Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| aortic endostent followed by extended pneumonectomy for t4 lung cancer. | pulmonary and aortic en bloc resection may be performed with cardiopulmonary bypass support, but is associated with high surgical morbidity and mortality. a 59-year-old man with left lower lobe cancer invading the aorta was considered to be unsuitable for such an extended operation because of previous myocardial infarction, coronary bypass grafts, and subsequent multiple coronary artery stenting. pneumonectomy with en bloc resection of aortic adventitia and media was accomplished after thoracic ... | 2011 | 21256322 |
| comparison of progressive cephalometric changes and postsurgical stability of skeletal class iii correction with and without presurgical orthodontic treatment. | this study compares 1) progressive dental and skeletal changes, 2) postsurgical stability, and 3) treatment efficacy of patients with skeletal class iii correction with and without presurgical orthodontic treatment. | 2011 | 21256648 |
| duplication of calsequestrin genes in teleosts: molecular characterization in the senegalese sole (solea senegalensis). | calsequestrin is a moderate-affinity, high-capacity ca(2+) binding protein in the sarcoplasmic reticulum of skeletal and cardiac muscle that seems to act as an intralumenal ca(2+) buffer. two different isoforms have been described in mammals, the skeletal and cardiac isoforms, encoded by casq1 and casq2 genes, respectively. in this study, we present molecular phylogenetic evidence of a gene duplication event of both calsequestrin genes in teleosts, referred to as casq1a/casq1b and casq2a/casq2b. ... | 2011 | 21256971 |
| mutational analysis of residues in the helical region of the class iia bacteriocin pediocin pa-1. | a 15-mer fragment that is derived from the helical region in the c-terminal half of pediocin pa-1 inhibited the activity of pediocin pa-1. of 13 other pediocin-like (hybrid) bacteriocins, only the hybrid bacteriocin sak/ped was markedly inhibited by the 15-mer fragment. sak/ped was the only one of these bacteriocins that had a sequence (in the c-terminal helix-containing half) identical to that of the 15-mer fragment, indicating that the fragment inhibits pediocin-like bacteriocins in a sequence ... | 2011 | 21257813 |
| a research framework for reducing preventable patient harm. | programs to reduce central line-associated bloodstream infections (clabsis) have improved the safety of hospitalized patients. efforts are underway to disseminate these successes broadly to reduce other types of hospital-acquired infectious and noninfectious preventable harms. unfortunately, the ability to broadly measure and prevent other types of preventable harms, especially infectious harms, needs enhancement. moreover, an overarching research framework for creating and integrating evidence ... | 2011 | 21258104 |
| hedgehog-mediated regulation of thyroid hormone action through iodothyronine deiodinases. | introduction: the three iodothyronine deiodinases catalyze the metabolic pathway that removes one iodine residue from the t4 molecule, thus producing either the active t3 or the inactive metabolite rt3. hence, deiodination is a potent mechanism by which to modulate thyroid hormone (th) action at cellular level, thereby allowing cells to customize their own t3 availability, both spatially and temporally, irrespective of th serum concentrations. sonic hedgehog (hh) regulates patterning and growth ... | 2011 | 21261564 |
| endorectal ultrasound in rectal carcinoma--do the literature results really correspond to the realities of routine clinical care? | this multicenter, prospective, country-wide quality-assurance study at more than 300 hospitals in germany was designed to characterize and analyze the diagnostic accuracy of rectal endoscopic ultrasound (eus) in the routine clinical staging of rectal carcinoma (depth of tumor infiltration). | 2011 | 21234855 |
| thyroid status of space shuttle crewmembers: effects of iodine removal. | iodine is often used for water purification and has been used throughout the u.s. space program. because of concern about potential effects on crewmembers' thyroid function, in 1997 a system was implemented on board the space shuttles to remove iodine from water before it was consumed. we report here thyroid hormone data from crews flying before and after this system was implemented. | 2011 | 21235106 |
| plasma acetate, gluconate and interleukin-6 profiles during and after cardiopulmonary bypass: a comparison of plasma-lyte 148 with a bicarbonate-balanced solution. | as even small concentrations of acetate in the plasma result in pro-inflammatory and cardiotoxic effects, it has been removed from renal replacement fluids. however, plasma-lyte 148 (plasma-lyte), an electrolyte replacement solution containing acetate plus gluconate is a common circuit prime for cardio-pulmonary bypass (cpb). no published data exist on the peak plasma acetate and gluconate concentrations resulting from the use of plasma-lyte 148 during cpb. | 2011 | 21235742 |
| immediate effects of the audible pop from a thoracic spine thrust manipulation on the autonomic nervous system and pain: a secondary analysis of a randomized clinical trial. | this study investigated the immediate effects of audible joint sounds following a supine t3-t4 spinal thrust manipulation on the autonomic nervous system activity using a fully automated pupillometry system in patients with chronic neck pain. an additional aim was to determine if audible sounds as perceived by the therapist were associated with the reduction of pain following manipulation. | 2011 | 21237406 |
| endonuclease vii is a key component of the mismatch repair mechanism in bacteriophage t4. | in previous papers we described an extra recombination mechanism in t4 phage, which contributed to general recombination only when particular mutations were used as geneticmarkers (high recombination or hr markers), whereas it was practically inactive towards other riib mutations (low recombination or lr markers). this marker-dependent recombination pathway was identified as a repair of mismatches in recombination heteroduplexes. we suggested that the first step in this pathway, recognition and ... | 2011 | 21237725 |
| analysis of preexistent vertebral rotation in the normal infantile, juvenile, and adolescent spine. | vertebral rotation was systematically analyzed in the normal, nonscoliotic thoracic spine of children aged 0 to 16 years. subgroups were created to match the infantile, juvenile, and adolescent age groups according to the criteria of the scoliosis research society. | 2011 | 21240053 |
| objective evaluation of patients with palmar hyperhidrosis submitted to two levels of sympathectomy: t3 and t4. | this study compares the results obtained of video-assisted sympathectomy performed on two distinct ganglion levels (third vs. fourth thoracic ganglion) in the treatment of palmar hyperhidrosis (ph), through a blind randomized clinical trial. all participants were randomized into two groups of 20 patients (g3 and g4) and underwent the operation, and were followed for 12 months. we used an objective method for measuring sweat, checking the transepidermal water loss (tewl), and evaluated the qualit ... | 2011 | 21233258 |
| is neoadjuvant chemotherapy prior to radio-chemotherapy beneficial in t4 anal carcinoma? | this study retrospectively describes the outcome of a series of 38 patients (pts) with t4 anal carcinoma exclusively treated by radio and chemotherapy. | 2011 | 21240983 |
| induction chemotherapy for advanced squamous cell carcinoma of the paranasal sinuses. | to review the oncologic outcomes in patients with advanced (stage iii-iv) squamous cell carcinoma of the paranasal sinuses treated with induction chemotherapy prior to definitive local therapy. | 2011 | 21242552 |
| t2-t4 sympathectomy versus t3-t4 sympathicotomy for palmar and axillary hyperhidrosis. | to evaluate and compare the immediate and long-term outcomes of videothoracoscopic t2-t4 sympathectomy and t3-t4 sympathicotomy for the treatment of palmar and axillary hyperhidrosis. | 2011 | 21243401 |
| the prevalence of vertebral fractures and health-related quality of life in postmenopausal women. | vertebral fractures are the hallmark of osteoporosis, responsible for increased back pain, impairment of mobility and functional limitations. these factors have an impact on patients' health-related quality of life (qol). the aim of this study was to evaluate the prevalence of vertebral fractures in moroccan postmenopausal women and to assess their qol, using an arabic validated version of qualeffo. the study recruited 347 postmenopausal women in obvious good health. we excluded women who had us ... | 2011 | 21243498 |
| relevance of autoimmune thyroiditis in children and adolescents with vitiligo. | vitiligo is the most common pigmentation-related disorder worldwide. an autoimmune etiology is widely considered, and genetic factors may play an important role in its pathogenesis. the purpose of this study was to assess the incidence of thyroid dysfunctions and autoimmune thyroiditis in children with vitiligo and to identify related factors. | 2011 | 21244381 |
| foxp3 and survival in urinary bladder cancer. | objective: • to investigate the possible impact of foxp3 expression in t-cells, as well as in tumour cells, on long-term survival in patients with urinary bladder cancer (ubc) invading muscle. patients and methods: • in a retrospective study, tumour specimens from 37 patients cystectomized for t1-t4 ubc during 1999-2002 at the karolinska university hospital were examined by immunohistochemistry for tumour expression and/or infiltration of immune cells expressing foxp3 as well as cd3. • the resul ... | 2011 | 21244603 |
| metformin decreases thyrotropin in overweight women with polycystic ovarian syndrome and hypothyroidism. | to assess the effect of metformin administration on thyroid function in overweight women with polycystic ovarian syndrome (pcos). | 2011 | 21262871 |
| thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis. | to observe the influence of thyroid hormone therapy on hypothalamo-pituitary-adrenal (hpa) axis, a group of 14 athyreotic women due to thyroid cancer treatment were studied before and after thyroid suppression therapy with thyroxine (t4). changes in plasma adrenocorticotropin (acth) and cortisol levels in response to human corticotropin-releasing hormone (hcrh; 100µg, i.v.) were estimated under hypothyroid conditions and after t4 suppression therapy with 2.5µg/kg/day for two months (n=14). a gro ... | 2011 | 21263198 |
| quantitative analysis of promoter methylation of the ednrb gene in gastric cancer. | hypermethylation has been shown in the promoter region of the endothelin receptor b (ednrb) gene in several human tumors. however, its role in gastric cancer formation is still unclear. in this study, the methylation status of the ednrb gene in paired gastric cancer tissues and adjacent normal tissues from 96 patients was detected quantitatively using pyrosequencing. the results showed the methylation of promoter of ednrb gene in gastric cancer (50.42 ± 9.03%) was significantly higher than in ad ... | 2011 | 21264540 |
| laryngeal carcinoma metastasis to the orbit: case report. | we present the first report in the all english literature of a case of laryngeal squamous cell carcinoma metastasis to the orbit. | 2011 | 21269558 |
| targeted thyroid testing in acute illness - achieving success through audit. | thyroid tests are done in acutely ill patients who often have confusing transient thyroid abnormalities, despite a lack of clarity about intervention and cost benefit. a retrospective analysis of patients admitted to the medical assessment unit [mau] was undertaken in 2004 to assess the frequency and utility, pattern of abnormalities and cost of thyroid testing. guidelines were issued and the audit was repeated in 2008. 53.8% of 1593 were offered thyroid tests in 2004 with a significant reductio ... | 2011 | 21270508 |
| thoracic pedicle morphometry in different body-height population: a three dimensional study using reformatted computed tomography. | study design. a three-dimensional study of the thoracic pedicle (t1-t12) morphometry in chinese patients, with different body-height, using reformatted computed tomography.objective. to quantify the dimensions of the thoracic pedicles and to analyze the relationship between body-height and thoracic pedicle parameters.summary of background data. the thoracic pedicle morphometry has been studied extensively in different populations using various techniques. previous studies have shown a significan ... | 2011 | 21270680 |
| integrated analysis of the conformation of a protein-linked spin label by crystallography, epr and nmr spectroscopy. | long-range structural information derived from paramagnetic relaxation enhancement observed in the presence of a paramagnetic nitroxide radical is highly useful for structural characterization of globular, modular and intrinsically disordered proteins, as well as protein-protein and protein-dna complexes. here we characterized the conformation of a spin-label attached to the homodimeric protein cylr2 using a combination of x-ray crystallography, electron paramagnetic resonance (epr) and nmr spec ... | 2011 | 21271275 |
| thyroid hormones (t3 and t4): dual effect on human cancer cell proliferation. | several findings suggest that the patient's hormonal context plays a crucial role in determining cancer outcome. the exact nature of thyroid hormone action on tumour growth has not been established yet, in fact contrasting data show thyroid hormones have a promotory or an inhibitory action on cancer cell proliferation depending on the case. we hypothesized that not only tissue specificity, but also specific mutations occurring during tumoral development in different thyroid hormone cellular targ ... | 2011 | 21273585 |
| coagulation disorders in patients with locally advanced head and neck cancer - should they really be disregarded? | the aim of the study was to analyse coagulation disorders in patients with locally advanced cancer of the head and neck (chn)and with no other clinical cause for coagulation disorders treated with radiation therapy alone or concurrent chemoradiotherapy. we also assessed the duration of disorders in the course of therapy. the analysed group consisted of 33 patients with locally advanced chn documented as stage t3 or t4 acc. to the tnm classification. coagulology tests (activated partial thrombopl ... | 2011 | 21275462 |
| long-term stability after multilevel cervical laminectomy for spinal cord tumor resection in von hippel-lindau disease. | despite the frequent multiplicity and development of new spinal cord hemangioblastomas that require multiple resections in patients with von hippel-lindau (vhl) disease, the long-term effects of spinal surgery on spinal column stability in this neoplasia disorder are not known. to determine the effect of multilevel cervical laminectomy for spinal cord tumor resection in vhl, the authors analyzed long-term clinical and radiographic outcomes. | 2011 | 21275550 |
| cervical lymph node metastases in squamous cell carcinoma of tongue and floor of mouth. | oral squamous cell carcinoma has high chances of cervical lymph node metastasis. this case series describes the distribution of cervical lymph nodes in 50 cases of squamous cell carcinoma of tongue and floor of mouth. the mean age was 47.28±10.5 years. thirty positive metastatic lymph nodes were found; 90% occurring at level i-ii mostly in t4 size but also in t1 and t2 cases. the distribution of involved lymph nodes in oral cancer affects the neck dissection extent and is, therefore, an importan ... | 2011 | 21276390 |
| effect of whole pelvic radiotherapy for patients with locally advanced prostate cancer treated with radiotherapy and long-term androgen deprivation therapy. | purpose: to evaluate the effect of whole pelvic radiotherapy (wprt) in prostate cancer patients treated with rt and long-term (>1 year) androgen deprivation therapy (adt). methods and materials: prostate cancer patients with high-risk features (stage t3-t4 and/or gleason score =7 and/or prostate-specific antigen level =20 ng/ml) who had undergone rt and long-term adt were included in the present analysis. patients with bowel inflammatory disease, colon diverticula, and colon diverticulitis were ... | 2011 | 21277100 |
| impact of neoadjuvant chemoradiotherapy followed by surgical resection on node-negative t3 and t4 non-small cell lung cancer. | this study examined the impact of neoadjuvant chemotherapy and concurrent high-dose radiation therapy on survival in patients with node-negative t3 and t4 non-small cell lung cancer. | 2011 | 21281948 |
| [knot in a thoracic epidural catheter]. | we report a case of impossible injection into a thoracic epidural catheter associated with a difficult withdrawal of this catheter after its introduction on the t3-t4 level. thanks to a gentle and continuous traction, the catheter was finally successfully removed without being broken, but presented a simple knot at 13mm from its end. no neurological complication was observed later on. this complication happened during the introduction of the catheter at the thoracic level where anatomic conditio ... | 2011 | 21282033 |
| tumor site and perigastric nodal status are the most important predictors of para-aortic nodal involvement in advanced gastric cancer. | this study was designed to identify pathological predictors of para-aortic nodal invasion in advanced gastric cancer. | 2011 | 21286941 |
| intensity-modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal. | the purpose of this study was to compare outcomes in patients with anal canal squamous cell carcinoma (scca) who were treated with definitive chemoradiotherapy by either intensity-modulated radiation therapy (imrt) or conventional radiotherapy (crt). | 2011 | 21287530 |
| the terminal region of the e. coli chromosome localises at the periphery of the nucleoid. | bacterial chromosomes are organised into a compact and dynamic structures termed nucleoids. cytological studies in model rod-shaped bacteria show that the different regions of the chromosome display distinct and specific sub-cellular positioning and choreographies during the course of the cell cycle. the localisation of chromosome loci along the length of the cell has been described. however, positioning of loci across the width of the cell has not been determined. | 2011 | 21288323 |
| a novel method for testing the veridicality of dental colour assessments. | the commission internationale de l'eclairage (cie) l*a*b* three-dimensional coordinates suggest strong correlations between the data of a* (red-green axis) and b* (blue-yellow axis), as both are located on the same plane in the model and should therefore show a strong dependency. in order to assess the veridicality of colour determinations, the null hypothesis of no significant changes in cie-a*/b* coherences of dental colours following a colour or lightness change induced by external dental ble ... | 2011 | 21289016 |
| loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to cd4 antibody ibalizumab. | ibalizumab (formerly tnx-355) is a first-in-class, monoclonal antibody inhibitor of cd4-mediated human immunodeficiency type 1 (hiv-1) entry. multiple clinical trials with hiv-infected patients have demonstrated the antiviral activity, safety, and tolerability of ibalizumab treatment. a 9-week phase ib study adding ibalizumab monotherapy to failing drug regimens led to transient reductions in hiv viral loads and the evolution of hiv-1 variants with reduced susceptibility to ibalizumab. this repo ... | 2011 | 21289125 |
| the volumetric analysis of cement in vertebroplasty: relationship with clinical outcome and complications. | prospective study. | 2011 | 21289575 |
| bilateral pars fractures complicating long fusion to l5 in a patient with rheumatoid arthritis. | case report. | 2011 | 21289579 |
| effects of methylphenidate on performance of a practical pistol shooting task: a quantitative electroencephalography (qeeg) study. | 2011 | 21294887 | |
| two-year results from a swedish study on conventional versus accelerated radiotherapy in head and neck squamous cell carcinoma - the artscan study. | studies on accelerated fractionation (af) in head and neck cancer have shown increased local control and survival compared with conventional fractionation (cf), while others have been non-conclusive. in 1998 a national swedish group decided to perform a randomised controlled clinical study of af. | 2011 | 21295880 |
| a rare case of anterior thoracic myelomeningocele with scoliosis--case report and review of the literature. | spinal deformities associated with spinal dysraphism are a challenging problem. myelomeningocele has been reported in the lumbar spine. however, it is rare in the thoracic spine. | 2011 | 21296287 |
| recombinant human thyroid stimulating hormone in thyroid remnant ablation with 1.1 gbq 131iodine in low-risk patients. | objective: to evaluate the efficacy of recombinant human thyroid stimulating hormone [rhtsh (versus hypothyroidism)] in thyroid ablation with an activity of 1.1 gbq (30 mci) i. methods: a total of 102 patients with thyroid cancer who fulfilled the following criteria were studied: submitted to total thyroidectomy with complete tumor resection; tumor =4 cm without extrathyroid invasion or lymph node metastases; negative anti-thyroglobulin (anti-tg) antibodies. thirty-two patients (group a) receive ... | 2011 | 21297429 |
| discovering conformational sub-states relevant to protein function. | internal motions enable proteins to explore a range of conformations, even in the vicinity of native state. the role of conformational fluctuations in the designated function of a protein is widely debated. emerging evidence suggests that sub-groups within the range of conformations (or sub-states) contain properties that may be functionally relevant. however, low populations in these sub-states and the transient nature of conformational transitions between these sub-states present significant c ... | 2011 | 21297978 |
| clinicopathologic features and prognosis analysis of mucinous gastric carcinoma. | mucious gastric carcinoma (mgc) is a subtype of gastric carcinoma and its clinicopathologic features and prognosis still remain unclear. to investigate the clinical significance and surgical outcomes of mucinous gastric carcinoma, 2,769 patients with gastric carcinoma were analyzed in a case control study. we reviewed the records of 196 patients with mucinous gastric carcinoma and 2,573 with nonmucinous gastric carcinoma (ngc). clinicopathologic features and survival rate of patients were analyz ... | 2011 | 21298368 |
| enhancer of zeste homolog 2 overexpression in nasopharyngeal carcinoma: an independent poor prognosticator that enhances cell growth. | purpose: as a key component of polycomb-repressive complex 2, enhancer of zeste homolog 2 (ezh2) represses target genes through histone methylation and is frequently overexpressed and associated with poor prognosis in common carcinomas. for the first time, we reported ezh2 expression and its biological and clinical significance in nasopharyngeal carcinoma (npc). methods and materials: in npc cell lines and specimens, endogenous expression of ezh2 mrna and protein was determined by semiquantitati ... | 2011 | 21300475 |
| a novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic dna. | recently, 5-hydroxymethylcytosine (5hmc) was identified in mammalian genomic dna. the biological role of this modification remains unclear; however, identifying the genomic location of this modified base will assist in elucidating its function. we describe a method for the rapid and inexpensive identification of genomic regions containing 5hmc. this method involves the selective glucosylation of 5hmc residues by the ß-glucosyltransferase from t4 bacteriophage creating ß-glucosyl-5-hydroxymethylc ... | 2011 | 21300643 |
| ossification of the midpalatal suture after surgically assisted rapid maxillary expansion. | the purpose of this study was to evaluate ossification of the midpalatal suture in adult patients immediately after surgically assisted rapid maxillary expansion (sarme) until 120 days post-surgery. the sample comprised 126 standardized occlusal radiographs of 21 adults (14 females and 7 males; mean age: 25.33 years) taken pre-expansion (t1), immediately after expansion (t2), and post-expansion (30, 60, 90, and 120 days of retention, respectively: t3, t4, t5, and t6) who had undergone sarme. the ... | 2011 | 21300726 |
| lack of action of exogenously administered t3 on the fetal rat brain despite expression of the monocarboxylate transporter 8. | mutations of the monocarboxylate transporter 8 gene (mct8, slc16a2) cause the allan-herndon-dudley syndrome, an x-linked syndrome of severe intellectual deficit and neurological impairment. mct8 transports thyroid hormones (t4 and t3), and the allan-herndon-dudley syndrome is likely caused by lack of t3 transport to neurons during critical periods of fetal brain development. to evaluate the role of mct8 in thyroid hormone action in the fetal brain we administered t4 or t3 to thyroidectomized pre ... | 2011 | 21303950 |
| skeletal identification by radiographic comparison: blind tests of a morphoscopic method using antemortem chest radiographs. | this study investigated the value of antemortem (am) and postmortem (pm) radiographs of the claviculae and c3-t4 vertebrae to identify skeletons of missing u.s. soldiers from past military operations. in total, 12 field-recovered skeletons and am chest radiographs of 1460 individuals were used. for each skeleton, examiners analyzed an array of am chest radiographs (up to 1000 individuals) and attempted to identify the correct pm/am radiographic match. when examiners were able to compare all imag ... | 2011 | 21306373 |
| immunomarker studies of fine-needle cytopuncture cell blocks for tumor response prediction after preoperative chemotherapy and prognosis in operable nonmetastatic primary breast carcinoma. | neo-adjuvant chemotherapy of breast cancer provides an opportunity to evaluate predictive factors at initial tumor biopsy. we evaluated these factors on cell blocks obtained by diagnostic fine-needle cytopuncture (fnc), with respect to tumor regression and outcome. a prospective study (1996-2003, median follow-up 82 months) involved 163 patients with breast carcinoma (t2 = 3 cm, t3, t4 noninflammatory) diagnosed by means of fnc. malignancy, cytologic grade, and the presence of lymphocytes were d ... | 2011 | 21306468 |
| right pneumonectomy for t4 non-small cell lung cancer invading intrapericardial pulmonary vein in a patient with a right aortic arch. | a 59 year-old man with a right-sided aortic arch who had a t4 right lung cancer invading the proximal superior pulmonary vein underwent an intrapericardial-pneumonectomy with partial left atrium resection and a radical lymphadenectomy. the presence of a right-sided aortic arch required particular attention during dissection of the lymph nodes. this is the first case of a right-pneumonectomy for t4-lung cancer in a patient with a right-sided aortic arch. | 2011 | 21306950 |
| pott disease in a 13-month-old: case report. | tuberculosis (tb) is a common disease worldwide that is caused by mycobacterium tuberculosis. tb of the spine is the most common site of bony infection and is often referred to as pott disease. to the best of our knowledge, our case represents the youngest patient with naturally acquired pott disease in the united states. | 2011 | 21307787 |
| high sensitivity 5-hydroxymethylcytosine detection in balb/c brain tissue. | dna hydroxymethylation is a long known modification of dna, but has recently become a focus in epigenetic research. mammalian dna is enzymatically modified at the 5(th) carbon position of cytosine (c) residues to 5-mc, predominately in the context of cpg dinucleotides. 5-mc is amenable to enzymatic oxidation to 5-hmc by the tet family of enzymes, which are believed to be involved in development and disease. currently, the biological role of 5-hmc is not fully understood, but is generating a lot ... | 2011 | 21307836 |
| external validation of the proposed t and n categories of squamous cell carcinoma of the penis. | objectives: the aim of this study was to validate recently proposed modifications to the current tnm classification of penile squamous cell carcinoma (pscc) by using data from four german urological centers. methods: we identified 89 patients treated for histologically confirmed pscc between 1996 and 2008 and reclassified them according to the proposed tnm staging revisions. the proposed changes restricted t2 to tumoral invasion of the corpus spongiosum, whereas invasion of the corpus cavernos ... | 2011 | 21309862 |
| comparison of the prognostic accuracy of the sixth and seventh editions of the tnm classification for intrahepatic cholangiocarcinoma. | the seventh tnm edition introduced a new, specific staging structure for intrahepatic cholangiocarcinoma (ihc). | 2011 | 21309938 |
| prediction of protein-protein interactions between human host and a pathogen and its application to three pathogenic bacteria. | molecular understanding of disease processes can be accelerated if all interactions between the host and pathogen are known. the unavailability of experimental methods for large-scale detection of interactions across host and pathogen organisms hinders this process. here we apply a simple method to predict protein-protein interactions across a host and pathogen organisms. we use homology detection approaches against the protein-protein interaction databases, dip and ipfam in order to predict int ... | 2011 | 21310175 |
| lipid profile, thyroid function, and serum magnesium level in type i diabetic children. | this study aim was to investigate the changes of lipid profile, thyroid function and magnesium (mg) level in type i diabetic children. | 2011 | 21311427 |
| analysis of mel-18 expression in prostate cancer tissues and correlation with clinicopathologic features. | mel-18 is a member of the polycomb group (pcg) of proteins, which are chromatin regulatory factors that play an important role in development and oncogenesis. this study was designed to investigate the clinical and prognostic significance of mel-18 in the patients with prostate cancer. | 2011 | 19395284 |
| despite the lack of association between different genotypes and the presence of prostate cancer, endothelial nitric oxide synthase a/b (enos4a/b) polymorphism may be associated with advanced clinical stage and bone metastasis. | to investigate the relationship between the distribution of endothelial no synthase (enos4a/b) gene polymorphism and clinical features of prostate cancer (pca). | 2011 | 19576798 |
| cytotoxic effects exerted by polyarylsulfone dialyser membranes depend on different sterilization processes. | polyarylsulfone group is one of the most important polymeric materials used in the biomedical field, due to its excellent properties, such as good thermal, chemical, and mechanical stability. there are three important polyarylsulfone polymers, all of which have excellent electrical properties: polysulfone (psu), polyarylsulfone (pas) and polyarylethersulfone (paes). all these polymers have excellent creep, radiation and high temperature resistance. in this study, we aimed to determine the effect ... | 2011 | 19795219 |
| relationships of putative endocrine disruptors to human sexual maturation and thyroid activity in youth. | endocrine disruption has become a significant human health concern, but is difficult to study outside of the laboratory for several reasons including the multiplicity of exposures, the difficulty in assessing each exposure, and the variety of possible outcomes among human populations. this review summarizes our studies of the relationships of measured persistent organic pollutants (pcbs, p,p'-dde, hcb and mirex), and heavy metals (lead and mercury), to outcomes directly related to thyroid functi ... | 2010 | 19800354 |
| the impact on survival of positive intraoperative pleural lavage cytology in patients with non-small-cell lung cancer. | the aim of this study was to analyze intraoperative pleural lavage cytology results in patients with non-small-cell lung cancer and quantify the impact on survival and recurrence. | 2010 | 19765741 |
| chromogranin a (cga) serum level as a marker of progression in hepatocellular carcinoma (hcc) of elderly patients. | the observation of neuroendocrine (ne) activity during clinical course of hepatocellular carcinoma (hcc), suggested the use of ne serum markers to detect it. thus we have evaluated the usefulness of serum measurements of cga in monitoring disease activity of hcc. we investigated the role of serum concentrations of cga, alpha-fetoprotein (afp) and des-gamma-carboxyl-prothrombin (dcp) in 55 patients with hcc, 27 patients with cirrhosis, 22 patients with chronic hepatitis and a control group of 20 ... | 2010 | 19766330 |
| enhancement of dna repair using topical t4 endonuclease v does not inhibit melanoma formation in cdk4(r24c/r24c)/tyr-nras(q61k) mice following neonatal uvr. | to further investigate the use of dna repair-enhancing agents for skin cancer prevention, we treated cdk4(r24c/r24c)/nras(q61k) mice topically with the t4 endonuclease v dna repair enzyme (known as dimericine) immediately prior to neonatal ultraviolet radiation (uvr) exposure, which has a powerful effect in exacerbating melanoma development in the mouse model. dimericine has been shown to reduce the incidence of basal-cell and squamous cell carcinoma. unexpectedly, we saw no difference in penetr ... | 2010 | 19788533 |
| how should we manage patients with mildly increased serum thyrotrophin concentrations? | a mildly increased serum thyrotrophin (tsh) is usually because of mild thyroid failure, and the most common aetiology in iodine-replete communities is chronic autoimmune thyroiditis. it is more common in women, and the prevalence increases with age in both men and women and is associated with the presence of antithyroid antibodies. the majority will have serum tsh levels between 5-10 miu/l, normal free thyroxine (t4) levels and relatively few symptoms. in 2004, us evidence-based consensus guidel ... | 2010 | 19788591 |
| initial management of prostate cancer: first year experience with the norwegian national prostate cancer registry. | study type - therapy (individual cohort) level of evidence 2b | 2010 | 19735258 |
| tertiary butyl alcohol in drinking water induces phase i and ii liver enzymes with consequent effects on thyroid hormone homeostasis in the b6c3f1 female mouse. | tertiary butyl alcohol (tba) was administered to groups of 15 female b6c3f1 mice in drinking water at concentrations of 0, 2.0 or 20 mg tba ml(-1), for 14 days, for assessment of gross and histological changes in the liver and thyroid, thyroid hormones (t3, t4, and tsh), total hepatic cytochrome p450 (cyp) content, specific cyp activities and quantitative pcr analysis of specific cyp enzymes (cyp1a1, cyp2b9, cyp2b10, cyp3a11), sulfuryltransferases (st1a1, st2a2, and stn) and glucuronyltransferas ... | 2010 | 19760798 |
| assisting the diagnosis of graves' hyperthyroidism with bayesian-type and som-type neural networks by making use of a set of three routine tests and their correlation with free t4. | in our previous paper, we proposed a novel screening method that assists the diagnosis of graves' hyperthyroidism via two types of neural networks by making use of routine test data. this method can be applied by non-specialists during physical check-ups at a low cost and is expected to lead to rapid referrals for examination and treatment by thyroid specialists, that is, to improve patients' qol. in this report, the amount of female sample data was increased and routine test data (14 parameters ... | 2010 | 19762198 |
| a phase i study of capecitabine, irinotecan, celecoxib, and radiation as neoadjuvant therapy of patients with locally advanced rectal cancer. | we conducted a prospective phase i trial to determine the maximum tolerated dose of capecitabine and irinotecan when used in combination with celecoxib and radiation as preoperative therapy for patients with locally advanced rectal cancer. | 2010 | 19806036 |
| supplementation of cottonseed, linseed, and noug seed cakes on feed intake, digestibility, body weight, and carcass parameters of sidama goats. | a digestibility, feed intake, and carcass evaluation experiment using 20 yearling intact male sidama goats weighing 16.4 +/- 0.63 kg (mean +/- sd) was conducted in ethiopia with the objectives to determine feed intake, digestibility, body weight (bw) gain, and carcass parameters. the treatments included feeding natural pasture hay (t1, control) and supplementation with cottonseed cake (284 g-t2), linseed cake (250 g-t3), and noug seed cake (296 g-t4) on dry matter (dm) basis to supply 85 g crude ... | 2010 | 19809885 |
| annual sex steroid and other physiological profiles of pacific lampreys (entosphenus tridentatus). | we documented changes in plasma levels of estradiol 17-beta (e2), progesterone (p), 15alpha-hydroxytestosterone (15alpha-t), thyroxine (t4), triiodothyronine (t3), protein, triglycerides (tgs), and glucose in adult pacific lampreys (entosphenus tridentatus) held in the laboratory in two different years. levels of e2 in both sexes ranged from 0.5 to 2 ng/ml from september to march, peaked in late april (2-4 ng/ml), and decreased in may, with levels higher in males than in females. levels of p wer ... | 2010 | 19782759 |
| tumor volume, tumor percentage involvement, or prostate volume: which is predictive of prostate-specific antigen recurrence? | to compare the effects of tumor volume (tv), tumor percentage involvement (tpi), and prostate volume (pv) on prostate-specific antigen (psa) recurrence (psar) after radical prostatectomy (rp). | 2010 | 19819532 |
| a phase ii trial of neoadjuvant capecitabine combined with hyperfractionated accelerated radiation therapy in locally advanced rectal cancer. | preoperative treatment of rectal cancer with combined chemotherapy and radiation therapy has become a widely accepted strategy. the current challenge is to improve outcomes whereas minimizing morbidity and maximizing the potential for a sphincter sparing procedure. this study sought to evaluate the safety and efficacy of a combination of 2 novel approaches-accelerated, hyperfractionated radiation therapy and twice daily oral capecitabine. | 2010 | 19823074 |
| empty sella and primary autoimmune hypothyroidism. | in order to assess the association between empty sella (es) and primary autoimmune hypothyroidism, and the possibility of a common pathogenesis. we retrospectively studied all patients with presumed es diagnosed in the last 20 years, most of whom were treated by our endocrinology department. subjects with a known etiology were excluded. incomplete records or those with a doubtful diagnosis were also excluded. a total of 56 subjects were included in the study. es was diagnosed by pituitary mri. t ... | 2010 | 19823763 |
| impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients. | in 2001, we presented a cox regression model that is able to predict survival of the newly diagnosed patient with head and neck squamous cell carcinoma (hnscc). this model is based on the tnm classification and other important clinical variables such as age at diagnosis, sex, primary tumor site, and prior malignancies. we aim to improve this model by including comorbidity as an extra prognostic variable. accurate prediction of the prognosis of the newly diagnosed patient with head and neck cance ... | 2010 | 19827120 |
| modeling eeg fractal dimension changes in wake and drowsy states in humans--a preliminary study. | aim of this preliminary study was to examine and compare topographic distribution of higuchi's fractal dimension (fd, measure of signal complexity) of eeg signals between states of relaxed wakefulness and drowsiness, as well as their fd differences. the experiments were performed on 10 healthy individuals using a fourteen-channel montage. an explanation is offered on the causes of the detected fd changes. fd values of 60s records belonging to wake (hori's stage 1) and drowsy (hori's stages 2-4) ... | 2010 | 19822155 |
| a randomized clinical trial of thermoplastic retainer wear. | the purpose of this study was to determine whether thermoplastic retainers need to be worn full-time for a limited period or whether part-time wear from the outset is adequate to maintain tooth position, arch form, and occlusion. this study was a randomized clinical trail, conducted in a district general hospital. sixty-two participants were enrolled in the study. group 1, full-time wear, consisted of 30 patients (12 males and 18 females, aged 13.6 +/- 1.5 years) and group 2, part-time wear, 32 ... | 2010 | 19828592 |
| structure of the small outer capsid protein, soc: a clamp for stabilizing capsids of t4-like phages. | many viruses need to stabilize their capsid structure against dna pressure and for survival in hostile environments. the 9-kda outer capsid protein (soc) of bacteriophage t4, which stabilizes the virus, attaches to the capsid during the final stage of maturation. there are 870 soc molecules that act as a "glue" between neighboring hexameric capsomers, forming a "cage" that stabilizes the t4 capsid against extremes of ph and temperature. here we report a 1.9 a resolution crystal structure of soc ... | 2010 | 19835886 |
| laser evoked potentials in amyotrophic lateral sclerosis. | the pathophysiological mechanism of the pain in als is still unclear. the aim of the study was to evaluate the laser evoked potentials (leps) in als patients in relation to their clinical features. twenty-four als patients were selected. pain features were assessed and their intensity was measured by a 0-10 vas. leps were recorded in all patients and in 23 healthy subjects. the dorsum of both hands was stimulated, at laser stimuli intensity of 7.5 w, with 10s inter-stimulus interval and 25 ms du ... | 2010 | 19836030 |
| impact of android overweight or obesity and insulin resistance on basal and postprandial sr-bi and abca1-mediated serum cholesterol efflux capacities. | since android overweight/obesity and insulin resistance are independent risk factors for cardiovascular disease, we investigated their impact on basal and postprandial scavenger receptor bi (sr-bi) and atp binding cassette transporter a1 (abca1)-mediated serum cholesterol efflux. twelve android overweight to obese and 9 normal weight controls women underwent body composition analysis by dual energy x-ray absorptiometry, a euglycemic hyperinsulinemic clamp, and an oral fat load with blood samplin ... | 2010 | 19837407 |
| potentially pathogenic acanthamoeba isolated from a hospital in brazil. | studies on free-living amoebae (fla), has been increased in recent years, especially related to the genus acanthamoeba, because these organisms are widely found in the environment. the present work isolated and characterized this organism from biofilms and dust in hospital environment. 135 samples were collected in 15 different environments in a hospital at the south of brazil. thirty-one (23%) isolates were identified as morphologically belonging to the acanthamoeba genus and 10 of these were s ... | 2010 | 19841975 |
| immediate microsurgical reconstruction after tumor ablation predicts survival among patients with head and neck carcinoma. | the purpose of this study was to examine whether or not immediate microvascular free flap reconstruction influences survival among treated patients suffering from oral squamous cell carcinoma (oscc), controlling for demographic, clinical, and tumor characteristics. | 2010 | 19841982 |
| exploitation of a new flagellatropic phage of erwinia for positive selection of bacterial mutants attenuated in plant virulence: towards phage therapy. | to isolate and characterize novel bacteriophages for the phytopathogen, erwinia carotovora ssp. atroseptica (eca), and to isolate phage-resistant mutants attenuated in virulence. | 2010 | 19674185 |
| study of the transport of thyroid hormone by transporters of the slc10 family. | transport of (sulfated) iodothyronines across the plasma membrane is required for their intracellular metabolism. rat na(+)/taurocholate cotransporting polypeptide (ntcp; slc10a1) has been identified as an important transporter protein. we demonstrate that among the 7 members of the solute carrier family slc10, only human slc10a1 mediates sodium-dependent transport of the iodothyronine t4 and iodothyronine sulfates t3s and t4s. in contrast to slc10a2-7, cells co-expressing slc10a1 and the deiodi ... | 2010 | 19682536 |
| impact of demographics, tumor characteristics, and treatment factors on swallowing after (chemo)radiotherapy for head and neck cancer. | this prospective study evaluated the impact of patient demographics, tumor characteristics, and radiotherapy treatment on swallowing before and after radiotherapy or chemoradiotherapy. | 2010 | 19691115 |
| detailed examination of lymph nodes improves prognostication in colorectal cancer. | up to 30% of stage ii patients with curatively resected colorectal cancer (crc) will develop disease recurrence. we evaluated whether examination of lymph nodes by multilevel sectioning and immunohistochemical staining can improve prognostication. lymph nodes (n = 780) from 36 crc patients who had developed disease recurrence (cases) and 72 patients who showed no recurrence of disease for at least 5 years (controls) were analyzed. sections of 4 levels at 200-microm interval were immunohistochemi ... | 2010 | 19676050 |
| prevalence of anterior pituitary dysfunction in patients following traumatic brain injury in a german multi-centre screening program. | we determined the prevalence of anterior pituitary dysfunction in a multi-centre screening program across five german endocrine centres in patients rehabilitating from tbi (gcs<13). | 2010 | 19691014 |
| definitive radiotherapy for squamous cell carcinoma of the anal canal. | to review the outcomes of definitive radiotherapy (rt) alone or combined with chemotherapy (ct) in the treatment of squamous cell carcinoma of the anal canal. | 2010 | 19704368 |
| evaluation of small ligand-protein interaction by ligation reaction with dna-modified ligand. | a method for the evaluation of interactions between protein and ligand using dna-modified ligands, including signal enhancement of the dna ligation reactions, is described. for proof of principle, a dna probe modified by biotin was used. two dna probes were prepared with complementary sticky-ends. while one dna probe was modified at the 5'-end of the sticky-end, the other was not modified. the probes could be ligated together by t4 dna ligase along the strand without biotin modification. however ... | 2010 | 19705069 |
| relationships of serum free thyroxine and erythrocyte measures in euthyroid hfe c282y homozygotes and control subjects: the heirs study. | hemoglobin (hb) levels and mean corpuscular volume (mcv) are abnormal in some persons with hemochromatosis or thyroid disorders. we sought to determine whether serum free thyroxine (t4) affects erythrocyte measures in euthyroid adults with or without c282y homozygosity. we evaluated 488 white hfe c282y homozygotes and controls (no hfe c282y or h63d; normal serum iron measures) identified in screening; we excluded those with thyroid disorders, anemia, erythrocytosis, or serum ferritin (sf) <34 pm ... | 2010 | 19706067 |
| molecular biology and biotechnology of bacteriophage. | the development of the molecular biology of bacteriophage such as t4, lambda and filamentous phages was described and the process that the fundamental knowledge obtained in this field has subsequently led us to the technology of phage display was introduced. | 2010 | 19714316 |
| lack of a co-promotion effect of 60 hz circularly polarized magnetic fields on spontaneous development of lymphoma in akr mice. | the present study was conducted to investigate the possible effect of 60 hz circularly polarized magnetic fields (mfs) as promoters of genetically initiated lymphoma in akr mice. one hundred sixty female animals were divided into four different groups. they were exposed to four different intensities of circularly polarized mfs. animals received exposure to 60 hz circularly polarized mf at field strengths (rms-value) of 0 microt (sham control, t1, group i), 5 microt(t2, group ii), 83.3 microt (t3 ... | 2010 | 19722221 |
| assessment of left ventricular systolic asynchrony in patients with clinical hypothyroidism. | hypothyroidism has a large number of adverse effects on the cardiovascular system such as impaired cardiac contractility. left ventricular (lv) asynchrony is defined as loss of the simultaneous peak contraction of corresponding cardiac segments. | 2010 | 19725846 |
| short oligonucleotide tandem ligation assay for genotyping of single-nucleotide polymorphisms in y chromosome. | we propose a novel universal methodology, short oligonucleotide tandem ligation assay (sotla), for snp genotyping. sotla is based on using a tandem of short oligonucleotide (tso) probes consisting of three fragments: the core oligonucleotide and two flanking oligomers, one of which is immobilized onto a solid support and another one contains the biotin label. tso is self-associated on a complementary dna template, forms the complex containing two nicks, which are efficiently ligated with dna lig ... | 2010 | 19728184 |
| antimicrobial peptides derived from goose egg white lysozyme. | peptide fragments possessing antimicrobial activity were obtained by protease digestion of goose egg white lysozyme. digested peptide purified from rp-hplc which showed no lysozyme activity exhibited bactericidal activity toward gram-negative and gram-positive bacteria. lc/ms-ms and automated edman degradation revealed the amino acid sequence to be thr-ala-lys-pro-glu-gly-leu-ser-tyr. this sequence corresponds to amino acid positions 20-28, located at the n-terminal outer part of goose lysozyme. ... | 2010 | 19737628 |
| human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in lncap cells. | the tumor microenvironment is important for progressive and metastatic disease. | 2010 | 19747763 |
| childhood sexual abuse and hypothalamus-pituitary-thyroid axis in postpartum major depression. | the aim of this study was to investigate the association between early life events in women with postpartum major depression and concomitant hypothalamus-pituitary-thyroid axis disturbances (hptd), thyroid dysfunction or presence of thyroid antibodies. | 2010 | 19740549 |
| cholesterol addition protects membrane intactness during cryopreservation of stallion sperm. | addition of cholesterol to sperm membranes improved equine sperm stability during semen cryopreservation; however, it also reduced in vivo fertility. the objective of the present study was to determine the effects of adding cholesterol to stallion sperm prior to freezing, and subsequently removing it from frozen-thawed sperm. semen from 12 stallions was subjected to four treatments: (t1) control, semen was diluted with kenney extender, centrifuged, and resuspended to 100 x 10(6)spermatozoa/ml in ... | 2010 | 19758774 |