Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| time-integrative passive sampling combined with toxicity profiling (tiptop): an effect-based strategy for cost-effective chemical water quality assessment. | this study aimed at demonstrating that effect-based monitoring with passive sampling followed by toxicity profiling is more protective and cost-effective than the current chemical water quality assessment strategy consisting of compound-by-compound chemical analysis of selected substances in grab samples. passive samplers were deployed in the dutch river delta and in wwtp effluents. their extracts were tested in a battery of bioassays and chemically analyzed to obtain toxicity and chemical profi ... | 2018 | 30296657 |
| cost-effectiveness analysis of single use negative pressure wound therapy dressings (snpwt) compared to standard of care in reducing surgical site complications (ssc) in patients undergoing coronary artery bypass grafting surgery. | there is a growing interest in using negative pressure wound therapy in closed surgical incision to prevent wound complications which continue to persist following surgery despite advances in infection measures. | 2018 | 30285811 |
| advanced formulations for intranasal delivery of biologics. | the global biologics market has been ever increasing over the last decades and is predicted to top euro 350 by 2020. facing this scenario, the parenteral route of biologics administration as hitherto standard route is inconvenient for the future. among the alternatives, the intranasal delivery of therapeutic biologicals seems to be most promising but researchers are still facing challenges as indicated by the scarce number of successfully marketed peptide drugs. | 2018 | 30316796 |
| genetic characterization of mycobacterium tuberculosis complex isolates circulating in abuja, nigeria. | nigeria ranks fourth among the high tuberculosis (tb) burden countries. this study describes the prevalence of drug resistance and the genetic diversity of mycobacterium tuberculosis in abuja's federal capital territory. | 2018 | 30319278 |
| diesel exhaust particles induce autophagy and citrullination in normal human bronchial epithelial cells. | a variety of environmental agents has been found to influence the development of autoimmune diseases; in particular, the studies investigating the potential association of systemic autoimmune rheumatic diseases with environmental micro and nano-particulate matter are very few and contradictory. in this study, the role of diesel exhaust particles (deps), one of the most important components of environment particulate matter, emitted from euro 4 and euro 5 engines in altering the normal human bron ... | 2018 | 30341285 |
| accuracy of self-reported heights and weights in a predominately low-income, diverse population living in the usa. | this study explored the accuracy of self-reported heights and weights and factors associated with self-reported bias in a diverse american sample. | 2018 | 30329190 |
| the guatemalan construction industry: approach of knowledge regarding work risks prevention. | in the present work, the results are presented for the characterization of work risk prevention in the guatemalan construction industry. this characterization has been carried out using a simple random sampling technique, employing a questionnaire that was structured into 3 groups of variables: 1. general company data; 2. prevention and management activities regarding health and safety in the company and on the worksite; and 3. health and safety in the contractor companies. following the samplin ... | 2018 | 30326584 |
| authors' correction for euro surveill. 2018;23(39). | 2018 | 30352642 | |
| new epidemic cluster of pre-extensively drug resistant isolates of mycobacterium tuberculosis ural family emerging in eastern europe. | ural genetic family is a part of the euro-american lineage of mycobacterium tuberculosis and is endemic in northern eurasia (former soviet union [fsu]). these strains were long described as drug susceptible and of low virulence, but recent studies reported an increasing circulation of the multidrug-resistant (mdr) and extensively drug-resistant (xdr) ural strains. here, we analyzed all publicly available whole genome sequence data of ural genotype isolates, in order to elucidate their phylogenom ... | 2018 | 30348088 |
| population specific data improves fordisc®'s performance in italians. | using discriminant functions based on morphometric data is one of the most approved methods for sex and ancestry estimation on skeletons. nevertheless, population data from various parts of the world is needed in order to reliably classify an individual into a group. due to population variation even sex estimation is biased when there is a lack of adequate data. software that computes discriminant functions based on morphometric data is fordisc®. unfortunately, the above mentioned effects reduce ... | 2018 | 30342922 |
| impact of pharmacist interventions on clinical outcome and cost avoidance in a university teaching hospital. | background a significant number of clinical pharmacy services have shown to improve in-hospital medication safety and patient outcome. prescription review and pharmacist interventions are a fundamental part of hospital clinical pharmacy activities. in a context of restricted financial resources, proving the economic and clinical impact of this activity seems necessary. objective the aim of this study was to assess the clinical impact on patient outcomes and economic benefit of prescription revie ... | 2018 | 30367375 |
| clinical and economic burden of severe asthma: a french cohort study. | to describe the clinical and economic burden of severe asthma in france over 12 months. | 2018 | 30366583 |
| management of acute heart failure: contribution of daily bedside echocardiographic assessment on therapy adjustment with impact measure on the 30-day readmission rate (jecica). | there are currently one million heart failure (hf) patients in france and the rate is progressively increases due to population aging. acute decompensation of hf is the leading cause of hospitalization in people over 65 years of age with a 25% re-hospitalization rate in the first month. expenses related to the management of hf in france in 2013 amounted to more than one billion euros, of which 65% were for hospitalizations alone. the management of acute decompensation is a challenge, due to the ... | 2018 | 30364633 |
| a randomised controlled trial of long-chain omega-3 polyunsaturated fatty acids in the management of rotator cuff related shoulder pain. | multicentre, double-blind, placebo-controlled randomised clinical trial. | 2018 | 30364577 |
| the economic impact of a switch from prescription-only to non-prescription drugs in italy. | the paper analyses the potential economic impact of switching drugs from prescription-only to over the counter status, using italy as a case-study. the study assumes a societal perspective, investigating the effects of switches (and consequent delisting) on drugs spending, avoided visits by gps (general practitioners) and avoided time spent by patients for these visits. it overcomes the main pitfalls of previous studies, providing a rational for listing switchable products and applying both a st ... | 2018 | 30386233 |
| biomolecular archaeology reveals ancient origins of indigenous tobacco smoking in north american plateau. | chemical analysis of residues contained in the matrix of stone smoking pipes reveal a substantial direct biomolecular record of ancient tobacco (nicotiana) smoking practices in the north american interior northwest (plateau), in an area where tobacco was often portrayed as a euro-american-introduced postcontact trade commodity. nicotine, a stimulant alkaloid and biomarker for tobacco, was identified via ultra-performance liquid chromatography-mass spectrometry in 8 of 12 analyzed pipes and pipe ... | 2018 | 30373836 |
| global variation in bacterial strains that cause tuberculosis disease: a systematic review and meta-analysis. | the host, microbial, and environmental factors that contribute to variation in tuberculosis (tb) disease are incompletely understood. accumulating evidence suggests that one driver of geographic variation in tb disease is the local ecology of mycobacterial genotypes or strains, and there is a need for a comprehensive and systematic synthesis of these data. the objectives of this study were to (1) map the global distribution of genotypes that cause tb disease and (2) examine whether any epidemiol ... | 2018 | 30373589 |
| funds reimbursement of high-cost drugs in gastrointestinal oncology: an italian real practice 1 year experience at the national cancer institute of naples. | introduction: the therapeutic scenario of oncology is enriching of innovative agents which are determining an increase in public expenditure because of their high cost. in italy, a web-based government registry is used to monitor the clinical use of these drugs and, in later phases, to obtain funds reimbursement according to specific economic agreements with companies. methods: a health policy expert pharmacist was included in the multidisciplinary team of the department of abdominal oncology of ... | 2018 | 30370266 |
| [the revenue from finger replantation and revision amputation: is it cost-covering?] | finger amputation injuries are frequently treated conditions in occupational accident hospitals. they are either treated by replantation or revision amputation. the costs of these two treatment options differ significantly. this study aims to determine if the revenue generated from the treatment of finger amputation injuries in the german drg system is cost-covering and if there are differences depending on the type of health insurance. | 2018 | 30404124 |
| higher education at the institut hospitalo-universitaire méditerranée infection. | since its creation in 2011, the institut hospitalo-universitaire méditerranée infection (ihu mi) has devoted a major part of its funding to support higher education programs. in 2017, on a recurrent budget of 5.8 million euros per year, 2.9 (50%) were spent on infrastructure, mostly for maintenance and equipment of our new building. among the remaining 2.9 million euros, 2.3 (80%) have been dedicated to support higher education programs. | 2018 | 30402253 |
| addendum for euro surveill. 2018;23(10). | 2018 | 30401011 | |
| a systematic review of the indirect costs of schizophrenia in europe. | schizophrenia is a chronic disease associated with significant and long-lasting effects on health, and it is also a social and financial burden, not only for patients but also for families, other caregivers, and the wider society. it is essential to conduct the assessment of indirect costs, to understand all the effects of the disease on society. our aim is to gain a better understanding of the indirect costs of schizophrenia in europe. | 2018 | 30395217 |
| a practical method to estimate the benefits of improved road network reliability: an application to departing air passengers. | this paper develops and applies a practical method to estimate the benefits of improved reliability of road networks. we present a general methodology to estimate the scheduling costs due to travel time variability for car travel. in contrast to existing practical methods, we explicitly consider the effect of travel time variability on departure time choices. we focus on situations when only mean delays are known, which is typically the case when standard transport models are used. we first show ... | 2018 | 30393412 |
| costs, outcome and cost-effectiveness of neurocritical care: a multi-center observational study. | neurocritical illness is a growing healthcare problem with profound socioeconomic effects. we assessed differences in healthcare costs and long-term outcome for different forms of neurocritical illnesses treated in the intensive care unit (icu). | 2018 | 30236140 |
| a randomized comparison of three data collection models for the measurement of parent experiences with diabetes outpatient care. | the objective of this study was to compare three data collection methods for the measurement of parent experiences with hospital outpatient care for child and adolescent diabetes, based on a randomised national trial in norway involving both pen-and-paper and electronic response options. | 2018 | 30236067 |
| role of incentives in long-term nutritional and growth studies in children. | available published advice on use of incentives is limited and generally refers to short-term studies without longer follow-up, predominantly conducted in developed countries. we aim to summarize published information related to the use of incentives in long-term nutrition studies involving infants, children, and adolescents and the views of researchers in the field, to provide guidance on acceptable incentives. we conducted a literature review and a short online survey of researchers regarding ... | 2018 | 30234757 |
| extra cost of brain metastases (bm) in patients with non-squamous non-small cell lung cancer (nsclc): a french national hospital database analysis. | to assess the incremental cost associated with the management of patients with primary non-squamous non-small cell lung cancer (nsclc) with brain metastases at the time of diagnosis. | 2018 | 30233822 |
| cost-consequence analysis of fluticasone furoate/vilanterol 92/22 mcg for the management of copd in the spanish nhs. | the salford lung study in chronic obstructive pulmonary disease (sls copd) is a 12-month, open-label randomized clinical trial comparing clinical effectiveness and safety of initiating once-daily fluticasone furoate/vilanterol (ff/vi) 92/22 mcg with continuing usual care (uc) in patients with copd followed in primary care in the uk. the objective of this analysis is to estimate the economic impact of these results when applied to spain. | 2018 | 30233222 |
| evaluation of the capillary assay of c-reactive protein (crp) through the lenght of consultation in pediatric emergencies and its economic impact. | fever is a frequent reason for consultation in pediatric emergency departments and raises the question of biological and radiological examinations. rapidly obtaining the result of c-reactive protein (crp) level is essential in front of the steady increase of the number of visits. we carried out a prospective study within the pediatric emergency department of the university hospital of clermont-ferrand from january to april 2017, in order to evaluate the interest of the capillary crp in point of ... | 2018 | 30226196 |
| molecular epidemiology and drug resistance patterns of mycobacterium tuberculosis complex isolates from university students and the local community in eastern ethiopia. | previous studies suggest the burden of pulmonary tuberculosis (ptb) in ethiopia may be greater in university students relative to the overall population. however, little is known about the transmission dynamics of ptb among students and members of the communities surrounding university campuses in eastern ethiopia. | 2018 | 30222743 |
| factors influencing the scientific performance of momentum grant holders: an evaluation of the first 117 research groups. | the momentum program launched in 2009 provides funding of up to 1 million euro to establish new, independent research groups at hungarian academic institutions. here, our aim was to determine factors associated with the scientific output of these research groups. publication data were downloaded from the hungarian scientific work archive (www.mtmt.hu), impact factor data were obtained from thomson reuters (jcr.incites.thomsonreuters.com), and journal ranks were extracted from the scimago journal ... | 2018 | 30220748 |
| fifth euro-asian congress of dermatovenereologists, riga, latvia. | 2018 | 30209860 | |
| labour productivity loss caused by premature deaths associated with breast cancer: results from spain over a 10-year period. | breast cancer is one of the most common cancers among women worldwide, and is the most common cause of cancer deaths in them. given that such disease has a significant impact on middle-aged women, it can result in considerable labour productivity losses. the main objective of this study is therefore to analyse labour productivity losses and years of potential working life lost as a result of premature deaths from breast cancer in spain over a 10-year period (2005-2014). | 2018 | 30209732 |
| budget impact of implementing platelet pathogen reduction into the italian blood transfusion system. | despite improvements in blood donor selection and screening procedures, transfusion recipients can still develop complications related to infections by known and emerging pathogens. pathogen reduction technologies (prt) have been developed to reduce such risks. the present study, developed whithin a wider health technology assessment (hta) process, was undertaken to estimate the costs of the continuing increase in the use of platelet prt in italy. | 2018 | 30201081 |
| top-down nox emissions of european cities based on the downwind plume of modelled and space-borne tropospheric no₂ columns. | top-down estimates of surface nox emissions were derived for 23 european cities based on the downwind plume decay of tropospheric nitrogen dioxide (no₂) columns from the lotos-euros (long term ozone simulation-european ozone simulation) chemistry transport model (ctm) and from ozone monitoring instrument (omi) satellite retrievals, averaged for the summertime period (april⁻september) during 2013. here we show that the top-down nox emissions derived from lotos-euros for european urban areas agree ... | 2018 | 30200378 |
| the long-term impact of employment bans on the economic integration of refugees. | many european countries impose employment bans that prevent asylum seekers from entering the local labor market for a certain waiting period upon arrival. we provide evidence on the long-term effects of these employment bans on the subsequent economic integration of refugees. we leverage a natural experiment in germany, where a court ruling prompted a reduction in the length of the employment ban. we find that, 5 years after the waiting period was reduced, employment rates were about 20 percenta ... | 2018 | 30255139 |
| recent advances on the multiplex molecular detection of plant viruses and viroids. | plant viruses are still one of the main contributors to economic losses in agriculture. it has been estimated that plant viruses can cause as much as 50 billion euros loss worldwide, per year. this situation may be worsened by recent climate change events and the associated changes in disease epidemiology. reliable and early detection methods are still one of the main and most effective actions to develop control strategies for plant viral diseases. during the last years, considerable progress h ... | 2018 | 30250456 |
| air stagnation in europe: spatiotemporal variability and impact on air quality. | this paper characterizes the spatiotemporal variability of air stagnation over the euro-mediterranean area for the 1979-2016 period by using a simplified air stagnation index (asi) based on daily precipitation as well as near-surface and upper wind speed data. we have also undertaken the first comparison of stagnation as derived from meteorological reanalysis and observations, finding a reasonably good agreement between both datasets. the main differences arise from the surface wind speed, as th ... | 2018 | 30248849 |
| flavone constituents of phlomis bruguieri desf. with cytotoxic activity against mcf-7 breast cancer cells. | phlomis bruguieri (p. bruguieri) is a large genus in the lamiaceae family, with a wide variety distributed in euro-asia, central asia, iran, and china. phlomis flowers have been used as herbal tea for gastrointestinal disturbances, protection of liver and cardiovascular systems. the aim of this study was to analyse phytochemical of flavonoid constituents in semi polar fraction of p. bruguieri. methanol extract of plant material (4 kg) yielded 361 g dark green concentrated extract gum. after prel ... | 2018 | 30271444 |
| safety and efficacy of switching from branded to generic imatinib in chronic phase chronic myeloid leukemia patients treated in italy. | the use of generic drugs after patent expiration of their originators is a relative novelty in the treatment of chronic cancer patients in western countries. in this observational study we analyzed a cohort of 294 italian chronic phase chronic myeloid leukemia patients treated frontline with branded imatinib (glivec®) for at least 6 months and then uniformly switched to generic imatinib upon requirement of health authorities in early 2017. median age at diagnosis was 57 years (range 19-87). soka ... | 2018 | 30308414 |
| social economic costs of copd in extremadura (spain): an observational study. | copd has been associated with a high number of comorbidities and a relatively high level of health care resource utilization. this study aimed to estimate the social economic impact of copd in the autonomous community of extremadura (spain) in 2015. | 2018 | 30174420 |
| quantifying the burden of stillbirths before 28 weeks of completed gestational age in high-income countries: a population-based study of 19 european countries. | international comparisons of stillbirth allow assessment of variations in clinical practice to reduce mortality. currently, such comparisons include only stillbirths from 28 or more completed weeks of gestational age, which underestimates the true burden of stillbirth. with increased registration of early stillbirths in high-income countries, we assessed the reliability of including stillbirths before 28 completed weeks in such comparisons. | 2018 | 30269877 |
| barcoding of chrysomelidae of euro-mediterranean area: efficiency and problematic species. | leaf beetles (coleoptera: chrysomelidae), with more than 37,000 species worldwide and about 2,300 in the euro-mediterranean region, are an ecological and economical relevant family, making their molecular identification of interest also in agriculture. this study, part of the mediterranean chrysomelidae barcoding project (www.c-bar.org), aims to: (i) develop a reference cytochrome c oxidase i (coi) library for the molecular identification of the euro-mediterranean chrysomelidae; (ii) test the ef ... | 2018 | 30194432 |
| high-dose chemotherapy and blood autologous stem-cell rescue compared with standard chemotherapy in localized high-risk ewing sarcoma: results of euro-e.w.i.n.g.99 and ewing-2008. | purpose for over 30 years, the place of consolidation high-dose chemotherapy in ewing sarcoma (es) has been controversial. a randomized study was conducted to determine whether consolidation high-dose chemotherapy improved survival in patients with localized es at high risk for relapse. methods randomization between busulfan and melphalan (bumel) or standard chemotherapy (vincristine, dactinomycin, and ifosfamide [vai], seven courses) was offered to patients if they were younger than 50 years of ... | 2018 | 30188789 |
| induced negative mood increases dictator game giving. | the study examines the influence of induced negative mood on dictator game giving (dgg) with two recipients. participants (n = 63) played the role of a dictator in a three-player dictator game. they could choose among two options: an altruistic option, where two receivers receive 10 euros and the dictator himself receives nothing, or a selfish option, where the dictator himself receives 5 euros and both receivers receive nothing. for half of the participants, the second option entailed that only ... | 2018 | 30186212 |
| incidence and cost of perioperative red blood cell transfusion for elective spine fusion in a high-volume center for spine surgery. | spine fusion is a surgical procedure characterized by a significant perioperative bleeding, which often requires red blood cell (rbc) transfusion. | 2018 | 30185155 |
| prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in europe-the euro-epime study from the european network euromene: a protocol for a systematic review. | myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs) is a chronic disease involving central nervous system and immune system disorders, as well as cardiovascular abnormalities. me/cfs is characterised by severe chronic fatigue lasting for at least 6 months, including clinical symptoms such as tender cervical or axillary lymph nodes, muscle pain, joint pain without swelling or redness, post-exertional malaise for more than 24 hours and unrefreshing sleep. studies on the epidemiology of me/ ... | 2018 | 30181183 |
| effectiveness and cost of contraception in france (facet study): a cohort study from the french national healthcare insurance database. | to assess the effectiveness and costs associated with contraceptive methods based on real-world data in france. | 2018 | 30176517 |
| subcutaneous specific immunotherapy: economic implications from the perspective of statutory health insurance - a population based cost-effectiveness estimation. | specific immunotherapy is the only potentially curative therapy in patients with allergic rhinitis (ar) and allergic asthma (aa). the present study examined the effects of subcutaneous immunotherapy (scit) on the financial situation of the german statutory health insurance systems and measures the impact on ar/aa prevalence during the next decades. a further objective was to identify possible scit-treatment strategies in order to reach an efficient scit-use. | 2018 | 31826032 |
| overconfidence is universal? elicitation of genuine overconfidence (ego) procedure reveals systematic differences across domain, task knowledge, and incentives in four populations. | overconfidence is sometimes assumed to be a human universal, but there remains a dearth of data systematically measuring overconfidence across populations and contexts. moreover, cross-cultural experiments often fail to distinguish between placement and precision and worse still, often compare population-mean placement estimates rather than individual performance subtracted from placement. here we introduce a procedure for concurrently capturing both placement and precision at an individual leve ... | 2018 | 30161140 |
| cognition and its association with the factors of the euro-d: suffering and motivation. findings from share wave 6. | the aims of this study were (1) to analyse the relationship between cognition and clinical and sociodemographic variables, (2) to explore the relationship between cognitive tests and factors of euro-d depression scale (suffering and motivation), and (3) to determine the relevance of cognition with respect to clinical and sociodemographic variables in the scores of the euro-d factors. | 2018 | 30159923 |
| ammonia emission measurements for light-duty gasoline vehicles in china and implications for emission modeling. | motor vehicle ammonia (nh3) emissions have attracted increasing attention for their potential to form secondary aerosols in urban atmospheres. however, vehicle nh3 emission factors (efs) remain largely unknown due to a lack of measurements. thus, we conducted detailed measurements of nh3 emissions from 18 euro 2 to euro 5 light-duty gasoline vehicles (ldgvs) in shanghai, china. the distance- and fuel-based nh3 efs average 29.2 ± 24.1 mg·km-1 and 0.49 ± 0.41 g·kg-1, respectively. the average nh3- ... | 2018 | 30157650 |
| effects of four prototype gasoline particle filters (gpfs) on nanoparticle and genotoxic pah emissions of a gasoline direct injection (gdi) vehicle. | the fast replacement of traditional gasoline port-fuel injection technology with gasoline direct-injection (gdi) vehicles is expected to have a substantial impact on urban air quality. herein we report on effects of four prototype gasoline particle filters (gpfs) on exhausts of a 1.6 l euro-5 gdi vehicle. two noncoated and two filters with catalytic coatings were investigated. these filters, on average, lowered pn emissions 4-7-fold to 4.0-6.8 × 1011 particles/km. genotoxic pahs were lowered 2-5 ... | 2018 | 30149706 |
| global bioethics: a story of dreams and doubts from bengal. | this article is concerned with the practice of bioethics outside of the euro-american and anglophone settings in which it was first formulated. in theoretical terms, the article considers the frictions that arise when global-scale projects such as bioethics are introduced into diverse social and cultural settings. methodologically, the article is constructed around the biography of an indian medical educator trained in bioethics and working to promote the subdiscipline in the indian context. the ... | 2018 | 30146520 |
| a clinical careography: steering life-and-death decisions through care. | in many euro-american societies, the ideal of patient and family involvement in clinical decision-making prevails. this ideal exists alongside the doctor's obligation and responsibility to make decisions and to be accountable for them. in this article, we explore how medical staff navigate the tension between autonomy and authority when engaging life-and-death decision-making in a danish nicu. | 2018 | 30171142 |
| cost-effectiveness of a blended physiotherapy intervention compared to usual physiotherapy in patients with hip and/or knee osteoarthritis: a cluster randomized controlled trial. | blended physiotherapy, in which physiotherapy sessions and an online application are integrated, might support patients in taking an active role in the management of their chronic condition and may reduce disease related costs. the aim of this study was to evaluate the cost-effectiveness of a blended physiotherapy intervention (e-exercise) compared to usual physiotherapy in patients with osteoarthritis of hip and/or knee, from the societal as well as the healthcare perspective. | 2018 | 30170586 |
| eu health systems classification: a new proposal from euro-healthy. | in accordance the who framework of health system functions and by using the indicators collected within the euro-healthy project, this work aims to contribute to the discussion on the classification of eu health systems. | 2018 | 29970085 |
| correction to: the euro-forta (fit for the aged) list: international consensus validation of a clinical tool for improved drug treatment in older people. | in the original publication of this article, the members of the forta group were provided in such a way that they could not be indexed as collaborators on pubmed. the article should have included an acknowledgement section as shown below. | 2018 | 29968139 |
| drivers of cost in adult thoracolumbar spine deformity surgery. | in an era of rising health care costs, it is prudent to consider effective use of resources. given the rapidly expanding elderly population with an anticipated increase in adult spinal deformity, identifying the significant cost drivers for the surgical management is an important step in the process of increasing sustainability and cost-effectiveness of adult spinal deformity surgery. | 2018 | 29966783 |
| chyle leak after pancreatic surgery: validation of the international study group of pancreatic surgery classification. | chyle leak is an uncommon complication after pancreatic surgery. the chyle leak incidence, definition, diagnosis, and treatment had been reported heterogeneously so far. recently a consensus definition and grading system was published by the international study group for pancreatic surgery. this study aims to evaluate the differences in the clinical and economic burden of chyle leak applying the new definition. | 2018 | 29958728 |
| effect of systemic hypertension with versus without left ventricular hypertrophy on the progression of atrial fibrillation (from the euro heart survey). | hypertension is a risk factor for both progression of atrial fibrillation (af) and development of af-related complications, that is major adverse cardiac and cerebrovascular events (macce). it is unknown whether left ventricular hypertrophy (lvh) as a consequence of hypertension is also a risk factor for both these end points. we aimed to assess this in low-risk af patients, also assessing gender-related differences. we included 799 patients from the euro heart survey with nonvalvular af and a b ... | 2018 | 29958714 |
| system based on thermal control of the hcci technology developed for reduction of the vehicle nox emissions in order to fulfil the future standard euro 7. | on the present the environmental protection belongs among the most important worldwide priorities. from this reason there is valid within the framework of the european union the standard euro, which is specifically defined in the transport area. nowadays the actual issue of this standard is signed euro 6. it is established in order to eliminate most of the undesirable air pollutants. however, there is already prepared a new and even stricter emission standard euro 7. it is a well-known fact that ... | 2018 | 29957432 |
| wishes and preferences for an online lifestyle program for brain health-a mixed methods study. | individuals with subjective cognitive decline (scd) are at increased risk of alzheimer's disease and could benefit from a prevention strategy targeting lifestyle factors. making a program available through the internet gives a widespread reach at low cost, but suboptimal adherence is a major threat to effectiveness. as a first step in developing an online lifestyle program (olp), we aimed to identify factors that are barriers and/or facilitators for the use of an olp in individuals with scd in t ... | 2018 | 29955658 |
| systematic review of the cost-effectiveness of preoperative antibiotic prophylaxis in reducing surgical-site infection. | surgical-site infections (ssis) increase the length of hospital admission and costs. ssi prevention guidelines include preoperative antibiotic prophylaxis. this review assessed the reporting quality and cost-effectiveness of preoperative antibiotics used to prevent ssi. | 2018 | 29951632 |
| interventional treatment of paravalvular regurgitation by plug implantation following prosthetic valve replacement: a single-center experience. | interventional closure of paravalvular leaks (pvl) by plug implantation has emerged as an alternative to surgical correction, which is associated with high mortality rates for re-operation. to date, data on procedural efficacy and clinical outcome after transcatheter closure is sparse. we present our experience with interventional pvl closure at our site. | 2018 | 29948288 |
| house dust mite-related respiratory allergies and probiotics: a narrative review. | the socio-economic burden of allergic respiratory conditions on continental europe is even higher than that of mainstream diseases, such as diabetes and cardiovascular disease, as allergic rhinitis alone accounts for billions of euros in healthcare expenses across europe. house dust mites (hdm) are one of the most common triggers behind allergic rhinitis and asthma. the role of probiotics in the treatment and prevention of some allergic conditions, such as atopic dermatitis, is already well reco ... | 2018 | 29946225 |
| transcatheter aortic valve replacement with the 34 mm medtronic evolut valve : early results of single institution experience. | to report our experience with the recently introduced 34 mm evolut transcatheter aortic valve replacement (tavr) prosthesis. | 2018 | 29943115 |
| impacts and uncertainties of +2°c of climate change and soil degradation on european crop calorie supply. | even if global warming is kept below +2°c, european agriculture will be significantly impacted. soil degradation may amplify these impacts substantially and thus hamper crop production further. we quantify biophysical consequences and bracket uncertainty of +2°c warming on calories supply from 10 major crops and vulnerability to soil degradation in europe using crop modeling. the environmental policy integrated climate (epic) model together with regional climate projections from the european bra ... | 2018 | 29938209 |
| cost-effectiveness and budget impact of treatment with evolocumab versus statins and ezetimibe for hypercholesterolemia in spain. | to analyze the cost-effectiveness ratio and budget impact of treatment with evolocumab (pcsk9 inhibitor) for patients in secondary prevention in the spanish national health system. | 2018 | 29937273 |
| low-cost, self-made cad/cam-guiding system for mandibular reconstruction. | facial symmetry, as well as function, remains the big challenge for surgeons who attempt mandibular reconstruction. nowadays several studies recommend the use of computer aided surgery (cas) and cad/cam technology to guide mandibular segmental osteotomies and reconstruction using free fibula flap. although these systems have radically changed the way of doing mandibular reconstructive surgery, they are expensive and require extended periods of time for prototypation. this may be an important lim ... | 2018 | 29937172 |
| road anomalies detection system evaluation. | anomalies on road pavement cause discomfort to drivers and passengers, and may cause mechanical failure or even accidents. governments spend millions of euros every year on road maintenance, often causing traffic jams and congestion on urban roads on a daily basis. this paper analyses the difference between the deployment of a road anomalies detection and identification system in a “conditioned” and a real world setup, where the system performed worse compared to the “condition ... | 2018 | 29933596 |
| reduction of the nox emissions in vehicle diesel engine in order to fulfill future rules concerning emissions released into air. | in the past period occurred information about a fact that in some of the motorcars was installed a software, which enabled to hide the over-limit values of the nitrogen oxides during the emission testing process. this affair is called "dieselgate". it is a well-known fact that the actual emission limits are very hard and there is arising a serious problem for automobile factories to meet the demanding emission requirements. the emission standard euro is an obligatory standard, which is valid wit ... | 2018 | 29929253 |
| amalgam alternatives: cost-effectiveness and value of information analysis. | we aimed to assess the cost-effectiveness of amalgam alternatives-namely, incrementally placed composites (icomp), composites placed in bulk (bcomp), and glass ionomer cements (gic). in a sensitivity analysis, we also included composite inlays (compi) and incrementally placed bulk-fills (ibcomp). moreover, the value of information (voi) regarding the effectiveness of all strategies was determined. a mixed public-private-payer perspective in the context of germany was adopted. bayesian network me ... | 2018 | 29928832 |
| improvement of hepatic and extrahepatic complications from chronic hepatitis c after antiviral treatment: a retrospective analysis of german sickness fund data. | german data regarding the economic burden of chronic hepatitis c (chc) and potential benefits of chc treatment are limited. to address this issue, we evaluated the role of treatment in mitigating the economic burden of hepatic and extrahepatic complications (ehcs) from chc virus infection in germany. | 2018 | 29923034 |
| clinical and economic burden of hepatic and extrahepatic complications from chronic hepatitis c: a retrospective analysis of german sickness fund data. | german data regarding the burden of complications from chronic hepatitis c (chc) virus infection are limited. to address this issue, this study evaluates the clinical and economic burden of hepatic and extrahepatic complications (ehcs) associated with chc in germany. | 2018 | 29923033 |
| restoring root-canal treated molars: cost-effectiveness-analysis of direct versus indirect restorations. | root-canal treated molars can be directly restored, usually using resin-based-composite restorations (rbcs), or indirectly restored using full or partial crowns (fcs/pcs). both the initial treatment costs and the risks of restorative and endodontic complications differ between rbcs and fcs/pcs. we aimed to assess the cost-effectiveness of rbcs versus fcs/pcs for restoring root-canal treated molars. | 2018 | 30006116 |
| clinical and economic impact of the taurolidine lock on home parenteral nutrition. | catheter-related bloodstream infections (crbsi) are one of the most serious concerns in patients on home parenteral nutrition (hpn) which involve high morbidity and cost for the healthcare system. in the last years, taurolidine lock has proven to be beneficial in the prevention of crbsi; however, the evidence of its efficiency is limited. | 2018 | 30070861 |
| quality of life and cost study of rheumatoid arthritis therapy with biological medicines. | biological medicines are considered as a cornerstone in the therapy of rheumatoid arthritis (ra). they change the course of the disease and improve the quality of life of patients. to this date there has been no study comparing the quality of life of and cost of ra therapy in bulgaria. this fact is what provoked our interest toward this research. the aim of this study is to analyse the cost and quality of life of patients with ra threated with biological medicines in bulgaria. this is an observa ... | 2018 | 30072903 |
| budget impact analysis of the use of extended half-life recombinant factor viii (efmoroctocog alfa) for the treatment of congenital haemophilia a: the italian national health system perspective. | congenital haemophilia a (ha) is a rare, inherited, life-long bleeding disorder characterised by prolonged or spontaneous bleeding due to the lack of clotting factor viii (fviii) in the body. treatment for ha involves fviii replacement therapy and poses great economic burden to national health systems and to society. availability of novel products as extended half-life clotting factor products might change treatment approches and their economic evaluation is essential for an informed treatment c ... | 2018 | 30071878 |
| addendum for euro surveill. 2018;23(5). | 2018 | 30064548 | |
| authors' correction for euro surveill. 2018;23(29). | 2018 | 30064547 | |
| authors' correction for euro surveill. 2018;23(5). | 2018 | 30064546 | |
| authors' correction for euro surveill. 2018;23(29). | 2018 | 30064545 | |
| [analysis of claims for wrong-site surgery (1986-2017)]. | wrong site surgery (wss) is a potentially preventable adverse event in healthcare. | 2018 | 30063039 |
| management of municipal solid waste in croatia: analysis of current practices with performance benchmarking against other european union member states. | the european commission has adopted a very ambitious circular economy package and has consequently revised many legislative proposals on waste. the new targets include achieving a recycling rate of 65% by 2030 and imposing a cap on landfilled waste to no more than 10% (as a percentage of weight). using available european and national databases on municipal solid waste indicators, we have analysed municipal solid waste production trends for croatia and have benchmarked the indicators against othe ... | 2018 | 30058472 |
| simultaneous determination of mono-, di-, oligo- and polysaccharides via planar chromatography in 4 different prebiotic foods and 60 naturally degraded inulin samples. | oligo- and polysaccharides, especially fructooligosaccharides and inulin, are increasingly used as food ingredients. they are reported to stimulate the growth of bifidobacteria and are therefore used as prebiotics. as mono-, di-, oligo- and polysaccharides can together be present in food, an hptlc method was developed for analyzing all in a single development. this method was used for both, effective food screening and quantification on the same plate. after a minimal sample preparation (aqueous ... | 2018 | 30055914 |
| sacubitril/valsartan (lcz696): a novel treatment for heart failure and its estimated cost effectiveness, budget impact, and disease burden reduction in germany. | heart failure affects over 1 million people in germany and contributes to morbidity, mortality, and high healthcare costs. a recent large randomized controlled trial compared the novel compound sacubitril/valsartan (lcz696) with the angiotensin-converting enzyme (ace) inhibitor enalapril and found a 16% reduction in mortality hazard. in germany, sacubitril/valsartan was launched at the beginning of 2016. | 2018 | 30054868 |
| modeling cold soak evaporative vapor emissions from gasoline-powered automobiles using a newly developed method. | volatile organic compounds (vocs) evaporate and vent from a vehicle's fuel tank to its evaporative control system when the vehicle is both driven and parked. vocs making it past the control system are emissions. driving and parking activity, fuel volatility, and temperature strongly affect vapor generation and the effectiveness of control technologies, and the wide variability in these factors and the sensitivity of emissions to these factors make it difficult to estimate evaporative emissions a ... | 2018 | 30047843 |
| cost effectiveness of intra-articular hyaluronic acid and disease-modifying drugs in knee osteoarthritis. | the place of disease-modifying osteoarthritis drugs (dmoads) and intra-articular hyaluronic acid (iaha) in the therapeutic arsenal for knee osteoarthritis (oa) remains uncertain. indeed, these treatments have demonstrated symptomatic efficacy but no efficacy for disease modification. | 2018 | 30047014 |
| erratum for euro surveill. 2018;23(28). | 2018 | 30043724 | |
| value of schizophrenia treatment ii: decision modelling for developing early detection and early intervention services in the czech republic. | positive findings on early detection and early intervention services have been consistently reported from many different countries. the aim of this study, conducted within the european brain council project "the value of treatment", was to estimate costs and the potential cost- savings associated with adopting these services within the context of the czech mental health care reform. | 2018 | 30036774 |
| economic evaluation of a population strategy for the treatment of chronic hepatitis c with direct-acting antivirals. | the high initial cost of antivirals against hepatitis c prompted development of the "strategic plan for tackling chronic hepatitis c in the spanish national health system". the objective of this study was the economic evaluation of the first two years of its application in navarre, spain. the change in the natural history of hepatitis c produced by the sustained virological response (svr) was compared to an alternative without treatment and modeled with patient-level data. by means of a discrete ... | 2018 | 30032627 |
| [effect of education and tailored exercise therapy on knee osteoarthritis patients]. | objective: to evaluate the effect of patient education and tailored exercise in the knee osteoarthritis (oa) patients. methods: one hundred and eighty-five patients with knee oa were enrolled in this ongoing prospective cohort study at arthritis clinic and research center, peking university people's hospital since may, 2016.the treatment consisted of two one-hour sessions of patient education and six weeks of supervised, in-group, tailored exercise.the contents of the patient education were evid ... | 2018 | 30032516 |
| diesel engine emission analysis using fuel from diverse emulsification methods. | the focus of this work is to investigate the emission characteristics of a stationary diesel engine while utilizing an emulsion fuel from a novel preparation process. the emulsion preparation was performed in real time without using any surfactant. instead of mechanically breaking the water down into droplets, the water is delivered thermally, by changing its phase from gas to liquid. steam is used in this proposed process, where it will be converted into suspended water droplets once it meets c ... | 2018 | 30030755 |
| the health and economic outcomes of early egg introduction strategies. | studies suggest early egg introduction (eei) in the first year of life is associated with reduced risk of developing egg allergy. no us recommendations exist regarding optimally implementing eei. | 2018 | 30028905 |
| selective vs stepwise removal of deep carious lesions in primary molars: 12-months results of a randomized controlled pilot trial. | for deep carious lesions, selective or stepwise carious tissue removal (se, sw) seem advantageous compared with non-selective removal. for primary molars, there is insufficient evidence comparing se against sw. this randomized pilot trial compared se and sw over 12 months. | 2018 | 30025748 |
| estimation of bus emission models for different fuel types of buses under real conditions. | urban buses are heavy vehicles that move frequently throughout the day, and most of them are propelled by heavy-duty diesel engines. for these reasons, they have energy and environmental impacts that should not be ignored. consequently, the primary objectives of this study were to compare the changes in bus speed, acceleration, and emissions between bus stops, intersections, and road sections by applying statistical methods; and to develop a vehicle specific power (vsp)-based artificial neural n ... | 2018 | 30021329 |
| reference intervals for serum 1,5-anhydroglucitol in children, adolescents, adults, and pregnant women. | 1,5-anhydroglucitol (1,5-ag) is a validated marker of short-term glycemic control. we determined the reference intervals of 1,5-ag in different age groups and during pregnancy. | 2018 | 30017617 |
| antihypertensive drugs in croatia: what changes the drug usage patterns? | possible factors that could influence changes in patterns of prescribing antihypertensives could be identified by monitoring national trends in hypertension treatment. the choice of pharmacologic treatment in people with hypertension has important therapeutic and financial implications, due to the fact that the financial costs associated with hypertension continue to increase. the aims of our study were to identify and analyze changes in the usage of antihypertensive drugs in croatia from 2000 t ... | 2018 | 30017168 |
| cost-effectiveness of sex-neutral hpv-vaccination in sweden, accounting for herd-immunity and sexual behaviour. | the aim was to assess cost-effectiveness of expanding the swedish hpv-vaccination program to include preadolescent boys, by comparing health-effects and costs of hpv-related disease, with a sex-neutral vaccination program versus only vaccinating girls. | 2018 | 30017146 |