Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| aspergillus fumigatus spinal abscess in an immunocompetent child. | 2015 | 26208570 | |
| isolated enteric aspergillosis in a non severely immunocompromised patient. case report and literature review. | invasive aspergillosis is a life-threatening, opportunistic fungal infection that mainly affects immunocompromised patients, particularly those receiving immunosuppressive therapy or high-dose corticosteroids. the most common portal of entry in aspergillosis is the lung, so the isolated occurrence of intestinal aspergillosis in the absence of pulmonary disease is an unusual pattern. | 2015 | 26206431 |
| cell wall proteome of pathogenic fungi. | a fast development of a wide variety of proteomic techniques supported by mass spectrometry coupled with high performance liquid chromatography has been observed in recent years. it significantly contributes to the progress in research on the cell wall, very important part of the cells of pathogenic fungi. this complicated structure composed of different polysaccharides, proteins, lipids and melanin, plays a key role in interactions with the host during infection. changes in the set of the surfa ... | 2015 | 26192771 |
| in vitro antifungal activity and mode of action of 2',4'-dihydroxychalcone against aspergillus fumigatus. | 2',4'-dihydroxychalcone (2',4'-dhc) was identified from a heat shock protein 90 (hsp90)-targeting library as a compound with hsp90 inhibitory and antifungal effects. in the presence of 2',4'-dhc (8 µg/ml), radial growth of aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked. the expression of the conidiation-associated genes abaa, brla, and weta was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-dhc. the exp ... | 2015 | 26190922 |
| recombination detection in aspergillus fumigatus through single nucleotide polymorphisms typing. | the first evidence of sexual reproduction in aspergillus fumigatus was reported in 2009. nevertheless, it remains difficult to understand how a. fumigatus is able to reproduce through this mode in its natural environment and how frequently this occurs. the aim of this study was to analyse single nucleotide polymorphisms (snps) in a set of environmental and clinical isolates of a. fumigatus to detect signatures of recombination. a group of closely related portuguese a. fumigatus isolates was char ... | 2015 | 26189756 |
| clinical-scale isolation of the total aspergillus fumigatus-reactive t-helper cell repertoire for adoptive transfer. | evidence of the criticality of the adaptive immune response for controlling invasive aspergillosis has been provided. this observation is supported by the fact that invasive aspergillosis, a grave complication of allogeneic stem cell transplantation, occurs long after myeloid reconstitution in patients with low t-cell engraftment and/or on immunosuppressants. adoptive t-cell transfer might be beneficial, but idiosyncrasies of aspergillus fumigatus and the anti-aspergillus immune response render ... | 2015 | 26188965 |
| t helper 2 response in allergic bronchopulmonary aspergillosis is not driven by specific aspergillus antigens. | allergic bronchopulmonary aspergillosis (abpa) is characterized by an allergic immunological response to aspergillus fumigatus. in this study, we investigated whether certain aspergillus antigens are more allergenic than others, as was postulated previously. we stimulated peripheral blood mononuclear cells from patients with abpa with the classically described a. fumigatus allergens aspf1, aspf2, aspf3, and aspf4, as well as two other aspergillus antigens, crf1 and catalase1. activated cd4+ t ce ... | 2015 | 26179335 |
| [retraction. allergic bronchopulmonary aspergillosis in refractory asthma: about a case report]. | 2015 | 26175839 | |
| erratum for abdolrasouli et al., genomic context of azole resistance mutations in aspergillus fumigatus determined using whole-genome sequencing. | 2015 | 26173700 | |
| caspofungin treatment of aspergillus fumigatus results in chsg-dependent upregulation of chitin synthesis and the formation of chitin-rich microcolonies. | treatment of aspergillus fumigatus with echinocandins such as caspofungin inhibits the synthesis of cell wall β-1,3-glucan, which triggers a compensatory stimulation of chitin synthesis. activation of chitin synthesis can occur in response to sub-mics of caspofungin and to cacl2 and calcofluor white (cfw), agonists of the protein kinase c (pkc), and ca(2+)-calcineurin signaling pathways. a. fumigatus mutants with the chs gene (encoding chitin synthase) deleted (δafchs) were tested for their resp ... | 2015 | 26169407 |
| probiotic potential of lactobacillus strains with antifungal activity isolated from animal manure. | the aim of the study was to isolate and characterize the lactic acid bacteria (lab) from animal manure. among the thirty lab strains, four strains, namely, kcc-25, kcc-26, kcc-27, and kcc-28, showed good cell growth and antifungal activity and were selected for further characterization. biochemical and physiology properties of strains confirmed that the strains are related to the lactobacillus sp.; further, the 16s rrna sequencing confirmed 99.99% sequence similarity towards lactobacillus planta ... | 2015 | 26167534 |
| absence of fungal spore internalization by bronchial epithelium in mouse models evidenced by a new bioimaging approach and transmission electronic microscopy. | clinical data and experimental studies suggest that bronchial epithelium could serve as a portal of entry for invasive fungal infections. we therefore analyzed the interactions between molds and the bronchial/bronchiolar epithelium at the early steps after inhalation. we developed invasive aspergillosis (aspergillus fumigatus) and mucormycosis (lichtheimia corymbifera) murine models that mimic the main clinical risk factors for these infections. histopathology studies were completed with a speci ... | 2015 | 26165863 |
| high prevalence of azole resistance in aspergillus fumigatus isolates from high-risk patients. | aspergillus fumigatus is the leading cause of invasive aspergillosis. adequate treatment is complicated by an increase in azole resistance. here, the incidence of voriconazole, posaconazole and itraconazole resistance in clinical isolates from high-risk patients from either the haematology ward or the icu of the university medical center utrecht in the period 2011-13 is analysed. putative clonality of resistant strains was tested through cyp51a and microsatellite typing. | 2015 | 26163402 |
| analysis of the aspergillus fumigatus biofilm extracellular matrix by solid-state nuclear magnetic resonance spectroscopy. | aspergillus fumigatus is commonly responsible for lethal fungal infections among immunosuppressed individuals. a. fumigatus forms biofilm communities that are of increasing biomedical interest due to the association of biofilms with chronic infections and their increased resistance to antifungal agents and host immune factors. understanding the composition of microbial biofilms and the extracellular matrix is important to understanding function and, ultimately, to developing strategies to inhibi ... | 2015 | 26163318 |
| aspergillus fumigatus enhances elastase production in pseudomonas aeruginosa co-cultures. | in the cystic fibrosis (cf) lung the presence of bacteria and fungi in the airways promotes an inflammatory response causing progressive lung damage, ultimately leading to high rates of morbidity and mortality. we hypothesized that polymicrobial interactions play an important role in promoting airway pathogenesis. we therefore examined the interplay between the most commonly isolated bacterial cf pathogen, pseudomonas aeruginosa, and the most prevalent filamentous fungi, aspergillus fumigatus, t ... | 2015 | 26162475 |
| [invasive aspergillosis sinusitis in a diabetic]. | 2015 | 26161202 | |
| synthesis, in vitro and in silico studies of some novel 5-nitrofuran-2-yl hydrazones as antimicrobial and antitubercular agents. | in this study, we synthesized two series of novel 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e in addition to a third series of thiophene-2-carbohydrazides 23a-g to develop potent antimicrobial and/or antitubercular agents. the newly synthesized compounds were evaluated in vitro for their antimicrobial and antimycobacterial activities. most of the 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e displayed variable activity against aspergillus fumigates, staphylococcus aureus, streptococcus pneum ... | 2015 | 26155871 |
| phytase production through response surface methodology and molecular characterization of aspergillus fumigatus nf191. | phytase play an important role in phytic acid catalysis that act as a food inhibitor in cereals. here, we isolated high phytase producing isolates nf191 closely related to aspergillus fumigatus sp. from piggery soil. dna was isolated from the fungal culture and amplified the its region using its1 and its4 primer using pcr. the 400-900 bp amplicon was gel eluted and subjected to sequencing. the sequencing results were assembled and compared with ncbi data base which showed the 99% identity of asp ... | 2015 | 26155674 |
| invasive fungal sinusitis involving the orbital apex in a patient with chronic renal failure. | an 82-year-old man with chronic renal failure presented with invasive fungal sinusitis involving the right orbital apex. intravenous liposomal amphotericin b was immediately administered with an intravenous sodium supplement. subsequently, endoscopic sinus surgery was performed. aspergillus fumigatus was detected in nasal discharge culture on day 12. because the patient's renal function had deteriorated by this time, therapy was changed to nasal inhalation of amphotericin b, which was discontinu ... | 2015 | 27928353 |
| interplay between gliotoxin resistance, secretion, and the methyl/methionine cycle in aspergillus fumigatus. | mechanistic studies on gliotoxin biosynthesis and self-protection in aspergillus fumigatus, both of which require the gliotoxin oxidoreductase glit, have revealed a rich landscape of highly novel biochemistries, yet key aspects of this complex molecular architecture remain obscure. here we show that an a. fumigatus δglia strain is completely deficient in gliotoxin secretion but still retains the ability to efflux bisdethiobis(methylthio)gliotoxin (bmgt). this correlates with a significant increa ... | 2015 | 26150413 |
| a novel mycovirus from aspergillus fumigatus contains four unique dsrnas as its genome and is infectious as dsrna. | we report the discovery and characterization of a double-stranded rna (dsrna) mycovirus isolated from the human pathogenic fungus aspergillus fumigatus, aspergillus fumigatus tetramycovirus-1 (afutmv-1), which reveals several unique features not found previously in positive-strand rna viruses, including the fact that it represents the first dsrna (to our knowledge) that is not only infectious as a purified entity but also as a naked dsrna. the afutmv-1 genome consists of four capped dsrnas, the ... | 2015 | 26139522 |
| h-ficolin binds aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses. | aspergillus fumigatus is an opportunistic fungal pathogen that typically infects the lungs of immunocompromised patients leading to a high mortality. h-ficolin, an innate immune opsonin, is produced by type ii alveolar epithelial cells and could participate in lung defences against infections. here, we used the human type ii alveolar epithelial cell line, a549, to determine the involvement of h-ficolin in fungal defence. additionally, we investigated the presence of h-ficolin in bronchoalveolar ... | 2015 | 26133042 |
| in vitro antifungal activity of some traditional persian medicinal plants on pathogenic fungi. | to investigate the antifungal activities of the extracts and sub-fractions of phlomis olivieri, verbascum speciosum, sambucus ebulus and erigeron hyrcanicus, four persian medicinal plants used in iranian folk medicine. | 2015 | 26129901 |
| characterization and genetic variability of feed-borne and clinical animal/human aspergillus fumigatus strains using molecular markers. | aspergillus fumigatus, the major etiological agent of human and animal aspergillosis, is a toxigenic fungus largely regarded as a single species by macroscopic and microscopic features. however, molecular studies have demonstrated that several morphologically identified a. fumigatus strains might be genetically distinct. this work was aimed to apply pcr-restriction length fragment polymorphisms (pcr-rflp) and random amplification of polymorphic dna (rapd) molecular markers to characterize a set ... | 2015 | 26129892 |
| combining standard clinical methods with pcr showed improved diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia. | we assessed the diagnostic value of standard clinical methods and combined biomarker testing (galactomannan assay and polymerase chain reaction screening) in a prospective case-control study to detect invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia. | 2015 | 26126706 |
| case of seropositive allergic bronchopulmonary aspergillosis in a 10-year-old girl without previously documented asthma. | allergic bronchopulmonary aspergillosis (abpa) is a hypersensitivity lung disease due to bronchial colonization of aspergillus fumigatus that occurs in susceptible patients with asthma or cystic fibrosis. a 10-year-old girl was referred to the department of pediatric pulmonology for persistent consolidations on chest radiography. pulmonary consolidations were observed in the right upper and left lower lobes and were not resolved with a 4-week prescription of broad-spectrum antibiotics. the patie ... | 2015 | 26124850 |
| evolution of the immune response to chronic airway colonization with aspergillus fumigatus hyphae. | airway colonization by the mold aspergillus fumigatus is common in patients with underlying lung disease and is associated with chronic airway inflammation. studies probing the inflammatory response to colonization with a. fumigatus hyphae have been hampered by the lack of a model of chronic colonization in immunocompetent mice. by infecting mice intratracheally with conidia embedded in agar beads (af beads), we have established an in vivo model to study the natural history of airway colonizatio ... | 2015 | 26123803 |
| rubicon swaps autophagy for lap. | phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called lc3-associated phagocytosis (lap). light has now been shed on the molecular requirements of lap, establishing a central role for the protein rubicon in the immune response to aspergillus fumigatus. | 2015 | 26123110 |
| update on antifungal drug resistance. | invasive fungal infections remain a major source of global morbidity and mortality, especially among patients with underlying immune suppression. successful patient management requires antifungal therapy. yet, treatment choices are restricted due to limited classes of antifungal agents and the emergence of antifungal drug resistance. in some settings, the evolution of multidrug-resistant strains insensitive to several classes of antifungal agents is a major concern. the resistance mechanisms res ... | 2015 | 26120512 |
| molecular-based allergy diagnosis of allergic bronchopulmonary aspergillosis in aspergillus fumigatus-sensitized japanese patients. | distinguishing between patients with allergic bronchopulmonary aspergillosis (abpa) and aspergillus fumigatus (af)-sensitized asthmatic patients without abpa is sometimes difficult owing to the ige-cross-reactivity between af and other fungal allergens. | 2015 | 26118958 |
| functional analysis of sterol transporter orthologues in the filamentous fungus aspergillus nidulans. | polarized growth in filamentous fungi needs a continuous supply of proteins and lipids to the growing hyphal tip. one of the important membrane compounds in fungi is ergosterol. at the apical plasma membrane ergosterol accumulations, which are called sterol-rich plasma membrane domains (srds). the exact roles and formation mechanism of the srds remained unclear, although the importance has been recognized for hyphal growth. transport of ergosterol to hyphal tips is thought to be important for th ... | 2015 | 26116213 |
| metabolites produced by the endophytic fungus aspergillus fumigatus from the stem of erythrophloeum fordii oliv. | a new diketopiperazine alkaloid named spirotryprostatin k (1), and five known alkaloids, spiro[5h,10h-dipyrrolo[1,2-a:1',2'-d]pyrazine-2(3h),2'-[2h]-indole]-3',5,10(1'h) trione (2), 6-methoxyspirotryprostatin b (3), pseurotin a (4), n-β-acetyltryptamine (5), and lumichrome (6) were isolated from the endophytic fungus aspergillus fumigatus. the structure and the absolute configuration of spirotryprostatin k were established by extensive spectroscopic analyses, acid hydrolysis and ecd calculations ... | 2015 | 26111169 |
| automated quantification of the phagocytosis of aspergillus fumigatus conidia by a novel image analysis algorithm. | studying the pathobiology of the fungus aspergillus fumigatus has gained a lot of attention in recent years. this is due to the fact that this fungus is a human pathogen that can cause severe diseases, like invasive pulmonary aspergillosis in immunocompromised patients. because alveolar macrophages belong to the first line of defense against the fungus, here, we conduct an image-based study on the host-pathogen interaction between murine alveolar macrophages and a. fumigatus. this is achieved by ... | 2015 | 26106370 |
| generation of broad-spectrum antifungal drug candidates from the natural product compound aureobasidin a. | the natural product aureobasidin a (aba) is a potent, well-tolerated antifungal agent with robust efficacy in animals. although native aba is active against a number of fungi, it has little activity against aspergillus fumigatus, an important human pathogen, and attempts to improve the activity against this organism by structural modifications have to date involved chemistries too complex for continued development. this report describes novel chemistry for the modification of aba. the key step i ... | 2015 | 26101567 |
| characterization and identification of the xylanolytic enzymes from aspergillus fumigatus z5. | plant biomass, the most abundant natural material on earth, represents a vast source of food and energy in nature. as the main component of plant biomass, xylan is a complex polysaccharide comprising a linear β(1,4)-linked backbone of xylosyl residues substituted by acetyl, arabinosyl, glucuronysyl and 4-o-methylglucuronycyl residues. | 2015 | 26100973 |
| transcription factor ads-4 regulates adaptive responses and resistance to antifungal azole stress. | azoles are commonly used as antifungal drugs or pesticides to control fungal infections in medicine and agriculture. fungi adapt to azole stress by rapidly activating the transcription of a number of genes, and transcriptional increases in some azole-responsive genes can elevate azole resistance. the regulatory mechanisms that control transcriptional responses to azole stress in filamentous fungi are not well understood. this study identified a bzip transcription factor, ads-4 (antifungal drug s ... | 2015 | 26100701 |
| antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification. | nine diketopiperazines were characterized from the culture of marine fungal isolate mr2012 which based on dna amplification and sequencing of the fungal internal transcribed spacer (its) region was identified as aspergillus fumigatus. the isolated fungal metabolites 4-12 were unambiguously identified as a series of simple and re-arranged diketopiperazines by analysis of spectroscopic data. t-butoxycarbonyl group (boc) derivatization was used to separate the intractable mixture of 4 and 5. when a ... | 2015 | 26099531 |
| sensitization pattern affects the asthma risk in finnish adult population. | there is a large global variation in the sensitization pattern and its association with allergic diseases. in temperate and tropical urban environments, mite monosensitization can be the predominant cause of allergic airway diseases, whereas in other environments, polysensitization is more typical. sensitization to mite allergens associates with asthma. however, it is suggested that mite sensitization might play a minor role in northern europe. the aim of the study was to analyze how sensitizati ... | 2015 | 26095518 |
| genotype-phenotype complexity of the tr46/y121f/t289a cyp51a azole resistance mechanism in aspergillus fumigatus. | the aspergillus fumigatus cyp51a gene tr46/y121f/t289a mutation is a new emerging resistance mechanism with high-level voriconazole (vor) resistance, and elevated mics to all other medical azoles. this is highly worrisome as vor is the primary drug for the treatment of many aspergillus diseases. the 46 base pair tandem repeat (tr46) is positioned at the same location of the cyp51a gene promoter region as has been described for other tandem repeats. the exact role of the tr46 in combination with ... | 2015 | 26092193 |
| correction: the ph-responsive pacc transcription factor of aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. | 2015 | 26086393 | |
| fungus induces the release of il-8 in human corneal epithelial cells, via dectin-1-mediated protein kinase c pathways. | to identify whether aspergillus fumigatus (a. fumigatus) hyphae antigens induced the release of interleukin-8 (il-8) in anti-fungal innate immunity of cultured human corneal epithelial cells (hcecs) and determine the involvement of intracellular signalling pathways. | 2015 | 26085988 |
| analytical comparison of in vitro-spiked human serum and plasma for pcr-based detection of aspergillus fumigatus dna: a study by the european aspergillus pcr initiative. | the use of serum or plasma for aspergillus pcr testing facilitates automated and standardized technology. recommendations for serum testing are available, and while serum and plasma are regularly considered interchangeable for use in fungal diagnostics, differences in galactomannan enzyme immunoassay (gm-eia) performance have been reported and are attributed to clot formation. therefore, it is important to assess plasma pcr testing to determine if previous recommendations for serum are applicabl ... | 2015 | 26085614 |
| first detection of aspergillus fumigatus azole-resistant strain due to cyp51a tr46/y121f/t289a in an azole-naive patient in spain. | we report the first isolation of a voriconazole-resistant aspergillus fumigatus strain harbouring the azole resistance mechanism tr46/y121f/t289a, recovered from an azole-naive patient in spain with chronic obstructive pulmonary disease. this new finding in spain suggests the spread of this resistance mechanism and reinforces the need for antifungal susceptibility surveillance. | 2015 | 26082842 |
| genome-wide transcriptomic analysis of a superior biomass-degrading strain of a. fumigatus revealed active lignocellulose-degrading genes. | various saprotrophic microorganisms, especially filamentous fungi, can efficiently degrade lignocellulose that is one of the most abundant natural materials on earth. it consists of complex carbohydrates and aromatic polymers found in the plant cell wall and thus in plant debris. aspergillus fumigatus z5 was isolated from compost heaps and showed highly efficient plant biomass-degradation capability. | 2015 | 26076650 |
| deciphering chemokine properties by a hybrid agent-based model of aspergillus fumigatus infection in human alveoli. | the ubiquitous airborne fungal pathogen aspergillus fumigatus is inhaled by humans every day. in the lung, it is able to quickly adapt to the humid environment and, if not removed within a time frame of 4-8 h, the pathogen may cause damage by germination and invasive growth. applying a to-scale agent-based model of human alveoli to simulate early a. fumigatus infection under physiological conditions, we recently demonstrated that alveolar macrophages require chemotactic cues to accomplish the ta ... | 2015 | 26074897 |
| epidemiological aspect and common bacterial and fungal isolates from suppurative corneal ulcer in mymensingh region. | this prospective study was done to find out the epidemiological factors of suppurative corneal ulcer and the common causative bacterial and fungal isolates from the, patients with suppurative corneal ulcer in secondary and tertiary level hospital at mymensingh region. a total 100 samples of corneal scrapings were collected purposively from clinically diagnosed suppurative corneal ulcer patients from march 18, 2012 to march 17, 2013. out of the total 100 samples, bacterial species were 29(29%) ca ... | 2015 | 26007250 |
| synthesis, in-vitro antibacterial, antifungal, and molecular modeling of potent anti-microbial agents with a combined pyrazole and thiophene pharmacophore. | ethyl 5-acetyl-4-methyl-2-(phenylamino)thiophene-3-carboxylate (2) and there derivatives 3a-c, 4, 6a-c and 9a-f were synthesized. the structure of compound 2 was deduced by 1h-nmr, 13c-nmr, ft-ir, ms, microanalysis, and single-crystal x-ray crystallography. the compound crystallized in the monoclinic system, with space group p21/c and cell coordinates a = 8.5752(16) å, b = 21.046(4) å, c = 8.2941(12) å, β = 101.131(6)°, v = 1468.7(4) å3, and z = 4. compounds 2, 3a-c, 4, 5a-c and 9a-f were subjec ... | 2015 | 26007175 |
| prevalence and mechanism of triazole resistance in aspergillus fumigatus in a referral chest hospital in delhi, india and an update of the situation in asia. | aspergillus fumigatus causes varied clinical syndromes ranging from colonization to deep infections. the mainstay of therapy of aspergillus diseases is triazoles but several studies globally highlighted variable prevalence of triazole resistance, which hampers the management of aspergillosis. we studied the prevalence of resistance in clinical a. fumigatus isolates during 4 years in a referral chest hospital in delhi, india and reviewed the scenario in asia and the middle east. aspergillus speci ... | 2015 | 26005442 |
| strain differences in the immune mechanisms of resistance of immunocompetent rats to pulmonary aspergillosis. | although the relevance of genetically-based variations in susceptibility to pulmonary aspergillosis was shown in immunocompromised mice and is indicated in humans, there is virtually no information concerning variations in antifungal immune responses in resistant individuals. we have shown recently the relevance of proinflammatory cytokine (interferon-γ/ifn-γ and interleukin-17/il-17) responses in resistance to sublethal aspergillus fumigatus infection of non-suppressed dark agouti (da) rats (st ... | 2015 | 26004347 |
| the clinical presentations of pulmonary aspergillosis in children with cystic fibrosis - preliminary report. | pulmonary aspergillosis is a very serious complication in cystic fibrosis (cf) patients due to the great variety of its clinical presentations and the fact that it worsens the prognosis. we can distinguish the following: aspergillus colonization (ac), aspergillus infection (ai) and allergic bronchopulmonary aspergillosis (abpa). aspergillus colonization (ac) is defined as isolation of aspergillus spp. from 50% ormore sputum samples over six months to one year without observing deterioration in l ... | 2015 | 26003072 |
| a facile synthesis of novel miconazole analogues and the evaluation of their antifungal activity. | four novel miconazole analogues (8-11) were synthetized and evaluated for activity against four filamentous fungi (mucor hiemalis, aspergillus fumigatus, trichosporon cutaneum, and rhizopus oryzae) and eight species of candida as yeast specimens. compounds 9 and 10 showed very good activity when evaluated in yeast (mic 0.112 and 0.163 μg/ml) compared to the reference compound, itraconazole (mic 0.067 μg/ml). the best antifungal activity in filamentous strains was shown by compound 9. hence compo ... | 2015 | 25989345 |
| prospective multicenter international surveillance of azole resistance in aspergillus fumigatus. | to investigate azole resistance in clinical aspergillus isolates, we conducted prospective multicenter international surveillance. a total of 3,788 aspergillus isolates were screened in 22 centers from 19 countries. azole-resistant a. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles. | 2015 | 25988348 |
| nationwide surveillance of azole resistance in aspergillus diseases. | aspergillus disease affects a broad patient population, from patients with asthma to immunocompromised patients. azole resistance has been increasingly reported in both clinical and environmental aspergillus strains. the prevalence and clinical impact of azole resistance in different patient populations are currently unclear. this 1-year prospective multicenter cohort study aimed to provide detailed epidemiological data on aspergillus resistance among patients with aspergillus disease in belgium ... | 2015 | 25987612 |
| cyp2c19*17 genetic polymorphism--an uncommon cause of voriconazole treatment failure. | we describe an immunosuppressed, 48-year-old male, allogeneic hematopoietic stem cell transplant recipient with severe graft-versus-host disease who developed invasive pulmonary aspergillus fumigatus infection 6 months after transplant. his lack of response to voriconazole and undetectable serum trough levels of the drug led us to establish that he had the uncommon cytochrome p450, cyp2c19*17 allele, which leads to a rapid metabolism of voriconazole but not of the other azole antifungals. we dis ... | 2015 | 25986028 |
| bio-harvesting and pyrolysis of the microalgae botryococcus braunii. | the microalgae botryococcus braunii is widely recognized as a potentially important biofuel-feedstock whose commercial exploitation is limited by difficulties with its cultivation and harvesting. in this study, two b. braunii strains, kossou-4 and overjuyo-3 were successfully cultured at a 500 l-scale for 60-days. harvesting by bio-flocculation with aspergillus fumigatus at an optimum ratio of 1:40 of fungus to microalgal culture resulted in up to 98% recovery of biomass in the two strains. ulti ... | 2015 | 25983230 |
| gliotoxin production by aspergillus fumigatus strains from animal environment. micro-analytical sample treatment combined with a lc-ms/ms method for gliotoxin determination. | in this study, gliotoxin production by aspergillus fumigatus strains from animal environment is studied. moreover, a rapid, easy and environment-friendly micro-analytical sample treatment procedure coupled with lc-ms/ms was applied for the determination of gliotoxin from a. fumigatus cultures. the ability of gliotoxin production by 143 strains was assayed in yeast extract sucrose agar, and 1 ml of chloroform was used for toxin extraction without further clean-up. mean recoveries at two spiking l ... | 2015 | 25982450 |
| tnf-related apoptosis-inducing ligand (trail) regulates midline-1, thymic stromal lymphopoietin, inflammation, and remodeling in experimental eosinophilic esophagitis. | eosinophilic esophagitis (eoe) is an inflammatory disorder of the esophagus defined by eosinophil infiltration and tissue remodeling with resulting symptoms of esophageal dysfunction. tnf-related apoptosis-inducing ligand (trail) promotes inflammation through upregulation of the e3 ubiquitin-ligase midline-1 (mid1), which binds to and deactivates the catalytic subunit of protein phosphatase 2ac, resulting in increased nuclear factor κb activation. | 2015 | 25981737 |
| prior in vitro exposure to voriconazole confers resistance to amphotericin b in aspergillus fumigatus biofilms. | triazoles are the mainstay of treatment for aspergillosis, although resistance to these antifungal agents may be associated with treatment failure. refractory infections often necessitate a switch to other antifungal agents, including amphotericin b (amb), although these infections may not resolve. the aim of this study was to investigate the effect of prior azole exposure on amb sensitivity in aspergillus fumigatus biofilms. it was hypothesised that sequential antifungal therapy has the potenti ... | 2015 | 25979638 |
| evolution of fungal populations in corn silage conserved under polyethylene or biodegradable films. | to identify cultivable filamentous fungi before ensiling, after silage conservation, in farm-silos covered with two different plastic films (polyethylene (pe) vs biodegradable (mb)), as well as after aerobic exposure of whole-crop corn silage. | 2015 | 25976243 |
| photodynamic activity of nanostructured fabrics grafted with xanthene and thiazine dyes against opportunistic fungi. | fungi are an important class of human pathogens for which considerable research has gone into defeating them. the photodynamic effects of rose bengal (rb), phloxine b (pb), azure a (aa), and toluidine blue o (tbo) dyes to inhibit aspergillus fumigatus, aspergillus niger, trichoderma viride, penicillium funiculosum, and chaetomium globosum were investigated grafted to nano- and micro-structured fabrics. three antifungal tests conducted: broth microdilution test of free dyes, zone of inhibition an ... | 2015 | 25972050 |
| activation of vitamin d regulates response of human bronchial epithelial cells to aspergillus fumigatus in an autocrine fashion. | aspergillus fumigatus (a. fumigatus) is one of the most common fungi to cause diseases in humans. recent evidence has demonstrated that airway epithelial cells play an important role in combating a. fumigatus through inflammatory responses. human airway epithelial cells have been proven to synthesize the active vitamin d, which plays a key role in regulating inflammation. the present study was conducted to investigate the impact of a. fumigatus infection on the activation of vitamin d and the ro ... | 2015 | 25960612 |
| bronchial myeloid sarcoma with concurrent aspergillus fumigatus infection in a patient presenting with hemoptysis. | myeloid sarcoma (ms) is an extramedullary myeloid neoplasm characterized by proliferation of myeloblasts which can occur in any organ or site. bronchial and pulmonary involvement, however, is uncommon. we describe a case of bronchial ms in an 81-year-old female with a history of high-grade myelodysplastic syndrome; she was started on treatment few months before, and she presented with fever, cough and profuse hemoptysis. she was found to be pancytopenic with bilateral airspace consolidations, mo ... | 2015 | 25959740 |
| co-recognition of β-glucan and chitin and programming of adaptive immunity to aspergillus fumigatus. | the prevalence of fungal infections has increased concurrently with increases in immune suppressive therapies and susceptible individuals. opportunistic fungal pathogens such as aspergillus fumigatus may exhibit invasive growth and dissemination resulting in a high mortality rate. herein, we discuss how immune sensing of germination directs innate immune responses and programs adaptive responses that could promote or impair immune protection during periods of heightened susceptibility. in infect ... | 2015 | 25954267 |
| assessment of microbial contamination within working environments of different types of composting plants. | the objective of the study was to determine the degree of microbiological contamination, type of microflora, bioaerosol particle size distribution, and concentration of endotoxins in dust in different types of composting plants. in addition, this study provides a list of indicator microorganisms that pose a biological threat in composting facilities, based on their prevalence within the workplace, source of isolation, and health hazards. we undertook microbiological analysis of the air, work sur ... | 2015 | 25947216 |
| an adenoviral vector encoding full-length dectin-1 promotes aspergillus-induced innate immune response in macrophages. | the incidence of invasive pulmonary aspergillosis (ipa) has increased significantly over the last two decades. alveolar macrophages (ams) represent the first line of pulmonary host response to aspergillus conidia. recognition of conidia by ams involves dectin-1 (clec7a), which is a conserved structure to combine β-glucans. the deficiency of dectin-1 results in impaired fungal killing and uncontrolled growth of aspergillus fumigatus. thus, we hypothesized that high expression of dectin-1 would en ... | 2015 | 25944256 |
| systematic global analysis of genes encoding protein phosphatases in aspergillus fumigatus. | aspergillus fumigatus is a fungal pathogen that causes several invasive and noninvasive diseases named aspergillosis. this disease is generally regarded as multifactorial, considering that several pathogenicity determinants are present during the establishment of this illness. it is necessary to obtain an increased knowledge of how, and which, a. fumigatus signal transduction pathways are engaged in the regulation of these processes. protein phosphatases are essential to several signal transduct ... | 2015 | 25943523 |
| glucocorticosteroids do not impact directly growth rate and biomass of rhizopus arrhizus (syn. r. oryzae) in vitro. | glucocorticoid (gc) use is a common risk factor for invasive fungal infections. this is attributed to the complex dysregulation of immunity caused by gcs. however, studies have demonstrated increased growth with gc exposure for some molds, such as aspergillus fumigatus and exserohilum rostratum. no such data exist for mucorales. therefore, we investigated the influence of gc exposure on the growth of rhizopus arrhizus (syn. r. oryzae) in different culture media and in different atmospheres. we m ... | 2015 | 25942104 |
| environmental isolates of azole-resistant aspergillus fumigatus in germany. | azole antifungal drug resistance in aspergillus fumigatus is an emerging problem in several parts of the world. here we investigated the distribution of such strains in soils from germany. at a general positivity rate of 12%, most prevalently, we found strains with the tr34/l98h and tr46/y121f/t289a alleles, dispersed along a corridor across northern germany. comparison of the distributions of resistance alleles and genotypes between environment and clinical samples suggests the presence of loca ... | 2015 | 25941229 |
| trem-1 expression in rat corneal epithelium with aspergillus fumigatus infection. | to investigate the expression of triggering receptor expressed on myeloid cells-1 (trem-1) in the aberrant inflammation within the corneal epithelium at early period of fungal infection. | 2015 | 25938031 |
| the innate immune response to aspergillus fumigatus at the alveolar surface. | aspergillus fumigatus is an ubiquitous, saprophytic mould that forms and releases airborne conidia which are inhaled by humans on a daily basis. when the immune system is compromised (e.g. immunosuppressive therapy prior to organ transplantation) or there is pre-existing pulmonary malfunction (e.g. asthma, cystic fibrosis, tb lesions), a. fumigatus exploits weaknesses in the host defenses which can result in the development of saphrophytic, allergic or invasive aspergillosis. if not effectively ... | 2015 | 25934117 |
| the aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence. | aspergillus fumigatus is the most important airborne fungal pathogen, causing severe infections with invasive growth in immunocompromised patients. the fungal cell wall (cw) prevents the cell from lysing and protects the fungus against environmental stress conditions. because it is absent in humans and because of its essentiality, the fungal cw is a promising target for antifungal drugs. nowadays, compounds acting on the cw, i.e., echinocandin derivatives, are used to treat a. fumigatus infectio ... | 2015 | 25932027 |
| cxcr4+ granulocytes reflect fungal cystic fibrosis lung disease. | cystic fibrosis airways are frequently colonised with fungi. however, the interaction of these fungi with immune cells and the clinical relevance in cystic fibrosis lung disease are incompletely understood.we characterised granulocytes in airway fluids and peripheral blood from cystic fibrosis patients with and without fungal colonisation, non-cystic fibrosis disease controls and healthy control subjects cross-sectionally and longitudinally and correlated these findings with lung function parame ... | 2015 | 25929952 |
| epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes. | invasive aspergillosis (ia) is a fungal infection that particularly affects immunocompromised hosts. recently, several studies have indicated a high incidence of ia in intensive care unit (icu) patients. however, few data are available on the epidemiology and outcome of patients with ia in this setting. | 2015 | 25928694 |
| regulation of b-cell-activating factor expression on the basophil membrane of allergic patients. | to investigate the modulation of b-cell-activating factor (baff) expression on the basophil membrane of allergic patients. baff is an important regulator of b-cell activation, proliferation and immunoglobulin production, which may play a role in respiratory allergic diseases in promoting the production of ige by b cells. | 2015 | 25924578 |
| first description of azole-resistant aspergillus fumigatus due to tr46/y121f/t289a mutation in france. | azole resistance in aspergillus fumigatus is an emerging public health concern. recently, a novel fungicide-driven mutation in the cyp51a gene and its promoter, tr46/y121f/t289a, leading to high-level resistance to voriconazole has been identified in the netherlands, belgium, germany, denmark, tanzania, and india in both clinical and environmental samples. here we report the first description of a. fumigatus carrying this mutation in france, in a cystic fibrosis patient, underlining the need for ... | 2015 | 25918139 |
| azole-resistant aspergillosis. | azole-resistance in aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. the main molecular mechanism of azole resistance in a. fumigatus is explained by mutations in the cyp51a-gene. the environmental route of resistance development is particularly worrying and may ... | 2015 | 25917808 |
| the aspergillus fumigatus sita phosphatase homologue is important for adhesion, cell wall integrity, biofilm formation, and virulence. | aspergillus fumigatus is an opportunistic pathogenic fungus able to infect immunocompromised patients, eventually causing disseminated infections that are difficult to control and lead to high mortality rates. it is important to understand how the signaling pathways that regulate these factors involved in virulence are orchestrated. protein phosphatases are central to numerous signal transduction pathways. here, we characterize the a. fumigatus protein phosphatase 2a sita, the saccharomyces cere ... | 2015 | 25911225 |
| [indoor fungal exposure: what impact on clinical and biological status regarding aspergillus during cystic fibrosis]. | the sources of exposure during diseases due to aspergillus fungi in cystic fibrosis patients are still poorly explored. we assessed home fungal exposure in patients suffering from cystic fibrosis and analysed its impact on the presence of aspergillus biological markers, the colonisation of airways, as well as the sensitization and aspergillus serology. between march 2012 and august 2012, 34 patients benefited from a visit performed by a home environment medical adviser including sampling for myc ... | 2015 | 25910711 |
| genetic analysis using an isogenic mating pair of aspergillus fumigatus identifies azole resistance genes and lack of mat locus's role in virulence. | invasive aspergillosis (ia) due to aspergillus fumigatus is a major cause of mortality in immunocompromised patients. the discovery of highly fertile strains of a. fumigatus opened the possibility to merge classical and contemporary genetics to address key questions about this pathogen. the merger involves sexual recombination, selection of desired traits, and genomics to identify any associated loci. we constructed a highly fertile isogenic pair of a. fumigatus strains with opposite mating type ... | 2015 | 25909486 |
| iron acquisition and oxidative stress response in aspergillus fumigatus. | aspergillus fumigatus is a ubiquitous airborne fungal pathogen that presents a life-threatening health risk to individuals with weakened immune systems. a. fumigatus pathogenicity depends on its ability to acquire iron from the host and to resist host-generated oxidative stress. gaining a deeper understanding of the molecular mechanisms governing a. fumigatus iron acquisition and oxidative stress response may ultimately help to improve the diagnosis and treatment of invasive aspergillus infectio ... | 2015 | 25908096 |
| amca-a putative mitochondrial ornithine transporter supporting fungal siderophore biosynthesis. | iron is an essential nutrient required for a wide range of cellular processes. the opportunistic fungal pathogen aspergillus fumigatus employs low-molecular mass iron-specific chelators, termed siderophores, for uptake, storage and intracellular iron distribution, which play a crucial role in the pathogenicity of this fungus. siderophore biosynthesis (sb) depends on coordination with the supply of its precursor ornithine, produced mitochondrially from glutamate or cytosolically via hydrolysis of ... | 2015 | 25904899 |
| high-level pan-azole-resistant aspergillosis. | high-level pan-azole-resistant aspergillus fumigatus was recovered from four patients with chronic lung disease. in one patient, the development of progressive resistance followed long-term azole therapy and switching between antifungal azoles. the high-level pan-azole-resistant phenotypes were not associated with a specific cyp51a gene mutation. new strategies that avoid the development of progressive azole resistance are needed. | 2015 | 25903576 |
| analytical and clinical evaluation of the pathonostics aspergenius assay for detection of invasive aspergillosis and resistance to azole antifungal drugs during testing of serum samples. | the commercially developed pathonostics aspergenius species assay is a multiplex real-time pcr capable of detecting aspergillosis and genetic markers associated with azole resistance. the assay is validated for testing bronchoalveolar lavage fluids, replacing the requirement for culture and benefiting patient management. application of this assay to less invasive, easily obtainable samples (e.g., serum) might be advantageous. the aim of this study was to determine the analytical and clinical per ... | 2015 | 25903571 |
| synthesis, biological evaluation and 2d-qsar study of halophenyl bis-hydrazones as antimicrobial and antitubercular agents. | in continuation of our endeavor towards the development of potent and effective antimicrobial agents, three series of halophenyl bis-hydrazones (14a-n, 16a-d, 17a and 17b) were synthesized and evaluated for their potential antibacterial, antifungal and antimycobacterial activities. these efforts led to the identification of five molecules 14c, 14g, 16b, 17a and 17b (mic range from 0.12 to 7.81 μg/ml) with broad antimicrobial activity against mycobacterium tuberculosis; aspergillus fumigates; gra ... | 2015 | 25903147 |
| antifungal susceptibilities of candida, cryptococcus neoformans and aspergillus fumigatus from the asia and western pacific region: data from the sentry antifungal surveillance program (2010-2012). | the sentry antifungal surveillance program monitors global susceptibility rates of newer and established antifungal agents. we report the in vitro activity of seven antifungal agents against 496 contemporary clinical isolates of yeasts and molds. the isolates were obtained from 20 laboratories in the asia-western pacific (apac) region during 2010 through 2012. anidulafungin, caspofungin, micafungin, fluconazole, itraconazole, posaconazole and voriconazole were susceptibility tested using clsi me ... | 2015 | 25899126 |
| multiple cyp51a-based mechanisms identified in azole-resistant isolates of aspergillus fumigatus from china. | seventy-two a. fumigatus clinical isolates from china were investigated for azole resistance based on mutations of cyp51a. we identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the tr34/l98h/s297t/f495i mutation, while one carries only the tr34/l98h mutation. to our knowledge, the latter has not been found previously in china. the fourth multiazole-resistant isolate (with only moderate itraconazole resistance) carrie ... | 2015 | 25896700 |
| optimization of polyene-azole combination therapy against aspergillosis using an in vitro pharmacokinetic-pharmacodynamic model. | although amphotericin b-azole combination therapy has traditionally been questioned due to potential antagonistic interactions, it is often used successfully to treat refractory invasive aspergillosis. so far, pharmacodynamic (pd) interactions have been assessed with conventional in vitro tests, which do not mimic human serum concentrations and animal models using limited doses. we therefore simulated the human serum concentration profiles of amphotericin b and voriconazole in an in vitro dialys ... | 2015 | 25896699 |
| invasive pulmonary aspergillosis in heart transplant recipients. | invasive pulmonary aspergillosis is the most common invasive mycosis in heart transplant recipients. early clinical recognition of this complication is difficult and laboratory data is not specific. our aim was to study the characteristics of invasive pulmonary aspergillosis infections in heart transplant recipients. | 2015 | 25894189 |
| role of bronchoalveolar lavage in diagnosis of fungal infections in liver transplant recipients. | pulmonary fungal infections remain the most important cause of morbidity and mortality in liver transplant recipients. fast and accurate causative diagnoses are essential for a good outcome. bronchoscopy with bronchoalveolar lavage frequently is performed to diagnose pulmonary infections in immunocompromised patients. the aim of this study was to evaluate the diagnostic use of bronchoalveolar lavage in liver transplant recipients with pulmonary infections. | 2015 | 25894185 |
| the gβ-like protein cpcb is required for hyphal growth, conidiophore morphology and pathogenicity in aspergillus fumigatus. | cpcb (cross pathway control b) encodes a yeast cpc2 and mammalian rack1 (receptor for activated protein kinase c) ortholog, which is a wd repeat protein with functional homology to the β subunit of heterotrimeric g proteins in aspergillus fumigatus. previous study has reported that cpcb governs growth and development in both a. fumigatus and aspergillus nidulans. however, little is known about the functional identities of cpcb orthologs and their relationships with g protein complexes. in this s ... | 2015 | 25892048 |
| th17 cytokine deficiency in patients with aspergillus skull base osteomyelitis. | fungal skull base osteomyelitis (sbo) is a severe complication of otitis externa or sinonasal infection, and is mainly caused by aspergillus species. here we investigate innate and adaptive immune responses in patients with aspergillus sbo to identify defects in the immune response that could explain the susceptibility to this devastating disease. | 2015 | 25888308 |
| multi-triazole-resistant aspergillus fumigatus infections in australia. | the emergence of triazole resistance, including multi-triazole-resistant aspergillus fumigatus is being reported around the world, but there has been little evidence of this problem to date in australia. here we describe a retrospective search of antifungal susceptibility results of all australian clinical a. fumigatus isolates referred to the national mycology reference centre, adelaide, australia between 2000 and 2013, yielding 13 isolates with elevated minimum inhibitory concentrations to itr ... | 2015 | 25885568 |
| experimental study on cryotherapy for fungal corneal ulcer. | fungal corneal ulcer is one of the major causes of visual impairment worldwide. treatment of fungal corneal ulcer mainly depends on anti-fungal agents. in the current study, we developed an integrated combination therapy of cryotherapy and anti-fungal agents to facilitate effective treatment of fungal corneal ulcer. | 2015 | 25880872 |
| antibiosis interaction of staphylococccus aureus on aspergillus fumigatus assessed in vitro by mixed biofilm formation. | microorganisms of different species interact in several ecological niches, even causing infection. during the infectious process, a biofilm of single or multispecies can develop. aspergillus fumigatus and staphyloccocus aureus are etiologic agents that can cause infectious keratitis. we analyzed in vitro single a. fumigatus and s. aureus, and mixed a. fumigatus-s. aureus biofilms. both isolates were from patients with infectious keratitis. structure of the biofilms was analyzed through microscop ... | 2015 | 25880740 |
| microbial diversity in bioaerosol samples causing odts compared to reference bioaerosol samples as measured using illumina sequencing and maldi-tof. | the importance of the microbial diversity of bioaerosols in relation to occupational exposure and work related health symptoms is not known. the aim of this paper is to gain knowledge on the bacterial and fungal communities in dust causing organic dust toxic syndrome (odts) and in reference dust not causing odts. bacterial and fungal communities were described in personal exposure samples from grass seed workers developing odts, in dust generated from grass seeds causing odts and in dust generat ... | 2015 | 25880607 |
| genetic manipulation of the pneumocandin biosynthetic pathway for generation of analogues and evaluation of their antifungal activity. | pneumocandins are lipohexapeptides of the echinocandin family that potently interrupt fungal cell wall biogenesis by noncompetitive inhibition of 1,3-β-glucan synthase. the pneumocandin biosynthetic gene cluster was previously elucidated by whole genome sequencing. in addition to the core nonribosomal peptide synthetase and polyketide synthase (glnrps4 and glpks4), the pneumocandin biosynthetic cluster includes two p450-type hemeprotein monooxygenase genes (glp450-1 and glp450-2) and four nonhem ... | 2015 | 25879325 |
| a fungal protease allergen provokes airway hyper-responsiveness in asthma. | asthma, a common disorder that affects >250 million people worldwide, is defined by exaggerated bronchoconstriction to inflammatory mediators including acetylcholine (ach), bradykinin and histamine-also termed airway hyper-responsiveness. nearly 10% of people with asthma have severe, treatment-resistant disease, which is frequently associated with immunoglobulin-e sensitization to ubiquitous fungi, typically aspergillus fumigatus (af). here we show that a major af allergen, asp f13, which is a s ... | 2015 | 25865874 |
| does use of the polyene natamycin as a food preservative jeopardise the clinical efficacy of amphotericin b? a word of concern. | natamycin is a poorly soluble, polyene macrolide antifungal agent used in the food industry for the surface treatment of cheese and sausages. this use is not of safety concern. however, highly soluble natamycin-cyclodextrin inclusion complexes have been developed for the protection of beverages. this practice leads to high drug exposures exceeding the safety level. apart from the definition of an acceptable daily dietary exposure to natamycin, its effect on the faecal flora as a reservoir for re ... | 2015 | 25862309 |
| allergic bronchopulmonary aspergillosis presenting as recurrent mass-like consolidation. | allergic bronchopulmonary aspergillosis (abpa) is a hypersensitive disease showing various radiographic and clinical manifestations. its clinical course has not been fully understood. here i describe a case of a 23-year-old immunocompetent man with frequently relapsing abpa. he was asthmatic. he visited our hospital because of a chronic cough. laboratory examination showed eosinophilia with increased total and aspergillus-specific ige as well as positive skin reaction to aspergillus fumigatus. r ... | 2015 | 25861349 |
| biodegradation of pesticides using fungi species found in the aquatic environment. | relatively limited attention has been given to the presence of fungi in the aquatic environment compared to their occurrence in other matrices. taking advantage and recognizing the biodegradable capabilities of fungi is important, since these organisms may produce many potent enzymes capable of degrading toxic pollutants. therefore, the aim of this study was to evaluate the potential ability of some species of filamentous fungi that occur in the aquatic environment to degrade pesticides in untre ... | 2015 | 25860553 |