Publications

a vaccine prepared from the 22 nm particles of surface hepatitis b antigen (hbsag).	a method for obtaining a subunit inactivated vaccine preparation from the 22-nm particles of hbsag is proposed. for inactivation of the residual infectious hepatitis b virus (hbv) the preparations were successively treated with 1% sodium dodecyl sulfate (sds) and nucleases. in addition, thermal denaturation and ultraviolet irradiation of hbv dna were used. as a control the biologic activity of a reference virus (sv40) was tested after the same treatment. the effectiveness of dna inactivation was ...	1980	7229622
antigenic relationship of a hepatitis b surface antigen-derived polypeptide and human serum albumin.	four major polypeptides with mol. wt. of 22000, 25000, 52000 and 68000 were isolated from solubilized preparations of hepatitis type b surface antigen (hbsag). these four populations, referred to as p22, p25, p52 and p68, respectively, were used to immunize guinea-pigs. guinea-pigs were also inoculated with hbsag and with purified human serum albumin (husa). these antisera were utilized to establish that intact hbsag particles are associated with husa antigenic reactivity. husa antigenic determi ...	1980	6156994
[experiments for the development of a hepatitis b vaccine: immunogenicity of hbsag in guinea pigs (author's transl)].	hepatitis b surface antigen (hbsag) was purified from human plasma by gel chromatography, isopyknic centrifugation, and zonal centrifugation. the final product had about 60% of the original activity and was essentially free from hepatitis b virus particles (hbv) and plasma proteins. treatment with formaldehyde concentrations up to 0.1% for inactivation of residual infectivity did not significantly reduce antigenicity in vitro and immunogenicity in guinea pigs. adsorption to aluminum hydroxide re ...	1979	572908
transmission experiments with hepatitis b surface antigen and the common bedbug (cimex lectularius l).	hepatitis b surface antigen (hbsag)-positive blood meals were fed to a colony of the common bedbug (cimex lectularius l) in a series of 5 experiments. antigen persisted in the bugs for at least 7 1/2 weeks, but was undetectable after 18 weeks. trans-stadial transmission was demonstrated through one moult only, and transovarial transmission did not occur. antigen was successfully transmitted by adult bugs into 3 out of 35 canisters of hbsag-negative blood. antibody of hbsag was detected in the se ...	1979	573506
immunochemical and oligonucleotide fingerprint analyses of venezuelan equine encephalomyelitis complex viruses.	rna oligonucleotide fingerprint analyses indicate that the genome rna obtained from trinidad donkey (trd) venezuelan equine encephalomyelitis (vee) virus serotype i a, its vaccine strain derivative tc-83, and the vee i b virus isolate ptf-39, have almost identical patterns of characteristic ribonuclease t1 resistant oligonucleotides. the tc-83 strain and the i b isolate can, on the basis of these analyses, be considered as variants of the trd virus and categorized as i ab serotypes. comparisons ...	1979	90115
the hepatitis b virus and its dna polymerase: the prototype three-d virus.	the hepatitis b virus (hbv), the causal agent of serum hepatitis, has a diameter of 42 nm and is comprised of an outer surface coat and a 27 nm core. a unique dna-dependent dna polymerase is associated with the core of the virus. the core also houses a circular dna that contains both double-stranded and single-stranded regions. in the endogenous reaction, the dna polymerase repairs the single-stranded gaps of the viral dna. the surface protein of the virus, called hepatitis b surface antigen, co ...	1979	91092
serological relationship of woodchuck hepatitis virus to human hepatitis b virus.	two antigenic systems of the woodchuck hepatitis virus have been identified. the relationship between viral antigens of the woodchuck hepatitis virus and the human hepatitis b virus was determined by using immunoprecipitation, hemagglutination, and immune electron microscopy techniques. antigens found on the cores of the two viruses were cross-reactive. lack of cross-reactivity between the surface antigens of the two viruses in immunodiffusion experiments suggested that the major antigenic deter ...	1979	94359
classification of porcine enteroviruses by antigenic analysis and cytopathic effects in tissue culture: description of 3 new serotypes.	porcine enteroviruses isolated in the united kingdom between 1972 and 1976 were compared with the 8 serotypes previously described and with human coxsackie b virus types 1 to 6 for ability to grow in different cell lines. this allowed the classification of all strains into 3 broad groups according to type of cytopathic effect in ibrs-2 cells and further subdivision on the basis of production of cytopathic effect in bhk 21, hela and vero cells. none of the porcine enterovirus strains was neutrali ...	1979	229804
properties of the erythrocyte receptors for influenza c virus.	properties of the receptor for influenza c virus were studied. although the receptor for influenza c virus on chicken erythrocytes was destroyed by the homologous virion, neuraminidase activity could not be detected in any of the influenza c virus strains tested. the receptor activity of chicken erythrocytes for influenza c virus was diminished by formaldehyde treatment but not by periodate oxidation. there was a considerable variation in the pattern and the titer of hemagglutination of influenz ...	1978	211399
a virus similar to human hepatitis b virus associated with hepatitis and hepatoma in woodchucks.	particles with properties similar to those associated with human hepatitis b were found in serum from woodchucks with chronic hepatitis and hepatocellular carcinoma. it is suggested that woodchuck hepatitis virus is a second member of a novel class of viruses represented by the human hepatitis b virus.	1978	212758
transmission of hepatitis b to the rhesus monkey. studies on the humoral and cell-mediated immune response.	the susceptibility of the rhesus monkey (macaca mulatta) to hepatitis b virus was enhanced by the induction of chronic infection with plasmodium inuei.	1978	101663
immune complexes of hepatitis b surface antigen in the pathogenesis of periarteritis nodosa. a study of seven necropsy cases.	in 7 unselected necropsy cases of clinically diagnosed periarteritis nodosa, the detection of hepatitis b surface antigen (hbsag) and hepatitis b core antigen (hbcag) in the cytoplasm and nuclei of hepatocytes indicated an ongoing infection with hepititis b virus (hbv). in all these cases histologic changes found in the liver varied from "minimal" to chronic aggressive hepatitis. in all the cases, deposits of hbsag, immunoglobulins, beta1c-globulin and c1q were detected in vascular lesions. that ...	1978	24342
[biological characteristics of influenza b viruses isolated during influenza b epidemics in 1976-1977].	comparative studies of the antigenic structure of influenza b viruses isolated in 1976-1977 and in previous years demonstrated one-way relationship of the hemagglutinin of b/76 viruses with that of b/72 viruses. antisera to new b/76 strains neutralized the hemagglutinating activity of all known reference influenza b virus strains beginning from 1972. influenza b/76 viruses were divided into two groups depending on complete or partial neutralization by antiserum b/hong kong/7/75. the study of the ...	1978	749340
antigens of hepatitis b virus: failure to detect hbeag on the surfaces of hbsag forms.	the particulate forms of hbsag were analysed for the presence of hbeag on their surfaces. by immunodiffusion analysis, anti-hbe did not form precipitin bands with the purified forms of hbsag and hyperimmune guinea pig antisera to these forms did not react with hbeag. lines of non-identity were observed between the hbeag determinants (e1 and e2) and the dane particles and filaments isolated from an hbeag-positive serum. finally, anti-hbe failed to precipitate the polymerase-positive subpopulation ...	1978	75946
oncogenicity of avian leukosis viruses of different subgroups and of mutants of sarcoma viruses.	leukosis viruses of seven subgroups were tested for oncogenicity in chickens susceptible to virus infection and to development of lymphoid leukosis (ll) tumors. all subgroup a viruses and the subgroup b virus tested produced a high incidence of ll and other related neoplasms. viruses of subgroup c and rav-61 of subgroup f produced a low level of ll. the rav-50 of subgroup d produced osteopetrosis. in these tests, the viruses of subgroup e and g and one virus of subgroup f were not pathogenic, po ...	1977	191400
comparative complement fixation and serum neutralization antibody titers to herpes simplex virus type 1 and herpesvirus simiae in macaca mulatta and humans.	the serological relationship of herpes simplex type 1 virus and herpesvirus simiae was studied. antibody titers to these viruses were determined in 163 macaca mulatta sera and 67 human sera by serum neutralization (sn) and complement fixation (cf) tests. both groups of sera were also tested by cf with envelope and capsid antigens of herpes simplex type 1. by sn, the majority of the monkeys and all of the humans had a higher titer to herpes simplex type 1 than to h. simiae. by cf, with crude anti ...	1977	192762
experimental carcinoma of liver in macaque monkeys exposed to diethylnitrosamine and hepatitis b virus.	the effects of treatments with diethylnitrosamine (dena) and hepatitis b virus (hbv) on macaque monkeys were investigated by virus serology and by light and electron microscopy. the experimental groups comprised 43 newborn or juvenile cynomolgus and rhesus monkeys of both sexes. hbv neither had a carcinogenic effect nor increased the oncogenic effect of dena. however, hbv given to juvenile primates before treatment with dena resulted in subsequent gross and microscopic alterations consistent wit ...	1977	198564
partial amino acid sequence of two major component polypeptides of hepatitis b surface antigen.	determination of the amino acid sequence of the immunogenic polypeptides of hepatitis b surface antigen may not only permit molecular localization of the distinct determinants a, d, and y but may also lead to the synthesis of a hapten useful in prophylactic immunization against hepatitis b virus infection. for this purpose, purified monotypic hepatitis b surface antigen of adw subtype was resolved into equal amounts of two major polypeptides (22,000 and 28,000 daltons) and up to six other minor ...	1977	266193
t-lymphocyte cytotoxicity to hbsag-coated target cells in hepatitis b virus infection.	the cytotoxic effect of peripheral lymphocytes on chicken red blood cells (chrbc) coated with purified hepatitis b surface antigen (hbsag) has been studied as an in vitro parameter of cell-mediated immunity in acute and chronic infection with hepatitis b virus. using this technique, the mean cytotoxic index of lymphocytes from patients with acute hepatitis b (29.13 +/- 20.88) was significantly higher than that obtained with lymphocytes from control subjects (6.53 +/- 3.75). only 33.3% of the pat ...	1977	304824
[rearing and management of chimpanzees for experimental infection with hepatitis b virus (author's transl)].	for the purpose of experimental infection with human hepatitis b virus, 14 chimpanzees (pan troglodytes) were delivered to the division of animal research, faculty of medicine, university of tokyo, tokyo. these chimps, 11 males and 3 females, born in the west africa, had been reared for two to six months. several days after delivery, they were anesthetized with ketalar in order to make clinical, bacteriological and parasitological examinations; it was found that one of them was in malnutrition, ...	1977	558103
viral type a and type b hepatitis: morphology, biology, immunology and epidemiology--a review.	viral hepatitis is one of the most serious infectious diseases in the united states and is of great concern to the public health agencies, hospitals and research laboratories. progress in our knowledge of this disease has been based on cooperation between specialists in many diverse scientific disciplines employing sophisticated scientific instruments and technics. close cooperation between clinical pathologists and clinicians is of great importance in diagnosis. biologic, immunologic, epidemiol ...	1976	218439
multiple testing for the detection of b virus antibody in specially handled rhesus monkeys after capture from virgin trapping grounds.	eight groups of rhesus monkeys totaling over 1,000 animals were captured in the virgin trapping grounds of jammu and kashmir, india. individual caging and special handling technics were utilized to prevent cross-contamination during capture, holding, and subsequent shipment to quarantine facilities in the united states. immediately following the arrival of the monkeys, 5 consecutive blood samples were obtained at approximately 2-wk intervals, and the sera were rested for neutralizing antibody ag ...	1976	177807
hepatitis a antigen isolated from liver and stool: immunologic comparison of antisera prepared in guinea pigs.	morphologically similar hepatitis a antigen particles (ha ag)3 have been detected in the stools of patients with type a hepatitis and in the livers of marmosets experimentally infected with hepatitis a virus. to investigate the humoral antibody responses to these antigens and to compare the immunologic properties of ha ag from these two sources, we immunized guinea pigs with either marmoset liver-derived ha ag or with human stool-derived ha ag in complete freund's adjuvant and measured their ant ...	1976	182882
development and chimpanzee testing of a vaccine against human hepatitis b.	highly purified hepatitis b virus surface antigen (australia antigen) purified by physical and chemical procedures from infected human plasma was used to prepare hepatitis b vaccine. the purified antigen was treated with formalin and the vaccine was tested exhaustively for safety by ordinary procedures and additionally in marmosets (for live hepatitis b virus). the vaccine was highly potent, inducing antibody in guinea pigs, grivet monkeys, and chimpanzees given three doses of vaccine containing ...	1976	817293
vaccine against human hepatitis b.	a highly purified and inactivated vaccine was made of hepatitis b virus surface antigen. the vaccine was tested exhaustively for safety by ordinary procedures and additionally in chimpanzees and marmosets. it was highly potent and induced antibody in guinea pigs, grivet monkeys, and chimpanzees after three doses of vaccine were given subcutaneously. chimpanzees given three doses of vaccine were protected against challenge with 1,000 chimpanzee-infectious doses of live human hepatitis b virus giv ...	1976	819667
progress report on the charles river breeding laboratories' free-ranging rhesus monkey breeding colony on key lois, florida.	the nucleus of a breeding colony of free-ranging rhesus monkeys (macaca mulatta) free from tuberculosis, herpes-b virus, shigellosis, and salmonellosis has been established on key lois, florida, usa. standardized procedures for trapping, quarantine, and shipping from the wild in india to the island have been established. the monkeys seem to have adapted well to the florida keys' climate. reproduction has proceeded according to expectations, and social groups have been formed with continual restr ...	1976	1271747
viral hepatitis, type b, in experimental animals.	evidence of natural infection with hepatitis b virus (hbv) in chimpanzees was followed by demonstration that this species provides a highly sensitive animal model system for experimental type b hepatitis. with rare exceptions, inoculation of sero-negative chimps with materials containing infectious hbv produces serologic evidence of infection including appearance of circulating hepatitis b surface antigen (hbs ag) and subsequently development of antibody to hbs ag and hepatitis b core antigen. s ...	1975	1181931
hepatitis b core antigen and antibody.	two distinct antigen-antibody systems are associated with the hepatitis b virus: the hepatitis b surface antigen (hbsag, australia antigen) and antibody (anti-hbs) and the recently characterized hepatitis b core antigen (hbcag) and antibody (anti-hbc, anti-core). hbsag is found in the serum of patients acutely or chronically infected with the hepatitis b virus (hbv) and is represented on electron microscopy of such serum as 20 nm spherical and tubular structures and as the surface component of t ...	1975	1204955
transmission of hepatitis b to the rhesus monkey.	the rhesus monkey does provide a suitable laboratory animal model for studying hepatitis b virus and for investigating various aspects of interaction between this infectious agent and the host. this species of non-human primate, however, offers a less sensitive animal model for hepatitis b infection than the chimpanzee.	1975	812744
hazards from simian herpes viruses: reactivation of skin lesions with virus shedding.	a new simian herpes virus with biological properties similar to herpes simplex and to simian "b" virus has been used as a model system for studying virus latency in dorsal root spinal sensory ganglia. following intradermal injection, virus is present in the skin lesions and corresponding ganglia only, during the acute stage of the disease. by organ-culture techniques, latent virus was rescued from ganglia up to 2 years later. no latent virus was ever found in skin organ cultures of the primar ...	1975	47078
multiple herpesvirus simiae isolation from a rhesus monkey which died of cerebral infarction.	a rhesus monkey housed in the new england regional primate research center for more than 4 yr died after an illness of 19 da. clinical signs included central nervous system involvement and ulcers on the labial mucosa. microscopically, the cause of death was established as multiple cerebral infarction. lesions characteristic of herpesvirus infections were not present in the brain nor in any other tissue; however, herpesvirus simiae was isolated from oral and anal swabs as well as from tongue and ...	1975	167229
the isolation of monkey b virus (herpesvirus simiae) from the trigeminal ganglia of a healthy seropositive rhesus monkey.		1975	169266
recovery of herpes simiae (b virus) from both primary and latent infections in rhesus monkeys.	the suspected ability of herpes simiae (b virus) to persist in a latent form has been confirmed in rhesus monkeys. the virus was recovered from primary oral lesions of 2 young monkeys and again, 6 months after disappearance of symptoms, from cultures of gasserian ganglia taken from the same individuals. b virus was identified by its effects in vivo and in vitro and in cross neutralization tests with antisera to reference b virus and herpes simplex virus. tests showed that the same virus was pres ...	1975	177038
humoral and cell-mediated immune responses to two hepatitis b virus antigens in guinea pigs.		1974	4413724
genetic recombination for antigenic markers of antigenically different strains of influenza b virus.	incorporation of trypsin in agar overlay or fluid maintenance media resulted in enhancement of plaquing efficiency and replication of influenza b viruses in primary chicken embryo fibroblasts. using this improved technique, recombination was attempted with two serologically distinct strains of influenza b virus, b/lee/40 and b/massachusetts/1/71. after mixed infection, two virus clones were selected and characterized in detail. hemagglutination inhibition and neuraminidase inhibition tests showe ...	1974	16789141
herpesvirus simiae infection in macaca radiata.		1973	4347671
characterization and separation of viral dna polymerase in mouse milk.	two dna polymerase with properties of viral rna-directed dna polymerase can be found in riii mouse milk. one enzyme is the polymerase of type-c viruses; this enzyme prefers manganese to magnesium with poly(ra).oligo(dt) as synthetic template, is inhibited by specific sera, and has an apparent molecular weight of 70,000. milk from balb/c and nih swiss mice contain a vast predominance of this type-c enzyme. the other dna polymerase from riii mouse milk prefers magnesium to manganese, is not inhibi ...	1973	4124683
virtual absence of infection with herpesvirus simiae in colony-reared rhesus monkeys (macaca mulatta), with a literature review on antibody prevalence in natural and laboratory rhesus populations.		1972	4334438
experimental infection of animals with influenzavirus types a and b.	the knowledge that domestic cats were susceptible to infection with freshly isolated a/hong kong/68 influenzavirus led to studies on the susceptibility of some other animal species to this virus, as well as to studies on the ability of egg-passaged hong kong virus and an asian virus to infect cats. the ability of a recent isolate of influenzavirus b to infect these animals was also studied. macaca radiata monkeys could be infected with fresh isolates of a/hong kong virus by intranasal instillati ...	1972	4196340
diagnosis and handling of b virus in a rhesus monkey (macaca mulatta).		1968	4300606
adsorption of mycoplasma pneumoniae to neuraminic acid receptors of various cells and possible role in virulence.	monkey, rat, and chicken tracheal epithelial cells, as well as monkey, rat, guinea pig, and chicken erythrocytes, adsorbed firmly to colonies of mycoplasma pneumoniae and m. gallisepticum. colonies of m. pulmonis also adsorbed erythrocytes but with less avidity than m. pneumoniae or m. gallisepticum; unlike the latter organisms, m. pulmonis did not adsorb tracheal epithelial cells. colonies of m. orale type 1 and m. orale type 3 adsorbed only chicken red cells. other mycoplasma species tested, i ...	1968	4183967
distribution area and natural hosts of latent viruses of monkeys. occurrence of simian vacuolating virus (sv40) and herpesvirus simiae in cynomolgus monkeys in indonesia.		1966	4381988
[cold hemagglutinins and anti-chicken antibodies during infections with influenza a and b virus].		1966	5973735
comparison of the pathogenesis of newcastle disease virus and influenza b virus in chicken embryos.		1960	14425334
enzymatic variants of influenza virus. ii. effect of environmental factors on enzymatic characteristics of a variant of influenza b virus.	the rate of elution of the variant virus from chicken rbc is progressively decreased as the temperature of incubation is increased above 25 degrees c. the activity of the parent virus, on the other hand, is increased as the temperature is increased up to 40 degrees c. the major cause of the decreased activity of the variant at temperatures above 2s degrees c. is an inhibition of the variant enzyme rather than its inactivation. the activity of the variant enzyme is stimulated in the presence of s ...	1958	13587849
development of resistance of influenza b virus to polysaccharides.	algal polysaccharide obtained from carrageenin protects 80 to 100 percent of chicken embryos against fatal infections with the lee strain of influenza virus. this report describes the rapid emergence of a stable variant of this virus which is resistant to the protective action of this polysaccharide.	1958	13615309
enzymatic variants of influenza virus. i. isolation and characterization of slowly reacting enzymatic variants of influenza b virus.	slowly reacting enzymatic variants of the lee strain of influenza b virus were isolated by the serial application of a technique which concentrated the fraction of the virus population obtained by slow elution followed by passage of this fraction at high dilution in chicken embryos. the variants were stable upon serial passage in chicken embryos and did not differ significantly from the parent virus in any of the characteristics tested other than those relating to the virus enzyme. enzymatically ...	1957	13439115
the influence of cortisone on experimental viral infection. iil effects on certain dynamics of influenza virus increase.	the administration of cortisone to chicken embryos infected with influenza b virus results in (a) an initial inhibition of viral synthesis and (b) an eventual increase in the final yield of virus attained. increased yields of virus are attained regardless of the number of viral particles in the infecting inoculum or the proportion of particles which are infective. changes in the distribution ratios of allantoic fluid and intramembrane virus are effected by cortisone only as the secondary result ...	1957	13481248
reproduction of influenza viruses; quantitative investigations with particle enumeration procedures on the dynamics of influenza a and b virus reproduction.	influenza a and b virus reproduction in the allantoic membrane of the intact chicken embryo was studied quantitatively with particle enumeration procedures. virus particles were enumerated on the basis of two independent properties; capacity to infect and to cause hemagglutination. the infective property of influenza b virus (lee) was even more unstable than that of influenza a virus (pr8). inactivation occurred at a constant logarithmic rate which was independent of the concentration of particl ...	1955	13263486
isolation of b virus (herpes group) from the central nervous system of a rhesus monkey.	while passaging a recently isolated strain of poliomyelitis virus through a rhesus monkey, another virus was procured from its central nervous system. after intracerebral inoculation, the virus produced meningoencephalitis in monkeys, cotton rats, hamsters, guinea pigs, and rabbits; after intracutaneous inoculation a necrotic skin lesion was produced in the monkey and rabbit and this was often followed by myelitis. the virus could also be passed in newborn mice less than 48 hours old and in chic ...	1954	13286422
effect of b virus (strain no.1) in the syrian hamster.		1952	12996750
the reversibility of the o-d type of influenza virus variation.	data are presented which enhance the idea that the influenza virus is an unstable agent. they indicate that the o-d type of variation is not a discontinuous mutation but rather is a reversible phenomenon. the o and the d forms of virus both appear to be inherent in the virus particle; the dominance of one or the other form seems to be subject to chance occurrences, but is influenced by the conditions under which the virus is propagated. the capacity of the o form of virus to agglutinate guinea p ...	1948	18858643
influenza virus infection in the hamster; a study of inapparent virus infection and virus adaptation.	a study of influenza virus infection in the hamster has yielded the following results: 1. two influenza a strains (ga. 47 and pr8) multiplied readily in the hamster lung, although no lung lesions were produced during six serial passages. on further passage both viruses abruptly acquired the capacity to produce pulmonary consolidation and death of the animals. 2. extracts of the lungs during the early passages contained complement-fixing antigen and infectious virus, as revealed by titration in m ...	1948	18881492
electrophoretic study of antiviral sera.	1. sera of animals immunized against japanese b encephalitis, venezuelan equine encephalomyelitis, and western equine encephalomyelitis viruses were fractionated by electrophoresis. 2. electrophoretic patterns of rabbit sera before and after immunization against japanese b virus showed no consistent change traceable to antibody formation. 3. to determine the antibody content, the electrophoretic fractions of the respective sera were mixed in varying dilutions with infected mouse brain suspension ...	1947	19871633
studies on the mechanism of adaptation of influenza virus to mice.	1. when strains of influenza a virus which have been isolated in chick embryos are introduced into the mouse lung, the virus multiplies readily and achieves initially a titer which is as high as is even obtained, even after repeated passage. the high initial titer of virus may be unaccompanied by any lethal or visible pathogenic effects; but with four or five mouse passages the agent becomes lethal in high titer and causes extensive pulmonary consolidation, though its capacity to multiply in the ...	1947	19871683
laboratory transmission of japanese b encephalitis virus by seven species (three genera) of north american mosquitoes.	in the present studies ten common species of western north american mosquitoes have been tested for their ability to act as vectors of japanese b encephalitis virus (see summary table xii). the strain of japanese b encephalitis virus which was used was adapted to direct mouse brain passage, probably a disadvantage, but no freshly isolated strain was available. of the ten species of mosquitoes tested, seven were demonstrated to be laboratory vectors. these seven species represent three genera (cu ...	1946	19871524
immunological relationships among central nervous system viruses.	from observations carried out with the viruses of russian spring-summer encephalitis, louping ill, w.e.e., and the japanese b, st. louis, and west nile types of encephalitis, the following facts and inferences have been derived. 1. russian encephalitis and louping ill viruses showed a close relationship by complement fixation, neutralization, and intraperitoneal cross-resistance tests. intracerebral cross-resistance tests, on the other hand, failed to reveal any connection between them. neither ...	1944	19871375
adsorption of influenza hemagglutinins and virus by red blood cells.	a number of experiments were performed on the adsorption of influenza hemagglutinins on chicken red blood cells, from which the following conclusions were drawn:- 1. when chicken red blood cells and preparations of influenza viruses were mixed together, the influenza hemagglutinins present were rapidly adsorbed onto the cells. after varying lengths of time, dependent on the conditions of the experiment, the adsorbed hemagglutinins began to elute from the cells. with the lee strain at 23 degrees ...	1942	19871229
studies on pseudorabies (infectious bulbar paralysis, mad itch : iii. the disease in the rhesus monkey, macaca mulatta.	in the monkey (m. mulatto) the virus of pseudorabies, pantropic in the rabbit, behaves as a strict neurotrope. infection, usually fatal, readily follows intracerebral and intracisternal inoculation of rabbit virus, and often intrasciatic inoculation; the symptomatology of the ensuing disease is described. in a limited number of experiments no infection resulted from intradermal, intramuscular or intravenous inoculation. nerve and glial cells are primarily attacked by the virus, but no cytologica ...	1936	19870482
acute ascending myelitis following a monkey bite, with the isolation of a virus capable of reproducing the disease.	a case of acute ascending myelitis which followed the bite of an apparently normal macacus rhesus monkey is described. the clinical course as well as the pathological changes has been studied and found to be suggestive of a virus cause for the disease. the absence of perivascular demyelinization removes the case from the realm of acute disseminated encephalomyelitis and establishes it more or less definitely as a primary acute infectious myelitis. an extremely important feature of the pathologic ...	1934	19870235