Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| epidemiology and genotype distribution of human papillomavirus (hpv) in women of sardinia (italy). | the human papillomavirus (hpv) infection is necessary for the development of cervical cancer. our study aims to evaluate the rate of hpv circulation in our population, to identify the prevalent genotypes and to establish correlation with cervical abnormalities. furthermore, the awareness of women about hpv issues was investigated. this study included 864 women attending the oncologic prevention service for their routine pap test screening or the health promotion mother-child service for counsell ... | 2009 | 19480954 |
| human papillomavirus genotypes and phylogenetic analysis of hpv-16 variants in hiv-1 infected subjects in italy. | a cross-sectional study was carried out to improve the state of evidence regarding the spectrum of hpv types and hpv-16 lcr variants circulating among men and women infected with hiv-1 in italy. this study, conducted in 518 hiv-positive subjects (346 males and 172 females), showed a high prevalence of hpv anal infections (88.7%) in men and of cervical infections (65.1%) in women. a wide spectrum of hpv genotypes has been observed, as both single and multiple infections. low-risk hpv types 6, 11 ... | 2009 | 19480955 |
| anal hpv genotypes and related displasic lesions in italian and foreign born high-risk males. | anal intraepithelial neoplasia and anal cancer are closely related to infection from high-risk human papilloma virus (hpv) genotypes. since hpvs involved in disease progression are reported to vary by geographical regions, this study focuses on hpv genotypes spectrum in 289 males attending a sexual transmitted diseases (std) unit according to their nationality. anal cytology, digene hybrid capture assay (hc2) and hpv genotyping were evaluated in 226 italian (it) and 63 foreign born (fb) subjects ... | 2009 | 19480957 |
| distribution of human papillomavirus genotypes in invasive cervical cancer in italy: a representative, single institution case series. | despite worldwide human papillomavirus (hpv) types distribution showed constant rates of hpv 16/18 in cervical cancers, regional variations have been consistently documented. very little data is available on hpv genotype prevalence among italian women with invasive cervical cancer. this study aims to determine the hpv type distribution in cervical specimens obtained from italian women diagnosed with invasive cervical cancer and referred to the european institute of oncology (ieo). two hundred-si ... | 2009 | 19480958 |
| radiation response in two hpv-infected head-and-neck cancer cell lines in comparison to a non-hpv-infected cell line and relationship to signaling through akt. | human papilloma virus (hpv)-associated cancers of the head and neck (h&n) are increasing in frequency and are often treated with radiation. there are conflicting data in the literature regarding the radiation response in the presence of hpv infection, with some data suggesting they may be more sensitive to radiation. there are few studies looking at in vitro effects of hpv and further sensitization by inhibitors of specific signaling pathways. we are in the process of starting a clinical trial i ... | 2009 | 19480971 |
| treatment with demethylating agent, 5-aza-2'-deoxycytidine enhances therapeutic hpv dna vaccine potency. | dna vaccines have emerged as a potential alternative to current strategies to control cancer for their safety, stability and ease of preparation. we have previously demonstrated that a dna vaccine encoding calreticulin (crt) linked to human papillomavirus type 16 (hpv-16) e7 antigen (crt/e7) can generate significant e7-specific immune responses and antitumor effects in vaccinated mice, thus enhancing dna vaccine potency. another strategy to improve dna vaccine potency is by enhancing the level o ... | 2009 | 19481843 |
| mothers' intention for their daughters and themselves to receive the human papillomavirus vaccine: a national study of nurses. | the aims of this study were to examine mothers' intention to vaccinate their daughters and themselves against human papillomavirus and to determine which demographic, behavioral, and attitudinal factors were associated with intention to vaccinate daughters. | 2009 | 19482752 |
| a standardized framework for accurate, high-throughput genotyping of recombinant and non-recombinant viral sequences. | human immunodeficiency virus type-1 (hiv-1), hepatitis b and c and other rapidly evolving viruses are characterized by extremely high levels of genetic diversity. to facilitate diagnosis and the development of prevention and treatment strategies that efficiently target the diversity of these viruses, and other pathogens such as human t-lymphotropic virus type-1 (htlv-1), human herpes virus type-8 (hhv8) and human papillomavirus (hpv), we developed a rapid high-throughput-genotyping system. the m ... | 2009 | 19483099 |
| glassy cell carcinoma predominantly commits to a squamous lineage and is strongly associated with high-risk type human papillomavirus infection. | summary: glassy cell carcinoma (gcc) has been believed to have originated from reserve or uncommitted cells as a poorly differentiated adenosquamous carcinoma. this study includes immunoprofiles of p63, cytokeratin 17 (ck17), and cd44 to clarify which lineage of gcc is committed to human papillomavirus (hpv) detection, and to verify whether or not hpv plays a role in gcc. nine uterine gccs showing overwhelmingly glassy features were evaluated by an hpv genotyping chip and by immunohistochemistry ... | 2009 | 19483622 |
| genomic profiling identifies common hpv-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck. | it is well known that a persistent infection with high-risk human papillomavirus (hrhpv) is causally involved in the development of squamous cell carcinomas of the uterine cervix (cxsccs) and a subset of sccs of the head and neck (hnsccs). the latter differ from hrhpv-negative hnsccs at the clinical and molecular level. | 2009 | 19486517 |
| parents' views on 3 shot-related visits: implications for use of adolescent vaccines like human papillomavirus vaccine. | multidose adolescent-targeted vaccines, for example the human papillomavirus (hpv) vaccine, require parents and adolescents to have repeated interactions with the physician's office. we sought to evaluate parental views on participating in frequent vaccine-related encounters and their preferences for how these encounters should ideally be implemented. | 2009 | 19487172 |
| human papillomavirus in early laryngeal carcinoma. | to examine the role of hpv status in the etiology, prognosis, and treatment of head and neck squamous cell carcinoma in early larynx malignancies. | 2009 | 19489068 |
| age-based programs for vaccination against hpv. | the risk of infection with human papillomavirus (hpv) increases with age. answering the question of which age groups are appropriate to target for catch-up vaccination with the newly licensed quadrivalent hpv vaccine (types 6/11/16/18) will be important for developing vaccine policy recommendations. | 2009 | 19490561 |
| human papillomavirus genotype specificity of hybrid capture 2 low-risk probe cocktail. | a genotyping study of 285 hybrid capture 2 low-risk probe cocktail-positive specimens showed cross-reactivity with several untargeted human papillomavirus genotypes. cross-reactivity was often clinically beneficial due to the detection of untargeted low-risk genotypes. a total of 8.4% of positive results, usually weak, were due to cross-reactivity with high-risk genotypes. establishment of a gray zone is recommended. | 2009 | 19494080 |
| laser capture microdissection of cervical human papillomavirus infections: copy number of the virus in cancerous and normal tissue and heterogeneous dna methylation. | research on the pathogenicity of human papillomaviruses (hpvs) during cervical carcinogenesis often relies on the study of homogenized tissue or cultured cells. this approach does not detect molecular heterogeneities within the infected tissue. it is desirable to understand molecular properties in specific histological contexts. we asked whether laser capture microdissection (lcm) of archival cervical tumors in combination with real-time polymerase chain reaction and bisulfite sequencing permits ... | 2009 | 19497607 |
| infectious disease: male circumcision for preventing hpv infection. | the role of male circumcision in reducing sexually transmitted infections is controversial. a series of recently published papers add to the growing body of evidence that male circumcision might reduce carriage of penile human papillomavirus (hpv). | 2009 | 19498404 |
| staurosporine induces apoptosis in human papillomavirus positive oral cancer cells at g2/m phase by disrupting mitochondrial membrane potential and modulation of cell cytoskeleton. | our study demonstrates that staurosporine (sts), a protein kinase inhibitor from streptomyces sp., induces apoptosis in human papillomavirus positive oral carcinoma cells (kb) in a dose dependent manner. growth inhibition studies revealed an ic(50) value of approximately 100 nm. sts induced marked nuclear fragmentation and inter-nucleosomal cleavage compared to untreated cells. it also caused dose dependent disruption of mitochondrial membrane potential and activation of caspase-3, indicating in ... | 2009 | 19502099 |
| hpv infection and p53 inactivation in pterygium. | our recent report indicated that tumor suppressor gene (p53) mutations and protein aberrant expression were detected in pterygium. inactivation of p53 by human papillomavirus (hpv) 16/18 e6 plays a crucial role in cervical tumorigenesis. in this study, we further speculate that p53 inactivation may be linked with hpv infection in pterygium pathogenesis. to investigate the involvement of hpv 16/18 e6 in p53 inactivation in pterygium, the association between hpv 16 or hpv 18 infection, the hpv e6 ... | 2009 | 19503739 |
| impact of human papillomavirus vaccination depends on effective vaccination strategy. | 2009 | 19507251 | |
| cell-mediated immune responses to human papillomavirus 16 e6 and e7 antigens as measured by interferon gamma enzyme-linked immunospot in women with cleared or persistent human papillomavirus infection. | cell-mediated immune responses have been thought to be important in the control of human papillomavirus (hpv) infections. we examined cell-mediated immune responses to hpv-16 e6 and e7 in the peripheral blood using interferon gamma (ifn-gamma) enzyme-linked immunospot assay (cellular technology ltd, cleveland, ohio) in women with hpv-16 infection who showed clearance and compared these women to women with hpv-16 persistence. women participating in a longitudinal study of cervical hpv were recrui ... | 2009 | 19509544 |
| patients with usual vulvar intraepithelial neoplasia-related vulvar cancer have an increased risk of cervical abnormalities. | vulvar squamous cell carcinoma (scc) originates the following two pathways, related to differentiated (d) vulvar intraepithelial neoplasia (vin) or to human papillomavirus (hpv)-related usual (u) vin. multicentric hpv infections (cervix, vagina and vulva) are common. we hypothesise that patients with a uvin-related vulvar scc more often have cervical high-grade squamous intraepithelial lesions (hsils) compared with women with dvin-related vulvar scc. | 2009 | 19513077 |
| adsorption of human papillomavirus 16 to live human sperm. | human papillomaviruses (hpvs) are a diverse group of viruses that infect the skin and mucosal tissues of humans. a high-risk subgroup of hpvs is associated with virtually all cases of cervical cancer [1]-[3]. high-risk hpvs are transmitted sexually; however, the exact mechanisms by which sexual contact promotes virus infection remain uncertain. to study this question we asked whether capsids of hpv type 16 (a high-risk hpv) specifically interact with sperm cells. we tested if purified hpv16 viri ... | 2009 | 19513123 |
| [detection of oncoprotein e7 hpv16 in the cancer and normal urinary bladder urothelium]. | oncoprotein e7 hpv16 was detected by immunohistochemical staining with specific polyclonal antiserum [fiedler et al., 2004] in 7 out of the 24 (29.2%) studied bladder cancer specimens. the result is in good agreement with the hypothesis that hpvs take part in the carcinogenesis of the urothelium. however, some of the observations made seem rather hard to be interpreted at present. the latter include the detection of e7 hpv16 in a small number of cancer cells in a few bladder cancer specimens bei ... | 2009 | 19514355 |
| cutaneotropic human beta-/gamma-papillomaviruses are rarely shared between family members. | several cutaneotropic human papillomavirus (hpv) types seem to be involved in the early onset of cutaneous squamous-cell carcinoma. to test the hypothesis that cutaneotropic hpv infections are facilitated because of close and frequent skin contact (for example, between child and mother), we examined hpv prevalence in hair follicle cells from 134 volunteers (1-89 years of age, median 42 years) from 13 families. we used a high-throughput hpv-typing approach with a sensitive beta-/gamma-cutaneous p ... | 2009 | 19516265 |
| hpv 16 e2 protein induces apoptosis in human and murine hpv 16 transformed epithelial cells and has antitumoral effects in vivo. | our aims were to examine the ability of the human papillomaviruse (hpv) 16 e2 protein to induce apoptosis in a murine hpv-transformed cell line, and to evaluate its antitumor properties on hpv-associated tumors in vivo in immunocompetent mice. | 2009 | 19390235 |
| human papilloma virus dna detection, p53 and ki67 expression in penile verrucous and squamous cell carcinomas in the same patient. | 2009 | 19390495 | |
| fdg-pet/ct: new horizons in anal cancer. | anal cancer is an uncommon tumor with an incidence of about one case per 100,000 in most countries. its incidence seems to be increasing because of exposure to human immunodeficiency virus (hiv) and human papillomavirus (hpv). traditional pretreatment evaluations include physical examination and ct imaging of the pelvis. current treatment guidelines include fluorodeoxyglucose positron emission tomography integrated with computed tomography (fdg-pet/ct) as part of the standard pretreatment workup ... | 2009 | 19394179 |
| comparison of the papillocheck dna micro-array human papillomavirus detection assay with hybrid capture ii and pcr-enzyme immunoassay using the gp5/6+ primer set. | cervical screening detects precancerous cells and routine screening could be improved by testing for human papillomavirus (hpv), the virus that causes cervical cancer. hpv infection is common and the benefit of hpv testing would be identification of women who are hpv negative and at low risk of developing cancer. | 2009 | 19394266 |
| understanding the reasons why mothers do or do not have their adolescent daughters vaccinated against human papillomavirus. | the objective of this study was to compare the reasons why mothers do or do not have their adolescent daughters vaccinated against hpv. | 2009 | 19394865 |
| at what age should cervical screening stop? | 2009 | 19395422 | |
| human papillomavirus, abstinence, and the other risks. | 2009 | 19400001 | |
| rna (e6 and e7) assays versus dna (e6 and e7) assays for risk evaluation for women infected with human papillomavirus. | in the majority of cases, high-risk human papillomavirus (hr hpv) infections regress spontaneously, with only a small percentage progressing to high-grade lesions. current screening methods are based on dna detection. an alternative would be to monitor expression of the e6 and e7 viral oncogenes continuously expressed by malignant phenotypes. in the work reported in this paper, we compared the two methods for a group of women with high-risk hpv infections. cervical specimens from 400 women, prev ... | 2009 | 19403762 |
| human papillomavirus and head and neck squamous cell carcinoma: recent evidence and clinical implications. | over the past 20 years, high-risk human papilloma-virus (hpv) infection has been established as a risk factor for developing head and neck squamous cell carcinoma, independent of tobacco and alcohol use. in particular, hpv is strongly associated with the development of oropharyngeal cancer and a small minority of oral cavity cancers. in this review, we summarize what is currently known about the biology of hpv, the mechanisms by which it effects malignant transformation, and the potential impact ... | 2009 | 19407148 |
| cervical cancer screening among college students in ghana: knowledge and health beliefs. | cervical cancer is the most incident cancer and the leading cause of cancer mortality in women in ghana. currently, little is known about ghanaian women's knowledge and beliefs about cervical cancer screening, yet this information is essential to the success of cervical cancer screening programs. therefore, the purpose of this study was to describe the knowledge and beliefs of female university college students in ghana. | 2009 | 19407569 |
| hla-g polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus. | human papillomavirus (hpv) infection is etiologically associated with low- (lsil) and high-grade squamous intraepithelial lesions (hsil) and with cervical cancer. the progression or regression of the lesions may depend, among other factors, on the host heritable immune response. because human leukocyte antigen (hla)-g molecules are involved in the modulation of innate and adaptive immune responses, and because no previous studies have evaluated hla-g polymorphism in patients with sil, we conduct ... | 2009 | 19407850 |
| enhanced papillomavirus-like particle production in insect cells. | human papillomavirus (hpv) l1 self-assembles into virus-like particles (vlps), which are the basis for the two commercially available prophylactic vaccines. for one of them (cervarix) hpv 16 and 18 vlps are being produced in insect cells using the baculovirus expression system. however, due to low yield, production of vlps remains challenging for certain other pv types. here we report that employment of a modified baculovirus-based (multibac) expression system (berger, i., fitzgerald, d. j., and ... | 2009 | 19409593 |
| development and evaluation of a pcr and mass spectroscopy (pcr-ms)-based method for quantitative, type-specific detection of human papillomavirus. | knowledge of the central role of high-risk human papillomavirus (hpv) in cervical carcinogenesis, coupled with an emerging need to monitor the efficacy of newly introduced hpv vaccines, warrant development and evaluation of type-specific, quantitative hpv detection methods. in the present study, a prototype pcr and mass spectroscopy (pcr-ms)-based method to detect and quantitate 13 high-risk hpv types is compared to the hybrid capture 2 high-risk hpv dna test (hc2; digene corp., gaithersburg, md ... | 2009 | 19410602 |
| conjunctival papilloma. | 2009 | 19410961 | |
| role of e6/e7 onco-proteins of high-risk human papillomaviruses in human colorectal carcinogenesis. | 2009 | 19411835 | |
| entire genome characterization of human papillomavirus type 16 from infected thai women with different cytological findings. | global prevalence of human papillomavirus type 16 (hpv16) exceeds that of other types. this project has been aimed at attaining basic molecular knowledge of hpv16 by sequencing the whole genome of hpv16 isolated from thai women at various clinical stages of disease progression. our group analyzed seven samples of hpv16 in infected women ranging from normal to cervical cancer and discovered two critical non-synonymous changes within the coding region converting the e2-219p prototype to e2-219t in ... | 2009 | 19412733 |
| the genomics of oral cancer and wound healing. | oral cancer is the most common malignancy in india, where it is epidemiologically linked to the chewing of betel quid and other carcinogens. but various point mutations were detectable in the p53 and p15 genes. hence, this review was conducted with the aim to find out genetic risks as well as markers for oral cancers and wound healing. tobacco-related cancers are associated with polymorphisms of the cyp1a1 and gstm1 genes in terms of genotype frequencies and cigarette smoking dose. expression of ... | 2009 | 19414966 |
| epidemiology of cutaneous human papillomavirus infections. | 2009 | 19415200 | |
| statement on human papillomavirus dna test utilization. | 2009 | 19415756 | |
| current concepts in cervical pathology. | the correct diagnosis and reporting of cervical in situ and invasive carcinoma are essential for the appropriate clinical management of patients with human papillomavirus-associated disease. | 2009 | 19415947 |
| lack of detection of human papillomavirus infection by hybridization test in prostatic biopsies. | to explore the possibility of finding human papillomavirus (hpv) infection in the prostate tissue of a cohort of saudi men presenting with benign prostatic hyperplasia (bph) or prostate cancer. | 2009 | 19417961 |
| correlation of hpv-16/18 infection of human papillomavirus with lung squamous cell carcinomas in western china. | prevalent inconsistency of human papillomavirus (hpv) infection in lung cancer was found among recent studies from different countries with racial and geographic variations. even in chinese populations, the prevalent discrepancy of hpv infection in lung cancer patients was also found with the geographic variations and tumor types. to study the difference of hpv-16/18 infection in lung squamous cell carcinomas and non-cancer controls, we conducted this study to verify whether there was a similar ... | 2009 | 19424646 |
| the anti-apoptotic role for p53 following exposure to ultraviolet light does not involve ddb2. | the p53 tumour suppressor is a transcription factor that can either activate or repress the expression of specific genes in response to cellular stresses such as exposure to ultraviolet light. the p53 protein can exert both pro- and anti-apoptotic effects depending on cellular context. in primary human fibroblasts, p53 protects cells from uv-induced apoptosis at moderate doses but this is greatly affected by the nucleotide excision repair (ner) capacity of the cells. the damage-specific dna bind ... | 2009 | 19428372 |
| human papillomavirus vaccine decision-making in da nang, vietnam: perceived spousal and adolescent-parent concordance. | this descriptive study examined parents' perceptions of the role of mothers, fathers, and daughters in the decision to have their daughter receive the human papillomavirus (hpv) vaccine; perceived concordance between spouses and between parents and daughters; and the relationships between vaccine decision-making and (1) who takes the daughter to the doctor, and (2) the daughter's age. health care workers (n=139) with a daughter 9-21 years old completed a self-administered questionnaire including ... | 2009 | 19428852 |
| comparison of three management strategies for patients with atypical squamous cells of undetermined significance, after six months delay: a three-year experience in an iranian university hospital. | a pap test result of atypical squamous cells of undetermined significance (ascus) presents a clinical challenge. only 5-10% of women with ascus harbour serious cervical disease. | 2009 | 19432613 |
| human papillomavirus infections among japanese women: age-related prevalence and type-specific risk for cervical cancer. | to obtain baseline data for human papillomavirus (hpv) screening and vaccination in japan, we analyzed hpv dna data from 2282 japanese women (1517 normal cytology, 318 cervical intraepithelial neoplasia [cin] grade 1, 307 cin2-3, and 140 invasive cervical cancer [icc]) that visited the university of tsukuba hospital or ibaraki seinan medical center hospital for screening or treatment of cervical diseases between 1999 and 2007. an l1-based pcr method was used for individual hpv genotyping. the mo ... | 2009 | 19432906 |
| the evolving definition of carcinogenic human papillomavirus. | thirteen human papillomavirus (hpv) genotypes have been judged to be carcinogenic or probably carcinogenic, and the cause of virtually all cervical cancer worldwide. other hpv genotypes could possibly be involved. although the inclusion of possibly carcinogenic hpv genotypes may hurt test specificity, it may indirectly increase the reassurance following a negative hpv test (i.e. the negative predictive value of an hpv test for cervical precancer and cancer). the future of cervical cancer screeni ... | 2009 | 19432962 |
| human papillomavirus infection and cervical cytology in hiv-infected and hiv-uninfected rwandan women. | data on human papillomavirus (hpv) prevalence are essential for developing cost-effective cervical cancer prevention programs. | 2009 | 19435429 |
| a 7.5-year prospective study of longer than 18 months type-specific human papillomavirus persistence in a routine cytology-based cervical screening population of about 31,000 women in west germany. | the objective of this study was to analyse the prevalence, infection pattern, duration and outcome of long-term, type-specific, persistent human papillomavirus (hpv) infections in a routine cytology-based cervical screening population of west german women followed up for 7.5 years. from a screening population of 31,000 women, a strictly selected cohort of 100 patients with > or =18-month persistent, type-specific hpv infection were prospectively followed up for a mean of 35.52 months (+/-13.0). ... | 2009 | 19436214 |
| [hpv caused pathological changes in genital system of mice]. | the recombined adenovirus dna was transfected into 293 cells for packing and amplification of replication-deficient ad-cmv-e6/e7, ad-k14 -e6/e7 virus was purified by cscl density gradient centrifugation , recombined adenovirus ad-cmv-e6/e7, ad-k14 -e6/e7 were used as experimental group, while pad-cmv and padtrack-k14 were used as control group. four of them were injected through one main vein of nude mice tail respectively. these mice were then treated with 0.05 mg 17beta-estradiol over 12 weeks ... | 2009 | 19437884 |
| prophylactic and therapeutic human papillomavirus vaccine: a breakthrough for women health. | human papilloma virus (hpv) associated cervical cancer is amongst the ten most common cancers in women in the developing world. new vaccines markedly reduce the economic burden of diseases on a country's health system. two types of hpv vaccines are available; prophylactic and therapeutic. prophylactic vaccines target (late protein) l1 and to a lesser extent l2, which stimulate neutralizing antibody response and are recommended to individuals prior to infection. therapeutic vaccines are recommend ... | 2009 | 19438137 |
| safety and preliminary efficacy data of a novel casein kinase 2 (ck2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies. | cervical cancer is now considered the second leading cause of death among women worldwide, and its incidence has reached alarming levels, especially in developing countries. similarly, high grade squamous intraepithelial lesion (hsil), the precursor stage for cervical cancer, represents a growing health problem among younger women as the hsil management regimes that have been developed are not fully effective. from the etiological point of view, the presence of human papillomavirus (hpv) has bee ... | 2009 | 19439079 |
| evaluation of an array-based method for human papillomavirus detection and genotyping in comparison with conventional methods used in cervical cancer screening. | cervical cancer is the second-most prevalent cancer in young women around the world. infection with human papillomavirus (hpv), especially high-risk hpv types (hr-hpv), is necessary for the development of this cancer. hpv-dna detection is increasingly being used in cervical cancer screening programs, together with the papanicolau smear test. we evaluated the usefulness of introducing this new array-based hpv genotyping method (i.e., clinical arrays papillomavirus humano) in the cervical cancer s ... | 2009 | 19439534 |
| human papillomavirus and genital cancer. | human papillomavirus (hpv) is one of the most common sexually transmitted infections world-wide. low-risk hpv-types are associated with genital warts. persistent infection with high-risk hpv-types is associated with genital cancers. smoking and hiv infection have consistently been associated with longer duration of hpv infection and risk for genital cancer. there is an increasing incidence of anal cancers, and a close association with hpv infection has been demonstrated. receptive anal sex and h ... | 2009 | 19439875 |
| vaccines for human papillomavirus infection: a critical analysis. | this article takes a critical look at the pros and cons of human papillomavirus (hpv) vaccines. there is enough evidence to suggest that the prophylactic vaccines are efficacious in preventing various benign and malignant conditions (including cervical cancers) caused by hpv. even though the vaccine is costly, hypothetical analysis has shown that hpv vaccination will be cost effective in the long run. therapeutic hpv vaccines used to treat established disease are still undergoing evaluation in c ... | 2009 | 19439876 |
| human papillomavirus research: do we still need animal models? | 2009 | 19441096 | |
| distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy. | human papillomavirus (hpv) gene expression is dramatically altered during cervical carcinogenesis. because dysregulated genes frequently show abnormal patterns of dna methylation, we hypothesized that comprehensive mapping of the hpv methylomes in cervical samples at different stages of progression would reveal patterns of clinical significance. to test this hypothesis, thirteen hpv16-positive samples were obtained from women undergoing routine cervical cancer screening. complete methylation dat ... | 2009 | 19443004 |
| human papillomavirus type and clinical manifestation in seven cases of large-cell neuroendocrine cervical carcinoma. | large-cell neuroendocrine carcinoma (lcnec) of the uterine cervix is a very rare malignancy. we aimed to investigate the role of human papillomavirus (hpv) on the survival of patients, and its correlation with clinical parameters of hpv status or survival outcomes. only seven cases of lcnec were retrospectively collected among 8018 (0.087%) invasive cervical carcinomas from the cancer registry systems at mackay memorial hospital and veterans general hospital over a period of 17 years. the median ... | 2009 | 19443298 |
| human papillomavirus infection as a prognostic factor in oropharyngeal squamous cell carcinomas treated in a prospective phase ii clinical trial. | the aim of this study was to determine the presence of high-risk hpv-16 in patients with hnscc, assess the impact of hpv status on treatment response and survival in this select cohort treated with combined modality therapy and to identify the differences in hif-1alpha and vegf expression in hpv-positive and -negative tumors. | 2009 | 19443352 |
| opsoclonus myoclonus after human papilloma virus vaccine in a pediatric patient. | 2009 | 19447066 | |
| sulfated k5 escherichia coli polysaccharide derivatives: a novel class of candidate antiviral microbicides. | antiviral microbicides, topical agents that prevent sexually transmitted infections, mainly work by blocking the interaction between viral proteins and cell surface components. in many instances, virus-cell interaction is mediated by cell surface heparan sulfate proteoglycans (hspgs). hspgs are exploited as attachment receptors by three sexually transmitted viruses: human immunodeficiency virus (hiv), herpes simplex virus (hsv) and human papilloma virus (hpv). since these viruses can either infe ... | 2009 | 19447134 |
| how many cin2+ lesions can be avoided through hpv 16/18 vaccination? | 2009 | 19449218 | |
| [clinical, epidemiological, and pathogenetic aspects of formation of persisting forms of high oncogenic risk papillomavirus infection in women]. | to reveal factors related with presence of human papillomavirus in women. | 2009 | 19459488 |
| marrying research, clinical practice and cervical screening in australian aboriginal women in western new south wales, australia. | research shows that australian aboriginal women experience a significantly higher rate of mortality from cervical cancer than non-aboriginal women. we now understand that infection with human papillomavirus (hpv) is a necessary pre-requisite for cervical cancer. this knowledge, together with the development of prophylactic vaccines against the hpv types most commonly associated with cervical cancer (16 and 18), made it vital to gain nationally representative hpv genotyping data for australian wo ... | 2009 | 19459723 |
| surveillance of human papilloma virus infection and cervical cancer in kidney transplant recipients: preliminary data. | development of cancer after transplantation has rapidly became one of the leading causes of death in kidney transplant recipients with functioning grafts. anogenital malignant neoplasms may occur with a 14-fold increased incidence, and human papilloma virus (hpv) infection has been recently identified as the leading cause of cervical carcinoma. we report the preliminary findings of a prospective study that evaluated the incidence of hpv infection and cervical carcinoma in a population of kidney ... | 2009 | 19460514 |
| human papillomavirus-58 and -73-associated digital squamous cell carcinoma in a patient with aggressive digital papillary adenocarcinoma. | aggressive digital papillary adenocarcinoma (adpa) is a rare tumor that is considered to arise from eccrine sweat glands of the skin. it occurs predominantly in men with a mean age in the sixth decade. it shows a strong tendency for local recurrence and has the potential to metastasize to distant sites. prompt diagnosis and regular follow-up are important to ensure the best possible outcome. we discuss a case of recurrent adpa associated with subsequent squamous cell carcinoma (scc) in different ... | 2009 | 19461243 |
| [clear cells in cutaneous squamous cell carcinoma]. | although few cases of squamous cell carcinoma (scc) with clear cells have been published, we believe that these cells are often present in scc. | 2009 | 19463234 |
| vaccination with human papillomavirus type 16-derived peptides using a tattoo device. | tattooing has been shown to be very efficient at inducing immunity by vaccination with dna vaccines. in this study, we examined the usability of tattooing for delivery of peptide vaccines. we compared tattooing with subcutaneous (s.c.) needle injection using peptides derived from human papillomavirus type 16 (hpv16) proteins. we observed that higher peptide-specific immune responses were elicited after vaccination with the simple peptides (e7(44-62) and e7(49-57)) and keyhole limpet hemocyanin-( ... | 2009 | 19464530 |
| immune thrombocytopenic purpura following human papillomavirus vaccination. | 2009 | 19464550 | |
| knowledge of human papillomavirus: differences by self-reported treatment for genital warts and sociodemographic characteristics. | the aim of this study was to evaluate knowledge about human papillomavirus (hpv) in individuals with genital warts compared with women from the general population without genital warts. human papillomavirus (hpv) knowledge among women reporting treatment for genital warts compared with hpv knowledge in women reporting no treatment was assessed using data from the population-based 2005 health information national trends survey (hints). three percent (n = 97) of women answered "yes" and 97% (n = 3 ... | 2009 | 19466646 |
| recent advances in molecular gynaecological pathology. | this review gives an overview of recent advances in our understanding of the molecular basis of gynaecological malignancy, including cervical, vulval, endometrial and ovarian tumours. these advances are beginning to influence clinical practice, perhaps most notably with the introduction of human papillomavirus vaccination for the prevention of anogenital neoplasia, but are likely to have broader clinical implications as further details emerge. | 2009 | 19469886 |
| mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of rpe biology. | development of immortalized mouse retinal pigmented epithelial cell (rpe) lines that retain many of their in vivo phenotypic characteristics, would aid in studies of ocular diseases including age related macular degeneration (amd). rpe cells were isolated from 18-month-old (estrogen receptor knockout) erkoalpha and erkobeta mice and their c57bl/6 wildtype littermates. rpe65 and cellular retinaldehyde binding protein (cralbp) expression, in vivo markers of rpe cells, were detected by real-time rt ... | 2009 | 19013153 |
| fanconi anemia deficiency stimulates hpv-associated hyperplastic growth in organotypic epithelial raft culture. | fanconi anemia (fa) is a recessive genome instability syndrome characterized by heightened cellular sensitivity to dna damage, aplastic anemia and cancer susceptibility. leukemias and squamous cell carcinomas (sccs) are the most predominant fa-associated cancers, with the latter exhibiting markedly early disease onset and aggressiveness. although studies of hematopoietic cells derived from fa patients have provided much insight into bone marrow deficiencies and leukemogenesis, molecular transfor ... | 2009 | 19015634 |
| scythe/bat3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. | papillomavirus binding factor (pbf) was first identified as a transcription factor regulating the promoter activity of human papillomavirus. we previously demonstrated that pbf is an osteosarcoma-associated antigen and 92% of osteosarcoma tissues express pbf in the nucleus. moreover, pbf-positive osteosarcoma has a significantly poorer prognosis than that with negative expression of pbf. in the present study, we assessed the biological role of pbf in cell survival. overexpression of pbf induced ... | 2009 | 19018758 |
| oropharyngeal carcinoma in non-smokers and non-drinkers: a role for hpv. | incidence of oropharyngeal squamous cell carcinoma (oscc) increased 3% annually from 1973 to 2001. oscc's can be attributed to tobacco and alcohol, but 25% are unlinked to typical risks. case-control studies on hpv detection in non-smoking/non-drinking (ns/nd) oscc patients have not previously been performed. the primary objective of this study was to determine whether high-risk hpv infection was significantly associated with development of oral squamous malignancy in non-smokers/non-drinkers. a ... | 2009 | 19027350 |
| identification of the nuclear localization and export signals of high risk hpv16 e7 oncoprotein. | the e7 oncoprotein of high risk human papillomavirus type 16 (hpv16) binds and inactivates the retinoblastoma (rb) family of proteins. our previous studies suggested that hpv16 e7 enters the nucleus via a novel ran-dependent pathway independent of the nuclear import receptors (angeline, m., merle, e., and moroianu, j. (2003). the e7 oncoprotein of high-risk human papillomavirus type 16 enters the nucleus via a nonclassical ran-dependent pathway. virology 317(1), 13-23.). here, analysis of the lo ... | 2009 | 18996550 |
| different outcome of invasive cervical cancer associated with high-risk versus intermediate-risk hpv genotype. | human papillomavirus (hpv) dna sequences are associated with the large majority of invasive cervical carcinoma but the role of specific genotype(s) in the outcome of the disease is still debated. to determine the viral epidemiology in the french population of patients and the prognostic value of hpv genotypes in cervical cancer, we performed a retrospective study in 515 patients treated in our institution from 1985 to 2005. ninety-six percent of the cases were found associated with hpv dna where ... | 2009 | 19035459 |
| analysis of human papillomavirus type 18 load and integration status from low-grade cervical lesion to invasive cervical cancer. | the clinical value of viral load and integration testing for human papillomavirus (hpv) remains unclear. data on hpv type 18 (hpv18) is limited. we examined the hpv18 viral load and integration status of 78 women with normal cervix or neoplasia. while the crude viral load appeared to increase with lesion severity, the association was not significant after normalization with sample cellularity. unlike reports for hpv16, the amino-terminal 1 region of hpv18 e2 was most frequently (71.0%) disrupted ... | 2009 | 19036939 |
| augmentation of alphavirus vector-induced human papilloma virus-specific immune and anti-tumour responses by co-expression of interleukin-12. | to enhance the efficacy of a therapeutic immunisation strategy against human papillomavirus-induced cervical cancer we evaluated the adjuvant effect of interleukin-12 (il12) expressed by a semliki forest virus vector (sfv) in mice. depending on the dose and schedule, sfv-il12 stimulated antigen-specific ctl responses elicited upon immunisation with recombinant sfv expressing hpv16-e6e7 (sfvee6,7). sfvee6,7-ctl and anti-tumour activity were enhanced by a low dose of sfv-il12 to the prime immunisa ... | 2009 | 19041356 |
| analytical evaluation of the papillocheck test, a new commercial dna chip for detection and genotyping of human papillomavirus. | recently, a commercially available hpv dna chip, the papillocheck test, developed by greiner bio-one, has become available for human papillomavirus (hpv) genotyping. the papillocheck test is a pcr-based test using a new consensus primer set targeting the e1 hpv gene. hpv oligoprobes immobilized on a dna chip allow for the identification of 24 hpv types from the amplified product. in the present study, the analytical performance of the papillocheck test is compared to the linear array hpv genotyp ... | 2009 | 19041893 |
| prevalence of human papillomavirus types in cervical and oral cancers in central india. | cervical cancer that is associated with high-risk human papillomaviruses (hpv) is the most common malignancy in indian women. therefore, the establishment of a prevention program is urgently required considering both vaccination and screening. however, relatively little is known about the prevalence of the different hpv types in cervical cancers in different regions of india, particularly central india. in this study, we have determined the hpv type distribution in 180 cervical cancers of women ... | 2009 | 19056450 |
| whim syndrome: congenital immune deficiency disease. | warts, hypogammaglobulinemia, infections, and myelokathexis (whim) syndrome is characterized by susceptibility to human papilloma virus infection-induced warts and carcinomas; neutropenia, b-cell lymphopenia and hypogammaglobulinema-related infections; and bone marrow myelokathexis (myeloid hyperplasia with apoptosis). the purpose of this report is to review new findings about whim. | 2009 | 19057201 |
| distribution and density of cd1a+ and cd83+ dendritic cells in hpv-associated laryngeal papillomas. | respiratory papillomatosis associated with human papilloma virus (hpv) infection is the most common benign laryngeal neoplasm. the age of patients at disease onset, hpv type, number of surgeries are well known prognostic factors of the disease course. the correlation between dendritic cell (dc) density in tumor tissue and clinical prognosis was established. | 2009 | 19062106 |
| self-collection of genital human papillomavirus specimens in heterosexual men. | we assessed the accuracy of self-collected human papillomavirus (hpv) specimens in men compared with clinician-collected specimens from men in british columbia and determined the prevalence of hpv subtypes at different male genital sites. | 2009 | 19066196 |
| p16 ink4a immunostaining identifies occult cin lesions in hpv-positive women. | to evaluate whether p16 staining could help to recognize underestimated cervical intraepithelial neoplasia (cin) in women positive for high-risk human papillomavirus (hr-hpv) with negative biopsy. out of 1,259 women undergoing a histologic study and a simultaneous hr-hpv detection using the hybrid capture 2 test, we selected all patients testing positive for hr-hpv and having a negative biopsy (n=139), as well as all women testing negative for hr-hpv with a biopsy of either cin 1 (26 cases) or c ... | 2009 | 19047902 |
| anal intraepithelial neoplasia in a multisite study of hiv-infected and high-risk hiv-uninfected women. | to study anal intraepithelial neoplasia and its associations with anal and cervical human papillomavirus (hpv), cervical neoplasia, host immune status, and demographic and behavioral risk factors in women with and at risk for hiv infection. | 2009 | 19050387 |
| cervical cancer screening with liquid cytology in women with developmental disabilities. | to evaluate the use of liquid cytology in pap smears in women with developmental disabilities (dd) for endocervical cell yield and abnormalities, via speculum examination or blind technique. | 2009 | 19072727 |
| prevalence of human papillomavirus and chlamydia trachomatis infection among women attending cervical cancer screening in the republic of korea. | cervical cancer screening with the conventional papanicolaou test is recommended for the women aged 30 years and more in korea. cervical infection with human papillomavirus (hpv) is the most important cause of cervical cancer and chlamydia trachomatis (ct) is the most common bacterial sexually transmitted infection and may also be associated with risk of cervical cancer. a cross-sectional study of women attending the national cervical cancer screening program in busan and suwon was carried out. ... | 2009 | 19077566 |
| the common mechanisms of transformation by the small dna tumor viruses: the inactivation of tumor suppressor gene products: p53. | the small dna tumor viruses, polyoma virus, simian vacuolating virus 40, the papilloma viruses and the human adenoviruses, were first described during a period of intense virus discovery (1930-1960s) and shown to produce tumors in animals. in each of these cases the viral dna was shown to persist (commonly integrated into a host chromosome) and only a selected portion of this dna was expressed as m-rna and proteins in these cancers. the viral encoded tumor antigens were identified and shown to b ... | 2009 | 19081592 |
| the pro-angiogenic factors stimulated by human papillomavirus type 16 e6 and e7 protein in c33a and human fibroblasts. | to investigate the pro-angiogenic factors stimulated by human papillomavirus type 16 e6 and e7 protein in c33a and human fibroblasts. hpv-16 e6 and e7 genes were transfected into c33a and hfb to detect the profiling of angiogenesis-associated factors with the transignal angiogenesis antibody array. the mrna and protein levels of the cytokines were examined by traditional rt-pcr and western blotting in both cell lines before and after transfection of hpv-16 e6 and e7. hpv-16 e6 and e7 genes were ... | 2009 | 19082439 |
| the role of male circumcision in the prevention of human papillomavirus and hiv infection. | 2009 | 19086812 | |
| human papillomavirus 6 seropositivity is associated with risk of head and neck squamous cell carcinoma, independent of tobacco and alcohol use. | the risk of head and neck squamous cell carcinoma (hnscc) associated with common human papillomavirus types has not been well defined. | 2009 | 19087986 |
| diminished ifn-gamma and il-10 and elevated foxp3 mrna expression in the cervix are associated with cin 2 or 3. | cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (hpv) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (cin). additionally, regulatory t (treg) cells are increasingly understood to be important modulators of cellular immunity. using quantitative rt-pcr, we measured, in cross-sectional design, the cervical mrna expression of ifn-gamma, il-10, and il-12, as ... | 2009 | 19089920 |
| access of black, hispanic, and nonprivately insured women to liquid-based cytology, human papillomavirus dna testing, and on-site colposcopy in the united states. | to determine whether patient race, ethnicity, or insurance status was associated with access to cervical cancer screening with liquid-based cytology (lbc) and with human papillomavirus (hpv) dna testing and with access to on-site colposcopy at the provider's principal practice site. | 2009 | 19098602 |
| immunogenicity and safety of human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine in healthy boys aged 10-18 years. | the human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine (cervarix) has been shown to be well-tolerated and immunogenic in females aged 10 to 55 years, and up to 100% effective for the prevention of hpv-16/18 infection and associated precancerous cervical lesions in females aged 15 to 25 years. this study is the first to evaluate the immunogenicity and safety of the vaccine in males. | 2009 | 19101456 |
| determinants of incidence of primary fallopian tube carcinoma (pftc). | primary fallopian tube carcinoma (pftc) is a rare malignancy, but its incidence has been rising during the last decades and varies between 2.9/1,000,000 and 5.7/1,000,000. the epidemiology of pftc has been sparsely studied. in finland, the incidence rate has been rising during the last decades. the rise has been highest in the cities, in higher social classes, and in certain specific occupations. parity gives protection against this disease, as does a previous sterilization procedure. earlier th ... | 2009 | 19107444 |