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bilateral renal involvement by solitary fibrous tumor - report of a case in the post-who/2016 era. 201829276685
profiling of red pigment produced by streptomyces sp. jar6 and its bioactivity.actinomycetes strain was isolated from leaf litter soil sample and was identified as streptomyces sp. by conventional and molecular approaches. the biologically active compound responsible for antimicrobial and anticancer activity of the strain jar6 was elucidated by solid state fermentation followed by subsequent chromatographic and spectroscopic analysis. extraction, purification and structural confirmation of red pigment metabolite viz undecylprodigiosin were established on the basis of spect ...201829276660
wnt signaling perturbations underlie the genetic heterogeneity of robinow syndrome.locus heterogeneity characterizes a variety of skeletal dysplasias often due to interacting or overlapping signaling pathways. robinow syndrome is a skeletal disorder historically refractory to molecular diagnosis, potentially stemming from substantial genetic heterogeneity. all current known pathogenic variants reside in genes within the noncanonical wnt signaling pathway including ror2, wnt5a, and more recently, dvl1 and dvl3. however, ∼70% of autosomal-dominant robinow syndrome cases remain m ...201829276006
metabolic and vascular pattern in medial pterygoid muscle is altered by chronic stress in an animal model of hypodontia.psychological stress is an important perpetuating, worsening and risk factor for temporomandibular disorders of muscular or articular origin. occlusion instability, by the way, is considered a risk factor of this pathology and can be reproduced in some experimental animal models. the exact physiologic mechanism underlying these relations however, remains unclear. our purpose was to test the hypothesis that chronic stress and unilateral exodontia induce metabolic and vascular changes in the media ...201829275100
distinct features of c/n balance regulation in prochlorococcus sp. strain mit9313.the abundance and significant contribution to global primary production of the marine cyanobacterium prochlorococcus have made it one of the main models in marine ecology. several conditions known to cause strong effects on the regulation of n-related enzymes in other cyanobacteria lacked such effect in prochlorococcus. prochlorococcus sp. strain mit9313 is one of the most early-branching strains among the members of this genus. in order to further understand the c/n control system in this cyano ...201829267883
noise in early childhood education institutions.high sound pressure levels have been observed in schools, and its interference in the health of children and teachers it was taken to analyze these levels in childhood education centers serving children aged zero to six years, investigate the staff's perceptions concerning noise exposure and identify the auditory conditions of these workers and the occurrence of diseases. the study was conducted in ten institutions employing 320 workers. sound pressure levels were measured according to the techn ...201829267835
association between the risk of alcohol use and unprotected sex in adolescents in a city in the southern region of brazil.this paper aims to analyze alcohol abuse and unprotected sex and the association between them in students in a city in the southern region of brazil. this is a cross-sectional study using a quantitative approach with 590 secondary school students from two public schools. regarding alcohol use, 14% scored from eight to 40 in the alcohol use disorders identification test (audit), which means, at least, a risky drinking behavior, with higher rate among boys. moreover, 31.1% indulged themselves in b ...201829267834
factors associated with absences from orthodontic treatment at a dental specialty center.the aim of this study was to identify the factors associated with the users failing to keep orthodontic treatment appointments (absences), in three regional dental specialty centers (ceo-r) located in the state of ceará.201829267832
tuberculosis mortality trend in the state of paraná, brazil - 1998-2012.the objective was to analyze the trend in tuberculosis mortality in paraná from 1998 to 2012, according to healthcare macro-region-al, gender and age. ecological study of time series data with the system of the unified system mortality information health (sim/sus). trend analysis of standardized mortality rates was performed by linear regression segmented identifying the points with the change trend. there were 847 deaths of residents in paraná in the period. the trend was initially declining to ...201829267827
association between burnout syndrome, harmful use of alcohol and smoking in nursing in the icu of a university hospital.the article aims to determine the presence of burnout syndrome among professionals in the field of nursing in the intensive care unit in a university hospital and a possible association with consumption of alcohol and tobacco. participants were 160 nursing professionals from 04 intensive care unit of a university hospital in the period from march 2013 to february 2014. we used a structured questionnaire, plus the smoking history, maslach burnout inventory, alcohol use disorders identification te ...201829267824
prevalence of signs and symptoms of temporomandibular disorders in college preparatory students: associations with emotional factors, parafunctional habits, and impact on quality of life.the aim of this study was to evaluate the prevalence of temporomandibular disorders (tmd) signs and symptoms, its correlation with gender, parafunctional habits, emotional stress, anxiety, and depression and its impact on oral health-related quality of life (ohrql) in college preparatory students at public and private institutions in joão pessoa, paraíba (pb). the sample consisted of 303 students. presence of tmd symptoms was determined by an anamnesis questionnaire containing questions related ...201829267822
bayesian model and spatial analysis of oral and oropharynx cancer mortality in minas gerais, brazil.the objective of this study was to determine of oral and oropharynx cancer mortality rate and the results were analyzed by applying the spatial analysis of empirical bayesian model. to this end, we used the information contained in the international classification of diseases (icd-10), chapter ii, category c00 to c14 and brazilian mortality information system (sim) of minas gerais state. descriptive statistics were observed and the gross rate of mortality was calculated for each municipality. th ...201829267820
domestic violence against women, public policies and community health workers in brazilian primary health care.domestic violence creates multiple harms for women's health and is a 'wicked problem' for health professionals and public health systems. brazil recently approved public policies to manage and care for women victims of domestic violence. facing these policies, this study aimed to explore how domestic violence against women is usually managed in brazilian primary health care, by investigating a basic health unit and its family health strategy. we adopted qualitative ethnographic research methods ...201829267815
reporting child violence, health care flows and work process of primary health care professionals.this study aimed to analyze the flows of the network of children's protection against violence regarding reporting and decisions made. this is a qualitative research based on the theory of praxis interpretation of community health nursing - tipesc, proposed by egry, which seeks nursing intervention through a dynamic and participative methodology. data were collected through official documents and interviews with primary health care professionals in three health facilities of a brazilian city and ...201829267814
assessment of perceptions of clinical management in courses oriented by competency.the study aims to assess perceptions of mastery of abilities in clinical management in participants of courses oriented by competency and based on active methodologies of teaching and learning, before and after the offered training process. three conceptual frameworks were utilized: clinical management, expectation of auto-efficacy, and the holistic concept of competency. methodologically, an electronic instrument was made available to students of the training courses, adapted to the likert scal ...201829267808
perception, knowledge and attitudes of brazilian orthodontists on the treatment of class ii malocclusions.the present study aimed to assess the perception and knowledge of brazilian orthodontists on the ideal moment to treat class ii malocclusions. questionnaires with open, semi-open and close questions were sent by e-mail to 1653 brazilian orthodontists. these orthodontists were registered in the brazilian association of orthodontics and dentofacial orthopedics (abor). one-hundred and three (9.86%) orthodontists replied to the questionnaires. most of them were males (60.5%) with specialization as t ...201829267798
chemical composition and antibacterial activity of the essential oil of vitex agnus-castus l. (lamiaceae).abnormal multiplication of oral bacteria causes dental caries and dental plaque. these diseases continue to be major public health concerns worldwide, mainly in developing countries. in this study, the chemical composition and antimicrobial activity of the essential oil of vitex agnus-castus leaves (vac‒eo) collected in the north of brazil against a representative panel of cariogenic bacteria were investigated. the antimicrobial activity of vac-eo was evaluated in terms of its minimum inhibitory ...201829267797
cytogenetics and molecular genetic analysis of chimerism in marmosets (callithrix: primates).the birth of fraternal twins is a characteristic frequently observed in callitrichids. cytogenetic studies have demonstrated hematopoietic chimerism in marmosets with the occurrence of two cell lines 2n=46,xx/46,xy in females and males co-twins, without phenotypic changes. amplification by pcr have also been used to verify the presence of the sry gene in female chimaeras. our aim was to verify the occurrence of chimerism in callithrix sp. individuals considered as hybrids according to their inte ...201829267796
conservation of geosites as a tool to protect geoheritage: the inventory of ceará central domain, borborema province - ne/brazil.the ceará central domain, in the northern borborema province/ne brazil, encompasses important geological records (geosites) which allow understanding a relevant period of the earth's evolution, mainly associated to neoproterozoic brazilian/pan-african cycle and west gondwana amalgamation, besides neoarchean to ordovician records. the presented geoheritage inventory aims to characterise the geosites with scientific relevance of ceará central domain. by applying a method for large areas, the final ...201829267791
low-level laser therapy and anesthetic infiltration for orofacial pain in patients with fibromyalgia: a randomized clinical trial.to compare the analgesic effect of anesthetic infiltration of lidocaine 2% and low-level laser therapy (lllt) by gaalas into tender points of patients with orofacial pain and fibromyalgia (fm).201829274162
nutritional shortage augments cisplatin-effects on murine melanoma cells.melanoma incidence increases every year worldwide and is responsible for 80% of skin cancer deaths. due to its metastatic potential and resistance to almost any treatments such as chemo, radio, immune and targeted-therapy, the patients still have a poor prognosis, especially at metastatic stage. considering that, it is crucial to find new therapeutic approaches to overcome melanoma resistance. here we investigated the effect of cisplatin (cddp), one of the chemotherapeutic agents used for melano ...201829273566
metformin-induced anticancer activities: recent insights.metformin is a widely used antidiabetic drug, and there is evidence among diabetic patients that metformin is a chemopreventive agent against multiple cancers. there is also evidence in human studies that metformin is a cancer chemotherapeutic agent, and several clinical trials that use metformin alone or in combination with other drugs are ongoing. in vivo and in vitro cancer cell culture studies demonstrate that metformin induces both ampk-dependent and ampk-independent genes/pathways that res ...201829272251
palladium-catalyzed c-h bond acetoxylation via electrochemical oxidation.here we describe the development of a method for the pd-catalyzed electrochemical acetoxylation of c-h bonds. the oxidation step of the catalytic cycle is probed through cyclic voltammetry and bulk electrolysis studies of a preformed palladacycle of 8-methylquinoline. a catalytic system for c-h acetoxylation is then developed and optimized with respect to the cell configuration, rate of oxidation, and chemistry at the counter electrode. this transformation is then applied to substrates containin ...201829272130
mechanism and cis/trans selectivity of vinylogous nazarov-type [6π] photocyclizations †.vinylogous nazarov-type cyclizations yield seven-membered rings from butadienyl vinyl ketones via a photochemical [6π] photocyclization followed by subsequent isomerization steps. the mechanism of this recently developed method was investigated using unrestricted dft, sf-tddft, and casscf/nevpt2 calculations, suggesting three different pathways that lead either to pure trans, pure cis, or mixed cis/trans configured products. singlet biradicals or zwitterions occur as intermediates. the computati ...201829272118
fast projection/backprojection and incremental methods applied to synchrotron light tomographic reconstruction.iterative methods for tomographic image reconstruction have the computational cost of each iteration dominated by the computation of the (back)projection operator, which take roughly o(n3) floating point operations (flops) for n × n pixels images. furthermore, classical iterative algorithms may take too many iterations in order to achieve acceptable images, thereby making the use of these techniques unpractical for high-resolution images. techniques have been developed in the literature in order ...201829271774
identification of the dominant microbial species of spoiled crisp grass carp ( ctenopharyngodon idellus c. et v.) and grass carp ( ctenopharyngodon idellus) fillets during cold storage by culture-independent 16s rdna sequence analysis.a new freshwater cultivation species, crisp grass carp (cgc; ctenopharyngodon idellus c. et v.) has a special texture and is popular with consumers; thus, we should pay close attention to its storage conditions and bacterial degradation. cgc and grass carp (gc; ctenopharyngodon idellus) were commercialized as fillets and subsequently stored at 4 and 8°c. microbial growth parameters (total viable counts, psychrotrophic bacteria, and pseudomonas spp.), physicochemical data (ph and total volatile b ...201829271684
modulation of hexavalent chromium toxicity on οriganum vulgare in an acidic soil amended with peat, lime, and zeolite.dynamics of chromate (cr(vi)) in contaminated soils may be modulated by decreasing its phytoavailability via the addition of organic matter-rich amendments, which might accelerate cr(vi) reduction to inert chromite (cr(iii)) or high-cation exchange capacity amendments. we studied cr(vi) phytoavailability of oregano in a cr(vi)-spiked acidic soil non-treated (s) and treated with peat (sp), lime (sl), and zeolite (sz). the addition of cr(vi) increased the concentrations of cr(vi) and cr(iii) in so ...201829272798
histidine-lysine axial ligand switching in a hemoglobin: a role for heme propionates.the hemoglobin of synechococcus sp. pcc 7002, glbn, is a monomeric group i truncated protein (trhb1) that coordinates the heme iron with two histidine ligands at neutral ph. one of these is the distal histidine (his46), a residue that can be displaced by dioxygen and other small molecules. here, we show with mutagenesis, electronic absorption spectroscopy, and nuclear magnetic resonance (nmr) spectroscopy that at high ph and exclusively in the ferrous state, lys42 competes with his46 for the iro ...201829271191
the metagenome of caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing.studies underestimate the microbial diversity and genotypic traits in the snails' microbiome. caracolus marginella, a land snail native to caribbean islands, can adapt to different environments. our research focused on the generation of a metagenomic library from c. marginella gut, to further explore the diversity and functional traits. thirty specimens of c. marginella were collected from the four regions of puerto rico. high molecular weight (40 kb) metagenomic libraries were generated using a ...201829270447
novel actinomycin group compound from newly isolated streptomyces sp. rab12: isolation, characterization, and evaluation of antimicrobial potential.streptomyces sp. rab12 having potential to produce novel actinomycin group compounds was isolated from soil samples collected from csir-indian institute of chemical technology, hyderabad, india, garden premises using international streptomycetes project (isp) protocols. the 16s rrna sequence of the strain rab12 exhibited identity with streptomyces sp. 13647m and the sequence was deposited in ncbi under the accession number ky 203650 while the strain rab12 was deposited in the microbial type cult ...201829270734
knockout of the srebp system increases production of the polyketide fr901512 in filamentous fungal sp. no. 14919 and lovastatin in aspergillus terreus atcc20542.in the production of useful microbial secondary metabolites, the breeding of strains is generally performed by random mutagenesis. however, because random mutagenesis introduces many mutations into genomic dna, the causative mutations leading to increased productivity are mostly unknown. therefore, although gene targeting is more efficient for breeding than random mutagenesis, it is difficult to apply. in this study, a wild-type strain and randomly mutagenized strains of fungal sp. no. 14919, a ...201829270733
energy intake in short bowel syndrome: assessment by 24-h dietary recalls compared with the doubly labelled water method.short bowel syndrome (sbs) represents a serious intestinal absorption disorder, and patients may be prone to severe malnutrition. dietetic therapy is critically important both for immediate prognosis and successful long-term rehabilitation. to maintain energy balance, an accurate assessment of energy intake is required. our objective was to compare energy intake (ei) assessed by 24-h dietary recalls (eirecall), a standard clinical assessment, with the total energy expenditure measured by the dou ...201829268807
a review of data in medical request and the patient questionnaire for magnetic resonance evaluation of silicone breast implants.to analyze the quality and quantity of data in the questionnaires and in request forms for magnetic resonance imaging.201829267430
description and evaluation of experimental models for uterine transplantation in pigs.to evaluate the technique of uterine transplantation and the use of drugs used in the process of immunosuppression.201829267429
obesity, sarcopenia, sarcopenic obesity and reduced mobility in brazilian older people aged 80 years and over.to analyze which abnormalities in body composition (obesity, sarcopenia or sarcopenic obesity) are related to reduced mobility in older people aged 80 years and older.201829267428
translation and adaptation to brazilian portuguese of the lymphedema rating scale in head and neck cancer.translate to brazilian portuguese, culturally adapt and test the rating and classification scales of cervicofacial lymphedema of the md anderson cancer center head and neck lymphedema protocol (mdacc hnl) in patients undergoing treatment for head and neck cancer.201829267425
α-aminoxy-acid-auxiliary-enabled intermolecular radical γ-c(sp3 )-h functionalization of ketones.a method for site-specific intermolecular γ-c(sp3 )-h functionalization of ketones has been developed using an α-aminoxy acid auxiliary applying photoredox catalysis. regioselective activation of an inert c-h bond is achieved by 1,5-hydrogen atom abstraction by an oxidatively generated iminyl radical. tertiary and secondary c-radicals thus formed at the γ-position of the imine functionality undergo radical conjugate addition to various michael acceptors to provide, after reduction and imine hydr ...201829266582
radical-mediated intramolecular β-c(sp3)-h amidation of alkylimidates: facile synthesis of 1,2-amino alcohols.a new radical-mediated intramolecular β-c(sp3)-h amidation reaction of o-alkyl trichloro- or arylimidates is reported. various oxazolines were efficiently prepared from easily accessible alcohol starting materials. the trichloro-oxazoline products can be hydrolyzed under mild conditions to give valuable 1,2-amino alcohols. this amidation reaction exhibits a broad substrate scope and good functional group tolerance, and offers a powerful means for the c(sp3)-h functionalization of alcohols. mecha ...201829264599
fate of nanoparticles during alum and ferric coagulation monitored using single particle icp-ms.in this study, aluminum sulfate, ferric sulfate, ferric chloride, and poly(diallyldimethylammonium chloride) (pdadmac) coagulation removal of citrate-stabilized silver and gold nanoparticles (nps) and uncoated titanium dioxide, cerium dioxide, and zinc oxide nps was investigated using a single particle (sp) icp-ms direct monitoring technique. zone 2 (charge neutralization) coagulation was performed in river water and more commonly used zone 4 (sweep floc) coagulation was performed in both river ...201829277033
the first miccai challenge on pet tumor segmentation.automatic functional volume segmentation in pet images is a challenge that has been addressed using a large array of methods. a major limitation for the field has been the lack of a benchmark dataset that would allow direct comparison of the results in the various publications. in the present work, we describe a comparison of recent methods on a large dataset following recommendations by the american association of physicists in medicine (aapm) task group (tg) 211, which was carried out within a ...201829268169
biodegradation and detoxification of chlorimuron-ethyl by enterobacter ludwigii sp. ce-1.the application of the herbicide chlorimuron-ethyl has a lasting toxic effect on some succession crops. here, a bacterium capable of utilizing chlorimuron-ethyl as the sole source of nitrogen was isolated from the contaminated soil and was identified as enterobacter ludwigii sp. ce-1, and its detoxification and degradation of the herbicide were then examined. the biodegradation of chlorimuron-ethyl by the isolate ce-1 was significantly accelerated with increasing concentration (1-10mg/l) and tem ...201829268112
development of microsatellite markers using next-generation sequencing for the fish colossoma macropomum.tambaqui (colossoma macropomum) is a fish species from the amazon and orinoco rivers, with favorable characteristics to the cultivation system and great market acceptance in south america. however, the construction of a genetic map for the genetic improvement of this species is limited by the low number of molecular markers currently described. thus, this study aimed to validate gene-associated and anonymous (non-genic) microsatellites obtained by next generation sequencing (rna-seq and whole ge ...201829264733
low molecular weight polyethylenimine-grafted soybean protein gene carriers with low cytotoxicity and greatly improved transfection in vitro.a series of gene carriers (sp-pei) have been synthesized by acylation reaction between soybean protein and branched polyethylenimine with low molecular weight of 600, 1200 and 1800 da, and designed as sp-pei600, sp-pei1200 and sp-pei1800, respectively. sp-pei could effectively condense plasmid dna into nanoscale polyplexes with size range of 100-200 nm, and exhibited much lower cytotoxicity against 293t and sh-sy5y cells than that of branched polyethylenimine (25 kda). in vitro gene transfection ...201829262753
milling induced amorphisation and recrystallization of α-lactose monohydrate.preprocessing of pharmaceutical powders is a common procedure to condition the materials for a better manufacturing performance. however, such operations may induce undesired material properties modifications when conditioning particle size through milling, for example. modification of both surface and bulk material structure will change the material properties, thus affecting the processability of the powder. hence it is essential to control the material transformations that occur during millin ...201829262302
α-c-h alkylation of methyl sulfides with alkenes by a scandium catalyst.the c-h addition of sulfides to alkenes is an atom-efficient route for the functionalization and modification of sulfide compounds through c-c bond formation, but this transformation is highly challenging. we report here the regioselective α-c(sp3)-h addition of a wide range of methyl sulfides to a variety of olefins and dienes by a half-sandwich scandium catalyst. this protocol provides a unique route for the synthesis of diverse sulfide derivatives through c-c bond formation at a sulfur-adjace ...201829261308
fluorescent nanoparticles present in coca-cola and pepsi-cola: physiochemical properties, cytotoxicity, biodistribution and digestion studies.foodborne nanoparticles (nps) have drawn great attention due to human health concerns. this study reports the detection of the presence of fluorescent nps, about 5 nm, in two of the most popular beverages, coca-cola (coke) and pepsi-cola (pepsi). the nps contain h, c and o, three elements with a tunable emission and with a quantum yield of 3.3 and 4.3% for coke and pepsi, respectively. the presence of sp3-hybridized carbon atoms of alcohols and ethers bonds was confirmed by nmr analysis. the nps ...201829261040
three sequential c-n bond formations: tert-butyl nitrite as a n1 synthon in a three component reaction leading to imidazo[1,2-a]quinolines and imidazo[2,1-a]isoquinolines.tert-butyl nitrite serves the dual role of an oxidant as well as a n1 synthon in a multicomponent reaction involving quinolines, isoquinolines, and styrenes. herein, two sp2 c-h functionalizations of styrenes and one sp2 c-h functionalization of quinolines and isoquinolines lead to the formation of fused quinolines and isoquinolines via three sequential c-n bond formations.201829260562
correction to: whole chromosome painting reveals independent origin of sex chromosomes in closely related forms of a fish species.ere, we report that a paragraph from the "discussion" section of cioffi et al. (2011; p. 1070, 4th paragraph of column 1) was transcribed (with only minor edits) from an introductory paragraph previously published in chromosome research by o'meally et al.201829260363
reshaped fecal gut microbiota composition by the intake of high molecular weight persimmon tannin in normal and high-cholesterol diet-fed rats.it has been proposed that the gut microbiome may be related to obesity, and diet-induced obesity may induce changes in the gut microbiota composition. our previous studies suggested that persimmon tannin (pt), which is highly polymerized and non-absorbable in the intestine, showed anti-hyperlipidemic and cholesterol-lowering effects in animal models. considering that the possible composition modification effects of pt on intestinal bacteria might contribute to its anti-hyperlipidemic and cholest ...201829260181
culture of spirogyra sp. in a flat-panel airlift photobioreactor.spirogyra is a green filamentous freshwater algae on which recent studies reveal several promising properties and potential application possibilities in biotechnology. however, little is known about cultivation of spirogyra and even less about large-scale cultivations in closed growth systems. therefore, the aim of the present study was to elaborate the growth kinetics of spirogyra sp. in a commercially available and scalable photobioreactor. for this purpose, spirogyra sp. was grown indoors in ...201829259881
gastric neuroendocrine tumor: review and update.the frequency of gastric neuroendocrine tumors is increasing. reasons are the popularization of endoscopy and its technical refinements. despite this, they are still poorly understood and have complex management.201829257854
influence of structural defects on biomineralized zns nanoparticle dissolution: an in-situ electron microscopy study.the dissolution of metal sulfides, such as zns, is an important biogeochemical process affecting fate and transport of trace metals in the environment. however, current studies of in situ dissolution of metal sulfides and the effects of structural defects on dissolution are lacking. here we have examined the dissolution behavior of zns nanoparticles synthesized via several abiotic and biological pathways. specifically, we have examined biogenic zns nanoparticles produced by an anaerobic, metal-r ...201829258315
dietary compound proanthocyanidins from chinese bayberry (myrica rubra sieb. et zucc.) leaves attenuate chemotherapy-resistant ovarian cancer stem cell traits via targeting the wnt/β-catenin signaling pathway and inducing g1 cell cycle arrest.cancer stem cells (cscs) represent a small population of cancer cells characterized by self-renewal ability, tumorigenesis and drug resistance. ovarian cancer is one of the leading causes of death related to the female reproductive system in western countries and has been evaluated as a type of csc-related cancer in recent years. natural products have attracted great attention in cancer treatment in recent years due to drug resistance and a high relapse rate of ovarian cancer. chinese bayberry l ...201829256569
dynamic covalent chemistry enables formation of antimicrobial peptide quaternary assemblies in a completely abiotic manner.naturally occurring peptides and proteins often use dynamic disulfide bonds to impart defined tertiary/quaternary structures for the formation of binding pockets with uniform size and function. although peptide synthesis and modification are well established, controlling quaternary structure formation remains a significant challenge. here, we report the facile incorporation of aryl aldehyde and acyl hydrazide functionalities into peptide oligomers via solid-phase copper-catalysed azide-alkyne cy ...201829256509
mechanical characterization of diesel soot nanoparticles: in situ compression in a transmission electron microscope and simulations.incomplete fuel burning inside an internal combustion engine results in the creation of soot in the form of nanoparticles. some of these soot nanoparticles (snp) become adsorbed into the lubricating oil film present on the cylinder walls, which adversely affects the tribological performance of the lubricant. in order to better understand the mechanisms underlying the wear caused by snps, it is important to understand the behavior of snps and to characterize potential changes in their mechanical ...201829256432
assembly of diverse spirocyclic pyrrolidines via transient directing group enabled ortho-c(sp2)-h alkylation of benzaldehydes.a diversity-oriented synthesis of useful spirocyclic pyrrolidines was successfully accomplished via late-stage cascade reactions of o-succinimide-substituted benzaldehydes. a catalytic amount of aniline as a transient directing group was efficient for the ruthenium-catalyzed ortho-c(sp2)-h alkylation of benzaldehyde with maleimide. the in situ formed imine overrided a series of other traditional directing groups with excellent site selectivities. more importantly, only 0.5 mol % of ruthenium cat ...201829256251
bacterial cellulose membrane used as biological dressings on third-degree burns in rats.burn injuries represent a high risk of morbidity and mortality. the wound healing process is complex and requires the participation of different types of cells. therefore, new biomaterials, which innovate the wound healing process, are being investigated.201829254071
cellulose nanocrystals as carriers in medicine and their toxicities: a review.cellulose nanocrystals (cncs) are crystalline nanoparticles that present myriad applications. cncs are produced from a variety of renewable sources, and they can be chemically modified. although there are promising perspectives for introducing cncs into pharmaceutical formulations, prior to achieving commercial products the influence of many parameters such as extraction and toxicity of the resulting products must be revealed. since there is great physicochemical flexibility in the steps of obta ...201829254002
two-step economical welan gum production by sphingomonas sp. ht-1 from sugar industrial by-products.a two-step fermentation strategy using glucose mother liquor (gml) for cell growth and xylose mother liquor (xml) for welan gum synthesis was used to alleviate uneconomic welan gum fermentation. this study revealed: (1) optimal initial gml concentration was 11.7g/l (10g/l sugars contained); (2) optimal xml feeding strategy was pseudo-exponential fed-batch and feeding time was 12thh-54thh, amounting to 25.7g/l xml (20g/l sugars contained); and (3) in a 7.5-l bioreactor, welan gum concentration wa ...201829253990
chitosan derivatives targeting lipid bilayers: synthesis, biological activity and interaction with model membranes.the antimicrobial activity of chitosan and derivatives to human and plant pathogens represents a high-valued prospective market. presently, two low molecular weight derivatives, endowed with hydrophobic and cationic character at different ratios were synthesized and characterized. they exhibit antimicrobial activity and increased performance in relation to the intermediate and starting compounds. however, just the derivative with higher cationic character showed cytotoxicity towards human cervic ...201829253951
curaua and eucalyptus nanofibers films by continuous casting: mechanical and thermal properties.a wide variety of new green materials such as curaua leaf fibers (clfs) has potential applications in nanotechnology. this study aims to investigate the thermomechanical properties and morphological structure of cellulose nanocrystals (cncs) and cellulose nanofibrils (cnfs) films obtained by continuous casting. the cncs were obtained by acid hydrolysis and cnfs by mechanical shearing from bleached clfs and eucalyptus pulp. the morphology after continuous casting resulted in oriented nanofibers, ...201829253936
body mass index changes during pregnancy and perinatal outcomes - a cross-sectional study.to evaluate the relation between changes the body mass index (bmi) percentile, reflected in the atalah curve, and perinatal outcomes.201829253913
new insights into the evolutionary history of fungi from a 407 ma blastocladiomycota fossil showing a complex hyphal thallus.zoosporic fungi are key saprotrophs and parasites of plants, animals and other fungi, playing important roles in ecosystems. they comprise at least three phyla, of which two, chytridiomycota and blastocladiomycota, developed a range of thallus morphologies including branching hyphae. here we describe retesporangicus lyonii gen. et sp. nov., an exceptionally well preserved fossil, which is the earliest known to produce multiple sporangia on an expanded hyphal network. to better characterize the f ...201829254966
fungi and fungal interactions in the rhynie chert: a review of the evidence, with the description of perexiflasca tayloriana gen. et sp. nov.†.the lower devonian rhynie chert is one of the most important rock deposits yielding comprehensive information on early continental plant, animal and microbial life. fungi are especially abundant among the microbial remains, and include representatives of all major fungal lineages except basidiomycota. this paper surveys the evidence assembled to date of fungal hyphae, mycelial cords and reproductive units (e.g. spores, sporangia, sporocarps), and presents examples of fungal associations and inte ...201829254965
susceptibility of enterococcus faecalis and propionibacterium acnes to antimicrobial photodynamic therapy.bacterial resistance to available antibiotics nowadays is a global threat leading researchers around the world to study new treatment modalities for infections. antimicrobial photodynamic therapy (apdt) has been considered an effective and promising therapeutic alternative in this scenario. briefly, this therapy is based on the activation of a non-toxic photosensitizing agent, known as photosensitizer (ps), by light at a specific wavelength generating cytotoxic singlet oxygen and free radicals. ...201829253813
palladium-catalyzed site-selective sp3 c-h bond thiocyanation of 2-aminofurans.alkyl thiocyanates are prevalent in natural products, drugs, and biologically active compounds. we report here a novel, mild, and efficient pd-catalyzed site-selective sp3 c-h bond thiocyanation of 2-aminofurans. using na2s2o8 as the oxidant and readily available nascn as the thiocyanation reagent, the kinetically favorable 2-amino-4-thiocyanatomethylfurans are selectively synthesized in promising yields with a broad substrate scope. this reaction represents the first example of transition-metal ...201829251508
pulsed electromagnetic field improves subchondral bone microstructure in knee osteoarthritis rats through a wnt/β-catenin signaling-associated mechanism.pulsed electromagnetic field (pemf) is often used for management of osteoarthritis (oa). the aim of the study was to determine whether pemf can successfully improve subchondral bone microstructure through a wnt/β-catenin signaling-associated pathway in rats with knee oa induced by low-dose monosodium iodoacetate (mia). seventy-two 12-week-old male sprague-dawley rats were randomly assigned to three groups: oa (n = 24), pemf (n = 24), and control (n = 24). oa was induced (oa and pemf groups) by i ...201829251361
association of pain catastrophizing with static balance, mobility, or functional capacity in patients with knee osteoarthritis: a blind cross-sectional study.the aim of this study was to investigate whether catastrophizing is associated with static balance, mobility, and functional capacity in patients with knee osteoarthritis.201829249415
correlation between severity of temporomandibular disorder, pain intensity, and pressure pain threshold.the aim of the present study was to correlate the severity of temporomandibular disorder (tmd) with the pressure pain threshold over the temporomandibular joint and masticatory muscles.201829249414
avian metapneumovirus circulation in italian broiler farms.with increasing frequency, avian metapneumovirus (ampv) is reported to induce respiratory signs in chickens. an adequate knowledge of current ampv prevalence among italian broilers is lacking, with little information available on its economical and health impact on the poultry industry. in order to collect preliminary data on the epidemiological context of ampv in broiler flocks, a survey was performed in areas of northern italy with high poultry density from 2014 to 2016. upper respiratory trac ...201829253264
the 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3',4'-methylenedioxyphenyl]-coumarin downmodulates the fcγr- and cr-mediated oxidative metabolism and elastase release in human neutrophils: possible mechanisms underlying inhibition of the formation and release of neutrophil extracellular traps.in this study, we report the ability of a set of eight 3-phenylcoumarin derivatives bearing 6,7- or 5,7-dihydroxyl groups, free or acetylated, bound to the benzopyrone moiety, to modulate the effector functions of human neutrophils. in general, (i) 6,7-disubstituted compounds (5, 6, 19, 20) downmodulated the fcγ receptor-mediated neutrophil oxidative metabolism more strongly than 5,7-disubstituted compounds (21, 22, 23, 24), and (ii) hydroxylated compounds (5, 19, 21, 23) downmodulated this neut ...201829248721
post-cooling survival, growth and deformity rates in zebrafish embryos (danio rerio).this study investigated and analysed survival, growth and macro- and microscopic damage during the development of zebrafish embryos up to the adult stage after undergoing cooling. the embryos at 50% epiboly stage were selected, submerged in cryoprotectant solution of methanol and sucrose, cooled gradually to 0 ± 2°c temperature, and divided into two groups with different storage times (6 and 18 h). subsequently, the embryos were reheated, rehydrated and incubated normally. the experiment lasted ...201829248025
erratum for ito et al., "identification of the hcb gene operon involved in catalyzing aerobic hexachlorobenzene dechlorination in nocardioides sp. strain pd653". 201829247036
diversity of intestinal bacterial lactase gene in antibiotics-induced diarrhea mice treated with chinese herbs compound qi wei bai zhu san.the current investigation is trying to study the impact of the mixture of chinese herbs qi wei bai zhu san (qwbzs) on bacterial lactase gene from antibiotics-induced diarrhea (aad) mice, as the good curative effect of qwbzs on diarrhea. mice (6 mice per group) were randomly selected as control, model and treatment groups. to induce diarrhea, mice in both model and treatment groups were intragastrically injected with mixture of gentamycin sulfate and cefradine (23.33 ml kg-1 day-1) twice per day ...201829242764
the toxicity of graphene and its impacting on bioleaching of metal ions from sewages sludge by acidithiobacillus sp.the increasing production of graphene raised concerns about their releasing into sewage sludge, however, there is little information about graphene impacting on the growth of bacteria and hence their bioleaching of metal ions from sewages sludge. in this study, we reported that acidithiobacillus sp., isolated from sewages, were used to bioleach cu2+ and zn2+ from sewages sludge in the presence of graphene. the negative effect on the growth of acidithiobacillus sp. and dose-dependent were observe ...201829258009
a retrospective analysis of adverse effects of an in vivo fluoroquinolone antibiotic enrofloxacin treatment on oocyte quality in the common marmoset.here we report a retrospective analysis of negative effects of routine enrofloxacin treatment of recurrent diarrhea on the ovary and the developing oocytes of the common marmoset, a small new world primate. the most deleterious effect on oocytes was observed about two months post treatment suggesting that the enrofloxacin effect is on early growing follicles. manifestations of toxicity included decreased numbers of growing follicles and recovered culturable oocytes, as well as signs of early atr ...201829247838
cryptosporidium spp. in caged exotic psittacines from brazil: evaluation of diagnostic methods and molecular characterization.the aim of this study was to evaluate the prevalence of and diagnostic methods for cryptosporidium spp. in caged adult exotic parrots from southern and southeastern brazil. oocysts were purified from fecal samples from 463 psittacines by centrifugal-flotation in sheather's sugar solution. cryptosporidium spp. were detected by malachite green negative staining and nested pcr targeting the 18s rrna gene. cryptosporidium species were identified by sequencing nested pcr amplicons. samples were also ...201829247662
spironolactone voltammetric determination on renewable amalgam film electrode.in this study a new high sensitive method of spironolactone (sp) determination is proposed using voltammetric technique. as the working electrode amalgam film silver based electrode (hg(ag)fe) was applied, that resulted in obtaining low limit of spironolactone detection, ex. for the preconcentration time 45 s obtained detection limit was 4.7·10-9 mol l-1 (1.96·10-6 g l-1). the linear response of spironolactone signal on mercury film electrode was obtained in the range of concentration from 15·10 ...201829247657
the effects of trait impulsivity on proactive and reactive interference control.the current study used event-related brain potentials (erps) to explore whether self-reported trait impulsivity in healthy individuals might be differentially related to proactive and reactive interference control. participants with high and low impulsivity (hi and li, respectively) performed a modified version of the prime-target interference task. proactive interference control was induced in the mostly incongruent (mi) context and reactive interference control was induced in the mostly congru ...201829247631
human thyroid-stimulating hormone synthesis in human embryonic kidney cells and related n-glycoprofiling analysis for carbohydrate composition determination.a strain of embryonic human kidney cells (hek293) was transiently co-transfected with the expression vectors coding for the α- and β-subunits of human thyroid-stimulating hormone (htsh), and, for the first time, a human cell-derived recombinant htsh was synthesized and extensively characterized. the purification strategy involving two steps provided an overall yield of 55% and a purity level > 90%. the purified material (htsh-hek) was analyzed and compared to a cho-derived recombinant preparatio ...201829247366
loss of mtap expression is a negative prognostic marker in ewing sarcoma family of tumors.the ewing sarcoma family of tumors (esft) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. methylthioadenosine phosphorylase (mtap) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different types of neoplasms. however, the expression of this biomarker and its biological role in esft remain largely unknown.201829243509
cyp1a1 genetic polymorphism is a promising predictor to improve chemotherapy effects in patients with metastatic breast cancer treated with docetaxel plus thiotepa vs. docetaxel plus capecitabine.a prospective study was performed to compare the outcome for metastatic breast cancer (mbc) patients treated with docetaxel plus thiotepa (dt) or docetaxel plus capecitabine (dc), and to explore the value of cyp1a1*2c polymorphisms in predicting clinical efficacy of these chemotherapies.201829242966
kinetic characterization and structural modeling of an nadp+-dependent succinic semialdehyde dehydrogenase from anabaena sp. pcc7120.succinic semialdehyde dehydrogenases (ssadh) of cyanobacteria played a pivotal role in completing the cyanobacterial tricarboxylic acid cycle. the structural information of cofactor preference and catalysis for ssadh from cyanobacteria is currently available. however, the detailed kinetics of ssadh from cyanobacteria were not characterized yet. in this study, an all3556 gene encoding ssadh from anabaena sp. pcc7120 (apssadh) was amplified and the recombinant apssadh was purified homogenously. ki ...201829242124
activation of melanocytes in idiopathic guttate hypomelanosis after 5-fluorouracil infusion using a tattoo machine: preliminary analysis of a randomized, split-body, single blinded, placebo controlled clinical trial. 201829241792
base-controlled regioselective functionalization of chloro-substituted quinolines.we prepared a number of di- and trifunctionalized quinolines by selective metalation of chloro-substituted quinolines with metal amides followed by reaction with different electrophiles. metalation of the c-3 position of the quinolinic ring with lithium diisopropylamide at -70 °c is easy to achieve, whereas reaction with lithium-magnesium and lithium-zinc amides affords c-2 or c-8 functionalized derivatives in a regioselective fashion. these complementary methods could be rationalized by dft cal ...201829240427
reduction of graphene oxide thin films by cobaltocene and decamethylcobaltocene.reduced graphene oxide (rgo) films have been prepared by immersion of graphene oxide (go) films at room temperature in nonaqueous solutions containing simple, outer-sphere metallocene reductants. specifically, solutions of cobaltocene, cobaltocene and trifluoroacetic acid (tfa), and decamethylcobaltocene each showed activity for the rapid reduction of go films cast on a wide variety of substrates. each reactant increased the conductivity of the films by several orders of magnitude, with rgo film ...201829240401
comparative genomics of pathogenic leptospira interrogans serovar canicola isolated from swine and human in brazil.leptospira interrogans serovar canicola is one of the most important pathogenic serovars for the maintenance of urban leptospirosis. even though it is considered highly adapted to dogs, serovar canicola infection has already been described in other animals and even a few human cases. here, we present the genomic characterisation of two brazilian l. interrogans serovar canicola strains isolated from slaughtered sows (l0-3 and l0-4) and their comparison with human strain fiocruz lv133. it was obse ...201829236931
making the invisible visible: searching for human t-cell lymphotropic virus types 1 and 2 (htlv-1 and htlv-2) in brazilian patients with viral hepatitis b and c.with this study, the authors hope to alert clinicians regarding the presence of human t-cell lymphotropic virus type 1 and 2 (htlv-1/-2) infections in patients with viral hepatitis b and c in brazil. htlv-1/-2 were detected in 1.3% of hepatitis b virus (hbv)- and 5.3% of hepatitis c virus (hcv)-infected blood samples sent for laboratory viral load measurements. a partial association of human immunodeficiency virus (hiv)-1 and htlv-1/-2 infection was detected in patients with hcv (hiv+, 27.3%), w ...201829236927
ecological characterisation and infection of anophelines (diptera: culicidae) of the atlantic forest in the southeast of brazil over a 10 year period: has the behaviour of the autochthonous malaria vector changed?background in southeastern brazil, autochthonous cases of malaria can be found near atlantic forest fragments. because the transmission cycle has not been completely clarified, the behaviour of the possible vectors in those regions must be observed. a study concerning the entomological aspects and natural infection of anophelines (diptera: culicidae) captured in the municipalities of the mountainous region of espírito santo state was performed in 2004 and 2005. similarly, between 2014 and 2015, ...201829236924
organocatalytic c(sp3)-h functionalization via carbocation-initiated cascade [1,5]-hydride transfer/cyclization: synthesis of dihydrodibenzo[b,e]azepines.carbocation-initiated cascade [1,5]-hydride transfer/cyclization and dimerization reactions were developed to synthesize dihydrodibenzo[b,e]azepine and octahydrodipyrroloquinoline derivatives in high yields. these redox-neutral c(sp3)-h functionalization-involving cascade reactions feature transition-metal-free, high atom- and step-economy, and environmental friendliness with water as the sole byproduct.201829239184
comparison between conventional protective mechanical ventilation and high-frequency oscillatory ventilation associated with the prone position.to compare the effects of high-frequency oscillatory ventilation and conventional protective mechanical ventilation associated with the prone position on oxygenation, histology and pulmonary oxidative damage in an experimental model of acute lung injury.201829236845
mobility of polivinylpyrrolidone coated silver nanoparticles in tropical soils.experiments in saturated soil columns were performed to investigate the transport and retention of 25 nm and 75 nm silver nanoparticles stabilized with polyvinylpyrrolidone (pvp-agnps) in two brazilian soils (sandy and sandy-clay). the normalized concentration of the pvp-agnps was obtained through a flow injection analysis method based on the surface plasmon ressonance effect of the metallic nanoparticles. the use of the ultraviolet-visible spectroscopy (uv-vis) allows a rapid and low-cost analy ...201829241128
assessment of arsenic oxidation potential of microvirga indica s-mi1b sp. nov. in heavy metal polluted environment.arsenic oxidizing α-proteobacterial strain microvirga indica s-mi1b sp. nov. was isolated from metal industry soil and has the ability to oxidize 15 mm of arsenite [as(iii)] completely in 39 h. the strain s-mi1b resists to different heavy metals and it oxidizes arsenite in presence of li, pb, hg, sb(iii), cd, cr(vi), ni, and exhibited growth inhibitory effect in presence of hg, cu, and cd at higher concentration. the morphology of microvirga indica s-mi1b changed in presence of heavy metals howe ...201829241075
moxidectin residues in lamb tissues: development and validation of analytical method by uhplc-ms/ms.the development and validation of a throughput method for the quantitation of moxidectin residues in lamb target tissues (muscle, kidney, liver and fat) was conducted using ultra-high-performance liquid chromatography-tandem mass spectrometry (uhplc-ms/ms). to achieve higher recovery of the analyte from the matrices, a modified quechers method was used for sample preparation. the chromatographic separation was achieved using a zorbax eclipse plus c18 rrhd column with a mobile phase comprising 5m ...201829241059
direct activation of β-sp3-carbons of saturated carboxylic esters as electrophilic carbons via oxidative carbene catalysis.an n-heterocyclic carbene-catalyzed oxidative lumo activation of the β-cabons of saturated carboxylic esters is disclosed. this approach allows for efficient asymmetric access to lactams and lactones by directly installing functional groups to the typically inert β-sp3 carbons of saturated esters. the use of hobt as an additive was found to significantly improve both yields and enantioselectivities of the reactions.201829239615
phonon hydrodynamic heat conduction and knudsen minimum in graphite.in the hydrodynamic regime, phonons drift with a nonzero collective velocity under a temperature gradient, reminiscent of viscous gas and fluid flow. the study of hydrodynamic phonon transport has spanned over half a century but has been mostly limited to cryogenic temperatures (∼1 k) and more recently to low-dimensional materials. here, we identify graphite as a three-dimensional material that supports phonon hydrodynamics at significantly higher temperatures (∼100 k) based on first-principles ...201829236507
physiological response and productivity of safflower lines under water deficit and rehydration.water deficit is one of the major stresses affecting plant growth and productivity worldwide. plants induce various morphological, physiological, biochemical and molecular changes to adapt to the changing environment. safflower (carthamus tinctorius l.), a potential oil producer, is highly adaptable to various environmental conditions, such as lack of rainfall and temperatures. the objective of this work was to study the physiological and production characteristics of six safflower lines in resp ...201829236874
evaluation of anaerobic threshold in non-pregnant and pregnant rats.several studies present different methodologies and results about intensity exercise, and many of them are performed in male rats. however, the impact of different type, intensity, frequency and duration of exercise on female rats needs more investigation. from the analysis of blood lactate concentration during lactate minimum test (lacmin) in the swimming exercise, the anaerobic threshold (at) was identified, which parameter is defined as the transition point between aerobic and anaerobic metab ...201829236871
accuracy of linear measurements performed with two imaging software in cone-beam computed tomography scans of dry human mandibles.the present study aimed to assess the accuracy of linear measurements performed with two software packages in multislice (msct) and cone beam (cbct) computed tomography (ct) images. the sample consisted of 10 human mandibles marked standardly 8 times with metallic orthodontic wires. the mandibles underwent both msct and cbct scanning and were measured linearly and digitally with two software packages, namely studio 3.1® (anne solutions®, sp, brazil) (st) and implant viewer 2.817® (anne solutions ...201829236870
pollen morphology and viability in bromeliaceae.pollen morphology characterization is important in taxonomy, conservation and plant breeding, and pollen viability studies can support breeding programs. this study investigated pollen morphology and male fertility in 18 species of bromeliaceae with ornamental potential. for morphological characterization, pollen grains were acetolyzed and characterization of exine was done using scanning and transmission electron microscopy. pollen viability was investigated by in vitro germination and histoche ...201829236853
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