Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| dissecting the regulation of ebv's bart mirnas in carcinomas. | epstein-barr virus (ebv) encodes multiple mirnas known to contribute to its pathogenicity. previous studies have found that the levels of some ebv mirnas are 10-100 fold higher in biopsies and in tumor xenografts than in cells grown in culture. we have asked if these increased levels reflect transcriptional enhancement resulting from the tumor microenvironment, selection for increased levels of the ebv genome, or both. we measured the levels of bart mirnas and their dna templates in tumor xenogr ... | 2017 | 28259048 |
| analysis of bzlf1 mrna detection in saliva as a marker for active replication of epstein-barr virus. | monitoring replicative epstein-barr virus (ebv) infection still remains a challenge in modern laboratory routine. the immediate-early protein bzlf1 mediates the switch between latent and replicate forms of ebv infection. the aim of this study was to analyze the feasibility of bzlf1 mrna detection in saliva as a marker for active replication of the virus. various specimens (saliva, plasma, pbmc) from 17 patients with ebv-induced infectious mononucleosis (im) and 4 control patients were examined f ... | 2017 | 28257801 |
| computed tomography findings in epstein-barr virus (ebv)-positive diffuse large b-cell lymphoma (dlbcl) of the elderly: comparison with ebv-negative dlbcl. | this study aimed to compare ct findings in patients with epstein-barr virus positive (ebv+) diffuse large b-cell lymphoma (dlbcl) of the elderly with ct findings in patients with epstein-barr virus negative (ebv-) dlbcl. | 2017 | 28256900 |
| frequent downregulation of bach2 expression in epstein-barr virus-positive diffuse large b-cell lymphoma. | diffuse large b-cell lymphoma (dlbcl) is the most common b-cell lymphoma subtypes, and the epstein-barr virus (ebv)-positive subtype of dlbcl is known to exhibit a more aggressive clinical behavior than the ebv-negative one. btb and cnc homology 2 (bach2) has been highlighted as a tumor suppressor in hematopoietic malignancies; however, the role of bach2 in ebv-positive dlbcl is unclear. in the present study, bach2 expression and its significance were studied in 23 ebv-positive and 43 ebv-negati ... | 2017 | 28256087 |
| the identification of up-regulated ebv-mir-bhrf1-2-5p targeting malt1 and ebv-mir-bhrf1-3 in the circulation of patients with multiple sclerosis. | epstein-barr virus (ebv) is a well-documented aetiological factor for multiple sclerosis (ms). ebv encodes at least 44 micrornas (mirnas) that are readily detectable in the circulation of human. previous studies have demonstrated that ebv-encoded mirnas regulate host immune response and may serve as biomarkers for ebv-associated diseases. however, the roles of ebv mirnas in ms are still unknown. to fill the gap, we conducted a comprehensive profiling of 44 mature ebv mirnas in 30 relapsing-remit ... | 2017 | 28253538 |
| the prevalence of viral agents in esophageal adenocarcinoma and barrett's esophagus: a systematic review. | human papilloma virus (hpv), which may reach the esophagus through orogenital transmission, has been postulated to be associated with esophageal adenocarcinoma (eac). a systematic review of the literature investigating the prevalence of infectious agents in eac and barrett's esophagus (be) was carried out. | 2017 | 28252462 |
| prolonged fever in an 8-year-old boy post-epstein-barr virus infection. | 2017 | 28251742 | |
| prolonged fever in an 8-year-old boy post-epstein-barr virus infection. | 2017 | 28251741 | |
| primary pulmonary lymphoepithelioma-like carcinoma on fdg pet/ct. | a 69-year-old male smoker was referred to (18)f-fluorodeoxyglucose (fdg) positron emission tomography-computed tomography (pet/ct) with the indication of a suspicious solitary pulmonary nodule. fdg pet/ct determined a 2.5 × 2-cm soft-tissue lesion (suvmax, 16.2) with spiculated margins in the hilum of the right lung. a 1-cm diameter lymphadenopathy on the right hilum with an suvmax of 3.2 was also determined. transbronchial biopsy of the right hilar lymphadenopathy did not reveal any malignant f ... | 2017 | 28250863 |
| plasmablastic lymphoma versus plasmablastic myeloma: an ongoing diagnostic dilemma. | to determine the utility of clinical, morphological and phenotypical features in the differential diagnosis of plasmablastic lymphoma and myeloma with plasmablastic features. | 2017 | 28249941 |
| chloroquine triggers epstein-barr virus replication through phosphorylation of kap1/trim28 in burkitt lymphoma cells. | trials to reintroduce chloroquine into regions of africa where p. falciparum has regained susceptibility to chloroquine are underway. however, there are long-standing concerns about whether chloroquine increases lytic-replication of epstein-barr virus (ebv), thereby contributing to the development of endemic burkitt lymphoma. we report that chloroquine indeed drives ebv replication by linking the dna repair machinery to chromatin remodeling-mediated transcriptional repression. specifically, chlo ... | 2017 | 28249048 |
| plasmablastic lymphoma: review of 60 chinese cases and prognosis analysis. | plasmablastic lymphoma (pbl) is a b-cell malignancy associated with human immunodeficiency virus (hiv). pbl could also influence the hiv-negative patients. the study aimed to identify prognostic factors for survival among chinese pbl patients. | 2017 | 28248855 |
| kshv-associated and ebv-associated germinotropic lymphoproliferative disorder: new findings and review of the literature. | we report 2 cases of kaposi sarcoma-associated herpesvirus (kshv)-and epstein-barr virus (ebv) associated germinotropic lymphoproliferative disorder. both cases arose in patients from regions endemic for kshv, cape verde, and the democratic republic of the congo, presenting as localized lymphadenopathy. the affected lymph nodes showed colonization of the follicles by clusters of large atypical plasmablasts, but also showed regressive changes with vascular proliferation and interfollicular plasma ... | 2017 | 28248818 |
| hydroa vacciniforme-like t-cell lymphoma: a further brazilian case. | hydroa vacciniforme (hv)-like lymphoma is a rare, usually fatal epstein-barr virus-driven lymphoproliferative disease affecting children from asia, mexico, and south america. cutaneous manifestations imitate hv, a benign photodermatosis in which systemic symptoms are not observed, and spontaneous regression occurs later in adolescence or young adulthood. we report a case of hv-like lymphoma in a 12-year-old girl, descendent from an ancient amazon indigenous tribe that, as far as we know, represe ... | 2017 | 28248720 |
| update from the 4th edition of the world health organization classification of head and neck tumours: what is new in the 2017 who blue book for tumors and tumor-like lesions of the neck and lymph nodes. | the world health organization (who) 2017 classification of head and neck tumors ("blue book") will now include a new chapter on tumors and tumor-like lesions of the neck and lymph nodes, which was not included in the previous edition. tumors and tumor-like lesions, including a variety of cysts and metastases, can arise in any component in the neck, including soft tissue, lymph nodes, and developmental remnants. the pathology and clinical features of metastatic carcinoma of unknown primary in the ... | 2017 | 28247228 |
| epstein-barr virus lytic infection promotes activation of toll-like receptor 8 innate immune response in systemic sclerosis monocytes. | monocytes/macrophages are activated in several autoimmune diseases, including systemic sclerosis (scleroderma; ssc), with increased expression of interferon (ifn)-regulatory genes and inflammatory cytokines, suggesting dysregulation of the innate immune response in autoimmunity. in this study, we investigated whether the lytic form of epstein-barr virus (ebv) infection (infectious ebv) is present in scleroderma monocytes and contributes to their activation in ssc. | 2017 | 28245863 |
| analysis of the cross-talk of epstein-barr virus-infected b cells with t cells in the marmoset. | despite the well-known association of epstein-barr virus (ebv), a lymphocryptovirus (lcv), with multiple sclerosis, a clear pathogenic role for disease progression has not been established. the translationally relevant experimental autoimmune encephalomyelitis (eae) model in marmoset monkeys revealed that lcv-infected b cells have a central pathogenic role in the activation of t cells that drive eae progression. we hypothesized that lcv-infected b cells induce t-cell functions relevant for eae p ... | 2017 | 28243437 |
| the epstein-barr virus-encoded mir-bart22 targets map3k5 to promote host cell proliferative and invasive abilities in nasopharyngeal carcinoma. | mir-bart22, a new discovered epstein-barr virus (ebv) mirna, is abundant in nasopharyngeal carcinoma (npc). it has been reported that mir-bart22 promoted the tumor development by down-modulating ebv lmp2 expression to evade the host immune response. but its cell target genes have still been obscure. we have reported an inverse correlation between the bart-22 and map3k5 protein expression in npc tissues and npc cell lines. meanwhile, map3k5 protein expression level was significantly decreased in ... | 2017 | 28243335 |
| neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium. | bipolar disorder (bd) is a progressive psychiatric disorder with more than 3% prevalence worldwide. affected individuals experience recurrent episodes of depression and mania, disrupting normal life and increasing the risk of suicide greatly. the complexity and genetic heterogeneity of psychiatric disorders have challenged the development of animal and cellular models. we recently reported that hippocampal dentate gyrus (dg) neurons differentiated from induced pluripotent stem cell (ipsc)-derive ... | 2017 | 28242870 |
| targeting the programmed death-1 pathway in lymphoid neoplasms. | programmed death-1 (pd-1) is a co-inhibitory molecule and is seen in cd4+ and cd8+ t cells. upon binding to its ligands, programmed death ligand-1 (pd-l1) and -2 (pd-l2), pd-1 negatively regulates interleukin 2 (il-2) production and t cell proliferation. activated effector t-cells, which kill cancer cells, can be affected by pd-1 signaling in some lymphoid neoplasm that express pd-l1 or pd-l2. pd-l1 expression in tumor cells can be induced by extrinsic signal (i.e. interferon gamma) or intrinsic ... | 2017 | 28242522 |
| anaemia in hospitalised preschool children from a rural area in mozambique: a case control study in search for aetiological agents. | young children bear the world's highest prevalence of anaemia, the majority of which is of multifactorial aetiology, which in turn hampers its successful prevention. even moderate degrees of anaemia are associated with increased mortality and morbidity. despite this evidence, there is a lack of effective preventive programs and absence of consensus in the safety of iron supplementation in malaria areas, which reflects the poor understanding of the contribution of different aetiologies to anaemia ... | 2017 | 28241813 |
| pulmonary nodules in a kidney transplant recipient. | 2017 | 28240826 | |
| oncogenic s1p signalling in ebv-associated nasopharyngeal carcinoma activates akt and promotes cell migration through s1p receptor 3. | undifferentiated nasopharyngeal carcinoma (npc) is a cancer with high metastatic potential that is consistently associated with epstein-barr virus (ebv) infection. in this study, we have investigated the functional contribution of sphingosine-1-phosphate (s1p) signalling to the pathogenesis of npc. we show that ebv infection or ectopic expression of the ebv-encoded latent genes (ebna1, lmp1, and lmp2a) can up-regulate sphingosine kinase 1 (sphk1), the key enzyme that produces s1p, in npc cell li ... | 2017 | 28240350 |
| hla-dq β1 alleles associated with epstein-barr virus (ebv) infectivity and ebv gp42 binding to cells. | epstein-barr virus (ebv) infects b cells and ~95% of adults are infected. ebv glycoprotein gp42 is essential for entry of virus into b cells. ebv gp42 binds to the β1 chain of hla-dq, -dr, and -dp on b cells, and uses these molecules for infection. to investigate if certain hla-dq alleles are associated with ebv seronegativity, we recruited ~3,300 healthy adult blood donors, identified 106 ebv-seronegative individuals, and randomly selected a control group of ebv-seropositive donors from the don ... | 2017 | 28239644 |
| ebv early lytic protein bfrf1 alters emerin distribution and post-translational modification. | the nuclear envelope (ne), a structural element of fundamental importance for the cell, is the first barrier that meets a virus in the early stages of viral maturation. therefore, in order to allow the passage of nucleocapsids, viruses are known to modulate the architecture of the nuclear membrane to permit a proficient viral infection. epstein-barr virus (ebv), a pathogen from herpesvirus family, possesses two well conserved proteins, bfrf1 and bflf2, which together form the heterodimeric nucle ... | 2017 | 28238874 |
| corrigendum to "niclosamide inhibits lytic replication of epstein-barr virus by disrupting mtor activation" [(antivir. res.) 138 (2017) 68-78]. | 2017 | 28235454 | |
| amoxicillin-induced generalized eruption associated with epstein-barr virus reactivation in pregnancy. | 2017 | 28233294 | |
| c-myc dysregulation is a co-transforming event for nf-κb activated b-cells. | while c-myc dysregulation is constantly associated with highly proliferating b-cell tumors, nf-κb addiction is found in indolent lymphomas as well as diffuse large b-cell lymphomas either with an activated b-cell like phenotype or associated with epstein-barr virus. we raised the question of the effect of c-myc in b-cells with nf-κb activated by three different inducers: epstein-barr virus-latency iii program, tlr-9 and cd40. induction of c-myc overexpression increased proliferation of epstein-b ... | 2017 | 28232371 |
| reappraisal of ebv in diffuse large b-cell lymphoma (dlbcl): comparative analysis between ebv-positive and -negative dlbcl with ebv-positive bystander cells. | epstein-barr virus (ebv)-positive diffuse large b-cell lymphoma (dlbcl), not otherwise specified (nos) is defined as monoclonal ebv(+) b-cell proliferation affecting patients without any known immunosuppression. non-neoplastic ebv(+) cells proliferating in or adjacent to ebv(-) dlbcl were reported recently, but their clinical significance is unclear. thus, we investigated the prognostic impact of ebv(+) cells in dlbcl. | 2017 | 28231401 |
| developing a multi-component immune model for evaluating the risk of respiratory illness in athletes. | clinical and laboratory identification of the underlying risk of respiratory illness in athletes has proved problematic. the aim of this study was to determine whether clinical data, combined with immune responses to standardised exercise protocols and genetic cytokine polymorphism status, could identify the risk of respiratory illness (symptoms) in a cohort of highly-trained athletes. male endurance athletes (n=16; vo2max 66.5 ± 5.1 ml.kg-1.min-1) underwent a clinical evaluation of known risk f ... | 2017 | 28230530 |
| variation in risk and outcomes of epstein-barr virus-associated breast cancer by epidemiologic characteristics and virus detection strategies: an exploratory study. | a relationship of epstein-barr virus (ebv) and breast cancer etiology and outcome may have clinical utility and potential to enhance understanding of tumor biology. research to date has yielded variable results, likely reflecting differing virus detection assays and unaddressed epidemiologic heterogeneity across studies. | 2017 | 28229344 |
| the swi/snf chromatin regulator, brg1, modulates the transcriptional regulatory activity of the ebv dna polymerase processivity factor bmrf1. | during lytic phase of epstein-barr virus (ebv), binding of the transactivator zta to the origin of lytic replication (orilyt) and the bhlf1 transcript, forming a stable rna-dna hybrid, are required to initiate viral dna replication. ebv-encoded viral dna replication proteins form complexes to amplify viral dna. bmrf1, the viral dna polymerase accessory factor, is essential for lytic dna replication and also known as a transcriptional regulator of the expression of bhlf1 and balf2 (ssdna-binding ... | 2017 | 28228591 |
| crohn's disease complicated by epstein-barr virus-driven haemophagocytic lymphohistiocytosis successfully treated with rituximab. | we report a case of epstein-barr virus (ebv)-driven haemophagocytic lymphohistiocytosis (hlh) in a man with crohn's disease treated with 6-mercaptopurine and adalimumab therapy who was successfully treated with rituximab therapy alone. this is the first published case in an adult patient with ebv-driven hlh in the setting of thiopurine use and inflammatory bowel disease to be successfully treated with rituximab therapy alone. here, we will discuss putative immunological mechanisms which may cont ... | 2017 | 28228435 |
| cd117 (kit) is a useful marker in the diagnosis of plasmablastic plasma cell myeloma. | plasmablastic plasma cell myeloma (ppcm) is a rare morphological presentation of multiple myeloma and can resemble plasmablastic lymphoma (pbl), an hiv related lymphoid neoplasm, morphologically and immunophenotypically. we retrospectively searched for factors that could help differentiate these two entities. | 2017 | 28226184 |
| correlations between epstein-barr virus and acute leukemia. | infection with epstein-barr virus (ebv) may be correlated to the onset of acute leukemia (al). studies were performed to investigate the relationship between ebv infection and immunophenotyping of acute lymphoblastic leukemia (all) and chromosome aberrations. additionally, the effects of ebv on clinical prognosis were described. fluorescence quantitative polymerase chain reaction (fq-pcr) was used to detect ebv-dna copy numbers from bone marrow in 110 cases of patients with all, 75 cases of pati ... | 2017 | 28225168 |
| global trends in nasopharyngeal cancer mortality since 1970 and predictions for 2020: focus on low-risk areas. | nasopharyngeal cancer (npc) mortality shows great disparity between endemic high risk areas, where non-keratinizing carcinoma (nkc) histology is prevalent, and non-endemic low risk regions, where the keratinizing squamous cell carcinoma (kscc) type is more frequent. we used the world health organization database to calculate npc mortality trends from 1970 to 2014 in several countries worldwide. for the european union (eu), the united states (us) and japan, we also predicted trends to 2020. in 20 ... | 2017 | 28224615 |
| cytokine profiles as novel diagnostic markers of epstein-barr virus-associated hemophagocytic lymphohistiocytosis in children. | the aim of this study was to identify specific laboratory indices to distinguish epstein-barr virus-associated hemophagocytic lymphohistiocytosis (ebv-hlh) in children. | 2017 | 28222313 |
| epstein-barr virus-specific adoptive immunotherapy for recurrent, metastatic nasopharyngeal carcinoma. | early-stage and intermediate stage nasopharyngeal cancer (npc) generally carry a good prognosis, but for patients with recurrent, metastatic disease, options are limited. in the current study, the authors present a phase 1/2 study to evaluate the efficacy of epstein-barr virus (ebv)-stimulated cytotoxic t-lymphocyte (ebv-ctl) immunotherapy in this patient population. | 2017 | 28222215 |
| hepatobiliary and pancreatic: epstein-barr virus-associated smooth muscle tumors: unusual cause of hepatic mass in aids patient. | 2017 | 28221693 | |
| characterization of epstein-barr virus-encoded small rna gene variations in virus associated lymphomas in northern china. | epstein-barr virus (ebv)-encoded small rnas (eber1 and eber2) are highly expressed in all forms of ebv latency in ebv-associated malignancies. eber gene variations and their association with ebv-associated disease still remain poorly characterized. to investigate the patterns of eber gene variations and their roles in tumorigenesis, eber gene sequences were analyzed by nested-pcr and dna sequencing in 101 lymphomas from northern china, a non-nasopharyngeal carcinoma (npc) endemic area. in additi ... | 2017 | 28220325 |
| molecular testing for gastrointestinal cancer. | with recent advances in molecular diagnostic methods and targeted cancer therapies, several molecular tests have been recommended for gastric cancer (gc) and colorectal cancer (crc). microsatellite instability analysis of gastrointestinal cancers is performed to screen for lynch syndrome, predict favorable prognosis, and screen patients for immunotherapy. the epidermal growth factor receptor (egfr) tyrosine kinase inhibitor has been approved in metastatic crcs with wildtype ras (kras and nras ex ... | 2017 | 28219002 |
| prognostic role of plasma epstein-barr virus dna load for nasopharyngeal carcinoma: a meta-analysis. | predicting prognosis and treatment outcomes for patients with for nasopharyngeal carcinoma (npc) has been difficult due to the heterogeneous nature of the disease this study aimed to evaluate pretreatment copy number of plasma epstein-barr virus (ebv) dna as an outcome marker for survival in npc. | 2017 | 28218577 |
| coexistence of age-related ebv-associated follicular hyperplasia and large b-cell ebv+ lymphoma of the elderly. two distinct features of the same t-cell dysfunction related to senescence? | age-related ebv-associated lymphoproliferative disorders form a new clinicopathological group. until recently, this group was associated with diffuse large b-cell lymphoma (dlbcl), characterised by an aggressive clinical presentation and a poor prognosis. recent findings in western caucasian patients, however, suggest that this entity covers a wide spectrum of diseases, ranging from reactive follicular hyperplasia (hr) to dlbcl. we report the case of an 85-year-old caucasian man showing lymphade ... | 2017 | 28215641 |
| lymphoepithelioma-like carcinoma of cervix: cytological features on conventional cervical smear. | lymphoepithelioma-like carcinoma (lelc) is a rare neoplasm of the cervix. the importance of distinguishing this undifferentiated carcinoma with a predominant lymphocytic infiltrate lies in the fact that despite being poorly differentiated they have a better prognosis. the diagnosis however becomes more challenging when the pathologist is provided with a small cervical biopsy or a papanicolaou smear. while the reports describing histology and their relation to epstein-barr virus (ebv) are many, t ... | 2017 | 28211234 |
| how we treat chronic active epstein-barr virus infection. | chronic active epstein-barr virus infection (caebv) is a prototype of the ebv-associated t- or nk-cell lymphoproliferative diseases, which also include hypersensitivity to mosquito bites and severe-type hydroavacciniforme. the manifestations of caebv are often self-limiting with minimum supportive care or only prednisolone and cyclosporine a with or without etoposide. however, allogeneic hematopoietic stem cell transplantation (hsct) is the only cure, without which patients with caebv die within ... | 2017 | 28210942 |
| epstein-barr virus-induced mononucleosis as an imitator of severe preeclampsia. | background in pregnancy, conditions presenting with hematologic abnormalities, transaminitis, and proteinuria pose diagnostic challenges in pregnancy. case we present the case of an 18-year-old woman, g1p0, at 33 weeks' gestation with fever of unknown cause, who developed progressively elevated liver enzymes, proteinuria, and thrombocytopenia, due to epstein-barr virus (ebv) infection. conclusion acute infection with ebv should be included in the differential diagnosis of preeclampsia with sever ... | 2017 | 28210518 |
| clinical application of early gastric carcinoma with lymphoid stroma based on lymph node metastasis status. | gastric carcinoma with lymphoid stroma (gcls) is characterized by undifferentiated carcinoma mixed with prominent lymphoid infiltration. gcls has unique clinicopathological features and a better prognosis compared to other types of gastric cancer. we analyzed the clinicopathological features of early gcls in relation to lymph node metastasis (lnm). | 2017 | 28205059 |
| prevalence and significance of plasma epstein-barr virus dna level in nasopharyngeal carcinoma. | 2017 | 28204596 | |
| long term treatment with abatacept or tocilizumab does not increase epstein-barr virus load in patients with rheumatoid arthritis - a three years retrospective study. | epstein-barr virus (ebv) is a widely disseminated lymphotropic herpes virus implicated in benign and malignant disorders. in transplant patients, immunosuppressive drugs (cyclosporine) diminish control of ebv replication, potentially leading to lymphoproliferative disorders (lpd). rheumatoid arthritis (ra) patients have impaired control of ebv infection and have ebv load ten times higher than controls. as post transplant patients, patients with ra have increased risk of developing lymphomas. imm ... | 2017 | 28199343 |
| crispr-cas9-mediated disruption of pd-1 on human t cells for adoptive cellular therapies of ebv positive gastric cancer. | the successful use of immune cell checkpoint inhibitors pd-1 and pd-l1, over the past 5 y has raised the concern of using immunotherapy to treat various cancers. epstein-barr virus-associated gastric cancer (ebvagc) exhibits high infiltration of lymphocytes and high amplification of immune-related genes including pd-l1 as distinguished from epstein-barr virus-non-associated gastric cancer (ebvngc). here, we presume that this pd-1/pd-l1 pathway may hinder the efficacy of adoptive t cell therapy t ... | 2017 | 28197365 |
| the c-terminus of epstein-barr virus brrf2 is required for its proper localization and efficient virus production. | epstein-barr virus (ebv) is a human gammaherpesvirus associated with several malignancies. we reported previously that an ebv lytic gene product brrf2 is involved in the maturation of progeny virus. to analyze the domain(s) needed for efficient production of progeny, we prepared a series of deletion mutants and found two functional domains in the n- and c-terminal regions by complementation assays. immunofluorescence analyses revealed that brrf2 lacking the c-terminal region demonstrated aberran ... | 2017 | 28197146 |
| coxsackie myocarditis and hepatitis with reactivated epstein-bar virus (ebv): a case report. | background myocarditis, defined as inflammation of myocardial tissue of the heart, is an uncommon cardiac presentation and is due to a variety of causes. it affects 1% of the us population, 50% of which is caused by coxsackie b virus. cardiac tissue is the prime target, and destruction of myocardium results in cardiac failure with fluid overload. case report our patient was a 57-year-old woman with fever, headache, neck pain, and generalized malaise. her white blood cell count was 13×10³ cells/m ... | 2017 | 28196967 |
| ebv-induced lymphoproliferative disorders in rheumatic patients: a systematic review of the literature. | epstein-barr virus (ebv) is involved in the pathogenesis of approximately 40% of lymphoproliferative disorders (lpds) arising in patients receiving immunosuppressive treatment (ist) for rheumatic diseases, but data from large cohorts are still not available. we aimed to identify clinicopathological features, management and outcome of this condition. | 2017 | 28196776 |
| fibrin-associated ebv-positive large b-cell lymphoma: an indolent neoplasm with features distinct from diffuse large b-cell lymphoma associated with chronic inflammation. | incidental cases of localized fibrin-associated epstein-barr virus (ebv)+ large b-cell proliferations have been described at unusual anatomic sites and have been included in the category of diffuse large b-cell lymphoma associated with chronic inflammation (dlbcl-ci) in the who classification. we describe 12 cases and review the literature to define their clinicopathologic spectrum and compare features with typical cases of dlbcl-ci. median age was 55.5 years with a m:f ratio of 3. in all 12 cas ... | 2017 | 28195879 |
| metastatic nasopharyngeal carcinoma presenting as an isolated breast mass: a diagnostic pitfall and a review of literature. | metastases to breast are much rarer than primary breast tumors. we now present a case of 45-year-old female, who presented with an isolated breast mass. a positron emission tomography-computed tomography (pet-ct) done revealed hypermetabolic right breast nodules, soft tissue deposits, and multiple nodal involvement. the biopsy from the breast and axillary lymph node showed dense lymphoid infiltrate and was interpreted initially as granulomatous inflammation. however, the lumps were hard and susp ... | 2017 | 28195109 |
| a paper-based platform for detection of viral rna. | viral detection presents a host of challenges for even the most sensitive analytical techniques, and the complexity of common detection platforms typically preclude portability. with these considerations in mind, we designed a paper microzone plate-based virus detection system for the detection of viral genetic material that can be performed with simple instruments. the sensing system can detect viral cdna reverse-transcribed from total rna extraction by utilizing a biotinylated capture probe an ... | 2017 | 28194453 |
| acute acalculous cholecystitis: a rare presentation of primary epstein-barr virus infection in adults-case report and review of the literature. | primary epstein-barr virus (ebv) infection is almost always a self-limited disease characterized by sore throat, fever, and lymphadenopathy. hepatic involvement is usually characterized by mild elevations of aminotransferases and resolves spontaneously. although isolated gallbladder wall thickness has been reported in these patients, acute acalculous cholecystitis is an atypical presentation of primary ebv infection. we presented a young women admitted with a 10-day history of fever, nausea, mal ... | 2017 | 28194287 |
| nk/t cell lymphoma: a tertiary centre experience. | extranodal nk/t-cell lymphoma (enktl), nasal type, is a rare type of non-hodgkin lymphoma that is commonly seen in east asian countries and is associated with epstein-barr virus infection. this is a retrospective study where we describe nine cases of enktl; nasal type diagnosed and treated at our center over a period of 2 years. these cases were analyzed retrospectively for clinical presentation (age, sex, site of involvement), immunophenotype, treatment, response and toxicity profile. sino-nasa ... | 2017 | 28194059 |
| a case report of primary nasal natural killer (nk)/t-cell lymphoma in an african american patient presenting with hemophagocytic syndrome. | background extranodal natural killer/t-cell lymphoma, nasal type (enktcl) is generally an aggressive and rare non-hodgkin lymphoma. it is most common in east asians, native americans, and south americans, but is rarely reported in blacks. case report a 55-year-old african american male born in grenada presented with a left nostril mass with facial swelling and biopsy subsequently confirmed a diagnosis of extranodal nk/t-cell lymphoma, nasal type (enktcl). immunochemistry was positive for cd2, cy ... | 2017 | 28193996 |
| streptococcus gallolyticus infection in colorectal cancer and association with biological and clinical factors. | there is an unambiguous association of streptococcus gallolyticus infection with colorectal cancer, although there is limited information about epidemiology or interaction between molecular and environmental factors. we performed an original quantitative analysis of s. gallolyticus in unselected colorectal cancer patients (n = 190) and their association with clinical, pathological tumor molecular profiles (microsatellite instability, hypermethylator phenotype and chromosomal instability pathways ... | 2017 | 28355283 |
| mouse model of epstein-barr virus lmp1- and lmp2a-driven germinal center b-cell lymphoproliferative disease. | epstein-barr virus (ebv) is a major cause of immunosuppression-related b-cell lymphomas and hodgkin lymphoma (hl). in these malignancies, ebv latent membrane protein 1 (lmp1) and lmp2a provide infected b cells with surrogate cd40 and b-cell receptor growth and survival signals. to gain insights into their synergistic in vivo roles in germinal center (gc) b cells, from which most ebv-driven lymphomas arise, we generated a mouse model with conditional gc b-cell lmp1 and lmp2a coexpression. lmp1 an ... | 2017 | 28351978 |
| epstein-barr virus and its association with fascin expression in colorectal cancers in the syrian population: a tissue microarray study. | colorectal cancer (crc) is the third most common malignancy in both men and women worldwide. colorectal carcinogenesis is a complex, multistep process involving environmental and lifestyle features as well as sequential genetic changes in addition to bacterial and viral infections. viral infection has a proven role in the incidence of approximately 20% of human cancers including gastric malignancies. accordingly, epstein-barr virus (ebv) has been recently shown to be present in human gastric can ... | 2017 | 28350509 |
| etiologic association between epstein-barr virus and oral squamous cell carcinoma: a brief evidence-based discussion. | epstein-barr virus (ebv), also known as human herpes virus-4, belongs to the γ-subfamily of herpes viruses.(1) nearly 90 to 95% of the world's adult population is an asymptomatic carrier of ebv.(1-3). | 2017 | 28349901 |
| ebv induces persistent nf-κb activation and contributes to survival of ebv-positive neoplastic t- or nk-cells. | epstein-barr virus (ebv) has been detected in several t- and nk-cell neoplasms such as extranodal nk/t-cell lymphoma nasal type, aggressive nk-cell leukemia, ebv-positive peripheral t-cell lymphoma, systemic ebv-positive t-cell lymphoma of childhood, and chronic active ebv infection (caebv). however, how this virus contributes to lymphomagenesis in t or nk cells remains largely unknown. here, we examined nf-κb activation in ebv-positive t or nk cell lines, snt8, snt15, snt16, snk6, and primary e ... | 2017 | 28346502 |
| epithelioid cell granuloma in the bone marrow secondary to epstein-barr virus infection. | 2017 | 28346186 | |
| correlation between epstein-barr virus infection and disease activity of systemic lupus erythematosus: a cross-sectional study | background: systemic lupus erythematosus (sle) is an autoimmune disease for whose pathogenesis viral infections are important. the epstein-barr virus (ebv) is the main infectious etiological agent. this study aimed to quantitative evaluation of ebv in sle patients. materials and methods: in this cross-sectional study, 40 patients with sle diagnosed based on american college of rheumatology criteria were selected using purposive sampling. all were included in the study after obtaining informed co ... | 2017 | 28345840 |
| frequency of epstein barr virus type 1 among nasopharyngeal carcinomas in iranian patients | background: around 95% of the world’s population are infected with the epstein-barr virus (ebv), which can persist latent in b lymphocytes and epithelial cells life-long. ebv has been linked with lymphoid and epithelial cancers and persistence of ebv infection in lymphoid or epithelial cells may result in virus-associated b-cell tumors or nasopharyngeal carcinomas (npc). this study was conducted to determine the frequency of ebv dna in nasopharyngeal carcinoma tissue of iranian patients. materia ... | 2017 | 28345327 |
| pre-emptive and therapeutic adoptive immunotherapy for nasopharyngeal carcinoma: phenotype and effector function of t cells impact on clinical response. | adoptive t cell therapy has emerged as a powerful strategy to treat human cancers especially haematological malignancies. extension of these therapies to solid cancers remains a significant challenge especially in the context of defining immunological correlates of clinical responses. here we describe results from a clinical study investigating autologous epstein-barr virus (ebv)-specific t cells generated using a novel ade1-lmppoly vector to treat patients with nasopharyngeal carcinoma (npc) ei ... | 2017 | 28344888 |
| 2b4-sap signaling is required for the priming of naive cd8(+) t cells by antigen-expressing b cells and b lymphoma cells. | mutations in sh2d1a gene that encodes sap (slam-associated protein) result in x-linked lymphoproliferative disease (xlp), a rare primary immunodeficiency disease defined by exquisite sensitivity to the b-lymphotropic epstein-barr virus (ebv) and b cell lymphomas. however, the precise mechanism of how the loss of sap function contributes to extreme vulnerability to ebv and the development of b cell lymphomas remains unclear. here, we investigate the hypothesis that sap is critical for cd8(+) t ce ... | 2017 | 28344876 |
| periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (pfapa) syndrome in children. | periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (pfapa) syndrome refers to a group of primary immunodeficiencies, namely autoinflammatory diseases. most pediatricians and otolaryngologists do not suspect pfapa syndrome when treating recurrent pharyngitis (according to ukrainian classification - tonsillitis) and stomatitis. therefore, patients with a given syndrome receive unnecessary treatment (antibiotic therapy or antiviral drugs) and the diagnosis is made late. the aim ... | 2017 | 28343210 |
| clinicopathological analysis of primary central nervous system nk/t-cell lymphoma: rare and localised aggressive tumour among extranasal nk/t-cell tumours. | the central nervous system (cns) is a rare primary site of non-hodgkin lymphoma. although direct invasion of nasal nk/t-cell tumours into cns is occasionally reported, primary cns nk/t-cell lymphoma is extremely rare, and the clinicopathological features of primary cns nk/t-cell lymphoma remain largely unknown. | 2017 | 28342197 |
| elevated serum levels of scd30 and il-6 and detectable il-10 precede classical hodgkin lymphoma diagnosis. | we investigated whether an immune system environment characterized by elevated serum levels of b-cell activation molecules was associated with the subsequent development of classical hodgkin lymphoma (chl). | 2017 | 28341757 |
| a p110δ-specific inhibitor combined with bortezomib blocks drug resistance properties of ebv-related b cell origin cancer cells via regulation of nf-κb. | epstein-barr virus (ebv) infection is closely related to carcinogenesis of various cancers, and is also associated with the development of drug resistance in cancer stem cells. however, in ebv-positive cancer cells, the mechanistic details of the downstream signaling and the connection of pi3k with the nf-κb pathway for development of drug resistance remain controversial. diffuse large b-cell lymphoma (dlbcl) and multiple myeloma (mm) cells infected by ebv display drug resistance-related protein ... | 2017 | 28339079 |
| hla expression and hla type associations in relation to ebv status in hispanic hodgkin lymphoma patients. | a proportion of classical hodgkin lymphomas harbor the epstein barr virus (ebv). we previously demonstrated that associations between human leukocyte antigen (hla) alleles and susceptibility to ebv+ classical hodgkin lymphoma differ between european and chinese populations. data on hispanic populations is missing. here we examined the association between hla type, tumor cell hla expression and other characteristics in hispanic hodgkin lymphoma patients. hispanic hodgkin lymphoma patients diagnos ... | 2017 | 28334025 |
| epstein-barr virus lytic reactivation activates b cells polyclonally and induces activation-induced cytidine deaminase expression: a mechanism underlying autoimmunity and its contribution to graves' disease. | graves' disease is an autoimmune disease that results in and is the most common cause of hyperthyroidism, and the reactivation of persisting epstein-barr virus (ebv) in b lymphocytes induces the differentiation of host b cells into plasma cells. we previously reported that some ebv-infected b cells had thyrotropin receptor antibodies (trabs) as surface immunoglobulins (igs), and ebv reactivation induced these trab+ebv+ cells to produce trabs. ebv reactivation induces ig production from host b ce ... | 2017 | 28333576 |
| evaluation of lipid profile changes in pediatric patients with acute mononucleosis. | acute epstein-barr virus (ebv) infection could lead to atherogenic lipid profile changes in adults; while there is no evidence about the children with infectious mononucleosis (im). the aim of this study was to evaluate the lipid profile of the children in acute phase of mononucleosis and two months after the recovery. | 2017 | 28332346 |
| a novel recombinant variant of latent membrane protein 1 from epstein barr virus in argentina denotes phylogeographical association. | to study lmp1 variants distribution among children with ebv+ malignant and benign conditions as well as in healthy carriers. | 2017 | 28328987 |
| dacryoadenitis as the initial presentation of a natural killer t-cell lymphoma. | primary orbital natural killer t-cell lymphoma (nktcl) is a rare condition with only a few published cases in the literature. over 1 month, an 81-year-old man developed progressive left periocular inflammation unresponsive to treatment. clinical examination and imaging studies demonstrated a left lacrimal gland enlargement. bilateral anterior uveitis and erythematous nontender cutaneous lesions were also found. biopsies of the skin and lacrimal gland on the back revealed histopathologic and immu ... | 2017 | 28328558 |
| solitary plasmacytoma associated with epstein-barr virus: a clinicopathologic, cytogenetic study and literature review. | solitary plasmacytoma (sp) is an uncommon, indolent tumor of plasma cell neoplasms that presents as a mass lesion in extramedullary sites. evidence of epstein-barr virus (ebv) infection is frequently associated with various lymphatic and hematopoietic malignancies but is relatively rare in sp. moreover, it is essential to distinguish ebv-positive plasmacytoma from plasmablastic lymphoma. in this study, we found 4 ebv-encoded rna (eber)-positive patients among 46 consecutive immunocompetent patie ... | 2017 | 28325354 |
| epstein-barr virus gastritis. | 2017 | 28321083 | |
| epstein-barr virus-associated lymphoproliferative disorder with encephalitis following anti-thymocyte globulin for aplastic anemia resolved with rituximab therapy: a case report and literature review. | epstein-barr virus (ebv)-associated lymphoproliferative disorders (lpds) sometimes occur following anti-thymocyte globulin (atg) administration for allogenic stem cell transplantation but are rare in aplastic anemia (aa) patients. a 55-year-old woman with aa following atg developed refractory fever and was diagnosed with ebv-lpd. she was successfully treated with weekly rituximab monotherapy; however, she developed ebv encephalitis. she was admitted to the intensive care unit and finally recover ... | 2017 | 28321074 |
| case of lymphadenopathy with lytic bone lesions. | plasmablastic lymphoma, a rare highly aggressive non-hodgkin's lymphoma subtype, often associated with hiv infection, is a close differential diagnosis of plasmablastic myeloma. the 2 conditions may be morphologically and immunophenotypically identical. however, differentiating between the 2 conditions is critical for adequate patient management. herein, we describe an unusual case of plasmablastic myeloma with biclonal gammopathy which was initially diagnosed as plasmablastic lymphoma based on ... | 2017 | 28320703 |
| type ii enteropathy-associated t-cell lymphoma: a rare report from iran. | type ii enteropathy-associated t-cell lymphoma (eatl) is a rare disease that is reported from asia, especially from taiwan. in this paper, we present a patient from iran (arab) with type ii eatl whose disease was not associated with celiac disease or epstein-barr virus (ebv) infection. the patient died due to intestinal perforation during the first chemotherapy. type ii eatl is a gastrointestinal lymphoma with poor prognosis and a high affinity for intestinal perforation. early detection of eatl ... | 2017 | 28316767 |
| the clinical significance of epstein-barr virus dna in peripheral blood mononuclear cells in patients with non-hodgkin lymphoma. | the aim of the study was to determine the clinical significance of ebv dna in the peripheral blood mononuclear cells (pbmcs) from the patients with non-hodgkin lymphoma (nhl). newly diagnosed patients with nhl were enrolled in the study (n = 328), and clinical data retrospectively analyzed. ebv dna was detectable in 34.8% of patients, and the positivity rate was 51.6% for t/nk cell subtype and 24.3% for b cell subtype (p < .001). in diffuse large b cell lymphoma (dlbcl), extranodal nk/t-cell lym ... | 2017 | 28306367 |
| lymphoproliferative disease after pediatric liver transplant. | posttransplant lymphoproliferative disease is a major complication following solid-organ transplant. we summarize the relation of epstein-barr virus to this complication and discuss its treatment in pediatric patients. | 2017 | 28302005 |
| clinical significance of spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia in ebv-associated and ebv-negative gastric cancer. | spasmolytic polypeptide-expressing metaplasia (spem) and intestinal metaplasia (im) have been recognized as neoplastic precursors in gastric carcinogenesis. we explored the relationship between spem and im in epstein-barr virus-associated (ebvagc) and epstein-barr virus-negative (ebvngc) gastric cancer. 64 ebvagc and 154 ebvngc patients were included. ebv-positivity was identified using eber-1 in situ hybridization. spem was sub-classified into absent, early and advanced spem. acute and chronic ... | 2017 | 28300576 |
| roles of runx in b cell immortalisation. | runx1 and runx3 are the main runx genes expressed in b lymphocytes. both are expressed throughout b-cell development and play key roles at certain key developmental transitions. the tumour-associated epstein-barr virus (ebv) has potent b-cell transforming ability and manipulates runx3 and runx1 transcription through novel mechanisms to control b cell growth. in contrast to resting mature b cells where runx1 expression is high, in ebv-infected cells runx1 levels are low and runx3 levels are high. ... | 2017 | 28299664 |
| unveiling another missing piece in ebv-driven lymphomagenesis: ebv-encoded micrornas expression in eber-negative burkitt lymphoma cases. | epstein-barr virus (ebv) is a gammaherpesvirus linked to a number of lymphoid and epithelial malignancies, including burkitt lymphoma (bl) in which its frequency ranges from 30% in sporadic cases to 100% in the endemic ones. the possible contribution of ebv to bl pathogenesis is largely unknown. it has been suggested that ebv may be associated with all of the cases, including those diagnosed as ebv negative by a mechanism of hit-and-run. early during oncogenesis, viral genes are essential for in ... | 2017 | 28298901 |
| a workflow for in silico design of hil-10 and ebvil-10 inhibitors using well-known miniprotein scaffolds. | the over-expression of immune-suppressors such as il-10 is a crucial landmark in both tumor progression, and latent viral and parasite infection. il-10 is a multifunctional protein. besides its immune-cell suppressive function, it also promotes b-cell tumorigenesis of lymphomas and melanoma. human pathogens like unicellular parasites and viruses that remain latent inside b cells promote the over-expression of hil-10 upon infection, which inhibits cell-mediated immune surveillance, and at the sam ... | 2017 | 28293795 |
| dock 8 deficiency, ebv+ lymphomatoid granulomatosis, and intrafamilial variation in presentation. | dedicator of cytokinesis 8 (dock8) deficiency is an autosomal recessive, combined immunodeficiency within the spectrum of hyper-ige syndromes. epstein-barr virus-positive lymphomatoid granulomatosis (lyg) (ebv + lyg) is a rare diagnosis and a previously unreported presentation of dock8 deficiency. a 10-year-old girl was initially evaluated for mild eczema and recurrent sinopulmonary infections. she had normal immunoglobulins with elevated ige, poor polysaccharide response with low switched memor ... | 2017 | 28293550 |
| epstein-barr virus in the pathogenesis of oral cancers. | epstein-barr virus (ebv) is a ubiquitous gammaherpesvirus that establishes a lifelong persistent infection in the oral cavity and is intermittently shed in the saliva. ebv exhibits a biphasic life cycle, supported by its dual tropism for b lymphocytes and epithelial cells, which allows the virus to be transmitted within oral lymphoid tissues. while infection is often benign, ebv is associated with a number of lymphomas and carcinomas that arise in the oral cavity and at other anatomical sites. i ... | 2017 | 28190296 |
| mutation analysis of tumor necrosis factor alpha-induced protein 3 gene in hodgkin lymphoma. | survival and proliferation of hodgkin and reed-sternberg (hrs) cells, the malignant cells of classical hodgkin lymphoma (chl), are dependent on constitutive activation of nuclear factor kb (nf-κb). a20, encoded by tnf alpha-induced protein 3 (tnfaip3), one of the inhibitors of nf-kb, was found to be inactivated by deletions and/or point mutations in chl. | 2017 | 28189285 |
| alice in wonderland syndrome: a real life version of lewis carroll's novel. | alice in wonderland syndrome was originally coined by dr. john todd in 1955. the syndrome is named after the sensations experienced by the character alice in lewis carroll's novel alice's adventures in wonderland. alice in wonderland syndrome consists of metamorphopsia (seeing something in a distorted fashion), bizarre distortions of their body image, and bizarre perceptual distortions of form, size, movement or color. additionally, patients with alice in wonderland syndrome can experience audit ... | 2017 | 28189272 |
| pd1 blockade with pembrolizumab is highly effective in relapsed or refractory nk/t-cell lymphoma failing l-asparaginase. | natural killer (nk)/t-cell lymphomas failing l-asparaginse-regimens have no known salvage and are almost invariably fatal. seven male nk/t-cell lymphoma patients (age: 49, 31-68, years) failing 2 (1-5) regimens (including l-asparaginase-regimens, and allogeneic hematopoietic stem cell transplantation, hsct, in 2 cases), were treated with the anti-programmed-death-1 (pd1) antibody pembrolizumab. all patients responded, according to various clinical, radiologic (positron emission tomography), morp ... | 2017 | 28188133 |
| epstein-barr virus particles induce centrosome amplification and chromosomal instability. | infections with epstein-barr virus (ebv) are associated with cancer development, and ebv lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. here we report that ebv infection of b-lymphocytes (in vitro and in a mouse model) leads to an increased rate of centrosome amplification, associated with chromosomal instability. this effect can be reproduced with virus-like particles devoid of ebv dna, but not with defective virus-like particles that ... | 2017 | 28186092 |
| epstein-barr virus-associated gastric cancer reveals intratumoral heterogeneity of pik3ca mutations. | 2017 | 28184407 | |
| serum proteomic-based analysis identifying autoantibodies against prdx2 and prdx3 as potential diagnostic biomarkers in nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is a major head and neck cancer with high occurrence in southeast asia and southern china. we aimed to identify autoantibodies that may contribute to early detection of npc. | 2017 | 28184180 |
| next-generation sequencing of mirnas in clinical samples of epstein-barr virus-associated b-cell lymphomas. | epstein-barr virus (ebv) encodes 49 micrornas (mirnas) in the bart and bhrf1 regions of its genome. although expression profiles of ebv-encoded mirnas have been reported for ebv-positive cell lines and nasopharyngeal carcinoma, to date there is little information about total mirna expression, including cellular and viral mirnas, in the primary tumors of ebv-associated b-lymphoproliferative disorders. in this study, next-generation sequencing and quantitative real-time reverse transcription-pcr w ... | 2017 | 28181423 |
| the prognostic value and pathobiological significance of glasgow microenvironment score in gastric cancer. | to evaluate the prognostic value and pathobiological significance of glasgow microenvironment score (gms), a parameter based on tumor stroma percentage and inflammatory cell infiltration, in gastric cancer. | 2017 | 28180998 |
| "hemophagocytic lymphohistiocytosis after ebv reactivation and ibrutinib treatment in relapsed/refractory chronic lymphocytic leukemia". | hemophagocytic lymphohistiocytosis (hlh) is a rare syndrome characterized by ineffective t-cell and nk response. we report the clinical course of a patient with relapsed cll who developed acute symptoms soon after starting ibrutinib. hyperpyrexia, splenomegaly, hyperferritinemia, hypertriglyceridemia, cytopenias, and a typical cytokine pattern, i.e. high interleukin (il)-6, il10 and il18, were consistent with a diagnosis of hlh. coexistent epstein barr virus reactivation was documented. ibrutini ... | 2017 | 28180067 |