Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| evaluation of the effect of l: -thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism. | subclinical hypothyroidism (sh) is characterized by normal serum free t4 (ft4), free t3 (ft3) levels and increased serum thyroid-stimulating hormone (tsh) levels. endothelial dysfunction, which is an early step of atherosclerosis, has been reported in patients with subclinical hypothyroidism. the aim of this study is to evaluate endothelial functions and the effect of l: -thyroxin (l-t4) therapy on endothelial functions in sh. twenty-seven patients with sh and 22 healthy controls were evaluated ... | 2011 | 21505892 |
| t4-like genome organization of the escherichia coli o157:h7 lytic phage ar1. | we report the genome organization and analysis of the first completely sequenced t4-like phage ar1 of e. coli o157:h7. unlike most of the other sequenced phages of o157:h7 strain that belong to the temperate podoviridae and siphoviridae families, ar1 is a t4-like phage known to efficiently infect this pathogenic bacterial strain. the 167,435-bp ar1 genome is currently the largest among all the sequenced e. coli o157:h7 phages. it encodes a total of 281 potential orfs and ten putative trna genes. ... | 2011 | 21507986 |
| variation of the position of the aorta relative to a kyphotic thoracic spine: safety margin for pedicle screw placement in the adult japanese population. | abstract: study design: an analysis of computed tomography images of the spine in adult japanese patients.objective: to evaluate the variation of the position of the aorta relative to a spine with a thoracic kyphotic angle and to verify the safety margin for transpedicular screw fixation.summary of background data: recent studies have suggested that the aorta is positioned more laterally and posteriorly in patients with idiopathic scoliosis than in normal patients; however, variation of the posi ... | 2011 | 21508888 |
| nociceptive inputs transmission in huntington's disease: a study by laser evoked potentials. | the aim of the present study was to evaluate pain perception and evoked responses by laser stimuli (leps) in mild not demented huntington's disease (hd) patients. twenty-eight hd patients and 30 control subjects were selected. leps were obtained by four scalp electrodes, (fz, cz, referred to the nasion; t3, t4, referred to fz), stimulating the dorsum of both hands. all patients were also evaluated by somatosensory evoked potentials (seps) by median nerve stimulation. only 3 patients referred pai ... | 2011 | 21510231 |
| the effects of bromazepam over the temporo-parietal areas during the performance of a visuomotor task: a qeeg study. | this study investigated the effects of bromazepam on qeeg when 14 healthy subjects were asked to perform a visuomotor task (i.e., motor vehicle driving task). the subjects were exposed to two experimental conditions: the placebo (pl) and 6mg of bromazepam (br 6mg), following a randomized, double-blind design on different days. specifically, we observe absolute power extracted from qeeg data for theta band. we expected to see a decrease in absolute theta power in the temporal and parietal areas d ... | 2011 | 21511002 |
| mct8: from gene to disease and therapeutic approach. | thyroid hormone metabolism and action are largely intracellular processes that require transport of the hormone across the plasma membrane by different transporters. two of these, mct8 and mct10, are close members of the monocarboxylate transporter family. mct8 is expressed in a variety of tissues, including liver, kidney, thyroid and brain. the mct8 gene is located on the x chromosome, and mutations in mct8 result in severe psychomotor retardation and low serum t4 and high t3 levels in affected ... | 2011 | 21511238 |
| development of hepatocellular carcinomas in patients with absence of tumors on a prior ultrasound examination. | background: to evaluate hepatocellular carcinoma (hcc) that developed in patients with no evidence of a tumor during a prior ultrasound (us) performed within 1 year of the diagnosis. methods: we retrospectively analyzed data for 100 consecutive patients with liver cirrhosis who had undergone us within 1 year prior to hcc diagnosis and who showed no liver lesions on the previous us. size and t stage of hcc were assessed as well as whether patients met surgical criteria for liver transplantation a ... | 2011 | 21514759 |
| effect of a combined iodine and selenium supplementation on i and se status of cows and their calves. | iodine (i) and selenium (se) deficiencies are commonly reported in cattle, however, there are also studies regarding a very high iodine supply. the aim of the study was to determine the long-term effect of i and se supplementation on non-pregnant cows, pregnant cows and their calves. the hypothalamus pituitary axis was investigated (tsh, t4, t3 assays) during a trh challenge on non-pregnant cows. twenty-four cows, half of them pregnant, were assigned into 2 diet-groups, one group with a low i (0 ... | 2011 | 21514807 |
| [clinical analysis of malignant submandibular tumor]. | the 14 cases of malignant submandibular tumor whose treatment outcome we analyzed between 1989 and 2008 included 5 of adenoid cystic carcinoma, 3 of squamous cell carcinoma, 2 each of mucoepidermoid carcinoma, and carcinoma ex pleomorphic adenoma, and 1 each of carcinosarcoma and large-cell carcinoma. one subject was diagnosed with t1, 7 with t2, 4 with t3, and 2 with t4. lymph node involvement occurred in 5, -1 with n1 and 4 with n2. none had distant metastasis on the first visit. seven were tr ... | 2011 | 21516710 |
| in vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol a. | bisphenol a (bpa) is a chemical with high production volume and wide applications in many industries. although bpa is known as an endocrine disruptor, its toxic mechanisms have not been fully characterized. due to its structural similarity to thyroid hormones thyroxine (t4) and triiodothyronine (t3), one possible mechanism of bpa toxicity is disruption of hormone transport by competitive binding with the transport proteins. in this study, the binding interactions of bpa, t4, and t3 with three th ... | 2011 | 21517007 |
| neoadjuvant chemotherapy for locally advanced breast cancer in a malaysian tertiary hospital. | introduction: neoadjuvant chemotherapy for locally advanced breast cancer is given with the aim of shrinking the disease sufficiently for surgery. however, many clinical trials investigating neoadjuvant chemotherapy regimens were conducted for operable breast cancer. methods and materials: patients with t3-4, n2 m0 breast cancer diagnosed between january 2005 and december 2008 and who received at least one cycle of neoadjuvant chemotherapy were eligible for this study. thirty-four patients were ... | 2011 | 21517250 |
| a case of tsh-producing adenoma treated with octreotide in combination with thiamazole for the control of tsh and thyroid hormones after trans-sphenoidal neurosurgery. | while tsh-producing adenoma (tshoma) is rare, the diagnosis is often delayed because the clinical features are heterogeneous. the patient was a 69-year-old woman who had been referred to the yachiyo medical center in august 2008, because of dyspnea, loss of appetite, weight loss of 10 kg, and diarrhea that lasted 4 years. we diagnosed this patient with pituitary tsh-producing macroadenoma. thyroid hormone concentration was increasing although the serum tsh level was within a normal range after t ... | 2011 | 21519153 |
| full-dose capecitabine with local radiotherapy: one of the treatment options for inoperable t4 breast cancer. | a 48-year-old woman presented with a 15-cm diameter tumor in her left breast with fixation to the chest wall and palpable axillary lymph nodes. pathology study showed pure-type mucinous carcinoma. pretreatment staging investigations showed multiple lung metastases, which resulted in the diagnosis of t4n2m1 breast cancer. four cycles of cyclophosphamide 700 mg/m(2)/epirubicin 70 mg/m(2) (ce) were performed initially, but the tumors decreased only within the treatment response criteria of stable d ... | 2011 | 21519998 |
| [effective reversal of muscle relaxation by rocuronium using sugammadex in a patient with myasthenia gravis undergoing laparoscopic cholecystectomy]. | as myasthenia gravis affects neuromuscular transmission, these patients show various responses to neuromuscular blocking drugs. we report a successful use of the sugammadex in a myasthenic patient to reverse rocuronium-induced neuromuscular block. a 69-year-old woman was scheduled for laparoscopic cholecystectomy and total of rocuronium 20 mg was administered. after spontaneous recovery of t1, we administered sugammadex 200mg intravenously, reversing neuromuscular blockade to a train-of-four rat ... | 2011 | 21520600 |
| [bladder preservation using chemoradiation therapy for locally invasive bladder cancer]. | we investigated the long-term results and molecular markers of outcome with selective organ preservation in invasive bladder cancer using chemoradiation therapy. | 2011 | 21520632 |
| diagnosis and treatment of hypothyroidism in tsh deficiency compared to primary thyroid disease: pituitary patients are at risk of under-replacement with levothyroxine. | objective achieving optimal thyroid hormone replacement is more difficult in tsh deficiency compared to primary hypothyroidism because of the inability to be guided by serum tsh levels. a combination of clinical symptoms and free thyroxine levels (ft4) are typically used to make a diagnosis and monitor replacement. we investigated the diagnosis of tsh deficiency in patients with pituitary disease and the adequacy of levothyroxine replacement compared with primary thyroid disease. design using ... | 2011 | 21521256 |
| association of thyroid autoimmunity with acne in adult women. | background during the last decades an increase has been observed regarding acne in adults and especially women. objective to evaluate the association between thyroid disorder and the presence of post-adolescent acne in adult women, comparing with healthy controls. methods 107 adult women with post-adolescent acne and 60 healthy controls were included. complete blood count and standard biochemical profile of c-reactive protein (crp) and levels of thyroid hormones and antibodies [triiodothyroni ... | 2011 | 21521376 |
| hair regrowth with topical triiodothyronine ointment in patients with alopecia areata: a double-blind, randomized pilot clinical trial of efficacy. | background thyroid hormone receptors are expressed in hair follicles and it is known that thyroid hormones can have a positive effect on hair growth, i.e. process which is disrupted in alopecia areata. objectives the aim of this study was to determine the efficacy of topical triiodothyronine in patients with patchy alopecia areata. methods ten patients with patchy alopecia areata were treated with triiodothyronine and placebo applied twice daily to either of two bilaterally symmetrical patche ... | 2011 | 21521379 |
| inability of rhtsh to predict the evolution from subclinical hypothyroidism to overt disease. a pilot study. | background: the use of recombinant human tsh is indicated to evaluate thyroid carcinoma patients. in recent years, some authors have reported that rhtsh could serve as a dynamic test of thyroid reserve. the aim of the present study was to determine whether or not rhtsh can predict the evolution from subclinical hypothyroidism (sh) to overt hypothyroidism. materials and methods: twenty-one women who met the diagnostic criteria of sh were enrolled. all patients received a single dose of rhtsh (0.1 ... | 2011 | 21521938 |
| the influence of prognostic factors and adjuvant chemoradiation on survival after pancreaticoduodenectomy for ampullary carcinoma. | introduction: the prognosis after pancreaticoduodenectomy (pd) for ampullary carcinoma (ac) is superior to that of pancreatic cancer. decisions regarding adjuvant therapy are influenced by factors such as nodal status, stage, and grade, but the influence of these individual variables on survival is unclear. methods: a prospective tumor registry database was queried to identify patients who underwent pd for ac at thomas jefferson university between jan 1997 and apr 2009. the study was conducted w ... | 2011 | 21523621 |
| patterns of extralaryngeal spread of laryngeal cancer: thyroid cartilage penetration occurs in a minority of patients with extralaryngeal spread of laryngeal squamous cell cancers. | background: laryngeal preservation programs for patients with advanced laryngeal squamous cell carcinomas (scc) have generally excluded patients with t4 disease. the accuracy of preoperative imaging in evaluating thyroid cartilage penetration and extralaryngeal spread (els) has previously been questioned. clinically, scc spread into noncartilaginous structures may have less of a functional impact when compared with thyroid cartilage penetration. the current study was designed to characterize and ... | 2011 | 21523761 |
| expression and function role of dna methyltransferase 1 in human bladder cancer. | background: the identification of potential tumor markers will help improve therapeutic planning and patient management. therefore, the aim of this study was to highlight the role of dna methyltransferase 1 (dnmt1) in bladder cancer. methods: a total of 50 samples of nonmalignant urothelium, 65 of muscle-invasive bladder cancers, 15 of distant metastasis, and 50 of nonmuscle-invasive bladder cancers were selected for immunohistochemical staining analysis. furthermore, human bladder cancer cell l ... | 2011 | 21523767 |
| ultrasensitive microarray detection of short rna sequences with enzymatically modified nanoparticles and surface plasmon resonance imaging measurements. | a novel multiplexed method for short rna detection that employs an enzymatic capture reaction onto dna-modified silica nanoparticles (sinps) followed by nanoparticle-enhanced surface plasmon resonance imaging (spri) is demonstrated. sinps functionalized with 5'-phosphorylated single stranded dna (ssdna) are used with t4 rna ligase to capture various short 20-24 base single-stranded rna (ssrna) oligonucleotides from a target solution. the ssrna-modified sinps are collected from the target solutio ... | 2011 | 21524060 |
| metabolism and gastric remnant changes after roux-en-y gastric bypass in rats. | abstract background: the roux-en-y gastric bypass (rygb) may affect metabolism, microbiology, and histology of gastric remnant. therefore, this study aimed to investigate these issues in rats. methods: twelve rats were randomly allocated to a rygb group (n = 6) and nonoperated normal rats group (n = 6). after 30 postoperative days, all rats were injected with 0.1ml of na(99m)tc(-) i.v. (radioactivity 0.66 mbq). after 30 min, liver, stomach, thyroid, heart, lung, kidney, and femur samples were ha ... | 2011 | 21524176 |
| sequence characteristics of t4-like bacteriophage ime08 benome termini revealed by high throughput sequencing. | abstract: | 2011 | 21524290 |
| massive levothyroxine ingestion in a pediatric patient: case report and discussion. | abstractwe describe the course of a toddler who ingested a massive amount of levothyroxine and review treatment options for such overdoses. a 2½-year-old boy presented shortly after an ingestion of up to 7.6 mg of levothyroxine (potentially as much as 700 μg/kg). he was initially asymptomatic, treated with oral charcoal 1 g/kg, and discharged home from the emergency department after a few hours. he returned approximately 24 hours later with a temperature of 38.5°c, heart rate of 163 beats per mi ... | 2011 | 21524373 |
| correlation between fas and fasl proteins expression in normal gastric mucosa and gastric cancer. | the study's objective was to assess the expressions of fas and fasl proteins in gastric cancer in correlation with chosen clinicohistological parameters. fas and fasl expression was analyzed in 68 patients with gastric cancer, using the immunohistochemical method. the expression of fas was found to be lower in gastric cancer cells than in healthy mucosa, both in the lining epithelium and in glandular tubes (28% vs. 48% and 44%; p 〈 0.001). the expression of fasl was also markedly lower in cancer ... | 2011 | 21526501 |
| thyroid autoimmunity role in the evolution of endemic goiter in rural area, fars, iran. | who reports indicate no iodine insufficiency in iran, however, goiter is still endemic in fars province. this study evaluates the role of thyroid autoimmunity in the evolution of endemic goiter. | 2011 | 21529102 |
| treatment of a malignant peripheral nerve sheath tumor and its complications through a multidisciplinary approach. | the authors report the case of a 14-year-old girl with a residual malignant peripheral nerve sheath tumor after thoracotomy, chemotherapy, and radiation therapy. the residual tumor, which involved the intercostal muscles, aorta, and neural foramina of t4-10, was completely resected through a costotransversectomy and multiple hemilaminotomies with the patient in the prone position and was stabilized using a t1-12 pedicle screw fusion. postoperatively, the patient developed several infections requ ... | 2011 | 21529197 |
| titanium plates and dualmesh: a modern combination for reconstructing very large chest wall defects. | the reconstruction of large full-thickness chest wall defects after resection of t3/t4 non-small cell lung carcinomas or primary chest wall tumors presents a technical challenge for thoracic surgeons and plays a central role in determining postoperative morbidity. the objective is to evaluate our results in chest wall reconstruction using a combination of expanded polytetrafluoroethylene (eptfe) mesh and titanium plates. | 2011 | 21531380 |
| effects of hyperthyroidism, hypothyroidism and thyroid autoimmunity on female sexual function. | introduction: thyroid hormones affect male and female sexual functions, but data in hypo- and hyperthyroid women are scanty. aim: to investigate sexual function in hypo- and hyperthyroid women before and immediately after restoration of euthyroidism and in women with euthyroid hashimoto's thyroiditis (ht). patients and controls: fifty-six women with thyroid diseases (age 19-50 years; 22 with hyperthyroidism, 17 with hypothyroidism and 17 with euthyroid ht) and 30 age-matched healthy women. main ... | 2011 | 21532331 |
| acute t3 treatment protects the heart against ischemia-reperfusion injury via tra1 receptor. | we have previously shown that acute thyroid hormone treatment could limit reperfusion injury and increase post-ischemic recovery of function. in the present study, we further explore potential initiating mechanisms of this response. thus, isolated rat hearts were subjected to 30 min zero-flow global ischemia (i) followed by 60-min reperfusion (r). reperfusion injury was assessed by post-ischemic recovery of left ventricular developed pressure (lvdp%) and ldh release. t3 at a dose of 60 nm which ... | 2011 | 21442236 |
| [effect of acupuncture-assisted anesthesia on stress response during laparoscopic cholecystectomy in aged patients]. | to compare the difference between transcutaneous electrical acupoint stimulation (teas) assisted general anesthesia and simple general anesthesia on stress response during laparoscopic cholecystectomy (lc) in aged patients. | 2011 | 21442823 |
| physiological and therapeutical roles of ginger and turmeric on endocrine functions. | the natural product ginger (zingiber officinale) has active constituents gingerol, shogaol and zerumbone, while turmeric (curcuma longa) contains three active major curcuminoids, namely, curcumin, demethoxycurcumin, and bisdemethoxycurcumin. they have the same scientific classification and are reported to have anti-inflammatory and many therapeutic effects. this article reviews the physiological and therapeutic effects of ginger and turmeric on some endocrine gland functions, and signal pathways ... | 2011 | 21476200 |
| predicting ideal spinopelvic balance in adult spinal deformity. | object spinopelvic balance is based on the theory that adjacent segments of the spine are related and influenced by one another. by understanding the correlation between the thoracolumbar spine and the pelvis, a concept of spinopelvic balance can be applied to adult deformity. the purpose of this study was to develop a mathematical relationship between the pelvis and spine and apply it to a population of adults who had undergone spinal deformity surgery to determine whether patients in spinopelv ... | 2011 | 21476795 |
| image-guided radiotherapy for prostate cancer: a prospective trial of concomitant boost using indium-111-capromab pendetide (prostascint) imaging. | purpose: to evaluate, in a prospective study, the use of (111)in-capromab pendetide (prostascint) scan to guide the delivery of a concomitant boost to intraprostatic region showing increased uptake while treating the entire gland with intensity-modulated radiotherapy for localized prostate cancer. methods and materials: from september 2002 to november 2005, 71 patients were enrolled. planning pelvic ct and (111)in-capromab pendetide scan images were coregistered. the entire prostate gland receiv ... | 2011 | 21477947 |
| implications of the inability of listeria monocytogenes egd-e to grow anaerobically due to a deletion in the class iii nrdd ribonucleotide reductase for its use as a model laboratory strain. | listeria monocytogenes is a gram-positive facultative intracellular bacterium that causes life-threatening diseases in humans. it grows and survives in environments of low oxygen tension and under conditions of strict anaerobiosis. oxygen-limiting conditions may be an important factor in determining its pathogenicity. l. monocytogenes serovar 1/2a strain egd-e has been employed intensively to elucidate the mechanisms of intracellular multiplication and virulence. listeria possesses genes encodin ... | 2011 | 21478338 |
| rna captor: a tool for rna characterization. | in the genome era, characterizing the structure and the function of rna molecules remains a major challenge. alternative transcripts and non-protein-coding genes are poorly recognized by the current genome-annotation algorithms and efficient tools are needed to isolate the less-abundant or stable rnas. | 2011 | 21533245 |
| shine-dalgarno sequence of bacteriophage t4: gagg prevails in early genes. | translation initiation is governed by a limited number of mrna sequence motifs within the translation initiation region (tir). in bacteria and bacteriophages, one of the most important determinants is a shine-dalgarno (sd) sequence that base pairs with the anti-sd sequence gaucaccuccuua localized in the 3' end of 16s rrna. this work assesses a diversity of tir features in phage t4, focusing on the sd sequence, its spacing to the start codon and relationship to gene expression and essentiality pa ... | 2011 | 21533668 |
| thyroid status in a large cohort of patients with mental retardation: the top-r (thyroid origin of psychomotor retardation) study. | objective: abnormalities in thyroid state may affect development and function of the brain and result in mental retardation (mr). thyroid parameters have not been systematically investigated in institutionalized mr subjects. the objective is to measure thyroid parameters in a novel cohort of 946 institutionalized subjects. design: the top-r (thyroid origin of psychomotor retardation) study is a cross-sectional nation-wide multi-centre study. patients: subjects with unexplained mr. results: t ... | 2011 | 21535074 |
| supranutritional selenium level affects fatty acid composition and oxidative stability of chicken breast muscle tissue. | a total of 128 broilers were used to investigate the effect of selenium (se) on fatty acid (fa) composition and oxidative stability of lipids in the breast muscle tissue. there were 4 replicates of 4 dietary treatments: t1 (basal diet with no added se), t2 (t1 with 0.15 mg se added per kg diet), t3 (t1 with 0.3 mg se added per kg diet) and t4 (t1 with 3.0 mg se added per kg diet). a yeast source was used for added se. breast muscle tissue was collected from two chickens per replicate pen for the ... | 2011 | 21535232 |
| molecular characterization of a novel type ii keratin gene (sseker3) in the senegalese sole (solea senegalensis): differential expression of keratin genes by salinity. | keratins make up the largest subgroup of intermediate filaments and, in chordates, represent the most abundant proteins in epithelial cells. senegalese sole (solea senegalensis) is a commercially important flatfish in which only two type i keratin genes, sseker1 and sseker2, have been described. we obtained the entire cdnas encoding for a novel type ii keratin, referred to as sseker3. main features and sequence identities with other fish and mammalian type ii keratins are described. expression p ... | 2011 | 21536146 |
| [comparative study of oncologic outcomes after multivisceral resection for stage iic colorectal cancer between inflammatory and malignant adhesion]. | to evaluate the differences in oncologic outcomes between inflammatory adhesion and malignant adhesion in patients with stage iic colorectal cancer after multivisceral resection(mvr). | 2011 | 21538269 |
| electroneutral cation-cl(-) cotransporters nkcc2β and nccβ expressed in the intestinal tract of japanese eel anguilla japonica. | in the present study, we aimed to elucidate the mechanisms of intestinal na(+) and cl(-) absorption in japanese eel, focusing on electroneutral cation-cl(-) cotransporters, nkcc2β and nccβ, expressed in the intestinal tract. first, we cloned cdnas encoding nkcc2β and nccβ from the intestinal tract of japanese eel. in both freshwater- and seawater-acclimated eels, quantitative pcr analysis showed that nkcc2β was predominantly expressed in the anterior and posterior intestines, and that nccβ expre ... | 2011 | 21539929 |
| multivariable analysis of factors associated with hospital readmission following pancreaticoduodenectomy for malignant diseases. | readmission rates after pancreaticoduodenectomy (pd) for malignant diseases have a significant impact on survival rate. identification of risk factors for readmission may improve discharge plans and postoperative care. data exist on the morbidity and mortality of patients undergoing pd, but there are few reports about hospital readmissions after this procedure. our aims were to evaluate the proportion and reasons for readmissions after pd for malignant diseases, the factors influencing readmissi ... | 2011 | 21542962 |
| genetic causes of congenital hypothyroidism due to dyshormonogenesis. | purpose of review: overview of congenital hypothyroidism caused by thyroid hormone synthesis defects, the current understanding of their pathophysiology, and clinical implications of molecular diagnoses. recent findings: genetic defects in all known thyroid-specific factors required for thyroid hormone synthesis have been described. these include defects in iodide trapping (nis), in the facilitated iodide efflux across the apical membrane (pds), the organification of iodide within the follicular ... | 2011 | 21543982 |
| developmental associations between externalizing behaviors, peer delinquency, drug use, perceived neighborhood crime, and violent behavior in urban communities. | this study examines the precursors of violent behavior among urban, racial/ethnic minority adults. data are from an on-going study of male and female african americans and puerto ricans, interviewed at four time waves, time 1-time 4 (t1-t4), from adolescence to adulthood. structural equation modeling was used to analyze the developmental pathways, beginning in mid-adolescence (t1; age = 14.0 years), to violent behavior in adulthood (t4; age = 29.2 years). the variables assessed were: components ... | 2011 | 21544831 |
| toxicologic and immunologic effects of perinatal exposure to the brominated diphenyl ether (bde) mixture de-71 in the sprague-dawley rat. | brominated diphenyl ethers (bdes) are persistent environmental contaminants found in human blood, tissues, and milk. to assess the impact of the commercial bde mixture de-71 on the developing immune system in relation to hepatic and thyroid changes, adult (f0) rats were exposed to de-71 by gavage at doses of 0, 0.5, 5, or 25 mg/kg body weight (bw)/d for 21 weeks. f0 rats were bred and exposure continued through gestation, lactation and postweaning. f1 pups were weaned and exposed to de-71 by gav ... | 2011 | 21544923 |
| thyroid dysfunction following therapeutic external radiation to head and neck cancer. | aim: the aim of the present study was to evaluate changes in thyroid function in patients with head and neck cancer treated with external beam radiotherapy (ebrt). materials and methods: this prospective study was conducted on ninety patients with non-thyroid head and neck cancer who were referred to the department of radiotherapy. thyroid function tests were conducted before, midway during and after ebrt, with follow up at monthly intervals up to 6 months after the completion of therapy. result ... | 2011 | 21545210 |
| accumulation and debromination of decabromodiphenyl ether (bde-209) in juvenile fathead minnows (pimephales promelas) induces thyroid disruption and liver alterations. | polybrominated diphenyl ether (pbde) flame retardants are known to affect thyroid hormone regulation. the thyroid hormone regulating deiodinases have been implicated in these impacts; however, pbde effects on the fish thyroid system are largely unknown. moreover, the liver as a potential target of pbde toxicity has not been explored in young fish. this study measured bde-209 effects on thyroid hormone regulation by measuring deiodinase activity in juvenile fathead minnows (pimephales promelas). ... | 2011 | 21546348 |
| [application of anterolateral thigh myocutaneous flap in the reconstruction of tongue and mouth floor defect after tongue carcinoma]. | to investigate the application of free anterolateral thigh myocutaneous flap in the reconstruction of tongue and mouth floor defect after radical resection of tongue carcinoma. | 2011 | 21548379 |
| sentinel-lymph-node procedure in colon and rectal cancer: a systematic review and meta-analysis. | no consensus exists on the validity of the sentinel-lymph-node procedure for assessment of nodal status in patients with colorectal cancer. we aimed to assess the diagnostic performance of this procedure. | 2011 | 21549638 |
| association of chfr promoter methylation with disease recurrence in locally advanced colon cancer. | purpose: this study was designed to determine whether dna methylation biomarkers are associated with recurrence and survival in colon cancer patients. experimental design: a retrospective analysis of 82 patients who received curative surgical resection for ajcc high-risk stage ii or iii colon cancer (1999-2007) was conducted. dna methylation status was quantitatively evaluated by the pyrosequencing method. we preselected three tumor-suppressor genes and one locus of interest; chfr, id4, reck, an ... | 2011 | 21551253 |
| algoriphagus aquaeductus sp. nov., isolated from a freshwater pipe. | a gram-negative, aerobic to microaerophilic, rod-shaped, red-colored bacterium, strain t4(t), was isolated from a freshwater pipe on tenerife island. a polyphasic taxonomic study was performed in order to characterise the strain in detail. the isolate is surrounded by a slime capsula and occurs single, in form of short chains, or in aggregates and exhibits catalase and oxidase activities. growth was observed at 15-42 °c. best growth of the bacterium occurred at ph 8 with mono- and disaccharides, ... | 2011 | 21551331 |
| [influence of pre-operative fasting time on blood glucose in older patients.] | purpose: this study was performed to identify changes in blood glucose at preoperative fasting time in surgical patients over 60 yr. methods: data collection was performed from july, 2008 through july, 2009. participants consisted of 80 nondiabetic surgical patients. blood glucose was checked from 3 to 5 times. the 5 times were 2-hr fasting on the pre-operative day (t1, n=80), 8 hr (t2, n=80), 10 hr (t3, n=17), 12 hr (t4, n=34) and 14 hr fasting on the day of the operation (t5, n=29). results: o ... | 2011 | 21551986 |
| prognostic factors for locoregional recurrence and survival in stage iiic breast carcinoma: impact of adjuvant radiotherapy. | introduction: the aims of the present study were to define the prognostic factors for locoregional recurrence (lrr) and survival in stage iiic breast carcinoma as well as to examine the impact of adjuvant radiotherapy on the outcome of the disease. methods: the records of 586 consecutive patients with stage iiic breast carcinoma who underwent modified radical mastectomy were evaluated, and the prognostic factors for lrr and survival were analysed. survival curves were generated using the kaplan- ... | 2011 | 21552792 |
| evaluation of factors affecting post-treatment quality of life in oral and oropharyngeal cancer patients primarily treated with curative surgery: an exploratory study. | the aim was to explore the impact of important clinico-demographic factors on the post-treatment quality of life (qol) in surgically treated oral and oropharyngeal cancer patients. 63 consecutive follow-up oral and oropharyngeal cancer patients treated primarily with surgery were recruited. 55 patients sent the completed questionnaires and finally included in this study. qol and important sub-domains of the qol were assessed. mean qol scores (sd) were computed, level of significance was set at p ... | 2011 | 21553147 |
| increased risk of advanced prostate cancer associated with mnsod ala-9-val gene polymorphism. | we aimed to investigate the association between manganese superoxide dismutase (mnsod) ala-9-val gene polymorphism and the initiation and/or progression of prostate cancer (pca) as well as to evaluate its potential interactions with advanced age and smoking status. mnsod ala-9-val gene polymorphism was carried out in 134 (mean age 64.1 ± 7.48) pca patients and 159 (mean age 62.5 ± 7.53) healthy controls with serum prostate specific antigen (psa) levels (<4 ng/ml) and normal digital rectal examin ... | 2011 | 21553226 |
| clinical significance of lymph node ratio and location of nodal involvement in patients with right colon cancer. | background/aims: increasing negative lymph node count has been reported to be associated with better outcomes in patients with colon cancer. the present study aimed to clarify the clinical significance of the lymph node ratio (lnr) and location of lymph node metastasis (lnm) in patients with stage iii right colon cancer. methods: we enrolled 820 patients who had undergone curative resection due to colon cancer at a single institution between 1991 and 2005. among them, 197 underwent curative rese ... | 2011 | 21555889 |
| neoadjuvant accelerated concomitant boost radiotherapy and multidrug chemotherapy in locally advanced rectal cancer: a dose-escalation study. | objectives: to determine the maximal and safely dose of preoperative radiotherapy and concurrently intensified chemotherapy regimen (raltitrexed plus oxaliplatin) in locally advanced rectal cancer patients. methods: patients with ct3-t4 and/or cn≥1 or locally recurrent rectal cancer were sequentially assigned to 4 treatment schedules of chemoradiation: standard radiotherapy (50.4 gy/5.5 wk) plus raltitrexed (cohort a), accelerated radiotherapy (55 gy/5 wk) plus raltitrexed (cohort b), standard r ... | 2011 | 21555930 |
| optimal margins and lymphadenectomy in colonic cancer surgery. | background: a standard management policy has not yet been established with respect to the extent of lymphadenectomy for colonic cancer. methods: a total of 914 consecutive patients who underwent potentially curative surgery for t2-t4 colonic cancer were reviewed retrospectively. the number of lymph nodes (lns) examined and the potential contributions to the staging accuracy of the distinct area were analysed. the survival benefit of dissection was compared for pericolic (local), mesocolic (inter ... | 2011 | 21560120 |
| genetic variation in the toll-like receptor 4 and prostate cancer incidence and mortality. | background: common genetic variants in the toll-like receptor 4 (tlr4), which is involved in inflammation and immune response pathways, may be important for prostate cancer. methods: in a large nested case-control study of prostate cancer in the physicians' health study (1982-2004), 10 single nucleotide polymorphisms (snps) were selected and genotyped to capture common variation within the tlr4 gene as well as 5 kb up and downstream. unconditional logistic regression was used to assess associati ... | 2011 | 21563195 |
| feasibility study for a controllable orthotic knee joint. | purpose. the purpose of this study was to demonstrate the feasibility of producing an orthotic knee joint that could lock and unlock during ambulation for eventual use in a reciprocating gait orthosis (rgo) for severely disabled patients. method. three prototype orthotic knee joints incorporating braking mechanisms were designed and manufactured to demonstrate their ability to withstand a maximum calculated sagittal plane bending moment of 73 nm. each was then subjected to bench trials to test t ... | 2011 | 21563970 |
| thyroid function after controlled ovarian hyperstimulation in women with and without the hyperstimulation syndrome. | objective: to investigate the impact of ovarian hyperstimulation syndrome (ohss) on thyroid function in women without thyroid disorders and to compare it with that in women with uncomplicated controlled ovarian hyperstimulation (coh). design: retrospective analysis. setting: tertiary referral fertility center. patient(s): a total of 77 women undergoing coh of whom 25 developed ohss and 52 had no ohss. women with the presence of thyroid disorders were excluded, and only women pregnant after assis ... | 2011 | 21565336 |
| halogenated phenolic contaminants inhibit the in vitro activity of the thyroid regulating deiodinases in human liver. | halogenated contaminants, particularly brominated flame retardants, disrupt circulating levels of thyroid hormones (th), potentially affecting growth and development. disruption may be mediated by impacts on deiodinase (di) activity, which regulate the levels of active hormones available to bind to nuclear receptors. the goal of this study was to develop a mass spectrometry based method for measuring the activity of dis in human liver microsomes and to examine the effect of halogenated phenolic ... | 2011 | 21565810 |
| the increased incidence of congenital hypothyroidism: fact or fancy? | objective: the incidence of congenital hypothyroidism (ch) detected by newborn screening in the us has increased significantly since the early 1990s. we defined the characteristics associated with the increased incidence. patients: a cohort of children with ch born during an earlier period of low incidence (1991-94) was compared with a cohort born during a later period when the incidence of ch had doubled (2001-04). measurements: screening was performed with t4 as the primary marker and tsh o ... | 2011 | 21623857 |
| neonatal hypothyroidism caused by maternal nicotine exposure is reversed by higher t3 transfer by milk after nicotine withdraw. | maternal nicotine exposure leads to neonatal hypothyroidism that can be returned to euthyroidism after nicotine withdrawal. here, we examined the transfer of iodine through milk, deiodinase activities (d1 and d2), and serum t3, t4 and tsh in rat offspring after maternal exposure to nicotine. one day after birth, a minipump was implanted to dams releasing nicotine (nic), 6mg/kg/day for 13days or vehicle saline. animals were killed at the day 15 and 21 of lactation. at day 15, nic-treated dams sho ... | 2011 | 21624425 |
| upregulation of mrna myocardium calcium handling in rats submitted to exercise and food restriction. | background: chronic exercise and food restriction (fr) have directionally opposite changes in transcription of molecular structures of calcium handling and thyroid hormone (th) status. objective: evaluate the association of chronic exercise and fr on serum thyroid hormones and gene transcription of molecular structures of intracellular calcium transients and thyroid receptors in myocardium of rats. methods: male wistar kyoto rats, divided into two groups: control (c, n = 7), fr (r50, n = 7), chr ... | 2011 | 21625820 |
| the hox gene network in hepatocellular carcinoma. | liver organogenesis and cancerogenesis share common mechanisms. hox genes control normal development, primary cellular processes and are characterized by a unique genomic network organization. less is known about the involvement of hox genes with liver cancerogenesis. the comparison of the hox gene network expression between nontumorous livers and hepatocellular carcinomas (hccs) highlights significant differences in the locus a hox genes, located on chromosome 7, with a consistent overexpressio ... | 2011 | 21626505 |
| purification of phage display-modified bacteriophage t4 by affinity chromatography. | abstract: background: affinity chromatography is one of the most efficient protein purification strategies. this technique comprises a one-step procedure with a purification level in the order of several thousand-fold, adaptable for various proteins, differentiated in their size, shape, charge, and other properties. the aim of this work was to verify the possibility of applying affinity chromatography in bacteriophage purification, with the perspective of therapeutic purposes. t4 is a large, ico ... | 2011 | 21627821 |
| beta blockers and breast cancer mortality: a population-based study. | purpose preclinical studies have demonstrated that antagonism of β(2)-adrenergic signaling inhibits several pathways necessary for breast tumor progression and metastasis. a series of population-based observational studies were conducted to examine associations between beta blocker use and breast tumor characteristics at diagnosis or breast cancer-specific mortality. patients and methods linked national cancer registry and prescription dispensing data were used to identify women with a diagnosis ... | 2011 | 21632503 |
| structure of the three n-terminal immunoglobulin domains of the highly immunogenic outer capsid protein from a t4-like bacteriophage. | the head of bacteriophage t4 is decorated with 155 copies of the highly antigenic outer capsid protein or hoc. one hoc molecule binds near the center of each hexameric capsomer. hoc is dispensable for capsid assembly and has been used to display pathogenic antigens on the t4 surface. here we report the crystal structure of a protein containing the first three of four domains of hoc from the bacteriophage rb49, a close relative of t4. the structure shows an approximately linear arrangement of the ... | 2011 | 21632759 |
| levothyroxine absorption in morbidly obese patients before and after roux-en-y gastric bypass (rygb) surgery. | background: roux-en-y gastric bypass (rygb) modifies the anatomical structure of the upper intestine tract, reduces gastric acid secretion, and may impair lt4 absorption. the aim of this study was to evaluate the lt4 absorption in morbidly obese patients before and after rygb. methods: thirty morbidly obese patients were divided in two groups: the ns group included 15 patients before rygb surgery (bmi = 43.1 ± 4 kg/m(2)), and the s group included 15 patients after surgery (bmi = 37.3 ± 4 kg/m(2) ... | 2011 | 21633823 |
| sentinel node biopsy should be offered in thin melanoma with mitotic rate greater than one. | background the american joint committee on cancer recently added mitotic rate (mr) to their seventh edition staging system for melanomas, which went into effect on january 1, 2010. mr has replaced the clark level of invasion for t1 melanomas. dermatologists and dermatopathologists should be aware of these new guidelines. objective to clarify how mr may be used to determine the prognosis of thin melanomas and to identify patients with thin melanomas who would be candidates for a sentinel lymph no ... | 2011 | 21635622 |
| alternative promoter usage and differential expression of multiple transcripts of mouse prkar1a gene. | prkar1a gene encodes regulatory type 1 alpha subunit (riα) of camp-dependent protein kinase (pka) in mouse. the role of this gene has been implicated in carney complex and many cancer types that suggest its involvement in physiological processes like cell cycle regulation, growth and/or proliferation. we have identified and sequenced partial cdna clones encoding four alternatively spliced transcripts of mouse prkar1a gene. these transcripts have alternate 5' utr structure which results from spli ... | 2011 | 21638026 |
| increased thyroidal t4 to t3 conversion in autonomously functioning thyroid adenoma: from euthyroidism to thyrotoxicosis. | aim: the aim was to investigate whether the intrathyroid conversion of t4 to t3 in autonomously functioning thyroid adenoma (afta) tissue could influence serum t3 levels and suppression of tsh, especially in patients with borderline thyroid function. patients and methods: in ten patients with afta, thyroidal conversion of t4 to t3 was investigated in nodular and paranodular, tsh-suppressed tissue. all patients had normal serum t4 and suppressed tsh. serum t3 was normal in six, and borderline or ... | 2011 | 21640977 |
| effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy. | background maternal hypothyroidism (oh and sch) during early pregnancy is suspected to associate with adverse obstetrical outcomes. aim the aim of the present study was to investigate whether maternal subclinical hypothyroidism during the early stage of pregnancy increase obstetrical complications and whether treatment results in an improvement in these outcomes. subjects and methods a total of 756 women in the first trimester (≤12 weeks) of pregnancy were enrolled through ten hospitals in sheny ... | 2011 | 21642766 |
| long-term response in advanced bladder cancer involving the use of temsirolimus and vinflunine after platin resistance. | relapse after initial first-line chemotherapy shows a poor prognosis in metastatic urothelial cancer. currently, several chemotherapeutic agents and targeted drugs are under evaluation for platin-resistant advanced urothelial carcinoma. vinflunine has been approved for second-line treatment in this indication. we present a patient with initial t4 advanced and subsequently metastasized bladder cancer, who has shown prolonged survival of 44 months after radical cystectomy. during her clinical cour ... | 2011 | 21642839 |
| interleukin-1{beta} (il-1{beta}) promotes susceptibility of toll-like receptor 5 (tlr5) deficient mice to colitis. | background the extent to which numerous strains of genetically engineered mice, including mice lacking toll-like receptor 5 (t5ko), display colitis is environment dependent. gut microbiota underlie much of the variation in phenotype. accordingly, embryonic rederivation of t5ko mice ameliorated their spontaneous colitis despite only partially correcting elevated proinflammatory gene expression. it was postulated that endogenous anti-inflammatory pathways mediated the absence of overt inflammation ... | 2011 | 21646247 |
| coordination of dna replication and recombination activities in the maintenance of genome stability. | across the evolutionary spectrum, living organisms depend on high-fidelity dna replication and recombination mechanisms to maintain genome stability and thus to avoid mutation and disease. the repair of severe lesions in the dna such as double-strand breaks or stalled replication forks requires the coordinated activities of both the homologous recombination and dna replication machineries. growing evidence indicates that so-called "accessory proteins" in both systems are essential for the effect ... | 2011 | 21647941 |
| [the effect of sevoflurane inhalation anesthesia only and propofol total intravenous anesthesia on perioperative cytokine balance in lung cancer patients]. | to investigate the effects of sevoflurane inhalation anesthesia only and propofol total intravenous anesthesia on perioperative cytokine balance in lung cancer patients. | 2011 | 21651869 |
| could thyroid dysfunction influence outcome in sunitinib-treated metastatic renal cell carcinoma? | background: sunitinib is a standard of care for metastatic renal cell carcinoma (mrcc). hypothyroidism is frequently observed under sunitinib therapy. this study was conducted to prospectively determine the correlation between thyroid function and progression-free survival (pfs) in this population. patients and methods: one hundred and eleven mrcc patients treated with sunitinib were evaluated for serum thyroid-stimulating hormone (tsh) and t4 levels before treatment and every 6 weeks during tre ... | 2011 | 21653681 |
| in ovo thyroxine exposure alters later uvs cone loss in juvenile rainbow trout. | thyroid hormones (ths) play a vital role in vertebrate neural development, and, together with the beta isoform of the thyroid hormone receptor (trβ), the development and differentiation of cone photoreceptors in the vertebrate retina. rainbow trout undergo a natural process of cone cell degeneration during development and this change in photoreceptor distribution is regulated by thyroxine (t4; a thyroid hormone). in an effort to further understand the role of t4 in photoreceptor ontogeny and lat ... | 2011 | 21653819 |
| minimum 5-year radiographic results of long scoliosis fusion in juvenile spinal muscular atrophy patients: major curve progression after instrumented fusion. | previous studies reported on spinal muscular atrophy (sma) scoliosis surgery outcomes without focus on major curve progression (mcp). the purpose of this study was to assess minimum 5-year radiographic outcomes, mcp, and factors for mcp after spinal surgery in juvenile sma patients with open triradiate cartilage at the time of surgery. | 2011 | 21654453 |
| effect of magnesium infusion on thoracic epidural analgesia. | patients of lung volume reduction surgery (lvrs) having an asa status iii or more are likely to be further downgraded by surgery to critical levels of pulmonary function. | 2011 | 21655018 |
| quick and clean cloning: a ligation-independent cloning strategy for selective cloning of specific pcr products from non-specific mixes. | we have developed an efficient strategy for cloning of pcr products that contain an unknown region flanked by a known sequence. as with ligation-independent cloning, the strategy is based on homology between sequences present in both the vector and the insert. however, in contrast to ligation-independent cloning, the cloning vector has homology with only one of the two primers used for amplification of the insert. the other side of the linearized cloning vector has homology with a sequence prese ... | 2011 | 21655102 |
| late onset pott's paraplegia in patients with upper thoracic sharp kyphosis. | purpose: the purpose of this study was to determine the clinical results of patients with late onset upper thoracic sharp pott's kyphosis and to predict the prognosis for pott's paraplegics. method: the study included five patients who developed late onset upper thoracic (t1-t4) sharp pott's kyphosis /kyphoscoliosis within a period from 19 to 37 years after the active disease was healed. the kyphosis angle of the patients ranged from 95° to 105°. among them, three patients suffered onset of para ... | 2011 | 21656306 |
| [hypothyroidism]. | hypothyroidism is one of the most frequent endocrine disorders affecting 4.6% of the adult population. 90% of the cases represent subclinical hypothyroidism, defined by increased serum tsh but normal free thyroxine (ft4) values. general screening for hypothyroidism is not recommended because of lack of benefits for the patients. search for hypothyroidism should therefore focus on patients with symptoms and signs and/or those presenting risk factors for development of hypothyroidism (e.g., autoim ... | 2011 | 21656490 |
| detection of 5-hydroxymethylcytosine in dna by transferring a keto-glucose by using t4 phage β-glucosyltransferase. | 2011 | 21656634 | |
| multivisceral resection for primary locally advanced rectal carcinoma. | pelvic multivisceral resection offers the possibility of cure in patients with locally advanced rectal cancer. this study assessed the clinical outcome and determinants of survival and local recurrence in patients undergoing multivisceral resection for clinical t4 primary rectal cancer. | 2011 | 21656723 |
| suppression of autophagy and activation of glycogen synthase kinase 3beta facilitate the aggregate formation of tau. | neurofibrillary tangle (nft) is a characteristic hallmark of alzheimer's disease. gsk3╬▓ has been reported to play a major role in the nft formation of tau. dysfunction of autophagy might facilitate the aggregate formation of tau. the present study examined the role of gsk3╬▓-mediated phosphorylation of tau species on their autophagic degradation. we transfected wild type tau (t4), caspase-3-cleaved tau at asp421 (t4c3), or pseudophosphorylated tau at ser396/ser404 (t4-2ec) in the presence of ac ... | 2011 | 21660151 |
| preoperative serum carbohydrate antigen 242 is a useful predictive and prognostic marker in colorectal cancer. | tumor markers (tm) play an important role in the management of colorectal cancer (crc). this study evaluates the predictive and prognostic value of preoperative serum carbohydrate antigen 242 (ca242) in crc. | 2011 | 21661399 |
| long-term survivors of esophageal carcinoma with distant lymph node metastasis. | clinical extra-regional lymph node metastasis, m1 lymph node metastasis (m1 lym), has been recognized as a far advanced condition in esophageal cancer. however, some patients with m1 lym survive long-term. the purpose of this study was to identify the clinicopathological features of those patients with m1 lym achieving long-term survival. | 2011 | 21661407 |
| mortality among men with locally advanced prostate cancer managed with noncurative intent: a nationwide study in pcbase sweden. | there are limited prognostic data for locally advanced prostate cancer pca to guide in the choice of treatment. | 2011 | 21664039 |
| pre-operative bevacizumab, capecitabine, oxaliplatin and radiation among patients with locally advanced or low rectal cancer: a phase ii trial. | background: to evaluate the safety and efficacy of pre-operative chemoradiation, using capecitabine, oxaliplatin and bevacizumab with standard doses of radiation, in patients with high-risk rectal cancer. methods: patients with locally advanced or low rectal cancer were treated with capecitabine 825mg/m(2) twice daily on days 1-14 and 22-35, oxaliplatin 50mg/m(2) on days 1, 8, 22 and 29, bevacizumab 5mg/kg on days 14, 1, 15 and 29, and radiation 50.4gy in 28 fractions including boost. total meso ... | 2011 | 21664123 |
| heterologous expression and purification of membrane-bound pyrophosphatases. | membrane-bound pyrophosphatases (m-ppases) are enzymes that couple the hydrolysis of inorganic pyrophosphate to pumping of protons or sodium ions. in plants and bacteria they are important for relieving stress caused by low energy levels during anoxia, drought, nutrient deficiency, cold and low light intensity. while they are completely absent in mammalians, they are key players in the survival of disease-causing protozoans making these proteins attractive pharmacological targets. in this work, ... | 2011 | 21664973 |
| efficacy of fluoro-2-deoxy-d-glucose positron emission tomography to evaluate responses to concurrent chemoradiotherapy for head and neck squamous cell carcinoma. | this study evaluates the utility of fluorodeoxyglucose-positron emission tomography (fdg-pet) in patients with head and neck squamous cell carcinoma (hnscc) who received concurrent chemoradiotherapy (ccrt). | 2011 | 21665394 |
| acute loading and aging effects on myostatin pathway biomarkers in human skeletal muscle after three sequential bouts of resistance exercise. | to determine the influence of age and resistance exercise on myostatin pathway-related genes, younger (n = 10; 28 -¦ 5 years) and older (n = 10; 68 -¦ 6 years) men underwent four testing conditions (t1-t4). a baseline (t1) muscle sample was obtained, whereas the second and third biopsies were obtained 48 hours following the first and second training sessions (t2, t3), and a final biopsy was taken 24 hours following t3. the training sessions consisted of 3 sets of 10 repetitions (80% of one repet ... | 2011 | 21665986 |
| phosphatase-like activity, dna binding, dna hydrolysis, anticancer and lactate dehydrogenase inhibition activity promoting by a new bis-phenanthroline dicopper(ii) complex. | a new bis-phenanthroline dicopper(ii) complex has been synthesized and characterized by elemental analysis and spectroscopic methods. the molecular structure of the dinuclear cu(ii) complex [cu(2)(╬╝-ch(3)coo)(╬╝-h(2)o)(╬╝-oh)(phen)(2)](2+) (phen = 1,10-phenanthroline) (1) was determined by single crystal x-ray diffraction technique. the coordination environment around each cu(ii) ion in complex 1 can be described as slightly distorted square pyramidal geometry. the distance between the cucu cen ... | 2011 | 21666926 |
| cationic phenylene ethynylene polymers and oligomers exhibit efficient antiviral activity. | the antiviral activities of poly(phenylene ethynylene) (ppe)-based cationic conjugated polyelectrolytes (cpe) and oligo-phenylene ethynylenes (ope) were investigated using two model viruses, the t4 and ms2 bacteriophages. under uv/visible light irradiation, significant antiviral activity was observed for all of the cpes and opes; without irradiation, most of these compounds exhibited high inactivation activity against the ms2 phage and moderate inactivation ability against the t4 phage. transmis ... | 2011 | 21667949 |