were found in the number of articles containing fear messages about human papillomavirus, cervical cancer, and the human papillomavirus vaccine. educat ... | 2009 | 19851946 |
| evaluation of quadrivalent hpv 6/11/16/18 vaccine efficacy against cervical and anogenital disease in subjects with serological evidence of prior vaccine type hpv infection. | in the quadrivalent (types 6/11/16/18) hpv vaccine (gardasil/silgard) clinical program, 73% of women aged 16-26 were naïve to all vaccine hpv types. in these women, prophylactic administration of the vaccine was highly effective in preventing hpv 6/11/16/18-related cervical disease. of the remaining women, 15% of had evidence of past infection with one or more vaccine hpv types (seropositive and dna negative) at the time of enrollment. here we present an analysis in this group of women to determ ... | 2009 | 19855170 |
| human papillomavirus types in invasive cervical cancer specimens from turkey. | the main aim of the study is to describe the human papillomavirus (hpv) type-specific distribution in invasive cervical cancer (icc) specimens from turkey. paraffin-embedded icc specimens were identified from the histopathologic archives of the hacettepe university medical school in turkey. hpv detection was carried out through amplification of hpv dna by a spf-10 broad-spectrum primer polymerase chain reaction and subsequently followed by dna enzyme immunoassay and genotyping by lipa25 (version ... | 2009 | 19851201 |
| resolution of recurrent conjunctival papilloma after topical and intralesional interferon alpha2b with partial excision in a child. | the human papilloma virus (hpv) is a double-stranded dna virus that infects the epithelium of skin and mucosa. simple treatment of conjunctival papilloma is associated with recurrences, and while most medical therapy has met with limited success, interferon alpha 2b (ifn alpha2b) may be effective. in this report, we describe a 7-year-old child with severe, recurrent conjunctival papilloma who had complete regression of the papilloma after topical and intralesional ifn alpha2b with partial excisi ... | 2009 | 19840738 |
| cost-effectiveness of human papillomavirus vaccination and cervical cancer screening in women older than 30 years in the united states. | women older than 30 years are the main beneficiaries of improved cervical cancer screening with human papillomavirus (hpv) dna testing. the role of vaccination against hpv types 16 and 18, which is recommended routinely for preadolescent girls, is unclear in this age group. | 2009 | 19841455 |
| evaluation of an elisa for p16ink4a as a screening test for cervical cancer. | the low sensitivity of cytology and low specificity of human papillomavirus testing prompts searching for more accurate cervical cancer screening strategies. our goal was to evaluate an elisa-based test for p16(ink4a). | 2009 | 19843667 |
| methylation of the long control region of hpv16 is related to the severity of cervical neoplasia. | oncogenic human papillomavirus (hpv) is the cause of cervical cancer. hypermethylation of the cpg islands located at the long control region (lcr) of the hpv genome may regulate the expression of the major oncogenes e6 and e7, and may relate to cancer progression. the goal of the present study was to investigate the methylation patterns of cpg dinucleotides contained within the lcr of the hpv16 genome in a collection of clinical specimens comprising the full spectrum of cervical carcinogenesis. | 2009 | 19819061 |
| the nonsynonymous single-nucleotide polymorphisms in codon 31 of p21 gene and the susceptibility to cervical cancer in chinese women. | it was suggested that single-nucleotide polymorphisms in p21 codon 31 seem to be associated with a variety of human malignancies; very few studies have focused on the association between p21 codon 31 polymorphisms and cervical cancer. this study explored whether p21 codon 31 nonsynonymous single-nucleotide polymorphisms might be associated with an increased risk of cervical cancer development among chinese women. | 2009 | 19820361 |
| human papillomavirus infection: low-risk and high-risk genotypes in women in catania, sicily. | human papillomavirus (hpv) infection has been strongly and consistently associated with cervical carcinoma and its cytologic precursors, such as squamous intraepithelial lesions. a cross-sectional survey was conducted with the aim of estimating the prevalence of cervical hpv infection in women attending a service of colposcopy in catania, eastern sicily, italy. | 2009 | 19820375 |
| anal condyloma acuminatum. | anal condyloma acuminatum is a human papillomavirus (hpv) that affects the mucosa and skin of the anorectum and genitalia. anal condyloma acuminatum is the most commonly diagnosed sexually transmitted disease in the united states. to date, there are more than 100 hpv types, with hpv-6, hpv-10, and hpv-11 predominately found in the anogenital region and causing approximately 90% of genital warts. risk factors for anal condyloma acuminatum include multiple sex partners, early coital age, anal inte ... | 2009 | 19820442 |
| human papillomavirus-16 e7 interacts with glutathione s-transferase p1 and enhances its role in cell survival. | human papillomavirus (hpv)-16 is a paradigm for "high-risk" hpvs, the causative agents of virtually all cervical carcinomas. hpv e6 and e7 viral genes are usually expressed in these tumors, suggesting key roles for their gene products, the e6 and e7 oncoproteins, in inducing malignant transformation. | 2009 | 19826491 |
| clinical performance of human papillomavirus e6 and e7 mrna testing for high-grade lesions of the cervix. | infection with high-risk (hr) human papillomavirus (hpv) is the major cause of cervical cancer. however, relatively few infections progress to malignant disease. progression to malignancy requires the overexpression of the e6 and e7 genes in the integrated hpv genome. it follows that the e6 and e7 transcripts could be useful markers of disease progression. the study presented here tests this possibility, using data from colposcopy and from cytological and histological tests to compare rna assays ... | 2009 | 19828739 |
| prevalence of human papillomavirus 16 and 18 neutralizing antibodies in prenatal women in british columbia. | human papillomavirus (hpv) type 16 and 18 neutralizing antibody (nab) titers were measured in 1,020 prenatal women in british columbia aged 15 to 39. hpv 16 and 18 nabs were detected in 183/1,020 (17.9%) and 97/1,020 (9.5%), respectively, and 39 (3.8%) had nabs to both types. titers were similar across age strata. | 2009 | 19828766 |
| immortalization of ameloblastoma cells via reactivation of telomerase function: phenotypic and molecular characteristics. | ameloblastoma (am) is recognized as a benign tumour but locally invasive with a high risk of recurrence. in vitro model systems for studying am are limited due to the fact that am cells grow poorly and begin to senesce early. japanese researchers have reported the construction of an am cell line, am-1, by exposing cells to human papillomavirus 16 (hpv16) but retaining the potential of transformation. in this study, we used a retroviral infection method to over-express the human telomerase revers ... | 2009 | 19833545 |
| bacterial vaginosis: a cause of infertility? | bacterial vaginosis (bv) is a common disorder of the genital tract in women characterized by an alteration of the normal acidic lactobacilli-predominant vaginal ecosystem to a vaginal environment dominated by gardnerella vaginalis, mycoplasma species and anaerobes, with an increase in ph. the present study evaluated whether bv is associated with reproductive complications in women. bv was screened with a gram stain of vaginal smear and interpretation was done using the nugent score. wet mount an ... | 2009 | 19833694 |
| [expression, purification and immunogenicity analysis of hpv type 18 virus-like particles from escherichia coli]. | here, we presented a method to bacterially express the major structural protein l1 of human papillomavirus type 18 (hpv18) as soluble form. we found that the purified l1 could self-assemble to virus-like particles (vlps). further, we investigated the immunogenicity and the induced level of neutralizing antibody using these vlps. first, the genome of hpv18 was cloned from a patient in xiamen. it was used as template for pcr amplification of hpv18 l1 gene. the resultant dna fragment was inserted i ... | 2009 | 19835152 |
| cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by e2. | this study systematically examined the viral long control region (lcr) activities and their responses to e2 for human papillomavirus (hpv) types 11, 16, and 18 as well as bovine papillomavirus 1 (bpv1) in a number of different cell types, including human cervical cancer cell lines, human oral keratinocytes, bj fibroblasts, as well as cv1 cells. the study revealed cell- and virus-type specific differences among the individual lcrs and their regulation by e2. in addition, the integration of the lc ... | 2009 | 19836046 |
| characterization of papillomavirus e1 helicase mutants defective for interaction with the sumo-conjugating enzyme ubc9. | the e1 helicase from bpv and hpv16 interacts with ubc9 to facilitate viral genome replication. we report that hpv11 e1 also interacts with ubc9 in vitro and in the yeast two-hybrid system. residues in e1 involved in oligomerization (353-435) were sufficient for binding to ubc9 in vitro, but the origin-binding and atpase domains were additionally required in yeast. nuclear accumulation of bpv e1 was shown previously to depend on its interaction with ubc9 and sumoylation on lysine 514. in contrast ... | 2009 | 19836047 |
| direct visual detection of dna based on the light scattering of silica nanoparticles on a human papillomavirus dna chip. | a detection system for a human papillomavirus (hpv) dna chip based on the light scattering of aggregated silica nanoparticle probes is presented. in the assay, a target hpv dna is sandwiched between the capture dna immobilized on the chip and the probe dna immobilized on the plain silica nanoparticle. the spot where the sandwich reaction occurs appears bright white and is readily distinguishable to the naked eye. scanning electron microscopy images clearly show the aggregation of the silica nano ... | 2009 | 19836580 |
| appropriate human papillomavirus vaccination strategies. | 2009 | 19837249 | |
| knowledge and early adoption of the hpv vaccine among girls and young women: results of a national survey. | in 2006, universal human papillomavirus (hpv) vaccination of females ages 9 to 26 years became a formal recommendation, yet little is known about knowledge and adoption of this vaccine. | 2009 | 19837351 |
| parental response to human papillomavirus vaccine availability: uptake and intentions. | this study examined parental responses to the quadrivalent human papillomavirus (hpv) vaccine approximately 2 years post-licensure. correlates of vaccine uptake included daughter age, physician recommendation, and parental knowledge, beliefs, and attitudes. correlates of vaccination intentions were consistent with previous research. findings can inform future efforts aimed at promoting hpv vaccination. | 2009 | 19837361 |
| an experimental investigation of the emotional and motivational impact of hpv information in adolescents. | we examined psychologic responses to information about human papillomavirus (hpv) in young women within the age range of the uk's hpv vaccination "catch-up" program (13-16 years). respondents absorbed hpv information without becoming worried, were receptive to cervical screening and vaccination, and these attitudes were enhanced by presentation of relevant information. | 2009 | 19837362 |
| how do we manage vaccinations in patients with inflammatory bowel disease? | the mortality in inflammatory bowel disease (ibd) has been reported similar or slightly increased as compared to that of the general population. however, deaths related to infectious and parasitic diseases have been repeatedly reported in clinical trials, open series and registries. the ibd patients are exposed to the same infections affecting the community, added to opportunistic infectious related to the immunosuppression. some of these infectious diseases may be prevented by the appropriate u ... | 2009 | 19786767 |
| correlation of cxcl12 expression and foxp3+ cell infiltration with human papillomavirus infection and clinicopathological progression of cervical cancer. | human cervical cancer is an immunogenic tumor with a defined pattern of histopathological and clinical progression. tumor-infiltrating t cells contribute to immune control of this tumor; however, cervical cancer dysregulates this immune response both through its association with human papillomavirus (hpv) infection and by producing cytokines and chemokines. animal tumor models have revealed associations between overproduction of the chemokine stromal cell-derived factor-1 (sdf-1 or cxcl12) and d ... | 2009 | 19808652 |
| [expression and functional analysis of crt-e2-egfp fusion protein in b16 cells]. | to detect the expression of the calreticulin and hpv e2 fusion protein in b16, and study the effects on proliferation and apoptosis of b16 cell lines in vivo. | 2009 | 19811736 |
| trials comparing cytology with human papillomavirus screening. | 2009 | 19796748 | |
| pre-malignant nasopharyngeal epithelial cell models. | experimental models that allow investigation of nasopharyngeal carcinoma(npc) progression could provide valuable insights of the molecular mechanism of nasopharyngeal carcinogenesis as well as potential clinical intervention. because epstein-barr virus only infects humans and a few species of monkeys, representative npc animal models have not been available so far. attempts to provide cell models for early nasopharyngeal carcinogenesis have involved in the studies of in vitro transformation of n ... | 2009 | 19799806 |
| anti-tumor cd8+ t cell immunity elicited by hiv-1-based virus-like particles incorporating hpv-16 e7 protein. | here we report a novel strategy for the induction of cd8(+) t cell adaptive immune response against viral and tumor antigens. this approach relies on high levels of incorporation in hiv-1 vlps of a mutant of hiv-1 nef (nef(mut)) which can act as anchoring element for foreign proteins. by in vitro assay, we found that vlp-associated nef(mut) is efficiently cross-presented by antigen presenting cells. inoculation in mice of vlps incorporating the hpv-16 e7 protein fused to nef(mut) led to an anti- ... | 2009 | 19800648 |
| virus-like particle vaccines and adjuvants: the hpv paradigm. | complex antigen structures currently represent the most-studied approach for prophylactic as well as therapeutic vaccines. different types of complex vaccines, including virus-like particles and virosomes, have been developed depending on the nature of the viral pathogen they are trying to replicate (enveloped vs naked) or the modality to express antigenic epitopes (i.e., the binding of envelope protein on liposomic structures). the complex structure of these vaccines provides them with some adj ... | 2009 | 19803760 |
| [the role of colposcopy and typization of human papillomavirus in further diagnostic proceedings in patients with asc-us cytological finding of the uterine cervix]. | bethesda system of classification of cytological findings was introduced in 2001 two subcategories in the category of atypical squamous cells (asc) findings: asc of undetermined significance (asc-us) and asc which cannot exlude high-grade intraepithelial lesions (asc-h). the aim of our study was to assess a possible association of these two subcategories with pathologic biopsy finding and to find out the best further diagnostic proceedings. | 2009 | 19780421 |
| [the occurrence of human papillomavirus--hpv in the biopsies from colon polyps and cancer]. | human papillomaviruses (hpv) infection can be associated with benign (warts) and malignant (precancer and cancer) genital, perianal and oral lesions. the role of hpv in the pathogenesis of colonorectal cancer and adenomas is still undetermined. we investigated the occurrence of nononcogenic hpv 6/11 and oncogenic 16/18 dna in colon cancer, polyps and normal tissue using pcr. hpv 16/18 were detected more frequently in colon cancers (67%) and adenomas (56%) than in normal colon mucosa (28%). in ca ... | 2009 | 19780498 |
| the human papillomavirus 16 e2 protein is stabilised in s phase. | the human papillomavirus 16 e2 protein regulates transcription from, and replication of, the viral genome and is also required for segregation of the viral genome via interaction with mitotic bodies. to regulate dna replication e2 interacts with sequences around the origin of replication and recruits the viral helicase e1 via a protein-protein interaction, which then initiates viral genome replication. the replication role of e2 must originally function in a host cell s phase. in this report, we ... | 2009 | 19781729 |