Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| a facile method for the assessment of dna damage induced by uv-activated nanomaterials. | fluorescent microscopy observation of gene-size dna (t4 phage dna or λ phage dna) was used to assess dna damage induced by uv irradiation in the presence of nanomaterials, such as qds (quantum dots: cdse/zns semiconductor nanoparticles), the water-soluble fullerene derivative c(60)(oh)(n) (n = 6-12) and titanium oxide nanoparticles of 25 nm in diameter. the magnitude of dna damage could be simply evaluated based on the degree of shortening of the stretched dna image. this method showed that dna ... | 2011 | 21614347 |
| idiopathic primary ovarian insufficiency: a study of serial hormonal profiles to assess ovarian follicular activity. | ovarian follicular activity in serial hormone profiles has been reported in up to 86% of patients with primary ovarian insufficiency (poi). in most of these studies, patients had a short duration of amenorrhea or irregular menstrual cycles which could influence the occurrence of spontaneous follicular activity. the aim was to study the incidence of follicular activity in serial hormonal profiles of women with spontaneous poi and amenorrhea of 1 year duration. | 2011 | 21669968 |
| the ability of phased-array mri in preoperative staging of primary rectal cancer: correlation with histopathological results. | purpose: this study evaluated the accuracy of phased-array mri for preoperative local tumor staging in primary rectal cancer and emphasized the importance of the preoperative differentiation of t2 tumors from t3 tumors so the appropriate treatment can be applied. materials and methods: twenty-four patients with primary rectal cancer were examined preoperatively using 1.5-t magnetic resonance imaging with a phased-array coil. multiplanar t2-weighted images were obtained. rectum anatomy, depth of ... | 2011 | 21671218 |
| adenocarcinoma of the ethmoid sinus: retrospective study of 42 cases. | objectives: retrospective analysis of the oncological results and morbidity of ethmoid sinus adenocarcinoma surgery, and identification of survival factors. material and methods: forty-two patients were treated from 1990 to 2009. the study covered clinical presentation, medical imaging, histologic data, tnm grade, treatment, morbidity and overall recurrence-free survival. results: forty-one men and one woman, with mean age at diagnosis of 61.5 years, were included. 85.7% had been exposed to wood ... | 2011 | 21616740 |
| [combined transplantation of a free skin island flap supplied by a septo-cutaneous perforator of the posterior tibial artery and the underlying fibula for the full reconstruction of the mandible and the mouth floor]. | microsurgical transplantation of the osteo-cutaneous fibula as a free flap to reconstruct the defect following radical resection of a mouth floor's tumor is a well-known and often applied procedure. anatomy of the vessels supplying this flap is recognized but it may have some rare and unexpected variations. in this case report we discuss the reconstruction of the middle and lateral parts of the mandible which was resected due to a t4 gingival tumor. interestingly, the aforementioned segment of t ... | 2011 | 21672684 |
| [the role of chemotherapy in the management of bladder cancer.] | bladder cancer represents for man the second genitourinary cancer after prostate cancer. urothelial carcinoma is the most predominant histological type. in up to 70% of the cases, the diagnosis of bladder cancer is performed at early stages (ta-t1). in this situation, the treatment of the disease is the transurethral resection with or without intravesical treatment (bcg, amiticyne). in advanced disease, treatment is essentially palliative with chemotherapy based on cisplatin type mvac (methotrex ... | 2011 | 21620296 |
| survival and quality of life following cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis of colonic origin. | background: peritoneal carcinomatosis of colonic origin (pcc) is a life-threatening diagnosis. cytoreductive surgery (cs) with hyperthermic intraperitoneal chemotherapy (hipec) offers patients the prospect of long-term survival with alleviation of symptoms. methods: patients underwent hipec for pcc and completed questionnaires preoperatively (t1) and after surgery at 3 (t2), 6 (t3), and 12 (t4) months. questionnaires included the functional assessment of cancer therapy-colon (fact-c), brief pain ... | 2011 | 21674272 |
| nick sealing by t4 dna ligase on a modified dna template: tethering a functional molecule on d-threoninol. | efficient dna nick sealing catalyzed by t4 dna ligase was carried out on a modified dna template in which an intercalator such as azobenzene had been introduced. the intercalator was attached to a d-threoninol linker inserted into the dna backbone. although the structure of the template at the point of ligation was completely different from that of native dna, two odns could be connected with yields higher than 90 % in most cases. a systematic study of sequence dependence demonstrated that the l ... | 2011 | 21815224 |
| neoadjuvant chemoradiation for clinically advanced non-small cell lung cancer: an analysis of 233 patients. | background: surgical intervention after chemoradiation for locoregionally advanced non-small cell lung cancer (nsclc) is controversial. this study evaluated patient survival after neoadjuvant chemoradiation and anatomic pulmonary resections for locoregionally advanced nsclc. methods: clinicopathologic data were retrospectively collected for 233 patients (110 women, 123 men) with nsclc who underwent chemoradiation therapy, followed by pneumonectomy, sleeve lobectomy, bilobectomy, and standard lob ... | 2011 | 21620372 |
| the role of laparoscopic and robotic cystectomy in the management of muscle-invasive bladder cancer with special emphasis on cancer control and complications. | context: minimally invasive radical cystectomy (mirc) techniques for the treatment of muscle-invasive bladder cancer (bca) are being increasingly applied. mirc offers the potential benefits of a minimally invasive approach in terms of reduced blood loss and analgesic requirements whilst striving to provide similar oncologic efficacy to open radical cystectomy (orc). whether quicker recovery, shorter hospital stay, and a reduction in complications are routinely achieved with mirc remains to be pr ... | 2011 | 21620562 |
| developmental treatment with bisphenol a or ethinyl estradiol causes few alterations on early preweaning measures. | since bisphenol a (bpa) exposure is nearly ubiquitous, increased knowledge of its potential effects on development will enable better risk assessment and regulatory guidance. here, sprague-dawley rats were reared in low exogenous estrogen environments. after breeding at adulthood, dams were gavaged on gestational days (gds) 6-21 with vehicle (veh), 2.5 or 25.0 μg/kg/day bpa, or 5.0 or 10.0 μg/kg/day ethinyl estradiol (ee(2)). offspring were orally treated on pnds 1-21 with the same dose the dam ... | 2011 | 21813462 |
| [intervention of astragalus injection on the kidney injury after cardiopulmonary bypass of infants with congenital heart disease]. | to study the intervention of astragalus injection in the kidney injury of infants with congenital heart disease after cardiopulmonary bypass, thus providing a new method for protection of the kidney injury in them. | 2011 | 21812263 |
| challenges in the management of stage ii colon cancer. | approximately one third of patients diagnosed with early-stage colon cancer will present with lymph node involvement (stage iii) and about one quarter with transmural bowel wall invasion but negative lymph nodes (stage ii). adjuvant chemotherapy targets micrometastatic disease to improve disease-free (dfs) and overall survival (os). while beneficial for stage iii patients, the role of adjuvant chemotherapy is unestablished in stage ii disease. this likely relates to the improved outcome of these ... | 2011 | 21810510 |
| [effects of lys-glu-asp-gly and ala-glu-asp-glypeptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds]. | the aim of the paper was to investigate effects of lys-glu-asp-gly and ala-glu-asp-gly peptides which were designed and synthesized on the basis of amino acid study of the hypophyseal anterior and posterior lobe peptides on the thyroid morphology and hormonal activity in mature chicken and old birds. hypophysectomy was established to produce atrophic changes in the thyroid gland and development of secondary hypothyrosis. administration of lys-glu-asp-gly and ala-glu-asp-gly tetrapeptides signifi ... | 2011 | 21809626 |
| transform and relax sampling for highly anisotropic systems: application to protein domain motion and folding. | transform and relax sampling (trs) is proposed as a conformational sampling method to enhance "soft" fluctuation in highly anisotropic systems using molecular dynamics simulation. this method consists of three stages; transform, relax, and sampling. in the transform stage, molecular dynamics simulation is performed with randomly assigned force bias to enhance the fluctuations along relatively soft collective movements, as expected from the linear response theory. after relaxing the heated system ... | 2011 | 21806159 |
| proposal of new nodal classifications for non-small-cell lung cancer based on the number and ratio of metastatic lymph nodes. | objective: the study aimed to evaluate the effectiveness of two new nodal classifications based on the number of metastatic lymph nodes (lns) or ratio of metastatic to examined lns (lnr) in making a prognosis, compared with the current nodal classification based on the location of metastatic lns. methods: we analyzed 651 non-small-cell lung cancer patients who had undergone complete resection with the removal of more than five lns between 1986 and 2003, excluding preoperative treatment cases, an ... | 2011 | 21620720 |
| intracellular detection of cytosine incorporation in genomic dna by using 5-ethynyl-2'-deoxycytidine. | 5-ethynyl-2'-deoxycytidine triphosphate (edctp) was synthesized as a probe to be used in conjunction with fluorescent labeling to facilitate the analysis of the in vivo dynamics of dna-centered processes (dna replication, repair and cytosine demethylation). kinetic analysis showed that edctp is accepted as a substrate by klenow exo(-) and dna polymerase ß. incorporation of 5-ethynyl-2'-deoxycytidine (edc) into dna by these enzymes is, at most, modestly less efficient than native dc. edc-containi ... | 2011 | 21805552 |
| comparison of two ventilation modes in post-cardiac surgical patients. | the cardiopulmonary bypass (cpb)-associated atelectasis accounted for most of the marked post-cpb increase in shunt and hypoxemia. we hypothesized that pressure-regulated volume-control (prvc) modes having a distinct theoretical advantage over pressure-controlled ventilation (pcv) by providing the target tidal volume at the minimum available pressure may prove advantageous while ventilating these atelactic lungs. | 2011 | 21804799 |
| changes in life style improve body composition, thyroid function and structure in obese children. | background. alterations in thyroid function and structure have been reported in obesity. function reverses to normal after weight loss, but nothing is known about structure. aim. to evaluate the effect of weight loss on thyroid function and structure in obese children. subjects and methods: the study was conducted in 72 overweight and obese children. measurement of ft3, ft4, tsh, antithyroid-antibodies and a thyroid ultrasound was performed at the beginning (phase 1) and after a period of 1.8 ± ... | 2011 | 21623157 |
| manserin as a novel histochemical neuroendocrine marker in prostate cancer. | objectives: to investigate the presence of manserin in human prostate cancers and to correlate manserin expression with pathologic outcomes and progression-free survival. methods: eighty-seven patients with recent prostate cancer were classified into 4 groups based on gleason score, and manserin immunohistochemistry was correlated with gleason sum grade. to investigate the validity of manserin as a prognostic factor, the cox proportional hazards regression model was performed on 48 patients in o ... | 2011 | 21803620 |
| cephalometric evaluation in different phases of jasper jumper therapy. | the aim of this study was to evaluate the dentoskeletal and soft-tissue effects of class ii malocclusion treatment with the jasper jumper followed by class ii elastics at the different stages of therapy. | 2011 | 21803237 |
| leptin-programmed rats respond to cold exposure changing hypothalamic leptin receptor and thyroid function differently from cold-exposed controls. | we showed that neonatal leptin treatment programmes for hyperleptinemia and central leptin resistance both at 30days-old and adulthood, while programmes for lower serum t3 at 30days-old, but higher thyroid hormones (th) at adulthood. as in these animals, acute cold at 30days-old normalized leptinemia and restored the expression of hypothalamic leptin receptor (obr), here we evaluate the effect of cold exposure on the thyroid function and obr in adult rats programmed by neonatal hyperleptinemia. ... | 2011 | 21803077 |
| eus and magnetic resonance imaging in the staging of rectal cancer: a prospective and comparative study. | accurate locoregional staging is crucial in rectal cancer for deciding patient management because the administration of neoadjuvant therapy depends on it. eus and magnetic resonance imaging (mri) are used indistinctly in the pretherapeutic workup of rectal cancer. | 2011 | 21802588 |
| boty-like retrotransposons in the filamentous fungus botrytis cinerea contain the additional antisense gene brtn. | long-terminal repeat (ltr) retrotransposons typically contain gag, pol, or gag-pol, and in some case env genes. in this work, we used data mining of the botrytis cinerea genomic sequence and a molecular approach to identify boty-like ltr retrotransposons in b. cinerea containing an antisense gene (brtn) between pol and the 3'-ltr. reverse transcriptase pcr (rt-pcr) revealed that some brtn-like genes could be expressed, at least in b. cinerea t4. we conducted blast comparisons and conserved-domai ... | 2011 | 21802103 |
| effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy. | background maternal hypothyroidism (oh and sch) during early pregnancy is suspected to associate with adverse obstetrical outcomes. aim the aim of the present study was to investigate whether maternal subclinical hypothyroidism during the early stage of pregnancy increase obstetrical complications and whether treatment results in an improvement in these outcomes. subjects and methods a total of 756 women in the first trimester (≤12 weeks) of pregnancy were enrolled through ten hospitals in sheny ... | 2011 | 21642766 |
| long-term response in advanced bladder cancer involving the use of temsirolimus and vinflunine after platin resistance. | relapse after initial first-line chemotherapy shows a poor prognosis in metastatic urothelial cancer. currently, several chemotherapeutic agents and targeted drugs are under evaluation for platin-resistant advanced urothelial carcinoma. vinflunine has been approved for second-line treatment in this indication. we present a patient with initial t4 advanced and subsequently metastasized bladder cancer, who has shown prolonged survival of 44 months after radical cystectomy. during her clinical cour ... | 2011 | 21642839 |
| could thyroid dysfunction influence outcome in sunitinib-treated metastatic renal cell carcinoma? | background: sunitinib is a standard of care for metastatic renal cell carcinoma (mrcc). hypothyroidism is frequently observed under sunitinib therapy. this study was conducted to prospectively determine the correlation between thyroid function and progression-free survival (pfs) in this population. patients and methods: one hundred and eleven mrcc patients treated with sunitinib were evaluated for serum thyroid-stimulating hormone (tsh) and t4 levels before treatment and every 6 weeks during tre ... | 2011 | 21653681 |
| metastatic prostate cancer in ossification of the ligamentum flavum-a case report. | background context: no previous reports have described a metastatic tumor located in the ossification of the ligamentum flavum (olf). purpose: to report an extremely rare case of metastatic tumor located in the olf. study design: case report. methods: we report a case of a 54-year-old man who sustained paraparesis attributable to spinal cord compression because of olf in the thoracic spine. results: the olf at t3/t4 and t5/t6, together with the laminae of t3-t6, was resected. histologically, the ... | 2011 | 21798814 |
| late onset pott's paraplegia in patients with upper thoracic sharp kyphosis. | purpose: the purpose of this study was to determine the clinical results of patients with late onset upper thoracic sharp pott's kyphosis and to predict the prognosis for pott's paraplegics. method: the study included five patients who developed late onset upper thoracic (t1-t4) sharp pott's kyphosis /kyphoscoliosis within a period from 19 to 37 years after the active disease was healed. the kyphosis angle of the patients ranged from 95° to 105°. among them, three patients suffered onset of para ... | 2011 | 21656306 |
| screw motion regulates multiple functions of t4 phage protein gp5 during cell puncturing. | bacteriophage t4 penetrates the outer membrane of escherichia coli using a multifunctional device composed of a gene product 5 (gp5) protein trimer. we report that gp5 sequentially exerts distinct functions along the course of penetration stages induced by screw motion. a triple-stranded ß-helix of gp5 act as a cell-puncturing drill bit to make a hole on the membrane and then send the lipids upwards efficiently by strong charge interactions. the gp5 lysozyme domains, which degrade the peptidogly ... | 2011 | 21793574 |
| relevance of both individual risk factors and occupational exposure in cancer survival studies: the example of intestinal type sinonasal adenocarcinoma. | objectives/hypothesis: wood dust is a well-established risk factor for intestinal type sinonasal adenocarcinoma. the 5-year overall survival has varied from 20% to 80% according t1-t4 stages; 5-year survival according to histologic subtype has varied from 20% to 50%. to date, no study has evaluated whether environmental, occupational, and personal risk factors have any impact on both overall and cancer-specific survival. we aimed to determine whether exposure to carcinogenic risk factors besides ... | 2011 | 21792978 |
| detection of 5-hydroxymethylcytosine in dna by transferring a keto-glucose by using t4 phage β-glucosyltransferase. | 2011 | 21656634 | |
| thyroxine and free thyroxine levels in workers occupationally exposed to inorganic lead. | the effects of lead exposure on thyroid function are unclear. | 2011 | 21792313 |
| adjuvant chemoradiotherapy for locoregionally advanced and high-risk salivary gland malignancies. | abstract: background: to report the outcomes of patients with locoregionally advanced and high- risk salivary gland malignancies treated with surgery followed by adjuvant chemoradiotherapy. methods: from 09/1991 - 06/2007, 24 high-risk salivary gland cancer patients were treated with surgery, followed by adjuvant chemoradiotherapy for high-risk pathologic features including, perineural involvement, nodal involvement, positive margins, or t3/t4 tumors. chemoradiotherapy was delivered for 4-6 alte ... | 2011 | 21791072 |
| multivisceral resection for primary locally advanced rectal carcinoma. | pelvic multivisceral resection offers the possibility of cure in patients with locally advanced rectal cancer. this study assessed the clinical outcome and determinants of survival and local recurrence in patients undergoing multivisceral resection for clinical t4 primary rectal cancer. | 2011 | 21656723 |
| catecholamine secreting paraganglioma of the thoracic spinal column: report of an unusual case and review of the literature. | background and importance:: paragangliomas are rare tumors of neuroendocrine origin that arise from paraganglionic tissue of the extrachromaffin cell system. these lesions may be seen at various sites along the neuroaxis. primary thoracic paragangliomas have rarely been in the literature, with secretory thoracic lesions being exceedingly rare as only three previous cases have been cited. clinical presentation:: a 49 year old female presented with episodes of hypertension, palpitations, and diaph ... | 2011 | 21788916 |
| preoperative serum carbohydrate antigen 242 is a useful predictive and prognostic marker in colorectal cancer. | tumor markers (tm) play an important role in the management of colorectal cancer (crc). this study evaluates the predictive and prognostic value of preoperative serum carbohydrate antigen 242 (ca242) in crc. | 2011 | 21661399 |
| feed intake and utilization in sheep fed graded levels of dried moringa (moringa stenopetala) leaf as a supplement to rhodes grass hay. | the effects of feeding graded levels of dried moringa (moringa stenopetala) leaf on intake, body weight gain (bwg), digestibility and nitrogen utilization were studied using male sheep (bw of 13.8?±?0.12 kg). six sheep were randomly allocated to each of the four treatment diets: rhodes grass (chloris gayana) hay offered ad libitum (t1), hay?+?150 g moringa leaf (t2), hay?+?300 g moringa leaf (t3), hay?+?450 g moringa leaf (t4) were offered daily. a 7-day digestibility trial and an 84-day growth ... | 2011 | 21786162 |
| multivisceral resection for gastric cancer: a systematic review. | background: the overall prognosis and survival of patients with advanced gastric cancer is generally poor. one of the most powerful predictors of outcomes in gastric cancer surgery is an r0 resection. however, the extent of the required surgical resection and the additional benefit of multivisceral resection (mvr) are controversial. methods: electronic literature searches were conducted using medline, embase, and the cochrane central register of controlled trials from january 1, 1998 to december ... | 2011 | 21785926 |
| mortality among men with locally advanced prostate cancer managed with noncurative intent: a nationwide study in pcbase sweden. | there are limited prognostic data for locally advanced prostate cancer pca to guide in the choice of treatment. | 2011 | 21664039 |
| in vitro ultramorphological assessment of apoptosis on cemss induced by linoleic acid-rich fraction from typhonium flagelliforme tuber. | the plant typhonium flagelliforme, commonly known as "rodent tuber" in malaysia, is often used as a health supplement and traditional remedy for alternative cancer therapies, including leukemia. this study aimed to evaluate in vitro anti-leukemic activity of dichloromethane extract/fraction number 7 (dcm/f7) from t. flagelliforme tuber on human t4 lymphoblastoid (cemss) cell line. the dcm extract of tuber has been fractionated by column chromatography. the obtained fractions were evaluated for i ... | 2011 | 21785623 |
| do inertial sensors represent a viable method to reliably measure cervical spine range of motion? | a rise in neck pain cases has initiated an exponential interest in the assessment and treatment of cervical spine range of motion (crom). experimental limitations, however, have been reported as therapists strive to collect continuous, dynamic data to aid prognosis. this technical report seeks to explore the viability of using inertial sensors to reliably assess crom. in recognition of the need for secure skin-sensor attachment, four combinations of sensor pairings were established and investiga ... | 2011 | 21784696 |
| pre-operative bevacizumab, capecitabine, oxaliplatin and radiation among patients with locally advanced or low rectal cancer: a phase ii trial. | background: to evaluate the safety and efficacy of pre-operative chemoradiation, using capecitabine, oxaliplatin and bevacizumab with standard doses of radiation, in patients with high-risk rectal cancer. methods: patients with locally advanced or low rectal cancer were treated with capecitabine 825mg/m(2) twice daily on days 1-14 and 22-35, oxaliplatin 50mg/m(2) on days 1, 8, 22 and 29, bevacizumab 5mg/kg on days 14, 1, 15 and 29, and radiation 50.4gy in 28 fractions including boost. total meso ... | 2011 | 21664123 |
| intensity-modulated radiotherapy (imrt)/tomotherapy following neoadjuvant chemotherapy in stage iib-iva/b undifferentiated nasopharyngeal carcinomas (ucnt): a mono-institutional experience. | to evaluate the outcome of undifferentiated nasopharyngeal carcinomas (ucnt) treated with intensity-modulated radiation therapy with simultaneous integrated boost (sib), following induction chemotherapy. between january 2006 and june 2009, 52 patients with stage ii b-iva/b ucnt were treated either with linac-imrt or tomotherapy. all patients were scheduled to receive three cycles of cisplatin based neoadjuvant chemotherapy. with a median follow-up of 38.5months (range 12.3-64.1), 3year overall s ... | 2011 | 21783403 |
| radical prostatectomy for high-risk prostate cancer defined by preoperative criteria: oncologic follow-up in national multicenter study in 813 patients and assessment of easy-to-use prognostic substratification. | objectives: to estimate the effect of predictive factors for oncologic outcomes after radical prostatectomy (rp) for high-risk prostate cancer (pca). methods: a total of 813 patients underwent rp for high-risk pca in a national retrospective multi-institutional study. high-risk pca was defined as follows: prostate-specific antigen (psa) level >20 ng/ml, gleason score 8-10, and/or clinical stage t2c-t4 disease. the preoperative criteria of high-risk pca were studied in a logistic regression model ... | 2011 | 21783233 |
| efficacy of fluoro-2-deoxy-d-glucose positron emission tomography to evaluate responses to concurrent chemoradiotherapy for head and neck squamous cell carcinoma. | this study evaluates the utility of fluorodeoxyglucose-positron emission tomography (fdg-pet) in patients with head and neck squamous cell carcinoma (hnscc) who received concurrent chemoradiotherapy (ccrt). | 2011 | 21665394 |
| [application of free anterolateral thigh flap in head and neck surgery]. | to evaluate the results of reconstruction by free anterolateral thigh flaps (alt) after operation of head and neck tumors. | 2011 | 21781558 |
| acute loading and aging effects on myostatin pathway biomarkers in human skeletal muscle after three sequential bouts of resistance exercise. | to determine the influence of age and resistance exercise on myostatin pathway-related genes, younger (n = 10; 28 -¦ 5 years) and older (n = 10; 68 -¦ 6 years) men underwent four testing conditions (t1-t4). a baseline (t1) muscle sample was obtained, whereas the second and third biopsies were obtained 48 hours following the first and second training sessions (t2, t3), and a final biopsy was taken 24 hours following t3. the training sessions consisted of 3 sets of 10 repetitions (80% of one repet ... | 2011 | 21665986 |
| cationic phenylene ethynylene polymers and oligomers exhibit efficient antiviral activity. | the antiviral activities of poly(phenylene ethynylene) (ppe)-based cationic conjugated polyelectrolytes (cpe) and oligo-phenylene ethynylenes (ope) were investigated using two model viruses, the t4 and ms2 bacteriophages. under uv/visible light irradiation, significant antiviral activity was observed for all of the cpes and opes; without irradiation, most of these compounds exhibited high inactivation activity against the ms2 phage and moderate inactivation ability against the t4 phage. transmis ... | 2011 | 21667949 |
| purification of phage display-modified bacteriophage t4 by affinity chromatography. | abstract: background: affinity chromatography is one of the most efficient protein purification strategies. this technique comprises a one-step procedure with a purification level in the order of several thousand-fold, adaptable for various proteins, differentiated in their size, shape, charge, and other properties. the aim of this work was to verify the possibility of applying affinity chromatography in bacteriophage purification, with the perspective of therapeutic purposes. t4 is a large, ico ... | 2011 | 21627821 |
| beta blockers and breast cancer mortality: a population-based study. | purpose preclinical studies have demonstrated that antagonism of β(2)-adrenergic signaling inhibits several pathways necessary for breast tumor progression and metastasis. a series of population-based observational studies were conducted to examine associations between beta blocker use and breast tumor characteristics at diagnosis or breast cancer-specific mortality. patients and methods linked national cancer registry and prescription dispensing data were used to identify women with a diagnosis ... | 2011 | 21632503 |
| levothyroxine absorption in morbidly obese patients before and after roux-en-y gastric bypass (rygb) surgery. | background: roux-en-y gastric bypass (rygb) modifies the anatomical structure of the upper intestine tract, reduces gastric acid secretion, and may impair lt4 absorption. the aim of this study was to evaluate the lt4 absorption in morbidly obese patients before and after rygb. methods: thirty morbidly obese patients were divided in two groups: the ns group included 15 patients before rygb surgery (bmi = 43.1 ± 4 kg/m(2)), and the s group included 15 patients after surgery (bmi = 37.3 ± 4 kg/m(2) ... | 2011 | 21633823 |
| cultural rationales guiding medication adherence among african american with hiv/aids. | abstract to date, only modest gains have been achieved in explaining adherence to medical regimens, limiting effective interventions. this is a particularly important issue for african americans who are disproportionately affected by the hiv epidemic. few studies have focused on intragroup variation among african americans in adherence to art. the aim of this study was to identify and describe the cultural rationales guiding african american patients' formulation and evaluation of adherence. rat ... | 2011 | 21777141 |
| sentinel node biopsy should be offered in thin melanoma with mitotic rate greater than one. | background the american joint committee on cancer recently added mitotic rate (mr) to their seventh edition staging system for melanomas, which went into effect on january 1, 2010. mr has replaced the clark level of invasion for t1 melanomas. dermatologists and dermatopathologists should be aware of these new guidelines. objective to clarify how mr may be used to determine the prognosis of thin melanomas and to identify patients with thin melanomas who would be candidates for a sentinel lymph no ... | 2011 | 21635622 |
| increased thyroidal t4 to t3 conversion in autonomously functioning thyroid adenoma: from euthyroidism to thyrotoxicosis. | aim: the aim was to investigate whether the intrathyroid conversion of t4 to t3 in autonomously functioning thyroid adenoma (afta) tissue could influence serum t3 levels and suppression of tsh, especially in patients with borderline thyroid function. patients and methods: in ten patients with afta, thyroidal conversion of t4 to t3 was investigated in nodular and paranodular, tsh-suppressed tissue. all patients had normal serum t4 and suppressed tsh. serum t3 was normal in six, and borderline or ... | 2011 | 21640977 |
| concurrent superselective intra-arterial chemotherapy and radiotherapy for late-stage squamous cell carcinoma of the temporal bone. | this study evaluated the efficacy of concurrent superselective intra-arterial chemotherapy and radiotherapy without surgery for late-stage squamous cell carcinoma of the temporal bone, which typically has a poor prognosis. | 2011 | 21774443 |
| prognostic and risk factors in patients with locally advanced cutaneous squamous cell carcinoma of the trunk and extremities. | 55 patients with advanced cutaneous squamous cell carcinoma (cscc) of the trunk and extremities were studied. a tissue microarray was constructed using immunohistochemistry to quantify expression of the her family, e-cadherins, and podoplanin. clinical and histopathological factors related to lymph node metastasis and prognosis were also established. primary tumor positivity was 25.5% for egfr, 87.3% for her-3, and 48.1% for her-4. metastases were positive for egfr in 41.7%, for her-3 in 83.3%, ... | 2011 | 21773035 |
| vertebral morphometry by x-ray absorptiometry: which reference data for vertebral heights? | the recent improvement in the resolution of dual-energy x-ray absorptiometry (dxa) images enables most vertebral levels to be seen adequately and thus dxa may be a worthwhile alternative to radiologic morphometry for the identification of vertebral fractures (vf). in this multicenter study, we have derived reference data for vertebral heights and their ratios in italian women using morphometric x-ray absorptiometry (mxa). | 2011 | 21672644 |
| vertebral body stapling as an alternative in the treatment of idiopathic scoliosis. | unilateral vertebral body stapling as a fusionless alternative to control curvature progression in patients with idiopathic scoliosis (is). | 2011 | 21674182 |
| lectin domains of polypeptide galnac-transferases exhibit glycopeptide binding specificity. | udp-galnac:polypeptide alpha-n-acetylgalactosaminyltransferases (galnac-ts) constitute a family of up to 20 transferases that initiate mucin-type o-glycosylation. the transferases are structurally composed of catalytic and lectin domains. two modes have been identified for the selection of glycosylation sites by galnac-ts: confined sequence recognition by the catalytic domain alone, and concerted recognition of acceptor sites and adjacent galnac-glycosylated sites by the catalytic and lectin dom ... | 2011 | 21768105 |
| should we treat mild subclinical/mild hyperthyroidism? no. | the management of a patient with subclinical hyperthyroidism or mild thyroid over-activity is controversial. subclinical hyperthyroidism is defined as a serum thyrotrophin (tsh) below the reference range but a normal thyroxine (t(4)) and triiodothyronine (t(3)) level in a patient who is either asymptomatic or has only non-specific symptoms. epidemiological studies report an overall prevalence of approximately 3%, with men and women over 65years and those in iodine deficient regions having the hi ... | 2011 | 21767747 |
| intuitive visualization and quantification of intraventricular convection in acute ischemic left ventricular failure during early diastole using color doppler-based echocardiographic vector flow mapping. | the aim of this study was to make an intuitive visualization of intraventricular convection (ic) and quantification of intraventricular convection velocity (icv) in acute ischemic left ventricular (lv) failure of open-chest canines during early diastole contrast to the baseline conditions using color doppler-based echocardiographic vector flow mapping (vfm). the animal care committee approved this prospective study. in 6 anesthetized open-chest beagle models, the emergence time and the emergence ... | 2011 | 21814809 |
| spinal intramedullary cysticercosis: a case report and literature review. | neurocysticercosis, involvement of the central nervous system by taenia solium, is one of the most common parasitic diseases of the cns. however, spinal involvement by neurocysticercosis is uncommon. here, we reported a 40-year-old woman with intramedullary cysticercosis in the thoracic spinal cord. mri revealed two well-defined round intramedullary lesions at t4 and t5 vertebral levels, which were homogeneously hypointense on t1wi and hyperintense on t2wi with peripheral edema. since the patien ... | 2011 | 21814474 |
| efficacy, safety and prognostic features of resected colon carcinoma treated in "real world" practice: a retrospective cohort-study. | treatment outcomes and prognostic features of a specific cancer generally come from prospective randomized studies. it seems reasonable to ask the question whether the results of prospective randomized studies entirely reflect the results of the population treated in "real world" practice. therefore we performed a retrospective cohort analysis in order to find out the efficacy of adjuvant chemotherapy as well as the prognostic factors of our patient population treated in daily practice, and comp ... | 2011 | 21766495 |
| the effect of lead acetate toxicity on experimental male albino rat. | the toxic effect of pb ion (lead acetate) was investigated using male albino rats, which was ingested at 1/20, 1/40, and 1/60 sublethal doses. relative to normal control, the ingestion of pb(2+) induced significant stimulation in alt and ast activity. in addition, total soluble protein and albumin contents of plasma were decreased, while the content of globulin was changed by the pb(2+) treatments. the cholinesterase activity was inhibited, but the activities of alkaline and acid phosphates as w ... | 2011 | 21766233 |
| effects of supraphysiological doses of levothyroxine on sleep in healthy subjects: a prospective polysomnography study. | disrupted sleep is prevalent in both mood and thyroid disorders. given the emerging use of thyroid hormones in the treatment of mood disorders, we investigated the effects of supraphysiological doses of levothyroxine (l-t4) on sleep. in an open-label design, 13 healthy subjects received up to 500?µg/day for an eight-week period. a baseline night was polysomnographically recorded (psg) followed by psg under the maximum tolerated dose of l-t4. all subjects developed hyperthyroxinemia. the heart ra ... | 2011 | 21765990 |
| trans-placental transfer of thirteen perfluorinated compounds and relations with fetal thyroid hormones. | while the results of animal studies have shown that perfluorinated compounds (pfcs) can modulate concentrations of thyroid hormones in blood, limited information is available on relationships between concentrations of pfcs in human blood serum and fetal thyroid hormones. the relationship between concentrations of pfcs in blood and fetal thyroid hormone concentrations or birth weight, and ratios of major pfcs between maternal and fetal serum were determined. concentrations of pfcs were measured i ... | 2011 | 21805959 |
| thyroid function in children with nephrotic syndrome. | this study was done to find out the thyroid function of nephrotic children during nephrosis and to compare any significant changes of thyroid function status during nephrosis and remission. this is an observational study with prospective follow up of study subjects. it was carried out over a period of one year from july'2006 to june'2007 in the department of paediatric nephrology, national institute of kidney diseases & urology (nikdu), dhaka, bangladesh. a total of 85 nephrotic children with in ... | 2011 | 21804503 |
| stereotactic radiosurgery in combination with chemotherapy as primary treatment for head and neck cancer. | purpose: the purpose of this study was to investigate the effect of stereotactic radiosurgery on local control and organ preservation in cases of primary head and neck cancer. patients and methods: in this retrospective study, 14 patients with a mean age of 73 years were treated between march 2006 and september 2007 with stereotactic radiosurgery for the management of primary head and neck cancer. the patients had biopsy confirmation of disease before treatment and all patients were confirmed wi ... | 2011 | 21764492 |
| the significance of abdominal para-aortic lymph node metastasis in patients with lower thoracic esophageal cancer. | para-aortic lymph node (paln) recurrence is often seen in patients with lower thoracic esophageal cancer treated by esophagectomy with extended lymph node dissection. however, the clinicopathological characteristics of patients with paln metastasis and the significance of paln dissection are unknown. a total of 283 patients with lower thoracic esophageal cancer underwent esophagectomy with lymphadenectomy at our hospital between april 1984 and march 2007. among these 283 patients, 60 patients we ... | 2011 | 21762280 |
| dissociated time course of recovery between genders after resistance exercise. | flores, df, gentil, p, brown, le, pinto, rs, carregaro, rl, and bottaro, m. dissociated time course of recovery between genders after resistance exercise. j strength cond res 25(x): 000-000, 2011-comparisons between men and women of time course responses of strength, delayed-onset muscle soreness (doms), and muscle swelling after a resistance training session are still controversial. therefore, this study examined gender differences in strength loss, muscle thickness (mt), and doms between young ... | 2011 | 21804429 |
| molecular detection and comparison of acanthamoeba genotypes in different functions of watersheds in taiwan. | the protistan genus acanthamoeba is a free-living amoeba existing in various environments. within this protistan genus, there are some species recognized as potential human pathogens, which may cause granulomatous amoebic encephalitis, acanthamoeba keratitis and chronic granulomatous lesions of the skin. in this study, 211 water samples were collected from two watersheds in southern taiwan. we detected acanthamoeba based on the pcr amplification with a genus-specific primer pair and investigatio ... | 2011 | 21800062 |
| staging and grading as prognostic factors in maxillary squamous cell carcinoma. | purpose: this retrospective study was performed to present our long-term results in the treatment of maxillary squamous cell carcinoma and evaluate especially the influence of t staging and grading on patients' survival. patients and methods: we performed a retrospective analysis of 93 consecutive patients with alveolar, gingival, or palatal maxillary scc treated at our clinic with surgical resection and/or radiation therapy. data were obtained from chart review and patients' records and were an ... | 2011 | 21752505 |
| mass spectrometric immunoassay for quantitative determination of transthyretin and its variants. | transthyretin (ttr, or prealbumin) is a tetrameric protein found in plasma and cerebrospinal fluid. its major role is to transport thyroid hormones (thyroxin-t4) and retinol (through association with retinol-binding protein). ttr has been studied extensively, due to the great number of point mutations that result in sequence heterogeneity. many of these variants are associated with pathological conditions that result in extracellular deposition of amyloid fibers in tissues. in this work, we have ... | 2011 | 21751365 |
| thyroid gland invasion in laryngopharyngeal squamous cell carcinoma: prevalence, endoscopic and ct predictors. | objectives: the authors studied the prevalence of histological thyroid gland invasion in laryngopharyngeal cancer and the preoperative endoscopic and ct signs predictive of this invasion. patients and methods: retrospective study of patients with laryngopharyngeal squamous cell carcinoma (t3 and t4) treated by total laryngectomy or total laryngopharyngectomy associated with concomitant total thyroidectomy or ipsilateral lobectomy and isthmectomy. results: eighty-seven patients were included. ele ... | 2011 | 21798840 |
| application of endoscopic sonography in preoperative staging of rectal cancer: six-year experience. | objectives- the aim of this study was to evaluate our experience with the application of endoscopic sonography in preoperative staging of rectal cancer. methods- between april 2004 and may 2010, 192 patients with rectal cancer first underwent endoscopic sonography and then underwent surgery at our hospital. none of the patients in this study received neoadjuvant therapy. the endoscopic sonographic staging results were compared with those of postoperative pathologic staging. results- the accuracy ... | 2011 | 21795480 |
| association between vitiligo and thyroid autoimmunity. | background. vitiligo is a common skin disorder characterized by macular depigmentation of the skin. the etiopathogenesis of the disease is still unclear, but there is evidence that autoimmunity and endocrine disfunction may be involved. objective. the aim of this study was to determine whether vitiligo is statistically associated with thyroid autoimmunity. method. in a prospective case-control study, we compared the frequency of thyroid autoantibodies (thyroglobulin antibody, anti-tg and thyroid ... | 2011 | 21747969 |
| speech impairment in primary hypothyroidism. | thyroid hormone deficiency may affect human speech and voice. the aim of this study was to evaluate speech variables in patients with hypothyroidism. | 2011 | 21747217 |
| t3+ and t4 rectal cancer patients seem to benefit from the addition of oxaliplatin to the neoadjuvant chemoradiation regimen. | background: to achieve t-downstaging and better resectability in locally advanced rectal cancer, neoadjuvant radiochemotherapy (rct) has become the current standard of treatment. a variety of schemes have been used. this study investigates which scheme had the best effect on these parameters. methods: our institution is a referral center for locally advanced rectal cancer. different neoadjuvant radiochemotherapy regimens were administered: long course radiotherapy (rth), 5-fu and leucovorin (5fu ... | 2011 | 21792506 |
| effects of dehydroepiandrosterone supplementation during stressful military training: a randomized, controlled, double-blind field study. | dehydroepiandrosterone (dhea) and dhea sulfate (dheas) are anabolic prehormones involved in the synthesis of testosterone. both have been shown to exert neuroprotective effects during stress. in this randomized, controlled, double-blind field study, we examined the effects of a 12-day dhea regimen on stress indices in military men undergoing survival training. forty-eight men were randomized to either a dhea treatment group or placebo control group. the treatment group received 50 mg of oral dhe ... | 2011 | 21790446 |
| protein profiling of angiogenesis-related growth factors in laryngeal carcinoma: pattern of protein expression in relation to tumour progression. | the expression of angiogenesis-related proteins was determined in laryngeal tumour tissue, associated tumour involved lymph nodes, apparently normal mucosa and control tissue and were related to tumour stage. both laryngeal tumour tissue and associated metastatic nodes were obtained from seven patients undergoing surgical resection; in four cases apparently normal mucosa was also dissected from the tumour specimen margins. control uvula mucosa was obtained from five healthy volunteers undergoing ... | 2011 | 21743965 |
| adjuvant chemotherapy for stage ii colon cancer with poor prognostic features. | purpose adjuvant chemotherapy is typically considered for patients with stage ii colon cancer characterized by poor prognostic features, including obstruction, perforation, emergent admission, t4 stage, resection of fewer than 12 lymph nodes, and poor histology. despite frequent use, the survival advantage conferred on patients with stage ii disease by chemotherapy is yet unproven. we sought to determine the overall survival benefit of chemotherapy among patients with stage ii colon cancer havin ... | 2011 | 21788561 |
| a retrospective study of salvage surgery for recurrent nasopharyngeal carcinoma. | background: nasopharyngeal carcinoma is sensitive to radiotherapy. when there is local relapse, re-irradiation treatment is inevitably associated with serious complications and decreased quality of life. surgical resection offers an alternative treatment option with acceptable morbidity. methods: seventy-one consecutive patients with primary recurrence of nasopharyngeal carcinoma after radiation underwent nasopharyngectomy from january 1, 1990 to june 30, 2006. follow-up ranged from 12 to 127-ám ... | 2011 | 21710155 |
| structural basis for sequence specific dna binding and protein dimerization of hoxa13. | the homeobox gene (hoxa13) codes for a transcription factor protein that binds to at-rich dna sequences and controls expression of genes during embryonic morphogenesis. here we present the nmr structure of hoxa13 homeodomain (a13dbd) bound to an 11-mer dna duplex. a13dbd forms a dimer that binds to dna with a dissociation constant of 7.5 nm. the a13dbd/dna complex has a molar mass of 35 kda consistent with two molecules of dna bound at both ends of the a13dbd dimer. a13dbd contains an n-terminal ... | 2011 | 21829694 |
| cd11d integrin blockade reduces the systemic inflammatory response syndrome after spinal cord injury. | traumatic injury to the spinal cord triggers a systemic inflammatory response syndrome (sirs), in which inflammatory cells from the circulation invade organs such as the liver, lung and kidney, leading to damage of these organs. our previous study (gris, et al, exp. neurol, 2008) demonstrated that spinal cord injury (sci) activates circulating neutrophils that then invade the lung and kidney from 2 to 24h after injury, increasing myeloperoxidase activity, cyclooxygenase-2 and matrix metalloprote ... | 2011 | 21784069 |
| a phase ii study of neoadjuvant chemoradiotherapy with oxaliplatin and capecitabine for rectal cancer. | purpose: this study evaluated the efficacy and safety of neoadjuvant chemoradiotherapy with the xelox regimen in rectal cancer patients. patients and methods: twenty-five patients with histopathologically confirmed and locally advanced rectal cancer (t3/t4 or n+) were enrolled in the study. radiotherapy of 5000cgy was delivered in 25 fractions of 200cgy five times per week for a total of 5weeks. during the first, second, fourth and fifth weeks of radiotherapy, the patients also received the foll ... | 2011 | 21782322 |
| re: aggressive surgical approach for patients with t4 gastric carcinoma: promise or myth? | 2011 | 21725684 | |
| highly sensitive chemiluminescent point mutation detection by circular strand-displacement amplification reaction. | single nucleotide polymorphism (snp) genotyping is attracting extensive attentions owing to its direct connections with human diseases including cancers. here, we have developed a highly sensitive chemiluminescence biosensor based on circular strand-displacement amplification and the separation by magnetic beads reducing the background signal for point mutation detection at room temperature. this method took advantage of both the t4 dna ligase recognizing single-base mismatch with high selectivi ... | 2011 | 21684734 |
| the association between thyroid hormones and arterial stiffness in peritoneal dialysis patients. | background/aims: the association between thyroid hormones and arterial stiffness is unclear. in this study, we investigated, for the first time in a large cohort of euthyroid peritoneal dialysis patients, the relationship between thyroid hormone levels and arterial stiffness. methods: fifty-seven patients were enrolled. serum tsh, free t3 and free t4 levels were measured by chemiluminescence immunoassay method. pulse wave analysis [augmentation index (aix) and subendocardial viability ratio (sev ... | 2011 | 21779917 |
| t4 rna ligase 2 truncated active site mutants: improved tools for rna analysis. | abstract: | 2011 | 21722378 |
| effects of uranium uptake on transcriptional responses, histological structures and survival rate of the crayfish procambarus clarkii. | this work aims to investigate the accumulation levels and effects (transcriptional responses, histopathology and survival rate) associated with a wide range of dissolved uranium (u) concentrations (0, 0.03, 0.6, 4 and 8mg/l of u) on adult male crayfish procambarus clarkii during 4 (t4) and 10 (t10) days of exposure. the follow-up of the crayfish mortality showed that p. clarkii was highly resistant to u. increasing waterborne u concentrations led to increasing bioaccumulation in key crayfish org ... | 2011 | 21741087 |
| erlotinib and chemoradiation in patients with surgically resected locally advanced squamous cell carcinoma of the head and neck: a gicor phase i trial. | background: standard treatment of advanced squamous cell carcinoma of the head and neck (scchn) is concurrent chemoradiation. erlotinib is an oral tyrosine kinase inhibitor of epidermal growth factor receptor, which has shown activity in scchn. phase i study aims to determine the maximum tolerated dose and dose-limiting toxicity (dlt) of adding erlotinib to chemoradiation therapy in patients with surgically resected locally advanced scchn. patients and methods: inclusion criteria-scchn patients ... | 2011 | 21778302 |
| effects of supplementing erythrina brucei leaf as a substitute for cotton seed meal on growth performance and carcass characteristics of sidama goats fed basal diet of natural grass hay. | the replacement value of dried erythrina brucei leaf for cotton seed meal (csm) on growth performance and carcass characteristics was evaluated. twenty-five yearling buck goats (15.8ôçë-¦ôçë1.4-ákg) were assigned into five treatments in a randomized complete block design: natural grass hay alone (t1) or supplemented with 100% csm (t2), 67% csmôçë+ôçë33% e. brucei (t3), 33% csmôçë+ôçë67% e. brucei (t4), and 100% e. brucei (t5) on dry matter (dm) basis. supplemented goats consumed more (pôçë<ôçë0. ... | 2011 | 21735342 |
| simple and efficient synthesis of 5' pre-adenylated dna using thermostable rna ligase. | we report a simple method of enzymatic synthesis of pre-adenylated dna linkers/adapters for next-generation sequencing using thermostable rna ligase from methanobacterium thermoautotrophicum (mthrnl). using rna ligase for the reaction instead of the existing chemical or t4 dna ligase-based methods allows quantitative conversion of 5'-phosphorylated single-stranded dna (ssdna) to the adenylated form. the mthrnl adenylation reaction is specific for atp and either ssdna or rna. in the presence of m ... | 2011 | 21724605 |
| correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas. | objective: the objective of this study was to analyze the relationship between the uptake of (18)f-2-fluoro-2-deoxy-d-glucose (fdg) by positron emission tomography-computerized tomography (pet-ct) and glucose metabolism/hypoxia markers in oral squamous cell carcinoma (oscc). study design: thirty-six patients with oscc (tongue [n = 23], buccal mucosa [n = 7], and floor of the mouth [n = 6]) were assessed and underwent incisional biopsy and subsequently received fdg-pet-ct. expressions of hypoxia- ... | 2011 | 21778086 |
| impact of cytoreductive nephrectomy on eligibility for systemic treatment and effects on survival: are surgical complications or disease related factors responsible? | objectives: to understand the impact of cytoreductive nephrectomy on the ability to receive systemic therapy in patients with metastatic renal cell carcinoma. causes of delayed eligibility and effect on overall survival (os) were investigated. methods: patients with metastatic renal cell carcinoma who underwent cytoreductive nephrectomy between 2002 and 2010 were identified. those ineligible to receive systemic therapy >2 months after surgery were considered delayed. reasons for delay and effect ... | 2011 | 21777963 |
| doubling the dose of clopidogrel restores the loss of antiplatelet effect induced by esomeprazole. | introduction: concerns have been raised about the potential adverse interaction between clopidogrel and ppis. we studied the impact of esomeprazole and ranitidine on the antiplatelet action of clopidogrel and aspirin and sought to determine whether doubling the dose of clopidogrel could restore its efficacy. materials and methods: in a randomized prospective crossover study, we tested platelet reactivity to aspirin and clopidogrel (75 and 150mg) with and without esomeprazole or ranitidine using ... | 2011 | 21777954 |
| elements of oxidation/reduction balance in experimental hypothyroidism. | the aim of this study was to investigate the effect of the decreased level of thyroid hormones on selected parameters of the oxidation/reduction balance by assessing the activity of antioxidant enzymes: superoxide dismutase (sod), and glutathione peroxidase (gsh-px); the level of antioxidant vitamins (a, c, and e); and the concentration of compounds reacting with thiobarbituric acid (tbars). | 2011 | 21717403 |
| comparison of methimazole and propylthiouracil in the management of children and adolescents with graves' disease: efficacy and adverse reactions during initial treatment and long-term outcome. | the aim of this study was to compare the efficacy and adverse reactions during initial treatment and long-term outcome between children and adolescents with graves' disease (gd) treated with propylthiouracil (ptu) and those treated with methimazole (mmi). | 2011 | 21823520 |
| twenty-year experience in the management of squamous cell anal canal carcinoma with interstitial brachytherapy. | objectives the aim of this study was to retrospectively evaluate clinical characteristics, local control, acute and late toxicity, and prognostic factors of patients with anal canal carcinoma treated with brachytherapy. methods from 1989 to 2009, 38 patients were treated with iridium 192 low-dose-rate (n=26) or pulsed-dose-rate (n=12) interstitial brachytherapy at a single institution. the median age was 62 years (range, 38-86 years). the tnm classification was as follows: 10 t1, 22 t2, 5 t3 and ... | 2011 | 21775274 |