Publications

isolation of yersinia enterocolitica from surface and well waters in ontario.	yersinia enterocolitica was isolated from forty-three surface- and well-water samples and one municipal supply. in many cases these samples were negative for coliform bacteria. after incubation of membrane filters on m-endo agar les at 35 degrees c for total coliform analysis, filters were held an additional 24 h at room temperature. this method was more productive for isolation of waterborne types of y. enterocolitica than was cold enrichment in buffer alone or in combination with modified rapp ...	1978	709433
gonorrhea in homosexual men.	extragenital gonorrhea was seen in 65% of 54 cases of gonorrhea in 43 homosexual men attending a venereal diseases clinic between 1974 and 1977; in 21 cases the infection was extragenital only. this type of gonorrhea was often asymptomatic and was associated with a high rate of failure of initial treatment in 6 of the 50 cases in which the patient returned for follow-up assessment, and in 5 of the 6 the persistent infection was extragenital. syphillis was seen concomitantly or had previously occ ...	1978	709473
report of survey of courses in medical terminology, human biology, health and disease presently required or available in programs in health or hospital administration.		1978	10318396
human tick infestations in ontario: findings at the toronto public health laboratory, 1967-1977.		1977	603862
the prevalence and epidemiology of toxoplasmosis in ontario.	the results of testing 7060 human serum specimens obtained in the province of ontario, canada, were analysed for the presence of antibodies to toxoplasma gondii. of these samples 38% were serologically positive at a titre of 1/16 or greater. the age-specific rates climbed from 2.7% in infants between 6 months and 1 year of age, to about 50% in individuals aged 25 years or over. variations in prevalence were noted between different areas within the province and evidence is put forward to show tha ...	1977	265346
antimicrobial susceptibility of salmonella isolates from the broiler chicken industry in ontario.	antibacterial drug resistance among 219 salmonella isolates recovered during 1974 from poultry and poultry environments at the various production stages of broiler chickens in three integrated ontario companies are recorded. all isolates were susceptible to ampicillin, trimethroprim-sulfamethoxazole complex, furazolidone, cephaloridine and amoxicillin. a relative increase in resistance to tetracycline and streptomycin with an accompanying decrease in resistance to triple sulfa compound was recor ...	1977	318909
antimicrobial resistance and resistance plasmids in salmonella from ontario, canada.	collections of 589 human and 204 animal strains of salmonella isolated in ontario during the summer of1974 were examined for susceptibility to 12 antimicrobial agents. many isolates were found to be resistant to both chloramphenicol (12.4% of the human and 38.2% of the animal sample) and ampicillin. the chloramphenicol resistance almost always occurred in strains which were also resistant to ampicillin and was usually due to a self-transmissible plasmid with a resistance pattern of cmkmsmtc (chl ...	1977	332297
organochlorine residues in human adipose tissue and milk from ontario residents, 1969-- 1974.		1977	849578
crowding and human reproduction.	studies of crowding in lower animals repeatedly demonstrate that compressed living conditions depress the ability of the species to reproduce. in a sample of 470 urban toronto women we examined the effect of neighborhood and household crowding on the probability of a pregnancy and on the probability that any given product of the pregnancy will not survive until one year of age. crowding did not influence fertility nor fetal and infant survival within the range of crowding found in this sample. ...	1976	958631
marfan syndrome with coronary artery lesions in a north american indian.	marfan syndrome has not been well documented in north american indians. a 19-year old ojibwa man had evidence of this syndrome -- specifically, tall stature, long, thin extremities (particularly, fingers and toes), increased urinary excretion of hydroxyproline, aortic aneurysm, aortic regurgitation and pathologic evidence of aortic rupture and alastic tissue fragmentation. intimal hyperplasia was present in the extramural coronary arteries, while the intramural arteries, usually thought to be in ...	1976	974953
fatal human infection with mesocercariae of the trematode alaria americana.	a fatal human infection with mesocercafiae of alaria americana is described. several thousand mesocercariae were estimated to be present in the peritoneal cavity, bronchial aspirate, brain, heart, kidney, liver, lungs, lymph nodes, pancreas, retroperitoneal adipose tissue, spinal cord, spleen, and stomach. nine days from the onset of symptoms death resulted from asphyxiation due to extensive pulmonary hemorrhage probably caused by immun-mediated mechanisms. circumstances suggest the victim proba ...	1976	1008125
the ombudsman in mental health: lakeshore's experience.		1976	1027535
physician contributions to nonmedical science: davidson black, our peking man.		1976	793707
chromosome analysis on 930 consecutive newborn children using quinacrine fluorescent banding technique.	chromosome analysing using quinacrine fluorescence was performed on 930 consecutive newborn infants. the total incidence of major chromosome aberrations including numerical changes of the sex chromosomes, and structural changes of autosomes, was 0.54%. incidence of xyy (0.4%) and xxy (0.2%) were relatively higher as compared to other studies. about 0.75% of the newborn infants were found to have a variable bright fluorescent band located on the proximal area of the short arm (p11) rather than on ...	1976	60278
human aural myiasis: a case in ontario, canada, and a partial review.		1976	1255358
sociocultural variation in sick role behavioural expectations.		1976	1265488
inter vivos transplantation and the human tissue gift act, s.o. 1971 c. 83.		1976	11662668
alan brown, the man.		1975	1098761
autopsy data and their total evaluation.	the role of the autopsy is discussed in the study of the etiology of the current major causes of death (cardiovascular and neoplastic diseases) in developed countries. evidence is accumulating for the importance of environmental factors in the etiology of these diseases. the study of regional differences in occurrence is described as a method of identifying specific factors. maps are shown of mortality rates for all causes of death in ontario counties for males aged 65-74 and 95+ during 1964-68. ...	1975	1109383
comparative study of ddt and its derivatives in human blood samples in norfolk county and holland marsh, ontario.		1975	1131452
distribution of organochlorine pesticides in an agricultural environment, holland marsh, ontario--1970-72.	analaysis of organochlorine pesticides in soil, fish, and human blood samples from holland marsh, ontario, indicates that although total ddt is present in detectable amounts, it does not constitute a hazard to human health and longevity. among soils tested, residues were highest in surface samples. ddt levels in human blood samples were similar to those in u.s. and british studies.	1975	1181548
the human hemoglobin variants in canada.	this report summarizes the results of a search for abnormal hemoglobin variants by use of a filter paper electrophoresis technique on 228,300 blood samples obtained from various parts of four canadian provinces. abnormal variants were found in 438 samples and were of 27 different varieties, including six new ones. in addition, the characteristics of beta-thalassemia were found in 147 samples. the types of variant found, and their geographical and ethnic origin are presented.	1975	1201625
an immunoprecipitin study of the incidence of influenza a antibodies in animal sera in the ottawa area.	a survey of over 600 'normal' sera from 14 animal species by immunoprecipitin tests in cellulose acetate using viron antigens revealed a high incidence of precipitating activity against a broad range of influenza a virus strains, particularly a2hhong kong/1/68 and /pr8. however, serum treatments trypsin-heat-periodate, naio4, v. cholerae receptor-destroying enzyme (rde), or kaolin eliminated most precipitating activity, which suggests that it was due to "non-specific" inhibitors of influenze vir ...	1975	167931
personalized care assures patients' rights.		1975	238881
the strengths and weaknesses of university review committees to protect human rights.		1974	4844661
survey on the incidence of yersinia enterocolitica infection in canada.	data pertaining to 278 cultures of yersinia enterocolitica isolated in canada are summarized in this paper. of this amount, 256 were isolated from humans, whereas 22 were of nonhuman sources. the typing of these cultures is presented together with their geographical location. y. enterocolitica serotype o:3 biotype 4, phage type 9b, was practically the only serotype present in the province of quebec. this serotype o:3 was also predominant in ontario, followed by serotypes o:5,27 and o:6,30; other ...	1974	4472776
review of human renal transplantation at the toronto general hospital.		1973	4570266
listeria monocytogenes infections in canada.	between 1951 and january 1972 listeriosis was diagnosed bacteriologically in 101 canadian patients. this study adds 80 cases to the 21 reported from metropolitan toronto by sepp and roy in 1963. the laboratory centre for disease control, ottawa, collated epidemiological and clinical data. serotypes of listeria monocytogenes included 4b (53), 1 (15), 1b (6), 1a (2), 2 and 3. clinically, 54 patients had meningitis and 23 septicemia. the mortality rate was 30%.between 1954 and january 1972 listerio ...	1973	4198595
interference of influenza-specific iga antibodies present in throat washings with isolation of the virus.		1973	4201894
at sunnybrook medical centre: the human side of rehabilitation.		1973	4781704
bovine tuberculosis in humans in ontario. the epidemiologic features of 31 active cases occurring between 1964 and 1970.		1972	4627829
a new subtype of type a influenzavirus isolated from turkeys.	a new subtype of avian influenzavirus a was isolated in january 1967 from an epizootic in a turkey hatchery in ontario, canada. the disease was fatal in 65 of 2 500 hens involved. virus was isolated from lung and trachea tissue of three dead turkeys. sera from convalescent birds contained antibody against the viruses isolated from the outbreak but not against other known type a avian influenzaviruses, newcastle disease virus, myxovirus yucaipa, or mycoplasma gallisepticum.the strain designated a ...	1972	4541004
a possible new enterovirus serotype isolated in ontario.		1971	4109494
psittacosis in hamilton: a case report and epidemiological study.	a case report of a patient severely ill with psittacosis is presented, together with an epidemiological study of his fellow workers. this study illustrates the contagiousness of the disease and indicates that it is probably more prevalent than clinical experience suggests. only three of the 83 persons studied who were exposed became ill enough to seek medical attention. it is important that both the physician and the public be made aware of this disease so that definitive treatment can be instit ...	1970	5410417
strontium-90 and infant mortality in canada.		1970	5474939
vitamin a reserves of canadians.	-a survey of vitamin a and carotene stores of canadians at five major centres across canada was completed. vitamin a and carotene analyses were performed on approximately 100 human liver specimens obtained at necropsy from each location.age influenced liver vitamin a stores. children between 1 and 10 years of age had the highest vitamin a stores while a trend toward lower liver stores occurred between 20 and 40 years of age. females had higher liver carotene stores than males but there was no su ...	1969	5364272
rabies today--man and animals.		1969	5812488
chromosome aberrations in 2159 consecutive newborn babies.		1969	4238063
central nervous system involvement associated with unclassified echovirus types.		1968	5645182
occurrence of echovirus 33 infections in ontario.		1968	5690127
myxovirus dissemination by air.	myxoviruses including 150 strains of parainfluenza 1, 15 of parainfluenza 3 and five of influenza b virus were isolated from nasopharyngeal secretions obtained from 300 children less than 3 years of age who developed acute laryngotracheobronchitis during the preceding 48 hours. the patients were examined between october 1966 and january 1967, the peak monthly rate of virus isolation (67%) occurring during january. parainfluenza 1 virus was isolated from air obtained in the vicinity of one of 30 ...	1967	4290621
[a laboratory of human relations].		1967	5182984
powassan virus: persistence of virus activity during 1966.	powassan virus isolations were achieved from three of 60 pools of ixodes cookei ticks removed from 286 groundhogs (marmota monax) which were collected some 200 miles north of toronto between may 5 and september 5, 1966. virus yields per pool of one to 11 ticks ranged from 10(2.5) to 10(6.0) tcd(50) for primary swine kidney tissue cultures, and positive pools were collected on june 24, july 15 and august 10. powassan neutralizing antibodies were detected by mouse inoculation tests in 143 of 362 a ...	1967	6019677
"skid row" syndrome: a medical profile of the chronic drunkenness offender.	from skid row, 227 chronic "drunks", inmates of the toronto jail, were studied to determine the physical features and illnesses of this group. complete physical examinations, liver function tests, routine hematology, urinalysis, chest radiographs were carried out and previous hospital records were obtained for each man. the data were analyzed by ibm computer and reported in terms of body systems. items that occurred in sufficient frequency were separated out and listed to compile a "skid row" sy ...	1966	5947765
viral infections of toronto children during 1965: ii. measles encephalitis and other complications.	among 16 cases of measles encephalitis observed in toronto during 1964 and 1965, including six who were stuporous or comatose on admission and five who presented with convulsions, measles virus was isolated from csf of one patient, rising titres of measles antihemagglutinin were detected in another patient, and 14 showed high antibody titres in sera collected as early as two to five days after onset of the measles rash. increasing levels of measles antibody were detected in paired sera from thre ...	1966	4952371
[a laboratory of human relations at honey harbour].		1966	5177426
human trichinosis: report of four cases, with emphasis on central nervous system involvement, and a survey of 500 consecutive autopsies at the ottawa civic hospital.	in 1963, acute trichinosis was recognized in four patients at the ottawa civic hospital. one presented with cavernous sinus thrombosis and sixth nerve palsy. a second had a severe systemic infection with myocarditis; the signs of myocarditis appeared in the third week. electrocardiographic abnormalities included t-wave flattening, prolongation of pr interval and qrs complex, and non-specific changes in 25%. central nervous system involvement occurred in the second week with general symptoms (hea ...	1966	4288427
enteroviral syndromes in toronto, 1964.	virological or serological investigations of 72 children in toronto and environs, who were hospitalized between january and october 1964 with a variety of syndromes, revealed evidence of enteroviral infection in 29 subjects. coxsackie b2 was the dominant enterovirus, being isolated from feces and/or cerebrospinal fluid (csf) of three children with aseptic meningitis, three with pleurodynia, one with myalgia and one with pericarditis; four additional patients showed rising antibody titres to this ...	1965	14269435
an outbreak of aseptic meningitis due to echo 25 virus.	in a widespread outbreak of aseptic meningitis during the summer and early fall of 1961 in ontario, echo type 25 virus was found to be the predominant virus type isolated from affected patients. recovery of echo 25 virus in several cases from the csf of patients strongly suggests an etiological relationship between this virus type and the illness. the causative role of the virus was confirmed by demonstration of significant immunological response in patients found to be infected with the virus. ...	1964	14156829
enteroviral and mumps meningitis in toronto, 1963.	virological investigations of 115 children with the aseptic meningitis syndrome during 1963 resulted in the isolation of enteroviruses from cerebrospinal fluid (csf) and/or feces of 21 of 48 children who had no association with mumps. for the third successive year, echo 9 was the dominant enterovirus in cases of aseptic meningitis in toronto children, but no rashes were associated with echo 9 meningitis during 1963, in contradistinction to previous years. mumps virus was isolated from csf of 25 ...	1964	14158544
q fever in canada.	a canada-wide survey of q fever was begun in 1958 in co-operation with public health and veterinary laboratories to determine the presence and prevalence of the disease so that medical practitioners might be alerted to the potential dangers existing. serologic evidence obtained indicated that the q fever rickettsia now exists in cattle in all provinces of canada except new brunswick, nova scotia, and prince edward island. isolations of the rickettsia were obtained from bovine milk samples from o ...	1964	14175873
epidemic type a influenza in southwestern ontario in 1963.	from february to april 1963 epidemic type a influenza occurred in southwestern ontario. eighty cases were diagnosed virologically, 24 of them by isolation of virus. the epidemic strain of virus proved unusually difficult to adapt to growth in embryonated eggs, and it had low avidity for antisera. antigenically it differed from a2 strains of earlier years and belonged to the subgroup of a2 influenza viruses characterized by the a2/japan/170/62 strain. antisera to a2 strains of earlier years neutr ...	1964	14176060
red cell glucose-6-phosphate dehydrogenase deficiency--a newly recognized cause of neonatal jaundice and kernicterus in canada.	seven male newborns of chinese, greek and italian origin presented with severe hemolytic jaundice due to red cell glucose-6-phosphate dehydrogenase (g-6-pd) deficiency. in five, the hemolysis was precipitated by inhalation of mothball vapours in the home. kernicterus was evident upon admission in six infants and was fatal in four of these.g-6-pd deficiency should be suspected as a cause of jaundice in all full-term male infants of these ethnic groups. the diagnosis can be confirmed in any hospit ...	1964	14226101
sporadic occurrence of echo virus types 27 and 31 associated with aseptic meningitis in ontario.	the sporadic occurrence of echo virus types 27 and 31 in association with aseptic meningitis during the enterovirus seasons in ontario in 1959 to 1962 is reported.the etiological significance of both of these isolates was verified by demonstration of type-specific serological response in meningitis patients. echo 27, which up to now has not been encountered in association with human illness, could be added to the list of viral agents capable of causing aseptic meningitis. isolation of echo 31 fr ...	1964	14226105
ionizing radiation as an industrial health problem.	ionizing radiation, first as x-rays, later in natural form, was discovered in europe in the late 1890's. immediate practical uses were found for these discoveries, particularly in medicine. unfortunately, because of the crude early equipment and ignorance of the harmful effects of radiation, many people were injured, some fatally. because of these experiences, committees and regulatory bodies were set up to study the problem. these have built up an impressive fund of knowledge useful in radiatio ...	1964	14105012
isolation of enteric viruses in ontario during 1960-1962.	during the past three years at the central laboratory, ontario department of health, 681 isolations were made in tissue culture from 6822 specimens submitted for virus studies by physicians and hospitals from all over ontario. nearly 74% of the isolates were enteroviruses, approximately 5% adenoviruses and about 1% reoviruses. the remaining 20% are still to be identified.although the bulk of isolations was made during the same three-month period (august, september and october) of each year, the ...	1963	14052975