Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| impact of ring size and drug loading on the pharmacokinetics of a combination dapivirine-darunavir vaginal ring in cynomolgus macaques. | this work investigates the impact of vaginal ring size and drug loading on the in vitro release, safety, ease of fit, and pharmacokinetics in cynomolgus macaques of matrix-type silicone elastomer vaginal rings containing a combination of the non-nucleoside reverse transcriptase inhibitor dapivirine and the protease inhibitor darunavir. drug-free and drug-loaded vaginal rings having three different geometries were manufactured by reaction injection molding. in vitro drug release was assessed usin ... | 2018 | 30153490 |
| distinct biological phenotypes of marburg and ravn virus infection in macaques. | filoviruses are among the most pathogenic infectious agents known to human, with high destructive potential, as evidenced by the recent ebola virus epidemic in west africa. as members of the filovirus family, marburgviruses have caused similar devastating outbreaks, albeit with lower case numbers. in this study we compare the pathogenesis of ravn virus (ravv) and marburg virus (marv) strains angola, musoke, and ozolin in rhesus and cynomolgus macaques, the 2 nonhuman primate species most commonl ... | 2018 | 30215737 |
| generation and characterization of a high affinity anti-human fcrn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma igg concentration. | rozanolixizumab (ucb7665), a humanized high-affinity anti-human neonatal fc receptor (fcrn) monoclonal antibody (igg4p), has been developed to reduce pathogenic igg in autoimmune and alloimmune diseases. we document the antibody isolation and compare rozanolixizumab with the same variable region expressed in various mono-, bi- and trivalent formats. we report activity data for rozanolixizumab and the different molecular formats in human cells, fcrn-transgenic mice, and cynomolgus monkeys. rozano ... | 2018 | 30130439 |
| detection of complement activators in immune attack eyes after ips-derived retinal pigment epithelial cell transplantation. | to determine whether human induced pluripotent stem (ips) cell-derived retinal pigment epithelial (rpe) cells (ips-rpe) can express complement factors. | 2018 | 30128491 |
| persistent marburg virus infection in the testes of nonhuman primate survivors. | sexual transmission of filoviruses was first reported in 1968 after an outbreak of marburg virus (marv) disease and recently caused flare-ups of ebola virus disease in the 2013-2016 outbreak. how filoviruses establish testicular persistence and are shed in semen remain unknown. we discovered that persistent marv infection of seminiferous tubules, an immune-privileged site that harbors sperm production, is a relatively common event in crab-eating macaques that survived infection after antiviral t ... | 2018 | 30173956 |
| oocyte retrieval after heterotopic transplantation of ovarian tissue cryopreserved by closed vitrification protocol. | a device for closed vitrification was designed to reduce the risk of contamination and investigated on its efficacy for ovarian function recovery after cryopreservation and heterotopic transplantation. | 2018 | 30173352 |
| renal ischemia-reperfusion injury in a diabetic monkey model and therapeutic testing of human bone marrow-derived mesenchymal stem cells. | clinically, acute kidney injury (aki) episodes in diabetes mellitus (dm) patients are associated with a cumulative risk of developing end-stage renal disease. in this study, we asked whether the severity of aki induced by renal ischemia-reperfusion injury (iri) is more prominent in dm than in non-dm control using a cynomolgus monkey (macaca fascicularis) model. we also investigated whether human bone marrow-derived mesenchymal stem cells (hbm-mscs) infused via the renal artery could ameliorate r ... | 2018 | 30155487 |
| intrathecal delivery of human esc-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model. | nonhuman primate experimental autoimmune encephalomyelitis (eae) is a valuable model for multiple sclerosis, an inflammatory demyelinating disease in the central nervous system (cns). human embryonic stem cell-derived mesenchymal stem cells (emsc) are effective in treating murine eae. yet, it remains unknown whether the emsc efficacy is translatable to humans. here we induced a primate eae model in cynomolgus monkeys and delivered emsc in spheres (emscsp) to preserve the cell viability during lo ... | 2018 | 30131877 |
| novel fatty acyl apoe mimetic peptides have increased potency to reduce plasma cholesterol in mice and macaques. | ac-he18a-nh2 is a dual-domain apoe mimetic peptide that possesses the putative receptor binding domain from apoe (lrklrkrllr, denoted he; residues 141-150) covalently attached to lipid-associating peptide 18a. like apoe, ac-he18a-nh2 reduces plasma cholesterol in animal models and exhibits anti-inflammatory properties independent of its cholesterol-reducing effect. ac-he18a-nh2 has already undergone phase i clinical trials as a lipid-lowering agent. to explore the therapeutic potential more, we ... | 2018 | 30201630 |
| genetic diversity in the env v1-v2 region of proviral quasispecies from long-term controller mhc-typed cynomolgus macaques infected with shivsf162p4cy. | intra-host evolution of human immunodeficiency virus (hiv) and simian immunodeficiency virus (siv) has been shown by viral rna analysis in subjects who naturally suppress plasma viremia to low levels, known as controllers. however, little is known about the variability of proviral dna and the inter-relationships among contained systemic viremia, rate of reservoir reseeding and specific major histocompatibility complex (mhc) genotypes, in controllers. here, we analysed the proviral dna quasispeci ... | 2018 | 30311877 |
| aging results in iron accumulations in the non-human primate choroid of the eye without an associated increase in zinc, copper or sulphur. | we present further analyses of a previous experiment published in 2016 where the distribution, concentration and correlation of iron, zinc, copper and sulphur in the choroid of the eye in young and aged old world primates (macaca fascicularis) was studied with synchrotron x-ray fluorescence with a 2 μm resolution. the results indicate that iron accumulates in hotspots in the choroid with age with fluorescence intensity ranging from 2- to 7-fold (1002-3752 ppm) the mean level in the choroidal str ... | 2018 | 30306383 |
| komodo dragon predation on crab-eating macaques at the rinca island's visitor centre, indonesia. | we investigated the proportion of crab-eating macaques in the diet of komodo dragons and quantified the spatial habitat use between the species as a proxy for predation threat and in relation to prey availability due to ecotourism. in 2013, in loh buaya valley of rinca island, komodo national park, we conducted macroscopic identification of hairs, claws, dentition and osteological remains of consumed prey. for habitat use, we quantified the use of vertical strata by macaques through focal animal ... | 2018 | 30114686 |
| lead concentration in long-tailed macaque (macaca fascicularis) hair in kuala selangor, malaysia. | long-tailed macaque (macaca fascicularis) has the potential to be a good biological indicator for toxic exposure because they have an almost similar physiology and behaviour to humans. the objective of this study is to determine the concentration of lead (pb) in hair samples of long-tailed macaques which were found in and out of the kuala selangor nature park (ksnp) area. the hypothesis is long-tailed macaques that live in the anthropogenic area (outside ksnp) may be exposed to high levels of le ... | 2018 | 30112148 |
| an adapted isotope dilution 1h-13c heteronuclear single-quantum correlation (id-hsqc) for rapid and accurate quantification of endogenous and exogenous plasma glucose. | a wide variety of methods, such as enzymatic methods, lc-ms, and lc-ms/ms, are currently available for the concentration determination of plasma glucose in studies of diabetes, obesity, exercise, etc. however, these methods rarely discriminate endogenous and exogenous glucose in plasma. a novel nmr strategy for discriminative quantification of the endogenous and exogenous glucose in plasma has been developed using an adapted isotope dilution 1h-13c heteronuclear single-quantum correlation (id-hs ... | 2018 | 30054692 |
| acute-phase cd4+ t cell responses targeting invariant viral regions are associated with control of live attenuated simian immunodeficiency virus. | we manipulated sivmac239δnef, a model of major histocompatibility complex (mhc)-independent viral control, to evaluate characteristics of effective cellular responses mounted by mauritian cynomolgus macaques (mcms) that express the m3 mhc haplotype, which has been associated with poor control of pathogenic simian immunodeficiency virus (siv). we created sivδnef-8x to test the hypothesis that effective siv-specific t cell responses targeting invariant viral regions can emerge in the absence of im ... | 2018 | 30111562 |
| effects of gs-9876, a novel spleen tyrosine kinase inhibitor, on platelet function and systemic hemostasis. | spleen tyrosine kinase (syk) mediates signal transduction in multiple hematopoietic cells, including platelets. syk signals downstream of immunoreceptors and syk inhibition may ameliorate disease pathology in multiple autoimmune disorders; however, the impact of syk inhibition in platelets and its potential relevance to bleeding is not fully understood. these studies evaluated the effect of an oral syk inhibitor, gs-9876, on platelets in vitro and in vivo, and the impact of gs-9876 plus non-ster ... | 2018 | 30172129 |
| genetic variants of glutathione s-transferase gstt1 and gstt2 in cynomolgus macaques: identification of gstt substrates and functionally relevant alleles. | glutathione s-transferase (gst) is a family of important drug-metabolizing enzymes, conjugating endogenous and exogenous compounds. genetic polymorphisms result in the inter-individual variability of gst activity in humans. especially, human gstt1 and gstt2 null alleles are associated with toxicity and various cancers derived from chemicals. cynomolgus macaque, a nonhuman primate species widely used in drug metabolism studies, has molecular and enzymatic similarities of gsts to the human ortholo ... | 2018 | 30169019 |
| ontogenetic changes to muscle architectural properties within the jaw-adductor musculature of macaca fascicularis. | changes to soft- and hard-tissue components of the masticatory complex during development can impact functional performance by altering muscle excursion potential, maximum muscle forces, and the efficiency of force transfer to specific bitepoints. within macaca fascicularis, older individuals exploit larger, more mechanically resistant food items and more frequently utilize wide-gape jaw postures. we therefore predict that key architectural and biomechanical variables will scale during ontogeny ... | 2018 | 30168867 |
| nonhuman primate model of persistent erectile and urinary dysfunction following radical prostatectomy: feasibility of minimally invasive therapy. | persistent urinary incontinence (ui) and/or erectile dysfunction (ed) occur in 30-50% of post-radical prostatectomy patients regardless of nerve sparing approaches. identification of potential treatment options for these patients will require testing in an animal model that develops these chronic conditions. the objective was to characterize a nonhuman primate (nhp) model of persistent post-prostatectomy ed and ui and then test the feasibility of periurethral injection of the chemokine cxcl-12. | 2018 | 30168617 |
| dna-based determination of ancestry in cynomolgus macaques (macaca fascicularis). | interest in the genetic composition of cynomolgus macaques (macaca fascicularis) has increased due to the rising demand for nhp models in human biomedical research. significant genetic differences among regional populations of cynomolgus macaques can confound interpretations of research results because they do not solely reflect differences in experimental treatment effects. therefore, the common origin of cynomolgus macaques used as research subjects should be verified by using region-specific ... | 2018 | 30165920 |
| comparison of cellular localisation of the ca2+ -binding proteins calbindin, calretinin and parvalbumin in the retina of four different macaca species. | ca2+ -binding proteins are differentially expressed in the nervous system; their functional role often remains unclear. this immunohistochemical study aimed at characterising and comparing the expression pattern of the ca2+ -binding proteins calbindin (calb), calretinin (calr) and parvalbumin (parv) in the retina of four species of macaque monkeys: macaca fascicularis (cynomolgus macaque), m. mulatta (rhesus macaque), m. thibetana (tibetan macaque) and m. fuscata (japanese macaque). calb was fou ... | 2018 | 30155916 |
| letter to the editor regarding "spontaneous findings in the eyes of cynomolgus monkeys ( macaca fascicularis) of mauritian origin" by woicke et al. ( toxicol pathol 46, 273-282, 2018). | 2018 | 30092740 | |
| effects of unilateral electroacupuncture on bilateral proprioception in a unilateral anterior cruciate ligament injury model. | background anterior cruciate ligament (acl) injury can cause knee proprioception degeneration, on which the electroacupuncture (ea) treatment has a definite effect. however, it is still not clear whether conducting ea intervention on the injured side can promote bilateral proprioception recovery. material and methods we randomly selected 6 of 9 normal cynomolgus monkeys to develop unilateral acl injury models via arthroscopy. all knees were divided into 5 groups: the normal control (nc) group, i ... | 2018 | 30082677 |
| mucosal antibody responses to vaccines targeting siv protease cleavage sites or full-length gag and env proteins in mauritian cynomolgus macaques. | hiv mutates rapidly and infects cd4+ t cells, especially when they are activated. a vaccine targeting conserved, essential viral elements while limiting cd4+ t cell activation could be effective. learning from natural immunity observed in a group of highly hiv-1 exposed seronegative kenyan female sex workers, we are testing a novel candidate hiv vaccine targeting the 12 viral protease cleavage sites (pcss) (the pcs vaccine), in comparison with a vaccine targeting full-length gag and env (the gag ... | 2018 | 30153293 |
| vaccine-mediated induction of an ebolavirus cross-species antibody binding to conserved epitopes on the glycoprotein heptad repeat 2/membrane-proximal external junction. | the membrane-proximal external regions (mper) of the human immunodeficiency virus envelope glycoprotein (gp) generate broadly reactive antibody responses and are the focus of vaccine development efforts. the conservation of amino acids within filovirus gp heptad repeat region (hr)2/mper suggests that it may also represent a target for a pan-filovirus vaccine. we immunized a cynomolgus macaque against ebola virus (ebov) using a deoxyribonucleic acid/adenovirus 5 prime/boost strategy, sequenced me ... | 2018 | 30137549 |
| dosikit, a new immunoassay for fast radiation biodosimetry of hair and blood samples. | dosikit is a field radiation biodosimetry immunoassay for fast triage of individuals exposed to external total-body or partial-body irradiation (tbi or pbi). assay proof-of-concept based on γ-h2ax analysis of human blood samples has been previously described as a promising tool for rapid assessment of tbi. here, we report on the performance of the assay for pbi based on an analysis of hair follicles irradiated with a 137cs gamma-ray source, at doses ranging from 0 to 20 gy and dose rates ranging ... | 2018 | 30074847 |
| mycobacterium tuberculosis erdman infection of cynomolgus macaques of chinese origin. | nearly one-third of the population worldwide is estimated to have latent tuberculosis infection (ltbi), which represents a vast reservoir for a constant source of tuberculosis (tb) transmission. it has been suggested that cynomolgus macaques are less susceptible to mycobacterium tuberculosis (m.tb) infection than rhesus macaques, we examined m.tb infection of chinese cynomolgus macaques. | 2018 | 30069358 |
| superior efficacy of hi-6 dimethanesulfonate over pralidoxime methylsulfate against russian vx poisoning in cynomolgus monkeys (macaca fascicularis). | organophosphorus nerve agents still represent a serious risk to human health. in the french armed forces, the current emergency treatment against op intoxications is a fully licensed wet-dry dual-chambered autoinjector (ineurope ®), that contains pralidoxime methylsulfate (2-pam) to reactivate inhibited acetylcholinesterase (ache), atropine sulfate (as) and avizafone chlorhydrate (avz). while this treatment is effective against several of the known nerve agents, it shows little efficacy against ... | 2018 | 30218682 |
| safety profile after prolonged c3 inhibition. | the central component of the complement cascade, c3, is involved in various biological functions, including opsonization of foreign bodies, clearance of waste material, activation of immune cells, and triggering of pathways controlling development. given its broad role in immune responses, particularly in phagocytosis and the clearance of microbes, a deficiency in complement c3 in humans is often associated with multiple bacterial infections. interestingly, an increased susceptibility to infecti ... | 2018 | 30217791 |
| effect of provisioning on the temporal variation in the activity budget of urban long-tailed macaques (macaca fascicularis) in west sumatra, indonesia. | we studied the behavioral ecology of provisioned long-tailed macaques (macaca fascicularis) in padang, west sumatra, indonesia, to examine how temporal changes in food provisioning within a day affect macaque activity. we conducted a field survey from october 2015 to january 2016 at two different sites: gunung meru (gm) and gunung padang (gp), where macaques receive high and low provisioning, respectively. the time budgets of macaques significantly differed between study groups. at gm, macaques ... | 2018 | 30212833 |
| comparison of inhibitory neuromuscular transmission in the cynomolgus monkey ias and rectum: special emphasis on differences in purinergic transmission. | inhibitory neuromuscular transmission (nmt) was compared in the internal anal sphincter (ias) and rectum of the cynomolgus monkey, an animal with high gene sequence identity to humans. nitrergic nmt was present in both muscles while purinergic nmt was limited to the rectum and vipergic nmt to the ias. the profile for monkey ias more closely resembles humans than rodents. in both muscles, sk3 channels were localized to pdgfrα+ cells that were closely associated with nnos+ /vip+ nerves. gene expre ... | 2018 | 30198065 |
| metabolism of c-met kinase inhibitors containing quinoline by aldehyde oxidase, electron donating, and steric hindrance effect. | some quinoline-containing c-met kinase inhibitors are aldehyde oxidase (ao) substrates. 3-substituted quinoline triazolopyridine analogs were synthesized to understand the electron-donating and steric hindrance effects on ao-mediated metabolism. metabolic stability studies for these quinoline analogs were carried out in liver cytosol from mice, rats, cynomolgus monkeys, and humans. several 3-n-substituted analogs were found to be unstable in monkey liver cytosolic incubations (half-life, <10 min ... | 2018 | 30209037 |
| comparative safety assessments of the biosimilar apz001 and erbitux in pre-clinical animal models. | to evaluate the toxicity of erbitux as well as its biosimilar apz001 antibody (apz001) in pre-clinical animal models including mice, rabbits and cynomolgus monkeys. | 2018 | 30208131 |
| [establishment of retinal disease models using non-human primates and its strategy for drug discovery]. | retinal diseases such as glaucoma, diabetic retinopathy, age-related macular degeneration and retinitis pigmentosa are the major causes of blindness. however, these pathological mechanisms remain to be elucidated, and development of new therapeutic agents has been desired. a large number of experimental animal models using rodents (rats and mice) have been used for the evaluations of the pathogenesis and novel therapeutic candidates in retinal diseases. however, the anatomy of the retina in rode ... | 2018 | 30185732 |
| a method for expansion of t cells from cynomolgus monkey (macaca fascicularis). | t cells have been successfully applied to cancer immunotherapy. however, a challenge is an expansion of t cells from cynomolgus monkey, which is a valuable non-human primate model for t cell therapy transferring to the clinic. here, we compared several strategies to expand cynomolgus monkey t cell and developed an appropriate method. our study demonstrated that 100 ng/ml cd3 mab + 1% pha+ 1000 u/ml il2 therapy significantly expanded peripheral blood cd3+ t cells without compromising t cell pheno ... | 2018 | 30112696 |
| minimal physiologically-based pharmacokinetic model to investigate the effect of ph dependent fcrn affinity and the endothelial endocytosis on the pharmacokinetics of anti-vegf humanized igg1 antibody in cynomolgus monkey. | in this study, we developed a first minimal physiologically-based pharmacokinetic (mpbpk) model to investigate the complex interaction effects of endocytosis rate/fcrn binding affinity at both acidic/physiological ph on the pharmacokinetics (pk) of the anti-vegf igg1 antibodies. the data used in this study were the pk of the native igg and humanized anti-vegf igg1 antibodies with a wide range fcrn-binding at both acidic and physiological ph in the cynomolgus monkey. the basic structure of the de ... | 2018 | 30248389 |
| age-related nomograms of serum anti-mullerian hormone levels in female monkeys: comparison of rhesus (macaca mulatta) and cynomolgus (macaca fascicularis) monkeys. | amh is regarded as a promising predictor for ovarian reserve in humans and non-human primate, and widely used in human medicine to predict ovarian response to gonadotropin, menopause and premature ovarian failure. however, large data set on the range of amh levels in nonhuman primates is still scarce, which limited its applications largely. in this study, age-related amh nomograms of rhesus (macaca mulatta) and cynomolgus (macaca fascicularis) were produced and compared. 219 rhesus and 529 cynom ... | 2018 | 30243886 |
| development of a bite®-mediated cd8+ cytotoxic t-lymphocyte activity assay to assess immunomodulatory potential of drug candidates in cynomolgus macaque. | the immunotoxic potential of drug candidates is assessed through the examination of results from a variety of studies and endpoints. while the functional assessment of cd8+ cytotoxic t-lymphocytes (ctl) is well-characterized in the clinic, the lack of a robust macaque ctl functional assay has been an important hurdle in evaluating and accurately quantifying cell-mediated cd8+ t-cell effector responses in the nonclinical setting. this paper describes the development of an assay to measure ctl act ... | 2018 | 30241454 |
| preexisting simian immunodeficiency virus infection increases susceptibility to tuberculosis in mauritian cynomolgus macaques. | tuberculosis (tb), caused by mycobacterium tuberculosis, is the leading cause of death among human immunodeficiency virus (hiv)-positive patients. the precise mechanisms by which hiv impairs host resistance to a subsequent m. tuberculosis infection are unknown. we modeled this coinfection in mauritian cynomolgus macaques (mcm) using simian immunodeficiency virus (siv) as an hiv surrogate. we infected seven mcm with sivmac239 intrarectally and 6 months later coinfected them via bronchoscope with ... | 2018 | 30224552 |
| system for on- and off-axis volumetric oct imaging and ray tracing aberrometry of the crystalline lens. | we present a new in vitro instrument for measuring shape and wavefront aberrations of the primate crystalline lens, both on- and off-axis, while simulating accommodation with a motorized lens stretching system. the instrument merges spectral domain optical coherence tomography (sd-oct) imaging and ray tracing aberrometry using an approach that senses wavefront aberrations of the lens with the oct probing beam. accuracy and repeatability of aberration measurements were quantified. preliminary exp ... | 2018 | 30338159 |
| cigarette smoke and hiv synergistically affect lung pathology in cynomolgus macaques. | in the era of combined antiretroviral therapy (cart), lung diseases such as chronic bronchitis (cb) and chronic obstructive pulmonary disease (copd) are common among persons living with hiv (plwh), particularly smokers. although smoking is highly prevalent among plwh, hiv may be an independent risk factor for lung diseases; however, the role of hiv and cigarette smoke (cs) and their potential interaction in the development of chronic lung diseases among plwh has not been delineated. to investiga ... | 2018 | 30277472 |
| the pituitary gland is a novel major site of action of metformin in non-human primates: a potential path to expand and integrate its metabolic actions. | biguanides are anti-hyperglycaemic agents used to treat diabetes by acting primarily on the liver, inhibiting hepatic gluconeogenesis. however, biguanides may target other key metabolic tissues to exert beneficial actions. as the "master endocrine gland", the pituitary is a true homeostatic sensor that controls whole body homeostasis and metabolism by integrating central and peripheral signals. however, whether the pituitary is a primary site of biguanides action in normal adult humans/primates ... | 2018 | 30205369 |
| comparison of efficacy and toxicity between botulinum toxin subtypes a1 and a2 in cynomolgus macaques. | botulinum toxin type a (subtype a1) is used as therapeutic agent for some neurological disorders causing spasticity. the toxin products have an upper dosage limit, and their adverse events, such as side effects of diffusion following high-dose administration, have become serious issues. therefore, a preparation with greater therapeutic efficacy at lower dosages and less diffusion in the body is desired. we have attempted to produce neurotoxin derived from subtype a2 (a2ntx), which has a differen ... | 2018 | 30193802 |
| replication deficient human adenovirus vector serotype 19a/64: immunogenicity in mice and female cynomolgus macaques. | the human adenovirus type 19a/64 (had19a) is a rare serotype in the human population that transduces human dendritic cells (dcs) and human muscle cells more efficiently than the well-characterized human adenovirus type 5 (had5). to further characterize the potential of this vector as a vaccine we designed replication deficient had19a, had5 and mva vectors expressing a papillomavirus (pv) antigen fused to the human mhc class ii associated invariant chain t cell adjuvant (hii) and investigated the ... | 2018 | 30190120 |
| profiling the airway in the macaque model of tuberculosis reveals variable microbial dysbiosis and alteration of community structure. | the specific interactions of mycobacterium tuberculosis (mtb), the causative agent of tuberculosis (tb), and the lung microbiota in infection are entirely unexplored. studies in cancer and other infectious diseases suggest that there are important exchanges occurring between host and microbiota that influence the immunological landscape. this can result in alterations in immune regulation and inflammation both locally and systemically. to assess whether mtb infection modifies the lung microbiome ... | 2018 | 30301469 |
| serum anti-mullerian hormone predicts ovarian response in (macaca fascicularis) monkeys | amh as a promising predictor of ovarian response has been studied extensively in women undergoing assisted reproductive technology treatment, but little is known about its prediction value in monkeys undergoing ovarian stimulation. in the current study, a total of 380 cynomolgus monkeys ranging from 5 to 12 years received 699 ovarian stimulation cycles. serum samples were collected for amh measure with enzyme-linked immunosorbent assay. it was found that serum amh levels were positive correlated ... | 2018 | 30300541 |
| ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies. | despite several clinical trials implemented, no antiviral drug could demonstrate efficacy against ebola virus. in non-human primates, early initiation of polymerase inhibitors favipiravir and remdesivir improves survival, but whether they could be effective in patients is unknown. here we analyze the impact of antiviral therapy by using a mathematical model that integrates virological and immunological data of 44 cynomolgus macaques, left untreated or treated with favipiravir. we estimate that f ... | 2018 | 30275474 |
| enhanced neutralizing antibody response induced by inactivated enterovirus 71 in cynomolgus monkeys. | enterovirus 71 (ev71) is a major etiological agent of various public health issues, particularly in the asia-pacific region. ev71 causes hand-foot-and-mouth disease (hfmd) and is associated with serious neurological disorders in young children. a formalin-inactivated ev71 candidate vaccine (kcdc-hfmdv1-ev71) based on the c4 subgenotype was previously developed and confirmed to be a potential candidate vaccine for prevention of ev71 infection in mice. in this study, an inactivated ev71 vaccine wa ... | 2018 | 30278051 |
| mass spectrometry-based identification and whole-genome characterisation of the first pteropine orthoreovirus isolated from monkey faeces in thailand. | the pteropine orthoreovirus (prv) was isolated from monkey (macaca fascicularis) faecal samples collected from human-inhabited areas in lopburi province, thailand. these samples were initially obtained to survey for the presence of hepatitis e virus (hev). | 2018 | 30332986 |
| a pre-clinical quantitative model predicts the pharmacokinetics/pharmacodynamics of an anti-bdca2 monoclonal antibody in humans. | biib059 is a novel humanized monoclonal antibody (mab) that is currently under development for the treatment of systemic lupus erythematosus and cutaneous lupus erythematosus. biib059 is targeted against the blood dendritic cell antigen 2 (bdca2), a receptor exclusively expressed on the surface of plasmacytoid dendritic cells (pdcs). herein, we utilized pre-clinical pharmacokinetic (pk) and pharmacodynamic (pd) data to develop a non-human primate (nhp) model and to address whether the nhp model ... | 2018 | 30377889 |
| evaluation of deuterium-labeled jnj38877605: pharmacokinetic, metabolic, and in vivo antitumor profiles. | c-met inhibitor jnj38877605 has proven curative as an antitumor agent, while its clinical study was terminated due to renal toxicity. it was reported that the renal toxicity was caused by the poor solubility of its aldehyde oxidase (ao) metabolites. therefore, blocking ao oxidation of jnj38877605 might diminish the toxic metabolites and overcome the renal toxicity. compound 3, the ao metabolic site deuterated jnj38877605, was then synthesized as the target molecule. in vitro monkey liver s9 frac ... | 2018 | 30284817 |
| proceedings of the 2018 national toxicology program satellite symposium. | the 2018 annual national toxicology program satellite symposium, entitled "pathology potpourri," was held in indianapolis, indiana, at the society of toxicologic pathology's 37th annual meeting. the goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. this article presents summaries of the speakers' talks along with select images that were used by the audience for voting and discussion. various lesions and other topics covered during the ... | 2018 | 30282530 |
| a safety study of newly generated anti-podoplanin-neutralizing antibody in cynomolgus monkey (macaca fascicularis). | hematogenous metastases are enhanced by platelet aggregation induced by tumor cell-platelet interaction. podoplanin is a key molecule to enhance the platelet aggregation and interacts with c-type lectin-like receptor 2 (clec-2) on platelet via plag domains. our previous reports have shown that blocking podoplanin binding to platelets by neutralizing antibody specific to plag4 domain strongly reduces hematogenous metastasis. however, podoplanin is expressed in a variety of normal tissues such as ... | 2018 | 30279963 |
| high resolution hard x-ray 3d mapping of a macaca fascicularis eye: a feasibility study without contrast agents. | several complementary methods able to visualize the internal structures of eyes are used in the clinical practice in the diagnosis of pathologies affecting a specific zone of the eye. despite the significant technological progress, the visualization of the entire eyeball at micrometric resolution is yet an unsolved task both in clinical diagnostics and in laboratory research. with this respect, high resolution 3d images of the eyeball would be extremely useful, in the study of various pathologie ... | 2018 | 30278983 |
| cynomolgus monkeys (macaca fascicularis) experimentally and naturally infected with hepatitis e virus: the bone marrow as a possible new viral target. | hepatitis e virus (hev) transmission through infected blood and blood products has already been described. however, little is known about the bone marrow (bm) as source of hev infection. our study aimed to investigate the presence of hev antigen (ag) and histological changes in bm of cynomolgus monkeys (macaca fascicularis) experimentally and naturally infected with hev. four cynomolgus monkeys with acute, and two with chronic hepatitis e ─ after immunosuppressive therapy with tacrolimus ─ were ... | 2018 | 30278075 |
| inhibition of catechol-o-methyltransferase in the cynomolgus monkey by opicapone after acute and repeated administration. | the aim of the study was to clarify the dose response for inhibition of catechol-o-methyltransferase (comt) by opicapone, a third generation comt inhibitor, after acute and repeated administration to the cynomolgus monkey with pharmacokinetic evaluation at the higher dose. | 2018 | 30290160 |
| tissue physiology of cynomolgus monkeys: cross-species comparison and implications for translational pharmacology. | we previously performed a comparative assessment of tissue-level vascular physiological parameters in mice and rats, two of the most commonly utilized species in translational drug development. the present work extends this effort to non-human primates by measuring tissue- and organ-level vascular volumes (vv), interstitial volumes (vi), and blood flow rates (q) in cynomolgus monkeys. these measurements were accomplished by red blood cell labeling, extracellular marker infusion, and rubidium chl ... | 2018 | 30298434 |
| the mevalonate pathway is a druggable target for vaccine adjuvant discovery. | motivated by the clinical observation that interruption of the mevalonate pathway stimulates immune responses, we hypothesized that this pathway may function as a druggable target for vaccine adjuvant discovery. we found that lipophilic statin drugs and rationally designed bisphosphonates that target three distinct enzymes in the mevalonate pathway have potent adjuvant activities in mice and cynomolgus monkeys. these inhibitors function independently of conventional "danger sensing." instead, th ... | 2018 | 30270039 |
| safe and effective superoxide dismutase 1 silencing using artificial microrna in macaques. | amyotrophic lateral sclerosis (als) is a fatal neurological disease caused by degeneration of motor neurons leading to rapidly progressive paralysis. about 10% of cases are caused by gain-of-function mutations that are transmitted as dominant traits. a potential therapy for these cases is to suppress the expression of the mutant gene. here, we investigated silencing of sod1, a gene commonly mutated in familial als, using an adeno-associated virus (aav) encoding an artificial microrna (mirna) tha ... | 2018 | 30381409 |
| molecular and functional characterization of n-acetyltransferases nat1 and nat2 in cynomolgus macaque. | arylamine n-acetyltransferases (nats) are drug-metabolizing enzymes essential for the metabolism of endogenous substrates and xenobiotics, and their molecular characteristics have been extensively investigated in humans, but not in cynomolgus macaques, nonhuman primate species important for drug metabolism studies. in this study, cynomolgus nat1 and nat2 cdnas were isolated from livers. nat1 and nat2 were characterized by molecular analyses and drug-metabolizing assays. a total of 9 transcript v ... | 2018 | 30358977 |
| aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects. | the objective of this study was to determine whether estrogen could be formed locally in the coronary arteries. | 2018 | 30358714 |
| current status of uterus transplantation and approaches for future clinical application in japan. | uterus transplantation (utx) has become an alternative to gestational surrogacy and adoption for women with uterine factor infertility (ufi). brännström et al achieved the first human delivery after utx in 2014, and to date a total of 8 babies have been born after utx from living donors. this outcome has attracted much attention worldwide, and many countries are now preparing for utx. there are an estimated 60,000 women of reproductive age with ufi in japan, and these patients cannot have biolog ... | 2018 | 30343882 |
| improved macaca fascicularis gene annotation reveals evolution of gene expression profiles in multiple tissues. | macaca fascicularis (m. fascicularis) is a primate model organism that played important role in studying human health. it is vital to better understand the similarity and differences of gene regulation between m. fascicularis and human. current comparative study of gene regulation between the two species are limited by low quality of gene annotation and lack of regulatory element data on m. fascicularis genome. | 2018 | 30382841 |
| gene expression dataset for whole cochlea of macaca fascicularis. | macaca fascicularis is a highly advantageous model in which to study human cochlea with regard to both evolutionary proximity and physiological similarity of the auditory system. to better understand the properties of primate cochlear function, we analyzed the genes predominantly expressed in m. fascicularis cochlea. we compared the cochlear transcripts obtained from an adult male m. fascicularis by macaque and human genechip microarrays with those in multiple macaque and human tissues or cells ... | 2018 | 30349143 |
| lymph nodes are sites of prolonged bacterial persistence during mycobacterium tuberculosis infection in macaques. | tuberculosis is commonly considered a chronic lung disease, however, extrapulmonary infection can occur in any organ. even though lymph nodes (ln) are among the most common sites of extrapulmonary mycobacterium tuberculosis (mtb) infection, and thoracic lns are frequently infected in humans, bacterial dynamics and the effect of mtb infection in ln structure and function is relatively unstudied. we surveyed thoracic lns from mtb-infected cynomolgus and rhesus macaques analyzing pet ct scans, bact ... | 2018 | 30383808 |
| molecular analysis of two different mrsa clones st188 and st3268 from primates (macaca spp.) in a united states primate center. | methicillin-resistant staphylococcus aureus (mrsa) were identified in macaques, their environmental facility, and nasal cultures of personnel from the washington national primate research center [wanprc] and included mrsa st188 sccmec iv and mrsa st3268 sccmec v. the aim of the current study was to determine the carriage of virulence genes, antibiotic resistance genes, and other characteristics of the primate mrsa isolates to determine if there were any obvious differences that would account for ... | 2018 | 30356855 |
| establishment of retinal degeneration model in rat and monkey by intravitreal injection of sodium iodate. | animal models play critical roles in studies of the etiology and therapy of retinal degeneration (rd). | 2018 | 30421676 |
| a long-lived il-2 mutein that selectively activates and expands regulatory t cells as a therapy for autoimmune disease. | susceptibility to multiple autoimmune diseases is associated with common gene polymorphisms influencing il-2 signaling and treg function, making treg-specific expansion by il-2 a compelling therapeutic approach to treatment. as an in vivo il-2 half-life enhancer we used a non-targeted, effector-function-silent human igg1 as a fusion protein. an il-2 mutein (n88d) with reduced binding to the intermediate affinity il-2rβγ receptor was engineered with a stoichiometry of two il-2n88d molecules per i ... | 2018 | 30446251 |
| experimental co-transmission of simian immunodeficiency virus (siv) and the macaque homologs of the kaposi sarcoma-associated herpesvirus (kshv) and epstein-barr virus (ebv). | macaque rfhv and lcv are close homologs of human kshv and ebv, respectively. no experimental model of rfhv has been developed due to the lack of a source of culturable infectious virus. screening of macaques at the washington national primate research center detected rfhv in saliva of siv-infected macaques from previous vaccine studies. a pilot experimental infection of two naïve juvenile pig-tailed macaques was initiated by inoculation of saliva from siv-infected pig-tailed and cynomolgus macaq ... | 2018 | 30444879 |
| cytochrome p450 1a1, 2c9, 2c19, and 3a4 polymorphisms account for interindividual variability of toxicological drug metabolism in cynomolgus macaques. | cytochromes p450 (p450s) and their genetic variants in humans are important drug-metabolizing enzymes partly accounting for interindividual variations in drug metabolism and toxicity. however, these genetic variants in p450s have not been fully investigated in cynomolgus macaques, a nonhuman primate species widely used in toxicological studies. in this study, genetic variants found in cynomolgus cyp1a1, cyp2c9 (formerly cyp2c43), cyp2c19 (cyp2c75), and cyp3a4 (cyp3a8) were assessed on functional ... | 2018 | 30412386 |
| immune-mediated systemic vasculitis as the proposed cause of sudden-onset sensorineural hearing loss following lassa virus exposure in cynomolgus macaques. | lassa virus (lasv) causes a severe, often fatal hemorrhagic disease in regions in africa where the disease is endemic, and approximately 30% of patients develop sudden-onset sensorineural hearing loss after recovering from acute disease. the causal mechanism of hearing loss in lasv-infected patients remains elusive. here, we report findings after closely examining the chronic disease experienced by surviving macaques assigned to lasv exposure control groups in two different studies. all nonhuman ... | 2018 | 30377282 |
| implicit preference for human trustworthy faces in macaque monkeys. | it has been shown that human judgements of trustworthiness are based on subtle processing of specific facial features. however, it is not known if this ability is a specifically human function, or whether it is shared among primates. here we report that macaque monkeys (macaca mulatta and macaca fascicularis), like humans, display a preferential attention to trustworthiness-associated facial cues in computer-generated human faces. monkeys looked significantly longer at faces categorized a priori ... | 2018 | 30375399 |
| choroid changes in vortex vein-occluded monkeys. | to determine acute and chronic choroidal vascular changes after vortex vein occlusion in monkeys. | 2018 | 30364268 |
| intravenous toxicity and toxicokinetics of an hdl mimetic, fx-5a peptide complex, in cynomolgus monkeys. | fx-5a peptide complex (fx-5a), a high density lipoproteins (hdl) mimetic, has been shown to reduce atherosclerosis. the safety and toxicokinetics of fx-5a administered iv by 30 min infusion at 8, 25 or 75 mg/kg body weight or vehicle, once every other day for 27 days, were assessed in cynomolgus monkeys. the fx-5a was well tolerated at all doses. at the highest dose, there were statistically significant effects on hematology and clinical chemistry parameters that were considered non-adverse. dos ... | 2018 | 30359697 |
| cathepsin k inhibition preserves compressive load in lumbar vertebrae of osteoporotic monkeys. | anti-resorptive drugs treat bone loss by blocking osteoclast activity through a variety of mechanisms of action. once significant bone loss has occurred, the ability to restore biomechanical function may differ based on the drug chosen. to assess this question, bisphosphonate (alendronate, aln) and cathepsin k inhibitor (mk-0674, catki) were employed in treatment mode to compare the relative changes to cancellous bone microstructure and mechanical properties in ovariectomized (ovx) cynomolgus mo ... | 2018 | 30406161 |
| evaluation of a potential clinical significant drug-drug interaction between digoxin and bupropion in cynomolgus monkeys. | a three-period digoxin-bupropion drug-drug interaction study was performed in cynomolgus monkeys to assess the effect of bupropion and its metabolites on digoxin disposition. | 2018 | 30402714 |
| [establishment and evaluation of a triple-color human papillomavirus pseudovirion neutralization assay]. | objective: to establish a triple-color pseudovirion-based neutralization assay (pbna) and evaluate its capability of detecting immunogenicity of the sera generated by the immunization of hpv 9-valent vaccine. methods: hpv pseudovirus (psvs) 6/11/16/18/31/33/45/52/58 with the encapsidated fluorescence expressing red fluorescent plasmid n31-mchreey, green fluorescent n31-egfp or blue fluorescent n31-mtagbfp were generated. the concentration of hpv psvs and the infection titers of hpv psvs were det ... | 2018 | 30392324 |
| alterations in the spinal cord and ventral root after cerebral infarction in non-human primates. | cerebral infarction does not only cause focal injury in the ischemic site, but also secondary non-ischemic damage at the remote areas of nervous system associated with the primary focus. | 2018 | 30400121 |
| mhc-identical and transgenic cynomolgus macaques for preclinical studies. | cynomolgus macaques are useful experimental animals that are physiologically and genetically close to humans. we have developed two kinds of experimental usage of cynomolgus macaque: transplantation and disease models. first, we identified certain major histocompatibility complex (mhc) haplotypes including homozygotes and heterozygotes in cynomolgus macaques native to the philippines, because they have less polymorphism in the mhc than that in other origins such as vietnam and indonesia. as a pr ... | 2018 | 30479676 |
| validation of sysmex xt-2000iv analyzer-generated quantitative bone marrow differential counts in cynomolgus monkeys, beagle dogs, and cd-1 mice. | in a previous study, the validation of rat bone marrow (bm) collection, processing, and analysis using the sysmex xt-2000iv (sysmex corporation, kobe, japan) hematology analyzer showed that the sysmex hematology analyzer produced bm differential counts that were comparable to those obtained with microscopic differential counts. | 2018 | 30476353 |
| virulence of marburg virus angola compared to mt. elgon (musoke) in macaques: a pooled survival analysis. | angola variant (marv/ang) has replaced mt. elgon variant musoke isolate (marv/mte-mus) as the consensus standard variant for marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the higher virulence of marv/ang. in this retrospective study, we used data pooled from eight separate studies in nonhuman primates experimentally exposed with either 1000 pfu intramuscular (im) marv/ang or m ... | 2018 | 30469360 |
| nonclinical safety assessment of a human interleukin-22fc ig fusion protein demonstrates in vitro to in vivo and cross-species translatability. | although interleukin-22 (il-22) is produced by various leukocytes, it preferentially targets cells with epithelial origins. il-22 exerts essential roles in modulating various tissue epithelial functions, such as innate host defense against extracellular pathogens, barrier integrity, regeneration, and wound healing. therefore, il-22 is thought to have therapeutic potential in treating diseases associated with infection, tissue injury or chronic tissue damage. a number of in vitro and in vivo nonc ... | 2018 | 30464842 |
| withdrawn: indel-informed bayesian analysis suggests cryptic divisions between plasmodium knowlesi of humans and long-tailed macaques (macaca fascicularis) in malaysian borneo. | this article has been withdrawn at the request of the author(s) and/or editor. the publisher apologizes for any inconvenience this may cause. the full elsevier policy on article withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. | 2018 | 30481580 |
| intramuscular exposure of macaca fascicularis to low doses of low passage- or cell culture-adapted sudan virus or ebola virus. | the filoviruses ebola virus (ebov) and sudan virus (sudv) can cause severe diseases, and there are currently no licensed countermeasures available for use against them. transmission occurs frequently via contact with bodily fluids from infected individuals. however, it can be difficult to determine when or how someone became infected, or the quantity of infectious virus to which they were exposed. evidence suggests the infectious dose is low, but the majority of published studies use high exposu ... | 2018 | 30453499 |
| preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents. | several tyrosine kinase inhibitors (tkis) developed as anti-cancer drugs, also have anti-viral activity due to their ability to disrupt productive replication and dissemination in infected cells. consequently, such drugs are attractive candidates for "repurposing" as anti-viral agents. however, clinical evaluation of therapeutics against infectious agents associated with high mortality, but low or infrequent incidence, is often unfeasible. the united states food and drug administration formulate ... | 2018 | 30514402 |
| diversity of ulbp5 in old-world monkeys (cercopithecidae) and divergence of the ulbp gene family in primates. | non-human primates such as rhesus macaque and cynomolgus macaque are important animals for medical research. these species are classified as old-world monkeys (cercopithecidae), in which the immune-related genome structure is characterized by gene duplications. in the present study, we investigated polymorphisms in two genes for ulbp5 encoding ligands for nkg2d. we found 18 and 11 ulbp5.1 alleles and 11 and 13 ulbp5.2 alleles in rhesus macaques and cynomolgus macaques, respectively. in addition, ... | 2018 | 30541969 |
| engineering of a glp-1 analogue peptide/anti-pcsk9 antibody fusion for type 2 diabetes treatment. | type 2 diabetes (t2d) is a complex and progressive disease requiring polypharmacy to manage hyperglycaemia and cardiovascular risk factors. however, most patients do not achieve combined treatment goals. to address this therapeutic gap, we have developed medi4166, a novel glucagon-like peptide-1 (glp-1) receptor agonist peptide fused to a proprotein convertase subtilisin/kexin type 9 (pcsk9) neutralising antibody that allows for glycaemic control and low-density lipoprotein cholesterol (ldl-c) l ... | 2018 | 30510163 |
| improving cell survival in injected embryos allows primed pluripotent stem cells to generate chimeric cynomolgus monkeys. | monkeys are an optimal model species for developing stem cell therapies. we previously reported generating chimeric cynomolgus monkey fetuses using dome-shaped embryonic stem cells (descs). however, conventional primed pluripotent stem cells (ppscs) lack chimera competency. here, by altering the media in which injected morulae are cultured, we observed increased survival of cynomolgus monkey primed escs, induced pscs, and somatic cell nuclear transfer-derived escs, thereby enabling chimeric cont ... | 2018 | 30485820 |
| syntheses and in vitro biological evaluation of s1pr1 ligands and pet studies of four f-18 labeled radiotracers in the brain of nonhuman primates. | a series of seventeen hydroxyl-containing sphingosine 1-phosphate receptor 1 (s1pr1) ligands were designed and synthesized. their in vitro binding potencies were determined using [32p]s1p competitive binding assays. compounds 10a, 17a, 17b, and 24 exhibited high s1pr1 binding potencies with ic50 values ranging from 3.9 to 15.4 nm and also displayed high selectivity for s1pr1 over other s1p receptor subtypes (ic50 > 1000 nm for s1pr2-5). the most potent compounds 10a, 17a, 17b, and 24 were subseq ... | 2018 | 30462126 |
| zikv demonstrates minimal pathologic effects and mosquito infectivity in viremic cynomolgus macaques. | to evaluate the effects of zikv infection on non-human primates (nhps), as well as to investigate whether these nhps develop sufficient viremia to infect the major urban vector mosquito, aedes aegypti, four cynomolgus macaques (macaca fascicularis) were subcutaneously infected with 5.0 log10 focus-forming units (ffu) of dna clone-derived zikv strain fss13025 (asian lineage, cambodia, 2010). following infection, the animals were sampled (blood, urine, tears, and saliva), underwent daily health mo ... | 2018 | 30469417 |
| characterization of a candidate tetravalent vaccine based on 2'-o-methyltransferase mutants. | dengue virus (denv) is one of the most widespread arboviruses. the four denv serotypes infect about 400 million people every year, causing 96 million clinical dengue cases, of which approximately 500'000 are severe and potentially life-threatening. the only licensed vaccine has a limited efficacy and is only recommended in regions with high endemicity. we previously reported that 2'-o-methyltransferase mutations in denv-1 and denv-2 block their capacity to inhibit type i ifns and render the viru ... | 2018 | 29298302 |
| immunogenicity of recombinant measles vaccine expressing fusion protein of respiratory syncytial virus in cynomolgus monkeys. | respiratory syncytial virus (rsv) is a common cause of respiratory infections in infants. effective vaccines are currently being sought, but no vaccine is thus far available. in our previous study, recombinant aik-c measles vaccine expressing the rsv fusion protein (mvaik/rsv/f) was developed and protective immunity against rsv demonstrated in cotton rats. in the present study, the immunogenicity and protective effects were investigated in three cynomolgus monkeys immunized with mvaik/rsv/f. neu ... | 2018 | 29194753 |
| treatment of paraquat-induced lung injury with an anti-c5a antibody: potential clinical application. | complement activation product c5a plays a critical role in systemic inflammatory response syndrome induced by viruses, bacteria, and toxic agents including paraquat poisoning. this study is to explore the efficiency of anti-c5a-based intervention on systemic inflammatory responses induced by paraquat poisoning. | 2018 | 29293144 |
| blood rna signatures prospectively discriminate controllers from progressors early after low-dose m. tuberculosis infection of cynomolgus macaques. | the cynomolgus macaque model of low-dose mycobacterium tuberculosis (mtb) infection recapitulates clinical aspects of human tb pathology but it is unknown whether the two systems are sufficiently similar that host-based signatures of tb will be predictive across species. by blind prediction, we demonstrate that a subset of genes comprising a human signature for tb risk is simultaneously predictive in humans and macaques and prospectively discriminates progressor from controller animals 3-6 weeks ... | 2018 | 29325117 |
| prime and boost vaccination elicit a distinct innate myeloid cell immune response. | understanding the innate immune response to vaccination is critical in vaccine design. here, we studied blood innate myeloid cells after first and second immunization of cynomolgus macaques with the modified vaccinia virus ankara. the inflammation at the injection site was moderate and resolved faster after the boost. the blood concentration of inflammation markers increased after both injections but was lower after the boost. the numbers of neutrophils, monocytes, and dendritic cells were trans ... | 2018 | 29449630 |
| experimental autoimmune encephalomyelitis (eae) model of cynomolgus macaques induced by recombinant human mog1-125 (rhmog1-125) protein and mog34-56 peptide. | experimental autoimmune encephalomyelitis (eae) induced by self-myelin antigen is a widely used in multiple sclerosis (ms) model for preclinical studies of new therapeutics and potential pathogenesis. by comparison with rodent eae models, eae models in primates are more similar to ms. some groups have developed eae models in primates by using common marmoset (callithrix jacchus). however, this model has some limitations. eae in cynomolgus monkey (macaque fasciculrais) could overcome these limita ... | 2018 | 29141529 |
| association with polymorphic marmoset cytochrome p450 2c19 of in vivo hepatic clearances of chirally separated r-omeprazole and s-warfarin using individual marmoset physiologically based pharmacokinetic models. | 1. simulated clearances of r-warfarin and efavirenz were recently reported for individual cynomolgus monkeys genotyped for cytochrome p450 2c19 and 2c9, respectively. to expand and verify this modeling procedure, simulations of r/s-omeprazole and r/s-warfarin clearances after oral administrations in individual marmosets were performed using individual simplified physiologically based pharmacokinetic (pbpk) modeling consisting of gut, liver and central compartments. 2. pharmacokinetics of r/s-ome ... | 2018 | 29034770 |
| the japan monkey centre primates brain imaging repository for comparative neuroscience: an archive of digital records including records for endangered species. | advances in magnetic resonance imaging (mri) and computational analysis technology have enabled comparisons among various primate brains in a three-dimensional electronic format. results from comparative studies provide information about common features across primates and species-specific features of neuroanatomy. investigation of various species of non-human primates is important for understanding such features, but the majority of comparative mri studies have been based on experimental primat ... | 2018 | 30357587 |
| a recombinant subunit based zika virus vaccine is efficacious in non-human primates. | zika virus (zikv), a virus with no severe clinical symptoms or sequelae previously associated with human infection, became a public health threat following an epidemic in french polynesia 2013-2014 that resulted in neurological complications associated with infection. although no treatment currently exists, several vaccines using different platforms are in clinical development. these include nucleic acid vaccines based on the prm-e protein from the virus and purified formalin-inactivated zikv va ... | 2018 | 30467501 |
| validation of a noninvasive hair trapping method for extractive-foraging primates. | hair is a useful source of biological information. for example, the bulb can be a source of high-quality genetic material, whereas the shaft can be useful for measuring heavy metals and some hormones, such as cortisol. the stable isotope composition of hair is another valuable source of biological information. consequently, noninvasive methods of hair sampling have become important research tools. several hair-trapping methods have been developed for use on mammals, but these are rarely deployed ... | 2018 | 30404083 |