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the place of exercise in the long-term treatment of hypertension.the antihypertensive effects of exercise have been examined in 2 randomized studies of multiple levels of activity. in 12 normal subjects, 1 month's exercise 3 times weekly lowered blood pressure (bp) and vascular resistance. there was only a slightly greater effect after 7 times/week exercise. in most subjects there was a marked reduction in noradrenaline spillover rate, a measure of sympathetic activity. exercise also improved glucose utilization and lowered plasma cholesterol. thirteen previo ...20113122065
aggressive combination therapy in the successful management of life-threatening intracranial hemorrhage in a patient with idiopathic thrombocytopenic purpura.we describe acute therapy for a 13-year-old female from panama with chronic idiopathic thrombocytopenia purpura (itp) refractory to steroids, splenectomy, vinca alkaloids, and azathioprine. she presented with neurologic deterioration from a posterior fossa intracranial hemorrhage (ich). this followed a 3-month history of severe dysfunctional uterine bleeding, progressive from menarche, which had required multiple red cell transfusions. steroid and vinblastine therapy and transfusion of 40 u of p ...20113766911
ethics of fetal brain cell transplants. 20113133017
conversion of serine to glycerate in intact spinach leaf peroxisomes: role of malate dehydrogenase.in photorespiration, leaf peroxisomes convert serine to glycerate via serine-glyoxylate aminotransferase and nadh-hydroxypyruvate reductase. we isolated intact spinach leaf peroxisomes in 0.25 m sucrose, and characterized their enzymatic conversion of serine to glycerate using physiological concentrations of substrates and coenzymes. in the presence of glycolate (glyoxylate), and nadh and nad alone or together in physiological proportions, the rate of serine-to-glycerate conversion was enhanced ...20113080957
[planned introduction and execution of the nursing process in practice. a challenge to inservice training]. 20113119931
some extra-articular manifestations of arthritis and complications of therapy. a pictorial essay.more than 100 years ago lasegue wrote, "rheumatic fever licks at the joint but bites at the heart." this truth may be expanded to include nearly every joint ailment on one hand, and nearly every organ system on the other hand. in connective tissue disorders, bleeding diasthesias and metabolic and endocrine disorders, the joint manifestations are only one part of the total picture. this article shows a few examples of cardiopulmonary, gastrointestinal, and other manifestations. a few examples of ...20113051097
editorial: idiopathic membranous nephropathy. 20114129724
hyperglycemia. a complication of chemotherapy in children. 20113162821
rocky mountain spotted fever--united states, 1987. 20113131657
[enterostoma therapy--a pilot course in the essen education center of the german nursing association]. 20113127632
impact of pharmacist intervention on oral theophylline therapy in adult inpatients.the impact of clinical pharmacy services on the utilization of oral theophylline therapy was evaluated in a ten-week study involving 138 adult inpatients. the study initially involved an independent prospective five-week audit of theophylline use, in which clinical pharmacists monitored theophylline therapy and any interventions were designed so as not to influence future actions taken by medical officers with regard to oral theophylline therapy. the second part of the study involved active inte ...20113428141
insulin resistance and very low energy diets. 20113380444
combined effects of deafferentation and de-efferentation on isthmo-optic neurons during the period of their naturally occurring cell death.we have studied the effects on the chick embryo's isthmo-optic nucleus of de-efferentation alone or in combination with deafferentation. de-efferentation was achieved by pharmacological destruction of the axonal target cells in the retina at e13, or by colchicine-blockade of axoplasmic transport in the intraocular parts of the isthmo-optic axons at e13; deafferentation was by a tectal lesion at e11 or e12. de-efferentation alone causes all the isthmo-optic neurons to die, and mostly by the "endo ...20113232850
risk of upper respiratory tract infection and malaria prophylaxis. 20113133070
surgical aspects of drug smuggling. 20113133033
chemical reduction system for the detection of phylloquinone (vitamin k1) and menaquinones (vitamin k2).both isocratic and gradient elution systems for fluorometric detection of k vitamins after post-column reduction with zinc metal to their hydroquinones are described. the reaction detection system for k vitamins (phylloquinone and menaquinones) in liquid chromatography is based on reduction of k vitamins to their corresponding hydroquinones with zinc metal in the presence of zinc ions. it was found that 95% of the injected quinones (k vitamins) could be reduced to their corresponding hydroquinon ...20113818857
[the contributions of iaşi to the study of acute diarrheal diseases (add)]. 20113187239
promoter selectivity of prokaryotic rna polymerases. 20113076288
promoter selectivity of prokaryotic rna polymerases. 20113076288
[intracranial aneurysms and subarachnoid hemorrhage in children and adolescents].42 cases concerning symptomatic intracranial circulation aneurysms and spontaneous sah have been observed by the authors during the period 1965-1984; 37 of them were treated from 1970 on. this group represents 2.6% in the number of patients treated for sah during the above mentioned period in the series of pavia and verona neurosurgery. in 7 cases angiography did not evidence any malformation responsible for the hemorrhage. these cases have been defined as "sine materia" sah. in 33 cases was doc ...20113725140
an immunohistological study of 66 ependymomas.sixty-six ependymomas were examined immunohistologically to determine their distribution of glial fibrillary acidic proteins, s-100 protein and vimentin. the neoplasms were subdivided into four groups: (1) ependymomas from the cauda equina, predominantly of the myxopapillary type; (2) benign ependymomas; (3) malignant ependymomas; and (4) ependymoblastomas. marked differences in antigen reactivity were observed between each group. the intensity of the reaction with the three antibodies was stron ...20113220468
c1q component of complement binds to fibrinogen and fibrin.the interaction of complement component c1q with fibrinogen and fibrin was studied by using a solid-phase direct binding assay. scatchard analysis of radioiodinated fibrinogen binding to c1q indicated at least two high-affinity binding constants (kd) calculated as 8.5 and 120 nm. in contrast, binding of radioiodinated fibrin to c1q showed only a single class of binding sites with a calculated kd of 600 nm. fibrinogen-c1q binding was shown to decrease as a function of increasing salt concentratio ...20113258162
c1q component of complement binds to fibrinogen and fibrin.the interaction of complement component c1q with fibrinogen and fibrin was studied by using a solid-phase direct binding assay. scatchard analysis of radioiodinated fibrinogen binding to c1q indicated at least two high-affinity binding constants (kd) calculated as 8.5 and 120 nm. in contrast, binding of radioiodinated fibrin to c1q showed only a single class of binding sites with a calculated kd of 600 nm. fibrinogen-c1q binding was shown to decrease as a function of increasing salt concentratio ...20113258162
a palatal package. 20113164187
structural studies of analgesics and their interactions. xii. structure and interactions of anti-inflammatory fenamates. a concerted crystallographic and theoretical conformational study.a theoretical conformational analysis of fenamates, which are n-arylated derivatives of anthranilic acid or 2-aminonicotinic acid with different substituents on the aryl (phenyl) group, is reported. the analysis of these analgesics, which are believed to act through the inhibition of prostaglandin biosynthesis, was carried out using semi-empirical potential functions. the results and available crystallographic observations have been critically examined in terms of their relevance to drug action. ...20113271554
minocycline-related hyperpigmentation. 20113158284
[the ph-dependent solubility of heavy metals from sewage sludge of different compositions].sludge suspensions of anaerobically digested sewage sludge, limed anaerobically digested sewage sludge, precipitation sludge of the tertiary waste water treatment and limed precipitation sludge were incubated for 8 days with continuous rotation at nine defined ph-values (ph 1, 3-10). after membrane filtration (0.45 micron) solution concentrations of zn, cd, cu, pb and cr were determined by atomic absorption spectroscopy. results show that solubilities of cd, zn and cu depend not only on ph-value ...20113147555
recipient selection for heart-lung transplantation.cardiac transplantation has emerged as a standard mode of clinical therapy for end-stage heart failure, while heart-lung transplantation is still an experimental rather than a standard mode of clinical therapy for end-stage heart and lung disease. since clinical application of heart-lung transplantation began in march 1981, there has been continual improvement in donor care, surgery, post-operative management, and the diagnosis and treatment of lung and heart rejection. according to our 6-year c ...20113147509
nutrition and diabetes: a review of current recommendations (continuing education credit). 20113203614
value of cerebrospinal fluid analysis in the differential diagnosis of meningitis: a study in 710 patients with suspected central nervous system infection.a prospective study to determine the value of cerebrospinal fluid analysis in the differential diagnosis of meningitis was performed in 710 consecutively observed patients, both children and adults, who underwent lumbar puncture due to suspected central nervous system infection. diagnoses included acute or presumed bacterial meningitis (n = 79), acute or presumed viral meningoencephalitis (n = 218), acute unclassified meningitis (n = 6), other infections of the central nervous system (n = 37), n ...20113137038
corticosteroids and cromolyn sodium as modulators of airway inflammation.heightened airway reactivity is a cardinal feature of asthma and correlates with many clinical features of the illness, such as the acute response to bronchodilator drugs, the magnitude of diurnal fluctuations in lung function, and the amount of therapy required to control symptoms. data have accumulated indicating that a reduction in airway reactivity can decrease asthma morbidity, and many advocate treating asthmatic patients prophylactically to prevent acute exacerbations from developing, rat ...20113133163
current trends in enteral feeding. 20113133160
alcoholism and skin disease.one hundred and one patients who met criteria for alcoholism were evaluated for dermatologic signs. there were 98 men and 3 women, with an average age of 40.85 years; 40 were white and 61 black. significant findings were no skin disease in 19, acne in 27, folliculitis in 8, seborrheic dermatitis in 12, tinea pedis in 32, and xerosis in 7. only two patients had rosacea, which is contrary to previously held beliefs about the drinker's nose.20113160677
pemphigoid-like bullous eruption related to ibuprofen.we report two patients who had a bullous eruption limited to the lower extremities when first seen by us. clinically the eruption resembled limited bullous pemphigoid. in both patients the onset of the eruption was associated with ibuprofen therapy, and lesions promptly resolved after discontinuing the ibuprofen. this type of presentation has not been reported previously as an adverse effect of ibuprofen. bullous reactions to nonsteroidal anti-inflammatory agents are briefly reviewed.20113042819
bimaxillary proclination in patients of afro-caribbean origin.the facial morphology of the afro-caribbean negro is reviewed and the aims of treatment for bimaxillary proclination and its subsequent stability are discussed. treatment approaches to various clinical situations are described, together with their known limitations.20113048380
limitations in the use of 14c-glycocholate breath and stool bile acid determinations in patients with chronic diarrhea.analysis of a modified 14c-glycocholate breath test on 165 consecutive in-patients being investigated for chronic diarrhea showed that the measurement of 14co2 between 3 and 6 h after oral dosing of 5 microci of 14c-glycocholic acid was of only limited use to distinguish between patients with crohn's disease (cd), idiopathic bile salt wastage (ibw), or ileal resection (ir) from those with the irritable bowel syndrome (ibs). continuing 14co2 collections for up to 24 h was of little more help in e ...20113090133
[histological confirmation of monostotic paget's disease in the sacrum by ct-guided bone puncture biopsy]. 20113024265
captopril--a new approach for treatment of male subfertility? 20113067628
[clinical pharmacology of converting enzyme inhibitors]. 20113375761
definition of events associated with drugs: regulatory perspectives.drug regulations in the united states require that all clinical events reported associated with a marketed drug be collected by the manufacturer and provided to the regulatory agency. in the clinical setting, many factors determine (a) the likelihood of an event being detected, (b) the attribution of the event to the drug, and (c) the actual spontaneous reporting of the drug event association to the manufacturer, regulator or to the literature. in formal postmarketing trials to collect informati ...20113204615
mathematical modeling of vibrio vulnificus infection in korea and the influence of global warming.to investigate the possible link between vibrio vulnificus population size in seawater and water temperature.201124159451
genotypic characterization of vibrio vulnificus clinical isolates in korea.vibrio vunificus is known to cause septicemia and severe wound infections in patients with chronic liver diseases or an immuno-compromised condition. we carried out the molecular characterization of v. vulnificus isolates from human vibrio septicemia cases based on pulsed-field gel electrophoresis (pfge) using noti and sfii.201124159444
expression of high mobility group protein b1 in the lungs of rats with sepsis.vibrio vulnificus inside the body could activate the nf-κb signaling pathway and initiate the inflammatory cascade. the lung is one of the earliest organs affected by sepsis associated with acute lung injury. high mobility group protein b1 (hmgb1) is an important late-acting pro-inflammatory cytokine involving in the pathophysiology of sepsis. it is also involved in the injury process in the lung, liver and intestine. there has been no report on the involvement of hmgb1 in vibrio vulnificus seps ...201125215028
vibrio vulnificus genome suggests two distinct ecotypes.the genus vibrio contains several of the most important pathogens known. one member of this group, vibrio vulnificus, is an estuarine bacterium which is the causative agent of both food-borne disease and wound infection. vibrio vulnificus is ubiquitous in estuarine waters and occurs in molluscan shellfish in high numbers. however, the incidence of disease is relatively low and it has been suggested that not all strains of v. vulnificus are equally virulent. we have previously shown that there is ...201023766007
uptake and depuration of the c- and e-genotypes of vibrio vulnificus by the eastern oyster (crassostrea virginica).the human pathogen vibrio vulnificus is a gram-negative estuarine bacterium that infect via wounds and ingestion, and is the leading cause of seafood-borne death in the united states. vibrio vulnificus is part of the naturally occurring flora of both estuaries and estuarine mollusks (especially oysters). vibrio vulnificus is divided into two genotypes, including a clinically associated c-type, and an environmentally associated e-type that is more rarely involved in septicemia. these two genotype ...201023766004
rapid in situ detection of virulent vibrio vulnificus strains in raw oyster matrices using real-time pcr.vibrio vulnificus is a gram-negative bacterial pathogen responsible for the vast majority of bacterially mediated fatalities from the consumption of raw or undercooked seafood in the usa. vibrio vulnificus-associated septicaemia can occur rapidly (< 24 h); however, methods for the isolation and confirmation of v. vulnificus from seafood samples typically require several days. a real-time pcr assay was developed for v. vulnificus biotype 1 that provides a rapid means of identifying a gene fragmen ...201023766001
necrotising fasciitis with vibrio vulnificus: a limb threatening dermatologic complication following exposure to marine life.vibrio vulnificus is a rare cause of necrotising fasciitis. the organism can be found in warm, shallow coastal waters, as well as on shellfish, such as crab, and also filter-feeding molluscs, such as oysters, clams, and scallops. in the usa, it is the leading cause of shellfish related deaths. in individuals with major underlying illnesses, such as liver disease, diabetes mellitus, malignancy, alcoholism, haemochromatosis or chronic renal disease, the organism can lead to a fulminant course with ...201022736735
evidence of antibacterial activities in peptide fractions originating from snow crab (chionoecetes opilio) by-products.antibacterial peptide fractions generated via proteolytic processing of snow crab by-products exhibited activity against gram-negative and gram-positive bacteria. among the bacterial strains tested, peptide fractions demonstrated inhibitory activity against the gram-negative bacteria such as aeromonas caviae, aeromonas hydrophila, campylobacter jejuni, listonella anguillarum, morganella morganii, shewanella putrefasciens, vibrio parahaemolyticus and vibrio vulnificus and against a few gram-posit ...201026781242
environmental occurrence and clinical impact of vibrio vulnificus and vibrio parahaemolyticus: a european perspective.vibrio vulnificus and vibrio parahaemolyticus are ubiquitous gram-negative bacterial pathogens found naturally in marine and estuarine waters, and are a leading cause of seafood-associated bacterial illness. these pathogens are commonly reported in the usa and in many asian countries, including china, japan and taiwan; however, there is growing concern that v. vulnificus and v. parahaemolyticus may represent an important and increasing clinical problem in europe. several factors underlie the nee ...201023765993
extragonadal retroperitoneal germ cell tumors without apparent testicular involvement. a search for the source.extratesticular germ cell neoplasms without apparent testicular primary tumors are rare. the origin of these neoplasms has been debated in the literature for decades. with the advent of effective chemotherapy for extratesticular germ cell neoplasms, the origin of these tumors becomes more than academic. we report on 3 cases of retroperitoneal germ cell neoplasms with microscopic intratesticular primary tumors. all patients with extragonadal germinal cell tumors of the testes should undergo thoro ...20103012846
extragonadal retroperitoneal germ cell tumors without apparent testicular involvement. a search for the source.extratesticular germ cell neoplasms without apparent testicular primary tumors are rare. the origin of these neoplasms has been debated in the literature for decades. with the advent of effective chemotherapy for extratesticular germ cell neoplasms, the origin of these tumors becomes more than academic. we report on 3 cases of retroperitoneal germ cell neoplasms with microscopic intratesticular primary tumors. all patients with extragonadal germinal cell tumors of the testes should undergo thoro ...20103012846
the adenosine triphosphate-pyrophosphate isotopic exchange reaction: a tool for determination of tryptophan.quantitative determination of tryptophan at the picomole level is described, using the atp-[32p]ppi isotopic exchange reaction catalyzed by tryptophanyl-trna synthetase. sensitivity limits of 500 fmol were obtained. the presence of other amino acids at a 1000-fold excess over tryptophan did not interfere significantly with the quantitative determination of tryptophan. the specificity of the reaction was checked using five tryptophan analogs. these analogs did not prevent the determination of try ...20103014918
[kinin aminopeptidase in lung tissue and activity of kininase ii in the serum of patients with silicosis]. 20103020528
[kinin aminopeptidase in lung tissue and activity of kininase ii in the serum of patients with silicosis]. 20103020528
additional eye findings in a girl with the velo-cardio-facial syndrome. 20103089013
chemotaxis in eukaryotic cells: a focus on leukocytes and dictyostelium. 20102848555
thiol peroxyl radical formation from the reaction of cysteine thiyl radical with molecular oxygen: an esr investigation.using electron spin resonance (esr) spectroscopy, we have identified the cysteine thiol peroxyl radical (cyssoo.) at low temperatures in two aqueous glasses. this radical shows a typical peroxyl radical esr spectrum, but unlike carbon-based peroxyl radicals has a violet color (lambda max = 540 nm) and forms a new radical showing a singlet esr spectrum when photobleached with visible light. the cysteine peroxyl radical reacts to form the cysteine sulfinyl radical (cysso.) in the glass which allow ...20102843184
evaluation of guar biscuits for use in the management of diabetes: tests of physiological effects and palatability in non-diabetic volunteers.a guar-shortbread biscuit has been successfully developed and tested for possible use in the dietary management of diabetes. a dose-response study was undertaken to estimate the amount of guar gum needed in the biscuit recipe to reduce postprandial glycaemia and insulinaemia. a control biscuit and three types of guar biscuit corresponding to a low, medium and high dose of guar (2.9, 6.0 and 9.1 g of guar respectively) were given to 8 non-diabetic subjects, and blood glucose and plasma insulin le ...20102840279
the history of the use of vacuum extraction. 20103047531
isolated duodenal tamponade for treatment of bleeding duodenal ulcer. 20102895833
characterization of two types of histone h2b genes from macronuclei of tetrahymena thermophila.two histone h2b gene clones were isolated from macronuclei of tetrahymena thermophila. nucleotide sequences of the two clones were highly homologous within the coding region but not in the noncoding region. comparison of the deduced amino acid sequences between the two clones showed three differences in a total of 121 amino acids. each of the two clones contained a taa triplet within the coding region, which appeared to code for a glutamine residue. to demonstrate the existence of histone mrna c ...20103039463
use of locally injected anti-t monoclonal antibodies in the treatment of acute corneal graft rejection. 20103108097
clinical and radiologic features of lacunar versus nonlacunar minor stroke.we determined the angiographic presence of extracerebral and intracerebral arterial disease in 122 patients with minor stroke within the carotid territory; we excluded patients with a recognized cardiac source of emboli. based on clinical features and computed tomographic findings, patients were classified as having lacunar infarcts (n = 61), nonlacunar infarcts (n = 53), and infarcts of indeterminate type (n = 8). severe carotid bifurcation disease (greater than or equal to 50% stenosis or occl ...20102911836
[a multi-factorial approach in the vital prognosis of spontaneous intracerebral hematoma].the prognostic assessment of a patient with intra-cerebral hemorrhage (ih) requires simultaneous appraisal of several parameters. we have attempted this with a multivariate method: discriminant analysis. we studied retrospectively 142 patients with non-operated ih, not due to vascular malformation, distributed two months after the initial event in two groups: 92 living patients and 50 dead. discriminant analysis of 21 parameters from the initial examination and ct scan, selected five factors whi ...20103047834
reflex sympathetic dystrophy following nail biopsy.reflex sympathetic dystrophy following a nail unit biopsy in a patient with long-standing, mycologically negative onychomycosis is reported. the significance of this complication is discussed, and the literature on the condition itself is reviewed. it is suggested that although adverse effects occur as a result of nail biopsy, they are infrequent and therefore should not dissuade the clinician from performing the procedure. biopsy is necessary in order to establish a more accurate diagnosis of n ...20102950143
hodgkin's disease in the spleen. a morphological study of 140 biopsy cases.140 spleens involved by untreated hodgkin's disease were studied utilizing conventional histological methods. regardless of the subtype of hodgkin's disease, infiltrates of neoplastic cells were present either in the periarteriolar lymphoid sheath, the marginal zone or in both locations. initially, infiltrates were confined to the splenic white pulp, later larger nodular foci of hodgkin's disease developed by coalescence of several infiltrates. neoplastic cells in hodgkin's disease may reach the ...20103114946
diabetogenic action of calcitonin in acute experiment in healthy humans. 20102894137
aspartylglycosaminuria (agu). further aspects on its clinical picture, mode of inheritance and epidemiology based on a series of 57 patients. 20104356121
adenosine receptors mediate pigment dispersion in leucophores of the medaka, oryzias latipes.using the medaka, oryzias latipes (orange-red variety), the mechanisms of action on leucophores of adenosine and adenine nucleotides, including cyclic amp, were studied. all these substances were found to be very effective in dispersing leucosomes. their pigment-dispersing action was antagonized by methylxanthines. these substances did not aggregate leucosomes. it was concluded that leucophores possess specific binding sites for adenosine, i.e. adenosine receptors, on the cell membrane, which me ...20102877798
childhood cancer in siblings.the medical records of 973 previously untreated patients diagnosed between january 1960 and december 31, 1978 with childhood cancer were reviewed. siblings in 13 families were diagnosed with cancer 9/12 to 15 years after the diagnosis of cancer in the index sibling. previously unreported association of acute lymphoblastic leukemia with hodgkin's disease, neuroblastoma with malignant hemangiopericytoma, non-hodgkin's lymphoma with malignant melanoma, wilms' tumor with non-hodgkin's lymphoma, hodg ...20103153235
nh2-terminal amino acid sequence analysis of qa-2 alloantigens. 20102925232
[surgery in the treatment of patients with small cell lung cancer].the data on surgical and combined treatment of 52 cases of small cell lung cancer are presented and the end results are evaluated. the findings on survival time make the case for surgery as a component of combined treatment of tumor. the best results were obtained in cases of stage i and ii tumor, absence of metastases into intrathoracic lymph nodes, tumor invasion limited to bronchopulmonary lymph nodes or the root of the lung, intermediate cell pattern of small cell lung cancer and surgery fol ...20102998088
[unusual computed tomographic findings following shunting of hydrocephalus internus permagnus]. 20103008264
treatment of mooren's ulcer with cyclosporin a: report of three cases.three patients with severe, bilateral, progressive mooren's ulcers, unresponsive to medical and surgical therapy, were treated with cyclosporin a. all three responded rapidly to the drug and there has been no recurrence of the mooren's ulcers since (average follow-up 14 months). peripheral blood t lymphocyte subsets were estimated prior to and during treatment. no significant abnormalities were found initially. suppressor cells increased on treatment, and a corresponding drop of the helper/suppr ...20102949775
cyclophosphamide in chronic progressive multiple sclerosis. 20103037447
cyclophosphamide in chronic progressive multiple sclerosis. 20103037447
congenital adrenal hyperplasia. 20102887945
anti-idiotypic antibodies: a new generation of vaccines against infectious agents.anti-idiotypic antibodies have been suggested recently as candidates for potential vaccines against numerous infectious organisms. these antibody-based vaccines might represent a new generation of vaccines for inducing protective immunity in susceptible hosts.20103153167
directives, methods and suggestions for anti-ulcer drug therapy. 20102876535
[neurosis or psychosis: a formal differentiation of practical interest]. 20102797301
the cellular immune response in thermal injured patients. 20103008532
regeneration and repair of periodontal tissues. 20102955107
[how to prevent the tumor lysis syndrome]. 20102935797
the craniofacial morphology in persons with maxillonasal dysplasia (binder syndrome). a longitudinal cephalometric study of orthodontically treated children.the aim of this investigation was to study the influence of orthodontic treatment on facial growth in subjects with maxillonasal dysplasia. the subjects were followed longitudinally from early childhood until growth was completed or almost completed. fifteen patients, 9 boys and 6 girls, were orthodontically treated by conventional methods. they were compared with (1) another longitudinal group consisting of 13 orthodontically untreated children, 7 boys and 6 girls with the same syndrome, and (2 ...20102916471
[an experience with combined procurement of the liver and kidneys for transplantation by a british team (cambridge)]. 20102935806
[arterial hypertension in the aged]. 20102876472
inhibition of nucleic acid synthesis in p-388 lymphocytic leukemia cells in culture by sesquiterpene lactones.helenalin and bis (helenalinyl) malonate, sesquiterpene lactones, were shown to be cytotoxic against the growth of p-388 lymphocytic leukemia cells in culture. dna and protein synthesis were reduced by these agents preferentially, with rna synthesis being affected only marginally. this study focused on the identification of the enzyme target(s) responsible for the inhibition of dna synthesis by the sesquiterpene lactones. purine synthesis was strongly inhibited at the imp dehydrogenase step. sup ...20102895992
physical exercise--an important factor for health. a position statement from the international federation of sports medicine. 20102814432
activation of a cytosolic serine protein kinase by epidermal growth factor.exposure of a-431 cells to epidermal growth factor (egf) results in a rapid enhancement (approximately 10-fold) of cytosolic serine protein kinase activity. the increase in serine kinase activity may be detected using a number of peptide and protein substrates. enhancement of kinase activity occurs within 1 min of exposure of the cells to egf and reaches a maximum in 5 min. similar results were obtained with a variety of cell lines. we have partially purified the egf-activated kinase from a-431 ...20102974035
the need for a more robust ozone air quality standard.the present national ambient air quality standard for ozone has many statistical problems, including use of extreme values which have inherent large fluctuations, a compliance test that can gradually lower the target of the design value below the standard level, and inconsistencies between the number-of-exceedances criterion and the design value. the above problems can be avoided or minimized by using a more robust statistic, such as the 95th percentile, and applying a statistical compliance tes ...20102795112
virulence characteristics of sucrose-fermenting vibrio vulnificus strains.we identified 6 sucrose-fermenting vibrio vulnificus strains and examined their virulence characteristics. they were all encapsulated, motile, capable of producing toxins and utilizing transferrin-bound iron, cytotoxic to cultured cells, and virulent enough to kill mice. they could be definitely identified only by genetic identification methods such as pcr, and not by conventional culture-based identification methods such as api 20e (biomérieux, france). these results indicate that it is essenti ...201020890083
evidence for the horizontal transfer of an unusual capsular polysaccharide biosynthesis locus in marine bacteria.the most intensely studied of the vibrio vulnificus virulence factors is the capsular polysaccharide (cps). all virulent strains produce copious amounts of cps. acapsular strains are avirulent. the structure of the cps from the clinical isolate atcc 27562 is unusual. it is serine modified and contains, surprisingly, n-acetylmuramic acid. we identified the complete 25-kb cps biosynthesis locus from atcc 27562. it contained 21 open reading frames and was allelic to o-antigen biosynthesis loci. two ...201020921143
macrophage migration inhibitory factor regulates interleukin-6 production by facilitating nuclear factor-kappa b activation during vibrio vulnificus infection.patients infected with vibrio vulnificus (v. vulnificus) show severe inflammatory responses characterised by the upregulation of proinflammatory cytokines. macrophage migration inhibitory factor (mif), an upstream proinflammatory regulator, increases the inflammation caused by sepsis. whether mif regulates responses to v. vulnificus infection and the actual mechanism by which v. vulnificus initiates these mif-modulated proinflammatory cytokines remain unclear.201020939898
[correlations between climate change-related infectious diseases and meteorological factors in korea].infectious diseases are known to be affected by climate change. we investigated if the infectious diseases were related to meteorological factors in korea.201020959714
a mammalian insulysin homolog is regulated by enzyme iia(glc) of the glucose transport system in vibrio vulnificus.vibrio vulnificus is an opportunistic human pathogen that causes severe infections in susceptible individuals. while the components of the escherichia coli phosphoenolpyruvate: sugar phosphotransferase system (pts) have been shown to regulate numerous targets, little such information is available for the v. vulnificus pts. here we show that enzyme iia(glc) of the pts regulates the peptidase activity of a mammalian insulysin homolog in v. vulnificus. while interaction of iia(glc) with the insulys ...201020971110
interactive effects of cadmium and hypoxia on metabolic responses and bacterial loads of eastern oysters crassostrea virginica gmelin.pollution by toxic metals including cadmium (cd) and hypoxia are important stressors in estuaries and coastal waters which may interactively affect sessile benthic organisms, such as oysters. we studied metabolic responses to prolonged hypoxic acclimation (2 weeks at 5% o2) in control and cd-exposed (30 d at 50 μg l(-1) cd) oysters crassostrea virginica, and analyzed the effects of these stressors on abundance of vibrio spp. in oysters. hypoxia-acclimated oysters retained normal standard metabol ...201020971492
sepsis and fulminant multi-organ failure associated with vibrio vulnificus infection. 201021038545
genetic analysis of the capsule polysaccharide (k antigen) and exopolysaccharide genes in pandemic vibrio parahaemolyticus o3:k6.pandemic vibrio parahaemolyticus has undergone rapid changes in both k- and o-antigens, making detection of outbreaks more difficult. in order to understand these rapid changes, the genetic regions encoding these antigens must be examined. in vibrio cholerae and vibrio vulnificus, both o-antigen and capsular polysaccharides are encoded in a single region on the large chromosome; a similar arrangement in pandemic v. parahaemolyticus would help explain the rapid serotype changes. however, previous ...201021044320
studies on a vibrio vulnificus functional ortholog of escherichia coli rnase e imply a conserved function of rnase e-like enzymes in bacteria.rnase e (rne) plays a key role in the processing and degradation of rna in escherichia coli. in the genome of vibrio vulnificus, one open reading frame potentially encodes a protein homologous to e. coli rnase e, designated rnase ev, which n-terminal (1-500 amino acids) has 86.4% amino acid identity to the n-terminal catalytic part of rnase e (n-rne). here, we report that both the full-length and the n-terminal part of rnase ev (n-rnev) functionally complement e. coli rnase e and their expressio ...201021046401
calcium promotes exopolysaccharide phase variation and biofilm formation of the resulting phase variants in the human pathogen vibrio vulnificus.vibrio vulnificus is a gram-negative bacterium found in estuaries and coastal waters and is associated with human disease caused by ingestion of raw shellfish. pathogenesis is directly related to the presence of capsular polysaccharide (cps). encapsulated virulent strains exhibit an opaque colony phenotype, while unencapsulated attenuated strains appear translucent. a third colony type, rugose, is caused by expression of rugose extracellular polysaccharide (reps) and forms robust biofilms. vibri ...201021059165
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