Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| high frequency of latent chlamydia trachomatis infection in patients with rhegmatogenous retinal detachment. | to determine the frequency of detection of ocular and extraocular chlamydia trachomatis (ct) infection in non-high myopes with rhegmatogenous retinal detachment (rrd). | 2016 | 27366689 |
| project gel a randomized rectal microbicide safety and acceptability study in young men and transgender women. | the purpose of project gel was to determine the safety and acceptability of rectal microbicides in young men who have sex with men (msm) and transgender women (tgw) at risk of hiv infection. | 2016 | 27362788 |
| evaluation of syndromic management guidelines for treatment of sexually transmitted infections in south african women. | to evaluate the performance of three different guidelines for the management of vaginal discharge syndrome (vds) for women living in a rural setting in south africa. | 2016 | 27350659 |
| a suspected case of lymphogranuloma venereum (lgv) suggests underdiagnosed lgv infection among slovenian men who have sex with men. | lymphogranuloma venereum (lgv) is sexually transmitted infection caused by serovars of chlamydia trachomatis, mostly seen among hiv-positive men who have sex with men. the first three reports of possible lgv in slovenia were from april to june 2015, followed by a confirmed case of lgv in august 2015. we present the case of an hiv-positive msm that presented with an anorectal abscess, discharge, lymphadenopathy, and unusual perianal plaque. gonococcal proctitis was assumed and he received empiric ... | 2016 | 27348456 |
| evaluation of chlamydia partner notification practices and use of the "let them know" website by family planning clinicians in australia: cross-sectional study. | chlamydia, caused by chlamydia trachomatis, is the most common reportable infection in many developed countries. testing, treatment, and partner notification (pn) are key strategies for chlamydia control. in 2008 the let them know (ltk) pn website was established, which provided means for people to send anonymous pn messages by text messaging (short message service, sms), email, or letter. | 2016 | 27342438 |
| fitz-hugh-curtis syndrome lacking typical characteristics of pelvic inflammatory disease. | a 23-year-old japanese woman, previously a commercial sex worker, presented with a 2-day history of right upper quadrant (ruq) abdominal pain, worse on deep inspiration. she had noticed increased vaginal discharge 2 months earlier and had developed dull, lower abdominal pain 3 weeks prior to presentation. although pelvic examination and transvaginal ultrasonography revealed neither a tubal nor ovarian pathology, abdominal ct scan with contrast demonstrated early enhancement of the hepatic capsul ... | 2016 | 27335367 |
| associations between sexually transmitted infections, high-risk human papillomavirus infection, and abnormal cervical pap smear results in ob/gyn outpatients. | this study aimed to examine the meaning and usefulness of sexually transmitted infection (sti) test when caring for patients who have abnormal cervical cytology and/or positive high-risk human papillomavirus (hpv) dna test results. | 2016 | 27329197 |
| immunization with chlamydial type iii secretion antigens reduces vaginal shedding and prevents fallopian tube pathology following live c. muridarum challenge. | chlamydia trachomatis infections in women are often asymptomatic and if left untreated can lead to significant late sequelae including pelvic inflammatory disease and tubal factor infertility. vaccine development efforts over the past three decades have been unproductive and there is no vaccine approved for use in humans. the existence of serologically distinct strains or serovars of c. trachomatis mandates a vaccine that will provide protection against multiple serovars. chlamydia spp. use a hi ... | 2016 | 27325352 |
| prevalence and antimicrobial resistance of mycoplasmas and chlamydiae in patients with genital tract infections in shanghai, china. | the infections of mycoplasmas and chlamydiae are still severe in patients with genital tract diseases and antimicrobial resistance for these organisms has been changing in recent years. in this study, we reported the prevalence status of ureaplasma urealyticum, mycoplasma hominis and chlamydia trachomatis in 965 patients with genital tract infection in shanghai from january 2011 to december 2014 and analyzed the antimicrobial resistance of u. urealyticum and m. hominis to 12 kinds of antimicrobi ... | 2016 | 27324895 |
| prevalence of curable sexually transmitted infections in pregnant women in low- and middle-income countries from 2010 to 2015: a systematic review. | current literature comparing the prevalence rates of curable sexually transmitted infections (stis) in pregnant women in various global regions is limited. as a result, antenatal screening practices for curable stis in pregnant women, specifically treponema pallidum (syphilis), neisseria gonorrhoeae (ng), chlamydia trachomatis (ct), and trichomonas vaginalis (tv) vary around the world, differing by country and particular sti. | 2016 | 27322048 |
| chlamydia trachomatis genital tract infections: when host immune response and the microbiome collide. | genital infections with chlamydia trachomatis continue to be a major health problem worldwide. while some individuals clear their infection (presumed to be the result of an effective th1/interferon-γ response), others develop chronic infections and some are prone to repeat infections. in females in particular, chronic asymptomatic infections are common and can lead to pelvic inflammatory disease and infertility. recent studies suggest that the genital tract microbiota could be a significant fact ... | 2016 | 27320172 |
| pre-exposure prophylaxis for hiv infection and new sexually transmitted infections among men who have sex with men. | we conducted a meta-analysis to summarize rates of sexually transmitted infections among men who have sex with men (msm) on pre-exposure prophylaxis (prep) for hiv versus msm not using prep. incidence rate ratios showed that msm using prep were 25.3 times more likely to acquire a neisseria gonorrhoeae infection, 11.2 times more likely to acquire a chlamydia trachomatis infection, and 44.6 times more likely to acquire a syphilis infection versus msm not using prep. | 2016 | 27314179 |
| differential frequency of nkg2c/klrc2 deletion in distinct african populations and susceptibility to trachoma: a new method for imputation of klrc2 genotypes from snp genotyping data. | nkg2c is an activating receptor that is preferentially expressed on natural killer (nk) cells. the gene encoding nkg2c (killer cell lectin-like receptor c2, klrc2) is present at different copy numbers in the genomes of different individuals. deletion at the nkg2c locus was investigated in a case-control study of 1522 individuals indigenous to east- and west-africa and the association with the ocular chlamydia trachomatis infection and its sequelae was explored. the frequency of homozygous klrc2 ... | 2016 | 27312142 |
| chlamydia antibody testing helps in identifying females with possible tubal factor infertility. | chlamydia is an important cause of sexually transmitted diseases leading to tubal factor infertility. | 2016 | 27294217 |
| the number, organization, and size of polymorphic membrane protein coding sequences as well as the most conserved pmp protein differ within and across chlamydia species. | variation is a central trait of the polymorphic membrane protein (pmp) family. the number of pmp coding sequences differs between chlamydia species, but it is unknown whether the number of pmp coding sequences is constant within a chlamydia species. the level of conservation of the pmp proteins has previously only been determined for chlamydia trachomatis. as different pmp proteins might be indispensible for the pathogenesis of different chlamydia species, this study investigated the conservatio ... | 2016 | 27463616 |
| [lymphoma of the conjunctiva with simultaneous infection with chlamydia trachomatis]. | 2016 | 27459516 | |
| nationwide surveillance of the antimicrobial susceptibility of chlamydia trachomatis from male urethritis in japan. | genital chlamydial infection is a principal sexually transmitted infection worldwide. chlamydia trachomatis can cause male urethritis, acute epididymitis, cervicitis, and pelvic inflammatory disease as sexually transmitted infections. fortunately, homotypic resistant c. trachomatis strains have not been isolated to date; however, several studies have reported the isolation of heterotypic resistant strains from patients. in this surveillance study, clinical urethral discharge specimens were colle ... | 2016 | 27452428 |
| the eclinical care pathway framework: a novel structure for creation of online complex clinical care pathways and its application in the management of sexually transmitted infections. | despite considerable international ehealth impetus, there is no guidance on the development of online clinical care pathways. advances in diagnostics now enable self-testing with home diagnosis, to which comprehensive online clinical care could be linked, facilitating completely self-directed, remote care. we describe a new framework for developing complex online clinical care pathways and its application to clinical management of people with genital chlamydia infection, the commonest sexually t ... | 2016 | 27448797 |
| lost opportunity to save newborn lives: variable national antenatal screening policies for neisseria gonorrhoeae and chlamydia trachomatis. | unfavorable pregnancy outcomes caused by chlamydia trachomatis or neisseria gonorrhoeae infection are well known. the first step in addressing antenatal c. trachomatis and n. gonorrhoeae infection is a national policy to screen all pregnant women for c. trachomatis and n. gonorrhoeae, regardless of symptoms. the aim of this study was to inform policy makers on the presence of antenatal screening recommendations for c. trachomatis and n. gonorrhoeae infection. we conducted a three-part study from ... | 2016 | 27440873 |
| chlamydia and ocular adnexal lymphomas: an indian experience. | an indian experience: ocular adnexal lymphomas (oals) are a heterogeneous group of malignancies, majority being extranodal mucosa-associated lymphoid tissue (malt) type. different geographical regions have reported association of chlamydia with oals (malt type). in india, role of chlamydia in oals remains unexplored. the aim of this study was to detect chlamydia and to correlate with clinicopathological features of oals in india. the clinicopathological features of 41 oal cases were studied pros ... | 2016 | 27435913 |
| prevalence of chlamydia trachomatis genotypes in men who have sex with men and men who have sex with women using multilocus vntr analysis-ompa typing in guangzhou, china. | chlamydia trachomatis is one of the most prevalent bacterial sexually transmitted infection in china. although c. trachomatis genotypes can be discriminated by outer membrane protein gene (ompa) sequencing, currently available methods have limited resolutions. this study used a high-resolution genotyping method, namely, multilocus variable number tandem-repeat analysis with ompa sequencing (mlva)-ompa, to investigate the local epidemiology of c. trachomatis infections among men who have sex with ... | 2016 | 27434536 |
| beyond tryptophan synthase: identification of genes that contribute to chlamydia trachomatis survival during gamma interferon-induced persistence and reactivation. | chlamydia trachomatis can enter a viable but nonculturable state in vitro termed persistence. a common feature of c. trachomatis persistence models is that reticulate bodies fail to divide and make few infectious progeny until the persistence-inducing stressor is removed. one model of persistence that has relevance to human disease involves tryptophan limitation mediated by the host enzyme indoleamine 2,3-dioxygenase, which converts l-tryptophan to n-formylkynurenine. genital c. trachomatis stra ... | 2016 | 27430273 |
| development and evaluation of a multi-antigen peptide elisa for the diagnosis of chlamydia trachomatis related infertility in women. | chlamydia trachomatis results in tubal factor infertility in some women. diagnosis of this tubal infertility is difficult and typically involves laparoscopy or hysterosalpingography to detect the tubal blockages. numerous serological tests have been developed however are presently not used for diagnosis without subsequent surgical during the infertility investigation. this study aimed to develop a highly specific serological assay for chlamydial tubal factor infertility in women that could be us ... | 2016 | 27430220 |
| etiology of genital ulcer disease in male patients attending a sexually transmitted diseases clinic: first assessment in cuba. | sexually transmitted diseases (stds) and in particular genital ulcer disease (gud) have a major impact on morbidity and mortality in developing countries. the world health organization recommends the use of syndromic guidelines for the treatment of sexually transmitted infections (stis) in resource-constrained countries. surveillance of autochthonous etiologies provides epidemiological information contributing to the prevention and treatment of stis. we investigated the etiology and factors asso ... | 2016 | 27419816 |
| does living outside of a major city impact on the timeliness of chlamydia treatment? a multicenter cross-sectional analysis. | timely treatment of chlamydia trachomatis infection reduces complications and onward transmission. we assessed client, process, and clinic factors associated with treatment delays at sexual health clinics in new south wales, australia. | 2016 | 27414683 |
| combination with antimicrobial peptide lyses improves loop-mediated isothermal amplification based method for chlamydia trachomatis detection directly in urine sample. | chlamydia trachomatis is an obligate intracellular human pathogen and is the most common cause of sexually transmitted diseases affecting both men and women. the pathogen can cause prostatitis and epididymitis in men. in women, cervicitis, pelvic inflammatory disease, ectopic pregnancy and acute or chronic pelvic pain are frequent complications. more than half of c. trachomatis-positive patients have minimal or no symptoms, providing an ongoing reservoir for the infection. the lack of sensitive ... | 2016 | 27412444 |
| approach to lymphogranuloma venereum. | to review the literature about lymphogranuloma venereum (lgv) and to provide an overview and discussion of practice guidelines. | 2016 | 27412206 |
| low prevalence of ocular chlamydia trachomatis infection and active trachoma in the western division of fiji. | trachoma is the leading infectious cause of blindness and is caused by ocular infection with the bacterium chlamydia trachomatis (ct). while the majority of the global disease burden is found in sub-saharan africa, the western pacific region has been identified as trachoma endemic. population surveys carried out throughout fiji have shown an abundance of both clinically active trachoma and trachomatous trichiasis in all divisions. this finding is at odds with the clinical experience of local hea ... | 2016 | 27404379 |
| prevalence and factors associated with coinfection of human papillomavirus and chlamydia trachomatis in adolescents and young women. | human papillomavirus and chlamydia trachomatis share the same route of sexual transmission and possess similar risk factors, indicating that coinfection may act synergistically in the induction of epithelial cell abnormalities. | 2016 | 27402054 |
| recombinant polymorphic membrane protein d in combination with a novel, second-generation lipid adjuvant protects against intra-vaginal chlamydia trachomatis infection in mice. | the development of a chlamydial vaccine that elicits protective mucosal immunity is of paramount importance in combatting the global spread of sexually transmitted chlamydia trachomatis (ct) infections. while the identification and prioritization of chlamydial antigens is a crucial prerequisite for efficacious vaccine design, it is likely that novel adjuvant development and selection will also play a pivotal role in the translational potential of preclinical ct vaccines. although the molecular n ... | 2016 | 27389169 |
| inhibitors of macrophage infectivity potentiator-like ppiases affect neisserial and chlamydial pathogenicity. | the pathogenic bacteria chlamydia trachomatis, neisseria gonorrhoeae and neisseria meningitidis express the surface-exposed macrophage infectivity potentiator (mip)-like protein, which plays a role in their pathogenicity. mip exhibits a peptidyl-prolyl isomerase (ppiase) activity that is inhibited by rapamycin and fk506. in this study, pipecolic acid derivatives were tested for their activity against the chlamydial and neisserial mip. two mip inhibitors were identified, pipn3 and pipn4, that aff ... | 2016 | 27516227 |
| [new approach in diagnostic algorithm of an infectious agents (parvovirus b19 and chlamydia trachomatis) involved in the development of pathological pregnancy]. | viral infections during pregnancy, along with some form of accompanying pregnancy diseases such as diabetes, cardiovascular, gastrointestinal, kidney and others, are a major cause of arising complications and mortality of mother and fetus. | 2016 | 27514136 |
| systematic review and meta-analysis of doxycycline efficacy for rectal lymphogranuloma venereum in men who have sex with men. | rectal lymphogranuloma venereum (lgv) has reemerged as a sexually transmitted infection among men who have sex with men (msm), particularly those who are hiv-positive. we undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal lgv in msm. nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. in total, 282 msm with rectal lgv were included in the studies. all studies reported ... | 2016 | 27513890 |
| a case of reactive arthritis associated with lymphogranuloma venereum infection in a woman. | we report the first case of reactive arthritis associated with lymphogranuloma venereum (lgv) in an italian human immunodeficiency virus-negative woman with urogenital and rectal chlamydia trachomatis l2 serovar infection. the lgv-associated arthritis has to be considered even when classic symptoms of arthritis are missing and in case of asymptomatic or cryptic lgv localizations. | 2016 | 27513386 |
| the prevalence of chlamydia trachomatis and mycoplasma genitalium tubal infections and their effects on the expression of il-6 and leukaemia inhibitory factor in fallopian tubes with and without an ectopic pregnancy. | this was a prospective case-control study that measured the prevalence of chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and mycoplasma genitalium (mg) by an ivd ce multiplex pcr kit in fresh fallopian tubes (ft) obtained from 96 ectopic pregnancies (ep) and 61 controls in the midluteal phase of the cycle. we later measured the expression profile of il-6, leukaemia inhibitory factor (lif) and their signalling molecules, in respect to the type and number of infections, by immunohistochemi ... | 2016 | 27511901 |
| polarized cell division of chlamydia trachomatis. | bacterial cell division predominantly occurs by a highly conserved process, termed binary fission, that requires the bacterial homologue of tubulin, ftsz. other mechanisms of bacterial cell division that are independent of ftsz are rare. although the obligate intracellular human pathogen chlamydia trachomatis, the leading bacterial cause of sexually transmitted infections and trachoma, lacks ftsz, it has been assumed to divide by binary fission. we show here that chlamydia divides by a polarized ... | 2016 | 27505160 |
| design of the femcure study: prospective multicentre study on the transmission of genital and extra-genital chlamydia trachomatis infections in women receiving routine care. | in women, anorectal infections with chlamydia trachomatis (ct) are about as common as genital ct, yet the anorectal site remains largely untested in routine care. anorectal ct frequently co-occurs with genital ct and may thus often be treated co-incidentally. nevertheless, post-treatment detection of ct at both anatomic sites has been demonstrated. it is unknown whether anorectal ct may play a role in post-treatment transmission. this study, called femcure, in women who receive routine treatment ... | 2016 | 27502928 |
| stat3-mediated tlr2/4 pathway upregulation in an ifn-gamma-induced chlamydia trachomatis persistent infection model. | inflammatory pathological injury caused by chlamydia trachomatis persistent infection could lead to a variety of urogenital tract diseases. by comparing the cytokine production and prr (pattern recognition receptor) expression between cell models with acute or persistent c. trachomatis infection, our data supported that persistent infection of c. trachomatis led to abnormal activation of toll-like receptor (tlr)2/4 signaling pathway and elevated il-1α and il-6 production, which was mediated by s ... | 2016 | 27502695 |
| mycoplasma genitalium macrolide resistance in stockholm, sweden. | mycoplasma genitalium is an important cause of sti in men and women. worldwide evidence suggests a reduction in efficacy of azithromycin treatment due to the prevalence of macrolide resistant m. genitalium. the aim of this study was to describe the prevalence of macrolide resistance in patients with a positive test for m. genitalium within our setting. | 2016 | 27502694 |
| [clinico-anamnestic diagnostics of chronic maxillary sinusitis associated with chlamydial infection]. | the present study included 201 adult patients presenting with exacerbation of chronic maxillary sinusitis. the presence of chlamydia trachomatis and chl. pneumoniae was verified by the direct immunofluorescencetechnique and polymerase chain reaction. the study material consisted of swipes und swabs from the mucous membrane of the middle nasal passage. the information from the patients was collected with the use of a questionnaire specially elaborated for the purpose of this study. the correlatio ... | 2016 | 27500582 |
| identification of a dominant chlamydia trachomatis strain in patients attending sexual transmitted infection clinic and female sex workers in tunisia using a high resolution typing method. | the distribution of chlamydia trachomatis genotypes in tunisia was previously studied using the reverse hybridization method. in this study, we used multilocus sequence typing (mlst) to describe chlamydia trachomatis genetic diversity among heterosexual populations in tunisia. the obtained sequence types (sts) were compared with those from a heterosexual population from amsterdam, the netherlands. | 2016 | 27497657 |
| performance of self-collected penile-meatal swabs compared to clinician-collected urethral swabs for the detection of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, and mycoplasma genitalium by nucleic acid amplification assays. | men were enrolled in a study to assess the performance and acceptability of self-collected penile meatal swabs as compared to clinician-collected urethral swabs for sexually transmitted infections (stis). we expected penile-meatal swabs to perform favorably to urethral swabs for chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), trichomonas vaginalis (tv), and mycoplasma genitalium (mg) detection by nucleic acid amplification assays (naats). of 203 swab pairs tested; for ct, penile-meatal s ... | 2016 | 27497595 |
| blinding trachoma: systematic review of rates and risk factors for progressive disease. | sight loss from trachoma is the end result of a scarring disease process starting in early childhood and characterised by repeated episodes of conjunctival inflammation (active trachoma). subsequently, the conjunctiva becomes scarred, causing the eyelashes to turn inwards and scratch the cornea (trichiasis), damaging the corneal surface and leading to corneal opacification and visual impairment. it is thought that this process is initiated and driven by repeated infection with chlamydia trachoma ... | 2016 | 27483002 |
| the incidence of sexually acquired reactive arthritis: a systematic literature review. | reactive arthritis (rea) is an inflammatory spondyloarthritis occurring after infection at a distant site. chlamydia trachomatis is proposed to be the most common cause of rea, yet the incidence of sexually acquired rea (sara) has not been well established. we therefore carried out a systematic literature review to collate and critically evaluate the published evidence regarding the incidence of sara. medline and embase databases were searched using free-text and mesh terms relating to infection ... | 2016 | 27480977 |
| sensing the enemy, containing the threat: cell-autonomous immunity to chlamydia trachomatis. | the bacterium chlamydia trachomatis is the etiological agent of the most common sexually transmitted infection in north america and europe. medical complications resulting from genital c. trachomatis infections arise predominantly in women where the initial infections often remain asymptomatic and thus unrecognized. untreated asymptomatic infections in women can ascend into the upper genital tract and establish persistence, ultimately resulting in extensive scarring of the reproductive organs, p ... | 2016 | 27476078 |
| impact of antiseptics on chlamydia trachomatis growth. | bacterial vaginosis is a frequent dysbiosis, where the normal lactobacillus-dominated flora is replaced by an anaerob/aerob polymicrobial flora. bacterial vaginosis increases the risk of acquiring sexually transmitted infections (sti) including the most frequent chlamydia trachomatis infections. intravaginal antiseptics are part of the bacterial vaginosis treatment, and ideally they should also inhibit the bacterial vaginosis-related sti. therefore, we tested the antichlamydial activity of four ... | 2016 | 27472980 |
| a probiotic adjuvant lactobacillus rhamnosus enhances specific immune responses after ocular mucosal immunization with chlamydial polymorphic membrane protein c. | recent advances in the development of chlamydia vaccines, using live-attenuated or ultraviolet light-inactivated chlamydia, are paving the way for new possibilities to oppose the societal challenges posed by chlamydia-related diseases, such as blinding trachoma. an effective subunit vaccine would mitigate the risks associated with the use of a whole-cell vaccine. our rationale for the design of an efficient subunit vaccine against chlamydia trachomatis (ct) is based on the membrane proteins invo ... | 2016 | 27636704 |
| implementation of oral and rectal gonococcal and chlamydial nucleic acid amplification-based testing as a component of local health department activities. | from january 1, 2014, to may 31, 2015, 452 individuals received extragenital nucleic acid amplification-based neisseria gonorrhoeae and chlamydia trachomatis testing through public health venues. seventy-four individuals (16%) tested positive for neisseria gonorrhoeae and/or chlamydia trachomatis at an extragenital site and 40 (54%) would not have been effectively diagnosed and treated in the absence of extragenital testing. | 2016 | 27631354 |
| azithromycin treatment failure for chlamydia trachomatis among heterosexual men with nongonococcal urethritis. | three recent prospective studies have suggested that the 1-g dose of azithromycin for chlamydia trachomatis (ct) was less effective than expected, reporting a wide range of treatment failure rates (5.8%-22.6%). reasons for the disparate results could be attributed to geographic or methodological differences. the purpose of this study was to reexamine the studies and attempt to harmonize methodologies to reduce misclassification as a result of false positives from early test-of-cure (toc) or rein ... | 2016 | 27631353 |
| the world health organization recommendations for trachoma surveillance, experience in nepal and added benefit of testing for antibodies to chlamydia trachomatis pgp3 protein: nests study. | the world health organization (who) now requires a second surveillance survey for trachoma after an impact assessment has found follicular trachoma (tf) <5% to determine if re-emergence has occurred. using new who guidelines, we undertook surveillance surveys, and determined the prevalence of infection and antibody positivity, in two districts in nepal. | 2016 | 27654497 |
| guinea pig genital tract lipidome reveals in vivo and in vitro regulation of phosphatidylcholine 16:0/18:1 and contribution to chlamydia trachomatis serovar d infectivity. | chlamydia trachomatis (ct), is the leading cause of sexually transmitted infections worldwide. host transcriptomic- or proteomic profiling studies have identified key molecules involved in establishment of ct infection or the generation of anti ct-immunity. however, the contribution of the host metabolome is not known. | 2016 | 27642272 |
| the role of serological testing for chlamydia trachomatis in differential diagnosis of pelvic pain. | pelvic pain is typically associated with pelvic inflammatory disease (pid). the most common cause of pid is chlamydia trachomatis. the aim of this study was to verify the role of serological testing for chlamydia trachomatis in patients with suspected pid. | 2016 | 27660878 |
| chlamydial protease-like activity factor and type iii secreted effectors cooperate in inhibition of p65 nuclear translocation. | the chlamydial protease-like activity factor (cpaf) is hypothesized to be an important secreted virulence factor; however, challenges in denaturing its proteolytic activity have hampered attempts to identify its legitimate targets. here, we use a genetic and proteomic approach to identify authentic cpaf targets. human epithelial cells infected with cpaf-sufficient and cpaf-deficient chlamydiae were lysed using known cpaf-denaturing conditions. their protein profiles were analyzed using isobaric ... | 2016 | 27677792 |
| otorhinolaryngology manifestations secondary to oral sex. | over the last few years, oral and pharyngeal signs and symptoms due to oral sex have increased significantly. however, no review articles related to this subject have been found in the medical literature. the objective of our study was to identify otorhinolaryngological manifestations associated with orogenital/oroanal contact, both in adults and children, in the context of consensual sex or sexual abuse. | 2016 | 27793330 |
| rectal infection with neisseria gonorrhoeae and chlamydia trachomatis in men in the united states. | centers for disease control and prevention guidelines recommend at least annual rectal screening of men who have receptive anal intercourse for neisseria gonorrhoeae (gc) and chlamydia trachomatis (ct). only limited national data are available on the prevalence of rectal gc and ct infection among us men. | 2016 | 27572098 |
| identification of chlamydia trachomatis antigens recognized by t cells from highly exposed women who limit or resist genital tract infection. | natural infection induces partial immunity to chlamydia trachomatis identification of chlamydial antigens that induce interferon γ (ifn-) secretion by t cells from immune women could advance vaccine development. | 2016 | 27738051 |
| erratum to: molecular characteristics of the ompa gene of serotype b chlamydia trachomatis in qinghai tibetan primary school students. | 2016 | 27734269 | |
| the making and taking of lipids: the role of bacterial lipid synthesis and the harnessing of host lipids in bacterial pathogenesis. | in order to survive environmental stressors, including those induced by growth in the human host, bacterial pathogens will adjust their membrane physiology accordingly. these physiological changes also include the use of host-derived lipids to alter their own membranes and feed central metabolic pathways. within the host, the pathogen is exposed to many stressful stimuli. a resulting adaptation is for pathogens to scavenge the host environment for readily available lipid sources. the pathogen ta ... | 2016 | 27720012 |
| examining chlamydia trachomatis and neisseria gonorrhoeae rates between 2010 and 2015: a population-based observational study. | bacterial sexually transmitted infections including chlamydia trachomatis and neisseria gonorrhoeae remain an important public health concern. we aimed to assess the population-based incidence of c. trachomatis and n. gonorrhoeae in an age-standardized cohort over time. a retrospective study of a large canadian health region was undertaken between 2010 and 2015 using linked census and digital laboratory data. c. trachomatis and n. gonorrhoeae tests were linked to patient data. sex and age-standa ... | 2016 | 27707952 |
| role and importance of chlamydia trachomatis in pregnant patients. | the aim of this study was to assess the prevalence of chlamydial infection among pregnant women and to determine the role of this infection in the fetus. | 2016 | 27703564 |
| under-reporting of sexually transmitted infection with chlamydia trachomatis - a revision of surveillance system is required. | to consider whether a revision of the national chlamydia surveillance system is needed, the objectives were to estimate the proportion of laboratory confirmed cases at the institute of microbiology and immunology (imi) not reported to the national institute of public health (niph), and to assess the completeness of reporting for individual data items. | 2016 | 27703536 |
| chlamydia screening and prophylactic treatment in termination of pregnancy clinics in the netherlands and great britain: a qualitative study. | women having a termination of pregnancy (top) have higher rates of chlamydia trachomatis (ct) than the general population. in this study, we explored ct treatment and prevention in dutch top clinics in comparison to that provided in great britain (gb). | 2016 | 27701927 |
| cell intrinsic factors modulate the effects of ifnγ on the development of chlamydia trachomatis. | chlamydia trachomatis is an obligate intracellular bacterial pathogen that cannot synthesize several amino acids, including tryptophan. rather, c. trachomatis acquires these essential metabolites from its human host cell. chlamydial dependence on host-provided tryptophan underlies a major host defense mechanism against the bacterium; namely, the induction of the host tryptophan-catabolizing enzyme, indoleamine 2,3- dioxygenase (ido1) by interferon gamma (ifnγ), which leads to eradication of c. t ... | 2016 | 27695641 |
| correction: low prevalence of conjunctival infection with chlamydia trachomatis in a treatment-naïve trachoma-endemic region of the solomon islands. | [this corrects the article doi: 10.1371/journal.pntd.0004863.]. | 2016 | 27695076 |
| screening pregnant women in the 2015 european guideline on the management of chlamydia trachomatis infections. | 2016 | 27694561 | |
| genotype-specific concordance of chlamydia trachomatis genital infection within heterosexual partnerships. | sexual transmission rates of chlamydia trachomatis (ct) cannot be measured directly; however, the study of concordance of ct infection in sexual partnerships (dyads) can help to illuminate factors influencing ct transmission. | 2016 | 27835626 |
| considerations for the rational design of a chlamydia vaccine. | chlamydia trachomatis is the leading cause of preventable blindness and the most common bacterial sexually transmitted infection. remarkable progress in vaccine research over the past six decades has led to the advancement of novel c. trachomatis vaccine candidates into clinical trials. however, many questions regarding the role of specific cellular populations and molecular mechanisms in protective immunity against human c. trachomatis genital tract infections remain unanswered. biomarkers of v ... | 2016 | 27835064 |
| trachoma: past, present and future. | to review the background, epidemiology and current management of trachoma in endemic areas and worldwide. | 2016 | 27830198 |
| surveillance and azithromycin treatment for newcomers and travelers evaluation (asante) trial: design and baseline characteristics. | immigrants and travelers may be sources of re-emergent infection in trachoma-endemic communities close to trachoma elimination. the primary objective of the a surveillance and azithromycin treatment for newcomers and travelers evaluation (asante) trial was to determine whether a newcomer and traveler surveillance and treatment program in addition to annual mass drug administration (mda) would reduce chlamydia trachomatis infection when compared to mda alone. | 2016 | 27820670 |
| [in poitou-charentes family planning centers, chlamydia trachomatis infection in women is more frequently detected through the presence or absence of risk factors than in accordance with official guidelines]. | the french health authorities recommend systematic screening for chlamydia trachomatis (ct) urogenital infections in dedicated sexual health centers (planning centers) for women under 25 years old and for women who have changed partners during the last year. the two main purposes of this study were to assess adherence to this recommendation in planning centers and to identify possible obstacles to this screening. | 2016 | 27817999 |
| association of bacterial vaginosis with chlamydia and gonorrhea among women in the u.s. army. | bacterial vaginosis (bv) is a common vaginal condition in women of reproductive age, which has been associated with chlamydia trachomatis and neisseria gonorrhoeae among commercial sex workers and women attending sexually transmitted infection clinics. pathogen-specific associations between bv and other sexually transmitted infections among u.s. military women have not been investigated. | 2016 | 27816380 |
| viability-pcr shows that naat detects a high proportion of dna from non-viable chlamydia trachomatis. | according to the current guidelines for laboratory diagnosis of sexually transmitted infections (stis), nucleic acid amplification tests (naats) are the preferred diagnostic method for chlamydia trachomatis (ct) infections. however, naats amplify the available target dna without discriminating between dna originating from viable or non-viable ct. assessing ct viability will provide more insights in the clinical and public health relevance of a ct positive test result. the aim of this study was t ... | 2016 | 27812208 |
| fitz-hugh-curtis syndrome: an incidental diagnostic finding in an infertility workup. | a case of fitz-hugh-curtis syndrome in a 32-year-old para 1+1 is reported. she presented with inability to conceive of 4 years duration. her husband's semen analysis was within normal range. she had a hysterosalpingogram that showed bilateral tubal blockage and clinical assessment showed right sided abdominal tenderness, cervical excitation tenderness, and adnexa tenderness. the endocervical swab test for chlamydia trachomatis was a positive. laparoscopy and dye test showed adhesion bands on the ... | 2016 | 27811461 |
| [surgical methods of abortion]. | a state of the art of surgical method of abortion focusing on safety and practical aspects. | 2016 | 27810130 |
| laryngopharyngeal reflux and herpes simplex virus type 2 are possible risk factors for adult-onset recurrent respiratory papillomatosis (prospective case-control study). | the human papillomavirus (hpv) causes recurrent respiratory papillomatosis (rrp). although hpv prevalence is high, the incidence of papillomatosis is low. thus, factors other than hpv infection probably contribute to rrp. this study investigated whether patients with papillomatosis are more often infected with herpes simplex virus type 2 and chlamydia trachomatis (cht) and whether laryngopharyngeal reflux (lpr) occurs in this group of patients more often. | 2016 | 27759910 |
| evaluation of patients with dry eye disease for conjunctival chlamydia trachomatis and ureaplasma urealyticum. | to determine the possibility of the development of dry eye disease (ded) as a result of persistent infection with chlamydia trachomatis and ureaplasma urealyticum in the conjunctiva of patients. | 2016 | 27803864 |
| severe proctitis caused by chlamydia trachomatis serovars d. | 2016 | 27803429 | |
| prevalence and genotyping of chlamydia trachomatis in symptomatic male patients from istanbul, turkey. | this study was conducted to determine the prevalence and distribution of urogenital chlamydia trachomatis genotypes in symptomatic male patients who were referred to the clinics of the istanbul faculty of medicine. of 419 urogenital swabs, 57 samples (13.6 %) were positive for c. trachomatis. genotype distribution of c. trachomatis-positive samples identified five genetic variants namely genotype e as the most prevalent (36.4 %), followed by genotype g (23.6 %), h (21.8 %), d (16.4 %) and f (1.8 ... | 2016 | 27795880 |
| quantitative protein profiling of chlamydia trachomatis growth forms reveals defense strategies against tryptophan starvation. | chlamydia trachomatis is one of the most common sexually transmitted bacterial pathogens in humans. the infection is often asymptomatic and can lead to chronic manifestations. the infectious elementary body and the replicating reticulate body are the two growth forms in the normal developmental cycle. under the influence of interferon-γ, the normal cycle is disrupted because of tryptophan degradation, leading to a third persistent form, the aberrant reticulate body.for the genital strain c. trac ... | 2016 | 27784728 |
| prevalence of chlamydia trachomatis infection in women, heterosexual men and msm visiting hiv counselling institutions in north rhine-westphalia, germany - should chlamydia testing be scaled up? | patients asking for a free anonymous hiv test may have contracted other sexually transmitted infections (stis) such as chlamydia trachomatis, yet chlamydia prevalence in that population is unknown. this study aimed to assess the prevalence and factors associated with chlamydia infection in patients seeking hiv testing at local public health authorities (lpha) in order to evaluate whether chlamydia testing should be routinely offered to them. | 2016 | 27784280 |
| [endometritis : rare disease with clinical importance?] | endometritis is nowadays rare in developed countries and typically shows a subclinical or mild course; therefore, there are probably more cases of endometritis than diagnosed but they lack clinical relevance. in the fertile period of life it can be the reason for vaginal bleeding and infertility. the most common causes for non-specific endometritis are residual placental tissue after abortion or childbirth, intrauterine interventions, lesions within the uterine cavity, such as endometrial polyps ... | 2016 | 27738813 |
| evaluation of screening for chlamydia trachomatis among young women in primary health care services in manaus, amazonas state, brazil. | screening for chlamydia trachomatis is not routinely offered to young asymptomatic women in brazil. this study evaluated the performance, usefulness, and operational suitability of the digene hybrid capture ii (hcii) ct-id dna-test as an opportunistic screening tool to detect c. trachomatis in the public health system in manaus, amazonas state. women aged 14-25 years who attended primary health care services were interviewed and one cervical specimen was collected during cytological screening. t ... | 2016 | 27783757 |
| the relationship between active trachoma and ocular chlamydia trachomatis infection before and after mass antibiotic treatment. | trachoma is a blinding disease, initiated in early childhood by repeated conjunctival infection with the obligate intracellular bacterium chlamydia trachomatis. the population prevalence of the clinical signs of active trachoma; ''follicular conjunctivitis" (tf) and/or ''intense papillary inflammation" (ti), guide programmatic decisions regarding the initiation and cessation of mass drug administration (mda). however, the persistence of tf following resolution of infection at both the individual ... | 2016 | 27783678 |
| sexual violence cases in a hospital setting in hong kong: victims' demographic, event characteristics, and management. | rainlily, the first one-stop crisis centre in hong kong, was set up in 2000 to protect female victims of sexual violence. this study aimed to analyse the characteristics of sexual assault cases and victims who presented to two hospitals in hong kong. the data are invaluable for health care professionals and policymakers to improve service provision to these victims. | 2016 | 27779096 |
| infection of epithelial cells with chlamydia trachomatis inhibits tnf-induced apoptosis at the level of receptor internalization while leaving non-apoptotic tnf-signalling intact. | chlamydia trachomatis is an obligate intracellular bacterial pathogen of medical importance. c. trachomatis develops inside a membranous vacuole in the cytosol of epithelial cells but manipulates the host cell in numerous ways. one prominent effect of chlamydial infection is the inhibition of apoptosis in the host cell, but molecular aspects of this inhibition are unclear. tumour necrosis factor (tnf) is a cytokine with important roles in immunity, which is produced by immune cells in chlamydial ... | 2016 | 27062399 |
| the duf582 proteins of chlamydia trachomatis bind to components of the escrt machinery, which is dispensable for bacterial growth in vitro. | chlamydiae are gram negative bacteria that develop exclusively inside eukaryotic host cells, within a membrane-bounded compartment. members of the family chlamydiaceae, such as chlamydia trachomatis, are pathogenic species infecting vertebrates. they have a very reduced genome and exploit the capacities of their host for their own development, mainly through the secretion of proteins tailored to interfere with eukaryotic processes, called effector proteins. all chlamydiaceae possess genes coding ... | 2016 | 27774439 |
| [chlamydia trachomatis]. | 2016 | 27773503 | |
| factors associated with the over-treatment and under-treatment of gonorrhea and chlamydia in adolescents presenting to a public hospital emergency department. | the purpose of this study was to measure the prevalence of chlamydia trachomatis (ct) and neisseria gonorrhoeae (gc) and the rates and factors associated with their over-treatment (ot) and under-treatment (ut). | 2016 | 27771470 |
| anogenital infection by chlamydia trachomatis and neisseria gonorrhoeae in hiv-infected men and women in salvador, brazil. | infections caused by chlamydia trachomatis and neisseria gonorrhoeae are the most common bacterial sexually transmitted infections throughout the world. these sexually transmitted infections are a growing problem in people living with hiv/aids. however, the presence of these agents in extra genital sites, remains poorly studied in our country. the objective of this study was to estimate the prevalence of chlamydia trachomatis and neisseria gonorrhoeae anal and genital infection in people living ... | 2016 | 27765581 |
| high chlamydia and gonorrhoea repeat positivity in remote aboriginal communities 2009?2011: longitudinal analysis of testing for re-infection at 3 months suggests the need for more frequent screening. | background: extremely high rates of diagnosis of chlamydia trachomatis (ct) and neisseria gonorrhoeae (ng) have been recorded in remote communities across northern and central australia. re-testing at 3 months, after treatment administered, of ct or ng is recommended to detect repeat infections and prevent morbidity and ongoing transmission. methods: baseline ct and ng laboratory data (2009-2010) from 65 remote health services participating in a cluster randomised trial was used to calculate the ... | 2016 | 27764650 |
| mathematical modelling of trachoma transmission, control and elimination. | the world health organization has targeted the elimination of blinding trachoma by the year 2020. to this end, the global elimination of blinding trachoma (get, 2020) alliance relies on a four-pronged approach, known as the safe strategy (s for trichiasis surgery; a for antibiotic treatment; f for facial cleanliness and e for environmental improvement). well-constructed and parameterized mathematical models provide useful tools that can be used in policy making and forecasting in order to help t ... | 2016 | 27756453 |
| chlamydia trachomatis infection and hpv/chlamydia trachomatis co-infection among hpv-vaccinated young women at the beginning of their sexual activity. | this study investigated the prevalence of chlamydia trachomatis infection, co-infection with human papillomavirus (hpv) and associated risk factors in a cohort of sexually active young women enrolled in an ongoing trial on hpv vaccination at the european institute of oncology (ieo, milan, italy). | 2016 | 27501926 |
| neutralizing antichlamydial activity of complement by chlamydia-secreted protease cpaf. | ascending infection by sexually transmitted chlamydia trachomatis is required for chlamydial induction of tubal pathology. to achieve ascension, the c. trachomatis organisms may have to spread from cell to cell, which inevitably exposes the organisms to extracellular mucosal effectors such as complement factors that are known to possess strong antichlamydial activities. here, we report that the chlamydia-secreted protease cpaf efficiently neutralized complement factor c3-dependent antichlamydial ... | 2016 | 27436813 |
| patients with cervical ureaplasma urealyticum and chlamydia trachomatis infection undergoing ivf/icsi-et: the need for new paradigm. | genital tract infections with ureaplasma urealyticum (uu) and chlamydia trachomatis (ct) are the most frequent sexually-transmitted disease worldwide. uu and ct infections are considered to be the leading cause for infertility and adverse pregnancy outcomes. however, little is known about the specific effect of cervical uu and ct infections on the etiology of female infertility, as well as the pregnancy outcomes of the patients undergoing in vitro fertilization/intracytoplasmic sperm injection-e ... | 2016 | 27752891 |
| designing and in silico analysis of porb protein from chlamydia trachomatis for developing a vaccine candidate. | bakground: chlamydia trachomatis is an obligate, intracellular, gram-negative bacterium that causes sexually transmitted infections. the outer membrane protein porb is a conserved chlamydial protein that functions as a porin and is a target for neutralizing antibodies (abs); thus, making it important for vaccine development. methods: we used an in silico strategy and homology modeling algorithms and focused on porb of c. trachomatis and explained its characterization with the help of bioinformat ... | 2016 | 27409330 |
| chlamydia peritonitis and ascites mimicking ovarian cancer. | background. pelvic inflammatory disease (pid) rarely results in diffuse ascites. severe adhesive disease secondary to pid may lead to the formation of inclusion cysts and even pelvic peritoneal nodularity due to postinflammatory scarring and cause an elevation of serum ca-125 levels. the constellation of these findings may mimic an ovarian neoplasm. case. we report a case of a 22-year-old female who presented with multiple pelvic cysts and diffuse ascites due to chlamydia trachomatis infection. ... | 2016 | 27747116 |
| current and future molecular diagnostics for ocular infectious diseases. | confirmation of ocular infections can pose great challenges to the clinician. a fundamental limitation is the small amounts of specimen that can be obtained from the eye. molecular diagnostics can circumvent this limitation and have been shown to be more sensitive than conventional culture. the purpose of this review is to describe new molecular methods and to discuss the applications of next-generation sequencing-based approaches in the diagnosis of ocular infections. | 2016 | 27585214 |
| abnormal expression of trail receptors in decidual tissue of chlamydia trachomatis-infected rats during early pregnancy loss. | chlamydia trachomatis is the scientific name of pathogenic bacteria causing infection that has been linked to spontaneous abortion. in this study, the expression pattern of tumor necrosis factor-related apoptosis-inducing ligand (trail; a cytokine related to cell apoptosis) and its receptors was monitored in the decidua of c trachomatis-infected pregnant rats during early gestation to investigate the potential role of this molecular system in c trachomatis-induced spontaneous abortion. the data ... | 2016 | 27852922 |
| water-filtered infrared a reduces chlamydial infectivity in vitro without causing ex vivo eye damage in pig and mouse models. | repeated ocular infections with chlamydia trachomatis trigger the development of trachoma, the most common cause of infectious blindness worldwide. water-filtered infrared a (wira) has shown positive effects on cultured cells and human skin. our aim was to evaluate the potential of wira as a possible non-chemical treatment for trachoma patients. we both modeled ocular chlamydial infections using c. trachomatis b to infect human conjunctival epithelial cells (hcje) and studied the effects of wira ... | 2016 | 27838487 |
| in vitro rescue of genital strains of chlamydia trachomatis from interferon-γ and tryptophan depletion with indole-positive, but not indole-negative prevotella spp. | the natural course of sexually transmitted infections caused by chlamydia trachomatis varies between individuals. in addition to parasite and host effects, the vaginal microbiota might play a key role in the outcome of c. trachomatis infections. interferon-gamma (ifn-γ), known for its anti-chlamydial properties, activates the expression of indoleamine 2,3-dioxygenase (ido1) in epithelial cells, an enzyme that catabolizes the amino acid l- tryptophan into n-formylkynurenine, depleting the host ce ... | 2016 | 27914477 |