Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| development and evaluation of a quantitative, touch-down, real-time pcr assay for diagnosing pneumocystis carinii pneumonia. | a rapid (time to completion, <4 h, including dna extraction) and quantitative touch-down (qtd) real-time diagnostic pneumocystis carinii pcr assay with an associated internal control was developed, using fluorescence resonance energy transfer (fret) probes for detection. the touch-down procedure significantly increased the sensitivity of the assay compared to a non-touch-down procedure. tenfold serial dilutions of a cloned target were used as standards for quantification. p. carinii dna has been ... | 2002 | 11825961 |
| [trimethoprim-sulfamethoxazole as antibacterial prophylaxis during induction therapy of children with acute lymphatic leukemia]. | children with acute lymphoblastic leukaemia (all) are treated with intensive chemotherapy, which results in profound immunosuppression. treatment with trimethoprim/sulphamethoxazole (tmp-smx) is therefore used in some departments as prophylaxis against infections with both bacteria and pneumocystis carinii. the use of tmp/smx for prophylaxis during the induction therapy is not uniform in the four departments of paediatric oncology in denmark. this gave us the opportunity to describe the effect o ... | 2002 | 11838420 |
| efficacy of trimethoprim-sulfamethoxazole for the prevention of bacterial infections in a randomized prophylaxis trial of patients with advanced hiv infection. | we compared the occurrences of several types of infections in hiv-infected patients participating in a randomized clinical trial of three treatment strategies given for the primary prevention of pneumocystis carinii pneumonia (pcp) and toxoplasmosis. in a phase iii open label trial, 842 patients with hiv infection and fewer than 200 cd4+ cells/mm(3) received zidovudine (standard dose) plus one of three randomly assigned prophylactic agents: trimethoprim-sulfamethoxazole (tmp-smz), or dapsone (da ... | 2002 | 11839141 |
| hypercalcemia in a renal transplant recipient suffering with pneumocystis carinii pneumonia. | hypercalcemia occurs frequently after renal transplantation. preexisting hyperparathyroidism is the most common cause of post-transplantation hypercalcemia. we describe a renal transplant recipient infected with pneumocystis carinii pneumonia (pcp) who developed hypercalcemia, elevated 1,25-dihydroxyvitamin d, and suppressed parathyroid hormone levels. this phenomenon mimics the extrarenal production of 1,25-dihydroxyvitamin d by activated alveolar macrophages in granulomatous diseases with hype ... | 2002 | 11840399 |
| follicular bronchiolitis associated with legionella pneumophilia infection. | an 8-month-old girl with respiratory distress and stridor was admitted to our hospital. two days later, she died of respiratory insufficiency due to pneumonia. autopsy confirmed the presence of follicular bronchiolitis (fbb) in both lungs. after consideration of her clinical course, we focused on three pathogens: legionella pneumophilia, pneumocystis carinii, and mycobacterium tuberculosis. only legionella pneumophilia was detected by both immunohistochemistry and polymerase chain reaction. | 2002 | 11842978 |
| antileishmanial activities of several classes of aromatic dications. | aromatic dicationic molecules possess impressive activity against a broad spectrum of microbial pathogens, including pneumocystis carinii, cryptosporidium parvum, and candida albicans. in this work, 58 aromatic cations were examined for inhibitory activity against axenic amastigote-like leishmania donovani parasites. in general, the most potent of the compounds were substituted diphenyl furan and thiophene dications. 2,5-bis-(4-amidinophenyl)thiophene was the most active compound. this agent dis ... | 2002 | 11850264 |
| the radiologic differential diagnosis of diffuse lung diseases characterized by multiple cysts or cavities. | a variety of pulmonary diseases have diffuse cystic abnormalities within the lungs, including emphysema, cystic bronchiectasis, desquamative interstitial pneumonia, lymphocytic interstitial pneumonia, usual interstitial pneumonia, lymphangioleiomyomatosis, langerhans histiocytosis, cystic metastasis, wegener granulomatosis, pneumocystis carinii pneumonia, pulmonary paragonimiasis, and septic pulmonary emboli. ct can easily detect cystic abnormalities as common features in many diseases. however, ... | 2002 | 11801898 |
| passive intranasal monoclonal antibody prophylaxis against murine pneumocystis carinii pneumonia. | passive antibody immunoprophylaxis is one method used to protect patients against infection if they are unable to mount an adequate active immune response. topical application of antibody may be effective against infections at mucosal sites. using a scid mouse model of pneumocystis carinii pneumonia, we were able to demonstrate protection against an airborne challenge with p. carinii by intranasal administration of antibody. immunoglobulin m (igm) monoclonal antibodies to an epitope shared by mo ... | 2002 | 11854184 |
| [pulmonary complications in patients with aids]. | hiv infection was first reported in 1981 in usa. it has been 20 years since then. owing to understandings of pathogenesis of this disease and development of new drugs such as the hiv-specific protease inhibitor (pi), prognosis of disease has been tremendously improved. especially after 1997 in japan, the strategy of anti-hiv treatment shifted from two drugs combination to three drugs combination, which is called highly active antiretoviral therapy (haart). haart was so effective that prevalence ... | 2002 | 11855078 |
| genetic diversity of pneumocystis carinii f. sp. hominis based on variations in nucleotide sequences of internal transcribed spacers of rrna genes. | a variety of genes have been used to type pneumocystis carinii. in the present study, nucleotide sequence variations in the its1 and its2 internal transcribed spacer (its) regions of the rrna genes were used to type pneumocystis carinii f. sp. hominis dna obtained from the lungs of 60 human immunodeficiency virus-infected individuals. these regions were amplified by pcr, cloned, and sequenced. multibase polymorphisms were identified among samples. several new genotypes are reported on the basis ... | 2002 | 11923323 |
| probable mother-to-infant transmission of pneumocystis carinii f. sp. hominis infection. | a mother and her 4.5-week-old infant had pneumocystis carinii pneumonia contemporaneously. genotyping of p. carinii f. sp. hominis dna at three independent loci showed the same genotype in samples from mother and infant. these data suggest transmission of p. carinii organisms from the mother to her infant. | 2002 | 11923396 |
| management of opportunistic infection prophylaxis in the highly active antiretroviral therapy era. | prophylaxis and maintenance therapy against opportunistic infections are a mainstay of management of hiv-infected patients and have led to a significant improvement in quality of life and survival. antiretroviral combination therapy (art) has markedly changed the natural course of hiv infection. incidence of opportunistic infections (ois) has declined and survival after an oi has improved. achieving a cd4 count of 200 cells/l after 6 months of art is a valuable marker for low risk of oi afterwar ... | 2002 | 11927049 |
| pathology and causes of death in a group of 128 predominantly hiv-positive patients in botswana, 1997-1998. | little is known about causes of death in countries of southern africa seriously affected by the hiv/aids epidemic. | 2002 | 11931402 |
| frequency and type of serious infections in fludarabine-refractory b-cell chronic lymphocytic leukemia and small lymphocytic lymphoma: implications for clinical trials in this patient population. | treatments for fludarabine-refractory chronic lymphocytic leukemia (cll)/small lymphocytic lymphoma (sll) are limited. most new therapies being examined in fludarabine-refractory patients have shown a high frequency of serious infection. little data exist regarding the frequency of infections in this population treated with noninvestigational best supportive care therapies. | 2002 | 11932906 |
| morbidity and mortality in south african gold miners: impact of untreated disease due to human immunodeficiency virus. | a cohort of 1792 human immunodeficiency virus (hiv)-positive and 2970 hiv-negative south african miners was observed for 12 months starting in february 1998. all-cause hospitalizations and deaths were significantly associated with hiv infection (respective unadjusted incidence rate ratios, 2.9 and 9.2; respective 95% confidence intervals, 2.5-3.4 and 5.5-16.0). tuberculosis (tb), bacterial pneumonia, cryptococcosis, and trauma were the major causes of admission for hiv-positive patients, whereas ... | 2002 | 11941552 |
| pneumocystis carinii infection in bilateral aural polyps in a human immunodeficiency virus-positive patient. | pneumocystis carinii is an opportunistic infection found in patients with impaired immunity. under favourable conditions the parasite can spread via the blood stream or lymphatic vessels and cause extrapulmonary dissemination. we report a case of p carinii infection presenting as bilateral aural polyps, otitis media and mastoiditis in human immunodeficiency (hiv)-positive patient with no history of prior or concomitant p carinii infection. | 2002 | 11945191 |
| identification of pneumocystis carinii dna by polymerase chain reaction in necropsy lung samples from children dying of respiratory tract illnesses. | polymerase chain reaction for pneumocystis carinii dna was performed on necropsy lung samples from children by means of p carinii -specific primers.p carinii dna was identified in 22 of 22 (100%) samples with histologically proven p carinii pneumonia and 13 of 75 (17%) with non-p carinii pneumonia respiratory illness (sensitivity, 100%; specificity, 83%). the low specificity precludes the use of polymerase chain reaction as an alternative to histopathologic diagnosis. | 2002 | 11953737 |
| n-terminal n-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differences. | n-terminal n-myristoylation is a lipid anchor modification of eukaryotic and viral proteins targeting them to membrane locations, thus changing the cellular function of modified proteins. protein myristoylation is critical in many pathways; e.g. in signal transduction, apoptosis, or alternative extracellular protein export. the myristoyl-coa:protein n-myristoyltransferase (nmt) recognizes the sequence motif of appropriate substrate proteins at the n terminus and attaches the lipid moiety to the ... | 2002 | 11955007 |
| opportunistic infections: an update. | with highly active antiretroviral therapy (haart), the overall incidence of opportunistic infections (ois) has declined and survival after an aids-defining event has improved. however, rates of mycobacterial diseases and cytomegalovirus (cmv) disease remain high for the first 3 months before declining. achieving a cd4 count of 200 cells/ micro l after 6 months of haart is a valuable marker for a subsequent low risk of ois. different clinical manifestations of ois may be attributable to immunopat ... | 2002 | 11956497 |
| pneumocystis carinii: where are we now? | pneumocystis carinii pneumonia (pcp) is still the commonest aids-defining condition in the uk, although absolute numbers have fallen since 1990 with the advent of prophylaxis and highly active antiretroviral therapy (haart). further decreases in its incidence are unlikely unless efforts are made to reduce late first presentations of hiv, improve retention of patients in care and improve adherence to p. carinii prophylaxis. the widespread development of key mutations in the p. carinii dihydropter ... | 2002 | 11956498 |
| arterial splenic calcifications in children with aids: two case reports. | splenic calcifications in aids patients are usually round and result from infections with opportunistic pathogens such as pneumocystis carinii, mycobacterium avium-intracellulare and cytomegalovirus. we describe here a remarkable echopattern of the spleen in two pediatric patients, resulting from linear, branching calcifications in the splenic parenchymal arteries. we believe this echopattern represents the ultrasonographic manifestation of an hiv-associated vasculopathy. | 2002 | 11956733 |
| prophylaxis for human immunodeficiency virus-related pneumocystis carinii pneumonia: using simulation modeling to inform clinical guidelines. | human immunodeficiency virus (hiv)-infected patients receiving highly active antiretroviral therapy (haart) have experienced a dramatic decrease in pneumocystis carinii pneumonia (pcp), necessitating reassessment of clinical guidelines for prophylaxis. | 2002 | 11966344 |
| [diagnostic criteria for hiv/aids in japan]. | in japan, criteria for the diagnosis of hiv infection and aids have been revised in 1999. for the diagnosis of hiv infection, hiv-positivity has to be confirmed by western blot test or nucleic acid tests such as pcr for hiv when the results of screening tests for anti-hiv antibodies (elisa) are positive. diagnosis of aids can be made when hiv-infected persons show any one of 23 indicator diseases. criteria for the diagnosis of these 23 diseases are described. the indicator disease most frequentl ... | 2002 | 11968774 |
| [clinical impact of combination antiretroviral therapy]. | after the advent of hiv protease inhibitor in 1995, the clinical feature of hiv disease has been dramatically changed. combination antiretroviral therapy containing protease inhibitor can suppress the viral load under the detection limit and recover the immune status in hiv-infected individuals. however, it still seems impossible to eradicate the viruses from infected individuals. they will have to continue the combination therapy for life with good compliance because incomplete viral suppressio ... | 2002 | 11968781 |
| pneumocystis carinii pneumonia in patients with malignant haematological diseases: 10 years' experience of infection in gimema centres. | a retrospective survey was conducted over a 10-year period (1990-99) among 52 haematology divisions in order to evaluate the clinical and laboratory characteristics and outcome of patients with proven pneumocystis carinii pneumonia (pcp) complicating haematological diseases. the study included 55 patients (18 with non-hodgkin's lymphoma, 10 with acute lymphoblastic leukaemia, eight with acute myeloid leukaemia, five with chronic myeloid leukaemia, four with chronic lymphocytic leukaemia, four wi ... | 2002 | 11972521 |
| [spontaneous resolution of pneumocystis carinii pneumonia]. | a 58-year-old woman was admitted to our hospital complaining of fever, dry cough, and exertional dyspnea. chest radiographs showed diffuse interstitial infiltrates in both lungs, and blood gas analysis showed moderate hypoxemia. the levels of serum kl-6 and beta-d-glucan were markedly elevated. bronchoscopy was performed and pneumocystis carinii was found in the balf and transbronchial lung biopsy specimens. a positive reaction for the htlv-i antibody was obtained, and htlv-i proviral dna was de ... | 2002 | 11974868 |
| use of recombinant cellulose-binding domains of trichoderma reesei cellulase as a selective immunocytochemical marker for cellulose in protozoa. | some unicellular organisms are able to encyst as a protective response to a harmful environment. the cyst wall usually contains chitin as its main structural constituent, but in some cases, as in acanthamoeba, it consists of cellulose instead. specific cytochemical differentiation between cellulose and chitin by microscopy has not been possible, due to the similarity of their constituent beta-1,4-linked hexose backbones. thus, various fluorescent brightening agents and lectins bind to both cellu ... | 2002 | 11976127 |
| lipopolysaccharide-binding protein as a new and reliable infection marker after kidney transplantation. | the early and reliable differentiation of rejections, viral infections and bacterial infections is one of the main problems after organ transplantation. one promising solution to this problem is the lipopolysaccharide-binding protein (lbp), which is regulated upwards in gram-negative sepsis and related conditions. therefore, the aim of our study was to explore the diagnostic potential of lbp serum levels in well-defined, non-infectious and infectious events after kidney transplantation (ktx). in ... | 2002 | 11976738 |
| granulomatous pneumocystis carinii pneumonia in patients with malignancy. | a review was undertaken of the clinical features and results of diagnostic tests in non-hiv infected patients who developed granulomatous pneumocystis carinii pneumonia (pcp). | 2002 | 11978921 |
| pneumocystis carinii f. sp. hominis is not infectious for scid mice. | the infectious power of pneumocystis carinii f. sp. hominis was explored by inoculating scid mice intranasally with either p. carinii f. sp. hominis or p. carinii f. sp. muris isolates. only mice inoculated with mouse parasites developed pneumocystis pneumonia, as assessed by microscopy and pcr. these results suggest that humans do not contract pneumocystosis from animals. | 2002 | 11980979 |
| medical management of patients with brain tumors. | the most common medical problems in brain tumor patients involve the management of seizures, peritumoral edema, medication side effects, and venous thromboembolism. despite the importance of these issues, there are very few studies specifically addressing them. nonetheless, there has been some progress in recent years. there is increasing evidence that brain tumor patients who have not had a seizure do not benefit from prophylactic antiepileptic medications. patients taking corticosteroids are a ... | 2002 | 11981275 |
| cd25+cd4+ regulatory t cells suppress cd4+ t cell-mediated pulmonary hyperinflammation driven by pneumocystis carinii in immunodeficient mice. | the cd4(+) t cell-mediated inflammatory response to pneumocystis carinii (pc) critically contributes to the clinical severity of pc pneumonia. it has been suggested that lymphopenic conditions predispose individuals to this immunopathology, although the mechanisms remain poorly understood. another set of evidence indicates that a subpopulation of cd4(+) t cells constitutively expressing the cd25 molecule prevent lymphopenia-induced autoimmunity and inflammatory bowel disease. we tested the abili ... | 2002 | 11981815 |
| preservation of clonal heterogeneity of the pneumocystis carinii-specific cd4 t cell repertoire in hiv infected, asymptomatic individuals. | the loss of cd4 lymphocytes in hiv disease associates with opportunistic infections. since diverse cd4 t cell clones respond to an opportunistic pathogen, we asked whether cd4 depletion deletes selected clones in the repertoire (vertical depletion) or it affects all clones by reducing the cell number in each progeny without affecting the overall number of clones (horizontal depletion). understanding this point may help explain the mode of cd4 depletion and the mode of immunoreconstitution after ... | 2002 | 11982603 |
| infectious disease prophylaxis in renal transplant patients: a survey of us transplant centers. | definitive approaches to most infectious diseases following renal transplantation have not been established, leading to different approaches at different transplant centers. to study the extent of these differences, we conducted a survey of the practices surrounding specific infectious diseases at us renal transplant centers. a survey containing 103 questions covering viral, bacterial, mycobacterial and protozoal infections was developed. surveys were sent to program directors at all u.s. renal ... | 2002 | 11982608 |
| [opportunistic infections in hiv-positive patients hospitalized in the clinic of infectious diseases amg]. | opportunistic infections are one of the major problem among hiv infected patients still connected with high mortality. the aim of the investigation is to evaluate the incidence and mortality from opportunistic infections in hiv infected population in pomeranian region of poland. the paper presents analysis of incidence of opportunistic infections among 141 aids patients hospitalised in clinic for infectious diseases in gdańsk from 1988 to 2001/june/. in examined group 179 opportunistic infection ... | 2001 | 11984938 |
| [the essence of infection by opportunistic microorganisms]. | infection is regarded as an imbalance between microbial pathogenicity factors and the host defense systems. opportunistic infections are defined as infections rarely observed in humans with normal immune responses. the term immunocompromised (compromised) host refers to host in which one or more defence mechanisms are inactive and in which the probability of infection is therefore increased. hospital patients are often compromised host. compromised hosts exist even outside the hospital (smoking, ... | 2001 | 11984968 |
| [in vitro study of the anti-pneumocystis carinii effect of arteminsin derivatives]. | in vitro study was carried out to assess the effect of dihydroarteminsinin (dha) and sodium artesunate (ats) on pneumocystis carinii (pc). | 2001 | 11802960 |
| pneumocystis carinii pneumonitis in haemophagocytic lymphohistiocytosis. | we report on a 10-y-old boy who developed pneumocystis carinii pneumonitis (pcp) as the dominant symptom at the onset of haemophagocytic lymphohistiocytosis (hlh). pcp is a common infection in patients with combined primary immunodeficiencies or acquired immunodeficiency syndrome but it has rarely been observed at the onset of hlh. typically, hlh presents as a febrile syndrome associated with cytopenia and hepatosplenomegaly. repeated bone marrow aspirates, spleen or lymph node biopsies are some ... | 2001 | 11853350 |
| [pulmonary involvement due to disseminated non hodgkin lymphoma in one patient with aids]. | pulmonary involvement due to disseminated non hodgkin lymphoma (lnh), is an unusual cause of lung disease in aids patients. we report a 38 years old male patient, with advanced aids, who, in the course of three weeks, developed cough, dyspnea and fever. the chest x ray film showed diffuse thickening of the peribronchovascular connective tissue with possible mediastinal lymph node enlargement. the evolution was unfavorable with hypoxemia, severe anemia, liver damage and elevated levels of lactic ... | 2001 | 11836885 |
| induced sputum as a diagnostic specimen for pneumocystis carinii pneumonia in hiv positive patients. | 2001 | 11837488 | |
| plasminogen-binding activity of enolase in the opportunistic pathogen pneumocystis carinii. | the glycolytic enzyme enolase is one of the most abundant proteins expressed in fungi and has been shown to be an immunodominant cell-wall-associated antigen of the pathogenic fungus, candida albicans. enolase has also been found on the surface of some mammalian cells where it functions as a plasminogen-binding motif and facilitator of plasminogen activation to plasmin. to investigate the immunogenicity of enolase in the opportunistic pathogen, pneumocystis carinii, the genomic and complementary ... | 2001 | 11798055 |
| transplantation of highly purified cd34+thy-1+ hematopoietic stem cells in patients with recurrent indolent non-hodgkin's lymphoma. | to evaluate the results of high-dose chemotherapy and transplantation of highly purified "mobilized" peripheral blood cd34+thy-1+ hematopoietic stem cells (hscs) in patients with recurrent indolent non-hodgkin's lymphoma (nhl) or mantle cell lymphoma (mcl). | 2001 | 11787531 |
| pneumocystis carinii infection in red-bellied tamarins and cynomolgus monkeys, and the characterization of the mitochondrial large subunit ribosomal rna gene of pneumocystis carinii. | 2001 | 11906012 | |
| three new karyotype forms of pneumocystis carinii f. sp. carinii identified by contoured clamped homogeneous electrical field (chef) electrophoresis. | 2001 | 11906013 | |
| spatial analysis on the occurrence of pneumocystis carinii in the shrew notiosorex crawfordi in fragmented landscape in southern california. | 2001 | 11906015 | |
| parallel phylogenies of pneumocystis species and their mammalian hosts. | the single name pneumocystis carinii consists of an heterogeneous group of specific fungal organisms that colonize a very wide range of mammalian hosts. in the present study, mitochondrial large subunit (mtlsu) and small subunit (mtssu) rrna sequences of p. carinii organisms from 24 different mammalian species were compared. the mammals were included in six major groups: primates (12 species), rodents (5 species), carnivores (3 species), bats (1 species), lagomorphs (1 species), marsupials (1 sp ... | 2001 | 11906016 |
| cloning and sequence analysis of translational release factors erf1 and erf3 of pneumocystis carinii. | 2001 | 11906017 | |
| detailed structure of pneumocystis carinii chromosome ends. | 2001 | 11906018 | |
| typing of pneumocystis carinii f.sp. hominis isolates from nasopharyngeal aspirates of immunocompetent infants with bronchiolitis by dihydropteroate synthase gene analysis. | 2001 | 11906019 | |
| pneumocystis carinii detection using nested-pcr in nasopharyngeal aspirates of immunocompetent infants with bronchiolitis. | 2001 | 11906020 | |
| typing of pneumocystis carinii f.sp. hominis in patients with or without pneumocystosis. | 2001 | 11906021 | |
| stimulation of pneumocystis carinii encystment following necropsy. | 2001 | 11906024 | |
| a gene complex mediating cyst wall assembly and integrity in pneumocystis carinii. | 2001 | 11906025 | |
| synaptonemal complexes in the pre-cyst of pneumocystis carinii. | 2001 | 11906026 | |
| early acquisition of pneumocystis carinii in neonatal rats using targeted pcr and oral swabs. | 2001 | 11906027 | |
| pneumocystis carinii dihydropteroate synthase genotypes in hiv-infected persons residing in san francisco: possible implications for disease transmission. | 2001 | 11906028 | |
| putative transmissive form of pneumocystis carinii f. sp. carinii. | 2001 | 11906029 | |
| analysis of a pheromone receptor and map kinase suggest a sexual replicative cycle in pneumocystis carinii. | 2001 | 11906031 | |
| definitive structural identities of 42 sterol components in pneumocystis carinii. | 2001 | 11906032 | |
| pneumocystis carinii erg6 gene: sequencing and expression of recombinant sam:sterol methyltransferase in heterologous systems. | 2001 | 11906033 | |
| pneumocystis carinii its typing: doubtful evidence of genotype-related virulence. | 2001 | 11906034 | |
| pcr-rflp analysis of the dhps gene for the study of resistance of pneumocystis carinii to sulpha drugs in patients with co-infection pcp/hiv. | 2001 | 11906035 | |
| urokinase plasminogen activator and tgf-beta production in immunosuppressed patients with and without pneumocystis carinii. | 2001 | 11906036 | |
| recombinant cd40 ligand administration does not decrease intensity of pneumocystis carinii infection in scid mice. | x-linked hyper igm syndrome (him) is a rare congenital immunodeficiency recently demonstrated to be caused by a mutation in the gene encoding cd40 ligand. these patients are susceptible to pneumocystis carinii pneumonia, which implies an important role for cd40l in host defense against p. carinii. in this study we undertook to investigate whether treatment of p. carinii infected scid mice with murine recombinant cd40 ligand trimer (mucd40l) for 21 days would facilitate clearance of the organisms ... | 2001 | 11906038 |
| mechanisms of amino acid and glucose uptake by pneumocystis carinii. | 2001 | 11906039 | |
| pneumocystis carinii beta-glucan induces release of macrophage inflammatory protein-2 from primary rat alveolar epithelial cells via a receptor distinct from cd11b/cd18. | 2001 | 11906040 | |
| effect of the transcription factor gata-2 on phagocytic activity of alveolar macrophages from pneumocystis carinii-infected hosts. | 2001 | 11906041 | |
| changes in alveolar macrophage number are early events in pneumocystis carinii infection. | 2001 | 11906044 | |
| bronchoalveolar lavage fluid from pneumocystis carinii-infected rats inhibits phagocytosis in normal alveolar macrophages. | 2001 | 11906045 | |
| production and role of nitric oxide in the alveolar immune response to pneumocystis carinii. | 2001 | 11906046 | |
| pneumocystis carinii does not induce maturation of human dendritic cells. | 2001 | 11906047 | |
| pneumocystis carinii synthesizes four ubiquinone homologs: inhibition by atovaquone and bupravaquone but not by stigmatellin. | 2001 | 11906049 | |
| toward rational design of species-specific inhibitors of pneumocystis carinii thymidylate synthase and toxoplasma gondii dihydrofolate reductase-thymidylate synthase. | 2001 | 11906050 | |
| development of an rt-pcr on the heat shock protein 70 gene for viability detection of pneumocystis carinii f. sp. hominis in patients with pneumocystosis and in air sample. | to test the viability of pneumocystis carinii f. sp. hominis, an rt-pcr assay that employs specific primers from the heat shock protein 70 gene was developed. using this method, the viability of p.c. hominis in bronchoalveolar lavage fluids from patients developing pcp and in the environment of pcp patients was established. | 2001 | 11906051 |
| standardization of an in vitro drug screening assay by use of cryopreserved and characterized pneumocystis carinii populations. | 2001 | 11906052 | |
| pneumocystis carinii dihydropteroate synthase mutations and treatment with sulfa or sulfone regimens: a proposal for standardized definitions for clinical evaluation. | 2001 | 11906054 | |
| pneumocystis carinii granuloma of the optic nerve: a histopathologic case report. | a 30-year-old man under treatment for acute leukemia died of candida sepsis and pneumocystis carinii pneumonia. a small granuloma containing pneumocystis carinii was found in one optic nerve. | 2001 | 11756858 |
| pneumocystis carinii pneumonia in systemic lupus erythematosus: a report of two cases. | patients with systemic lupus erythematosus (sle) have increased susceptibility to infection by pneumocystis carinii, but this condition has rarely been reported in taiwan. here, we describe two cases of patients with sle who developed pneumocystis carinii pneumonia (pcp). the first patient was a 39-year-old woman presenting with fever and dyspnea that had lasted 2 weeks. chest roentgenography disclosed bilateral interstitial and alveolar infiltrates. the second patient was a 22-year-old woman pr ... | 2001 | 11760377 |
| [primary immunodeficiency secondary to zap-70 deficiency]. | the authors present the case of a child with recurrent infections since the age of 4 months, including bilateral pneumonia by pneumocystis carinii and protracted varicella. serum immunoglobulin values (when 10 months old), and b cell values were normal. there was persistent lymphocytic leucocytosis, near absence of cd8+ cells, and an increased cd4/cd8 ratio. the percentage of activated t cells and the expression of hla class i were normal. proliferation, activation and il-2 synthesis studies in ... | 2001 | 11762183 |
| fludarabine and mitoxantrone: effective and well-tolerated salvage therapy in relapsed indolent lymphoproliferative disorders. | prior studies of the combination of fludarabine, mitoxantrone and dexamethasone have yielded high response rates but are associated with a significant risk of opportunistic infections, predominantly pneumocystis carinii pneumonia (pcp) requiring routine prophylaxis. | 2001 | 11762819 |
| [pneumothorax in patients infected by the human immunodeficiency virus]. | patients with hiv who develop pneumothorax have been previously described. pneumocystis carinii pneumonia (pcn) is the leading cause of this complication, but infection by other pulmonary microorganism, inhaled pentamidine therapy and lung invasive manoeuvres have also been associated with pneumothorax in hiv infected patients. | 2001 | 11766281 |
| antibacterial prophylaxis with trimethoprim-sulfamethoxazole during induction treatment for acute lymphoblastic leukemia. | children with acute lymphoblastic leukemia are treated with intensive chemotherapy resulting in profound immuno suppression. therefore treatment with trimethoprim-sulfamethoxazole (tmp-smx) may be used for prophylaxis against infections both with bacteria and pneumocystis carinii in some departments. the use of tmp-smx for prophylaxis during the induction therapy is not uniform in the four departments of pediatric oncology in denmark. this gave us the opportunity to describe the effect of tmp/sm ... | 2001 | 11767129 |
| pulmonary manifestations of hiv infection in the era of highly active antiretroviral therapy. | to determine whether the spectrum of hiv-related pulmonary disease seen by a university medical center pulmonary and critical care medicine service has changed since the introduction of highly active antiretroviral therapy (haart). | 2001 | 11742918 |
| germ cell tumors in patients infected by the human immunodeficiency virus. | the objective of this study was to assess the natural history of the two disease courses, patient immune system tolerance, and results of therapy in human immunodeficiency virus (hiv)-infected patients with germ cell tumors (gct). | 2001 | 11745223 |
| flexible bronchoscopy in the diagnosis of pulmonary infiltrates following autologous peripheral stem cell transplantation for advanced breast cancer. | flexible bronchoscopy is an important tool in the diagnosis of pulmonary complications following bone marrow transplantation. however, the value of this procedure in autologous peripheral stem cell transplant (apsct) recipients with pulmonary complications is not well defined. we retrospectively evaluated the diagnostic yield of 27 consecutive bronchoscopies done on 23 apsct recipients following high-dose chemotherapy for breast cancer. fb resulted in a positive diagnosis in 16 cases (59%). bron ... | 2001 | 11753555 |
| a randomized, double-blind, placebo-controlled study of itraconazole capsules for the prevention of deep fungal infections in immunodeficient patients with hiv infection. | to determine whether systemic or deep fungal infections can be prevented, a double-blind, placebo-controlled, phase iii trial of itraconazole prophylaxis was undertaken in hiv-infected patients. | 2001 | 11737382 |
| pneumocystis carinii pneumonia: a review of current issues in diagnosis and management. | 2001 | 11737389 | |
| pulmonary pathology in patients with aids: an autopsy study from mumbai. | although india has a high prevalence of hiv/aids, the associated pathologies responsible for morbidity have not been evaluated previously in a representative study. hence, an autopsy study was carried out to analyse the spectrum of pulmonary lesions in patients with hiv/aids. | 2001 | 11737408 |
| mutations in dihydropteroate synthase gene of pneumocystis carinii in hiv patients with pneumocystis carinii pneumonia. | the purpose of this study was to determine whether dihydropteroate synthase gene (dhps) mutations were associated with the failure of sulpha/sulphone drugs used as prophylaxis agents in hiv infected patients. results suggested that dhps mutations were significantly associated with failure of anti-pneumocystis carinii sulphone prophylaxis (p=0.031). an increasing number of mutant p. carinii strains have been isolated from patients no longer having prophylaxis. there was no statistically significa ... | 2001 | 11738342 |
| use of real-time pcr and the lightcycler system for the rapid detection of pneumocystis carinii in respiratory specimens. | pneumocystis carinii pneumonia (pcp) remains a major cause of morbidity and mortality in immunocompromised patients, including those infected with human immunodeficiency virus (hiv). the advent of real-time pcr technology offers the potential for rapid pcr results for the detection of p. carinii. in this report we describe the modification and evaluation of an existing pcr-based method for the detection of p. carinii dna, into a real-time pcr assay suitable for use with the lightcycler system. t ... | 2001 | 11404066 |
| pulmonary infiltrates in hiv-infected patients in the highly active antiretroviral therapy era in spain. | to study the incidence, etiology, and outcome of pulmonary infiltrates (pis) in hiv-infected patients and to evaluate the yield of diagnostic procedures. | 2001 | 11404518 |
| incidence and determinants of bacterial infections in hiv-positive patients receiving anti-pneumocystis carinii/toxoplasma gondii primary prophylaxis within a randomized clinical trial. | we assessed the incidence and determinants of bacteremia, pneumonia, and sinusitis/otitis in hiv-positive people receiving cotrimoxazole (ctx) or dapsone-pyrimethamine (dp) for primary prophylaxis of pneumocystis carinii pneumonia (pcp) and toxoplasmic encephalitis (te) within a randomized clinical trial. in total, 244 patients were randomized: 122 were assigned to ctx and 122 to dp. in the cohort, 22 bacteremia, 63 pneumonia, and 39 sinusitis/otitis cases were observed. incidence rates of bacte ... | 2001 | 11404520 |
| trimethoprim/sulfamethoxazole-induced toxic epidermal necrolysis. | to report a case of toxic epidermal necrolysis (ten) associated with trimethoprim/sulfamethoxazole (tmp/smx). | 2001 | 11408987 |
| [pneumonia in patients with chronic lymphocytic leukemia. study of 30 episodes]. | to analyse the etiology, diagnostic methods and response to therapy in 30 episodes of pneumonia diagnosed in 17 patients with chronic lymphocytic leukemia (cll) between 1995 and 2000. | 2001 | 11412696 |
| uptake of the neutral amino acids glutamine, leucine, and serine by pneumocystis carinii. | experiments to elucidate the mechanism by which pneumocystis carinii transports glutamine, leucine, and serine were performed in this study. uptake of all three radiolabeled amino acids exhibited first-order, saturation kinetics as extracellular substrate concentrations were increased, thus ruling out simple diffusion and indicating carrier-mediated transport. kinetic analyses of amino acid uptake and the results of competitive inhibition experiments suggested that leucine, serine, and glutamine ... | 2001 | 11414689 |
| initiating co-trimoxazole prophylaxis in hiv-infected patients in africa: an evaluation of the provisional who/unaids recommendations. | to evaluate the proposed who/unaids criteria for initiating co-trimoxazole prophylaxis in adult hiv-infected patients in africa [who clinical stages 2--4 or cd4 count < 500 x 10(6) /l or total lymphocyte count (tlc) equivalent]. | 2001 | 11416716 |
| summary of the guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. | this article contains highlights of "guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients: recommendations of the cdc, the infectious diseases society of america, and the american society of blood and marrow transplantation," which was published in the morbidity and mortality weekly report. there are sections on the prevention of bacterial, viral, fungal, protozoal, and helminth infections and on hospital infection control, strategies for safe li ... | 2001 | 11418871 |
| [respiratory infections during chemotherapy-induced aplasia]. | damage to local and systemic host defenses of the lung makes the immunocompromised patient vulnerable to inhaled microorganisms. when a pulmonary infiltrate occurs, the array of possibilities is very large including conventional and opportunistic agents. the type of underlying disease and its associated immunodeficiency allow a high degree of accurate pathogen prediction. neutropenia is associated with gram-negative bacilli pneumonia. prolonged neutropenia increases the risk of invasive aspergil ... | 2001 | 11424709 |
| a meta-analysis of salvage therapy for pneumocystis carinii pneumonia. | to determine the relative efficacies of alternative antipneumocystis agents in human immunodeficiency virus (hiv)-infected patients with pneumocystis carinii pneumonia unresponsive to primary drug treatment with a combination product of trimethoprim and sulfamethoxazole or parenteral pentamidine. | 2001 | 11427101 |
| pneumocystis carinii carriage among cystic fibrosis patients, as detected by nested pcr. | a total of 137 sputa from 95 consecutive cystic fibrosis (cf) patients undergoing routine bacteriological surveillance were analyzed for pneumocystis carinii colonization using nested pcr. seven of 95 patients (7.4%) were pcr positive, suggesting that p. carinii carriage may exist among cf patients due to their underlying pulmonary disease. | 2001 | 11427604 |