Publications

lovastatin and simvastatin--inhibitors of hmg coa reductase and cholesterol biosynthesis.	the microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme a (hmg coa) reductase is a key rate-controlling step early in the cholesterol biosynthetic pathway that catalyzes the conversion of hmg coa to mevalonic acid. since this enzyme plays a significant role in regulating cholesterol synthesis, it is a rational target for pharmacologic intervention. the first potent, specific inhibitor of hmg coa was mevastatin (compactin, ml-236b), which was discovered in 1976 by endo et al. [j antibiot 1976:2 ...	1990	2073667
clinical and experimental mycotic keratitis caused by aspergillus terreus and the effect of subconjunctival oxiconazole treatment in the animal model.	aspergillus terreus was isolated from a case of keratomycosis. the patient, a 50 year old, female presented with a large corneal ulcer with hypopyon. the direct microscopic examination of the scrapings revealed hyaline, thin, septate and branched hyphae. in vitro some antimycotics (amphotericin b, 5-fluorocytosine, oxiconazole, amorolfine and ketoconazole) were tested against a. terreus by agar dilution method. ketoconazole with mic of 3 micrograms/ml after 7 days of incubation was most effectiv ...	1990	2089254
aspergillus terreus myocarditis: report of a case and review of the literature.	aspergillus terreus is an uncommon cause of myocarditis, with only six reported cases in the world literature. this report describes a case of severe disseminated aspergillus terreus infection with extensive involvement of the heart in an immunosuppressed patient after aortic valve replacement surgery. pathologic findings are similar to those found in aspergillus fumigatus myocarditis. all six previously reported cases of a. terreus carditis occurred in postoperative cardiac surgery or immunocom ...	1990	2095835
[biological properties of an alcoholic extract of aspergillus terreus].	the following effects of aspergillus terreus alcoholic extract are investigated: antiblastic and antiviral effect, and the ability of modification of interferon production and lymphocyte blastic transformation. in particular the extract showed more evident antiproliferative effect on transformed or ebv immortalised cells and lower effect on normal cells. moreover doses from 12.5 +/- micrograms/ml depressed significatively the in vitro interferon production and lymphocyte blastic transformation i ...	1990	2102121
production of l-dopa by aspergillus terreus.	production of l-dopa by the activity of tyrosinase from a strain of aspergillus terreus 104 was investigated. effects of substrate (l-tyrosine) concentrations, its mode of feeding to the assay mixture and also the effects of l-ascorbic acid and other antioxidants on the production rate of l-dopa were studied. the parameters for optimal production of l-dopa with a maximum conversion of 85% of 0.1% l-tyrosine were determined.	1990	2126517
pulmonary aspergillosis due to aspergillus terreus combined with staphylococcal pneumonia and hepatic candidiasis.	a female patient with systemic lupus erythematosus (sle) developed pulmonary aspergillosis with staphylococcal pneumonia and hepatic candidiasis. aspergillus terreus, which is a rare causative organism of pulmonary aspergillosis, was identified from a pulmonary lesion by culture. the aleurioconidium production, a characteristic of the genus aspergillus sect. terrei, was demonstrated on short and irregular hyphal features in tissue sections. this report is the first of a combined case of pulmonar ...	1990	2233979
characterization of glucoamylase from aspergillus terreus 4.	a strain of aspergillus terreus 4 was found to show extracellular amylolytic activity and the amylase was identified as glucoamylase enzyme. the optimum temperature for the enzyme activity was 60% and it was stable at this temperature for 1 h. the enzyme was optimally active at ph 5.0 and stable between ph 3.0-8.0. km values of glucoamylase for soluble starch, amylose and amylopectin were 5.9 mg/ml, 4.8 mg/ml and 2.6 mg/ml respectively.	1990	1691122
crude oil and hydrocarbon-degrading strains of rhodococcus rhodochrous isolated from soil and marine environments in kuwait.	soil and marine samples collected from different localities in kuwait were screened for microorganisms capable of oil degradation. both fungi and bacteria were isolated. the fungal flora consisted of aspergillus terreus, a. sulphureus, mucor globosus, fusarium sp. and penicillum citrinum. mucor globosus was the most active oil degrading fungus isolated. bacterial isolates included bacillus spp. enterobacteriaceae, pseudomonas spp., nocardia spp., streptomyces spp.,and rhodococcus spp. among thes ...	1990	15092275
bioconversion of aflatoxin g1 to aflatoxin b 3 by selected fungi.	aflatoxin g1 (afg1) was transformed into aflatoxin b3 (afb3) by the fungirhodotorula sp,sporobolomyces sp,rhizopus oryzae nrrl395,pythium ultimum, aspergillus terreus, a clavatus and penicillium frequentans grown in a medium containing afg1, difco potato dextrose broth, yeast extract, and peptone both in liquid shaken cultures and in solid static cultures at 25°c in the dark. a maximum rate of transformation of 10 % was obtained after 2 to 3 weeks of incubation. the transformation was correlated ...	1990	23605445
origin of monacolin l from aspergillus terreus cultures.	in freshly harvested aspergillus terreus cultures grown for the production of lovastatin (formerly called mevinolin), no monacolin l could be detected. however, during the isolation of lovastatin, significant quantities of monacolin l appeared. it has been discovered that a new metabolite structurally related to the members of the monacolin series is present. this metabolite is unstable and under mildly acidic conditions and elevated temperature, it converts to monacolin l. the subject metabolit ...	1989	2921224
incorporation of tellurium into amino acids and proteins in a tellurium-tolerant fungi.	aspergillus fumigatus, aspergillus terreus, and penicillium chrysogenum, a tellurium tolerant fungi, are able to grow on sulfur free medium amended with 0.2% (w/v) tellurite. tellurium was incorporated into several types of low and high molecular weight proteins. the newly detected telluro-proteins contained an extraordinary high level of tellurium, as well as telluro-cysteine, telluro-cystine, telluro-methionine, and serine.	1989	2484755
aspergillus ball thrombus occluding a homograft conduit.	almost total occlusion of an aortic homograft conduit by a ball of aspergillus terreus was found postmortem in a 6-month-old infant following repair of a type i truncus arteriosus. signs of pulmonary hypertensive crisis, fever, anaemia, and thrombocytopenia were present. however, blood cultures were persistently negative. a 2-d echocardiogram failed to demonstrate any vegetation. the clinical, pathological, and postmortem findings are described and difficulties in the diagnosis of aspergillus in ...	1989	2624793
disseminated aspergillus terreus infection in immunocompromised hosts.	aspergillus terreus is ubiquitous in the environment but has rarely been found to be pathogenic. when recovered from clinical specimens, it is commonly considered a saprophyte. we report two cases of fatal disseminated a. terreus infection. the first patient was receiving corticosteroid therapy for immune thrombocytopenia when the condition developed, and the second patient was receiving immunosuppressive therapy after bone marrow transplantation for myelodysplasia. we also describe the frequenc ...	1989	2671518
[features of integration of recombinant cosmids, containing aspergillus terreus dna, in the saccharomyces cerevisiae genome].	a genome clonotheque of 25-40 kb sau3a fragments of aspergillus terreus dna was constructed in the episomal cosmid vector pes33 containing the arg4 gene of yeast. 23 independently originated stable arg+ transformants were selected after transformation of the cir0 yeast strain esh-o with pooled cosmid molecules. both genetic and southern analysis showed that 39% of these stable transformants occurred due to recombination between dna sequences from a. terreus and saccharomyces cerevisiae chromosom ...	1989	2684748
riboflavin formation by mould fungi cultivated on hydrocarbon-containing media.	the potentiality of some mould fungi, isolated from petroleum sludge to produce riboflavin when grown on hydrocarbon-containing media was tested. aspergillus terreus was found to be distinguished by its capacity to produce riboflavin when cultivated on the different culture media tested. it was able to grow more luxuriantly and produce good riboflavin output on solar-containing medium. a solar concentration of 5% v/v favoured high riboflavin productivity. the maximal vitamin b2 yields were achie ...	1989	2739581
cytological effects of fungal metabolites produced by fungi isolated from egyptian poultry feedstuffs.	the cytogenetic effects of fungal metabolites produced by 113 strains belonging to 36 fungal species and isolated form 5 substrates of commercial poultry feedstuffs were tested for their effect on the growing root meristems of allium cepa. the fungal metabolites of paecilomyces canescens, aspergillus fumigatus, syncephalastrum racemosum, aspergillus terreus and mucor hiemalis strongly suppressed cell division. metabolites from other strains had less effect on cell division but permitted the appe ...	1989	2746472
colonization of a squamous cell carcinoma in the bovine horn core by aspergillus terreus.	aspergillus terreus, an opportunistic pathogen, was found to be associated with cancerous tissue of the horn core in a weak and old debilitated cow. the organism was isolated in pure and luxurient growth from a surgically operated specimen of the horn core, and was also demonstrated in the fresh mounts and pas stained sections of the infected tissues. the isolate showed resistance to nystatin (100 micrograms) when tested by paper disk diffusion technique. this appears to be the first report on t ...	1989	2755465
production and characterization of a murine monoclonal antibody to aspergillus fumigatus antigen having igg- and ige-binding activity.	by employing hybridoma technology, a monoclonal antibody against aspergillus fumigatus was produced. this antibody, isotyped as igm k, reacted with 12 of 16 antigens extracted from 9 different a. fumigatus strains. this antibody also reacted with all 3 aspergillus flavus antigens studied, but not with aspergillus niger, aspergillus terreus, penicillium notatum or candida albicans antigens. western blot analysis indicated that this antibody reacted with two concanavalin a (con-a) binding bands of ...	1988	3045013
cosmids carrying aspergillus terreus dna can integrate into saccharomyces cerevisiae chromosome xii via recombination between yeast and foreign dnas.	a genome clonotheque consisting of 25- to 40-kb sau3ai fragments of aspergillus terreus dna was constructed in the episomal cosmid vector pes33 containing the yeast arg4 gene. from the 475 transformants of cir0 yeast strain esh-0, 23 stable arg+ transformants were independently selected. genetic and southern analysis of these stable transformants showed that 39% arose as a result of recombination between cloned a. terreus dna sequences and yeast chromosome xii. the recombination events most like ...	1988	3058328
[characteristics of the integration of recombinant cosmids containing dna of aspergillus terreus into genome of saccharomyces cerevisiae].		1988	3069411
binding of fibrinogen to the pathogenic aspergillus species.	the binding of human fibrinogen to the pathogenic aspergilli was investigated in vitro by different procedures using either fibrinogen in solution or fixed, insolubilized fibrinogen. binding of fibrinogen was detected at the surface of hyphae and conidia by an immunofluorescence assay. ultrastructural localization of the binding sites was visualized with fibrinogen-sensitized gold particles. the labelling was restricted to the outer cell wall layer of the 'smooth' walled conidia. quantitative an ...	1988	3073204
humoral immunity in disseminated aspergillus terreus infection in the dog.	aspects of humoral immunity were studied in 17 dogs with disseminated aspergillosis (16 cases aspergillus terreus, 1 case aspergillus flavipes). all dogs had markedly raised serum igg levels by single radial immunodiffusion (range 1500-6000 mg dl-1). despite this, serum antibody to a. terreus was demonstrated in only 7/16 cases by agar gel diffusion, 9/16 cases by counter immunoelectrophoresis, 10/16 by elisa and 11/16 by an indirect immunofluorescence assay. serum antibody was also detected in ...	1988	3131949
[aspergillus terreus as a cause of inflammation of the maxillary sinus].		1988	3167990
aspergillus terreus as a cause of invasive pulmonary aspergillosis.	a 70-year-old woman with nodular, poorly differentiated lymphocytic lymphoma is the third reported patient with invasive pulmonary aspergillosis caused by aspergillus terreus. this case differs from the two previously reported in that neither neutropenia nor broad spectrum antibiotics preceded the infection. a terreus should not be dismissed as a laboratory contaminant in pulmonary specimens, especially those from immunosuppressed patients.	1988	3168592
a novel anthraquinone ring cleavage enzyme from aspergillus terreus.	an enzyme activity which catalyzes the ring cleavage of the anthraquinone questin to form benzophenone desmethylsulochrin was found in the cell-free extract of aspergillus terreus, a (+)-geodin producer. the product was identified as desmethylsulochrin by high-resolution mass spectroscopy and chemical carrier dilution analysis. the enzyme showed an absolute requirement of nadph and molecular oxygen. therefore, the enzyme, named questin oxygenase, was considered to be classified as a monooxygenas ...	1988	3182756
aspergillus terreus infection in a patient with chronic lymphocytic leukaemia and polycythaemia rubra vera.		1988	3362085
selenoprotein in aspergillus terreus.	aspergillus terreus, a moderately selenium-tolerant fungus, metabolized se-selenite into several protein seleno-amino acids: selenomethionine and selenocysteine, as well as, nonprotein seleno-amino acids, selenocystathionine, and y-glutamyl selenomethyl selenocysteine. the results indicate the failure of the fungus to discriminate between sulphur and selenium. selenium was also incorporated into several proteins of different molecular weights, mostly of low molecular weight proteins. labeled stu ...	1988	2484562
biosynthesis of territrems by aspergillus terreus.	different radioactive precursors were added to 8-day potato-dextrose liquid cultures of aspergillus terreus 23-1. territrems were isolated from chloroform extracts of the cultures at day 14 and purified by thin-layer chromatography and high-pressure liquid chromatography. the territrem b obtained was treated with alkaline hydrogen peroxide, and 3, 4, 5-trimethoxy benzoic acid was isolated from an ethyl acetate extract of the reaction mixture and purified by thin-layer chromatography and high-pre ...	1988	16347569
purification and properties of dihydrogeodin oxidase from aspergillus terreus.	the last step of (+)-geodin biosynthesis is a phenol oxidative coupling, which is one of the most important reactions in biosynthesis of natural products. the enzyme named dihydrogeodin oxidase catalyzes the regio- and stereospecific phenol oxidative coupling reaction to form (+)-geodin from dihydrogeodin. the enzyme was purified from the cell-free extract of aspergillus terreus, a (+)-geodin producer, by ammonium sulfate fractionation, acid treatment, and column chromatographies on deae-cellulo ...	1987	3032923
biosynthesis of mevinolin, a hypocholesterolemic fungal metabolite, in aspergillus terreus.	mevinolin and compactin are fungal metabolites which inhibit cholesterol biosynthesis in mammalian systems. biogenetically, mevinolin is formed from polyketide chains, one 18-carbon and one 4-carbon, derived from acetate in normal head to tail fashion. the remaining two carbons in mevinolin, namely c-2' and c-6 methyl groups, are transferred from s-adenosylmethionine. to distinguish the timing and sequence of these two methylation steps, [me-14c]- and [me-3h,14c]-l-methionine were fed to aspergi ...	1987	3423140
[endocarditis with unusual causative agents].	in the period 1947-1985, 601 patients with infective endocarditis were seen at the university hospital zurich and the kantonsspital lucerne. streptococci, enterococci and staphylococci were the predominant causative organisms in two-thirds of all cases. in more than 25% of the patients blood cultures remained negative. in 6 patients endocarditis was caused by very rare organisms, viz. coxiella burnetii (2 cases), hemophilus parainfluenzae, corynebacterium bovis (diphtheroids), brucella melitensi ...	1987	3324331
inhibitory effect of mutastein on the synthesis of artificial, dental plaque by streptococcus mutans.		1987	3570972
aspergillus terreus as a possible cause of mycetoma on the foot of a dog.		1987	3587279
a rapid enzymatic assay for total blood polyamines.	we have designed a rapid, reliable enzymatic assay for total blood polyamines, as based on the combination of substrate specificity of polyamine oxidase (pao) from aspergillus terreus and putrescine oxidase (puo) from micrococcus rubens. quinone dye, derived from hydrogen peroxide generated in the oxidation reaction, is measured spectrophotometrically at 555 nm, and total amounts of putrescine (put), cadaverine (cad), spermidine (spd), and spermine (spm) can be readily determined. the minimum de ...	1987	3652436
isolation of (-)-gamma-cadinene and aristolochene from aspergillus terreus.		1987	3680043
beta-glucosidases from cellulolytic fungi aspergillus terreus, geotrichum candidum, and trichoderma longibrachiatum as typical glycosidases.	by ethanol precipitation (v/v) and chromatography on sephadex sp, deae (or deae-cellulose), and g-200 beta-glucosidases (ec 3.2.1.21) from the culture filtrates of cellulolytic fungi aspergillus terreus, geotrichum candidum, and trichoderma longibrachiatum grown on the medium with cellulose containing materials were isolated. the enzymes were homogenous as shown by different techniques. the substrate specificities of the obtained enzymes were studied. beta-glucosidases had higher affinity for p- ...	1987	3111495
new fungal strains that produce a specific inhibitor of adhesive glucan synthesis by streptococcus mutans.		1987	2952628
biochemical studies on acetate non-utilizing mutants of aspergillus terreus irrl 16043.	the strain aspergillus terreus irrl 16043 can utilize glucose as well as acetate as a sole carbon source. thirty-nine mutants were isolated from the wild-type by treatment with a chemical mutagen, n-methyl-n'-nitro-n-nitrosoguanidine (mntg) which could not utilize acetate as a sole carbon source, and were designated as acetate non-utilizing (acu). by complementation and biochemical analyses they were divided into three functional groups, acu a, acu b and acu c lacking isocitrate lyase, malate sy ...	1987	2885725
chromatographic quantitation of territrems a, b, and c, tremorgenic mycotoxins from aspergillus terreus.	this paper describes assay procedures for territrems a, b, and c by thin layer chromatography (tlc)-fluorodensitometry and reverse phase high performance liquid chromatography (hplc).	1987	23604807
[caries-inhibitory effect of mutastein in animal experiments].		1986	2974614
terrecyclic acid a, a new antibiotic from aspergillus terreus. iv. absolute stereochemistry of terrecyclic acid a.		1986	3949627
aspergillus terreus causing invasive pulmonary aspergillosis with air-crescent sign.	aspergillus terreus is an uncommon cause of human disease. a patient with acute myelomonocytic leukemia is described who developed an invasive pulmonary infection with a terreus characterized by an air-crescent sign on chest roentgenogram. previous reports of a terreus infections and the pathogenesis and significance of an air-crescent sign in invasive pulmonary aspergillosis are reviewed.	1986	3458927
[antiproliferative effect of an extract of aspergillus terreus].	we have studied antiproliferative effect of aspergillus terreus extract on various cell lines: i-407 normal human cells, l-929 normal murine cells, k-562 erythroleukemic human cells, iad lymphoblastoid human cells and b 95-8 monkey lymphoblastoid cells. k-562 and lymphoblastoid cells showed higher sensitivity to the extract. moreover, "a cytostatic dose" of the extract on k-562 cells (12.5 micrograms/ml showed a reduction of 3h-thymidine (but not of 14c-uracil) incorporation, leading us to hypot ...	1986	3483336
in vitro activity of alpha, beta, gamma human interferons and aspergillus terreus mycotoxins on cell proliferation.	the in vitro effect of different doses of alpha, beta and gamma human interferons and their interaction on the proliferation rate of human erythroleukemic cell line (k-562) and other cell lines has been evaluated. the results show that the stronger activity is exerted by beta hif in comparison with alpha hif. the action is selective and species-specific. beta hif never elicited an "enhancing" effect on cell proliferation; on the contrary this phenomenon has been observed to occur with alpha and ...	1986	2437939
enzymatic saccharification of pretreated rice straw and biomass production.	a comparative study on the saccharification of pretreated rice straw was brought about by using cellulase enzyme produced by aspergillus terreus atcc 52430 and its mutant strain ungi-40. the effect of enzyme and substrate concentrations on the saccharification rate at 24 and 48 were studied. a syrup with 7% sugar concentration was obtained with a 10% substrate concentration for the mutant case, whereas a syrup with 6.8% sugar concentration was obtained with 3.5 times concentrated enzyme from the ...	1986	18553867
intensification of oak sawdust enzymatic hydrolysis by chemical or hydrothermal pretreatment.	the activities of cellulases and xylanase were determined in laboratory cultures of aspergillus terreus f-413 performed on natural and chemically or hydrothermally pretreated oak sawdust. the best stimulation effects were obtained in the cultures containing sawdust treated with dioxane, sodium hydroxide, or phosphoric acid. moreover, the sawdust pretreatment distinctly affected its enzymatic hydrolysis, especially when the preparation of hydrolase complex was isolated from the culture of a. terr ...	1986	18555354
evaluation of supercritical fluid extraction in the pharmaceutical industry.	various steroids precipitate from supercritical co(2) as very small particles but still retain their crystallinity. this suggests that scfe in this industry could be utilized as a size reduction method as an alternative to milling. the application of scfe as a separation technique is demonstrated by the simultaneous extraction and reaction of mevinolin, a metabolite of the fungus aspergillus terreus.	1986	20568193
mevinolinic acid biosynthesis by aspergillus terreus and its relationship to fatty acid biosynthesis.	mevinolinic acid, the open acid form of mevinolin, which is a metabolite of aspergillus terreus, has been shown to be a competitive inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme a reductase (alberts et al., proc. natl. acad. sci. u.s.a. 77:3957-3961, 1980). the biosynthesis of mevinolinic acid was studied by examining the incorporation of [1-14c]acetate and [methyl-14c]methionine into the molecule. these isotopes were rapidly incorporated into mevinolinic acid, with [1-14c]acetate ...	1985	3988710
isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem b' from aspergillus terreus.	we have isolated a metabolite of territrem, designated territrem b', from the chloroform extract of a rice culture of aspergillus terreus 23-1 by using the same isolation procedure as that for territrems a, b, and c. the present isolation procedure gave about 10 mg of territrem b' from 4 kg of rice culture per batch. analysis of the high-resolution mass spectrum showed that the molecular composition of territrem b' is c29h34o10 (found, 542.2167; required, 542.200). some results of physicochemica ...	1985	3994375
mycotic pneumonia and meningoencephalitis due to aspergillus terreus in a neonatal snow leopard (panthera uncia).		1985	4032629
abnormal form of aspergillus terreus isolated from mycotic abscesses.	a remarkable outer cell-wall thickening (up to 1.5 mum) was observed on septate hyphae obtained from pus collected from multiple abscesses of a 25-year-old female patient. ultrastructural examination of the hyphae showed a thick electron dense layer of microfibrillar material surrounding the electron transparent cell wall. the organism was able to grow only on hypertonic media upon initial isolation but on later subculture it grew on normal isotonic media. the thick microfibrillar material dimin ...	1985	4047126
the pathology of disseminated aspergillus terreus infection in dogs.	disseminated aspergillus terreus infection was diagnosed in ten previously healthy adult dogs--nine german shepherds and one dalmatian. the disease was characterized by the presence of multiple granulomas and infarcts in a wide range of organs. the kidney, spleen, and skeletal system were most commonly and severely affected. fungal hyphae were demonstrated in large numbers within granulomas and thrombi, and a. terreus was readily isolated by culture. this disseminated mycosis appears unique; in ...	1985	4082379
cellulolytic activity of moulds. iii. enzymatic hydrolysis of cellulose by cellulase preparation from aspergillus terreus f-413.	the strain aspergillus terreus f-413 was used to obtain cellulolytic enzymes; it was cultivated on cellucotton by the submerged method in a 101 fermenter. the crude enzymatic preparation obtained from the post-culture liquid, containing small amounts of other enzymes besides active cellulases, was used for hydrolysis of several kinds of cellulose. the highest saccharification percentage was obtained with cellucotton and filter paper, while the lowest with lignocellulosic materials such as straw ...	1984	6083705
cellulolytic activity of moulds. iv. evaluation of the utility of cellulosic wastes for biosynthesis of cellulases and xylanase by aspergillus terreus f-413.	the value of various cellulosic wastes for the synthesis of cellulolytic enzymes by the mould aspergillus terreus f-413 was determined in submerged culture. the best results were obtained by using beet pulp. the dynamics of their synthesis was observed during a 12-day culture on the medium most favourable for the synthesis of cellulases.	1984	6083706
studies on the biosynthesis of terrecyclic acid a, an antitumor antibiotic from aspergillus terreus.	the biosynthesis of terrecyclic acid a was investigated using 13c-labeled acetates and mevalonate. 13c nmr spectral analysis of isolated labeled terrecyclic acid demonstrated that the structure is assembled via an isoprene pathway.	1984	6511664
hypersensitivity pneumonitis concomitant with acute airway obstruction after exposure to hay dust.	the case of a non-atopic farmer who had developed severe respiratory as well as systemic symptoms upon exposure to hay dust during the past several years is presented. inhalation challenge by his own hay induced an unusual association of peripheral and central airway obstruction beginning immediately, and hardly susceptible to therapeutic control, as well as the typical hypersensitivity pneumonitis reaction several hours later. by means of double immunodiffusion it was possible to demonstrate se ...	1984	6522842
chemical structure of a new metabolite isolated from the mycelium of aspergillus terreus var. aureus.		1984	6529817
isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem c from aspergillus terreus.	territrem c, a new tremorgenic mycotoxin (c28h32o9; molecular weight, 512.20) was isolated from the chloroform extract of rice cultures of aspergillus terreus 23-1, which also produces territrems a and b. isolation, acute toxicity, and some physicochemical properties of territrem c are discussed in this paper. the spectral and chemical evidence indicated that the structural difference between territrem c and territrem b (c29h34o9) was in their phenyl moieties: a 4-hydroxy-3,5-dimethoxy phenyl gr ...	1984	6546485
growth and enzyme production by aspergillus terreus in holocellulose.	the growth of aspergillus terreus thom in holocellulose medium and the production of xylanase and cellulolytic enzymes were studied and compared with growth and enzyme production in xylan and cellulose powder media. hemicellulose and cellulose were utilized simultaneously by the fungus when grown in holocellulose medium. the growth was similar in the presence of xylan and cellulose powder, but xylan was consumed earlier than cellulose. cellulose powder, carboxymethylcellulase and xylanase activi ...	1984	6721328
terrecyclic acid a, a new antibiotic from aspergillus terreus. iii. 13c nmr spectrum of terrecyclic acid a.	assignment of the fifteen carbons of terrecyclic acid a, c15h20o3, a new sesquiterpene antibiotic, in the 13c nmr spectrum was performed by 13c-[1h] selective proton decoupling experiments, comparison with spectra of its derivatives and chemical shifts.	1984	6735922
in vivo pulmonary response to aspergillus terreus spores.	the fate of intratracheally instilled aspergillus terreus spores was followed in both rabbits and rats. phagocytosis of the spores by the pulmonary macrophage was rapid in that approx. 42% of the observed spores were associated with the macrophages immediately after instillation. direct penetration of the lung architecture by the spores was not observed but spores were seen in the alveolar interstitium at 3 hr after instillation and in the tracheobroncheal lymph nodes at 24 hr. granulomas formed ...	1983	6825418
allergic bronchopulmonary aspergillosis caused by aspergillus terreus.		1983	6830061
[fractionation of the cellulase complex of the fungus aspergillus terreus].	a procedure for isolating a complex of extracellular cellulases from the aspergillus terreus culture liquid using sp-sephadex c-50 has been developed. enzymatically and electrophoretically homogeneous preparations of cellobiase i and cellobiase ii have been obtained. by means of gel-filtration their molecular weights have been estimated to be 140,000 and 67,000. cellobiase i consists of five and cellobiase ii of two polypeptide chains. three cellulases with various ratios of endoglucanase and ex ...	1983	6878208
disseminated infection by aspergillus terreus.	a patient with acute nonlymphocytic leukemia who received chemotherapy developed lung nodules and later central nervous system symptoms consistent with disseminated aspergillosis. the diagnosis was made at open lung biopsy by culturing the organism and observing in tissue sections conidia borne laterally along the hyphae, a characteristic of the aspergillus terreus-flavipes group. this is the first reported case of disseminated a. terreus infection in an immunocompromised host.	1983	6637885
studies on metabolites produced by aspergillus terreus var. aureus. i. chemical structures and antimicrobial activities of metabolites isolated from culture broth.		1983	6671258
mutastein, a new inhibitor of adhesive-insoluble glucan synthesis by glucosyltransferases of streptococcus mutans.	mutastein, a new inhibitor of glucosyltransferases (gtase) of streptococcus mutans, was isolated from cultural broth of aspergillus terreus m3328. mutastein was a heat-stable protein and was sensitive to pronase digestion. in the formation of glucans, that of adhesive water-insoluble glucans of s. mutans was specifically inhibited by mutastein.	1983	6219978
aspergillus terreus endocarditis--a case report.		1983	6368727
a new era of exploitation of microbial metabolites.	in the past history of the pharmaceutical industry, secondary metabolites have been screened almost exclusively for antimicrobial activities. this biased and narrow view has severely limited the potential application of microbial metabolites. fortunately, this situation is changing and we are now entering into a new era in which microbial metabolites are being applied to diseases heretofore only subjected to synthetic compounds. this new approach is the application of microbial secondary metabol ...	1983	6400479
[regulation of the biosynthesis of endo-1,4-beta-glucanase, eco-1,4-beta-glucosidase and cellobiase in aspergillus terreus].	this work was aimed at studying how the biosynthesis of endo-1,4-beta-glucanase, exo-1,4-beta-glucosidase and cellobiase, components of the cellulase complex was regulated in an aspergillus terreus strain isolated from soil. the biosynthesis of endoglucanase and cellobiase was suppressed by readily metabolizable substrates and stimulated in the course of growth on lactose and celluloses. the activity of exoglucosidase was found in the medium only when the strain was grown on celluloses. cataboli ...	1983	6405133
[synthesis and secretion of the components of the cellulase complex in aspergillus terreus].	aspergillus terreus was found to have two functionally different cellobiases. one of them is excreted into the surrounding medium and is a part of the cellulase complex. the second one is an endocellular (or periplasmic) enzyme. it is distinguished by its stability, the time of mrna operation, the sorption of cell debris; moreover, its activity does not depend on changes in the parameters of the medium when the incubation mixture is replaced and the surface is treated with 0.5 m nacl. the synthe ...	1983	6413830
development of fluorescent-antibody reagents for demonstration of pseudallescheria boydii in tissues.	we prepared fluorescent-antibody reagents to detect and identify pseudallescheria boydii in tissue. antisera to broken mycelium and condidia (particulate antigens) and to culture filtrates (soluble antigens) of p. boydii were produced in rabbits. antisera and globulin fractions of the antisera were labeled with fluorescein isothiocyanate and evaluated for their ability to stain p. boydii in tissues. the conjugates were first tested with cultures of 25 p. boydii isolates and 26 heterologous fungi ...	1983	6195179
cellulolytic activity of moulds. ii. various methods of precipitating and concentrating enzymes and their influence on the activity of cellulolytic preparation and xylanase of aspergillus terreus f-413.	complexes of cellulolytic enzymes and xylanase were precipitated and concentrated by various methods from post-culture liquids of aspergillus terreus f-143, containing cellucotton as carbon source. the best results in regard to the specific activity of the preparations were obtained by precipitation of enzymes with acetone-denatured ethanol. besides high cellulolytic and xylanase activity the crude enzyme preparation showed the presence of small amounts of amylase, protease and polygalacturonase ...	1983	6202104
producton of single-cell protein from cellulose by aspergillus terreus.	cellulose fermentation studies were conducted with a thermotolerant strain of aspergillus terreus. batch cultivation of a. terreus using purified or complex cellulose showed that 80-88% of the available cellulose was utilized in 30-36 h with an average doubling time of 7.5-8.3 h. the protein content in the biomass ranged from 23 to 38%. semicontinuous cultivation studies, in which 90% of the biomass was withdrawn at the end of growth cycle, indicated that 84% of added cellulose was utilized with ...	1983	18551438
effect of nutritional factors on cellulase enzyme and microbial protein production by aspergillus terreus and its evaluation.	the biomass yield, cellulolytic activity, and protein recovery using aspergillus terreus gn1 with alkali-treated sugarcane bagasse was studied using different levels (250-600 mg of n/l of broth) of organic and inorganic nitrogen sources. e.g., cattle urine, urea, cornsteep liquor, ammonium sulfate, ammonium nitrate, ammonium iron sulfate, ammonium chloride, and sodium nitrate. among different levels of alkali-treated bagasse substrate concentrations (0.5-4.0% w/v) tested, 1.0% substrate yielded ...	1982	18546104
production of scp and cellulase by aspergillus terreus from bagasse substrate.	the fermentation of 1.0% untreated bagasse under optimum cultural and nutritional conditions with aspergillus terreus gn1 indicated that the maximum rate of protein and cellulase production could be obtained during three days of submerged fermentation. even though 16.4% protein recovery, 0.55 units cmcase/ml, and 0.027 fpase units/ml were obtained on the seventh day, the rates of increase in protein recovery and cellulase production were slower than those obtained up to these days, which were 14 ...	1982	18546213
studies on the properties of cellulase enzyme from aspergillus terreus gn1.		1982	18546360
purification and properties of beta-glucosidase from aspergillus terreus.	a beta-glucosidase (ec 3.2.1.21) from the fungus aspergillus terreus was purified to homogeneity as indicated by disc acrylamide gel electrophoresis. optimal activity was observed at ph 4.8 and 50 degrees c. the beta-glucosidase had k(m) values of 0.78 and 0.40 mm for p-nitrophenyl-beta-d-glucopyranoside and cellobiose, respectively. glucose was a competitive inhibitor, with a k(i) of 3.5 mm when p-nitrophenyl-beta-d-glucopyranoside was used as the substrate. the specific activity of the enzyme ...	1982	16346147
effect of a glucosyltransferase inhibitor on glucan synthesis and cellular adherence of streptococcus mutans.	the effects of mutastein, a glucosyltransferase inhibitor derived from an aspergillus terreus strain, on the glucan synthesis by glucosyltransferases of streptococcus mutans and sucrose-dependent adherence of s. mutans cells were examined in vitro. the synthesis of insoluble glucan by crude glucosyltransferase of s. mutans strain b13 was markedly inhibited by mutastein at a final concentration of 10 micrograms of protein/ml. the synthesis of insoluble glucan adherent to glass surfaces was almost ...	1982	6218092
cellulolytic activity of moulds. i. characteristics of the cellulases complex and xylanase of the strain aspergillus terreus f-413.	among 79 strains of moulds belonging to 17 different species, the strain aspergillus terreus f-413 which showed the highest cellulolytic activity was isolated for further studies. some properties of the complex of cellulases formed by this strain as well as the dynamics of their synthesis under optimal submerged culture conditions were characterized.	1982	6189375
the effects of mevinolin on serum cholesterol levels of rabbits with endogenous hypercholesterolemia.	mevinolin, a fungal metabolite isolated from cultures of aspergillus terreus, is a potent competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme a reductase, the rate-controlling enzyme in cholesterol biosynthesis. in the current studies we demonstrate that mevinolin significantly lowers serum cholesterol in rabbits fed a cholesterol free, low-fat semi-synthetic diet. rabbits maintained on this diet developed endogenous hypercholesterolemia with average cholesterol concentrations of 310 m ...	1982	6921995
aspergillus terreus infection of pseudoaneurysm of aortofemoral vascular graft with contiguous vertebral osteomyelitis.	this is a case report of a patient who developed several unusual complications of an aortofemoral vascular graft. these were thrombosis, pseudoaneurysm, and infection. there was an aspergillus terreus infection of the pseudoaneurysm of the vascular prosthesis. a contiguous vertebral osteomyelitis due to a. terreus subsequently developed. this represented a localized, invasive form of aspergillosis.	1982	7064922
aspergillus terreus, a pathogen capable of causing infective endocarditis, pulmonary mycetoma, and allergic bronchopulmonary aspergillosis.	aspergillus terreus is a rarely reported pathogen in humans, recovery of this organism from the sputum may therefore be discounted as representing contamination this report describes 3 patients--1 with allergic bronchopulmonary aspergillosis (abpa), 1 with aspergilloma, and 1 with infective endocarditis-- in whom a. terreus was proved to be the etiologic organism. together, these 3 cases span the spectrum of disease usually associated with a. fumigatus. detection of serum precipitins against asp ...	1982	7091887
[ultrastructural surface restructurings of the fungus aspergillus terreus growing on cellulose-containing substrate].	the ultrastructural organization of the cell wall surface was studied in the fungus aspergillus terreus 17p growing on different substrates: glucose, a sodium salt of carboxymethyl cellulose (cmc) which is a soluble derivative of cellulose, ground straw. cells grown on soluble substrates (glucose and na-cmc) had a smooth surface in the logarithmic growth phase. cells grown on straw, a solid insoluble substrate, released a substance of a polysaccharide nature which formed a thick fibrillar networ ...	1982	7121328
solvent systems for improved isolation and separation of territrems a and b.	territrems a and b, tremorgenic mycotoxins in the rice culture of aspergillus terreus, were extracted with hot chloroform. the toxins were cleaned on a silica gel column by direct adsorption-concentration of the extracts followed by desorption with chloroform-acetone (9:1, vol/vol). crude toxin mixtures were separated by silica gel column chromatography and eluted with benzene-ethyl acetate (65:35, vol/vol). the method gave 112 mg of territrem a, 379 mg of territrem b, and 80 mg of their mixture ...	1982	7149718
antitumor effect and structure-activity relationship of asterriquinone analogs.	asterriquinone (arq), a metabolic product from aspergillus terreus ifo 6123, showed an inhibitory effect on some transplantable animal tumors, ehrlich carcinoma, ascites hepatoma ah13 and mouse p388 leukemia, but had little or no effect on yoshida sarcoma, ascites hepatoma ah109a and mouse l1210 leukemia. arq also inhibited the growth of hela cells in monolayer culture. although metabolic products from aspergillus terreus var. africanus ifo 8835 were almost ineffective against ehrlich carcinoma, ...	1982	7152200
terrecyclic acid a, a new antibiotic from aspergillus terreus. i. taxonomy, production, and chemical and biological properties.		1982	7174531
terrecyclic acid a, a new antibiotic from aspergillus terreus. ii. structure of terrecyclic acid a.		1982	7174532
influence of ph on the formation and location of beta-glucosidase in aspergillus terreus grown on cellulose.	wild strain of aspergillus terreus is very good producer of beta-glucosidase. it produces 15 nkat/ml (0.9 iu/ml) of extracellular beta-glucosidase at ph 5.0. the medium ph level strongly affects the production and binding of beta-glucosidase on the cells and on residual cellulose. at ph 4.0 the rate of enzyme synthesis and the level of total activity is highest but 60-75% of this activity is bound. at higher ph levels the enzyme is mainly released to the medium.	1982	6815035
allergic bronchopulmonary aspergillosis (abpa) caused by aspergillus terreus: specific lymphocyte sensitization and antigen-directed serum opsonic activity.	a 16-year-old male presented with a history of asthma and recurrent pneumonia. a diagnosis of abpa was based upon the typical clinical presentation, peripheral eosinophilia, elevated ige and positive immediate skin tests to aspergillus. sputum cultures grew a. terreus, a rare cause of human disease. soluble and particulate antigens were prepared from this organism. precipitins against a. terreus, but not against a. fumigatus, were detected in the patient's serum. his lymphocytes proliferated mar ...	1981	6781385
[aspergillus terreus as a cause of mycotic abortion in cows].	the fungus aspergillus terreus thom et church was subjected to microscopic and cultivation study in the organs of an aborted foetus and was demonstrated to be the causative agent of abortion in cattle. the culture of the isolated organism is described and brief data reporting on its ecology are presented. attention is drawn to the probable source of infection and to the insufficiently known aspects of the pathogenesis of this disease.	1981	6782741
the microbiology of spent mushroom compost and its dust.	microorganisms in spent steamed mushroom compost and its dust were enumerated, and identified. some phase ii (indoor composting) compost samples were also examined. steaming of spent compost resulted in a 70-76% reduction in microbial numbers. total counts made with compost fusion agar were approximately two logs greater than those for nutrient agar. the most common bacterial isolate was bacillus licheniformis. the most common actinomycete isolates were streptomyces diastaticus and thermoactinom ...	1981	7197578
dihydromevinolin, a potent hypocholesterolemic metabolite produced by aspergillus terreus.	a new, potent hypocholesterolemic agent is produced by cultures of aspergillus terreus. the isolation of the compound and its characterization as 4a,5-dihydromevinolin containing a trans-fused octahydro-naphthalene system are described. comparative data for dihydromevinolin and mevinolin in three biological assays are given: in vitro inhibition of hmg-coa reductase, inhibition of sterol synthesis in cell cultures, and inhibition of cholesterol synthesis in vivo in rats.	1981	7275832
acute-phase reactants in experimental inhalation lung disease.	an investigation on the occurrence and role of acute-phase reactants in experimental inhalation lung disease (ild) was undertaken. using an experimental model of ild in which rabbits are exposed to aerosols of appropriate fungal spores, haptoglobin analysis was compared with depressions in arterial oxygen tension (pao2) with time following challenge. haptoglobin values of rabbits exposed to single 30-min aerosol challenges of aspergillus terreus, demonstrated a significant (two- to three fold) i ...	1981	7323066
aspergillus terreus infective endocarditis on a porcine heterograft valve.	we present the first reported case of aspergillus endocarditis occurring on a porcine heterograft prosthesis and discuss the literature regarding both aspergillus endocarditis and endocarditis on a porcine valve. a 65-year-old man underwent aortic valve replacement with a porcine heterograft. several weeks later he exhibited signs of infection and then of valve failure. upon removal, the porcine valve substance was found to be grossly infiltrated and destroyed by the aspergillus organism. the po ...	1980	7351851
sem studies on the in vivo uptake of aspergillus terreus spores by alveolar macrophages.	pulmonary reactions to fungal spores constitute an important aspect of occupational pneumoconioses. experimental models using aerosols of aspergillus terreus spores produce an acute, complement dependent, hypoxic reaction in rabbits. the purpose of this study was to explore the possible role of the alveolar macrophage in initiating this reaction. rabbits and rats were intratracheally injected with aspergillus spores and the fate of the spores was studied at various times thereafter by light and ...	1980	7414272
isocitrate lyase from aspergillus terreus irrl 16043.		1980	7429598
studies on terreic acid.	it was found that aspergillus sp. no. y-8980 which was isolated from a soil sample collected at yoron island in kagoshima prefecture belonged to aspergillus terreus group by morphological observation. the active substance produced by the strain was obtained with a high yield in sucrose-yeast extract medium and extracted by chloroform, ethyl acetate and n-butanol at ph 2.4 approximately 2.6 from the culture broth. the substance was crystallized from chloroform and ethyl acetate after charcoal tre ...	1980	7190624
mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme a reductase and a cholesterol-lowering agent.	mevinolin, a fungal metabolite, was isolated from cultures of aspergillus terreus. the structure and absolute configuration of mevinolini and its open acid form, mevinolinic acid, were determined by a combination of physical techniques. mevinolin was shown to be 1,2,6,7,8,8a-hexahydro-beta, delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthalene-hepatanoic acid delta-lactone. mevinolin in the hydroxy-acid form, mevinolinic acid, is a potent competitive inhibitor of 3-hydroxy-3-methyl ...	1980	6933445
citreoviridins from aspergillus terreus.		1980	6773444
the effects of 2,4-dichlorophenoxyacetic acid on respiration, nitrogen and carbohydrate metabolism of aspergillus terreus thom.	the effects of 2,4-d on respiration, carbohydrate and nitrogen metabolism have excited much interest in relation to higher plants (hansen 1946, hseuth and lou 1946, smith et al. 1947, and said and naguib 1955). but the effects of 2,4-d on dungi have been tackled to a much less extent (guiscafre-arrilaga 1948, bever and slife 1948, wei and ling 1948, and manil and strazewska 1950). these investigators studied the effects exerted on fungal growth. said and naguib (1962) studied the effect of 2,4-d ...	1980	6775436