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effects and mechanisms of total panax notoginseng saponins on proliferation of vascular smooth muscle cells with plasma pharmacology method.total panax notoginseng saponin (tpns) is extracted from panax notoginseng. our previous studies suggested that tpns could inhibit intimal hyperplasia. this study discussed the impact of tpns on the proliferation of vascular smooth muscle cells (vsmcs) and revealed the associated mechanisms through cell cycle-related factors and extracellular regulated protein kinase (erk) signal transduction pathway.201222150681
target separation of a new anti-tumor saponin and metabolic profiling of leaves of panax notoginseng by liquid chromatography with eletrospray ionization quadrupole time-of-flight mass spectrometry.a method coupling high-performance liquid chromatography (hplc) with quadrupole time-of-flight mass spectrometers (qtof-ms) using an eletrospray ionization (esi) source was firstly developed for detection, characterization and guiding target separation of variants of protopanaxdiol saponin from leaves of panax notoginseng. under the guidance of lc-qtof-ms, a new trace saponin was probed according to the precise elemental compositions of molecular ions and the fragmentation behavior, and then sep ...201222047761
transient receptor potential vanilloid-1 participates in the inhibitory effect of ginsenoside rg1 on capsaicin-induced interleukin-8 and prostaglandin e(2) production in hacat cells.objectives  ginsenoside rg1 (grg1), one of the major active constituents of panax notoginseng, has shown anti-inflammatory and antinocioceptic activity, but its role in keratinocytes needs further study. we have examined the inhibitory effect of grg1 on transient receptor potential vanilloid-1 (trpv1) activation in keratinocyte hacat cells and explored its involved mechanism. methods  hek 293t cells over-expressing exogenous trpv1 were constructed and named hek 293t-trpv1 cells. the effects of g ...201222221101
[effects of extracts from panax ginseng, panax notoginseng and ligusticum chuanxiong on expression of β-galactosidase and signal pathway p16-cyclin d/cdk-rb in vascular smooth muscle cells].to observe the pathological changes of vascular aging in spontaneously hypertensive rats (shrs), and the effects of extracts from panax ginseng, panax notoginseng (burk.) and ligusticum chuanxiong on vascular aging.201222237278
hormesis-based anti-aging products: a case study of a novel cosmetic.application of hormesis in aging research and interventions is becoming increasingly attractive and successful. the reason for this is the realization that mild stress-induced activation of one or more stress response (sr) pathways, and its consequent stimulation of repair mechanisms, is effective in reducing the age-related accumulation of molecular damage. for example, repeated heat stress-induced synthesis of heat shock proteins has been shown to have a variety of anti-aging effects on growth ...201223548988
[inhibitory effect of pns on drug metabolism enzyme cyp3a in rat livers and its kinetic analysis].to study the inhibitory effect of total saponins of the root and rhizome of panax notoginseng (pns) on drug metabolism enzyme cyp3a in rat livers and its kinetic analysis.201223373227
[systematic study on qams method for quality control of panax notoginseng].to establish a quantitative method of multi-components by single marker (qams) for determining ginsenoside rg1, rb1, rd, re and notoginsenoside r1 for the purpose of the quality control of panax notoginseng.201223373218
[effect on elimination of pyrogen and effectual components of panax notoginseng saponins by ultrafiltration membranes of different cut-off molecular weight and different materials].to study the elimination effect of bacterial endotoxins and the transmittance of panax notoginseng saponins by ultrafiltration membranes of different cut-off molecular weight and different materials.201122500435
analysis of the transcriptome of panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers.panax notoginseng (burk) f.h. chen is important medicinal plant of the araliacease family. triterpene saponins are the bioactive constituents in p. notoginseng. however, available genomic information regarding this plant is limited. moreover, details of triterpene saponin biosynthesis in the panax species are largely unknown.201122369100
[status and prospective on nutritional physiology and fertilization of panax notoginseng].sanqi, panax notoginseng, is a famous traditional chinese herb, which has more than 400 years cultivation history in china. this paper has reviewed the studies on the suitable growing soil conditions for sanqi, mineral nutrition effects on sanqi, and the effects of nutrients uptake on the yield and quality of sanqi by applying fertilizer. thereafter, research needed to be put further efforts in the future has raised for discussion, and outlined the following topics for further research like the ...201122242417
[study on the dynamic model with supercritical co2 fluid extracting the lipophilic components in panax notoginseng].to establish a dynamics model for extracting the lipophilic components in panax notoginseng with supercritical carbon dioxide (co2).201122233045
effects of panax notoginseng saponins on proliferation and differentiation of rat hippocampal neural stem cells.we aimed to investigate the effects of panax notoginseng saponins (pns) on proliferation, differentiation and self-renewal of rat hippocampal neural stem cells (nscs) in vitro. rat hippocampal nscs were isolated from post-natal day 1 (p1) rats and cultured in a serum-free medium. the neurospheres were identified by the expressions of nestin, class iii β-tublin (tuj-1) and glial fibrillary acid protein (gfap). the cells were given pns and subjected to oxygen glucose deprivation (ogd) as an in vit ...201121905288
Effects of panax notoginseng saponins on homing of C-kit+ bone mesenchymal stem cells to the infarction heart in rats.To investigate the effects of panax notoginseng saponins (PNS) on homing of C-kit+ bone mesenchymal stem cells (BMSCs) to the infarction heart.201121977864
comparative study on saponin fractions from panax notoginseng inhibiting inflammation-induced endothelial adhesion molecule expression and monocyte adhesion.abstract:201121995855
[colonization of arbuscular mycorrhizal fungi and dark septate endophytes in panax notoginseng].arbuscular mycorrhizal fungi (amf) and dark septate endophytes (dse) colonizing panax notoginseng in three main producing areas in wenshan prefecture of yunan province were investigated. the fungal colonization of 144 roots samples including healthy and rot roots of p. notoginseng with different age were observed by means of acid fuchsin stain. the results showed that p. notoginseng was the typical arbuscular mycorrhizal plant. although there was no significant difference in amf and dse coloniza ...201122121792
proteomic studies on protective effects of salvianolic acids, notoginsengnosides and combination of salvianolic acids and notoginsengnosides against cardiac ischemic-reperfusion injury.ethnopharmacological relevance: salvia miltiorrhiza and panax notoginseng are popularly used traditional chinese medicine for cardiovascular disorders and they are often used in the form of combination. however, mechanisms of their cardioprotective effects were still not clear. in the present study, the protective effects of salvianolic acids (sa), notoginsengnosides (ng) and combination of sa and ng (csn) against rat cardiac ischemia-reperfusion injury were checked and the protein expression pr ...201121903157
ginsenoside rb3 exerts antidepressant-like effects in several animal models.total ginsenosides have been shown to have therapeutic actions as antidepressants. we report a major active ingredient of total ginsenosides, the ginsenoside rb3 (rb3), which may have antidepressant-like effects. using the forced swim test, tail suspension test, and learned helplessness procedure, we found that rb3 had significant anti-immobility effects in mice in the forced swim and tail suspension tests and reduced the number of escape failures in the learned helplessness procedure. in a rese ...201121948936
best case series program supportive cases of cordyceps militaris- and panax notoginseng-based anticancer herbal formula.objective. the major aim of this study was to present 2 cancer cases treated with anticancer herbal formula panax notoginseng and cordyceps militaris.201121994206
[inhibition of glutathione-s-transferase by total saponins of panax notoginseng and its kinetics analysis in liver of mice].to study the inhibition of glutathione-s-transferase by total saponins of panax notoginseng and its kinetics analysis in liver of mice.201122121814
effects of panax notoginseng saponins on the activities of cyp1a2, cyp2c9, cyp2d6 and cyp3a4 in rats in vivo.the aim of this study was to assess the influence of the panax notoginseng saponins (pns) on the activities of the drug-metabolizing enzymes cytochrome p450 (cyp450) 1a2, 2 c9, 2d6 and 3a4 in rats. the activities of cyp1a2, 2 c9, 2d6 and 3a4 were measured using specific probe drugs. after pretreatment for 1 week with pns or physiological saline (control group), probe drugs caffeine (10 mg/kg; cyp1a2 activity), tolbutamide (15 mg/kg; cyp2c9 activity), metoprolol (20 mg/kg; cyp2d6 activity) and da ...201122162298
panax notoginseng saponins promote osteogenic differentiation of bone marrow stromal cells through the erk and p38 mapk signaling pathways.the chinese medicinal herb, panax notoginseng, has long been used to treat bone fractures and panax notoginseng saponins (pns) could promote bone formation. here, we investigated whether pns could promote osteogenesis of bone marrow stromal cells (bmscs) through modulating the mapk signaling pathways, which are implicated in bmsc osteogenesis. we found that pns markedly increased the mineralization of bmscs by alizarin red s assays and stimulate alkaline phosphatase activity of these cells. addi ...201121865745
panax notoginseng saponins inhibit zymosan a induced atherosclerosis by suppressing integrin expression, fak activation and nf-κb translocation.ethnopharmacological significance: panax notoginseng saponins (pns) are ingredients extracted from traditional chinese medicinal herb panax notoginseng. it has been demonstrated that pns have extensive effects on the cardiovascular system, including inhibition of platelet aggregation, increasing blood flow, improving left ventricular diastolic function in hypertensive patients and anti-inflammatory effect.201121924337
[In vivo distribution and pharmacokinetics of multiple effective components contained in Panax notoginseng saponins after intratympanic administration].To investigate in vivo distribution and pharmacokinetics of ginsenoside Rb1 (Rb1), ginsenoside Rg1 (Rg1 ) and sanchinoside R1 (R1) after intratympanic administration (IT) or intravenous administration (IV) of Panax notoginseng saponions (PNS) solution, and provide a novel route for delivering traditional Chinese medicine (TCM) to the brain.201122032151
[screening of plant pathogenic fungi by ginsenoside compound k production].to screen a new strain which can transform panaxadiol saponins into the rare ginsenoside compound k.201122007540
development and characterization of microsatellite markers for panax notoginseng (araliaceae), a chinese traditional herb.• premise of the study: microsatellite primers were developed for a chinese traditional herb, panax notoginseng, to investigate its genetic diversity and cultivar breeding. • methods and results: twelve polymorphic microsatellite loci were isolated from the microsatellite-enriched genomic library of p. notoginseng. the polymorphisms were assessed in two populations and an assemblage containing individuals from the whole distribution area. the number of alleles per locus ranged from three to 12, ...201121926312
prediagnostic methods for the hemolysis of herbal medicine injection.the xue-sai-tong injection, a traditional chinese medicine injection with total saponins extracted from sanchi ginseng, has been used for more than half a hundred years to treat coronary artery disease. the study is to establish a prediagnostic method for the hemolytic adverse effect of herbal medicine injection by taking xue-sai-tong injection as an example.201121963556
arsenic accumulation and resistance mechanism in panax notoginseng, a traditional rare medicinal herb.panax notoginseng, a traditional rare chinese medicinal herb, was recently found to bring health risk to consumers, mainly because soil in its major plantation area was contaminated by arsenic (as). we investigated the effect of soil as pollution on the growth and as uptake of pot-cultured p. notoginseng, and the associated mechanisms of as stressed response. results showed that, comparing with p. notoginseng growing in a low-as soil, the root, stem, and leaf biomasses of those growing in a high ...201122189375
Anticancer effects of 5-fluorouracil combined with warming and relieving cold phlegm formula on human breast cancer.OBJECTIVE: To investigate the anticancer effects of warming and relieving cold phlegm formula (, WRCP), a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng, and Gekko swinhonis G u enther, combined with 5-fluorouracil (5-FU) on human breast cancer in vivo. METHODS: Seventy-two Nu/Nu mice inoculated with MDA-MB-231 breast ...201122160948
herbal remedies supply a novel prospect for the treatment of atherosclerosis: a review of current mechanism studies.atherosclerosis (as) is a systemic cardiovascular disease with complicated pathogenesis involving oxidative stress, endothelial dysfunction and chronic inflammation. increasing lines of evidence have questioned the statins-dominated treatment for as, including their dangerous side-effects such as the breakdown of muscle when taken in larger doses. a multifaceted approach that addresses all major risk factors or pathological targets may provide an ideal treatment for as. studies of the herbal rem ...201121928391
anti-proliferative effects of raw and steamed extracts of panax notoginseng and its ginsenoside constituents on human liver cancer cells. 201121255464
saponin accumulation in the seedling root of panax notoginseng. 201121255468
isolation of four high-purity dammarane saponins from extract of panax notoginseng by centrifugal partition chromatography coupled with evaporative light scattering detection in one operation.centrifugal partition chromatography (cpc), as a continuous liquid-liquid partition chromatography with no solid support matrix, combined with evaporative light scattering detection (elsd) was employed for systematic separation and purification of weak-chromophoric saponins from a highly valued and important traditional chinese herbal medicine, panax notoginseng.201121259375
the antidepressant effects and mechanism of action of total saponins from the caudexes and leaves of panax notoginseng in animal models of depression.total saponins extracted from the caudexes and leaves of panax notoginseng (sclpn) have been used in the clinic for improving mental function, treating insomnia, and alleviating anxiety. the present study evaluated the potential antidepressant activity of sclpn in rodent models of depression and the mechanism of action of sclpn. mice were received sclpn at doses of 10-1000 mg/kg daily for 1, 7, and 14 days and then were subjected to the forced swim test and locomotor activity test. the results s ...201121273053
red notoginseng: higher ginsenoside content and stronger anticancer potential than asian and american ginseng.a systematic comparison of the ginsenosides and anticancer activities was performed among white (air-dried) and red (steamed) roots of notoginseng (ng, panax notoginseng), asian ginseng (ag, p. ginseng), and american ginseng (amg, p. quinquefolius). chemical profiles of different ginseng species were characterized, through simultaneous quantification of nineteen major ginsenosides, by hplc-uv at 202 nm. the antiproliferative and pro-apoptotic effects on human colorectal cancer cells were determi ...201121344064
chemical fingerprinting and quantitative analysis of a panax notoginseng preparation using hplc-uv and hplc-ms. 201121349173
panax notoginseng attenuates bleomycin-induced pulmonary fibrosis in mice.panax notoginseng (pn) is a traditional chinese herb experimentally proven to have anti-inflammatory effects, and it is used clinically for the treatment of atherosclerosis, cerebral infarction, and cerebral ischemia. this study aimed to determine the anti-inflammatory effects of pn against bleomycin-induced pulmonary fibrosis in mice. first, in an in vitro study, culture media containing lipopolysaccharide (lps) was used to stimulate macrophage cells (raw 264.7 cell line). tnf-a and il-6 levels ...201121423633
[effect of panax notoginseng saponins on autograft tendon healing in bone tunnel: interface histological characteristics].to investigate the effect of panax notoginseng saponins (pns) on tendon healing in bone tunnel.201121438325
screening of traditional chinese medicinal plants for quorum-sensing inhibitors activity.the misuse of antibiotics has contributed to widespread development of antimicrobial resistance among clinically significant bacterial species. alternative approaches other than those using antibiotics are needed in the fight against infectious diseases. quorum sensing (qs) is an intercellular signaling and gene regulatory mechanism, which is used by a number of opportunistic pathogenic bacteria in determining virulence gene expression. the study of qs may yield another strategy for disease cont ...201121439518
[breeding strains of panax notoginseng by using est-ssr markers].to comparatively determine the genetic variation and differentiation of different breeding strains of panax notoginseng for providing the basic information for genetic breeding.201121506401
in vitro studies of gynura divaricata (l.) dc extracts as inhibitors of key enzymes relevant for type 2 diabetes and hypertension.to evaluate traditionally used herb, gynura divaricata (l.) dc (bai bei san qi) as in vitro inhibitors of key enzymes involved in the pathogenesis of hyperglycemia and hypertension. we also determined the distribution of enzyme inhibitory activities in different aqueous and non-aqueous extracts.201121570455
effects of panax notoginseng saponins on proliferation and apoptosis of vascular smooth muscle cells.aim of the study: atherosclerosis is a common cardiovascular disease, and linked with the development of many cardiovascular complications, such as myocardial ischemia and stroke. although pathogenesis of atherosclerosis is not completely elucidated, increasing evidence has demonstrated that abnormal proliferation of vascular smooth muscle cells (vsmcs) plays an important role in formation of atherosclerosis. previous studies showed that saponins from panax notoginseng (pns) possess anti-atheros ...201121619919
panax notoginseng saponins inhibit ischemia-induced apoptosis by activating pi3k/akt pathway in cardiomyocytes.aim of this study: the panax notoginseng saponins (pns) have been clinically used for the treatment of cardiovascular diseases and stroke in china. evidences demonstrated that pns could protect cardiomyocytes from injury induced by ischemia, but the underlying molecular mechanisms of this protective effect are still unclear. this study was aimed to investigate the protective effect and potential molecular mechanisms of pns on apoptosis in h9c2 cells in vitro and rat myocardial ischemia injury mo ...201121619920
notoginsenoside st-4 inhibits virus penetration of herpes simplex virus in vitro.further study on steam-treated notoginseng, the roots of panax notoginseng (burk.) f.h. chen (araliaceae), which is a famous traditional chinese medicine that is used both in raw and treated forms for a long time, led to the isolation of a new dammarane-type saponin, namely notoginsenoside st-4. its structure was elucidated to be 3β,12β,20(s)-tri-hydroxydammar-24-ene-3-o-β-d-xylopyranosyl-(1 → 2)-β-d-glucopyranosyl-(1 → 2)-β-d-glu-copyranoside, based on the detailed analyses of the 1d and 2d nmr ...201121623512
induction of differentiation by panaxydol in human hepatocarcinoma smmc-7721 cells via camp and map kinase dependent mechanism.panaxydol (pnd) is one of the main non-peptidyl small molecules isolated from the lipophilic fractions of panax notoginseng. the present study was carried out to demonstrate the potential effects of panaxydol on the induction of differentiation of human liver carcinoma cell lines smmc-7721. cell viability was evaluated by mtt method and trypan blue exclusion assay respectively. the changes of morphology were detected by transmission electron microscope. inhibitors were applied to detect the sign ...201121628989
[accumulation of soil arsenic by panax notoginseng and its associated health risk].panax notoginseng is a valued traditional chinese medical herb. in this study, the arsenic (as) contamination of soil in p. notoginseng plantation area in wenshan (yunnan, china) was investigated; the absorption and accumulation of soil as by the p. notoginseng was revealed; and the associated health risk was evaluated. the results revealed that the soil as concentrations ranged between 6.9-242.0 mg x kg(-1). arsenic concentrations in 48% of the total soil samples were > 40 mg x kg(-1). the as c ...201121634192
pharmacokinetics study of bio-adhesive tablet of panax notoginseng saponins.panax notoginseng saponin (pns) is the main active gradient of chinese traditional medicine panax notoginseng. although its prominent therapeutic efficacy has been demonstrated by various researchers, the broader application is restricted by the low bioavailability of pns. this article aims to discuss pns's plasma pharmacokinetics after oral administration of bio-adhesive tablet of pns to beagle dogs and improve its bioavailability in comparison with normal tablet. the bio-adhesive tablet was pr ...201121658246
n-butanol extracts of panax notoginseng suppress lps-induced mmp-2 expression in periodontal ligament fibroblasts and inhibit osteoclastogenesis by suppressing mapk in lps-activated raw264.7 cells.objective: periodontitis is a group of inflammatory diseases that affect connective tissue attachments and the supporting bone that surround the teeth. osteoclasts are responsible for skeletal modeling and remodeling but may also destroy bone in several bone diseases, including osteoporosis and periodontitis. this study examined the anti-inflammatory effects of panax notoginseng (pn) on periodontal ligament fibroblasts (pdlfs) and raw264.7 cells under lipopolysaccharide (lps) induced inflammator ...201121703595
[effect of panax notoginseng saponins on app gene transcription in the brain tissue of samp8].to study the effect of panax notoginseng saponins (pns) on learning and memory ability and app gene transcription in the brain tissue in senescence accelerated mouse prone 8 (samp8).201121818973
induction of apoptosis in human promyelocytic leukemia hl60 cells by panaxynol and panaxydol.panaxynol and panaxydol are naturally occurring polyacetylenes, isolated from the lipophilic fractions of panax notoginseng, that exert anti-proliferative effects against malignant cells. however, to the best of our knowledge, no study concerning the inhibitory effects of the two polyacetylenes on cell growth of human promyelocytic leukemia cells has been reported. in this paper, we examined the antiproliferation and proapoptotic effects of panaxynol and panaxydol on hl60 cells and investigated ...201121716177
development and characterization of microsatellite markers for panax notoginseng (araliaceae), a chinese traditional herb.ôçópremise of the study: microsatellite primers were developed for a chinese traditional herb, panax notoginseng, to investigate its genetic diversity and cultivar breeding. ôçómethods and results: twelve polymorphic microsatellite loci were isolated from the microsatellite-enriched genomic library of panax notoginseng. the polymorphisms were assessed in two populations and an assemblage containing individuals from the entire distribution area. the number of alleles per locus ranged from 3 to 12 ...201121821584
trilinolein inhibits proliferation of human non-small cell lung carcinoma a549 through the modulation of pi3k/akt pathway.trilinolein has been identified as one of the active constituents isolated from panax notoginseng used widely in traditional chinese medicine. protective actions of panax notoginseng against cerebral ischemia, beneficial effects on the cardiovascular system, and hemostatic, antioxidant, hypolipidemic, hepatoprotective, renoprotective and estrogen-like activities have been illustrated. in the present study, the effects of trilinolein on the growth of non-small cell lung carcinoma a549 were invest ...201121721158
25-och3-ppd induces the apoptosis of activated t-hsc/cl-6 cells via c-flip-mediated nf-κb activation.25-och(3)-ppd is a dammarane-type triterpene sapogenin isolated from the roots, leaves and seeds of panax notoginseng, which has shown anti-tumor effects in several human cancer lines. in this study, we evaluated the effects of 25-och(3)-ppd on apoptosis of activated t-hsc/cl-6 cells induced by tumor necrosis factor-α (tnf-α). the inhibitory effects of eleven compounds isolated from panax ginseng and p. notoginseng were detected in activated t-hsc/cl-6 cells. 25-och(3)-ppd produced a significant ...201121924252
Inhibition of TLR Ligand- and Interferon Gamma-Induced Murine Microglial Activation by Panax Notoginseng.Among the many products which influence microglial activation and resulting neuroinflammation, herbal medicine has recently drawn much attention due to its immunomodulatory and neuroprotective activities. The purpose of the current study was to investigate the effects of an extract of Panax notoginseng (NotoG™) on TLR ligand- and IFN?-induced activation in N9 and EOC20 microglial cells lines. NotoG suppressed microglial activation as measured by reduced expression of accessory molecules (CD40 an ...201122183805
Ginsenoside-Rd potentiates apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells through the mitochondrial pathway.Our previous studies showed that ginsenoside-Rd, a purified component from Panax notoginseng, inhibited cell proliferation and reversed basilar artery remodeling. The aim of this study was to investigate whether ginsenoside- Rd influences H(2)O(2)-induced apoptosis in basilar artery smooth muscle cells (BASMCs). The results showed that ginsenoside-Rd significantly potentiated H(2)O(2)-induced cell death and cell apoptosis. This resulted in a concentration-dependent reduction of the cell viabilit ...201122076303
[in vitro balanced sustained-release of panax notoginseng saponins controlled with various matrix materials].to explore the influence of matrix materials in complicate ingredients on traditional chinese medicine and investigate the excipients selection model based on balanced release characteristics of multicomponents, the influence of hpmc (k4m, k15m, k100m) and carbomer (934p, 971p, 974p) was illustrated by testing in vitro release of ginsenoside-rg1, ginsenoside-rb1 and notoginsenoside-r1 in panax notoginseng saponins (model drug, pns). according to in vitro release results of pns matrix tablets in ...201021355219
[effects of combination of salvia miltiorrhiza and panax notoginseng on the pharmacokinetics of their major bioactive components in beagle dog].after oral administration of salvia miltiorrhiza (danshen in chinese), panax notoginseng (sanqi in chinese) and danshen sanqi combination suspensions to beagle dogs, the plasma concentration-time profiles of danshensu, tanshinone ii(a), cryptotanshinone, notoginsenoside r1, ginsenoside rg1 and rb1 were analyzed by lc-ms/ms. pharmacokinetic parameters were calculated and analyzed with bapp 2.0 software. the results showed that the cmax and auc of danshensu, notoginsenoside r1, ginsenoside rg1 and ...201021361045
protective effects of ginsenoside rb(3) on oxygen and glucose deprivation-induced ischemic injury in pc12 cells.to investigate the protective effects of ginsenoside rb(3), a triterpenoid saponin isolated from the leaves of panax notoginseng, on ischemic and reperfusion injury model of pc12 cells and elucidate the related mechanisms.201020140005
panax notoginseng saponins protect rabbit bone marrow stromal cells from hydrogen peroxide-induced apoptosis.to investigate the effects of panax notoginseng saponins (pnss) on hydrogen peroxide-induced apoptosis in rabbit bone marrow stromal cells (bmscs).201020141735
component analysis and free radical-scavenging potential of panax notoginseng and carthamus tinctorius extracts.panax notoginseng and carthamus tinctorius are known as traditional medicinal plants, and they also have edible values. to better understand their pharmacological mechanism, the present study assessed the in vitro antioxidant activities of extracts of p. notoginseng (epn) and c. tinctorius (ect). in addition, the main components of epn and ect were determined by hplc. the results show that epn mainly contained saponins, which were effective in scavenging (.)oh and o(.)(2-), while showing a low a ...201020151384
a flavonol glycoside, isolated from roots of panax notoginseng, reduces amyloid-beta-induced neurotoxicity in cultured neurons: signaling transduction and drug development for alzheimer's disease.a radix notoginseng flavonol glycoside (rnfg), quercetin 3-o-beta-d-xylopyranosyl-beta-d-galactopyranoside, was isolated from roots of panax notoginseng. among different biological properties tested, rnfg possessed a strong activity in preventing amyloid-beta (abeta)-induced cell death. in an in vitro assay, rnfg inhibited the aggregation of abeta in a dose-dependent manner. moreover, application of rnfg in cultured cortical neurons, or pc12 cells, reduced the abeta-induced cell death in time- a ...201020157237
ginsenoside-rg1 from panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats.panax notoginseng saponins have recently been reported to suppress liver fibrosis. since ginsenoside-rg1 is the most abundant component of p.notoginseng saponins, we investigated the effect of ginsenoside-rg1 on experimental liver fibrosis in rats. histological analysis revealed that ginsenoside-rg1 significantly improved the extent of liver fibrosis in rats induced by thioacetamide. ginsenoside-rg1 markedly suppressed the serum levels of fibrotic markers and hepatic hydroxyproline content in ra ...201020184879
oligonucleotide microarray with a minimal number of probes for the detection and identification of thirteen genera of plant viruses.a major challenge facing agriculture at present is the development of techniques that can screen field samples and other plant materials simultaneously for the presence of many viruses. microarray techniques show promise in this regard, as their high throughput nature can potentially detect a range of viruses using a single test. in this paper we present an array that can detect a wide spectrum of 169 plant virus species from 13 different genera. the array was constructed using an automated prob ...201020304013
dynamics of carbendazim residue in panax notoginseng and soil.to provide scientific information for gap of p. notoginseng and guiding the farmers and enterprises of chinese medicine, dynamics of carbendazim residue in the chinese medicinal herb, p. notoginseng and cultivated soil was studied at wenshan county in 2008. the half lives of carbendazim in p. notoginseng were 5.92-6.82 day (soil), 6.71-6.77 day (fresh leaf), 3.29-3.93 day (fresh root), and 31.50-36.67 day (powder of the dry root) separately. carbendazim residues in p. notoginseng were more stabl ...201020306171
simultaneous determination of three major bioactive saponins of panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study.panax notoginseng saponins (pns), the main active components of radix notoginseng, has been used for treating atherosclerosis, cerebral infarction, and cerebral ischemia. ginsenosides rg1, ginsenoside rb1, and notoginsenoside r1 are the main contributors of biological activities, determination of these three saponins is very important for the in vivo evaluation of pns. the present study aims to develop a liquid chromatography-tandem mass spectrometry (lc-ms/ms) method for the simultaneous quanti ...201020331853
alleviation of ovariectomy-induced osteoporosis in rats by panax notoginseng saponins.to examine the effects of panax notoginseng saponins (pns), the main active components of panax notoginseng, on ovariectomy-induced osteoporosis in rats. a total of 72 six-month-old female rats were randomly assigned to sham-operated group and five ovariectomized (ovx) groups: ovx with distilled water (5 ml/kg/day, p.o.), ovx with graded doses of pns (75, 150, 300 mg/kg/day, p.o.), and ovx with nilestriol (1 mg/kg/week, p.o.). animals were sacrificed after a 13-week treatment course. compared wi ...201020376572
panax notoginseng saponins promotes proliferation and osteogenic differentiation of rat bone marrow stromal cells.panax notoginseng saponins (pns) is the main effective component of panax notoginseng, have various pharmacologic activities such as antioxidant, anti-inflammatory, and estrogen-like bioactivities, have been shown to be an effective agent on anti-osteoporosis. bone marrow stromal cells (bmscs) play a crucial homeostatic role in skeletal modeling and remodeling due to their capability to differentiate into osteooblasts. whether pns has effect on osteogenic differentiation of bmscs are unknown. th ...201021167926
[effect of total saponins of panax notoginseng on urinary albumin in patients with chronic renal failure].to observe the curative effect of total saponins of panax notoginseng (pns) on chronic renal failure (crf).201021190603
panax notoginseng saponins potentiate osteogenesis of bone marrow stromal cells by modulating gap junction intercellular communication activities.the chinese medicinal herb, panax notoginseng, has long been used to treat bone fractures and panax notoginseng saponins (pns) could promote bone formation. we investigated the effects of pns on gap junction intercellular communication (gjic) and osteogenesis-associated genes in rat bone marrow stromal cells (bmscs).201021220939
[optimization of pns/tgco components effect on experimental qi stagnation and blood stasis type of coronary heart disease with increase-decrease baseline geometric proportion design method].preliminary exploration of panax notoginseng saponins (pns) and total saponins from cornus officinalis (tgco) components treatment and characteristics of qi stagnation and blood stasis type of coronary heart disease.201021243775
[physiologic characteristics of panax notoginseng seeds during after-ripening process].the studies were carried out on the physiologic characteristics of panax notoginseng seeds during the after--ripening process in order to understand the seed's biochemical and physiological changes and lay the foundation for the germplasm conversation and breeding research of p. notoginseng seeds.201021246811
ultra-high performance liquid chromatography/time-of-flight mass spectrometry (uhplc/tofms) for time-dependent profiling of raw and steamed panax notoginseng.the metabolic profiles of panax notoginseng and its associated therapeutic values are critically affected by the duration of steaming. the time-dependent steaming effect of p. notoginseng is not well-characterized and there is also no official guideline on its duration of steaming. in this paper, a uhplc/tofms-based metabolomic platform was developed for the qualitative profiling of multiparametric metabolic changes of raw p. notoginseng during the steaming process. our method was successful in ...201020079593
panaxatriol saponins extracted from panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity.thioredoxin-1 has various biologic activities, including the control of redox balance and the inhibition of apoptosis. the current study was designed to examine the effects of panaxatriol saponins (pts) extracted from panax notoginseng on thioredoxin-1 expression and 1-methyl-4-phenylpyridinium ion-induced injury.201019857566
effect of total saponins of "panax notoginseng root" on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats.the effect of total saponins of "panax notoginseng root" on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats201019748258
notoginsenoside r1 attenuates renal ischemia-reperfusion injury in rats.ischemia-reperfusion (i/r) injury of the kidney is a complex pathophysiological process and a major cause of acute renal failure. it has been shown that i/r injury is related to inflammatory responses and activation of apoptotic pathways. inhibition of certain elements of inflammatory responses and apoptotic pathway seemed to ameliorate renal i/r injury. as an effective element of panax notoginseng, nr1 has antioxidant, anti-inflammatory, antiapoptotic, and immune-stimulatory activities. therefo ...201020023602
anti-diabetic effects of panax notoginseng saponins and its major anti-hyperglycemic components.panax notoginseng (burk) f.h. chen (araliaceae) is a well-known and commonly used traditional chinese herb for treatment of various diseases, such as hemostasis, edema and odynolysis.201020435129
identification and molecular characterization of a new potyvirus from panax notoginseng.a potyvirus causing distortion and mosaic symptoms in the herbal plant sanqi (panax notoginseng) was isolated from yunnan province, china, and the complete nucleotide sequence of one isolate and the partial sequences of two other isolates were determined. the viral rna genome comprised 9,750 nt excluding the 3'-terminal poly(a) tail, with the capacity to encode a single polyprotein of 3,089 amino acids. phylogenetic analysis with other completely sequenced potyviruses revealed that the virus in ...201020446003
[effects of astragalosides and panax notoginseng saponins combination on oxidative stress of cerebral ischemic reperfusion injury in mice].to investigate the influence of astragalosides (ast) and panax notoginseng saponins (pns) combination on oxidative stress of brain tissues in c57bl/6 mice with cerebral ischemia-reperfusion injury.201020456843
the influence of sam-chil-geun (panax notoginseng) on the serum lipid levels and inflammations of rats with hyperlipidemia induced by poloxamer-407.atherosclerosis is characterized by the progressive deposition of lipids and inflammatory process. we attempted to develop a chemically-induced hyperlipidemic mice model, using poloxamer-407 and evaluated the lipid lowering and anti-inflammatory effect of p. notoginseng compared with that of atorvastatin, an antihyperlipidemic drug.201020499414
[effects of panax notoginseng saponins on ace2 and tnf-alpha in rats with post-myocardial infarction-ventricular remodeling].to research the effects of panax notoginseng saponins (pns) on angiotensin-converting enzymes 2 ( ace2) and tumor necrosis factor-alpha (tnf-alpha) in rats with post-myocardial infarction ventricular remodeling.201020518313
[effect of total saponins from rhizomes and flowers of panax notoginseng on tumor cell induced platelet aggregation].to investigate the effects of total saponins from rhizomes and flowers of panax notoginseng on tumor cell induced platelet aggregation (tcipa).201020518315
biotransformation of ginsenoside rb1 to ginsenoside rd by highly substrate-tolerant paecilomyces bainier 229-7.paecilomyces bainier 229-7 was obtained after uv irradiation for 8min in the presence of 0.4% licl and selection on potato dextrose media containing 30mg/ml saponin from panax notoginseng leaves (spnl). the mutant produces ginsenoside rd from ginsenoside rb1 with a bioconversion rate as high as 94.9% under optimized culture conditions in shake flasks when supplied with 20mg/ml of spnl. scale-up in 10-l fermenter resulted in an 89% bioconversion rate. ginsenoside rd was purified from the culture ...201020605716
[effect of intracoronary injection with xuesaitong in treating post-pci slow-reflow phenomenon in patients with st-segment elevation myocardial infarction].to evaluate the effect and safety of xuesaitong (xst, a panax notonginseng extract preparation) via intracoronary injection for treating post-pci slow-reflow phenomenon in patients with st-segment elevation myocardial infarction (stemi) and its impact on patients' prognosis.201020669666
antihepatocarcinoma activity of lactic acid bacteria fermented panax notoginseng.panax notoginseng was used as the medium for lactic acid bacteria fermentation to manufacture product with antihepatocarcinoma activity. the fermentation broth prepared in a 250 ml erlenmeyer flask was found to possess antiproliferation activity against hepatoma hep3b cells. at the dosage of 500 microg/ml, the viability of hepatoma hep3b cells was approximately 2.2%. when the fermentation was scaled up to a 6.6 l fermenter, it was found that the fermentation broth produced at 37 degrees c for 2 ...201020681639
panax notoginseng saponins attenuate atherogenesis accelerated by zymosan in rabbits.panax notoginseng saponins (pns) are highly valued traditional chinese medicine. the effects of pns (120 mg/kg, once daily administrated intragastrically (i.g.)) on atherosclerosis induced by a high-cholesterol diet and chronic inflammation, which was derived through zymosan (10 mg/kg, once every 2 d) administration intraperitoneally, were evaluated in rabbits for 8 weeks. a normal group, a simple high-fat diet group, and a zymosan plus high-cholesterol diet group (zym) were used as controls. ty ...201020686226
panax notoginseng saponins decrease cholesterol ester via up-regulating atp-binding cassette transporter a1 in foam cells.accumulating evidence has indicated that panax notoginseng saponins (pns), the major ingredients in panax notoginseng (burk.) f.h. chen which could be found widely in asia, can attenuate atherogenesis in vivo. this study was designed to examine the relationship of pns with cholesterol ester in foam cells sourced from macrophages and the effect of pns on the expression of atp-binding cassette transporter a1 (abca1).201020727959
[effects of panax notoginseng saponins on immune-neuroendocrine network of sd rats in experimental navigation and intensive exercise].the present study aims to study the influences experimental navigation and intensive exercise on immune-neuroendocrine network of the male rats and the effects of pns to this influence.201020815219
protective effect of panaxatriol saponins extracted from panax notoginseng against mptp-induced neurotoxicity in vivo.panaxatriol saponins (pts), the main constituents extracted from panax notoginseng, a chinese herbal medicine, has been shown to be an effective agent on various diseases. our previous study has demonstrated that pts is an inducer of thioredoxin-1 (trx-1) and has a possible potential as a therapeutic agent for parkinson's disease (pd). however, the effect of pts on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity in vivo is unknown.201020951784
anti-oxidative effects of the biennial flower of panax notoginseng against h2o2-induced cytotoxicity in cultured pc12 cells.abstract:201021029415
hypolipidemic and antioxidant activities of sanchi (radix notoginseng) in rats fed with a high fat diet.sanchi, also known as radix notoginseng, is a chinese traditional medicine prepared from roots of the herb panax notoginseng. sanchi is traditionally used as a hemostatic to control internal and external bleeding but also shows diverse bioactivities that include increasing coronary blood flow and reducing myocardial oxygen consumption and blood pressure. although research into the potential cardioprotective effects of sanchi is ongoing in the field of traditional chinese medicine, we sought to e ...201021036582
[action target of ginseng and panax notoginseng extracts on angiogenesis signaling pathway].to investigate the action targets of ginseng (gs) and panax notoginseng (pn), chinese herbs for benefiting qi and activating blood circulation, on angiogenesis signaling pathway (vegfr-2-ras-mapk) in human umbilical vein endothelial cells (huvec).201021038657
[influence of astragalosides and panax notoginseng saponins compatibility on mmp-9 and timp-1 after cerebral ischemia-reperfusion in mice].to investigate the effect of astragalosides (ast) and panax notoginseng saponins (pns) compatibility on the expression of matrix metalloproteinases-9 (mmp-9) and tissue inhibitor of metal11oproteinase-1 (timp-1) after cerebral ischemia/reperfusion (i/r) injury in mice, to probe into its anti-ischemic brain injury protection mechanism.201021046759
pharmacokinetics of panaxatrol disuccinate sodium, a novel anti-cancer drug from panax notoginseng, in healthy volunteers and patients with advanced solid tumors.to evaluate single-dose and multiple-dose pharmacokinetics of panaxatrol disuccinate sodium in healthy volunteers and patients with advanced solid tumors.201021052087
5,6-didehydroginsenosides from the roots of panax notoginseng.two minor novel dammarane-type saponins - 5,6-didehydroginsenoside rd (1) and 5,6-didehydroginsenoside rb1 (2) - were isolated from the dried roots of panax notoginseng along with sixteen known saponins. the structures of the new compounds were elucidated on the basis of spectroscopic and chemical methods.201021072027
simultaneous determination of three panax notoginseng saponins at sub-nanograms by lc-ms/ms in dog plasma for pharmacokinetics of compound danshen tablets.compound danshen tablets are composed of panax notoginseng, salvia miltiorrhiza and borneol. the tablets are prescribed for treatment of cardiovascular diseases in china. the present study aimed at developing a specific and sensitive lc-ms/ms method to simultaneously determine three bioactive p. notoginseng saponins, i.e., notoginsenoside r1, ginsenoside rg1 and rb1, in dogs after a single oral administration of the compound tablets in order to obtain the clinically relevant saponin-related phar ...201021081293
traditional herbal remedies that influence cell adhesion molecule activity.many traditional medicines have demonstrated immune activity, however, research has largely neglected their effects on cell adhesion molecules (cams). this review reports on extracts from 37 medicinal plant species, similar to or replicating traditional preparations, that up- or downregulate either gene or protein activity of cams. the majority of the investigations were in vitro, primarily of the immunoglobulin superfamily of cams, specifically intercellular cell adhesion molecule-1 (icam-1) an ...201021105177
protective effects and mechanism of panax notoginseng saponins on oxidative stress-induced damage and apoptosis of rabbit bone marrow stromal cells.to investigate the effects and possible mechanism of panax notoginseng saponins (pns) on oxidative stress-induced damage and apoptosis in bone marrow stromal cells (bmscs).201021110178
ginsenoside-rd, a purified component from panax notoginseng saponins, prevents atherosclerosis in apoe knockout mice.recently, it was revealed that the dysfunction of transmembrane ca(2+) transport, results in an increase in intracellular ca(2+)[ca(2+)](i), which is involved in the process of atherosclerosis. we previously demonstrated that ginsenoside-rd, a purified component from panax notoginseng, is a voltage-independent ca(2+) channels blocker. in this study, we investigated the effects of ginsenoside-rd on atherosclerosis and the underlying mechanisms in apolipoprotein e deficient (apoe(-/-)) mice and ra ...201021122802
[effect of panax notoginseng on genes expression of cyp and gst in liver tissues of rats].to examine the effects of panax notoginseng on the expression of cytochrome p450 (cyp) genes and glutathione s-trans-ferase (gst) genes in liver tissues of male sd rats.200920030096
panax notoginseng attenuates the infarct volume in rat ischemic brain and the inflammatory response of microglia.the roots of panax notoginseng (pn) are commonly used as a therapeutic agent to stop hemorrhage and as a tonic to promote health in traditional korean medicine. stroke triggers an inflammatory response that not only plays a central role in the pathogenesis of cerebral ischemia, but also induces secondary damage. this study was designed to investigate the neuroprotective effects of the methanol extract of pn on the infarct volume induced by middle cerebral artery occlusion (mcao) (90-min occlusio ...200919305121
[preparation and prescription of enteric coated pellets of panax notoginseng saponins pellets].to prepare enteric coated pellets containing panax notoginseng saponins.200919771862
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