Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| epigenetic modulation associated with carcinogenesis and prognosis of human gastric cancer. | gastric cancer (gc) is a leading cause of cancer-related death, particularly in asia. epidemiological and other clinical studies have identified an association between a number of risk factors, including helicobacter pylori, and gc. a number of studies have also examined genetic changes associated with the development and progression of gc. when considering the clinical significance of the expression of a specific gene, its epigenetic modulation should be considered. epigenetic modulation appear ... | 2017 | 28529571 |
| [frequency of helicobacter pylori nitroreductase rdxa mutations for metronidazole activation in a population in the cauca department, colombia]. | resistance to metronidazole is a key factor associated with helicobacter pylori treatment failure. even though resistance is mostly associated with rdxa nitroreductase mutations, studies of this h. pylori protein in popayán (colombia) are still incipient. | 2017 | 28527283 |
| development of genipin-crosslinked fucoidan/chitosan-n-arginine nanogels for preventing helicobacter infection. | this study aims to validate the anti-helicobacter pylori efficacy of amoxicillin-loaded nanoparticles and nanogels with ph-responsive and site-specific drug release properties against h. pylori infection. | 2017 | 28524785 |
| randomized controlled study of a novel triple nitazoxanide (ntz)-containing therapeutic regimen versus the traditional regimen for eradication of helicobacter pylori infection. | helicobacter pylori infection has become more and more resistant to conventional first-line treatment regimens. so, there is a considerable interest in evaluating new antibiotic combinations and regimens. nitazoxanide is an anti-infective drug with demonstrated activity against protozoa and anaerobic bacteria including h. pylori. this work is designed to evaluate the efficacy and safety of a unique triple nitazoxanide-containing regimen as a treatment regimen in egyptian patients with h. pylori ... | 2017 | 28524341 |
| ubiquitin specific peptidase 5 mediates histidine-rich protein hpn induced cell apoptosis in hepatocellular carcinoma through p14-p53 signaling. | hpn is a small histidine-rich cytoplasmic protein from helicobacter pylori and has been recognized as a high-risk factor for several cancers including gastric cancer, colorectal cancer, and malt lymphoma. however, the relationship between hpn and cancers remains elusive. in this study, we discovered that hpn protein effectively suppressed cell growth and induced apoptosis in hepatocellular carcinoma (hcc). a two-dimensional gel electrophoresis and mass spectrometry-based comparative proteomics w ... | 2017 | 28523650 |
| detection and genotyping of helicobacter pylori among gastric ulcer and cancer patients from saudi arabia. | helicobacter pylori (h. pylori) infection is cause of several gastrointestinal diseases in humans. virulence genes of h. pylori are associated with severity of disease and vary geographically. the aim of present study was to detect h. pylori in formalin-fixed paraffin-embedded (ffpe) tissues and further investigate prevalence of baba2, caga, icea1, icea2, vaca s1/s2 and vaca m1/m2 genotypes in h. pylori from gastric cancer (gc) and gastric ulcer (gu) patients' biopsy samples. | 2017 | 28523030 |
| strategies used by helicobacter pylori to establish persistent infection. | helicobacter pylori (h. pylori) is a gram-negative and motile bacterium that colonizes the hostile microniche of the human stomach, then persists for the host's entire life, if not effectively treated. clinically, h. pylori plays a causative role in the development of a wide spectrum of diseases including chronic active gastritis, peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. due to the global distribution of h. pylori, it is no exaggeration t ... | 2017 | 28522905 |
| importance of antimicrobial susceptibility testing for the management of eradication in helicobacter pylori infection. | the management of helicobacter pylori (h. pylori) infection treatment differs from the common treatment protocol for other infectious diseases. because culture- or molecular-guided approaches face several practical issues, such as the invasive procedures required to obtain gastric biopsy specimens and the lack of availability of routine laboratory testing in some places, h. pylori treatment includes the administration of two or three empirically selected antibiotics combined with a proton pump i ... | 2017 | 28522904 |
| cut-off optimization for (13)c-urea breath test in a community-based trial by mathematic, histology and serology approach. | the performance of diagnostic tests in intervention trials of helicobacter pylori (h.pylori) eradication is crucial, since even minor inaccuracies can have major impact. to determine the cut-off point for (13)c-urea breath test ((13)c-ubt) and to assess if it can be further optimized by serologic testing, mathematic modeling, histopathology and serologic validation were applied. a finite mixture model (fmm) was developed in 21,857 subjects, and an independent validation by modified giemsa staini ... | 2017 | 28522798 |
| natural course of helicobacter pylori infection in japanese hemodialysis patients. | helicobacter pylori (h. pylori) infection is one of the major risk factors for gastrointestinal morbidity in hemodialysis patients. primary end point is to investigate h. pylori infection rate in hemodialysis patients. as secondary end point, we clarified whether pepsinogen (pg) level was related with h. pylori infection status in hemodialysis patients. | 2017 | 28521319 |
| gastric perforation caused by an intragastric balloon: endoscopic findings. | intragastric balloon (igb) insertion has been most frequently used in the west as an effective endoscopic treatment for morbid obesity, in practice. recently, there is a growing number of cases requiring igb deployment for obesity treatment in korea. one of the reported complications of igb use is gastric perforation. a 47-year-old woman was admitted to the hospital with mild symptoms, 7 weeks after having an igb placed. esophagogastroduodenoscopy was performed and gastric ulcer perforation was ... | 2017 | 28516757 |
| role of lps-elicited signaling in triggering gastric mucosal inflammatory responses to h. pylori: modulatory effect of ghrelin. | infection with helicobacter pylori is a primary culprit in the etiology of gastric disease, and its cell-wall lipopolysaccharide (lps) is recognized as a potent endotoxin responsible for triggering a pattern of the mucosal inflammatory responses. the engagement by the lps of gastric mucosal toll-like receptor 4 (tlr4) leads to initiation of signal transduction events characterized by the activation of mitogen-activated protein kinase (mapk) cascade, induction of phosphoinositide-specific phospho ... | 2017 | 28516374 |
| comparison of amoxicillin and metronidazole effect on three-drug regimen for the treatment of helicobacter pylori infection in children. | helicobacter pylori is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. three-drug regimen is the first-line treatment for this infection, but the response rate to treatment varies in different geographical regions. this study was conducted to comparatively determine the effect of amoxicillin and metronidazole on three-drug regimen to treat h. pylori infection in 1-15-year-old children. this clinical trial was conducted on 82 patients aged 1-15 years with conveni ... | 2017 | 28516058 |
| a novel stool pcr test for helicobacter pylori may predict clarithromycin resistance and eradication of infection at a high rate. | clarithromycin-based regimens are commonly used as a first-line therapy for helicobacter pylori-positive patients; however, resistance to clarithromycin has led to treatment failures. the aim of this study was to evaluate the feasibility of using stool samples to detect the presence of h. pylori dna while concurrently detecting mutations associated with resistance to clarithromycin. for this purpose, total dna was extracted from 294 raw stool specimens from h. pylori-positive and -negative patie ... | 2017 | 28515219 |
| [new opportunities for the prevention of gastric cancer]. | the approvals and provisions of the management of helicobacter pylori infection-the maastricht v/ florence consensus report and those of the kyoto global consensus conference on h. pylori-associated gastritis, concerning with the primary and secondary prevention of gastric cancer (gc), unambiguously suggest that h. pylori infection is the most important risk factor of gc. accordingly, the basis for the primary and secondary prevention of gc is the optimization of h. pylori eradication therapy. t ... | 2017 | 28514409 |
| how to stomach an epigenetic insult: the gastric cancer epigenome. | gastric cancer is a deadly malignancy afflicting close to a million people worldwide. patient survival is poor and largely due to late diagnosis and suboptimal therapies. disease heterogeneity is a substantial obstacle, underscoring the need for precision treatment strategies. studies have identified different subgroups of gastric cancer displaying not just genetic, but also distinct epigenetic hallmarks. accumulating evidence suggests that epigenetic abnormalities in gastric cancer are not mere ... | 2017 | 28513632 |
| the efficacy of sequential therapy in eradication of helicobacter pylori in turkey. | most of the studies about sequential therapy that have been reported from turkey were levofloxacin based. we aimed to compare the helicobacter pylori (h. pylori) eradication rates of standard triple, sequential and quadruple therapies including claritromycin regimes in this study. | 2017 | 28513523 |
| application of proteomics to the study of helicobacter pylori and implications for the clinic. | helicobacter pylori (h. pylori) is a gram-negative bacterium that colonizes the gastric epithelium and mucous layer of more than half the world's population. h. pylori is a primary human pathogen, responsible for the development of chronic gastritis, peptic ulceration and gastric cancer. proteomics is impacting several aspects of medical research: understanding the molecular basis of infection and disease manifestation, identification of therapeutic targets and discovery of clinically relevant b ... | 2017 | 28513226 |
| genetic alterations in gastric cancer associated with helicobacter pylori infection. | gastric cancer is a world health problem and depicts the fourth leading mortality cause from malignancy in mexico. causation of gastric cancer is not only due to the combined effects of environmental factors and genetic variants. recent molecular studies have transgressed a number of genes involved in gastric carcinogenesis. the aim of this review is to understand the recent basics of gene expression in the development of the process of gastric carcinogenesis. genetic variants, polymorphisms, de ... | 2017 | 28512631 |
| infections and follicular lymphoma: is there a link? | several infectious agents appear to provide a proliferative signal -- "antigen-drive" - that could be implicated in the pathogenesis of various type of non-hodgkin lymphoma (nhl). a classical model of the infection-driven lymphoproliferative disorder is helicobacter pylori-induced gastric malt lymphoma, where antibiotic therapy allows the eradication of both the infectious agent and the clonal b-cell expansion. following the footsteps of this example, several retrospective studies have found a c ... | 2017 | 28512564 |
| subversion of host kinases: a key network in cellular signaling hijacked by helicobacter pylori caga. | helicobacter pylori is a paradigm of persistent pathogens and major risk factor for developing severe diseases including adenocarcinoma in the human stomach. an important bacterial factor linked to gastric disease progression is the cag pathogenicity island-encoded type-iv secretion system (t4ss) effector protein caga. translocated caga undergoes tyrosine phosphorylation at epiya-motifs and then activates or inactivates multiple host signaling proteins in a phosphorylation-dependent and phosphor ... | 2017 | 28508421 |
| does helicobacter pylori infection increase the risk of adult-onset asthma? | 2017 | 28508347 | |
| the sleeping remnant. effect of roux-en-y gastric bypass on plasma levels of gastric biomarkers in morbidly obese women: a prospective longitudinal study. | morpho-functional modifications of the gastric remnant after roux-en-y gastric bypass (rygb) have not been completely defined, due to its inaccessibility for bioptic mapping. the aim of the study is to evaluate such modifications using gastropanel®, a non-invasive blood test cross-checking four gastric biomarkers, able to provide a snapshot of mucosa conditions. | 2017 | 28508274 |
| endoscopic view of gastroduodenal artery coils at the base of duodenal ulcer in case of recurrent massive upper gastrointestinal bleed. | helicobacter pylori (h. pylori) infection is one of the major causes of bleeding peptic ulcer disease, which is associated with serious complications; therefore, the eradication of h. pylori is essential to prevent these devastating complications. post-treatment follow-up is crucial to guarantee the eradication of the organism and may be conducted via the urea breath test, the stool antigen test, or a gastric biopsy. acute massive upper gastrointestinal (ugi) bleeding is one of the most common c ... | 2017 | 28507835 |
| serum vegf levels in helicobacter pylori infection and correlation with helicobacter pylori caga and vaca genes. | helicobacter pylori vaca and caga genes are associated with higher virulence. vascular endothelial growth factor (vegf) is one important marker for neo-angiogenesis. | 2017 | 28507617 |
| primary helicobacter pylori resistance in elderly patients over 20 years: a bulgarian study. | we evaluated the antibiotic susceptibility of 233 helicobacter pylori strains isolated in the period 2011-2016, involving 62 strains from elderly patients aged 66-93years and 171 strains from younger adults. to assess resistance evolution, primary resistance rates in 92 strains from as many patients aged ≥60years in 1996-2003 were compared with those in 85 strains from infected patients in the same age group in 2011-2016. in the patients aged >65years evaluated during the last 6 years, amoxicill ... | 2017 | 28506722 |
| [antimicrobial susceptibility of helicobacter pylori strains isolated from gastric lesions]. | antimicrobial susceptibility was evaluated by two diffusion methods: e-test strips to determine minimum inhibitory concentration (mic) and disk diffusion for amoxicillin, clarithromycin, metronidazole and ciprofloxacin in 30 helicobacter pylori strains isolated from gastric biopsies. no strains were resistant to amoxicillin, 17% (5/30) were resistant to clarithromycin, 20% (6/30) ciprofloxacin by both methods, and 37% (11/30) to metronidazole by the e-test. although the number of strains studied ... | 2017 | 28506634 |
| determining the igm and igg antibody titer against cmv and helicobacter pylori in the serum of multiple sclerosis patients comparing to the control group in hamadan. | multiple sclerosis (ms) is a chronic autoimmune disease that disables central nervous system (cns) system. cytomegalovirus (cmv) probably has an important role in the ms pathology. the infection with helicobacter pylori also is recognized as a protective agent against ms in female. | 2017 | 28505965 |
| anti-helicobacter pylori activity of non-living, heat-killed form of lactobacilli including lactobacillus johnsonii no.1088. | some strains of lactic acid bacteria are reported to inhibit the growth of helicobacter pylori and proposed to be useful to support so-called triple therapy for h. pylori. although most strains must be alive to exert their anti-h. pylori activity, some lactobacilli strains are effective even when dead. one possible underlying mechanism of such an activity of non-living lactobacilli is reportedly co-aggregation with h. pylori. in this study, we found that a non-living heat-killed form of lactobac ... | 2017 | 28505287 |
| exopolysaccharide-producing streptococcus thermophilus crl1190 reduces the inflammatory response caused by helicobacter pylori. | this work evaluated the ability of the probiotic streptococcus thermophilus crl1190 strain and its exopolysaccharides to adhere to gastric mucosa. probiotic bacteria attachment to the human stomach epithelium was confirmed in human stomach tissue samples and the gastric epithelial cell line ags. in addition, it was demonstrated that s. thermophilus crl1190 strain reduced helicobacter pylori adhesion and attenuated inflammatory response in ags cells. this is the first demonstration of the capacit ... | 2017 | 28504579 |
| mental vulnerability, helicobacter pylori, and incidence of hospital-diagnosed peptic ulcer over 28 years in a population-based cohort. | to examine whether mental vulnerability, an enduring personality characteristic, predicts incident hospital-diagnosed ulcer over three decades. | 2017 | 28503971 |
| helicobacter is preserved in yeast vacuoles! does koch's postulates confirm it? | the manuscript titled "vacuoles of candida yeast behave as a specialized niche for helicobacter pylori (h. pylori)" not only has not been prepared in a scientific manner but the methodology used was not adequate, and therefore the conclusion reached was not correct. first of all, "yeast" is a broad terminology covering a great number of genera and species of unicellular micro-organisms. the authors should have defined the organism with its binary scientific name. this measure would allow experim ... | 2017 | 28405156 |
| cytotoxic and antimicrobial activities of cantharellus cibarius fr. (cantarellaceae). | antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of cantharellus cibarius were tested. broth microdilution assay was performed against 10 bacterial strains (staphylococcus aureus, s. epidermidis, micrococcus luteus, bacillus subtilis, enterococcus feacalis, escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, salmonella abony), with emphasis on helicobacter pylori. methanol extract was the most active against h. pylori strains wit ... | 2017 | 28613963 |
| the recombinant fusion protein of cholera toxin b and neutrophil-activating protein expressed on bacillus subtilis spore surface suppresses allergic inflammation in mice. | the neutrophil-activating protein of helicobacter pylori (hp-nap) has been identified as a modulator with anti-th2 inflammation activity, and cholera toxin b (ctb) is a mucosal adjuvant that can also induce antigen tolerance. in this study, we constructed a ctb-nap fusion protein on the surface of bacillus subtilis spore and evaluate the efficiency of oral administration of the recombinant ctb-nap spores in preventing asthma in mice. oral administration of recombinant ctb or ctb-nap spores signi ... | 2017 | 28608279 |
| the helicobacter pylori type iv secretion system promotes il-8 synthesis in a model of pediatric airway epithelium via p38 map kinase. | epidemiologic studies have reported an inverse relationship between childhood helicobacter pylori infection and development of allergic asthma. because lung epithelium plays an important role in allergic asthma pathogenesis, we hypothesized that h. pylori may directly influence airway epithelial cell innate immune function, particularly in early childhood. to test our hypothesis, we established an in vitro h. pylori infection model using primary tracheobronchial epithelial cell cultures derived ... | 2017 | 28813514 |
| dynamic expression of the baba adhesin and its babb paralog during helicobacter pylori infection in rhesus macaques. | most helicobacter pylori strains express the baba adhesin, which binds to abo/leb blood group antigens on gastric mucin and epithelial cells and is found more commonly in strains that cause peptic ulcers or gastric cancer, rather than asymptomatic infection. we and others have previously reported that in mice, gerbils, and rhesus macaques, expression of baba is lost, either by phase variation or by gene conversion, in which the babb paralog recombines into the baba locus. the functional signific ... | 2017 | 28396320 |
| site-specific his/asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance. | phosphorylation of amino acid residues on proteins is an important and common post-translational modification in both eukaryotes and prokaryotes. most research work has been focused on phosphorylation of serine, threonine or tyrosine residues, whereas phosphorylation of other amino acids are significantly less clear due to the controversy on their stability under standard bioanalytical conditions. | 2017 | 28545444 |
| functional interaction and structural characteristics of unique components of helicobacter pylori t4ss. | the helicobacter pylori infection of the human gastric mucosa causes chronic active gastritis and peptic ulcers and is associated with the development of gastric cancer. epidemiological studies show that these gastric diseases are related to virulent h. pylori strains that harbor the cytotoxin-associated gene pathogenicity island (cag pai). the cag pai is a dna insertion in the h. pylori chromosome that encodes ~ 27 proteins, including the oncoprotein caga. approximately 20 of these proteins hav ... | 2017 | 28470874 |
| efficacy and safety of probiotic-supplemented triple therapy for eradication of helicobacter pylori in children: a systematic review and network meta-analysis. | the aim of this study was to identify the best probiotic supplementation in triple therapy for pediatric population with helicobacter pylori infection. | 2017 | 28681177 |
| restriction glycosylases: involvement of endonuclease activities in the restriction process. | all restriction enzymes examined are phosphodiesterases generating 3΄-oh and 5΄-p ends, but one restriction enzyme (restriction glycosylase) excises unmethylated bases from its recognition sequence. whether its restriction activity involves endonucleolytic cleavage remains unclear. one report on this enzyme, r.pabi from a hyperthermophile, ascribed the breakage to high temperature while another showed its weak ap lyase activity generates atypical ends. here, we addressed this issue in mesophiles ... | 2017 | 28180312 |
| pathogen-induced ubiquitin-editing enzyme a20 bifunctionally shuts off nf-κb and caspase-8-dependent apoptotic cell death. | the human pathogen helicobacter pylori infects more than half of the world's population and is a paradigm for persistent yet asymptomatic infection but increases the risk for chronic gastritis and gastric adenocarcinoma. for successful colonization, h. pylori needs to subvert the host cell death response, which serves to confine pathogen infection by killing infected cells and preventing malignant transformation. infection of gastric epithelial cells by h. pylori provokes direct and fast activat ... | 2017 | 28574503 |
| immunoprevalence to six waterborne pathogens in beachgoers at boquerón beach, puerto rico: application of a microsphere-based salivary antibody multiplex immunoassay. | waterborne infectious diseases are a major public health concern worldwide. few methods have been established that are capable of measuring human exposure to multiple waterborne pathogens simultaneously using non-invasive samples such as saliva. most current methods measure exposure to only one pathogen at a time, require large volumes of individual samples collected using invasive procedures, and are very labor intensive. in this article, we applied a multiplex bead-based immunoassay capable of ... | 2017 | 28507984 |
| organoid culture systems to study host-pathogen interactions. | recent advances in host-microbe interaction studies in organoid cultures have shown great promise and have laid the foundation for much more refined future studies using these systems. modeling of zika virus (zikv) infection in cerebral organoids have helped us understand its association with microcephaly. similarly, the pathogenesis of bacterial (helicobacter pylori, clostridium difficile) and viral (norovirus, rotaviruses) infections have been precisely dissected in organoid cultures. addition ... | 2017 | 28756233 |
| a review of the novel application and potential adverse effects of proton pump inhibitors. | proton pump inhibitors (ppis) are known as a class of pharmaceutical agents that target h(+)/k(+)-atpase, which is located in gastric parietal cells. ppis are widely used in the treatment of gastric acid-related diseases including peptic ulcer disease, erosive esophagitis and gastroesophageal reflux disease, and so on. these drugs present an excellent safety profile and have become one of the most commonly prescribed drugs in primary and specialty care. except for gastric acid-related diseases, ... | 2017 | 28429247 |
| mucosal microbiome dysbiosis in gastric carcinogenesis. | we aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis. | 2017 | 28765474 |
| mechanism of transformation in mycobacteria using a novel shockwave assisted technique driven by in-situ generated oxyhydrogen. | we present a novel method for shockwave-assisted bacterial transformation using a miniature oxyhydrogen detonation-driven shock tube. we have obtained transformation efficiencies of about 1.28 × 10(6), 1.7 × 10(6), 5 × 10(6), 1 × 10(5), 1 × 10(5) and 2 × 10(5) transformants/µg of dna for escherichia coli, salmonella typhimurum, pseudomonas aeruginosa, mycobacterium smegmatis, mycobacterium tuberculosis (mtb) and helicobacter pylori respectively using this method which are significantly higher th ... | 2017 | 28819202 |
| enzymatic synthesis of n-acetyllactosamine (lacnac) type 1 oligomers and characterization as multivalent galectin ligands. | repeats of the disaccharide unit n-acetyllactosamine (lacnac) occur as type 1 (galβ1, 3glcnac) and type 2 (galβ1, 4glcnac) glycosylation motifs on glycoproteins and glycolipids. the lacnac motif acts as binding ligand for lectins and is involved in many biological recognition events. to the best of our knowledge, we present, for the first time, the synthesis of lacnac type 1 oligomers using recombinant β1,3-galactosyltransferase from escherichia coli and β1,3-n-acetylglucosaminyltranferase from ... | 2017 | 28796164 |
| aminophosphinates against helicobacter pylori ureolysis-biochemical and whole-cell inhibition characteristics. | urease is an important virulence factor from helicobacter pylori that enables bacterial colonization of human gastric mucosa. specific inhibition of urease activity can be regarded as a promising adjuvant strategy for eradication of this pathogen. a group of organophosphorus inhibitors of urease, namely, aminophosphinic acid and aminophosphonic acid derivatives, were evaluated in vitro against h. pylori urease. the kinetic characteristics of recombinant enzyme activity demonstrated a competitive ... | 2017 | 28792967 |
| novel protein interactions with an actin homolog (mreb) of helicobacter pylori determined by bacterial two-hybrid system. | the bacterium helicobacter pylori infects more than 50% of the world population and causes several gastroduodenal diseases, including gastric cancer. nevertheless, we still need to explore some protein interactions that may be involved in pathogenesis. mreb, an actin homolog, showed some special characteristics in previous studies, indicating that it could have different functions. protein functions could be realized via protein-protein interactions. in the present study, the mreb protein from h ... | 2017 | 28602400 |
| histo-blood group antigens as mediators of infections. | the critical first step of a microbial infection is usually the attachment of pathogens to host cell glycans. targets on host tissues are in particular the histo-blood group antigens (hbgas), which are present in rich diversity in the mucus layer and on the underlying mucosa. recent structural and functional studies have revealed significant new insight into the molecular mechanisms, explaining why individuals with certain blood groups are at increased risk of some infections. the most prominent ... | 2017 | 28544984 |
| fusion expression of the pgla-am1 with native structure and evaluation of its anti-helicobacter pylori activity. | helicobacter pylori (h. pylori) shows increasingly enhanced resistance to various antibiotics, and its eradication has become a major problem in medicine. the antimicrobial peptide pgla-am1 is a short peptide with 22 amino acids and exhibits strong antibacterial activity. in this study, we investigated whether it has anti-h. pylori activity for the further development of anti-h. pylori drugs to replace existing antibiotics. however, the natural antimicrobial peptide pgla-am1 shows a low yield an ... | 2017 | 28488117 |
| characterization of non-dialyzable constituents from cranberry juice that inhibit adhesion, co-aggregation and biofilm formation by oral bacteria. | an extract prepared from cranberry juice by dialysis known as nondialyzable material (ndm) has been shown previously to possess anti-adhesion activity toward microbial species including oral bacteria, uropathogenic escherichia coli and helicobacter pylori. bioassay-guided fractionation of cranberry ndm was therefore undertaken to identify the anti-adhesive constituents. an aqueous acetone-soluble fraction (ndmac) obtained from sephadex lh-20 inhibited adhesion-linked activities by oral bacteria, ... | 2017 | 28470309 |
| unveiling differentially expressed genes upon regulation of transcription factors in sepsis. | in this study, we integrated the gene expression data of sepsis to reveal more precise genome-wide expression signature to shed light on the pathological mechanism of sepsis. differentially expressed genes via integrating five microarray datasets from the gene expression omnibus database were obtained. the gene function and involved pathways of differentially expressed genes (degs) were detected by genecodis3. transcription factors (tfs) targeting top 20 dysregulated degs (including up- and down ... | 2017 | 28444588 |
| efficient production of nanobodies against urease activity ofhelicobacter pylori in pichia pastoris. | helicobacter pylori is a major health problem. one of the therapeutic approaches is administration of antibody against h. pylori. the methylotrophic pichia pastoris is a suitable host for expression of recombinant antibody fragments. the aims of this study were the expression and the evaluation of camelid nanobody in the yeast pichia pastoris. | 2017 | 28425268 |
| epidemiological study of gastric helicobacter spp. in dogs with gastrointestinal disease in japan and diversity of helicobacter heilmannii sensu stricto. | epidemiological and pathological studies of helicobacter spp. in canine stomachs in japan were performed to investigate strain specific pathogenicity. gastric biopsies from 144 dogs with gastrointestinal diseases were evaluated for the presence of helicobacter spp. using genus and species specific pcrs for helicobacter felis, helicobacter bizzozeronii, helicobacter heilmannii sensu stricto (s.s.) and helicobacter pylori. pcr indicated that 50/144 (34.7%) dogs were infected with helicobacter spp. ... | 2017 | 28720300 |
| a new animal model of gastric lymphomagenesis: april transgenic mice infected by helicobacter species. | april is a member of the tumor necrosis factor cytokine family involved in the regulation of b-cell immunity. we present a study of the infection by helicobacter species of transgenic (tg) c57bl6 mice, ectopically expressing the human form of april. wild-type (wt) and april tg mice were infected with helicobacter felis and helicobacter pylori and compared with noninfected animals. mice were euthanized 18 months after infection, and inflammatory responses and histologic alterations were analyzed. ... | 2017 | 28460208 |
| cloning of helicobacter suis cholesterol α-glucosyltransferase and production of an antibody capable of detecting it in formalin-fixed, paraffin-embedded gastric tissue sections. | helicobacter suis (h. suis), formerly called helicobacter heilmannii type 1 (h. heilmannii), is a gram-negative bacterium of the helicobacter species. this pathogen infects the stomach of humans and animals such as dogs, cats, pigs, and rodents, the latter giving rise to zoonotic infection. here, we generated a h. suis-specific antibody useful for immunohistochemistry with formalin-fixed, paraffin-embedded tissue sections. to do so, we began by cloning the gene encoding h. suis cholesterol α-glu ... | 2017 | 28534071 |
| outcomes of patients hospitalized with peptic ulcer disease diagnosed in acute upper endoscopy. | the incidence and complications of peptic ulcer disease (pud) have declined, but mortality from bleeding ulcers has remained unchanged. the aims of the current study were to evaluate the significance of pud among patients admitted for acute upper endoscopy and to evaluate the survival of pud patients. | 2017 | 28857894 |
| future directions in improving outcomes for patients with gastric and esophageal cancer. | "this issue of hematology/oncology clinics of north america provides an update to the current understanding of the physiology of gastric and esophageal cancers and the state-of-the-art management of disease. over the past 10 years, we have witnessed dramatic changes in both our understanding of the disease and its management. we have 2 new biological agents approved to treat advanced disease, with several more prospects under development. in this article, the author looks to the future, attempti ... | 2017 | 28501093 |
| the gastric microbiome and its influence on gastric carcinogenesis: current knowledge and ongoing research. | gastric malignancies are a leading cause of cancer-related death worldwide. at least 2 microbial species are currently linked to carcinogenesis and the development of cancer within the human stomach. these include the bacterium helicobacter pylori and the epstein-barr virus. in recent years, there has been increasing evidence that within the human gastrointestinal tract it is not only pathogenic microbes that impact human health but also the corresponding autochthonous microbial communities. thi ... | 2017 | 28501083 |
| anti-helicobacter pylori activity of isocoumarin paepalantine: morphological and molecular docking analysis. | the helicobacterpylori bacterium is one of the main causes of chronic gastritis, peptic ulcers, and even gastric cancer. it affects an average of half of the world population. its difficult eradication depends upon multi-drug therapy. since its classification as a group 1 carcinogenic by international agency for research on cancer (iarc), the importance of h. pylori eradication has obtained a novel meaning. there is considerable interest in alternative therapies for the eradication of h. pylori ... | 2017 | 28498343 |
| systematic review with meta-analysis: the efficacy of vonoprazan-based triple therapy on helicobacter pylori eradication. | in order to increase eradication rates, vonoprazan, a novel potassium-competitive acid blocker, has been used in helicobacter pylori eradication therapy. | 2017 | 28497487 |
| malt lymphoma of minor salivary glands in a sjögren's syndrome patient: a case report and review of literature. | sjögren's syndrome is a chronic systemic disease, characterized by lymphocytic infiltration and destruction mainly of the salivary and lacrimal glands, resulting in xerostomia and xeropthalmia. sjögren's syndrome patients have a 44-fold excess risk for the development of non-hodgkin's lymphoma particularly mucosa-associated lymphoid tissue (malt) lymphoma, prevalently affecting the major salivary glands. in this report, a rare case of malt lymphoma of minor salivary glands in a patient with sjög ... | 2017 | 28496965 |
| helicobacter pylori-derived extracellular vesicles increased in the gastric juices of gastric adenocarcinoma patients and induced inflammation mainly via specific targeting of gastric epithelial cells. | evidence indicates that helicobacter pylori is the causative agent of chronic gastritis and perhaps gastric malignancy. extracellular vesicles (evs) play an important role in the evolutional process of malignancy due to their genetic material cargo. we aimed to evaluate the clinical significance and biological mechanism of h. pylori evs on the pathogenesis of gastric malignancy. we performed 16s rdna-based metagenomic analysis of gastric juices either from endoscopic or surgical patients. from e ... | 2017 | 28496197 |
| sex-differences in the prevalence of helicobacter pylori infection in pediatric and adult populations: systematic review and meta-analysis of 244 studies. | the main outcome of helicobacter pylori infection, i.e. gastric cancer, is more frequent in men, but there is no comprehensive synthesis of the evidence on a potential role of sex in the acquisition and/or persistence of infection. | 2017 | 28495503 |
| gastrokine mrna expression in gastric tissue from dogs with helicobacter colonisation but without inflammatory change during treatment. | gastrokines (gkns) are bioactive substances secreted by gastric cells. evidence supports functional roles for gkns in gastric homeostasis, immune responses and tumour suppression. down-regulation has been reported in helicobacter pylori associated gastritis and other inflammatory gastrointestinal conditions in mice and people. the aim of this study was to evaluate gkn gene expression in dogs positive for other helicobacter spp. both before and after treatment. expression of gkn-1 and gkn-2 mrna ... | 2017 | 28494926 |
| the association between vaca or caga status and eradication outcome of helicobacter pylori infection: a meta-analysis. | h. pylori virulence factors, especially vaca and caga are important in gastroduodenal disease pathogenesis and affect cure rates. this meta-analysis aimed to clarify the association between vaca or caga status and eradication outcome of h. pylori infection. | 2017 | 28493953 |
| local genes for local bacteria: evidence of allopatry in the genomes of transatlantic campylobacter populations. | the genetic structure of bacterial populations can be related to geographical locations of isolation. in some species, there is a strong correlation between geographical distance and genetic distance, which can be caused by different evolutionary mechanisms. patterns of ancient admixture in helicobacter pylori can be reconstructed in concordance with past human migration, whereas in mycobacterium tuberculosis it is the lack of recombination that causes allopatric clusters. in campylobacter, anal ... | 2017 | 28493321 |
| dietary pufa increase apoptosis in stomach of patients with dyspeptic symptoms and infected with h. pylori. | drug-resistant strains of helicobacter pylori and poor treatment response are the main reasons for the failure in eradicating it in patients. polyunsaturated fatty acids (pufa) have an inhibitory effect on bacterial growth. the aim of this study was to investigate the effect of pufa in combination with standard triple therapy on apoptosis in h. pylori infected subjects with dyspeptic symptoms. this study was a double-blind clinical trial in which 34 h. pylori infected subjects with dyspeptic sym ... | 2017 | 28493185 |
| curcumin in combination with triple therapy regimes ameliorates oxidative stress and histopathologic changes in chronic gastritis-associated helicobacter pylori infection. | helicobacter pylori (h. pylori) gastric infection is a main cause of inflammatory changes and gastric cancers. | 2017 | 28492711 |
| hashimoto's thyroiditis and autoimmune gastritis. | the term "thyrogastric syndrome" defines the association between autoimmune thyroid disease and chronic autoimmune gastritis (cag), and it was first described in the early 1960s. more recently, this association has been included in polyglandular autoimmune syndrome type iiib, in which autoimmune thyroiditis represents the pivotal disorder. hashimoto's thyroiditis (ht) is the most frequent autoimmune disease, and it has been reported to be associated with gastric disorders in 10-40% of patients w ... | 2017 | 28491051 |
| [validation of the rapid urease test for the detection of helicobacter pylori in a peruvian hospital]. | to validate a rapid urease test (rut) in cayetano heredia hospital (hch) in lima, peru. | 2017 | 28489837 |
| muc1, muc5ac, and muc6 polymorphisms, helicobacter pylori infection, and gastric cancer: a systematic review and meta-analysis. | the risk of helicobacter pylori (hp) infection, as well as gastric cancer (gc), in association with genetic polymorphisms of gene encoding for mucins, has been investigated with contradictory results. we carried out this systematic review and meta-analysis to summarize the relationship between muc1, muc5ac, and muc6 polymorphisms and hp infection, as well as gc risk. we searched medline, isi web of science, scopus bibliographic databases and the huge navigator database. odds ratios (ors) and 95% ... | 2017 | 28489708 |
| antitumoral potential, antioxidant activity and carotenoid content of two southern italy tomato cultivars extracts: san marzano and corbarino. | gastric cancer represents a diffuse and aggressive neoplasm, whose mortality index is among the highest in the world. predisposing factors are e-cadherin mutations, helicobacter pylori infection, and a diet rich in salted and smoked food, with a low intake of fresh fruits and vegetables. here, we analyzed the effect of total lipophilic extracts of two southern italy tomato varieties, san marzano and corbarino, on an in vitro model of gastric cancer, ycc-1, ycc-2 and ycc-3 cell lines, characteriz ... | 2017 | 28488765 |
| association of obesity with helicobacter pylori infection: a retrospective study. | to explore the association between helicobacter pylori (h. pylori) infection and obesity/weight gain in a chinese population. | 2017 | 28487612 |
| preanalytical stability of antibodies to pathogenic antigens. | background: serologic testing for antibodies against epitopes from pathogens is a valuable tool for investigating the relationship between infection and disease. this study comprehensively evaluates the impact of preanalytic variation on antibody seropositivities to a selected set of antigens arising from delays in processing of blood samples, preprocessing storage temperature, and vacutainer type.methods: we assessed peripheral blood collected from 29 volunteers in four different vacutainer typ ... | 2017 | 28483968 |
| evaluation of diagnostic accuracy of two rapid stool antigen tests using an immunochromatographic assay to detect helicobacter pylori. | the stool antigen assay for h. pylori infection diagnosis with monoclonal antibodies is a simple and recommended technique by the maastricht v/florence consensus report. recently, pylori k-set k-1219 (coris bioconcept sprl, belgium) and hp-f23 (symbiosys, brazil) have been made commercially available in brazil. thus, the aim of this study was to evaluate the diagnostic accuracies of these two rapid stool antigen tests by immunochromatographic assays (index tests) for the clinical practice. | 2017 | 28483407 |
| membrane-bound β-catenin degradation is enhanced by ets2-mediated siah1 induction in helicobacter pylori-infected gastric cancer cells. | β-catenin has two different cellular functions: intercellular adhesion and transcriptional activity. the e3 ubiquitin ligase siah1 causes ubiquitin-mediated degradation of the cytosolic β-catenin and therefore, impairs nuclear translocation and oncogenic function of β-catenin. however, the effect of siah1 on the cell membrane bound β-catenin has not been studied. in this study, we identified that the carcinogenic bacterium h. pylori increased ets2 transcription factor-mediated siah1 protein expr ... | 2017 | 28481365 |
| quercetin from polygonum capitatum protects against gastric inflammation and apoptosis associated with helicobacter pylori infection by affecting the levels of p38mapk, bcl-2 and bax. | helicobacter pylori-associated gastritis is a major threat to public health and polygonum capitatum (pc) may have beneficial effects on the disease. however, the molecular mechanism remains unknown. quercetin was isolated from pc and found to be a main bioactive compound. the effects of quercetin on human gastric cancer cells ges-1 were determined by xcelligence. h. pylori-infected mouse models were established. all mice were divided into three groups: control (cg, healthy mice), model (mg, h. p ... | 2017 | 28481232 |
| heme proximal hydrogen bonding between his170 and asp132 plays an essential role in the heme degradation reaction of hutz from vibrio cholerae. | hutz from vibrio cholerae is an enzyme that catalyzes the oxygen-dependent degradation of heme. the crystal structure of the homologous protein from helicobacter pylori, hugz, predicts that asp132 in hutz is located within hydrogen-bonding distance of the heme axial ligand his170. hydrogen bonding between his170 and asp132 appears to be disfavored in heme-degrading enzymes, because it can contribute to the imidazolate character of the axial histidine, as observed in most heme-containing peroxida ... | 2017 | 28481076 |
| inhibitory activity of mangiferin on helicobacter pylori-induced inflammation in human gastric carcinoma ags cells. | gastric cancer is a serious health issue caused by h. pylori and claims more lives in developing and undeveloped countries. hence, the need for a natural drug with several pharmacological activities with no adverse effect are highly recommended. the target of this study was to verify the anti-h. pyloric efficacy of mangiferin (mf) on h. pylori-infected ags cells. | 2017 | 28480404 |
| evaluation of the antioxidant properties of carexanes in ags cells transfected with the helicobacter pylori's protein hspb. | naturally derived compounds represent a potential source of pharmacologically active drugs able to contrast different diseases, including gastric cancer, a multifactorial disease, in which the important role played by h. pylori infection has been demonstrated. carexanes, stilbene derivatives, isolated from plants of the carex distachya desf., are unusual secondary metabolites with a tetracyclic skeleton arising from a cyclization of prenylstilbenoid precursors. in this study we firstly showed th ... | 2017 | 28479510 |
| novel aspects of defensins' involvement in virus-induced autoimmunity in the central nervous system. | recent research on re-circulation of interstitial fluid from the brain parenchyma to the periphery and its inferred importance in immune surveillance dysregulation are changing our conceptualization of the pathophysiology of virus-induced autoimmunity. in this context, it is necessary to reassess the immunomodulatory properties of human defensins that are variably expressed by cerebral microglia, astrocytes and choroid plexus epithelial cells and exhibit complex and often confounding roles in ne ... | 2017 | 28478826 |
| h. pylori modifies methylation of global genomic dna and the gastrin gene promoter in gastric mucosal cells and gastric cancer cells. | the aim of this study was to evaluate the correlation between h. pylori infection and global dna methylation, as well as the methylation levels of the gastrin promoters. | 2017 | 28478202 |
| synergistic effect of hyperglycemia and helicobacterpylori infection status on colorectal adenoma risk. | both helicobacter pylori and type 2 diabetes mellitus are possible risk factors for colon adenoma. | 2017 | 28475740 |
| is a multidisciplinary aerodigestive clinic more effective at treating recalcitrant aerodigestive complaints than a single specialist? | to determine the utility of a pediatric multidisciplinary aerodigestive clinic (adc) in treating recalcitrant aerodigestive conditions. | 2017 | 28474959 |
| obesity and helicobacter pylori: an undefined association. | 2017 | 28474842 | |
| conjunctival tumors: review of clinical features, risks, biomarkers, and outcomes--the 2017 j. donald m. gass lecture. | conjunctival tumors encompass a broad range of diagnoses. the 3 most important malignant tumors include ocular surface squamous neoplasia (ossn) (14%), melanoma (12%), and lymphoma (7%). conjunctival malignancies are rarely found in children. regarding ossn, pre-disposing conditions include chronic solar radiation, immune deficiency (hiv), organ transplant, autoimmune conditions, xeroderma pigmentosum, and chronic exposure to cigarette smoke. ossn is managed surgically or with topical/injection ... | 2017 | 28399347 |
| biochemical and genetic analysis of the chlamydia groel chaperonins. | chaperonins are essential for cellular growth under normal and stressful conditions and consequently represent one of the most conserved and ancient protein classes. the paradigm escherichia coli chaperonin, ecgroel, and its cochaperonin, ecgroes, assist in the folding of proteins via an atp-dependent mechanism. in addition to the presence of groel and groes homologs, groel paralogs are found in many bacteria, including pathogens, and have evolved poorly understood species-specific functions. ch ... | 2017 | 28396349 |
| a significant increase in the pepsinogen i/ii ratio is a reliable biomarker for successful helicobacter pylori eradication. | helicobacter pylori (h. pylori) eradication is usually assessed using the 13c-urea breath test (ubt), anti-h. pylori antibody and the h. pylori stool antigen test. however, a few reports have used pepsinogen (pg), in particular, the percentage change in the pg i/ii ratio. here, we evaluated the usefulness of the percentage changes in serum pg i/ii ratios for determining the success of eradication therapy for h. pylori. | 2017 | 28854276 |
| helicobacter pylori saba gene is associated with iron deficiency anemia in childhood and adolescence. | gastric helicobacter pylori colonization leads to iron deficiency anemia (ida), especially in children and adolescents. however the pathogenesis is poorly understood. | 2017 | 28854239 |
| corrigendum: in situ targeted mri detection of helicobacter pylori with stable magnetic graphitic nanocapsules. | this corrects the article doi: 10.1038/ncomms15653. | 2017 | 28853437 |
| vaca and caga genotypes of helicobacter pylori isolated from raw meat in isfahan province, iran. | foods with animal origins play a substantial role in the transmission of helicobacter pylori. the present investigation was carried out to study the vaca and caga genotypes status of h. pylori isolated from various types of meat samples. two hundred and twenty meat samples were collected and cultured. h. pylori-positive strains were analyzed for the presence of vaca and caga genotypes. eleven out of 220 (5.00%) samples were positive for h. pylori. findings were confirmed by nested pcr. prevalenc ... | 2017 | 28473901 |
| epidermal growth factor receptor inhibition downregulates helicobacter pylori-induced epithelial inflammatory responses, dna damage and gastric carcinogenesis. | gastric cancer is the third leading cause of cancer death worldwide and infection by helicobacter pylori is the strongest risk factor. we have reported increased epidermal growth factor receptor (egfr) phosphorylation in the h. pylori-induced human carcinogenesis cascade, and association with dna damage. our goal was to determine the role of egfr activation in gastric carcinogenesis. | 2017 | 28473630 |
| structural diversity of human gastric mucin glycans. | the mucin o-glycosylation of 10 individuals with and without gastric disease was examined in depth in order to generate a structural map of human gastric glycosylation. in the stomach, these mucins and their o-glycosylation protect the epithelial surface from the acidic gastric juice and provide the first point of interaction for pathogens such as helicobacter pylori, reported to cause gastritis, gastric and duodenal ulcers and gastric cancer. the rational of the present study was to map the o-g ... | 2017 | 28461410 |
| [levofloxacin-based triple therapy versus bismuth-based quadruple therapy in the treatment of helicobacter pylori as the rescue therapy: a meta analysis]. | objective: to evaluate the efficacy of levofloxacin-based triple therapy and bismuth-based quadruple therapy in the treatment of helicobacter pylori (hp) infection as rescue regimens. methods: related randomized controlled trials assessing the efficacy and safety of levofloxacin-based triple therapy eradicating hp as salvage treatment were retrieved from pubmed, cochrane library, springer, vip database, wanfang database and ckni database. the literature quality was evaluated by the improved jada ... | 2017 | 28460509 |
| [therapies for helicobacter pylori from a different perspective]. | 2017 | 28460500 | |
| [advantages and disadvantages of helicobacter pylori eradication in chinese patients]. | 2017 | 28460499 | |
| risk factors for upper gastrointestinal bleeding in patients taking selective cox-2 inhibitors: a nationwide population-based cohort study. | cyclooxygenase-2 inhibitors (coxibs) are associated with less upper gastrointestinal bleeding (ugib) than traditional nonsteroidal anti-inflammatory drugs (tnsaids). however, they also increase the risk of ugib in high-risk patients. we aimed to identify the risk factors of ugib in coxibs users. | 2017 | 28460044 |
| inverse correlation between helicobacter pylori colonization and pediatric overweight: a preliminary study. | helicobacter pylori, one of the most common bacterial pathogens in humans, is generally acquired during childhood. the inverse correlation between h. pylori colonization and obesity that was found in adults has not been investigated in depth in children. our aim was to assess the correlation between overweight and obesity and h. pylori colonization in a pediatric population. | 2017 | 28459602 |