Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| pathogenicity and transmissibility assessment of two strains of human influenza virus isolated in china in 2018. | influenza season occurs every year in china, but its presentation was unusual in the period from december 2017 to early 2018. during this period, influenza activity was increasing across the country and was much greater than during the same period in previous years, with great harm to people's health. | 2021 | 33472481 |
| safety and immunogenicity of a novel quadrivalent subunit influenza vaccine in animal models. | background: compared with trivalent influenza vaccines, quadrivalent influenza vaccines are expected to provide wider protection against influenza b virus infections. we developed a novel quadrivalent subunit influenza vaccine which was distinct from the influenza vaccines available on the market in production process. in this research, we evaluated the safety and immunogenicity of the quadrivalent subunit influenza vaccine in animal models.methods: in toxicity assessment, 40 sd rats were random ... | 2020 | 32186950 |
| selective usage of anp32 proteins by influenza b virus polymerase: implications in determination of host range. | the influenza b virus (ibv) causes seasonal influenza and has accounted for an increasing proportion of influenza outbreaks. ibv mainly causes human infections and has not been found to spread in poultry. the replication mechanism and the determinants of interspecies transmission of ibv are largely unknown. in this study, we found that the host anp32 proteins are required for the function of the ibv polymerase. human anp32a/b strongly supports ibv replication, while anp32e has a limited role. un ... | 2020 | 33045004 |
| quadrivalent cell culture influenza virus vaccine. comparison to egg-derived vaccine. | influenza virus infections pose a serious public health problem and vaccination is the most effective public health intervention against them. the current manufacture of influenza vaccines in embryonated chicken eggs entails significant limitations. these limitations have been overcome by producing vaccines in cell culture, which allow a faster and more flexible response to potential pandemic threats. given the impact of influenza b virus on disease burden, the availability of quadrivalent vacci ... | 2020 | 32255723 |
| divergent influenza-like viruses of amphibians and fish support an ancient evolutionary association. | influenza viruses (family orthomyxoviridae) infect a variety of vertebrates, including birds, humans, and other mammals. recent metatranscriptomic studies have uncovered divergent influenza viruses in amphibians, fish and jawless vertebrates, suggesting that these viruses may be widely distributed. we sought to identify additional vertebrate influenza-like viruses through the analysis of publicly available rna sequencing data. accordingly, by data mining, we identified the complete coding segmen ... | 2020 | 32962015 |
| antiviral properties of extracts of streptomyces sp. smu 03 isolated from the feces of elephas maximus. | actinobacteria are historically and continued to be an important source for drug discovery. the annual epidemics and periodic pandemics of humans induced by influenza a virus (iav) prompted us to develop new effective antiviral drugs with different modes of action. an actinobacterium of streptomyces sp. smu 03 was identified from the feces of elephas maximus in yunnan province, china. by employing an h5n1 pseudo-typed virus drug screening system, the anti-iav effect of the dichloromethane extrac ... | 2020 | 32330578 |
| mucosal immunity against neuraminidase prevents influenza b virus transmission in guinea pigs. | despite efforts to control influenza virus infection and transmission, influenza viruses still cause significant morbidity and mortality in the global human population each year. most of the current vaccines target the immunodominant hemagglutinin surface glycoprotein of the virus. however, reduced severity of disease and viral shedding have also been linked to antibodies targeting the second viral surface glycoprotein, the neuraminidase. importantly, antineuraminidase immunity was shown to be r ... | 2019 | 31113896 |
| the tree shrew is a promising model for the study of influenza b virus infection. | influenza b virus is a main causative pathogen of annual influenza epidemics, however, research on influenza b virus in general lags behind that on influenza a viruses, one of the important reasons is studies on influenza b viruses in animal models are limited. here we investigated the tree shrew as a potential model for influenza b virus studies. | 2019 | 31174549 |
| passaging of an influenza a(h1n1)pdm09 virus in a difluoro sialic acid inhibitor selects for a novel, but unfit i106m neuraminidase mutant. | an influenza a(h1n1)pdm09 and an influenza b virus were passaged in 3-fluoro(eq)-4-guanidino difluoro sialic acid (3feq4gu dfsa), an inhibitor of the influenza neuraminidase (na) to determine whether resistant variants could be selected. 3feq4gu dfsa is a mechanism-based inhibitor, forming a covalent link to y406 in the na active site. given its similarity to the natural substrate, sialic acid, we predicted resistant variants would be difficult to select. yields of both viruses decreased with pa ... | 2019 | 31233807 |
| cross-reactive and lineage-specific single domain antibodies against influenza b hemagglutinin. | influenza b virus (ibv) circulates in the human population and causes considerable disease burden worldwide, each year. current ibv vaccines can struggle to mount an effective cross-reactive immune response, as strains become mismatched, due to constant antigenic changes. additional strategies which use monoclonal antibodies, with broad reactivity, are of considerable interest, both, as diagnostics and as immunotherapeutics. alternatives to conventional monoclonal antibodies, such as single doma ... | 2019 | 31544820 |
| [swine-spread severe influenza-associated pneumonia: a case report and literature review]. | we report and analyze the clinical data of the first case of severe pneumonia caused by influenza b virus from swine. the patient, a 62 year-old male domestic pig breeder, was admitted to hospital because of fever and muscle pain for 5 days, and anhelation for 3 days. one week before the onset of disease, the patient kept close contact with pigs. ct scan of the chest showed diffuse infiltration in both lungs. influenza b virus antigen detection (colloidal gold method) was repeatedly positive. th ... | 2018 | 30643075 |
| cross-protective efficacy of monovalent live influenza b vaccines against genetically different lineages of b/victoria and b/yamagata in ferrets. | currently, two genetic lineages of influenza b virus, b/victoria and b/yamagata, are cocirculating in humans in various countries. this situation has raised a question regarding the possibility of cross-protection between b components of live attenuated influenza vaccine (laiv) belonging to different lineages. this study aimed to assess in naïve ferrets the potential protective activity of monovalent b-laivs against challenge with homologous and heterologous wild-type (wt) influenza b viruses. | 2018 | 30246028 |
| anti-influenza a viral butenolide from streptomyces sp. smu03 inhabiting the intestine of elephas maximus. | actinobacteria are a phylum of bacteria known for their potential in producing structurally diversified natural products that are always associated with a broad range of biological activities. in this paper, using an h5n1 pseudo-typed virus drug screening system combined with a bioassay guided purification approach, an antiviral butanolide (1) was identified from the culture broth of streptomyces sp. smu03, a bacterium isolated from the feces of elephas maximus in yunnan province, china. this co ... | 2018 | 29976861 |
| circulation of influenza b lineages in northern viet nam, 2007-2014. | influenza b viruses circulate throughout viet nam, and their activities vary by region. there have been two antigenically distinct lineages of influenza b viruses co-circulating in the past 20 years; however, only one lineage is selected as a component of contemporary trivalent seasonal influenza vaccines. to improve the understanding of circulating influenza b lineages and influenza vaccine mismatches, we report the virus lineages circulating in northern viet nam over an eight-year period (2007 ... | 2017 | 26798557 |
| a case of cardiogenic shock secondary to complement-mediated myopericarditis from influenza b infection. | influenza b is a rare cause of myocarditis that is usually caused by histiocytic and mononuclear cellular infiltrates. we describe a 22-year-old female patient presenting with fulminant myopericarditis secondary to influenza b infection that deteriorated to cardiogenic shock. endomyocardial biopsy results yielded myocardial necrosis through complement-mediated cellular injury without evidence of interstitial infiltrates. the rare cause of this patient's disease, along with the unique pathologic ... | 2017 | 28844428 |
| outbreaks of influenza b infection and pneumococcal pneumonia at a mental health facility in japan. | japan has an aging population and an increasing number of patients who reside in long-term care and mental health facilities. both pneumococcal pneumonia and influenza b infection outbreaks have been observed in these populations, although no reports have described concurrent outbreaks of pneumococcal pneumonia and influenza b infection in these facilities. | 2017 | 28838778 |
| broadly protective murine monoclonal antibodies against influenza b virus target highly conserved neuraminidase epitopes. | a substantial proportion of influenza-related childhood deaths are due to infection with influenza b viruses, which co-circulate in the human population as two antigenically distinct lineages defined by the immunodominant receptor binding protein, haemagglutinin. while broadly cross-reactive, protective monoclonal antibodies against the haemagglutinin of influenza b viruses have been described, none targeting the neuraminidase, the second most abundant viral glycoprotein, have been reported. her ... | 2017 | 28827718 |
| benign acute childhood myositis during influenza b outbreak. | benign acute childhood myositis (bacm) is a syndrome classically occurring in children during the convalescent phase from a febrile upper respiratory tract infection, most commonly after influenza b. bacm can cause difficulty walking due to severe calf pain. laboratory results show increased serum creatinine kinase and ast. although alarming, bacm is self-limiting with symptoms disappearing within a week. herein, we described a case series of bcam in children in two cities in poland during the i ... | 2017 | 28795360 |
| pathogenicity and peramivir efficacy in immunocompromised murine models of influenza b virus infection. | influenza b viruses are important human pathogens that remain inadequately studied, largely because available animal models are poorly defined. here, we developed an immunocompromised murine models for influenza b virus infection, which we subsequently used to study pathogenicity and to examine antiviral efficacy of the neuraminidase inhibitor peramivir. we studied three influenza b viruses that represent both the yamagata (b/massachusetts/2/2012 and b/phuket/3073/2013) and victoria (b/brisbane/ ... | 2017 | 28779075 |
| encephalopathy associated with influenza b in a healthy young man. | a 19-year-old man presented with a fever, convulsions, and loss of consciousness at our hospital. the patient had a glasgow coma scale score of 12. influenza b virus infection was diagnosed using the rapid test kit, and an eight-fold increase in the serum levels of anti-influenza b virus antibody was confirmed using the complement fixation test. brain magnetic resonance imaging showed multifocal high-signal lesions, and an electroencephalogram showed diffuse slowing of the background activity, i ... | 2017 | 28717095 |
| safety and immunogenicity of a quadrivalent influenza vaccine in adults 65 years of age and older. | frequent mismatches between the predominant circulating b strain lineage and the b strain lineage in trivalent influenza vaccines have resulted in missed opportunities to prevent influenza illness. quadrivalent influenza vaccines containing b strains from each of the two lineages have been developed for improved prevention of influenza b infections. here, we describe the results of a phase iii, randomized, double-blind, active-controlled, multicenter trial examining the safety and immunogenicity ... | 2017 | 28700265 |
| influenza b meningoencephalitis. | 2017 | 28690035 | |
| rationale for two influenza b lineages in seasonal vaccines: a meta-regression study on immunogenicity and controlled field trials. | b lineage mismatch prompted introduction of quadri-valent influenza vaccines (qiv) with two influenza b viruses representing distinct antigenic lineages. to explore the impact on antibody induction and vaccine effectiveness predicted from antibody (veab), we performed a systematic literature search on immunogenicity studies conducted to assess antibody superiority of qiv over trivalent influenza vaccine (tiv). thirteen relevant articles described 31 trials from 2007 and 2013. log-transformed gmt ... | 2017 | 28655451 |
| a systematic review of the health economic consequences of quadrivalent influenza vaccination. | quadrivalent influenza vaccines (qivs) contain antigens derived from an additional influenza type b virus as compared with currently used trivalent influenza vaccines (tivs). this should overcome a potential reduced vaccine protection due to mismatches between tiv and circulating b viruses. in this study, we systematically reviewed the available literature on health economic evaluations of switching from tiv to qiv. areas covered: the databases of medline and embase were searched systematically ... | 2017 | 28613092 |
| first report of immunogenic vasculitis with wunderlich's syndrome following influenza b infection in a previously immunocompetent woman. | 2017 | 28595807 | |
| development and identification of a new vero cell-based live attenuated influenza b vaccine by a modified classical reassortment method. | it was to generate a new vero and cold-adapted live attenuated influenza b vaccine with enough safety and immunogenicity. | 2017 | 28581345 |
| a phase 1, randomized, double-blind, placebo-controlled, single-ascending-dose study to investigate the safety, tolerability, and pharmacokinetics of an anti-influenza b virus monoclonal antibody, mhab5553a, in healthy volunteers. | influenza b can cause significant morbidity and mortality. mhab5553a, a human monoclonal immunoglobulin g1 (igg1) antibody that binds to a highly conserved region of the hemagglutinin protein of influenza b virus, is being examined as a novel therapeutic for the treatment of influenza b patients with severe disease. this phase 1, randomized, double-blind, placebo-controlled, single-ascending-dose study was conducted to assess the safety, tolerability, and pharmacokinetics (pk) of mhab5553a. twen ... | 2017 | 28559255 |
| [benign acute childhood myositis: clinical series and literature review]. | benign acute childhood myositis (bacm) is a rare clinical condition that mainly affects pre-school and school age-children. it is usually preceded by a viral illness, particularly influenza virus infection. | 2017 | 28542661 |
| epidemiology of influenza b/yamagata and b/victoria lineages in south africa, 2005-2014. | studies describing the epidemiology of influenza b lineages in south africa are lacking. | 2017 | 28542324 |
| corrigendum: a broadly protective therapeutic antibody against influenza b virus with two mechanisms of action. | this corrects the article doi: 10.1038/ncomms14234. | 2017 | 28541305 |
| a review of the value of quadrivalent influenza vaccines and their potential contribution to influenza control. | the contribution of influenza b to the seasonal influenza burden varies from year-to-year. although 2 antigenically distinct influenza b virus lineages have co-circulated since 2001, trivalent influenza vaccines (tivs) contain antigens from only one influenza b virus. b-mismatch or co-circulation of both b lineages results in increased morbidity and mortality attributable to the b lineage absent from the vaccine. quadrivalent vaccines (qivs) contain both influenza b lineages. we reviewed current ... | 2017 | 28532276 |
| a trivalent, inactivated influenza vaccine (vaxigrip®): summary of almost 50 years of experience and more than 1.8 billion doses distributed in over 120 countries. | vaxigrip, a trivalent split-virion, inactivated vaccine available since 1968 has been in use longer than any other influenza vaccine. it is the most widely-used influenza vaccine, with more than 1.8 billion doses distributed in more than 120 countries. areas covered: the significant body of evidence that confirms the efficacy, effectiveness, immunogenicity, and safety of vaxigrip in healthy individuals of all ages and at-risk populations is summarized. the results from at least 15 randomized eff ... | 2017 | 28460594 |
| determination of influenza b identity and potency in quadrivalent inactivated influenza vaccines using lineage-specific monoclonal antibodies. | co-circulation of two antigenically and genetically distinct lineages of influenza b virus, represented by prototype viruses b/victoria/2/1987 and b/yamagata/16/1988, has led to the development of quadrivalent influenza vaccines that contain two influenza b antigens. the inclusion of two influenza b antigens presents challenges for the production and regulation of inactivated quadrivalent vaccines, including the potential for cross-reactivity of the reagents used in identity and potency assays b ... | 2017 | 28423025 |
| [prevalence and risk factors of respiratory viral infection in acute exacerbation of chronic obstructive pulmonary disease]. | objective: to study the prevalence of respiratory viral infection in chronic obstructive pulmonary disease(copd) exacerbations and to find the factors associated with susceptibility to viral infections. methods: eighty patients with exacerbations of copd and 50 stable copd patients were recruited. nasopharyngeal swabs were tested for a range of 18 different respiratory viruses using pcr. results: among the copd exacerbations, viral infection was detected in 18 episodes (22.5%) . the most common ... | 2017 | 28395404 |
| [kleine-levin syndrome: differential diagnosis in recurrent encephalitic syndromes in adolescence]. | the kleine-levin syndrome is a rare disease of unknown origin characterized by recurrent and self-limited episodes of hypersomnia that are also accompanied by a cognitive and behavioral dysfunction. patients present normal sleeping and behavior patterns between episodes. | 2017 | 28345736 |
| antiviral drug-resistant influenza b viruses carrying h134n substitution in neuraminidase, laos, february 2016. | in february 2016, three influenza b/victoria/2/87 lineage viruses exhibiting 4- to 158-fold reduced inhibition by neuraminidase inhibitors were detected in laos. these viruses had an h134n substitution in the neuraminidase and replicated efficiently in vitro and in ferrets. current antiviral drugs may be ineffective in controlling infections caused by viruses harboring this mutation. | 2017 | 28322707 |
| does seasonal vaccination affect the clinical presentation of influenza among the elderly? a cross-sectional analysis in the outpatient setting in france, 2003-2014. | vaccine-induced protection against influenza is not optimal, however it has been suggested that the vaccine may reduce the severity of symptoms among those who develop illness despite being vaccinated. we tested this hypothesis within a countrywide, sentinel general practitioners-based surveillance system in france. we included 2277 individuals aged 65years or older (of whom 1293 had been vaccinated against influenza, 56.8%) who consulted a general practitioner because of an acute respiratory in ... | 2017 | 28291646 |
| electronic alerts improve immunization rates in two-month-old premature infants hospitalized in the neonatal intensive care unit. | to determine if an electronic alert improves 2 month immunization rates in infants remaining hospitalized in the neonatal intensive care unit. | 2017 | 28246672 |
| whole-genome phylogenetic analysis of influenza b/phuket/3073/2013-like viruses and unique reassortants detected in malaysia between 2012 and 2014. | reassortment of genetic segments between and within influenza b lineages (victoria and yamagata) has been shown to generate novel reassortants with unique genetic characteristics. based on hemagglutinin (ha) and neuraminidase (na) genes, recent surveillance study has identified reassortment properties in b/phuket/3073/2013-like virus, which is currently used in the who-recommended influenza vaccine. to understand the potential reassortment patterns for all gene segments, four b/phuket/3073/2013- ... | 2017 | 28129386 |
| an in vitro fluorescence based study of initiation of rna synthesis by influenza b polymerase. | influenza polymerase replicates, via a complementary rna intermediate (crna), and transcribes the eight viral rna (vrna) genome segments. to initiate rna synthesis it is bound to the conserved 5΄ and 3΄ extremities of the vrna or crna (the 'promoter'). 5΄-3΄ base-pairing in the distal promoter region is essential to position the template rna at the polymerase active site, as shown by a new crystal structure with the 3΄ end threading through the template entry tunnel. we develop fluorescence pola ... | 2017 | 28126917 |
| spatio-temporal patterns of proportions of influenza b cases. | we studied the spatio-temporal patterns of the proportions of influenza b cases out of all typed cases, with data from 139 countries and regions downloaded from the flunet compiled by the world health organization, from january 2006 to october 2015. we restricted our analysis to 34 countries that reported more than 2,000 confirmations for each of types a and b over the study period. globally, we found that pearson's correlation is greater than 0.6 between effective distance from mexico and the p ... | 2017 | 28067277 |
| antisynthetase syndrome and influenza b, characteristic pulmonary involvement. | 2017 | 28063779 | |
| time to change dosing of inactivated quadrivalent influenza vaccine in young children: evidence from a phase iii, randomized, controlled trial. | children under 3 years of age may benefit from a double-dose of inactivated quadrivalent influenza vaccine (iiv4) instead of the standard-dose. | 2017 | 28062552 |
| effects of prebiotics on the immune response to vaccination in the elderly. | prebiotics stimulate the growth of bifidogenic bacteria in the gut. the aim of this work was to assess the effects of a prebiotic mixture on the immune response in healthy elderly people. | 2017 | 12405649 |
| evolutionary dynamic of antigenic residues on influenza b hemagglutinin. | hemagglutinin (ha) of seasonal influenza virus evolves under positive selection pressure exerted by host immunity. it was previously shown that antigenic drift in different influenza b sublineages during different time periods distributed unevenly among different epitopes, and that more recent viruses up to 2007 might have their antigenic drift more focused on certain epitope. we further analyzed whether more recent influenza b viruses up to 2016 followed that same pattern of antigenic evolution ... | 2017 | 28024225 |
| extensive swelling of the limb and systemic symptoms after a fourth dose of acellular pertussis containing vaccines in england in children aged 3-6years. | extensive limb swelling (esl) after a booster dose of acellular pertussis (ap) containing vaccine can cause concern and has the potential to be confused with cellulitis. in the united kingdom ap-containing vaccine was introduced for primary immunisation at 2, 3 and 4months of age in 2004, with the first cohorts eligible to receive a fourth dose in 2007 at school entry. we assessed the frequency of esl (here defined as swelling >100mms diameter) in 973 children receiving a fourth dose of one of f ... | 2017 | 28017441 |
| estimation of influenza-attributable medically attended acute respiratory illness by influenza type/subtype and age, germany, 2001/02-2014/15. | the total burden of influenza in primary care is difficult to assess. the case definition of medically attended "acute respiratory infection" (maari) in the german physician sentinel is sensitive; however, it requires modelling techniques to derive estimates of disease attributable to influenza. we aimed to examine the impact of type/subtype and age. | 2017 | 27754611 |
| economic outcomes of influenza in hospitalized elderly with and without icu admission. | to describe direct medical costs of influenza in hospitalized elderly, with and without intensive care unit (icu) admission, during the 2014-2015 season in hong kong. | 2017 | 27740538 |
| fifteen years of epidemiologic, virologic and syndromic influenza surveillance: a focus on type b virus and the effects of vaccine mismatch in liguria region, italy. | in order to estimate the burden of influenza and to describe the genetic evolutionary pattern and antigenic variability of type b viral strains, data deriving from 3 surveillance systems active in liguria region, northern italy, were described. since the re-emergence of the victoria lineage in 2001, the clinical-epidemiological and syndromic surveillances demonstrated the heavy burden of influenza like illness (ili) syndrome. focusing on type b influenza virus, it predominated or played a releva ... | 2017 | 27924684 |
| review of seasonal influenza in canada: burden of disease and the cost-effectiveness of quadrivalent inactivated influenza vaccines. | in the 2015/16 influenza season, the canadian national advisory committee on immunization (naci) recommended vaccination with quadrivalent inactivated influenza vaccine (qiv) for infants aged 6-23 months and trivalent inactivated influenza vaccines (tivs) or qivs in adults. the objective of this review (gsk study identifier: ho-13-14054) is to examine the epidemiology and disease burden of influenza in canada and the economic benefits of vaccination. to inform this review, we performed a systema ... | 2017 | 27858509 |
| influenza surveillance in russia based on epidemiological and laboratory data for the period from 2005 to 2012. | exchange of information on and sharing of influenza viruses through the gisrs network has great significance for understanding influenza virus evolution, recognition of a new pandemic virus emergence and for preparing annual who recommendations on influenza vaccine strain composition. influenza surveillance in russia is based on collaboration of two nics with 59 regional bases. most epidemiological and laboratory data are entered through the internet into the electronic database at the research ... | 2017 | 26561480 |
| influenza and rhinovirus viral load and disease severity in upper respiratory tract infections. | the role of viral load in respiratory viral infection is unclear. it is proposed that the viral load of some, but not all respiratory viruses correlate with disease severity. | 2017 | 27893998 |
| molecular characterization and phylogenetic analysis of human influenza a viruses isolated in iran during the 2014-2015 season. | influenza a viruses are an important cause of severe infectious diseases in humans and are characterized by their fast evolution rate. global monitoring of these viruses is critical to detect newly emerging variants during annual epidemics. here, we sought to genetically characterize influenza a/h1n1pdm09 and a/h3n2 viruses collected in iran during the 2014-2015 influenza season. a total of 200 nasopharyngeal swabs were collected from patients with influenza-like illnesses. swabs were screened f ... | 2017 | 28331993 |
| estimates of hospitalization attributable to influenza and rsv in the us during 1997-2009, by age and risk status. | estimates of influenza and respiratory syncytial virus (rsv) burden must be periodically updated to inform public health strategies. we estimated seasonal influenza- and rsv-attributable hospitalizations in the us from 1997 to 2009 according to age and risk status (nct01599390). | 2017 | 28320361 |
| viral co-infections among children with confirmed measles at hospitals in hanoi, vietnam, 2014. | to characterize viral co-infections among representative hospitalized measles cases during the 2014 hanoi outbreak. | 2017 | 28237484 |
| interim estimates of 2016-17 seasonal influenza vaccine effectiveness - united states, february 2017. | in the united states, annual vaccination against seasonal influenza is recommended for all persons aged ≥6 months (1). each influenza season since 2004-05, cdc has estimated the effectiveness of seasonal influenza vaccine to prevent influenza-associated, medically attended, acute respiratory illness (ari). this report uses data, as of february 4, 2017, from 3,144 children and adults enrolled in the u.s. influenza vaccine effectiveness network (u.s. flu ve network) during november 28, 2016-februa ... | 2017 | 28207689 |
| respiratory viruses in acute exacerbations of chronic obstructive pulmonary disease. | acute exacerbations of chronic obstructive pulmonary disease (aecopd) cause significant morbidity, mortality, and an inexorable decline of lung function. data from developed countries have shown viruses to be important causes of aecopd, but data from developing countries like india are scant. we set out to determine the contribution of viruses in the causation of hospitalized patients with aecopd. | 2017 | 28144057 |
| throat swabs in children with respiratory tract infection: associations with clinical presentation and potential targets for point-of-care testing. | diagnostic uncertainty over respiratory tract infections (rtis) in primary care contributes to over-prescribing of antibiotics and drives antibiotic resistance. if symptoms and signs predict respiratory tract microbiology, they could help clinicians target antibiotics to bacterial infection. this study aimed to determine relationships between symptoms and signs in children presenting to primary care and microbes from throat swabs. | 2017 | 28334924 |
| surveillance for respiratory infectious diseases caused by 6 common viruses in a recruit training site in the northern region of china. | recruit training sites are places with a high incidence of respiratory infectious diseases. effective surveillance for acute respiratory infectious diseases in a recruit training site is an important way to prevent disease outbreaks. | 2017 | 28373908 |
| development of an alternative modified live influenza b virus vaccine. | influenza b virus (ibv) is considered a major human pathogen, responsible for seasonal epidemics of acute respiratory illness. two antigenically distinct ibv ha lineages co-circulate worldwide with little cross-reactivity between each other. live attenuated influenza virus vaccines (laiv) have been shown to provide improved cross-protective immune responses compared to inactivated vaccines by eliciting local mucosal immunity and systemic b cell and t cell-mediated memory responses. we have previ ... | 2017 | 28381580 |
| a broadly protective therapeutic antibody against influenza b virus with two mechanisms of action. | influenza b virus (ibv) causes annual influenza epidemics around the world. here we use an in vivo plasmablast enrichment technique to isolate a human monoclonal antibody, 46b8 that neutralizes all ibvs tested in vitro and protects mice against lethal challenge of all ibvs tested when administered 72 h post infection. 46b8 demonstrates a superior therapeutic benefit over tamiflu and has an additive antiviral effect in combination with tamiflu. 46b8 binds to a conserved epitope in the vestigial e ... | 2017 | 28102191 |
| diagnostic performance and clinical feasibility of a point-of-care test for respiratory viral infections in primary health care. | inappropriately high levels of antibiotics are still prescribed in primary health care for respiratory tract infections (rtis). access to diagnostic point-of-care tests (pocts) for rtis might reduce this over-prescription. | 2017 | 28369370 |
| chimeric hemagglutinin constructs induce broad protection against influenza b virus challenge in the mouse model. | seasonal influenza virus epidemics represent a significant public health burden. approximately 25% of all influenza virus infections are caused by type b viruses and these infections can be severe, especially in children. current influenza virus vaccines are an effective prophylaxis against infection but are impacted by rapid antigenic drift which can lead to mismatches between vaccine strains and circulating strains. here, we describe a broadly protective vaccine candidate based on chimeric hem ... | 2017 | 28356526 |
| aurantiamide acetate from baphicacanthus cusia root exhibits anti-inflammatory and anti-viral effects via inhibition of the nf-κb signaling pathway in influenza a virus-infected cells. | baphicacanthus cusia root also names "nan ban lan gen" has been traditionally used to prevent and treat influenza a virus infections. here, we identified a peptide derivative, aurantiamide acetate (compound e17), as an active compound in extracts of b. cusia root. although studies have shown that aurantiamide acetate possesses antioxidant and anti-inflammatory properties, the effects and mechanism by which it functions as an anti-viral or as an anti-inflammatory during influenza virus infection ... | 2017 | 28119097 |
| evaluation of the point-of-care becton dickinson veritor™ rapid influenza diagnostic test in kenya, 2013-2014. | we evaluated the performance of the becton dickinson veritor™ system flu a + b rapid influenza diagnostic test (ridt) to detect influenza viruses in respiratory specimens from patients enrolled at five surveillance sites in kenya, a tropical country where influenza seasonality is variable. | 2017 | 28077093 |
| influenza b burden during seasonal influenza epidemics in france. | seasonal flu outbreaks are linked to the circulation of influenza virus type a or b. special attention has always been paid to influenza a epidemics; but recently, several studies have investigated the impact of influenza b virus epidemics, particularly as, since the 1980s, two antigenically different influenza b lineages co-circulate, raising the issue of vaccine matching. | 2017 | 28062245 |
| in vitro evaluation of the antiviral activity of methylglyoxal against influenza b virus infection. | influenza a and b virus infections are serious public health concerns globally. however, the concerns regarding influenza b infection have been underestimated. the currently used anti-influenza drugs have not provided equal efficacy for both influenza a and b viruses. susceptibility to neuraminidase (na) inhibitors has been observed to be lower for influenza b viruses than for influenza a viruses. moreover, the emergence of resistance to anti-influenza drugs underscores the need to develop new d ... | 2017 | 27558282 |
| neurologic complications of influenza b virus infection in adults, romania. | we characterized influenza b virus-related neurologic manifestations in an unusually high number of hospitalized adults at a tertiary care facility in romania during the 2014-15 influenza epidemic season. of 32 patients with a confirmed laboratory diagnosis of influenza b virus infection, neurologic complications developed in 7 adults (median age 31 years). these complications were clinically diagnosed as confirmed encephalitis (4 patients), possible encephalitis (2 patients), and cerebellar ata ... | 2017 | 28322689 |
| plasmonics-based detection of virus using sialic acid functionalized gold nanoparticles. | biosensor for the detection of virus was developed by utilizing plasmonic peak shift phenomenon of the gold nanoparticles and viral infection mechanism of hemagglutinin on virus and sialic acid on animal cells. the plasmonic peak of the colloidal gold nanoparticles changes with the aggregation of the particles due to the plasmonic interaction between nearby particles and the color of the colloidal nanoparticle solution changes from wine red to purple. sialic acid reduced and stabilized colloidal ... | 2017 | 28281252 |
| [evaluation of a new immunochromatographic kit for enhanced detection of influenza b virus]. | we have evaluated a new immunochromatographic kit, "kbm linecheck flu ab", which had been developed for enhanced detection of influenza b viruses. five strains of influenza a and b viruses were tested for reactivity and detection limits of the kit. compared with the detection limits of commercially available kit of quicknavi-flu, "kbm linecheck flu ab" showed a nearly equal reactivity to influenza a viruses, but quadruple reactivity to 2 influenza b viruses. also, "kbm linecheck flu ab" exhibite ... | 2017 | 28274128 |
| the use of saliva specimens for detection of influenza a and b viruses by rapid influenza diagnostic tests. | diagnostic tests for influenza infection commonly use nasopharyngeal swabs (nps) even though these are invasive to obtain. as an alternative specimen, we evaluated the diagnostic usefulness of saliva samples with rapid influenza diagnostic tests (ridts). | 2017 | 28111058 |
| occurrence of atypical hus associated with influenza b. | hemolytic uremic syndrome (hus) is a disease characterized by thrombotic microangiopathy with a triad of non-immune hemolytic anemia, thrombocytopenia, and renal impairment. approximately 10% of cases of hus are classified as atypical (ahus). while today many genetically forms of ahus pathology are known, only about 50% of carriers precipitate the disease. the reason remains unclear, and triggering events like intercurrent infections have been postulated. in rare cases, influenza a is the known ... | 2017 | 28110418 |
| regulation of kynurenine biosynthesis during influenza virus infection. | influenza a viruses (iavs) remain serious threats to public health because of the shortage of effective means of control. developing more effective virus control modalities requires better understanding of virus-host interactions. it has previously been shown that iav induces the production of kynurenine, which suppresses t-cell responses, enhances pain hypersensitivity and disturbs behaviour in infected animals. however, the regulation of kynurenine biosynthesis during iav infection remains elu ... | 2017 | 27860276 |
| evidence for influenza b virus lineage shifts and reassortants circulating in thailand in 2014-2016. | towards the surveillance of seasonal influenza viruses between august 2015 and june 2016, respiratory samples (n=3390) were collected from thai patients with influenza-like illness. one-hundred fifty-seven (4.6%) samples tested positive for influenza b virus by real-time reverse-transcription polymerase chain reaction (rt-pcr). while the influenza b virus yamagata lineage strains were more prevalent than the victoria lineage strains in 2015 (77.5% vs. 22.5%), the victoria lineage strains appeare ... | 2017 | 27845268 |
| influenza b virus outbreak at a religious residential school for boys in northern bangladesh, 2011. | national media reported a febrile illness among dormitory residents of a boys' religious school. we investigated the outbreak to identify cause. | 2017 | 27603154 |
| population-based hospitalization burden of lineage specific influenza b children in hong kong, 2004-2014. | influenza b virus has been perceived to cause less disease burden and milder disease when compared to influenza a, but recent studies suggest influenza b does have a significant impact. we aimed to estimate the burden of influenza b virus infections on hospitalizations in hong kong, in the context of virus lineage changes over time. | 2017 | 28387792 |
| pharmacokinetics of oral and intravenous oseltamivir treatment of severe influenza b virus infection requiring organ replacement therapy. | patients with severe influenza virus infection, multi-organ failure and organ replacement therapy may absorb and metabolize neuraminidase inhibitors differently. systematic pharmacokinetic/pharmacodynamic clinical trials are currently lacking in this high-risk group. inadequate dosing increases the risk of treatment failure and drug resistance, especially in severely ill patients with elevated virus loads. this study aims to explore the impact of organ replacement therapy on oseltamivir drug con ... | 2017 | 26994602 |
| bronchitis obliterans due to influenza b pneumonia complicated with staphylococcus aureus infection. | 2017 | 28238518 | |
| a clinical trial of intradermal and intramuscular seasonal influenza vaccination in patients with atopic dermatitis. | antibody responses to the inactivated seasonal influenza vaccine in patients with atopic dermatitis (ad) have not been carefully characterized. | 2017 | 28209343 |
| immunogenicity and safety of southern hemisphere inactivated quadrivalent influenza vaccine: a phase iii, open-label study of adults in brazil. | the world health organization influenza forecast now includes an influenza b strain from each of the influenza b lineages (b/yamagata and b/victoria) for inclusion in seasonal influenza vaccines. traditional trivalent influenza vaccines include an influenza b strain from one lineage, but because two influenza b lineages frequently co-circulate, the effectiveness of trivalent vaccines may be reduced in seasons of influenza b vaccine-mismatch. thus, quadrivalent vaccines may potentially reduce the ... | 2017 | 27912069 |
| molecular epidemiology and antigenic characterization of seasonal influenza viruses circulating in nepal. | influenza is one of the public health burdens in nepal and its epidemiology is not clearly understood. the objective of this study was to explore the molecular epidemiology and the antigenic characteristics of the circulating influenza viruses in nepal. | 2017 | 28714491 |
| us healthcare costs attributable to type a and type b influenza. | while the overall healthcare burden of seasonal influenza in the united states (us) has been well characterized, the proportion of influenza burden attributable to type a and type b illness warrants further elucidation. the aim of this study was to estimate numbers of healthcare encounters and healthcare costs attributable to influenza viral strains a and b in the us during the 2001/2002 - 2008/2009 seasons. healthcare encounters and costs in the us during the 2001/2002 - 2008/2009 seasons for i ... | 2017 | 28700268 |
| rationally designed influenza virus vaccines that are antigenically stable during growth in eggs. | influenza virus vaccine production is currently limited by the ability to grow circulating human strains in chicken eggs or in cell culture. to facilitate cost-effective growth, vaccine strains are serially passaged under production conditions, which frequently results in mutations of the major antigenic protein, the viral hemagglutinin (ha). human vaccination with an antigenically drifted strain is known to contribute to poor vaccine efficacy. to address this problem, we developed a replication ... | 2017 | 28588131 |
| multicenter clinical evaluation of the luminex aries flu a/b & rsv assay for pediatric and adult respiratory tract specimens. | influenza a and b viruses and respiratory syncytial virus (rsv) are three common viruses implicated in seasonal respiratory tract infections and are a major cause of morbidity and mortality in adults and children worldwide. in recent years, an increasing number of commercial molecular tests have become available to diagnose respiratory viral infections. the luminex aries flu a/b & rsv assay is a fully automated sample-to-answer molecular diagnostic assay for the detection of influenza a, influen ... | 2017 | 28539342 |
| prevention and control of emergent infectious disease with high specific antigen sensor. | this study aims to evaluate the application of a new type of high specificity antigen sensor in detecting the viruses in sudden infectious diseases. influenza a (h1n1) virus immunosensor was used for the respective determination of the six kinds of antigens of h1n1, h3n2 viral protein, ha protein of h7n9, influenza b virus, adenovirus, and ev71 virus of same dilution degree on the screen printed carbon electrode (spce), so as to test the specificity of the detection method. in addition, various ... | 2017 | 28521528 |
| bioaerosol sampling in clinical settings: a promising, noninvasive approach for detecting respiratory viruses. | seeking a noninvasive method to conduct surveillance for respiratory pathogens, we sought to examine the usefulness of 2 types of off-the-shelf aerosol samplers to detect respiratory viruses in singapore. | 2017 | 28480252 |
| usefulness of ct value in acute respiratory infections caused by respiratory syncytial virus a and b and influenza virus a (h1n1)pdm09, a (h3n2) and b. | acute respiratory infections of viral cause are very frequent entities. the difficulty in evaluating the detection of a virus in these entities could be solved by determining the viral load. | 2017 | 28601216 |
| frequency of respiratory viruses among patients admitted to 26 intensive care units in seven consecutive winter-spring seasons (2009-2016) in northern italy. | the role of respiratory viruses in the etiology of community-acquired pneumonia (cap) is still debated. the advent of molecular assays has improved the identification of viruses in patients with cap and according to published studies, viruses account for 11-55% of adult cap cases. | 2017 | 28527970 |
| host dihydrofolate reductase (dhfr)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus. | we have identified a series of 1-aryl-4,6-diamino-1,2-dihydrotriazines, structurally related to the antimalarial drug cycloguanil, as new inhibitors of influenza a and b virus and respiratory syncytial virus (rsv) via targeting of the host dihydrofolate reductase (dhfr) enzyme. most analogues proved active against influenza b virus in the low micromolar range, and the best compounds (11, 13, 14 and 16) even reached the sub-micromolar potency of zanamivir (ec50 = 0.060 μm), and markedly exceeded ... | 2017 | 28477572 |
| prevalence of co-infection between respiratory syncytial virus and influenza in children. | respiratory syncytial virus (rsv) and influenza have varying degree of seasonal overlap. | 2017 | 28012809 |
| respiratory syncytial virus and influenza are the key viral pathogens in children <2 years hospitalized with bronchiolitis and pneumonia in islamabad pakistan. | pneumonia remains a leading cause of morbidity and mortality in developing countries. comprehensive surveillance data are needed to review the prevention and control strategies. we conducted active surveillance of acute lower respiratory infections among children aged <2 years hospitalized at two hospitals of islamabad, pakistan. viral etiology was determined using real-time pcr on respiratory specimens collected during march 2011-april 2012. the overall mean age was 7.83 ± 5.25 months while no ... | 2017 | 27885562 |
| influenza vaccine effectiveness against influenza-associated hospitalization in 2015/16 season, beijing, china. | vaccination is recommended to prevent influenza virus infection and associated complications. this study aimed to estimate the influenza vaccine effectiveness (ve) against hospitalization in the 2015/16 season in beijing. | 2017 | 28456530 |
| clinical differences of influenza subspecies among hospitalized children. | clinical findings, mortality, and morbidity rates differ among influenza subspecies. awareness of these differences will lead physicians to choose the proper diagnostic and therapeutic strategies and to foresee possible complications. the aim of this study was to evaluate the clinical differences of influenza subspecies among hospitalized children. | 2017 | 28439196 |
| retrospective review of epidemic viral pneumonia cases in turkey: a multicenter study. | influenza a (h1n1) caused its first pandemic in 2009 in usa and mexico. since then, clinicians have exercised great care in order to make an early diagnosis of viral pneumonias. this is due in part to pandemic influenza a infection having greater impact on populations <65 years old than other viral strains, including seasonal influenza. chest radiographies of those affected displayed a rapid progression of patchy infiltrates, and a large proportion of individuals required admission to intensive ... | 2017 | 28413489 |
| evolution of the neuraminidase gene of seasonal influenza a and b viruses in thailand between 2010 and 2015. | the neuraminidase inhibitors (nais) oseltamivir and zanamivir are commonly used for the treatment and control of influenza a and b virus infection. however, the emergence of new influenza virus strains with reduced susceptibility to nais may appear with the use of these antivirals or even naturally. we therefore screened the neuraminidase (na) sequences of seasonal influenza virus a(h1n1), a(h1n1)pdm09, a(h3n2), and influenza b virus strains identified in thailand for the presence of substitutio ... | 2017 | 28410396 |
| comparison of three rapid influenza diagnostic tests with digital readout systems and one conventional rapid influenza diagnostic test. | rapid influenza diagnostic tests (ridts) show variable sensitivities in clinical settings. we aimed to compare three digital ridts and one conventional ridt. | 2017 | 28407318 |
| immunogenicity and safety of a cell culture-derived inactivated quadrivalent influenza vaccine (nbp607-qiv): a randomized, double-blind, multi-center, phase iii clinical trial in adults and elderly subjects. | the influenza b virus has two lineages; yamagata and victoria. the two lineages are antigenically distinct and it is difficult to expect cross-protection between the lineages. actually, the mismatch between circulating influenza b viruses and vaccine strains has been occurred frequently. the cell-culture system for the production of influenza vaccine can contribute to improve vaccine strain selection and expand vaccine supplies. we investigated the immunogenicity and safety of cell culture-deriv ... | 2017 | 28406746 |
| severe acute respiratory infection (sari) surveillance for hospitalized patients in northern vietnam, 2011-2014. | worldwide severe acute respiratory infections (sari) are leading causes of hospitalization, morbidity and mortality in children. the aim of this study was to identify viral pathogens responsible for sari in northern vietnam from 2011 to 2014. | 2017 | 28367882 |
| two doses of inactivated influenza vaccine improve immune response in solid organ transplant recipients: results of transgripe 1-2, a randomized controlled clinical trial. | influenza vaccine effectiveness is not optimal in solid organ transplant recipients (sotr). we hypothesized that a booster dose might increase it. | 2017 | 28362949 |
| repeated vaccination does not appear to impact upon influenza vaccine effectiveness against hospitalization with confirmed influenza. | annual influenza vaccine is recommended for those at greatest risk of severe influenza infection. recent reports of a negative impact of serial influenza vaccination on vaccine effectiveness (ve) raises concerns about the recommendation for annual influenza vaccines, particularly in persons at greatest risk. | 2017 | 28329167 |