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gorham-stout disease of the temporal bone involving the temporomandibular joint.gorham-stout disease of the skull is a very rare entity. it presents with gradual bone resorption, and proliferation of lymphoid and vascular channels within the bony matrix. this is often a diagnosis of exclusion confirmed with serial imaging and based on radiological evidence.201829363434
gorham disease.gorham disease, a rare condition of unknown etiology, presents as skeletal lucency on radiographs, prompting the classic eponym of vanishing bone disease. initial clinical presentation varies considerably but typically involves prolonged soreness in the affected region and, rarely, acute pathologic fracture. the nonspecific nature of complaints, lack of markers of systemic illness, and rarity of the disease contribute to delayed diagnosis. several imaging studies (eg, plain radiographs, computed ...201829309464
diagnosis and treatment of gorham-stout disease in maxillofacial regions.this study was aimed to investigate the clinical features, imaging examination, and treatment of the patients with gorham-stout disease (gsd) in maxillofacial region, so as to improve the understanding of gsd.201829309350
identification of candidate genes involved in the sugar metabolism and accumulation during pear fruit post-harvest ripening of 'red clapp's favorite' (pyrus communis l.) by transcriptome analysis.pear (pyrus spp.) is a popular fruit that is commercially cultivated in most temperate regions. in fruits, sugar metabolism and accumulation are important factors for fruit organoleptic quality. post-harvest ripening is a special feature of 'red clapp's favorite'.201828943832
generation of an infectious clone of amdv and identification of capsid residues essential for infectivity in cell culture.pathogenic strains of aleutian mink disease virus (amdv) such as utah-1 do not replicate in cell culture (e.g., crandell rees feline kidney cells) while the in vitro-adapted amdv strain adv-gorham (adv-g) is not pathogenic. here, we constructed a full-length infectious clone (padv-g). alignment of the vp2 gene of adv-g with that of other amdv strains revealed many amino acid (a.a.) residues conserved among pathogenic isolates that differed in adv-g. four virulence-associated, conserved residues ...201728923508
population growth of dysaphis pyri (hemiptera: aphididae) on different pear cultivars with discussion on curve fitting in life table studies.population growth parameters of the dysaphis pyri (boyer de fonscolombe) (hemiptera: aphididae) were evaluated on four different cultivars (coscia, ankara, williams, and santa-maria) of pear (pyrus communis l.) under field conditions in the van region of turkey. aphids were kept on leaves of 10-yr-old pear trees in plexiglas clip-cells (20 mm in diameter and 10 mm in height, with the upper side covered with muslin). for the description of the stage differentiation during population growth, we an ...201728854662
gorham-stout disease presenting as acute unilateral proptosis.gorham-stout disease (gsd) is a rare angiomatous disorder characterized by osteolysis. we report the case of a 66-year-old woman who developed sudden left eye proptosis and facial pain. neuroimaging demonstrated a destructive mass involving the roof and lateral wall of the left orbit with adjacent abnormal orbital soft tissue. an initial biopsy of the soft tissue was nondiagnostic; however, transcranial biopsy of the orbital roof revealed an intraosseous cavernous angioma, with infiltration of o ...201728837441
gorham-stout disease affecting the mandible: bone scintigraphy and computed tomography findings.we present images of a 13-year-old boy with gorham-stout disease affecting the mandible. initial bone scintigraphy showed poor visualization of tc-methylene diphosphonate (tc-mdp) uptake in the mandible body. however, abnormally increased tc-mdp uptake was noted in the bilateral mandibular rami. in the follow-up examination a year later, bone scintigraphy indicated that the disease had progressed to the bilateral mandibular rami with no uptake. in addition, massive osteolysis of the mandible was ...201728806245
mr imaging findings of vertebral involvement in gorham-stout disease, generalized lymphatic anomaly, and kaposiform lymphangiomatosis.to assess the mr imaging findings of vertebral involvement in gorham-stout disease (gsd), generalized lymphatic anomaly (gla), and kaposiform lymphangiomatosis (kla).201728795277
systematics of the ceracis furcifer species-group (coleoptera: ciidae): the specialized consumers of the blood-red bracket fungus pycnoporus sanguineus.the ceracis furcifer species-group (coleoptera: ciidae) originally comprised nine species names: ceracis cornifer (mellié, 1849); c. cylindricus (brèthes, 1922); c. furcifer mellié, 1849; c. hastifer (mellié, 1849); c. monocerus lawrence, 1967; c. ruficornis pic, 1916; c. simplicicornis (pic, 1916); c. semipallidus pic, 1922 and c. unicornis gorham, 1898. ceracis semipallidus was synonymised with c. furcifer and then no further changes were made to the composition of the group. here, we provide ...201728714939
a rare case of chylothorax. gorham-stout syndrome. 201728705386
a practical examination of rna isolation methods for european pear (pyrus communis).with the goal of identifying fast, reliable, and broadly applicable rna isolation methods in european pear fruit for downstream transcriptome analysis, we evaluated several commercially available kit-based rna isolation methods, plus our modified version of a published cetyl trimethyl ammonium bromide (ctab)-based method.201728662720
'bartlett' pear fruit (pyrus communis l.) ripening regulation by low temperatures involves genes associated with jasmonic acid, cold response, and transcription factors.low temperature (lt) treatments enhance ethylene production and ripening rate in the european pear (pyrus communis l.). however, the underlying molecular mechanisms are not well understood. this study aims to identify genes responsible for ripening enhancement by lt. to this end, the transcriptome of 'bartlett' pears treated with lt (0°c or 10°c for up to 14 d), which results in faster ripening, and control pears without conditioning treatment was analyzed. lt conditioned pears reached eating fi ...201728554478
[management of postoperative complications in cases of gorham's disease with cervical spine involvement: a case report].gorham's disease is a rare osteolytic bone disease, caused by pathological vascular tissue, which may spread to adjacent organs. it is a disease of unknown etiology, primarily involving the axial skeleton and whose treatment is not codified. cervical spine involvement is unusual. stabilization of the cervical spine is a real surgical challenge. we report the case of a young adult treated in our neurosurgery department for a cervical spine localization of gorham's disease.201728502565
expert's comment concerning grand rounds case entitled "thoracic osteotomy for gorham-stout disease of the spine: a case report and literature review" by c. maillot et al., eur spine j: doi 10.1007/s00586-014-3613-3. 201728500360
acoustic dissipation in wooden pipes of different species used in wind instrument making: an experimental study.in this study, the acoustic dissipation is investigated experimentally in wooden pipes of different species commonly used in woodwind instrument making: maple (acer pseudoplatanus), pear wood (pyrus communis l.), boxwood (buxus sempervirens), and african blackwood (dalbergia melanoxylon). the pipes are parallel to the grain, except one which forms an angle of 60° with the fiber direction. an experimental method, involving input impedance measurements with several lengths of air column, is introd ...201728464673
genotyping-by-sequencing of pear (pyrus spp.) accessions unravels novel patterns of genetic diversity and selection footprints.understanding of genetic diversity and marker-trait relationships in pears (pyrus spp.) forms an important part of gene conservation and cultivar breeding. accessions of asian and european pear species, and interspecific hybrids were planted in a common garden experiment. genotyping-by-sequencing (gbs) was used to genotype 214 accessions, which were also phenotyped for fruit quality traits. a combination of selection scans and association analyses were used to identify signatures of selection. p ...201728451438
a chylothorax of gorham disease treated by lymphatic embolization. 201728431649
transcriptome analysis reveals candidate genes related to color fading of 'red bartlett' (pyrus communis l.).the red color of fruit is an attractive plant trait for consumers. plants with color-faded fruit have a lower commercial value, such as 'red bartlett' pears (pyrus communis l.) that have dark-red fruit in the early stages of fruit development that subsequently fade to red-green at maturity. to identify the reason for color fading, we first analyzed the anthocyanin content of peel from 'red bartlett,' which displays the color fading phenomenon, and 'starkrimson,' which has no color fading. result ...201728408914
characterization and quantification of fruit phenolic compounds of european and tunisian pear cultivars.the flesh and peel of 19 pear cultivars (8 tunisian dessert cultivars, 8 european dessert cultivars and 3 french perry pear cultivars) were studied for their phenolic composition. phenolic compounds were identified by hplc/esi-ms2 and individually quantified by hplc-dad. five classes of polyphenols were present: flavan-3-ols, phenolic acids, flavonols, anthocyanins and simple phenolics (hydroquinones). the total phenolic content ranged between 0.1g/kg fresh weight (fw) ('conference' cultivar) an ...201728395820
from tooth extraction to gorham-stout disease: a case report.gorham-stout disease (gsd), or vanishing bone disease, is a very rare condition of unknown aetiology. it is characterised by progressive osteolysis and angiomatosis.201728384557
successful management of gorham-stout disease in the cervical spine by combined conservative and surgical treatments: a case report.gorham-stout disease (gsd) is a rare condition characterized by intraosseous proliferation of endothelial-lined vessels and progressive osteolysis. the precise etiology and pathophysiology of the disease remain poorly understood. current therapeutic options for gsd include chemotherapy, radiotherapy, and surgical resection, but the surgical treatment of gsd is difficult, especially in the spinal lesion. the indication of wide-margined resection was limited because of anatomical features. herein, ...201728367856
elicitors of host plant defenses partially suppress cacopsylla pyricola (hemiptera: psyllidae) populations under field conditions.defense elicitors are products that activate acquired defense responses in plants, thus rendering the plants less susceptible to attack by a broad range of pests. we demonstrated previously under laboratory conditions that foliar applications of the defense elicitors actigard (acibenzolar-s-methyl), employ (harpin protein), or odc (chitosan) to potted pear trees (pyrus communis l.) each caused an increase in mortality of cacopsylla pyricola (förster) (hemiptera: psyllidae) nymphs and altered the ...201728365771
optimization of edible coating formulations for improving postharvest quality and shelf life of pear fruit using response surface methodology.the effect of composite edible films containing soy protein isolate (spi) in combination with additives like hydroxypropyl methylcellulose (hpmc) and olive oil on 'babughosha' pear (pyrus communis l.) stored at ambient temperature (28 ± 5 °c and 60 ± 10% rh) was evaluated using response surface methodology (rsm). a total of 30 edible coating formulations comprising of spi (2-6%, w/v), olive oil (0.7-1.1%, v/v), hpmc (0.1-0.5%, w/v) and potassium sorbate (0-0.4% w/v) were evaluated for optimizing ...201728242897
vanishing bone disease of chest wall and spine with kyphoscoliosis and neurological deficit: a case report and review of literature.vanishing bone disease is an extremely rare disorder of unknown etiology characterized by idiopathic osteolysis of bone. we describe a case of vanishing bone disease of chest wall and spine with kyphoscoliosis and neurological deficit. a 17-year-old male presented with gradually progressive deformity of back and dorsal compressive myelopathy with nonambulatory power in lower limbs. radiographs revealed absent 4th-7th ribs on the right side with dorsal kyphoscoliosis and severe canal narrowing at ...201728216760
changes of pectin nanostructure and cell wall stiffness induced in vitro by pectinase.structural modifications of fruit cell-wall pectins are controlled by various enzymes. in this in vitro study, the cell wall material (cwm) from pear fruit (pyrus communis l.) was treated using pectinases in two concentrations. water soluble (wsp), chelator soluble (csp) and sodium carbonate soluble (dasp) pectin fractions were extracted from cwm. by visualization of enzymatic-induced changes of structure and cwm stiffness using an atomic force microscopy (afm), the role of pectins in the mechan ...201728189229
cellulose nanocrystal reinforced chitosan coatings for improving the storability of postharvest pears under both ambient and cold storages.cellulose nanocrystal (cnc, 0%, 5%, and 10% w/w, in chitosan, dry basis) reinforced 2% chitosan aqueous coatings were evaluated for delaying the ripening and quality deterioration of postharvest green d'anjou (pyrus communis l.) and bartlett (pyrus communis l.) pears during 3 wk of ambient storage (20 ± 2 °c and 30 ± 2% rh) or 5 mo of cold storage (-1.1 °c and 90% rh), respectively. ethylene and co2 production, color, firmness, and internal fruit quality were monitored during both storage condit ...201728146285
fourteen years follow-up of massive pelvic girdle osteolysis caused by lymphatic malformation (gorham-stout disease). 201728062382
lymphatic endothelial cells produce m-csf, causing massive bone loss in mice.gorham-stout disease (gsd) is a rare bone disorder characterized by aggressive osteolysis associated with lymphatic vessel invasion within bone marrow cavities. the etiology of gsd is not known, and there is no effective therapy or animal model for the disease. here, we investigated if lymphatic endothelial cells (lecs) affect osteoclasts (ocs) to cause a gsd osteolytic phenotype in mice. we examined the effect of a mouse lec line on osteoclastogenesis in co-cultures. lecs significantly increase ...201728052488
gorham-stout disease: a clinical case report and immunological mechanisms in bone erosion.gorham-stout disease (gsd) is a rare condition of osteolysis with excessive lymphangiogenesis within bone tissue. the etiology of this condition remains unknown but seems to affect mainly children and young adults of both genders all over the world. unfortunately, there is no standardized method for diagnosis; however, histopathology remains as the gold standard. this condition is often misdiagnosed due to its varying clinical presentations from case-to-case. here, we report the case of an 8-yea ...201728004375
characterization of tissue specific differences in cell wall polysaccharides of ripe and overripe pear fruit.cell walls from flesh, parenchyma cells, stone cells and skin were isolated from ripe and overripe pyrus communis l. cv "de cloche" using the phenol-buffer method. pear polysaccharides were solubilized from cell walls by sequential extractions with aqueous solutions of ammonium oxalate, na2co3, and increasing concentration of naoh, to explore overripening impact. cell walls were also differentiated using mir spectral data. stone cells contained high levels of xylose and lignin while parenchyma c ...201727842809
gorham disease: lymphangiomatosis with massive osteolysis.gorham disease (also referred to as vanishing bone disease or idiopathic massive osteolysis) is a rare skeletal condition that results in the localized replacement of bone with angiomas and fibrosis. the etiology and most effective treatment for this nonhereditary condition remain controversial in the medical literature. to our knowledge, we present the first case of post-traumatic gorham disease that includes mr imaging (before and after radiation therapy), post-radiation ct with evidence of tr ...201727829197
sirolimus in the treatment of vascular anomalies.aim of the study mtor inhibitors are showing promising results in the management of vascular anomalies. although current controlled trials remain to be completed, many individual experiences are being published. we present our series of children with complex vascular anomalies treated with sirolimus. patients and methods a retrospective review of 41 patients treated with sirolimus between january 2011 and december 2015 was performed: 15% (n = 6) had vascular tumors (4 kaposiform hemangioendothel ...201727723921
gorham-stout disease management during pregnancy.gorham-stout disease (gsd) is a rare lymphatic disorder affecting children or young adults with no predilection of sex. it is generally associated with vanishing bone osteolytic lesions, thoracic and abdominal involvement, and diffuse pulmonary lymphangiomatosis. chylous effusions and chylothorax, consequent to the abnormal proliferation of lymphatic vessels, may induce respiratory failure with a high mortality risk. extrapulmonary alterations may include chylous ascites, lymphopenia, and destru ...201729263942
two cases of gorham-stout disease with good response to zoledronic acid treatment.gorham-stout disease - also called vanishing bone syndrome - is a rare bone disease characterized by a progressive intra-osseous proliferation of non-neoplastic vascular tissue resulting in massive osteolysis. here, we report two clinical cases of gorham-stout disease. case 1: a 56-year-old woman with 20 years of history of pain and swell in elbows, ankles and wrist. then she was diagnosed as systemic lupus erythematosus (sle) with glomerulonephritis type iii. after other pathologies were ruled ...201729263745
systematics of the east palaearctic pear psyllids (hemiptera: psylloidea) with particular focus on the japanese and korean fauna.the confused taxonomy of the east palaearctic pear psyllids, serious pests on cultivated pear, is reviewed. fifty-six nominal species have been reported from pyrus, 25 of which we consider valid and ten as not being associated with pyrus. our taxonomic revision suggests that, in korea, four cacopsylla species develop on pear: the univoltine c. burckhardti luo et al. previously misidentified as c. pyrisuga (foerster), the polyvoltine, seasonally dimorphic c. jukyungi (kwon) (winter form 'cinereos ...201729245444
improvement of post-harvest quality of pear fruit with optimized composite edible coating formulations.application of edible coatings is a suitable method to maintain the quality and reduce post-harvest losses in fresh vegetables and fruits. pear fruits being climacteric have a short shelf life, and coating is considered as one of the most popular techniques to prolong its shelf life.the present study evaluates the effect of optimized edible coatings containing soy protein isolate (spi) in combination with additives like hydroxypropyl methylcellulose (hpmc) and olive oil on 'babughosha' pears (py ...201729085134
mandibular gorham-stout disease: a case report and literature review.gorham-stout disease (gsd) is characterized by aggressive bone resorption, proliferation of vascular or lymphatic vessels, and soft-tissue swelling. bones that initially appear normal start to resorb, partially or completely. however, the etiology of gsd is unknown.201729049202
vanishing act: gorham-stout disease leading to dynamic cerebrospinal fluid abnormalities. 201729016411
biology and epidemiology of venturia species affecting fruit crops: a review.the fungal genus venturia sacc. (anamorph fusicladium bonord.) includes plant pathogens that cause substantial economic damage to fruit crops worldwide. although venturia inaequalis is considered a model species in plant pathology, other venturia spp. also cause scab on other fruit trees. relative to the substantial research that has been conducted on v. inaequalis and apple scab, little research has been conducted on venturia spp. affecting other fruit trees. in this review, the main characteri ...201728974954
langerhans cell histiocytosis involving both jaws in an adult.langerhans cell histiocytosis (lch) is the latest terminology for a disorder of reticulo-endothelial system, previously known as histiocytosis x, and marked by aberrant proliferation of bone marrow derived langerhans cells with variable inflammatory infiltrate including neutrophils, lymphocytes, plasma cells, eosinophils, and multinucleated giant cells. although rare, the disorder frequently inflicts children with peak incidence recorded in 2-4 years age group. lch is rare in adults. a22-year ad ...201728969735
grafting on resistant interstocks reduces scion susceptibility to pear psylla, cacopsylla bidens.pear psylla is a major obstacle to efficient integrated pest management in pear orchards in israel and around the world. we used two accessions with natural resistance to pear psylla cacopsylla bidens (šulc) - py.760-261 (760) and py.701-202 (701), both apparently of pyrus communis l. origin - as interstock grafts to confer psylla resistance to the commercially important 'spadona estiva' (pyrus communis) scion (spadona) cultivar. the interaction of the interstocks with quince (cydonia oblong mil ...201728967187
gorham-stout disease: hand involvement in an 8-year-old child. 201728964427
comparative analysis of the predicted secretomes of rosaceae scab pathogens venturia inaequalis and v. pirina reveals expanded effector families and putative determinants of host range.fungal plant pathogens belonging to the genus venturia cause damaging scab diseases of members of the rosaceae. in terms of economic impact, the most important of these are v. inaequalis, which infects apple, and v. pirina, which is a pathogen of european pear. given that venturia fungi colonise the sub-cuticular space without penetrating plant cells, it is assumed that effectors that contribute to virulence and determination of host range will be secreted into this plant-pathogen interface. thu ...201728464870
patterns of low temperature induced accumulation of dehydrins in rosaceae crops-evidence for post-translational modification in apple.important crop plants of rosaceae family are often damaged during winter due to the lack of acclimation and cold hardiness. one of the cellular responses of plants to cold stress is the accumulation of dehydrin proteins. we studied the expression of dehydrins in several rosaceae species during low temperature treatment in vitro. microshoots of pyrus communis, malus×domestica, fragaria vesca, fragaria×ananassa, prunus cerasus and prunus avium cultivars were grown in low temperature conditions. ge ...201728886453
integrated high-density consensus genetic map of pyrus and anchoring of the 'bartlett' v1.0 (pyrus communis) genome.genetic maps are essential tools for pear genetics and genomics research. in this study, we first constructed an integrated simple sequence repeat (ssr) and single nucleotide polymorphism (snp)-based consensus genetic map for pear based on common ssr markers between nine published maps. a total of 5,085 markers, including 1,232 ssrs and 3,853 snps, were localized on a consensus map spanning 3,266.0 cm in total, with an average marker interval of 0.64 cm, which represents the highest density cons ...201728130382
validation of daily increment deposition and early growth of mud carp cirrhinus molitorella.in this study, laboratory reared cirrhinus molitorella from hatching through to the juvenile stage were used to validate daily increment deposition. lapilli were suitable for ageing c. molitorella. the slope of the linear relationships between increment counts and age was not significantly different from 1 (n = 258, p > 0·05), indicating that growth increments are deposited daily. the first increment following the first-feeding check formed 3 days post hatch (dph). one hundred and twenty-three j ...201728105739
low molecular weight chitosan is an effective antifungal agent against botryosphaeria sp. and preservative agent for pear (pyrus) fruits.antifungal activity and preservative effect of a low molecular weight chitosan (lmwc) sample, derived from chitosan by enzymatic hydrolysis, were investigated in vitro and in vivo. a pathogenic fungal strain was isolated from decayed pear (pyrus bretschneideri cv. "huangguan") fruit and identified as botryosphaeria sp. w-01. lmwc was shown to strongly inhibit w-01 growth based on studies of minimum inhibitory concentration (mic) and effects on mycelial biomass and radial growth of the fungus. lm ...201727818296
<i>neolinoptes</i> gen. n., a replacement name for the net-winged beetle genus <i>linoptes</i> gorham, 1884 and a new species of <i>lycomorphon</i> from guyana (coleoptera: lycidae).neolinoptes gen. n. is erected to replace linoptes gorham, 1884, preoccupied by linoptes menge, 1854 (arachnida: araneae). consequently, neolinoptes imbrex (gorham, 1884) comb. n., n. amazonicus (pic, 1923) comb. n., n. atronotatus (pic, 1922) comb. n., n. atripennis (pic, 1932) comb. n. are proposed. calocladon rubidum gorham, 1884 is transferred to neolinoptes. lycomorphon iwokrama sp. n. is proposed as new to science and the genus is recorded from guyana for the first time. additionally, fals ...201728183117
influence of the fiber from agro-industrial co-products as functional food ingredient on the acceptance, neophobia and sensory characteristics of cooked sausages.the sensory analysis of new products is essential for subsequent acceptance by consumers, moreover in the functional food market. the acceptance and food neophobia of cooked sausages formulated with cactus pear fiber or pineapple pear fiber, as functional ingredient, was complemented with a sensory characterization by r-index and qualitative descriptive analysis (qda). female consumers aged between 40 and 50 years showed greater interest in the consumption of healthy foods, with a higher level o ...201728242937
parathelohania iranica sp. nov. (microsporidia: amblyosporidae) infecting malaria mosquito anopheles superpictus (diptera: culicidae): ultrastructure and molecular characterization.microsporidia are common pathogens of insects and sometimes are considered as a candidate in the biological control of mosquitoes. recently a microsporidium infection was discovered in anopheles superpictus (diptera: culicidae) larvae, in iran. the responsible agent belonged to the genus parathelohania (microsporidia: amblyosporidae). this study has been carried out to identify its identity at the species level. fresh infected larvae were collected from the type locality, kiar district, in chaha ...201728372996
candidate pheromone receptors of codling moth cydia pomonella respond to pheromones and kairomones.olfaction plays a dominant role in the mate-finding and host selection behaviours of the codling moth (cydia pomonella), an important pest of apple, pear and walnut orchards worldwide. antennal transcriptome analysis revealed a number of abundantly expressed genes related to the moth olfactory system, including those encoding the olfactory receptors (ors) cpomor1, cpomor3 and cpomor6a, which belong to the pheromone receptor (pr) lineage, and the co-receptor (cpomorco). using heterologous express ...201728117454
comparative transcriptomic analysis reveals that ethylene/h2o2-mediated hypersensitive response and programmed cell death determine the compatible interaction of sand pear and alternaria alternata.a major restriction on sand pear (pyrus pyrifolia) production is black spot disease caused by the necrotrophic fungus alternaria alternata. however, the pear response mechanism to a. alternata is unknown at the molecular level. here, host responses of a resistant cultivar cuiguan (cg) and a susceptible cultivar sucui1 (sc1) to a. alternata infection were investigated. we found that the primary necrotic lesion formed at 1 dpi and the expansion of lesions was aggressive in sc1. data from transcrip ...201728261248
characterization of apple stem grooving virus and apple chlorotic leaf spot virus identified in a crab apple tree.apple stem grooving virus (asgv), apple chlorotic leaf spot virus (aclsv), and prunus necrotic ringspot virus (pnrsv) were identified in a crab apple tree by small rna deep sequencing. the complete genome sequence of aclsv isolate bj (aclsv-bj) was 7554 nucleotides and shared 67.0%-83.0% nucleotide sequence identity with other aclsv isolates. a phylogenetic tree based on the complete genome sequence of all available aclsv isolates showed that aclsv-bj clustered with the isolates sy01 from hawtho ...201727990565
efficient expression of an acidic endo-polygalacturonase from aspergillus niger and its application in juice production.an endo-polygalacturonase gene (pga-zj5a) was cloned by reverse transcription from cdnas synthesized from aspergillus niger zj5 total rna. the open reading frame of pga-zj5a was 1089 base pairs encoding 362 amino acids. pga-zj5a lacking a signal peptide sequence was successfully amplified using a. niger zj5 cdna as the template and was ligated into the ppic9 vector. the resulting plasmid was transformed into competent cells of pichia pastoris gs115 for heterologous expression. the polygalacturon ...201728248099
chemical variability, antioxidant and antifungal activities of essential oils and hydrosol extract of calendula arvensis l. from western algeria.the chemical composition of the essential oils and hydrosol extract from aerial parts of calendula arvensis l. was investigated using gc-fid and gc/ms. intra-species variations of the chemical compositions of essential oils from 18 algerian sample locations were investigated using statistical analysis. chemical analysis allowed the identification of fifty-three compounds amounting to 92.3-98.5% with yields varied of 0.09-0.36% and the main compounds were zingiberenol 1 (8.7-29.8%), eremoligenol ...201728109063
the prevalence and impact of babesia canis and theileria sp. in free-ranging grey wolf (canis lupus) populations in croatia.babesia spp. and theileria spp. are important emerging causes of disease in dogs. alongside these domesticated hosts, there is increasing recognition that these piroplasms can also be found in a range of wild animals with isolated reports describing the presence of these pathogen in foxes (vulpes vulpes) and captive grey wolves (canis lupus). the prevalence and impact of these infections in free-ranging populations of canids are unknown. to gain a better insight into the epidemiology and pathoge ...201728376903
fermentation of dietetic fiber from green bean and prickly pear shell by pure and mixture culture of lactobacillus acidophilus la-5 and bifidobacterium bifidum 450b.the aim of this study was to evaluate the fermentation of dietary fiber from green bean (phaseolus vulgaris) and prickly pear shell (opuntia ficus-indica) by lactobacillus acidophilus la-5 and bifidobacterium bifidum 450b growing as mono-culture and co-culture, the fermentation products, and proteins expressed during this process. the analysis of the fermentation profile showed a major growth of bacteria in the culture media of each dietary fiber supplemented with glucose, and particularly b. bi ...201728332163
evaluation of food lures for capture and monitoring of anastrepha fraterculus (diptera: tephritidae) on temperate fruit trees.the anastrepha fraterculus (wiedemann) (diptera: tephritidae) is the main pest of fruit trees grown in temperate climates in the southern region of brazil. the objective of this work was to evaluate the efficiency of the major commercial food lures used in brazil for trapping and monitoring of a. fraterculus in plum, pear, and feijoa orchards. the assessed lures were hydrolyzed proteins of animal origin (ceratrap) and plant origin (bioanastrepha), torula yeast + borax (torula), and grape juice. ...201728334322
whole-genome sequence of pseudomonas fluorescens ek007-rg4, a promising biocontrol agent against a broad range of bacteria, including the fire blight bacterium erwinia amylovora.here, we report the first draft whole-genome sequence of pseudomonas fluorescens strain ek007-rg4, which was isolated from the phylloplane of a pear tree. p. fluorescens ek007-rg4 displays strong antagonism against erwinia amylovora, the causal agent for fire blight disease, in addition to several other pathogenic and non-pathogenic bacteria.201728360179
molecular cloning and heterologous expression analysis of jrvte1 gene from walnut (juglans regia).tocopherol cyclase (vte1) plays a key role in promoting the production of γ-tocopherol and improving total tocopherol content in photosynthetic organisms. walnut is an important source of tocopherols in the human diet, and γ-tocopherol is the major tocopherol compound in walnut kernels. in this study, a full-length cdna of the vte1 gene was isolated from walnut using rt-pcr and race, and designated as jrvte1. the full-length cdna of the jrvte1 gene contained a 1353-bp open-reading frame encoding ...201726612974
exposure to minimally processed pear and melon during shelf life could modify the pathogenic potential of listeria monocytogenes.survival and virulence of foodborne pathogens can be influenced by environmental factors such as the intrinsic properties of food as well as the extrinsic properties that contribute to food shelf life (e.g., temperature and gas atmosphere). the direct contribution of food matrix characteristics on the survival of l. monocytogenes during fresh-cut fruit shelf life is not very well understood. in addition, the gastrointestinal tract is the primary route of listeriosis infection and penetration of ...201727889159
viable bacterial population and persistence of foodborne pathogens on the pear carpoplane.knowledge on the culturable bacteria and foodborne pathogen presence on pears is important for understanding the impact of postharvest practices on food safety assurance. pear fruit bacteria were investigated from the point of harvest, following chlorine drenching and after controlled atmosphere (ca) storage to assess the impact on natural bacterial populations and potential foodborne pathogens.201727300139
pcppi: a comprehensive database for the prediction of penicillium-crop protein-protein interactions.penicillium expansum , the causal agent of blue mold, is one of the most prevalent post-harvest pathogens, infecting a wide range of crops after harvest. in response, crops have evolved various defense systems to protect themselves against this and other pathogens. penicillium -crop interaction is a multifaceted process and mediated by pathogen- and host-derived proteins. identification and characterization of the inter-species protein-protein interactions (ppis) are fundamental to elucidating t ...201728365721
comparison of the effects of three types of aminobutyric acids on the control of penicillium expansum infection in pear fruit.aminobutyric acids were reported to have inhibitory effects on postharvest fungal diseases. the effects of α-aminobutyric acid (aaba), β-aminobutyric acid (baba) and γ-aminobutyric acid (gaba) on the control of penicillium expansum infection in pear fruit were compared in the present study.201727392194
transcriptome analysis of bagging-treated red chinese sand pear peels reveals light-responsive pathway functions in anthocyanin accumulation.bagging is an efficient method to improve fruit colour development. this work reported a transcriptome analysis using bagging-treated red chinese sand pear peels. in total, 8,870 differentially expressed genes were further analysed by a weighted gene co-expression network analysis and early-, middle- and late light-responsive genes were identified. an annotation analysis revealed several pathways involved in the different responsive stages. the presence of long hypocotly 5, cry-dash and a consta ...201728246400
extracts from two ubiquitous mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies.a signature feature of age-related neurodegenerative proteinopathies is the misfolding and aggregation of proteins, typically amyloid-β (aβ) in alzheimer's disease (ad) and α-synuclein (α-syn) in parkinson's disease (pd), into soluble oligomeric structures that are highly neurotoxic. cellular and animal models that faithfully replicate the hallmark features of these disorders are being increasing exploited to identify disease-modifying compounds. natural compounds have been identified as a usefu ...201727919712
increased intracranial pressure in a boy with gorham-stout disease.gorham-stout disease (gsd), also known as vanishing bone disease, is a rare disorder, which most commonly presents in children and young adults and is characterized by an excessive proliferation of lymphangiomatous tissue within the bones. this lymphangiomatous proliferation often affects the cranium and, due to the proximate location to the dura surrounding cerebrospinal fluid (csf) spaces, can result in csf leaks manifesting as intracranial hypotension with clinical symptoms to include orthost ...201727194986
gorham's disease: clinical case.gorham's disease, also known as idiopathic massive osteolysis, is a rare pathological condition characterized by vascular proliferation that results in destruction and reabsorption of the bone matrix, of unknown etiology. it was first described by jackson in 1838, but it was gorham and stout, in 1955, who defined this disease as a specific entity. it has variable clinical presentation and generally has progressive behavior. controversy continues regarding the treatment and there is no standard t ...201726229923
gorham-stout syndrome: phantom bone disease.gorham-stout syndrome is a disease that presents idiopathic osteolysis of a bone or closely contiguous area. the etiology is unknown. it is a rare condition that is difficult to diagnose, and its treatment is controversial. it affects individuals irrespective of age or sex. in this study, we conducted a bibliographic review of the disease, specifically focusing on the differential diagnosis, and we demonstrated the follow-up on a patient with this syndrome from the time of its diagnosis, through ...201727026974
[radiologic findings in gorham-stout syndrome].gorham-stout syndrome, also called "disappearing bone disease" or idiopathic massive osteolysis, is a rare disease of unknown etiology and pathogenesis. it is characterized by rapidly progressive localized massive osteolysis associated to a proliferation of vascular structures of benign origin in which the absence of new bone formation is representative. we present two cases (a six-year-old boy with affected right ulna, and a 15-year-old girl with right rib affection associated to chylothorax) o ...201717059207
gorham-stout disease of the humerus.gorham-stout disease is characterized by local proliferation of small vascular or lymphatic channels resulting in progressive destruction and resorption of bone. the etiology and pathogenesis of the disease remains mostly unknown, despite some 175 reported cases. a case of gorham-stout disease of the humerus in a 14-year-old boy is described. the patient presented with progressive pain and deformity of the right arm. although the disease was described in different bones of the body its location ...201618447124
successful conservative management of gorham disease of the skull base and cervical spine.gorham's disease, also called massive osteolysis or vanishing bone disease, is an enigmatic condition caused by endothelial proliferation occurring in bone and soft tissue. death is frequent when there is spinal or visceral involvement. we present a case of spinal and skull base gorham's disease that was reversed by radiation therapy administered while the spine was supported by a halo vest. the literature is reviewed.20169454981
massive osteolysis of the shoulder (gorham-stout syndrome). 201610389088
[gorham disease disclosed by pathological fracture]. 20161410904
ct and mri of gorham syndrome.gorham syndrome, also known as massive osteolysis or vanishing bone, is a rare disorder (135 cases reported) leading to extensive loss of bony matrix, replaced by proliferating thin-walled vascular channels. three histologically proven cases of the disease are reported, including the clinical presentation and modern imaging features with ct (with 3d reconstruction) as well as t1- and t2-weighted mri. two cases in young women were located in the pelvis with extensive osteolysis reaching to the ac ...20167962815
ct and mri of massive osteolysis of gorham.massive osteolysis of gorham is a clinical, radiographic, and histologic entity characterized by histologically benign vascular proliferation involving bone associated with extensive osteolysis. we present ct and mri findings of the disease and serial radiography following the progressing bone destruction.20167962814
carboxymethyl cellulose coating and low-dose gamma irradiation improves storage quality and shelf life of pear (pyrus communis l., cv. bartlett/william).carboxymethyl cellulose (cmc) coatings alone and in combination with gamma irradiation were tested for maintaining the storage quality and extending shelf life of pear. matured green pears were cmc coated at levels 0.25% to 1.0% w/v and gamma irradiated at 1.5 kgy. the treated fruit including control was stored under ambient (temperature 25 ± 2 °c, rh 70%) and refrigerated (temperature 3 ± 1 °c, rh 80%) conditions. irradiation alone at 1.5 kgy gave 8 and 4 d extension in shelf life of pear follo ...201621535615
symmetric metastatic melanoma of unknown primary, presenting as gorham-stout syndrome. 201621512676
a case of an idiopathic massive osteolysis with skip lesions.a patient with a 2-year history of pain in the left arm, and decreased strengths unrelieved by non-steroidal anti-inflammatory therapy, was being referred for repeating radiography. the radiologic examinations have demonstrated a unique pattern of non-contiguous osteolysis in the left elbow, proximal and distal radius, ulna, wrist, carpal bones, proximal and distal metacarpals and phalanges. multi-site biopsies were being performed and confirmed the diagnosis of massive osteolysis. to our knowle ...201624265571
invasive lymphatic malformation (gorham-stout) of the pelvis with prominent skin involvement.gorham-stout syndrome is a rare disease characterized by progressive osteolysis leading to disappearance of the bone. vascular proliferations have been implicated in the pathogenesis of this syndrome. the case of a 7-year-old girl with a prominent invasive lymphatic malformation on the lumbosacral area and massive osteolysis of the pelvic girdle is reported.201622823281
treatment of early-onset gorham syndrome with 8-year follow-up.a case of gorham disease with several years of follow-up is reported. at birth he had a mass in the thigh which was had pathology demonstrating a lymphangioma. by age 3 years, he had lymphedema of the ipsilateral foot and discrepant leg lengths. radiography revealed heterogenous dystrophy of the bones and osteolysis of the hallux. at age 6, a spontaneous fracture of the right tibia was treated with surgery. histopathology of a bone sample demonstrated bone remodelling, fibrous tissue, and large ...201622380698
efficacy of 1-methylcyclopropene on the mitigation of storage disorders of "rocha" pear under normal refrigerated and controlled atmospheres.alternatives are needed for long-term preservation of european pears (pyrus communis l.) after the ban on diphenylamine. "rocha" pear fruit harvested at commercial maturity were treated with 1-methylcyclopropene (1-methylcyclopropene, smartfresh™) and diphenylamine and stored at 0 ℃, 90-95% relative humidity, under normal atmosphere for up to six months or under controlled atmosphere (controlled atmosphere, 3 kpa o2 + 0.7 kpa co2) for up to 9.4 months. at 312 nl l(-1), 1-methylcyclopropene reduc ...201626437671
disappearing bone disease of the humerus and the cervico-thoracic spine: a case report with 42-year follow-up.disappearing bone disease (dbd) is a rare idiopathic musculoskeletal disorder that is distinguished by bone resorption without bone formation, vascular or lymphatic vessel proliferation, and soft-tissue swelling. long-term follow-up of a patient with dbd has rarely been reported in the literature.201626436955
pulmonary and pleural lymphatic endothelial cells from pediatric, but not adult, patients with gorham-stout disease and generalized lymphatic anomaly, show a high proliferation rate.gorham-stout disease (omim 123880) and generalized lymphatic anomaly are two rare disorders of lymphendothelial growth in which thoracic involvement with chylothorax is a feared complication. currently it is believed that both disorders are prenatal malformations that progress slowly after birth. several pharmaceuticals with antiproliferative properties, including interferon-α-2b, rapamycin and propranolol, have however been shown to affect the disease course in some patients. deeper knowledge o ...201627194137
gorham-stout syndrome of the shoulder.gorham-stout syndrome (gss) is a rare but severe subtype of idiopathic osteolysis. there are no guidelines for the treatment of gss. we analysed different diagnostic and therapeutic regimes and we describe the sucessful treatment of gss considering individual patient factors.201627194110
craniofacial ct findings of gorham-stout disease and generalized lymphatic anomaly.the present study aimed to assess the craniofacial ct imaging features for differentiating between gorham-stout disease (gsd) and generalized lymphatic anomaly (gla).201627126342
biochemical basis of co2-related internal browning disorders in pears (pyrus communis l. cv. rocha) during long-term storage.this study aimed at understanding the biochemical basis of internal browning disorders (ibds) in 'rocha' pear. for this purpose, the effects of storage under normal controlled atmosphere (ca) (3 kpa of o2 + 0.5 kpa of co2) and ibd-inducing ca (1 kpa of o2 + 10 kpa of co2) on the antioxidant and fermentative metabolisms and polyphenol oxidase (ppo) activity and phenolics concentration were studied. the higher ibd incidence in high co2-stored fruits was positively correlated with fermentative meta ...201627118401
massive craniofacial gorham disease treated successfully by cisplatin and 5-fluorouracil with ten years of follow-up: a case report and literature review.gorham disease (gd) is a rare osteolytic condition of unknown etiology that causes spontaneous, progressive bone resorption. the maxillofacial area is one of the regions most frequently involved in this disease. gd is characterized by its aggressiveness and rarity; therefore, the treatment modalities remain controversial, and no specific treatment method has been proved effective. the present report describes a case of gd with massive craniofacial bone involvement that was treated effectively us ...201627102925
anatomic and functional evaluation of central lymphatics with noninvasive magnetic resonance lymphangiography.accurate assessment of the lymphatic system has been limited due to the lack of optimal diagnostic methods. recently, we adopted noncontrast magnetic resonance (mr) lymphangiography to evaluate the central lymphatic channel. we aimed to investigate the feasibility and the clinical usefulness of noninvasive mr lymphangiography for determining lymphatic disease.ten patients (age range 42-72 years) with suspected chylothorax (n = 7) or lymphangioma (n = 3) who underwent mr lymphangiography were inc ...201627015184
more for less: improving the biomass yield of a pear cell suspension culture by design of experiments.plant cell suspension cultures are widely used for the production of recombinant proteins and secondary metabolites. one of the most important steps during process development is the optimization of yields by testing different cultivation parameters, including the components of the growth medium. however, we have shown that the biomass yield of a cell suspension culture derived from the pear cultivar pyrus communis cv. champagner bratbirne can be significantly improved solely by varying the temp ...201626988402
surgical management of gorham disease involving the upper cervical spine with occipito-cervical-thoracic fusion: a case report.gorham disease is a rare osteolytic condition, with only 17 reported cases primarily affecting the cervical spine.201626975457
chemical composition and antioxidant capacity of different anatomical parts of pear (pyrus communis l.).sugar, organic acid, triterpenoid and phenolic composition as well as antioxidant capacity of different anatomical parts of pear were studied. fruits and leaves of 'radana' pear (pyrus communis l.) were used. the results showed great quantitative differences in the composition of the pear pulp, peel, leaves and seeds. fructose was the major sugar in pulp, seeds and peel (227.46, 45.36 and 67.49 g/kg dry mass [dm], respectively), while sorbitol was predominant in leaves (40.66 g/kg dm). malic aci ...201626948642
gorham-stout disease of the pelvis: seven years follow up with complete radiological evaluation. 201626944827
novel approach of treating gorham-stout disease in the humerus--case report and review of literature.gorham-stout disease or the so-called vanishing bone syndrome is a rare disorder characterized by intra-osseous proliferation of vascular channels resulting in destruction and resorption of the osseous matrix. the exact pathology of this disease showed no evidence of malignant, neuropathic, or infectious components involved in the causation of this disorder except for the culprit of lympho-vascular malformations in the bone. the mechanism of bone resorption is yet to be clarified. the clinical p ...201626914115
gorham-stout disease successfully treated with sirolimus and zoledronic acid therapy.gorham-stout disease is a life-threatening disorder often manifested by lymphatic malformation and osteolysis. unfortunately, available therapies are not uniformly effective and often carry substantial morbidity. we report an 18-year-old male with gorham-stout disease manifested by lytic rib lesions and an intractable pleural effusion that responded dramatically to the combination of the mammalian target of rapamycin (mtor) inhibitor sirolimus and the aminobisphosphonate zoledronic acid after fa ...201626886375
rare incidence of gorham disease with limited involvement of the maxilla: case report. 201626818112
clinical features and prognosis of generalized lymphatic anomaly, kaposiform lymphangiomatosis, and gorham-stout disease.complex lymphatic anomalies are intractable lymphatic disorders, including generalized lymphatic anomaly (gla), gorham-stout disease (gsd), and kaposiform lymphangiomatosis (kla). the etiology of these diseases remains unknown and diagnosis is confused by their similar clinical findings. this study aimed to clarify the differences in clinical features and prognosis among gla, kla, and gsd, in japanese patients.201626806875
fast detection of phenolic compounds in extracts of easter pears (pyrus communis) from the atacama desert by ultrahigh-performance liquid chromatography and mass spectrometry (uhplc-q/orbitrap/ms/ms).a small chilean variety of pears growing in the town of toconao, an oasis located at the northeastern edge of the salar de atacama, northern chile, was studied by means of modern pda and high resolution mass spectral data (uhplc-pda-hesi-orbitrap-ms/ms). in addition, the antioxidant features of the fruits were compared with the varieties packhman's triumph and abate fetel and correlated with the presence of phenolic compounds. the non-pigmented phenolics were fingerprinted and related to the ant ...201626784158
quantitative proteomics-based reconstruction and identification of metabolic pathways and membrane transport proteins related to sugar accumulation in developing fruits of pear (pyrus communis).during their 6 month development, pear (pyrus communis) fruits undergo drastic changes in their morphology and their chemical composition. to gain a better understanding of the metabolic pathways and transport processes active during fruit development, we performed a time-course analysis using mass spectrometry (ms)-based protein identification and quantification of fruit flesh tissues. after pre-fractionation of the samples, 2,841 proteins were identified. a principal component analysis (pca) s ...201626755692
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