Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| marine indole alkaloids. | marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. the newly isolated indole alkaloids of marine origin since the last comprehensive review in 200 ... | 2015 | 26287214 |
| an unusual cause of necrosis and nasal septum perforation after septoplasty: enterobacter cloacae. | a 20-year-old man with nasal obstruction underwent septoplasty due to nasal septal deviation. nasal packs were inserted at the end of surgery and removed 48 hours after surgery. twenty-four hours after removal of nasal packs, there was necrosis in both sides of septal mucosa and in bilateral inferior turbinates. nasal swab culture was performed from both nasal cavities. enterobacter cloacae was isolated from samples. two weeks after surgery, nasal septum perforation was unavoidable. to our knowl ... | 2015 | 27257495 |
| rectal carriage of extended-spectrum-beta-lactamase-producing enterobacteriaceae in hospitalized patients: selective preenrichment increases yield of screening. | this study evaluated the added value of selective preenrichment for the detection of rectal carriage of extended-spectrum-beta-lactamase-producing enterobacteriaceae (esbl-e). esbl-e rectal carriage was identified in 4.8% of hospitalized patients, and 25.9% of esbl-e rectal carriers were identified with selective preenrichment only. | 2015 | 25994164 |
| bla ctx-m-i group extended spectrum beta lactamase-producing salmonella typhi from hospitalized patients in lagos, nigeria. | the global spread of bla ctx-m-i extended-spectrum beta-lactamase (esbl)-producing salmonella spp. remains a major threat to treatment and control. evidence of emergence and spread of this marker are lacking in nigeria. this study investigated bla ctx-m-i esbl production among salmonella isolates from hospitalized patients. | 2015 | 25999745 |
| production and assay of cellulolytic enzyme activity of enterobacter cloacae wpl 214 isolated from bovine rumen fluid waste of surabaya abbatoir, indonesia. | this study aims to produce and assay cellulolytic enzyme activity (endo-(1,4)-β-d-glucanase, exo-(1,4)-β-d-glucanase, and β-glucosidase, at optimum temperature and optimum ph) of enterobacter cloacae wpl 214 isolated from bovine rumen fluid waste of surabaya abbatoir, indonesia. | 2015 | 27047099 |
| treatment experience of severe abdominal infection after orthotopic liver transplantation. | this study aims to investigate the causes and treatment experience of severe abdominal infection after orthotopic liver transplantation. clinical data were retrospectively analysed in perioperative severe abdominal infection of 186 orthotopic liver transplantation cases from march 2004 to november 2011. among the 186 patients, 16 cases had severe abdominal infection: five cases had bile duct anastomotic leakage-inducing massive hydrops and infection under liver interstice, 10 cases had extensive ... | 2015 | 26426173 |
| treatment experience of severe abdominal infection after orthotopic liver transplantation. | this study aims to investigate the causes and treatment experience of severe abdominal infection after orthotopic liver transplantation. clinical data were retrospectively analysed in perioperative severe abdominal infection of 186 orthotopic liver transplantation cases from march 2004 to november 2011. among the 186 patients, 16 cases had severe abdominal infection: five cases had bile duct anastomotic leakage-inducing massive hydrops and infection under liver interstice, 10 cases had extensive ... | 2015 | 26426173 |
| isolation and screening of bacteria for their diazotrophic potential and their influence on growth promotion of maize seedlings in greenhouses. | poor soil fertility is one of the major constraints for crop production. nitrogen is the most limiting nutrient for increasing crop productivity. therefore, there is a need to identify diazotrophic inoculants as an alternative or supplement to n-fertilizers for sustainable agriculture. in the current study, a number of free-living diazotrophic bacteria were isolated from soils collected from maize rhizosphere and from leaves and roots of maize within the kwazulu-natal province, republic of south ... | 2015 | 26779245 |
| isolation and screening of bacteria for their diazotrophic potential and their influence on growth promotion of maize seedlings in greenhouses. | poor soil fertility is one of the major constraints for crop production. nitrogen is the most limiting nutrient for increasing crop productivity. therefore, there is a need to identify diazotrophic inoculants as an alternative or supplement to n-fertilizers for sustainable agriculture. in the current study, a number of free-living diazotrophic bacteria were isolated from soils collected from maize rhizosphere and from leaves and roots of maize within the kwazulu-natal province, republic of south ... | 2015 | 26779245 |
| characteristics of korean patients with antithyroid drug-induced agranulocytosis: a multicenter study in korea. | antithyroid drugs (atds) can lead to the development of agranulocytosis, which is the most serious adverse effect. characteristics of atd-induced agranulocytosis (aia) have seldom been reported due to the rarity. in this study, we characterized the clinical features for aia in korean patients. | 2015 | 26394729 |
| genomic characteristics of ndm-producing enterobacteriaceae isolates in australia and their blandm genetic contexts. | blandm has been reported in different enterobacteriaceae species and on numerous plasmid replicon types (inc). plasmid replicon typing, in combination with genomic characteristics of the bacterial host (e.g., sequence typing), is used to infer the spread of antimicrobial resistance determinants between genetically unrelated bacterial hosts. the genetic context of blandm is heterogeneous. in this study, we genomically characterized 12 ndm-producing enterobacteriaceae isolated in australia between ... | 2015 | 26482302 |
| genomic characteristics of ndm-producing enterobacteriaceae isolates in australia and their blandm genetic contexts. | blandm has been reported in different enterobacteriaceae species and on numerous plasmid replicon types (inc). plasmid replicon typing, in combination with genomic characteristics of the bacterial host (e.g., sequence typing), is used to infer the spread of antimicrobial resistance determinants between genetically unrelated bacterial hosts. the genetic context of blandm is heterogeneous. in this study, we genomically characterized 12 ndm-producing enterobacteriaceae isolated in australia between ... | 2015 | 26482302 |
| role of non-active-site residue trp-93 in the function and stability of new delhi metallo-β-lactamase 1. | new delhi metallo-β-lactamase-1 (ndm-1) is expressed by various members of enterobacteriaceae as a defense mechanism to hydrolyze β-lactam antibiotics. despite various studies showing the significance of active-site residues in the catalytic mechanism, there is a paucity of reports addressing the role of non-active-site residues in the structure and function of ndm-1. in this study, we investigated the significance of non-active-site residue trp-93 in the structure and function of ndm-1. we clon ... | 2015 | 26525789 |
| role of non-active-site residue trp-93 in the function and stability of new delhi metallo-β-lactamase 1. | new delhi metallo-β-lactamase-1 (ndm-1) is expressed by various members of enterobacteriaceae as a defense mechanism to hydrolyze β-lactam antibiotics. despite various studies showing the significance of active-site residues in the catalytic mechanism, there is a paucity of reports addressing the role of non-active-site residues in the structure and function of ndm-1. in this study, we investigated the significance of non-active-site residue trp-93 in the structure and function of ndm-1. we clon ... | 2015 | 26525789 |
| population pharmacokinetics and pharmacodynamics of extended-infusion piperacillin and tazobactam in critically ill children. | the study objective was to evaluate the population pharmacokinetics and pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in an intensive care unit. seventy-two serum samples were collected at steady state from 12 patients who received piperacillin-tazobactam at 100/12.5 mg/kg of body weight every 8 h infused over 4 h. population pharmacokinetic analyses were performed using nonmem, and monte carlo simulations were performed to estimate the piperacillin pharm ... | 2015 | 26552978 |
| population pharmacokinetics and pharmacodynamics of extended-infusion piperacillin and tazobactam in critically ill children. | the study objective was to evaluate the population pharmacokinetics and pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in an intensive care unit. seventy-two serum samples were collected at steady state from 12 patients who received piperacillin-tazobactam at 100/12.5 mg/kg of body weight every 8 h infused over 4 h. population pharmacokinetic analyses were performed using nonmem, and monte carlo simulations were performed to estimate the piperacillin pharm ... | 2015 | 26552978 |
| infections in patients undergoing craniotomy: risk factors associated with post-craniotomy meningitis. | object the authors performed a prospective study to define the prevalence and microbiological characteristics of infections in patients undergoing craniotomy and to clarify the risk factors for post-craniotomy meningitis. methods patients older than 18 years who underwent nonstereotactic craniotomies between january 2006 and december 2008 were included. demographic, clinical, laboratory, and microbiological data were systemically recorded. patient characteristics, craniotomy type, and pre- and p ... | 2015 | 25343179 |
| a two-year surveillance in five colombian tertiary care hospitals reveals high frequency of non-cg258 clones of carbapenem-resistant klebsiella pneumoniae with distinct clinical characteristics. | the global spread of carbapenem-resistant klebsiella pneumoniae (cr-kp) has been largely associated with sequence type 258 (st258) and its related variants (clonal group 258 [cg258]). here we describe the molecular epidemiology of cr-kp from five tertiary care hospitals in medellín, the second largest city in colombia. all cr-kp-infected patients admitted from june 2012 to june 2014 were included (n = 193). patients' clinical information was obtained from medical records. carbapenemase kpc, vim, ... | 2015 | 26503660 |
| a two-year surveillance in five colombian tertiary care hospitals reveals high frequency of non-cg258 clones of carbapenem-resistant klebsiella pneumoniae with distinct clinical characteristics. | the global spread of carbapenem-resistant klebsiella pneumoniae (cr-kp) has been largely associated with sequence type 258 (st258) and its related variants (clonal group 258 [cg258]). here we describe the molecular epidemiology of cr-kp from five tertiary care hospitals in medellín, the second largest city in colombia. all cr-kp-infected patients admitted from june 2012 to june 2014 were included (n = 193). patients' clinical information was obtained from medical records. carbapenemase kpc, vim, ... | 2015 | 26503660 |
| evaluation of a genus- and group-specific rapid pcr assay panel on synovial fluid for diagnosis of prosthetic knee infection. | we evaluated a genus- and group-specific pcr assay panel using 284 prosthetic knee synovial fluid samples collected from patients presenting to our institution with implant failure. using the musculoskeletal infection society diagnostic criteria, 88 and 196 samples were classified as showing prosthetic joint infection (pji) and aseptic failure (af), respectively. sensitivities of the synovial fluid pcr panel and culture were 55.6% and 76.1% (p ≤ 0.001), respectively, and specificities were 91.8% ... | 2015 | 26537446 |
| evaluation of a genus- and group-specific rapid pcr assay panel on synovial fluid for diagnosis of prosthetic knee infection. | we evaluated a genus- and group-specific pcr assay panel using 284 prosthetic knee synovial fluid samples collected from patients presenting to our institution with implant failure. using the musculoskeletal infection society diagnostic criteria, 88 and 196 samples were classified as showing prosthetic joint infection (pji) and aseptic failure (af), respectively. sensitivities of the synovial fluid pcr panel and culture were 55.6% and 76.1% (p ≤ 0.001), respectively, and specificities were 91.8% ... | 2015 | 26537446 |
| antibacterial activities of the methanol extracts and compounds from erythrina sigmoidea against gram-negative multi-drug resistant phenotypes. | in the present study, the methanol extracts from the leaves, as well as compounds namely sigmoidin i (1), atalantoflavone (2), bidwillon a (3), neocyclomorusin (4), 6α-hydroxyphaseollidin (5) and neobavaisoflavone (6) (from the bark extract) were tested for their activities against a panel of gram-negative bacteria including multi-drug resistant (mdr) phenotypes. | 2015 | 26715029 |
| antibacterial activity of nineteen selected natural products against multi-drug resistant gram-negative phenotypes. | the present study was designed to assess the antimicrobial activity of 19 natural products belonging to terpenoids, alkaloids, thiophenes and phenolics against a panel of 14 gram-negative multidrug-resistant (mdr) bacteria. the results demonstrated that amongst the studied compounds, alkaloids and terpenoids were less active contrary to flavonoids: neocyclomorusin (3) and candidone (6) and isoflavonoids: neobavaisoflavone (8) and daidzein (12). thiophene, 2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut ... | 2015 | 26753111 |
| spontaneous clearance of hepatitis c virus after liver transplantation: a report of four cases. | end-stage liver disease associated with hepatitis c virus (hcv) infection is the leading indication for liver transplantation. hepatitis c virus infection recurrence in the graft is common under immunosuppression, leading to an accelerated rate of graft failure. we report the clinical features of four of our patients: three patients presenting with spontaneous hepatitis c virus clearance after liver transplantation and one presenting with transient disappearance of hepatitis c virus postoperativ ... | 2015 | 26943448 |
| phlegmonous gastritis secondary to superior mesenteric artery syndrome. | we herein report a case of phlegmonous gastritis secondary to superior mesenteric artery syndrome. an 80-year-old woman visited the hospital emergency department with the chief complaints of epigastric pain and vomiting. she was hospitalized urgently following the diagnosis of superior mesenteric artery syndrome based on abdominal computed tomography findings. conservative therapy was not effective, and phlegmonous gastritis was diagnosed based on the findings of upper gastrointestinal endoscopy ... | 2015 | 27489695 |
| examining the clinical effectiveness of non-carbapenem β-lactams for the treatment of extended-spectrum β-lactamase-producing enterobacteriaceae. | treatment options for extended-spectrum β-lactamase-producing enterobacteriaceae are limited. piperacillin-tazobactam and cefepime represent potential alternative treatment options; however, large prospective studies are lacking. this review evaluates the current literature regarding use of piperacillin-tazobactam and cefepime for the treatment of extended-spectrum β-lactamase-producing enterobacteriaceae. antimicrobial stewardship programs can play a key role in guiding the best practices for t ... | 2015 | 27025645 |
| the microbiome of diabetic foot osteomyelitis. | the purpose of this investigation was to evaluate the diversity of bacteria in diabetic foot osteomyelitis using a 16s rrna sequencing approach and to compare the results with conventional culture techniques. in this prospective observational study, we obtained 34 bone samples from patients admitted to our hospital with a moderate-severe diabetic foot infection. we analysed the distribution of the 16s rrna gene sequences in the bone samples, using an illumina miseq personal sequencer. we compare ... | 2015 | 26670675 |
| the microbiome of diabetic foot osteomyelitis. | the purpose of this investigation was to evaluate the diversity of bacteria in diabetic foot osteomyelitis using a 16s rrna sequencing approach and to compare the results with conventional culture techniques. in this prospective observational study, we obtained 34 bone samples from patients admitted to our hospital with a moderate-severe diabetic foot infection. we analysed the distribution of the 16s rrna gene sequences in the bone samples, using an illumina miseq personal sequencer. we compare ... | 2015 | 26670675 |
| surgical site infections in a longitudinal cohort of neonatal intensive care unit patients. | to estimate the incidence and identify risk factors for surgical site infections (ssis) among infants in the neonatal intensive care unit (nicu). | 2015 | 26658124 |
| surgical site infections in a longitudinal cohort of neonatal intensive care unit patients. | to estimate the incidence and identify risk factors for surgical site infections (ssis) among infants in the neonatal intensive care unit (nicu). | 2015 | 26658124 |
| urinary tract infection among renal transplant recipients in yemen. | urinary tract infection (uti) is the most common complication following kidney transplantation (kt), which could result in losing the graft. this study aims to identify the prevalence of bacterial uti among kt recipients in yemen and to determine the predisposing factors associated with post renal transplantation uti. a cross sectional study included of 150 patients, who underwent kt was conducted between june 2010 and january 2011. a morning mid-stream urine specimen was collected for culture a ... | 2015 | 26657128 |
| complete genome sequence of the molybdenum-resistant bacterium bacillus subtilis strain lm 4-2. | bacillus subtilis lm 4-2, a gram-positive bacterium was isolated from a molybdenum mine in luoyang city. due to its strong resistance to molybdate and potential utilization in bioremediation of molybdate-polluted area, we describe the features of this organism, as well as its complete genome sequence and annotation. the genome was composed of a circular 4,069,266 bp chromosome with average gc content of 43.83 %, which included 4149 predicted orfs and 116 rna genes. additionally, 687 transporter- ... | 2015 | 26664656 |
| optimizing polymyxin combinations against resistant gram-negative bacteria. | polymyxin combination therapy is increasingly used clinically. however, systematic investigations of such combinations are a relatively recent phenomenon. the emerging pharmacodynamic (pd) and pharmacokinetic (pk) data on cms/colistin and polymyxin b suggest that caution is required with monotherapy. given this situation, polymyxin combination therapy has been suggested as a possible way to increase bacterial killing and reduce the development of resistance. considerable in vitro data have been ... | 2015 | 26645096 |
| an unusual case of hepatosplenic αβ t-cell lymphoma presenting with coombs'-negative hemolytic anemia. | hepatosplenic t-cell lymphoma (hstcl) is a rare and aggressive extranodal t-cell lymphoma that comprises <5% of peripheral t-cell lymphomas. the majority of cases harbor the γδ t-cell receptor (tcr), but recently, a few cases have been shown to express the αβ tcr. comparison of these two subtypes (αβ and γδ) shows similar clinicopathologic and cytogenetic features; however, due to the paucity of reported cases, it is not clear whether they are prognostically distinct entities. we report a case o ... | 2015 | 26688667 |
| synergic effects between ocellatin-f1 and bufotenine on the inhibition of bhk-21 cellular infection by the rabies virus. | rabies is an incurable neglected zoonosis with worldwide distribution characterized as a lethal progressive acute encephalitis caused by a lyssavirus. animal venoms and secretions have long been studied as new bioactive molecular sources, presenting a wide spectrum of biological effects, including new antiviral agents. bufotenine, for instance, is an alkaloid isolated from the skin secretion of the anuran rhinella jimi that inhibits cellular penetration by the rabies virus. antimicrobial peptide ... | 2015 | 26635873 |
| revealing the characteristics of a novel bioflocculant and its flocculation performance in microcystis aeruginosa removal. | in the present work, a novel bioflocculant, eps-1, was prepared and used to flocculate the kaolin suspension and microcystis aeruginosa. we focused on the characteristics and flocculation performance of eps-1, especially with regard to its protein components. an important attribute of eps-1 was its protein content, with 18 protein types identified that occupied a total content of 31.70% in the eps-1. moreover, the flocculating activity of these protein components was estimated to be no less than ... | 2015 | 26626432 |
| metagenomic sequencing of bile from gallstone patients to identify different microbial community patterns and novel biliary bacteria. | despite the high worldwide prevalence of gallstone disease, the role of the biliary microbiota in gallstone pathogenesis remains obscure. next-generation sequencing offers advantages for systematically understanding the human microbiota; however, there have been few such investigations of the biliary microbiome. here, we performed whole-metagenome shotgun (wms) sequencing and 16s rrna sequencing on bile samples from 15 chinese patients with gallstone disease. microbial communities of most indivi ... | 2015 | 26625708 |
| microbiology of chronic suppurative otitis media at queen elizabeth central hospital, blantyre, malawi: a cross-sectional descriptive study. | chronic suppurative otitis media (csom) is still a significant health problem in developing countries. therefore, it was pertinent to determine the local malawian microbiology in order to guide adequate treatment, avoid complications, and provide records for future reference. | 2015 | 26955432 |
| whence resistance? | antimicrobial resistance results from a complex interaction between pathogenic and non-pathogenic bacteria, antimicrobial pressure, and genes, which together comprise the total body of potential resistance elements. the purpose of this study is to review and evaluate the importance of antimicrobial pressure on the development of resistance in a single surgical intensive care unit. | 2015 | 26186101 |
| mother's milk as a source of enterobacter cloacae sepsis in a preterm infant. | 2015 | 26540337 | |
| editorial: luxr solos are becoming major players in cell-cell communication in bacteria. | 2015 | 26649284 | |
| vancomycin-associated nephrotoxicity: the obesity factor. | current recommendations suggest that vancomycin dosing utilize actual rather than ideal body weight in obese patients. thus, obese patients may be at greater risk for nephrotoxicity. the purpose of this study was to compare the incidence of nephrotoxicity in vancomycin-treated obese and lean patients at our institution, where unadjusted, actual body weight-based dosing (capped at 2 g per dose twice daily) is used. we expected obese patients to experience a greater incidence of nephrotoxicity tha ... | 2015 | 26324996 |
| identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities. | treating bacterial infections can be difficult due to innate or acquired resistance mechanisms, and the formation of biofilms. cyclic lipopeptides derived from fusaricidin/li-f natural products represent particularly attractive candidates for the development of new antibacterial and antibiofilm agents, with the potential to meet the challenge of bacterial resistance to antibiotics. a positional-scanning combinatorial approach was used to identify the amino acid residues responsible for driving a ... | 2015 | 26703794 |
| identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities. | treating bacterial infections can be difficult due to innate or acquired resistance mechanisms, and the formation of biofilms. cyclic lipopeptides derived from fusaricidin/li-f natural products represent particularly attractive candidates for the development of new antibacterial and antibiofilm agents, with the potential to meet the challenge of bacterial resistance to antibiotics. a positional-scanning combinatorial approach was used to identify the amino acid residues responsible for driving a ... | 2015 | 26703794 |
| discovery of a mcl-pha with unexpected biotechnical properties: the marine environment of french polynesia as a source for pha-producing bacteria. | a library of microorganisms originating from various marine environments in french polynesia was screened for polyhydroxyalkanoate producing bacteria. no significant connection was found between the geo-ecological source of bacteria and their ability to produce polyhydroxyalkanoate. a bacterial strain designated as enterobacter fak 1384 was isolated from a shark jaw. when grown on coprah oil, this bacterium produces a pha constituting of 62 mol % 3-hydroxydecanoate and lower amount of 12 mol % 3 ... | 2015 | 26606919 |
| first identification of an imi-1 carbapenemase-producing colistin-resistant enterobacter cloacae in china. | carbapenem resistance among the enterobacteriaceae is a serious healthcare challenge. bla imi is a carbapenemase gene mediating resistance to carbapenems but has not been commonly found. a bla imi-carrying enterobacter cloacae, which was also resistant to colistin, is reported here. | 2015 | 26607057 |
| prospective comparison of a pcr assay and a microbiological culture technique for identification of pathogens from blood and non-blood samples in septic patients. | molecular amplification techniques are suggested to be a useful adjunct in early detection of pathogens in septic patients. the aim was to study the feasibility of a polymerase chain reaction (pcr) assay compared to the standard microbiological culture (mc) technique in identification of pathogenic microorganisms from blood and non-blood samples in septic patients. | 2015 | 26594362 |
| local injection of aminoglycosides for prophylaxis against infection in open fractures. | the purpose of this study was to determine the efficacy of local wound cavity injections of aqueous aminoglycosides (gentamicin and tobramycin), in conjunction with systemic antibiotics, to lower the prevalence of infection in patients with open fractures. | 2015 | 26582614 |
| complex regulation pathways of ampc-mediated β-lactam resistance in enterobacter cloacae complex. | enterobacter cloacae complex (ecc), an opportunistic pathogen causing numerous infections in hospitalized patients worldwide, is able to resist β-lactams mainly by producing the ampc β-lactamase enzyme. ampc expression is highly inducible in the presence of some β-lactams, but the underlying genetic regulation, which is intricately linked to peptidoglycan recycling, is still poorly understood. in this study, we constructed different mutant strains that were affected in genes encoding enzymes sus ... | 2015 | 26438498 |
| genetic and biochemical characterization of fri-1, a carbapenem-hydrolyzing class a β-lactamase from enterobacter cloacae. | an enterobacter cloacae isolate was recovered from a rectal swab from a patient hospitalized in france with previous travel to switzerland. it was resistant to penicillins, narrow- and broad-spectrum cephalosporins, aztreonam, and carbapenems but remained susceptible to expanded-spectrum cephalosporins. whereas pcr-based identification of the most common carbapenemase genes failed, the biochemical carba np test ii identified an ambler class a carbapenemase. cloning experiments followed by sequen ... | 2015 | 26392482 |
| clonal dissemination of enterobacter cloacae harboring blakpc-3 in the upper midwestern united states. | carbapenemase-producing, carbapenem-resistant enterobacteriaceae, or cp-cre, are an emerging threat to human and animal health, because they are resistant to many of the last-line antimicrobials available for disease treatment. carbapenemase-producing enterobacter cloacae harboring blakpc-3 recently was reported in the upper midwestern united states and implicated in a hospital outbreak in fargo, north dakota (l. m. kiedrowski, d. m. guerrero, f. perez, r. a. viau, l. j. rojas, m. f. mojica, s. ... | 2015 | 26438492 |
| characterization of tn3000, a transposon responsible for blandm-1 dissemination among enterobacteriaceae in brazil, nepal, morocco, and india. | in enterobacteriaceae, the blandm genes have been found in many different genetic contexts, and a wide diversity of plasmid scaffolds bearing those genes has been found. in august 2013, we identified ndm-1-producing escherichia coli and enterobacter hormaechei strains from a single rectal swab sample from a patient hospitalized in rio de janeiro, brazil, who had no history of travel abroad. complete dna sequencing using the illumina platform and annotation of the two plasmids harboring the bland ... | 2015 | 26392506 |
| cefepime therapy for monomicrobial enterobacter cloacae bacteremia: unfavorable outcomes in patients infected by cefepime-susceptible dose-dependent isolates. | a new category of cefepime susceptibility, susceptible dose dependent (sdd), for enterobacteriaceae, has been suggested to maximize its clinical use. however, clinical evidence supporting such a therapeutic strategy is limited. a retrospective study of 305 adults with monomicrobial enterobacter cloacae bacteremia at a medical center from 2008 to 2012 was conducted. the patients definitively treated with in vitro active cefepime (cases) were compared with those treated with a carbapenem (controls ... | 2015 | 26416853 |
| in vitro activities of novel antimicrobial combinations against extensively drug-resistant acinetobacter baumannii. | extensively drug-resistant (xdr) acinetobacter spp. have emerged as a cause of nosocomial infections, especially under conditions of intensive care. unfortunately, resistance to colistin is increasing and there is a need for new therapeutic options. we aimed to study the effect of some novel combinations against xdr acinetobacter baumannii in an in vitro pharmacokinetics-pharmacodynamics (pk/pd) model. three nonrelated clinical strains of xdr a. baumannii were investigated. antibiotic-simulated ... | 2015 | 26369956 |
| impact of a modified broviac maintenance care bundle on bloodstream infections in paediatric cancer patients. | during intensive chemotherapy, bloodstream infection (bsi) represents an important complication in paediatric cancer patients. most patients carry a long-term central venous access device (cvad). improved maintenance care of these vascular catheters may decrease the risk of bsi. | 2015 | 26605135 |
| risk factors, management, and prognosis for liver abscess after radical resection of hilar cholangiocarcinoma. | pyogenic liver abscess (pla) is a rare but potentially lethal infectious complication after radical surgical resection of hilar cholangiocarcinoma (hc), this study is aimed to identify the risk factors, management and prognosis of pla after curative surgical resection of hc. | 2015 | 26885067 |
| genome sequence and description of pantoea septica strain ff5. | strain ff5 was isolated from the skin flora of a healthy senegalese 35-year-old woman. this strain was identified as belonging to the species pantoea septica based on rpob sequence identity of 99.7 % with pantoea septica strain lmg 5345(t) and a highest maldi-tof-ms score of 2.3 with pantoea septica. like p. septica, this ff5 strain is a gram-negative, aerobic, motile, and rod-shaped bacterium. currently, 17 genomes have been sequenced within the genus pantoea but none for pantoea septica. herei ... | 2015 | 26568786 |
| about the usefulness of contact precautions for carriers of extended-spectrum beta-lactamase-producing escherichia coli. | extended-spectrum β-lactamases producing escherichia coli (esbl-e) are increasingly identified in health care facilities. as previously done for the control of methicillin-resistant staphylococcus aureus, many hospitals have established screening strategies for early identification of patients being carriers of esbl producers in general and esbl-e in particular, and have implemented contact precautions (cp) for infected and colonized patients. | 2015 | 26563141 |
| larval ecology of anopheles coluzzii in cape coast, ghana: water quality, nature of habitat and implication for larval control. | there is a growing interest in larval control intervention to supplement existing malaria control strategies, particularly in urban areas. however, effective implementation requires a good understanding of habitat ecology of anopheles mosquitoes. clean water bodies have long been reported by several studies as a preferred breeding habitat for anopheles gambiae. other studies have also reported the breeding of an. gambiae in polluted water bodies. however, the term clean or polluted is mostly bas ... | 2015 | 26558365 |
| association of antibiotic resistance with shv-12 extended-spectrum β-lactamase in enterobacter cloacae. | the association between antibiotic resistance and shv-12 extended-spectrum β-lactamase (esbl) in enterobacter cloacae remains unknown. the aim of the present study was to investigate the prevalence of both chromosome- and plasmid-borne shv-12 esbl genes in enterobacter cloacae. transmission of the shv-12 esbl gene was explored, and the risk factors for antibiotic resistance in e. cloacae were analyzed. polymerase chain reaction (pcr) results showed that 58 out of the 100 isolates carried the shv ... | 2015 | 26889253 |
| association of antibiotic resistance with shv-12 extended-spectrum β-lactamase in enterobacter cloacae. | the association between antibiotic resistance and shv-12 extended-spectrum β-lactamase (esbl) in enterobacter cloacae remains unknown. the aim of the present study was to investigate the prevalence of both chromosome- and plasmid-borne shv-12 esbl genes in enterobacter cloacae. transmission of the shv-12 esbl gene was explored, and the risk factors for antibiotic resistance in e. cloacae were analyzed. polymerase chain reaction (pcr) results showed that 58 out of the 100 isolates carried the shv ... | 2015 | 26889253 |
| the functionality of the gastrointestinal microbiome in non-human animals. | due to the significance of the microbiome on human health, much of the current data available regarding microbiome functionality is centered on human medicine. for agriculturally important taxa, the functionality of gastrointestinal bacteria has been studied with the primary goals of improving animal health and production performance. with respect to cattle, the digestive functions of bacteria in cattle are unarguably critical to digestion and positively impact production performance. conversely ... | 2015 | 26552373 |
| use of ward closure to control outbreaks among hospitalized patients in acute care settings: a systematic review. | though often used to control outbreaks, the efficacy of ward closure is unclear. this systematic review sought to identify studies defining and describing ward closure in outbreak control and to determine impact of ward closure as an intervention on outbreak containment. | 2015 | 26546048 |
| the effect of tellurite on highly resistant freshwater aerobic anoxygenic phototrophs and their strategies for reduction. | six fresh water aerobic anoxygenic phototrophs (erythromicrobium ezovicum, strain e1; erythromicrobium hydrolyticum, e4(1); erythromicrobium ramosum, e5; erythromonas ursincola, kr99; sandaracinobacter sibiricus, rb 16-17; and roseococcus thiosulfatophilus, rb3) possessing high level resistance to teo₃(2-) and the ability to reduce it to elemental te were studied to understand their interaction with this highly toxic oxyanion. tested organic carbon sources, ph, and level of aeration all had an i ... | 2015 | 27682119 |
| multicenter study of combination dep regimen as a salvage therapy for adult refractory hemophagocytic lymphohistiocytosis. | hemophagocytic lymphohistiocytosis (hlh) is a refractory immune disorder with a significant risk of death. although standard therapy has dramatically improved survival in hlh patients, approximately 30%, especially adults, show no response to current treatment strategies. this prospective study aimed to investigate the efficacy of liposomal doxorubicin treatment combined with etoposide and methylprednisolone (doxorubicin-etoposide-methylprednisolone; dep) as a salvage therapy for adult refractor ... | 2015 | 26289641 |
| sucupira as a potential plant for arthritis treatment and other diseases. | trees of the genus pterodon, commonly known as "sucupira-branca" or "faveira," are native to central brazil. the pterodon fruits are traditionally used in ethnomedicine as an infusion, in small doses, and at regular time intervals as an antirheumatic, anti-inflammatory, tonic, and depurative agent. the various compounds present in the pterodon class are, generally, water-insoluble and derived from the fusion of high-molecular weight pentacarbonate units. scientific research has shown that the ma ... | 2015 | 26613051 |
| inner workings: taking evolution to the clinic. | 2015 | 26534990 | |
| microbiota and host immune responses: a love-hate relationship. | a complex relationship between the microbiota and the host emerges early at birth and continues throughout life. the microbiota includes the prokaryotes, viruses and eukaryotes living among us, all of which interact to different extents with various organs and tissues in the body, including the immune system. although the microbiota is most dense in the lower intestine, its influence on host immunity extends beyond the gastrointestinal tract. these interactions with the immune system operate thr ... | 2015 | 26439191 |
| microbiota and host immune responses: a love-hate relationship. | a complex relationship between the microbiota and the host emerges early at birth and continues throughout life. the microbiota includes the prokaryotes, viruses and eukaryotes living among us, all of which interact to different extents with various organs and tissues in the body, including the immune system. although the microbiota is most dense in the lower intestine, its influence on host immunity extends beyond the gastrointestinal tract. these interactions with the immune system operate thr ... | 2015 | 26439191 |
| cellular defense and sensory cell survival require distinct functions of ebi in drosophila. | the innate immune response and stress-induced apoptosis are well-established signaling pathways related to cellular defense. nf-κb and ap-1 are redox-sensitive transcription factors that play important roles in those pathways. here we show that ebi, a drosophila homolog of the mammalian co-repressor molecule transducin β-like 1 (tbl1), variously regulates the expression of specific genes that are targets of redox-sensitive transcription factors. in response to different stimuli, ebi activated ge ... | 2015 | 26524764 |
| virulence potential of activatable shiga toxin 2d-producing escherichia coli isolates from fresh produce. | shiga toxin (stx)-producing escherichia coli (stec) strains are food- and waterborne pathogens that are often transmitted via beef products or fresh produce. stec strains cause both sporadic infections and outbreaks, which may result in hemorrhagic colitis and hemolytic uremic syndrome. stec strains may elaborate stx1, stx2, and/or subtypes of those toxins. epidemiological evidence indicates that stec that produce subtypes stx2a, stx2c, and/or stx2d are more often associated with serious illness ... | 2015 | 26555533 |
| bacteriological profile and antimicrobial susceptibility pattern of blood culture isolates among septicemia suspected children in selected hospitals addis ababa, ethiopia. | blood stream infections are major cause of morbidity and mortality in children in developing countries. the emerging of causative agents and resistance to various antimicrobial agents are increased from time to time. the main aim of this study was to determine the bacterial agents and antimicrobial susceptibility patterns among children suspected of having septicemia. | 2015 | 26997847 |
| in vitro screening for antioxidant, antimicrobial, and antidiabetic properties of some korean native plants on mt. halla, jeju island. | in this study, prunus padus, lonicera caerulea, berberis amurensis, and ribes maximowiczianum, which are mainly distributed on mt. halla, jeju island, have been investigated for their antioxidant, antimicrobial, and antidiabetic activities. the methanol extracts of r. maximowiczianum leaves and p. padus branches exhibited significant and dose-dependent antioxidant activity including electron-donation ability and reducing power. to analyze the antimicrobial activity, each extract was tested by a ... | 2015 | 26997693 |
| ceftaroline fosamil use in 2 pediatric patients with invasive methicillin-resistant staphylococcus aureus infections. | community-associated methicillin-resistant staphylococcus aureus (ca-mrsa) is one of the most common pathogens causing pediatric infections including skin and soft tissue infections, pyogenic arthritis, osteomyelitis, and septic shock. for decades, patients were treated with antibiotics such as vancomycin and clindamycin, but there is an increasing incidence of resistance to these traditional therapies. we describe 2 cases of patients with ca-mrsa invasive infections with bacteremia who experien ... | 2015 | 26766937 |
| negative pressure incision management system in the prevention of groin wound infection in vascular surgery patients. | objectives. groin wounds following vascular surgery are highly susceptible to healing disturbances, with reported site infections reaching 30%. negative pressure incision management systems (npims) are believed to positively influence the prevention of surgical wound-healing disturbances (whd) and surgical site infections (ssi). npims placed directly after closure of the surgical wound is thought to result in fewer infections; we analysed its effect on postoperative wound infections in patients ... | 2015 | 26609543 |
| outbreak breakthrough: using whole-genome sequencing to control hospital infection. | 2015 | 26523889 | |
| human norovirus culture in b cells. | human noroviruses (hunovs) are a leading cause of foodborne disease and severe childhood diarrhea, and they cause a majority of the gastroenteritis outbreaks worldwide. however, the development of effective and long-lasting hunov vaccines and therapeutics has been greatly hindered by their uncultivability. we recently demonstrated that a hunov replicates in human b cells, and that commensal bacteria serve as a cofactor for this infection. in this protocol, we provide detailed methods for culturi ... | 2015 | 26513671 |
| microbial contaminants of cord blood units identified by 16s rrna sequencing and by api test system, and antibiotic sensitivity profiling. | over a period of ten months a total of 5618 cord blood units (cbu) were screened for microbial contamination under routine conditions. the antibiotic resistance profile for all isolates was also examined using atb strips. the detection rate for culture positive units was 7.5%, corresponding to 422 samples.16s rrna sequence analysis and identification with api test system were used to identify the culturable aerobic, microaerophilic and anaerobic bacteria from cbus. from these samples we recovere ... | 2015 | 26512991 |
| intestinal carriage of carbapenemase-producing organisms: current status of surveillance methods. | carbapenemases have become a significant mechanism for broad-spectrum β-lactam resistance in enterobacteriaceae and other gram-negative bacteria such as pseudomonas and acinetobacter spp. intestinal carriage of carbapenemase-producing organisms (cpos) is an important source of transmission. isolation of carriers is one strategy that can be used to limit the spread of these bacteria. in this review, we critically examine the clinical performance, advantages, and disadvantages of methods available ... | 2015 | 26511484 |
| intestinal carriage of carbapenemase-producing organisms: current status of surveillance methods. | carbapenemases have become a significant mechanism for broad-spectrum β-lactam resistance in enterobacteriaceae and other gram-negative bacteria such as pseudomonas and acinetobacter spp. intestinal carriage of carbapenemase-producing organisms (cpos) is an important source of transmission. isolation of carriers is one strategy that can be used to limit the spread of these bacteria. in this review, we critically examine the clinical performance, advantages, and disadvantages of methods available ... | 2015 | 26511484 |
| influx of multidrug-resistant organisms by country-to-country transfer of patients. | multidrug-resistant organisms (mdro) are a worldwide problem. international migration and travel facilitate the spread of mdro. therefore the goal of our study was to assess the risk of influx of mdro from patients transferred to one of central europe's largest hospitals from abroad. | 2015 | 26508038 |
| light-driven biocatalytic reduction of α,β-unsaturated compounds by ene reductases employing transition metal complexes as photosensitizers. | efficient and cost effective nicotinamide cofactor regeneration is essential for industrial-scale bio-hydrogenations employing flavin-containing biocatalysts such as the old yellow enzymes. a direct flavin regeneration system using visible light to initiate a photoredox cycle and drive biocatalysis is described, and shown to be effective in driving biocatalytic activated alkene reduction. using ru(ii) or ir(iii) complexes as photosensitizers, coupled with an electron transfer mediator (methyl vi ... | 2015 | 27019691 |
| light-driven biocatalytic reduction of α,β-unsaturated compounds by ene reductases employing transition metal complexes as photosensitizers. | efficient and cost effective nicotinamide cofactor regeneration is essential for industrial-scale bio-hydrogenations employing flavin-containing biocatalysts such as the old yellow enzymes. a direct flavin regeneration system using visible light to initiate a photoredox cycle and drive biocatalysis is described, and shown to be effective in driving biocatalytic activated alkene reduction. using ru(ii) or ir(iii) complexes as photosensitizers, coupled with an electron transfer mediator (methyl vi ... | 2015 | 27019691 |
| length of preoperative hospital stay: a risk factor for reducing surgical infection in femoral fracture cases. | to analyze infections of the surgical site among patients undergoing clean-wound surgery for correction of femoral fractures. | 2015 | 27218074 |
| clinical characteristics and treatment of extremity chronic osteomyelitis in southern china: a retrospective analysis of 394 consecutive patients. | although extremity chronic osteomyelitis is common in china, updated data were still limited regarding its characterizations. the present study aimed to review clinical features of extremity chronic osteomyelitis in southern china.a retrospective analysis was conducted in the patients who had sought medical attention from january 2010 to april 2015 for extremity chronic osteomyelitis in nanfang hospital in southern china. clinical data were collected and analyzed.a total of 394 patients (307 mal ... | 2015 | 26496345 |
| fluoroquinolone resistance mechanisms and population structure of enterobacter cloacae non-susceptible to ertapenem in north-eastern france. | fluoroquinolone (fq) agents are a potential resort to treat infection due to enterobacteriaceae producing extended spectrum β-lactamase and susceptible to fq. in a context of increase of non-susceptibility to carbapenems among enterobacteriaceae, we characterized fq resistance mechanisms in 75 enterobacter cloacae isolates non-susceptible to ertapenem in north-eastern france in 2012 and describe the population structure by pulsed field gel electrophoresis (pfge) and multi-locus sequence typing ( ... | 2015 | 26557115 |
| [bacteriological characteristics of the peritoneal dialysis fluid infections]. | 2015 | 26893796 | |
| analysis of glycosylated hemoglobin (hba1c) level on maxillofacial fascial space infection in diabetic patients. | this study was performed to evaluate the impact of glycosylated hemoglobin (hba1c) level on characteristics and prognosis of maxillofacial fascial infection in diabetic patients. | 2015 | 26568927 |
| assessment of the antimicrobial activity of algae extracts on bacteria responsible of external otitis. | external otitis is a diffuse inflammation around the external auditory canal and auricle, which is often occurred by microbial infection. this disease is generally treated using antibiotics, but the frequent occurrence of antibiotic resistance requires the development of new antibiotic agents. in this context, unexplored bioactive natural candidates could be a chance for the production of targeted drugs provided with antimicrobial activity. in this paper, microbial pathogens were isolated from p ... | 2015 | 26492256 |
| structural insights into the mmachc-mmadhc protein complex involved in vitamin b12 trafficking. | conversion of vitamin b12 (cobalamin, cbl) into the cofactor forms methyl-cbl (mecbl) and adenosyl-cbl (adocbl) is required for the function of two crucial enzymes, mitochondrial methylmalonyl-coa mutase and cytosolic methionine synthase, respectively. the intracellular proteins mmachc and mmadhc play important roles in processing and targeting the cbl cofactor to its destination enzymes, and recent evidence suggests that they may interact while performing these essential trafficking functions. ... | 2015 | 26483544 |
| synthesis and evaluation of biological activity of antimicrobial--pro-proliferative peptide conjugates. | skin represents the largest organ of the human body and plays a crucial role in its protection from the negative impact of the outside environment, maintains its homeostasis, enables sensory interaction and thermoregulation. the traumatized skin tissue undergoes several phenotype switches due to progressive reoxygenation and release of cytokine and growth factors, that activate mechanisms of reparative processes. however, in case of wounds colonized with pathogenic microflora natural regenerativ ... | 2015 | 26473368 |
| pathogen distribution and drug resistance in a burn ward: a three-year retrospective analysis of a single center in china. | to investigate the spread of multiple-resistant strain in a burn ward to inform clinical administration of antibiotic drugs, burn wound treatment and decision-making for infection control. a 3-year retrospective analysis was conducted. specimens from wounds, blood, catheter, sputum, urine and stool collected from inpatients of the second affiliated hospital of zhejiang university of medicine between january 1, 2011 and december 31, 2013 were cultured and strains were identified by automatic bact ... | 2015 | 26770555 |
| chemical conjugation of 2-hexadecynoic acid to c5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria. | the first total synthesis of a c5-curcumin-2-hexadecynoic acid (c5-curc-2-hda, 6) conjugate was successfully performed. through a three-step synthetic route, conjugate 6 was obtained in 13% overall yield and tested for antibacterial activity against methicillin-resistant staphylococcus aureus (mrsa) strains. our results revealed that 6 was active against eight mrsa strains at mics that range between 31.3 and 62.5 μg/ml. it was found that the presence of 2-hexadecynoic acid (2-hda, 4) in conjugat ... | 2015 | 26483137 |
| recent advances in engineering topography mediated antibacterial surfaces. | the tendency of bacterial cells to adhere and colonize a material surface leading to biofilm formation is a fundamental challenge underlying many different applications including microbial infections associated with biomedical devices and products. although, bacterial attachment to surfaces has been extensively studied in the past, the effect of surface topography on bacteria-material interactions has received little attention until more recently. we review the recent progress in surface topogra ... | 2015 | 26372264 |
| sepsis in hemodialysis patients. | bacterial infections are very common in end stage renal disease (esrd) patients. the diagnosis of sepsis in such patients is often challenging and requires a high index of suspicion. the aim of this study is to report on a series of patient with esrd on hemodialysis (hd) diagnosed with sepsis. | 2015 | 26467100 |
| clinical severity of pediatric respiratory illness with enterovirus d68 compared with rhinovirus or other enterovirus genotypes. | enterovirus d68 (ev-d68) resulted in a reported increase in the number of children needing hospital or critical care admission because of respiratory insufficiency during 2014. it remains unclear, however, whether ev-d68 infections were more severe than rhinovirus or non-ev-d68 enterovirus infections. | 2015 | 26464137 |
| clinical outcomes associated with polymyxin b dose in patients with bloodstream infections due to carbapenem-resistant gram-negative rods. | there is significant variation in the use of polymyxin b (pmb), and optimal dosing has not been defined. the purpose of this retrospective study was to evaluate the relationship between pmb dose and clinical outcomes. we included patients with bloodstream infections (bsis) due to carbapenem-resistant gram-negative rods who received ≥48 h of intravenous pmb. the objective was to evaluate the association between pmb dose and 30-day mortality, clinical cure at day 7, and development of acute kidney ... | 2015 | 26324272 |
| emergence of raoultella ornithinolytica coproducing imp-4 and kpc-2 carbapenemases in china. | we report here the emergence of seven imp-4-producing raoultella ornithinolytica isolates obtained from one patient. all isolates carried the blaimp-4 carbapenemase gene, five isolates also carried blashv-12, four contained blatem-1, and one contained blaoxa-1. notably, the r. ornithinolytica isolate ro25724 also expressed klebsiella pneumoniae carbapenemase (kpc)-2. the blakpc-2 gene was located on a tn3-tn4401 integration structure on a plasmid of ∼450 kb. this is the first description of the ... | 2015 | 26282422 |
| dissemination of carbapenemase-producing enterobacteriaceae and pseudomonas aeruginosa in romania. | fifteen carbapenemase-producing enterobacteriaceae isolates and 12 carbapenemase-producing pseudomonas aeruginosa isolates were recovered from patients hospitalized between august 2011 and march 2013 at the hospital of infectious disease, cluj-napoca, romania. one kpc-, nine ndm-1-, four oxa-48-, and one vim-4-producing enterobacteriaceae isolates along with 11 vim-2-producing and one imp-13-producing p. aeruginosa isolates were recovered from clinical samples. all carbapenemase genes were locat ... | 2015 | 26303798 |
| outbreak caused by enterobacteriaceae harboring ndm-1 metallo-β-lactamase carried in an incfii plasmid in a tertiary care hospital in mexico city. | carbapenem-resistant enterobacteriaceae carrying new delhi metallo-β-lactamase 1 (ndm-1) have rarely been reported in latin america. we report of an outbreak caused by a blandm-1-harboring plasmid spread through different bacterial species, including escherichia coli (st617) and enterobacter cloacae (st182) isolates from the same patient and three klebsiella pneumoniae isolates (st22) derived from three epidemiologically related patients. incfii plasmids were found in all strains. measures to co ... | 2015 | 26282410 |