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incidence of cutaneous diphtheria in bangladesh.corynebacterium diphtheriae (c. diphtheriae) was isolated from 23 (7%) skin ulcers out of 327 cases studied. eight (33%) of the 23 positive cases belonged to the age group of 6 to 10 years. of the 19 strains of c. diphtheriae typed, 18 (95%) were gravis and of which 14 (77%) were toxigenic. more than 90% of the c. diphtheriae positive ulcer cases had serum anti-toxin level at or above the protective level as against 49% of control. no diphtheria bacilli were isolated from throat of any of the sk ...19836426456
counterimmunoelectrophoresis for identification of toxinogenesis in corynebacterium diphtheriae. 19836424628
[purulent otitis media caused by corynebacterium diphtheriae]. 19836887703
reclassification of corynebacterium pyogenes (glage) in the genus actinomyces, as actinomyces pyogenes comb.nov.corynebacterium pyogenes (glage) differs to such an extent from the type species of corynebacterium, corynebacterium diphtheriae (lehmann and neumann), that it cannot be retained in this genus. numerical phenetic and chemical data indicate a close relationship between corynebacterium pyogenes and the species actinomyces bovis (harz). it is proposed that corynebacterium pyogenes be reclassified in the genus actinomyces, as actinomyces pyogenes (glage) comb.nov.19826750042
diphtheria toxin and related proteins: effect of route of injection on toxicity and the determination of cytotoxicity for various cultured cells.the effect of route of injection on the toxicity of intact diphtheria toxin, cross-reacting material (crm45), and diphtherial fragment a was compared in several animal species. by ordinary routes of injection, neither crm45 nor fragment a was toxic, even in species for which 0.1 micrograms of toxin/kg of body weight was lethal. after intracerebral injection, however, small amounts of crm45 led to paralysis and death, even in mice and rats--species that are resistant to toxin administered intrave ...19826798133
the exotoxins of corynebacterium ulcerans.the exotoxins produced by ten strains of c. ulcerans (two human, six bovine and two equine) have been studied. on the criteria of toxin-antitoxin neutralisation and immunoprecipitation tests using highly specific diphtheria and c. ovis antitoxins with crude toxic filtrates, (nh4)2so4 concentrates, and partially purified chromatographic preparations of these, together with the presence or absence of inhibition of the action of staphylococcal beta-haemolysin, and the reaction produced when injecte ...19826801113
[accelerated identification method for corynebacterium diphtheriae].a method for rapid isolation of c. diphtheriae and determination of its biovar is proposed. the method consists in the inoculation of the material under study into 5% blood agar, the determination of cystinase in the modified pisou medium prepared from agar d with sodium hyposulfite added and the fermentation of starch in dishes with serum starch agar. the proposed method allows one to reduce the time necessary for the identification of c. diphtheriae by 18 hours.19826805177
preliminary crystallographic investigation of the protein toxin from corynebacterium diphtheriae.crystals of diphtheria toxin have been obtained in vapor diffusion experiments from concentrated solutions of potassium tartrate as the precipitating agent. the crystals are trigonal with unit cell dimensions a = b = 97.90 a and c = 100.30 a. the space group is p31 12 or its enantiomorph. the unit cell contains 6 molecules of molecular weight 62,000 with 1 molecule/asymmetric unit. the crystals diffract beyond 2.8 a resolution and are able to withstand more than 100 h of x-ray exposure. the comp ...19826806258
burns and corynebacterium diphtheriae. 19826807498
production of corynebacterium diphtheriae toxin in a bubble column fermentor. 19826807989
the lowly diphtheriod: nondiphtheria corynebacterial infections in humans. 19826814070
fatal diphtheria--wisconsin. 19826817057
[isolation and identification of corynebacterium, listeria and erysipelothrix]. 19826817545
fatty acid composition of some mycolic acid-containing coryneform bacteria.the fatty acid profiles of 74 strains of mycolic acid-containing coryneform bacteria were examined by gas-liquid chromatography. all of the strains contained major amounts of straight-chain and monounsaturated fatty acids although some also possessed substantial amounts of 10-methyloctadecanoic acid. iso- and anteiso-branched acids were not present. five distinct fatty acid patterns were evident: (i) corynebacterium diphtheriae, c. pseudotuberculosis and 'c. ulcerans' strains contained major amo ...19826818327
biotypes, toxigenicity and antibiotic sensitivity of corynebacterium diphtheriae. 19826819337
isolation of c. diphtheriae gravis in leeds. 19826821100
diphtheria of the eye. a forgotten diagnosis. 19826821237
[survey on corynebacterium diphtheriae carriers and susceptibility to schick's toxin in diphtheria contacts]. 19826821284
tetracycline resistance of corynebacterium diphtheriae isolated from diphtheria patients in jakarta, indonesia.of 133 corynebacterium diphtheriae isolates from diphtheria patients in jakarta, indonesia, 86% were resistant to greater than or equal to 32 micrograms of tetracycline per ml. all isolates were sensitive to ampicillin, cephalothin, chloramphenicol, clindamycin, penicillin, erythromycin, and kanamycin. the general resistance of c. diphtheriae to tetracycline in this part of indonesia appears to be unique compared with resistance reported in studies done in other parts of the world.19826808914
[bacterial endocarditis due to corynebacterium diphtheriae (author's transl)].a case of bacterial endocarditis with unusual features in a 5 year-old boy is reported. there was no underlying heart disease or provocating factor. the organism was a non toxigenic corynebacterium diphtheriae which was difficult to classify. it appeared to be close to the jk group of corynebacterium described by the center for disease control and considered as possibly responsible for severe infections. however, it was sensitive to penicillin. the course of the disease was complicated by the de ...19826808967
group jk diphteroids sepsis in a leukaemic patient. 19826812335
corynebacterium diphtheriae endocarditis in an adult with congenital cyanotic heart disease. a case report.corynebacterium diphtheriae is a very rare cause of both septicaemia and endocarditis. a case of endocarditis due to c. diphtheriae is reported and the clinical features and course of this case and other similar cases previously reported in the literature are compared.19827071685
analysis of mycolic acids from a group of corynebacteria by capillary gas chromatography and mass spectrometry.the cell wall of leprosy-derived corynebacteria (a group of 'diphtheroids' isolated from human leprosy lesions and patients' blood) was previously shown to contain, in addition to peptidoglycan and arabinogalactan, mycolic acids. these alpha-branched beta-hydroxy fatty acids were attributed to the corynomycolic group, according to their rf in monodimensional thin-layer chromatography. in the present work, mycolic acids from leprosy-derived and reference corynebacteria have been fractionated by m ...19827106128
[trial of using a semiliquid tindale's medium for increasing the yield of corynebacterium diphtheriae]. 19826174796
[use of a binocular stereoscopic microscope to select colonies of c. diphtheriae]. 19826180244
[corynebacterium endocarditis. diagnostic difficulties (author's transl)].the authors report a case of endocarditis due to corynebacterium diphtheriae. the bacteriological study is difficult since this micro-organism can be undistinguishable from a saprophytic diphtheroid. the observed case is compared to previously published observations. all have in common the great severity of the illness, and the high mortality rate. despite the clinical symptoms and the cerebrospinal fluid (csf) abnormalities, meningitic involvement could not be demonstrated.19826277011
restriction endonuclease map of the nontoxigenic corynephage gamma c and its relationship to the toxigenic corynephage beta c.clear-plaque-forming mutant gamma tox- corynephages were isolated independently from nontoxigenic lysogenic corynebacterium diphtheriae strains c7s(gamma tox-) and c4(gamma tox-). a physical map was constructed by using restriction endonucleases bamhi, ecori, hindiii, and kpni. a comparison of nontoxigenic gamma c with toxigenic corynephage beta c revealed large areas of homology, including common regions for cohesive ends (cos) and attachment sites (att). localization of the att sites on the be ...19826283169
[initial studies for the development of processes in the production of bacterial vaccines by agitator culture]. 19816278654
[bacteriological diagnosis of diphtheria (minimal diagnosis)]. 19816212802
restriction map of corynebacteriophages beta c and beta vir and physical localization of the diphtheria tox operon.the bamhi, ecori, hindiii, and kpni restriction endonuclease maps of corynebacteriophage beta c and beta vir were constructed. beta vir appeared to be identical to beta c, except for an approximate 1-kilobase deletion that removed a bamhi site, two kpni sites, and three ecori restriction sites. the diphtheria tox operon was located by hybridizing in vitro 32p-labeled tox messenger ribonucleic acid to blots of endonuclease-digested beta deoxyribonucleic acids. the messenger ribonucleic acid probe ...19816270058
physical mapping of beta-converting and gamma-nonconverting corynebacteriophage genomes.deoxyribonucleic acids (dnas) from wild-type and mutant strains of beta-converting and gamma-nonconverting corynebacteriophages were isolated and physically characterized. the data obtained from dna heteroduplexes, restriction enzyme banding profiles, and restriction maps reinforce the conclusion that beta and gamma phages are very closely related. the major physical differences seen in the dna heteroduplexes are a small substitution bubble and one or two insertions which are present on the gamm ...19816270059
genetic elements novel for corynebacterium diphtheriae: specialized transducing elements and transposons.it was shown in an accompanying paper (buck and groman, j. bacteriol. 148: 131-142, 1981) that gamma-tsr-1 phage stocks produced by heat induction of lysogens are a mixture of two phages which differ in the content of their deoxyribonucleic acid (dna). this difference is evidenced by the appearance of "heterogeneous" (het) fragments in restriction enzyme digests of gamma-tsr-1 phage dna. it was estimated that 20 to 80% of the phage in these lysates produced het fragments. the appearance of het f ...19816270060
identification of deoxyribonucleic acid restriction fragments of beta-converting corynebacteriophages that carry the gene for diphtheria toxin.deoxyribonucleic acid fragments bearing the gene for diphtheria toxin have been identified in restriction enzyme digests of deoxyribonucleic acids from beta-converting and gamma-nonconverting corynebacteriophages. a combination of physical and genetic evidence has established that the bam hi band c fragment of beta phage deoxyribonucleic acid, which carries the specific phage attachment site (buck and groman, j. bacteriol. 148:131-142, 1981), also carries most, and probably all, of the gene for ...19816270061
complications of diphtheria seen during the 1978 outbreak in khartoum.twenty-nine cases of complicated diphtheria infection occurring during an epidemic in khartoum are reviewed. the organism was a corynebacterium diphtheriae subsp. gravis with an unusual property of fermenting sucrose. eighteen patients were detected during prospective follow-up, where as 11 presented initially with a complication. complications were mostly seen among pre-school children (65.5%). a routine immunization course had been completed in only two of the patients. neurological complicati ...19816185059
corynebacterium diphtheriae septicemia.this report describes the case of a patient with chronic lymphocytic leukemia in whom septicemia caused by a nontoxigenic strain of corynebacterium diphtheriae developed. numerous abscesses were present in sections of liver and spleen taken at autopsy. the case is discussed, and the literature on infections caused by organisms of the genus corynebacterium is briefly reviewed.19817223724
[evaluation of the fluorescence for the identification of corynebacterium diphtheriae in patients with diphtheria]. 19816808630
chromogenic detection of antigen in bacteriophage plaques: a microplaque method applicable to large-scale screening.we have developed a simple and rapid (24 h) enzyme-linked immuno-detection method to screen for rare antigen-positive phage among large numbers of antigen-negative ones. horse-radish peroxidase-antibody conjugate, incorporated into the soft agar layer of a plaque assay system, is precipitated locally by antigen produced during plaque formation, and is detected by standard chromogenic methods. the method has been used to screen plaques of bacteriophage beta tox+ for the presence of diphtheria tox ...19816790347
appendix: a model of plaque formation.equations describing plaque formation in soft agar have been based on certain simplifying assumptions, for which data are presented. the derived equations permit one to calculate (i) average plaque size as a function of the initial density of indicator cells (do), (ii) the number of cells lysed per plaque as a function of do, and (iii) the cumulative number of cells lysed at various stages of plaque development. the calculated values agree well with those determined experimentally.19816790348
[diphtheria and tetanus antibodies in children and young adults (author's transl)].diphtheria and tetanus antibodies were determined in a random sample of 635 test persons of 1 to 25 years of age via the passive haemagglutination test. using sera and immunoglobulins standardized for protective capacity, titres were expressed as international units (iu). titres greater than or equal to 0.01 iu/ml diphtheria antitoxin were detected in 96% of children (1-17 years, n = 70), in 79% of adults aged 18-22 (n = 397), in 68% of adults aged 23-25 (n = 168); tetanus antitoxin was found in ...19816791906
[microflora of the gastric and duodenal mucosa in peptic ulcer]. 19816792417
[epidemiological surveillance in diphtheria infections]. 19816797161
mutants of corynebacterium diphtheriae pw8 that produce toxin in medium with excess iron.two mutants that produce toxin in medium with excess iron were isolated from the pw8 strain of corynebacterium diphtheriae. these mutants produced as much toxin in medium containing excess iron (3 mug of fe2+ per ml) as did the parent pw8 strain in iron-depleted medium, and they will be very useful for easy production of toxin.19816797351
regulation of toxinogenesis in corynebacterium diphtheriae. i. mutations in bacteriophage beta that alter the effects of iron on toxin production.diphtherial toxin is produced in maximal yields by corynebacterium diphtheriae (c7(beta tox+) only when iron is present in growth-limiting amounts. toxin production is markedly decreased under high-iron conditions. we studied the role of the bacteriophage beta genome in this apparent regulation of toxin production by iron. using a passive immune hemolysis assay to detect toxin antigen production in individual plaques, we identified rare phage mutants that were toxinogenic in high-iron medium. ly ...19816785449
regulation of toxinogenesis in corynebacterium diphtheriae. ii. genetic mapping of a tox regulatory mutation in bacteriophage beta.the structural gene for diphtherial toxin is present in corynebacteriophage beta. previous studies located several point mutations within the tox locus and determined the orientation of transcription of the toxin structural gene. the production of maximal quantities of toxin by corynebacterium diphtheriae c7(beta) occurs only when the bacteria are iron deficient. mutations in phage beta can affect this control of toxin production by iron. the tox-201 mutation regulates expression of the toxin st ...19816785450
diphtheroid endocarditis after electrolysis. 19816786539
[varieties of diphtheria: microbiological diagnosis and epidemiological observations (author's transl)].following several cases of diphtheria an epidemiological investigation was made in and around aachen. a total of 1458 throat and nose smears were examined for various corynebacteria species. other than in two patients who had diphtheria, toxin-producing corynebacterium diphtheriae was demonstrated in only one person who had been in immediate contact with them. of a total of 150 corynebacteria of different species which were isolated, two further isolates proved to be non-toxin-producing diphther ...19816786851
corynebacterium diphtheriae in surgical wounds. 19816786985
[antigenic characteristics of various toxigenic and non-toxigenic strains of c. diphtheriae var. gravis]. 19816787823
esculin hydrolysis by gram positive bacteria. a rapid test and it's comparison with other methods.a number of bacteria hydrolyze esculin enzymatically to esculetin. this characteristic is used by taxonomists and clinical microbiologists in the differentiation and identification of bacteria, especially to distinguish lance-field group d streptococci from non-group d organisms and listeria monocytogenes from morphologically similar erysipelothrix rhusipoathiae and diphtheroids. conventional methods used for esculin hydrolysis require 4--48 h for completion. we developed and evaluated a medium ...19816783825
infective endocarditis due to corynebacterium diphtheriae: report of a case and review of the literature. 19816893847
[epidemiologic possibilities for phage typing diphtheria bacteria isolated from patients and carriers in the azerbaijan ssr]. 19816453490
cotranslational secretion of diphtheria toxin and alkaline phosphatase in vitro: involvement of membrane protein(s).crude messenger ribonucleic acid fractions isolated from corynebacterium diphtheriae and escherichia coli were translated in an e. coli in vitro protein-synthesizing system and yielded precursors of the secreted proteins diphtheria toxin and alkaline phosphatase, respectively. addition of inverted e. coli inner membrane vesicles to the system during the initial stages of translation resulted in the intravesicular segregation of mature diphtheria toxin and alkaline phosphatase. outer membrane ves ...19806988404
counter immunoelectrophoresis for rapid testing of toxin producing corynebacterium diphtheriae. 19806785212
immunization status of school children. 19806785226
profile analysis of total mycolic acids from skin corynebacteria and from named corynebacterium strains by gas-liquid chromatography and gas-liquid chromatography/mass spectrometry.gas-liquid chromatography (g.l.c.) was investigated as a potential tool in the classification and identification of cornyebacterium strains isolated from human skin, on the basis of the g.l.c. profile of the trimethylsilyl derivatives of their mycolic acid methyl esters. the g.l.c. patterns of five skin corynebacteria were compared with those of reference strains corynebacterium diphtheriae pw8 and corynebacterium xerosis nctc 9755 and nctc 7929. further compositional information was obtained by ...19806767807
[natural variability of mycobacteria and related organisms]. 19806768404
toxicity of diphtheria toxin-related proteins produced by suppression of nonsense mutations.the mr = 62,000 diphtheria toxin-related proteins produced from the suppression of nonsense mutations within the tox gene of corynephage beta were purified by affinity chromatography. except for the toxin 111-sup2-62, the mr = 62,000 polypeptides were found to have the same specific toxicity as does wild type toxin. 111-sup2-62 was found to have a prolonged lag period prior to the onset of inhibition of protein synthesis and adp-ribosylation of elongation factor 2. 111-sup2-62 differs from wild ...19806776122
superinfection exclusion by heteroimmune corynebacteriophages.superinfection of corynebacterium diphtheriae c7(beta) by heteroimmune phage gamma is productive, whereas superinfection by gamma-bin mutants is for the most part nonproductive. exclusion of gamma-bin phage occurred after its dna had penetrated and was partially expressed in the heteroimmune lysogen. all of the infected cells were killed, and lysis was observed. the beta inhibitor causing exclusion was produced during the prophage state and appeared to be distinct from immune repressor. the abil ...19806776290
[diphtheria immunity and the epidemiological situation in the kielce district]. 19806776591
[comparative evaluation of method of preparing diphtheria antibody diagnostic media using erythrocytes]. 19806778024
[protective somatic antigen of corynebacterium diphtheriae].deoxycholate c. diphtheriae extract was separated into fractions differing in the size of their molecules. correlation between the molecular weight of each fraction, its specific protein content and its immunogenicity was observed. the high-molecular fraction (mol. wt. exceeding 300,000 daltons) was shown to be the protective somatic antigen of c. diphtheriae.19806778025
radioimmunoassay of arthrobacter neuraminidase: applications to catalytic and taxonomic studies. 19806779664
immunogenic correlation between cross-reacting material (crm197) produced by a mutant of corynebacterium diphtheriae and diphtheria toxoid.the in vivo immunizing potency of diphtheria toxoid and formalin-treated corss-reacting material (crm197, a nontoxic mutant protein) was compared in guinea pigs. major antigenic differences between the two untreated proteins were also tested in rats. the results showed that diphtheria toxoid and crm197 were equally effective immunogens, but only if the latter was treated with formalin in the same concentration (0.7% vol/vol) was that of the toxoid. formalin treatment rendered the antigens more r ...19806780629
simple procedure for purification of diptheria toxin and separation of its fragments by hydrophobic chromatography. 19806781376
[immunity to diphtheria in advanced cancer patients].in expectation of a possible anticancer treatment with diphtheria toxin, the antidiphtheria immunity has been tested on 65 advanced cancerous patients. the test has been carried out by schick's test and by blood antibodies' dosage effected by a process "in vivo" on the depilated skin of the new zealand rabbit. the results show that about the 30% of these patients has no antidiphtheria immunity. the remaining 70% has antidiphtheria immunity, even if in half cases the antibody level is lower than ...19806783052
an improved method for obtaining homogeneous and stable suspension of c. diphtheriae for bacterial agglutination. 19806788014
slide agglutination assay in the c. diphtheriae identification. 19806788015
diphtheria in jordan: a diminishing yet important paediatric disease.twenty-seven cases of diphtheria (15 male, 12 female) admitted over a 2-year period, 1977-1978, at the jordan university hospital were reviewed. the majority were admitted during autumn and were in the 2-9-year age group. eleven patients were not vaccinated and six were questionably vaccinated; of these seven died. in 10 patients who were partially or completely vaccinated, only one died. antitoxin was given to 23 patients at varying intervals after the onset of the disease. no antitoxin was giv ...19807381985
[tonsils in diphtheria and the corynebacterium diphtheriae carrier state].investigations of 16 archive autopsy observations of diphtheria of the fauces confirmed bacteriologically revealed that corynebacteria diphtheriae multiplied mainly on the surface of the mucous membrane. fibrinous inflammation on the tonsillar surface is most typical for this agent. in all cases with manifestations of acute inflammation the lesion was caused by c. diphtheriae in combination with other bacteria, most frequently streptococci. the latter were harboured deep in the tonsills and caus ...19807406725
diphtheria: studies on the biology of an infectious disease. 19806813290
[demonstration of a method of passive microhemagglutination for the titration of antidiphtheria antibodies]. 19806821476
[growth stimulator for diphtheria bacteria]. 19806157893
[use of the aggregate hemagglutination method for determining cholera vibrio neuraminidase].the suitability of the aggregate hemagglutination test for neuraminidase determination in biological fluids has been evaluated. this test allows one to determine neuraminidase at a concentration of 2--4 mg/ml. the sensitivity of this test is more than 2 orders higher than that of gel diffusion technique and the thiobarbituric assay. the test has revealed that neuraminidase produced by vibrio cholerae is not immunologically related to other kinds of neuraminidase produced by corynebacterium dipht ...19806160701
diphtheria carriers in manchester: simultaneous infection with toxigenic and non-toxigenic mitis strains.a toxigenic strain of corynebacterium diphtheriae mitis was isolated from a 10-week-old baby with membranous tonsillitis, and over the next 6 months thirty-nine symptom-free carriers of nitrate-positive mitis strains were found. all carriers were cleared by 14 days' treatment with erythromycin, though several relapsed after a 5-day course. four contacts carried both toxigenic and non-toxigenic mitis strains; epidemiological evidence and phage studies suggest that these had a common origin. these ...19806101751
toxigenic and non-toxigenic corynebacterium diphtheriae. 19806102650
the search for antiviral agents among corynebacteria.extracts of strains of corynebacterium diphtheriae var. mitis avirulent, c. hofmannii, c. xerosis, c. parvum and an unidentified corynebacterium species were tested for antiviral activity against laboratory strains of echovirus type 11, adenovirus type 2 and vaccinia, and a recent isolate of herpes simplex virus. unlike a previous study, no appreciable antiviral activity was detected in the extracts tested19806108068
precursor in cotranslational secretion of diphtheria toxin.by extracellular labeling of peptides of intact corynebacterium diphtheriae, followed by fractionation of the cells and chain completion by isolated polysomes, it is shown that diphtheria toxin is formed and secreted cotranslationally by membrane-bound polysomes; free polysomes from none. moreover, when the chains on these polysomes were completed in vitro, in the absence of membrane they were found to include not only diphtheria toxin of a molecular weight of 62,000, but also a larger precursor ...19806243620
plasmids in corynebacterium diphtheriae and diphtheroids mediating erythromycin resistance.plasmids were isolated from erythromycin-resistant corynebacterium diphtheriae and skin coryneforms. six erythromycin-resistant c. diphtheriae strains, isolated from cutaneous lesions, all contained a 9.5-megadalton (mdal) plasmid. loss of resistance was associated with the deletion of a 1-mdal segment from the plasmid or, less frequently, with loss of the plasmid. two erythromycin-resistant diphtheroids were isolated from similar skin lesions. one contained a 38-mdal plasmid that was lost in th ...19806255866
immunological surveys of diphtheric antitoxic antibodies in some african and asian countries.immunological surveys of diphtheric antitoxic antibodies confirmed the existence of a high circulation of corynebacterium diphtheriae in some african and asian countries. the high immunity level in early childhood confirms the well known fact that other forms of diphtheria, in particular the cutaneous forms, participate in the formation of antitoxic antibodies. immunological surveys can determine relatively exactly the extent of risk of infection in the separate age groups and thus delimit the r ...19806447173
some aspects of phage typing of diphtheria microbes in epidemiological practice. 19806450800
studies on the inhibitory effects of zinc heptanoate on microorganisms.inhibitory effect of zinc heptanoate was observed on different cultures of bacteria and fungi. growth of all the bacteria was inhibited by the compound. greatest inhibition was seen in the case of staphylococcus albus, streptococcus pyogenes, shigella dysenteriae, shigella sonnei, shigella flexneri, salmonella typhi, s. paratyphi a, s. paratyphi b, vibrio cholerae, corynebacterium diphtheriae, and e. coli whereas least inhibition was found in the case of staphylococcus aureus. in triethanolamine ...1979553835
[a leg ulcer from the tropics caused by corynebacterium diphtheriae?]. 1979104183
[use of microbial cells of corynebacterium diphtheriae for preparing a nutrient medium].nutrient media prepared on the basis of microbial cells (corynebacteria diphtheriae) proved to be no less nutrient in comparison with conventional media prepared on the full-value food products. use of diphtheria bacilli (by-products of diphtheria toxoid production) as the basis for nutrient media permitted to use up to 30% less food products for this purpose.1979105520
epidemiologic studies among amerindian populations of amazônia. i. pyoderma: prevalence and associated pathogens.pyoderma was studied among a representative sample of the residents of four remote amerindian villages, amazonas state, brazil, during july-august 1976. the overall prevalence among the 775 inhabitants examined was 11%, with little intervillage variation. when the attack rates for the entire sample population were calculated by 5-year age intervals, the 0- to 4-year-olds had the highest rate, 31%. the highest prevalence, 38%, was found among 3-year-olds. attack rates were not apparently related ...1979110164
[antibacterial immunity in diphtheria. experimental research].a number of 700 guinea pigs were immunized by parenteral route with non-toxigenic corynebacterium diphtheriae strains, then inoculated with various doses of homologous and heterologous toxigenic c. diphitheriae strains. the results showed that non-toxigenic c. diphtheriae strains confer a certain degree of protection when the challenge is done with homologous toxigenous strains, especially when not more than 500 million germs/ml are used for the challenge dose. this suggests that the carriage of ...1979111333
[heteromorphism of the corynebacteria. iii. d- (dark) and c- (clear) cell types and multiseptate specimens].a population of corynebacterium diphtheriae may consist of cells with accented (osmiophilic) cytoplasm (cells of the "dark" type, or d type) and cells with cytoplasm having no pronounced osmiophilic properties (cells of the "clear" type, or c type). the divergence of the population into cells of the d and c types occurs at the stage of cell division, the original mother cell being able to divide into 2 or more individual cells belonging to different types (elongated multiseptate cells). at the s ...1979111440
occurrence of 3-oxo-acyl groups in the 6,6'-diesters of alpha-d-trehalose. new glycolipids related to cord factor from corynebacterium diphtheriae. 1979111936
[a tropical ulcus cruris caused by corynebacterium diphtheriae?]. 1979112483
[interrelationship of toxin formation with proteolytic enzyme synthesis in the process of cultivating diptheria microorganisms].for the first time the synthesis of proteolytic enzymes by corynebacterium diphtheriae has been shown to precede the process of toxin formation. the process of controlling the proteolytic activity of enzymes seems to be a suitable basis for the evaluation of toxin formation in mathematically planned experiments with strictly controlled tasks.1979112807
[appearance in domestic animals of corynebacterium diphtheriae and other corynebacterium strains pathogenic for man]. 1979113847
activity of penicillin, erythromycin, and cephalosporins against isolates of corynebacterium diphtheriae from cutaneous lesions. 1979114513
isolation of a cured strain from corynebacterium diphtheriae pw8.a nonlysogenic, non-toxinogenic strain was isolated from the pw8 strain of c. diphtheriae by two-step ultraviolet induction. this strain was lysed by phages derived from the pw8 strain but not by beta phages from the c7(beta) strain. when this cured strain was lysogenized with phages from the pw8 strain, toxin production by the resulting lysogens was about a half or a quarter of that of the parent strain pw8.1979115787
characterization of a screening test for diphtherial toxin antigen produced by individual plaques of corynebacteriophages.a passive immune hemolysis assay has been developed to detect diphtherial toxin produced in individual plaques of tox+ corynebacteriophages. this assay permits rapid screening of large numbers of corynebacteriophages for their ability to code for diphtherial toxin or related antigens. the specificity of the assay and its potential usefulness for genetic studies of toxinogenesis have been demonstrated with well-characterized tox+ and tox- laboratory strains of corynebacteriophages.1979115898
[effect of the degree of culture aeration on diphtheria toxin production and growth of 3 variants of corynebacterium diphtheriae pw 8]. 1979116098
erythromycin and clindamycin resistance in corynebacterium diphtheriae from skin lesions.erythromycin- and clindamycin-resistant corynebacterium diphtheriae isolates were recovered from skin lesions. resistance to erythromycin and clindamycin was induced by a subinhibitory concentration (0.03 microgram/ml) of erythromycin. clindamycin (0.07 microgram/ml) was a more effective inducer of its own resistance than of erythromycin resistance. erythromycin-inducible cross-resistance to vernamycin b alpha was demonstrated in disk diffusion tests.1979117748
non-toxigenic corynebacterium diphtheriae causing subacute bacterial endocarditis: case report.this is the case report of a 13-yr-old european child from a boarding school at herberton, on the atherton tableland, who developed subacute bacterial endocarditis, with 6 blood cultures at different times growing a non-toxigenic strain of corynebacterium diphtheriae.1979118422
effect of metal ions on diphtheria toxin production.the effect of several metal ions on the production of diphtheria toxin was tested. by using the gel immunodiffusion system for detecting toxin, a wide range of metal ion concentrations was conveniently surveyed. five divalent cations, fe2+, cu2+, co2+, ni2+, and mn2+ inhibited toxin production within a range of concentrations that did not inhibit growth of the producing strain. growth and toxin production were inhibited at identical concentrations by both cd2+ and zn2+, whereas al3+ and sr2+ aff ...1979118927
[testing of a system of unidirectional serologic reactions for detection of diphtheria antigens and antibodies]. 1979106599
ige synthesis in man. ii. comparison of tetanus and diphtheria ige antibody in allergic and nonallergic children. 1979107210
bactericidal effects of anesthetics. 1979107831
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