Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| [pseudarthrosis and construct failure after lumbar pedicle subtraction osteotomy : influence of biomechanics, surgical technique, biology and avoidance strategies]. | there are numerous factors that can lead to construct failure and pseudarthrosis after corrective pedicle subtraction osteotomy (pso) in the lumbar spine. frequently, several factors are of relevance in these problematic cases. this article attempts to explain the surgical, biomechanical and biological aspects that should be understood in order to minimize the risk of pseudarthrosis and construct failure. it addresses technical varieties of the pso procedure as well as the surgical technique, th ... | 2018 | 29411050 |
| a rationally designed multi-functional antibiotic for the treatment of drug-resistant acne. | acne is a multifactorial skin disease, underpinned by colonization of propionibacterium acnes and inflammation. the emergence of resistant propionibacterium acnes strains has affected the current acne treatment algorithm. this setback served as an impetus for rationally designing a library of next-generation antibiotics that exhibit a bactericidal effect on resistant propionibacterium acnes as well as exert an immunomodulatory function to reduce inflammation. in silico screening revealed that on ... | 2018 | 29409921 |
| propionibacterium acnes-derived extracellular vesicles promote acne-like phenotypes in human epidermis. | acne vulgaris is an inflammatory disease occurring in the pilosebaceous unit and is the most common skin condition in young people. a gram-positive bacterium, propionibacterium acnes (p. acnes), has been suspected to contribute to the development of acne. here, we report that p. acnes constitutively releases extracellular vesicles (evs) exhibiting typical ev morphology and size. moreover, the p. acnes-derived evs (pevs) can induce acne-like phenotypes in human epidermal keratinocytes and a recon ... | 2018 | 29409885 |
| propionibacterium acnes-derived insoluble immune complexes in sinus macrophages of lymph nodes affected by sarcoidosis. | propionibacterium acnes is thought to be a causative agent of sarcoidosis. patients with sarcoidosis have circulating immune complexes. we attempted to detect p. acnes-derived immune complexes in sarcoid lesions. | 2018 | 29401490 |
| anaerobic bacterial meningitis in adults. | anaerobic infection is a very uncommon condition in adult bacterial meningitis (abm), and its clinical characteristics have yet to be clarified. we enrolled 540 patients with culture-proven bacterial meningitis during a study period of 30 years (1986-2015), of whom 13 (2.4%) had anaerobic infections. these 13 patients were eight men and five women, aged 22-77 years. among them, 53.8% (7/13) had a postneurosurgical state as the preceding event, and 79.6% (10/13) had underlying medical conditions ... | 2018 | 29396061 |
| propionibacterium acnes strains differentially regulate the fate of th17 responses in the skin. | agak et al. demonstrate that different strains of propionibacterium acnes, a bacterium colonizing pilosebaceous units in healthy skin and acne, have the ability to induce t helper type 17 cells secreting either ifn-γ or il-10 and exhibiting either pathogenic or protective properties, respectively. this work contributes to growing evidence indicating that the phenotype of t helper type 17 cells is largely dependent on their microbiological environment. | 2018 | 29389326 |
| epidermal growth factor attenuated the expression of inflammatory cytokines in human epidermal keratinocyte exposed topropionibacterium acnes. | while the beneficial effects of topical epidermal growth factor (egf) on wound healing have been repeatedly reported, there are few reports about the effects of egf on inflammatory skin diseases including acne. | 2018 | 29386833 |
| platelet activation and aggregation by the opportunistic pathogen cutibacterium (propionibacterium) acnes. | cutibacterium (propionibacterium) acnes, considered a part of the skin microbiota, is one of the most commonly isolated anaerobic bacteria from medical implants in contact with plasma. however, the precise interaction of c. acnes with blood cells and plasma proteins has not been fully elucidated. herein, we have investigated the molecular interaction of c. acnes with platelets and plasma proteins. we report that the ability of c. acnes to aggregate platelets is dependent on phylotype, with a sig ... | 2018 | 29385206 |
| propionibacterium acnes abundance correlates inversely with staphylococcus aureus: data from atopic dermatitis skin microbiome. | the microbiome may influence disease severity in atopic dermatitis. the skin of atopic dermatitis patients and healthy individuals was sampled in a standardized manner and the microbial composition analysed using next-generation sequencing. optical density measurements were used to investigate bacterial growth under defined conditions in vitro. lesional skin from patients with atopic dermatitis had a higher abundance of s. aureus and reduced quantities of propionibacterium acnes and lawsonella c ... | 2018 | 29379979 |
| propionibacterium acnes suture contamination in arthroscopic rotator cuff repair: a prospective randomized study. | to examine the contamination rate of the anchor-suture and to determine the efficacy of 2 different surgical skin preparation solutions with or without a plastic adhesive drape from suture contamination in arthroscopic rotator cuff repair. | 2018 | 29373294 |
| a profile of propionibacterium acnes resistance and sensitivity at a tertiary dermatological centre in singapore. | propionibacterium acnes (p. acnes) is a key component in the pathogenesis of acne. both topical and oral antibiotics are key therapeutic options. unfortunately, antibiotic resistance is rapidly increasing globally. many countries have reported greater than 50% of p.acnes strains acquiring resistance to topical macrolides1-3. in singapore, antibiotic resistance rates of 8% in 19994rising to 14.9%5in 2007 were reported. we aimed to update the local prevalence of antibiotic resistance and identify ... | 2018 | 29368337 |
| prevalence of propionibacterium acnes in the glenohumeral compared with the subacromial space in primary shoulder arthroscopies. | we hypothesized that the prevalence of propionibacterium acnes in patients undergoing primary shoulder arthroscopy is equal in the glenohumeral space compared with the subacromial space. | 2018 | 29361412 |
| the human skin microbiome. | functioning as the exterior interface of the human body with the environment, skin acts as a physical barrier to prevent the invasion of foreign pathogens while providing a home to the commensal microbiota. the harsh physical landscape of skin, particularly the desiccated, nutrient-poor, acidic environment, also contributes to the adversity that pathogens face when colonizing human skin. despite this, the skin is colonized by a diverse microbiota. in this review, we describe amplicon and shotgun ... | 2018 | 29332945 |
| shunt nephritis: an increasingly unfamiliar diagnosis. | shunt nephritis is a rare, reversible immune-complex mediated complication of csf shunt infection that can progress to end-stage renal disease and even death if diagnosis is delayed. | 2018 | 29325951 |
| propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the tlr2/jnk/mitochondrial-mediated pathway. | evidence suggests that intervertebral disc degeneration (ivdd) can be induced by propionibacterium acnes (p. acnes), although the underlying mechanisms are unclear. in this study, we analyzed the pathological changes in degenerated human intervertebral discs (ivds) infected with p. acnes. compared with p. acnes-negative samples, p. acnes-positive ivds showed increased apoptosis of nucleus pulposus cells (npcs) concomitant with severe ivdd. then, a p. acnes-inoculated ivd animal model was establi ... | 2018 | 29323102 |
| virome and bacteriome characterization of children with pneumonia and asthma in mexico city during winter seasons 2014 and 2015. | acute asthma exacerbations and pneumonia are important causes of morbidity and mortality in children and may coexist in the same children, although symptom overlap may lead to difficulties in diagnosis. microbial and viral diversity and differential abundance of either may play an important role in infection susceptibility and the development of acute and chronic respiratory diseases. | 2018 | 29447223 |
| propionibacterium acnes has low susceptibility to chlorhexidine digluconate. | the skin bacterium propionibacterium acnes has been reported to be responsible for surgical site infections (ssis). skin disinfection before surgery therefore is of the utmost importance in the prevention of ssis caused by skin bacteria. | 2018 | 29447075 |
| preventing infection in shoulder surgery. | although rare, infection after shoulder surgery can represent a devastating complication. infection can negatively affect clinical outcomes, and eradication often requires a protracted treatment course. staphylococcus aureus, staphylococcus epidermidis, and propionibacterium acnes are among the most frequently isolated pathogens. perioperative measures can be implemented to reduce infection risk. here we review various perioperative practices and their efficacy at reducing infection after should ... | 2018 | 29444755 |
| propionibacterium acnesandstaphylococcus epidermidisolecranon bursitis/osteomyelitis: a case involving surgical and antibiotic treatment. | this report describes a 63-year-old generally healthy male with septic olecranon bursitis caused bypropionibacterium acnesthe patient sustained a small laceration after striking the posterior aspect of his left elbow on a metal railing when he was at a public swimming pool. we concluded thatp. acneswas not initially detected because cultures were only kept for 5 days. consequently, initial antibiotic treatment failed.p. acnesandstaphylococcus epidermidisgrew in a subsequent tissue culture. the i ... | 2018 | 29440139 |
| bacteriology and cefuroxime-resistance in endophthalmitis following cataract surgery before and after the introduction of prophylactic intracameral cefuroxime: a retrospective single-centre study. | intracameral cefuroxime as prophylaxis against postoperative endophthalmitis (poe) following cataract surgery was introduced in 1996 at st erik eye hospital. soon after the introduction of intracameral cefuroxime the rate of poe fell dramatically and a shift in the aetiology was noticed. | 2018 | 29432821 |
| dysbiosis of inferior turbinate microbiota is associated with high total ige levels in allergic rhinitis patients. | abnormalities in the human microbiota are associated with the etiology of allergic diseases. although disease site-specific microbiota may be associated with disease pathophysiology, the role of the nasal microbiota is unclear. we sought to characterize the microbiota of the site of allergic rhinitis, inferior turbinate, in subjects with allergic rhinitis (n=20) and healthy controls (n=12), and to examine the relationship of mucosal microbiota with disease occurrence, sensitized allergen number, ... | 2018 | 29426044 |
| topical delivery of erythromycin through cubosomes for acne. | topical delivery is an attractive route for local and systemic treatment. novel topical application has many advantages like avoids the gi-irritation, prevent the metabolism of drug in the liver and increase the bioavailability of the drug over the conventional dosage forms. the aim of present work was to prepared and characterized erythromycin encapsulated cubosomes using different concentration of glyceryl monooleate and poloxamer 407 by emulsification method. the prepared dispersion of cuboso ... | 2018 | 29424323 |
| susceptibility of enterococcus faecalis and propionibacterium acnes to antimicrobial photodynamic therapy. | bacterial resistance to available antibiotics nowadays is a global threat leading researchers around the world to study new treatment modalities for infections. antimicrobial photodynamic therapy (apdt) has been considered an effective and promising therapeutic alternative in this scenario. briefly, this therapy is based on the activation of a non-toxic photosensitizing agent, known as photosensitizer (ps), by light at a specific wavelength generating cytotoxic singlet oxygen and free radicals. ... | 2018 | 29253813 |
| acne in late adolescence and risk of prostate cancer. | accumulating evidence suggest that propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. the aim of this population-based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. we identified a large cohort of young men born in sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the ag ... | 2018 | 29205339 |
| detection of bacteria colonizing titanium spinal implants in children. | bacterial colonization of spinal implants may cause severe complications in patients with early-onset scoliosis. correct diagnosis and detection of microbiologic formation is crucial to prevent delayed infections caused by bacterial colonization. the purposes of this study were to estimate the rate and risk factors of colonization of vertical expandable prosthetic titanium rib (veptr) implants in children and to compare the different methods for detecting microbiologic formation on the spinal im ... | 2018 | 29190173 |
| bacterial colonisation of suture material after routine neurosurgical procedures: relevance for wound infection. | wound healing impairment is a serious problem in surgical disciplines which may be associated with chronic morbidity, increased cost and patient discomfort. here we aimed to investigate the relevance of bacterial colonisation on suture material using polymerase chain reaction (pcr) to detect and taxonomically classify bacterial dna in patients with and without wound healing problems after routine neurosurgical procedures. | 2018 | 29189910 |
| microbiology alloplastic total joint infections: a 20-year retrospective study. | prosthetic joint infection (pji) is a rare complication of temporomandibular joint replacement (tjr). this study evaluated tjr pjis at the authors' institution over a 20-year period, including micro-organisms cultured, antibiotic resistance patterns, and intraoperative protocols of tjr. | 2018 | 29178982 |
| perioperative antibiotic prophylaxis has no effect on time to positivity and proportion of positive samples: a cohort study of 64 cutibacterium acnes bone and joint infections. | if a bone or joint infection is suspected, perioperative antibiotic prophylaxis is frequently withheld until intraoperative microbiological sampling has been performed. this practice builds upon the hypothesis that perioperative antibiotics could render culture results negative and thus impede tailored antibiotic treatment of infections. we aimed to assess the influence of antibiotic prophylaxis within 30 to 60 min before surgery on time to positivity of microbiological samples and on proportion ... | 2018 | 29167293 |
| decrease in diversity of propionibacterium acnes phylotypes in patients with severe acne on the back. | propionibacterium acnes, a major member of normal skin microbiota, is subdivided into 6 phylotypes: ia1, ia2, ib, ic, ii and iii. this study investigated p. acnes subgroups on the face and back in patients with severe acne and in healthy controls. in 71.4% of patients with severe acne, p. acnes phylotypes were identical on the face and back, whereas this was the case in only 45.5% of healthy controls. the healthy group carried phylotypes ia1 (39.1%) and ii (43.4%), whereas the acne group carried ... | 2018 | 29136261 |
| on revealing the gene targets of ebola virus micrornas involved in the human skin microbiome. | ebola virus, a negative-sense single-stranded rna virus, causes severe viral hemorrhagic fever and has a high mortality rate. histopathological and immunopathological analyses of ebola virus have revealed that histopathological changes in skin tissue are associated with various degrees of endothelial cell swelling and necrosis. the interactions of microbes within or on a host are a crucial for the skin immune shield. the discovery of micrornas (mirnas) in ebola virus implies that immune escape, ... | 2018 | 29312814 |
| the antimicrobial effect of cen1hc-br against propionibacterium acnes and its therapeutic and anti-inflammatory effects on acne vulgaris. | propionibacterium acnes is a commensal bacterium, which is involved in acne inflammation. an antimicrobial peptide named cen1hc-br, which was isolated and characterized form the green sea urchin, has been shown to possess broad-spectrum antibacterial activity. little is known concerning the potential effects of its antibacterial and anti-inflammatory properties against p. acnes. to examine the potency of cen1hc-br in acne treatment, we conducted experiments to analyze the antibacterial and anti- ... | 2018 | 29108811 |
| detection of clinical cutibacterium acnes isolates in different becton dickinson blood culture vials. | 2018 | 29093107 | |
| medicinal mascarene aloes: an audit of their phytotherapeutic potential. | a phytochemical and biological investigation of the endemic mascarene aloes (aloe spp.), including a. tormentorii (marais) l.e.newton & g.d.rowley, a. purpurea lam, a. macra haw., a. lomatophylloides balf.f and a. vera (synonym a. barbadensis mill.), which are used in the traditional folk medicine of the mascarene islands, was initiated. methanolic extracts of the aloes under study were analysed using high resolution lc-uv-ms/ms and compounds belonging to the class of anthraquinones, anthrones, ... | 2018 | 29066297 |
| targeted sequencing of clade-specific markers from skin microbiomes for forensic human identification. | the human skin microbiome is comprised of diverse communities of bacterial, eukaryotic, and viral taxa and contributes millions of additional genes to the repertoire of human genes, affecting human metabolism and immune response. numerous genetic and environmental factors influence the microbiome composition and as such contribute to individual-specific microbial signatures which may be exploited for forensic applications. previous studies have demonstrated the potential to associate skin microb ... | 2018 | 29065388 |
| performance of implant sonication culture for the diagnosis of periprosthetic shoulder infection. | diagnosing infection after shoulder arthroplasty can be a challenge because of the high prevalence of low-virulence organisms, such as propionibacterium acnes. the purpose of this study was to evaluate the utility of implant sonication fluid cultures in the diagnosis of periprosthetic joint infection compared with standard culture techniques in patients undergoing revision shoulder arthroplasty. | 2018 | 29037535 |
| colonization of oropharynx and lower respiratory tract in critical patients: risk of ventilator-associated pneumonia. | to investigate the microbial diversity existing in oral cavity and respiratory tract samples (from mini-bronchoalveolar lavage (bal), endotracheal aspirate, and orotracheal tube) of patients on mechanical ventilation by using the checkerboard dna-dna hybridisation. also, the study aimed to evaluate whether the microbial profile in the oral cavity is found in respiratory tract samples, at different periods of mechanical ventilation time (12h, 48h, 96h) in attempt to identification of relationship ... | 2018 | 29031240 |
| targeted intervention of acute postoperative infection after rotator cuff repair results in good functional outcomes. | the primary goal of this retrospective review of a prospective database was to document the functional results after acute postoperative deep infection following rotator cuff repair in a single orthopaedic unit over a period of 5 years. secondary goals were to document the effect of infection on healing of the cuff repair and to describe its incidence, diagnostic challenges, pathogens and management. | 2018 | 29022059 |
| propionibacterium avidum: a virulent pathogen causing hip periprosthetic joint infection. | propionibacteria are important members of the human skin microbiota, but are also opportunistic pathogens associated with periprosthetic joint infection (pji). while the role of propionibacterium acnes in pji has been widely described, insight into the capacity of propionibacterium avidum to cause pji is limited. | 2018 | 29020266 |
| propionibacterium acnes as an emerging pathogen in skull base osteomyelitis: a case series. | skull base osteomyelitis (sbo) is recognized as a potentially life-threatening infection that has been classically attributed to pseudomonas aeruginosa. however, growing data shows that the bacteriology of sbo is changing. traditionally thought of as commensal bacterium, p. acnes has been implicated as a serious pathogen in other specialties. building on a previous case report from our institution, we have identified three patients with sbo who are culture-positive for propionibacterium acnes as ... | 2018 | 28994125 |
| contamination occurs during acl graft harvesting and manipulation, but it can be easily eradicated. | why anterior cruciate ligament (acl) autograft soaking in a 5 mg/ml vancomycin solution decreases the rate of infection has not been well-explained. one hypothesis is that grafts can be contaminated during harvesting and vancomycin eradicates the bacteria. the purpose of the present study is to assess how the vancomycin solution acts against acl graft contamination during graft harvesting and preparation. | 2018 | 28988312 |
| glucocorticoids and toll-like receptor 2 cooperatively induce acute-phase serum amyloid a. | serum amyloid a (saa) is a highly conserved acute-phase protein and extrahepatic produced saa1/2 contributes to cutaneous inflammation. prolonged systemic or topical treatment with glucocorticoids can provoke skin diseases such as steroid-induced acne. glucocorticoids increase toll-like receptor 2 (tlr2) expression, however, an inflammatory mediator linked to this side effect remains elusive. we report that tlr2 agonists in combination with dexamethasone substantially increase saa expression and ... | 2018 | 28941781 |
| tanycytic ependymoma of the brain stem, presentations of rare cystic disease variants and review of literature. | the aim of this paper was to systematically review the evidence linking propionibacterium acnes (p. acnes) with the develop tanycytic ependymoma (tce) is a rare variant of ependymoma and management guidelines for patients with this disease are not established. | 2018 | 28884561 |
| phenotype and antimicrobial activity of th17 cells induced by propionibacterium acnes strains associated with healthy and acne skin. | studies of the human skin microbiome suggest that propionibacterium acnes strains may contribute differently to skin health and disease. however, the immune phenotype and functions of t helper type 17 (th17) cells induced by healthy (ph) versus acne (pa) skin-associated p. acnes strains are currently unknown. we stimulated peripheral blood mononuclear cells from healthy donors and observed that pastrains induce higher il-17 levels than phstrains. we next generated phand pastrain-specific th17 cl ... | 2018 | 28864077 |
| effectiveness of meibomian gland massage combined with topical levofloxacin against ocular surface flora in patients before penetrating ocular surgery. | to investigate the bacterial profile in the conjunctiva and meibomian glands in patients before penetrating ocular surgeries, and to compare the anti-bacterial efficacy of 0.5% levofloxacin and its combination with meibomian gland massage. | 2018 | 28890180 |
| bacterial conjugated linoleic acid production and their applications. | conjugated linoleic acid (cla) has been shown to exert various potential physiological properties including anti-carcinogenic, anti-obesity, anti-cardiovascular and anti-diabetic activities, and consequently has been considered as a promising food supplement. bacterial biosynthesis of cla is an attractive approach for commercial production due to its high isomer-selectivity and convenient purification process. many bacterial species have been reported to convert free linoleic acid (la) to cla, h ... | 2017 | 28889933 |
| forensic human identification using skin microbiomes. | the human microbiome contributes significantly to the genetic content of the human body. genetic and environmental factors help shape the microbiome, and as such, the microbiome can be unique to an individual. previous studies have demonstrated the potential to use microbiome profiling for forensic applications, however a method has yet to identify stable features of skin microbiomes that produce high classification accuracies for samples collected over reasonably long time intervals. a novel ap ... | 2017 | 28887423 |
| immune discrepancies during in vitro granuloma formation in response to cutibacterium (formerly propionibacterium) acnes infection. | cutibacterium (formerly propionibacterium) acnes is involved in chronic/low-grade pathologies such as sarcoidosis or prosthetic joint infection (pji). in these diseases, granulomatous structures are frequently observed. in this study, we induced a physiological granulomatous reaction in response to different well-characterized clinical c. acnes isolates in order to investigate the cellular process during granuloma formation. three c. acnes isolates selected according to their origin (pji, sarcoi ... | 2017 | 28859990 |
| propionibacterium acnes infection in the native hip: a case report. | a sixty-five-year-old immunocompetent man with bilateral osteonecrosis of the hip and no prior surgical procedures or trauma was found to have a subacute propionibacterium acnes infection of the femoral head. to our knowledge, this is the first reported case of propionibacterium acnes infection in a native hip in the orthopaedic literature. | 2017 | 29252848 |
| inflammatory response of disc cells against propionibacterium acnes depends on the presence of lumbar modic changes. | intervertebral disc with propionibacterium acnes (p. acnes) is suggested to be an etiology of modic type i changes in the adjacent bone marrow. however it is unknown if disc cells can respond to p. acnes and if bone marrow cells respond to bacterial and disc metabolites draining from infected discs. | 2017 | 28884220 |
| acute exacerbation of organizing pneumonia leading to sudden death in a patient with sarcoidosis-lymphoma syndrome. | the subject was an 83-year-old female; she had a history of propionibacterium acnes-related sarcoidosis at the age of 79 years. at diagnosis, she was treated with clarithromycin and achieved remission. four years later, during a routine physical check-up, she presented with pulmonary opacities and swelling of multiple lymph nodes. a definitive diagnosis of lymphoma could not be made by inguinal lymph node biopsy. the patient's general condition was good, and we observed her clinical course. oh t ... | 2017 | 28883276 |
| comparative effects of schisandrin a, b, and c on acne-related inflammation. | inflammatory responses induced by propionibacterium acnes are a major etiological factor in the pathogenesis of acne vulgaris. schisandrin a, schisandrin b, and schisandrin c are the representative lignans of schisandra chinensis (turcz.) baill. extract. although anti-inflammatory effects of the lignans have been shown, their effects on acne-related inflammation caused by p. acnes have not been investigated and compared. we pretreated thp-1 human monocytic cells with 5, 10, and 20 μm schisandrin ... | 2017 | 28875271 |
| postoperative deep shoulder infections following rotator cuff repair. | rotator cuff repair (rcr) is one of the most commonly performed surgical procedures in orthopaedic surgery. the reported incidence of deep soft-tissue infections after rcr ranges between 0.3% and 1.9%. deep shoulder infection after rcr appears uncommon, but the actual incidence may be higher as many cases may go unreported. clinical presentation may include increasing shoulder pain and stiffness, high temperature, local erythema, swelling, warmth, and fibrinous exudate. generalized fatigue and s ... | 2017 | 28875126 |
| routine cultures for seemingly aseptic revision shoulder arthroplasty: are they necessary? | propionibacterium acnes has recently gained attention as the leading cause of periprosthetic joint infections (pjis) after shoulder arthroplasty. unlike pjis in the lower extremity, pjis after shoulder arthroplasty usually have an indolent course and are notoriously difficult to diagnose. most of the time, the diagnosis is made after positive intraoperative cultures are taken at the time of revision surgery. adding even more complexity to the diagnosis is the high rate of p acnes-positive cultur ... | 2017 | 28865964 |
| an anti-propionibacterium acnes antibody shows heterologous resistance to an actinobacillus pleuropneumoniae infection independent of neutrophils in mice. | porcine contagious pleuropneumonia is a highly fatal respiratory disease that is caused by actinobacillus pleuropneumoniae (app) and results in tremendous economic losses for the pig breeding industry worldwide. previous studies have demonstrated that propionibacterium acnes (pa) could effectively prevent app infection in mice and pigs. the humoral immune response played a primary role during this process and anti-pa antibody could mediate macrophages to kill the bacteria. however, the role of n ... | 2017 | 28929313 |
| propionibacterium acnes. | infection after implantation of ventriculo-peritoneal (vp) shunts is associated with significant morbidity and mortality. we describe a 9-year-old girl with propionibacterium acnes shunt infection with negative cerebrospinal fluid cultures, diagnosed by broad-range 16s-rrna gene pcr. this case supports the use of this molecular diagnostic technique in shunt infections, where the offending pathogens are difficult to culture using traditional methods. | 2017 | 28902005 |
| the skin bacterium propionibacterium acnes employs two variants of hyaluronate lyase with distinct properties. | hyaluronic acid (ha) and other glycosaminoglycans are extracellular matrix components in the human epidermis and dermis. one of the most prevalent skin microorganisms,propionibacterium acnes, possesses ha-degrading activity, possibly conferred by the enzyme hyaluronate lyase (hyl). in this study, we identified the hyl ofp. acnesand investigated the genotypic and phenotypic characteristics. investigations include the generation of ap. acneshylknockout mutant and hyl activity assays to determine t ... | 2017 | 28895889 |
| cationic peptides from peptic hydrolysates of rice endosperm protein exhibit antimicrobial, lps-neutralizing, and angiogenic activities. | in this study, we hydrolyzed rice endosperm protein (rep) with pepsin and generated 20 fractions containing multifunctional cationic peptides with varying isoelectric point (pi) values using ampholyte-free isoelectric focusing (autofocusing). subsequently, we determined antimicrobial activities of each fraction against the pathogens prophyromonas gingivalis, propionibacterium acnes, streptocossus mutans, and candida albicans. fractions 18, 19, and 20 had pi values greater than 12 and exhibited a ... | 2017 | 28987278 |
| what is the role of the bacterium propionibacterium acnes in type 1 modic changes? a review of the literature. | this review presents a summary of the pathology and epidemiology of modic changes and the possible role of propionibacterium acnes. this information is followed by a synthesis of the most recent clinical research involved in culturing the discs of patients with degenerative disc disease for the presence of bacteria. we also discuss a randomized controlled trial that investigates the effects of antibiotics on patients with chronic low back pain and type 1 modic changes. we conclude with a brief d ... | 2017 | 28985974 |
| comparative effects of schisandrin a, b, and c on propionibacterium acnes-induced, nlrp3 inflammasome activation-mediated il-1β secretion and pyroptosis. | propionibacterium acnes, a common pathogen associated with acne, is also responsible for various surgical infections. schisandrin a, schisandrin b and schisandrin c, the representative lignans of schisandra chinensis (turcz.) baill. extract, inhibit p. acnes-induced inflammation. however, their effects on p. acnes-induced il-1β secretion and pyroptosis mediated by nlrp3 inflammasome activation remain unknown. in this study, we compared the effects of schisandrin a, b, and c (sch a, b, and c) on ... | 2017 | 28972885 |
| impact of sequential culture results on diagnosis and de-escalation of the antibiotic regimen in joint and bone infections. | according to existing guidelines, orthopedic specimens collected in joint and bone infections (jbi) in our institution are cultured on several media sets and incubated for two, seven, and 14 days. the optimal timing for de-escalation of the first-line antibiotic combination according to the culture results needs to be defined. | 2017 | 28972874 |
| in vitroactivities of pexiganan and 10 comparator antimicrobials against 502 anaerobic isolates recovered from skin and skin structure infections. | pexiganan, a cationic peptide, exhibited a broad range of anti-anaerobic antimicrobial activity. the mic90s of studied isolates were as follows:bacteroides fragilis, 16 μg/ml; otherb. fragilisgroup spp., 4 μg/ml;prevotellaandfusobacteriumspp., 32 μg/ml;porphyromonasspp., 64 μg/ml;propionibacterium acnes, 4 μg/ml;eggerthella lentaandpeptostreptococcus anaerobius, 32 μg/ml; other gram-positive rods and cocci, 4 μg/ml;clostridium perfringens, 128 μg/ml; and other clostridia, 256 μg/ml. pexiganan cr ... | 2017 | 28993327 |
| clinical and microbiological profile of infectious keratitis in an area of madrid, spain. | to study antibiotic susceptibility in bacterial keratitis (bk), its profile over 10 years and its influence on ophthalmological practice. | 2017 | 28993066 |
| long-term effects of cataract surgery with topical levofloxacin on ocular bacterial flora. | to clarify the long-term effect of topical antibiotics on the ocular bacterial flora after cataract surgery. | 2017 | 28991607 |
| constrictive pericarditis caused by cutibacterium (propionibacterium) acnes: a case report and review of literature. | constrictive and effusive-constrictive pericarditis are rare cardiac disorders. only rarely are the conditions caused by purulent infection, and even more infrequently by anaerobe bacteria. we describe a case of constrictive - and effusive-constrictive pericarditis due tocutibacterium (formerlypropionibacterium) acnesin a 75-year old, immunocompetent and previously healthy patient without any predisposition. the patient was successfully treated with subtotal pericardiectomy and beta-lactam antib ... | 2017 | 29021959 |
| [persistent extra-axial post-surgical collections and propionibacterium acnes infection. presentation of two cases and literature review]. | it is common to observe the persistence of extra-axial collections after craniotomies. most of these disappear in weeks or months but some remain. the onset of focal symptoms or the growth of these persistent collections months or years after surgery may indicate the presence of a chronic and latent infection by germs of low virulence such as propionibacterium acnes (p. acnes). | 2017 | 29033263 |
| computed tomography fistulography of the sternum. a case report on interprofessional collaboration between radiologist and surgeon. | trans sternal fistula can occur after sternotomy/heart surgery. diagnosing this can be difficult. | 2017 | 29055879 |
| draft genome sequences of three multidrug-resistant cutibacterium (formerly propionibacterium) acnes strains isolated from acne patients, china. | cutibacterium acnes (formerly propionibacterium acnes), an anaerobic gram-positive bacterium, is a skin commensal and is considered to be associated with acne. here we report the draft genome sequences of three multidrug-resistant (mdr) c. acnes strains (ca17, ca39 and ca51) isolated from skin lesions of acne patients in china. | 2017 | 29051020 |
| association between chronic inflammation and latent infection of propionibacterium acnes in non-pyogenic degenerated intervertebral discs: a pilot study. | propionibacterium acnes may be considered a new pathogeny for disc degeneration, but its pathological role has remained unclear. this study was designed to determine whether the latent infection of p. acnes was associated with chronic inflammation in degenerated intervertebral discs via quantification of the levels of a series of cytokines and neutrophils. | 2017 | 29086028 |
| [diet in pathogenesis of acne vulgaris]. | acne vulgaris is one of the most common dermatologic condition especially among adolescents. acne is related to excess sebum production by sebaceous glands, inflammation both within and adjacent to the comedones, hyperproliferation of propionibacterium acnes. some of investigations show association between acne and diet. milk increases the level of igf-1 leading to the synthesis of androgen-mediated increases sebum production. chocolate predispose to hyperglycemia and insulinemia which aggravate ... | 2017 | 29084194 |
| antibacterial activity of gold nanorods againststaphylococcus aureusandpropionibacterium acnes: misinterpretations and artifacts. | the antibacterial activity of gold nanorod (gnr) suspensions of different surface functionalities was investigated against standard strains ofstaphylococcus aureusandpropionibacterium acnes, taking into consideration two commonly "overlooked" factors: the colloidal stability of gnr suspensions upon mixing with bacterial growth media and the possible contribution of "impurities/molecules" in gnr suspensions to the observed antibacterial activity. the results demonstrated that cationic polyallylam ... | 2017 | 29070948 |
| in-vitro evaluation of marine derived fungi against cutibacterium acnes. | cutibacterium acnes (or propionibacterium acnes) is the main target for the prevention and medical treatment of acne vulgaris. the aim of this study was to evaluate the in vitro anti-c. acnes and anti-s. epidermidis properties of some marine fungi isolated from different indian marine environments. seventy fungal isolates were obtained from samples collected from the west coasts and andaman island, india. methanol extracts of 35 isolates were screened for their antibacterial properties and 5 out ... | 2017 | 29100929 |
| low-level red led light inhibits hyperkeratinization and inflammation induced by unsaturated fatty acid in an in vitro model mimicking acne. | acne vulgaris is a chronic inflammatory disease of the pilosebaceous units (psu), associated with increased sebum production, abnormal follicular keratinization (hyperkeratinization), follicular overgrowth of propionibacterium acnes (p. acnes), and increased inflammatory mediator release. light therapy has attracted medical interests as a safe alternative treatment for acne. both blue and red light therapies at high doses >10 j/cm2have demonstrated marked effects on inflammatory acne lesions. ho ... | 2017 | 29095531 |
| over a decade of reca and tly gene sequence typing of the skin bacterium propionibacterium acnes: what have we learnt? | the gram-positive, anaerobic bacteriumpropionibacterium acnesforms part of the normal microbiota on human skin and mucosal surfaces. while normally associated with skin health,p. acnesis also an opportunistic pathogen linked with a range of human infections and clinical conditions. over the last decade, our knowledge of the intraspecies phylogenetics and taxonomy of this bacterium has increased tremendously due to the introduction of dna typing schemes based on single and multiple gene loci, as ... | 2017 | 29267255 |
| corrigendum: proposal to reclassify propionibacterium acnes type i as propionibacterium acnes subsp. acnes subsp. nov. and propionibacterium acnes type ii as propionibacterium acnes subsp. defendens subsp. nov. | 2017 | 29130432 | |
| cutibacterium (formerly propionibacterium) acnes infections associated with implantable devices. | cutibacterium acnes (c. acnes), a gram-positive biofilm-forming rod implicated in acne vulgaris, is increasingly recognized for its role in implant-associated infections. the diagnosis of c. acnes implant-associated infections remains challenging. the optimal treatment is a combination of both surgical intervention and antibiotic therapy. areas covered: in this review, we discuss the different types of implant-associated infections caused by c. acnes. we also highlight the clinical manifestation ... | 2017 | 29125405 |
| immunohistochemical detection of propionibacterium acnes in the retinal granulomas in patients with ocular sarcoidosis. | the etiology of sarcoidosis is still obscure; however, mycobacteria and propionibacterium acnes are considered the most implicated etiological agent for sarcoidosis. to investigate whether p. acnes is an etiological agent for sarcoid uveitis, we analyzed the frequency of p. acnes detected within the biopsied retinas from patients with ocular sarcoidosis by immunohistochemistry with a p. acnes-specific monoclonal antibody (pab antibody). eleven patients (12 eyes) with sarcoid uveitis were enrolle ... | 2017 | 29123243 |
| identification of low oxygen-tolerating bacteria in prostate secretions of cancer patients and discussion of possible aetiological significance. | the microaerophylic organism propionibacterium acnes has shown consistent association with prostate cancer (pc). studies linking circumcision with reduced pc further support anaerobes involvement as circumcision reduces anaerobe colonisation on the glans penis. a 1988 study linked anaerobes with pc but considered them as opportunists in necrotic tumour. a hypothesis that a "helicobacter-like" process causes pc justified this pilot study. active surveillance patients were enrolled. post-prostate ... | 2017 | 29123122 |
| diversity of bacterial communities on the facial skin of different age-group thai males. | skin microbiome varies from person to person due to a combination of various factors, including age, biogeography, sex, cosmetics and genetics. many skin disorders appear to be related to the resident microflora, yet databases of facial skin microbiome of many biogeographies, including thai, are limited. | 2017 | 29177119 |
| developing an in vitro artificial sebum model to study propionibacterium acnes biofilms. | the aim of the present study was to develop a new model system to study propionibacterium acnes biofilms. this model should be representative for the conditions encountered in the pilosebaceous unit. | 2017 | 29175428 |
| cp and cp-pgn protect mice against mrsa infection by inducing m1 macrophages. | corynebacterium pyruviciproducens (c. pyruviciproducens, cp), as a newly discovered immunomodulator, has been confirmed to have a stronger immunoregulation than propionibacterium acnes (p. acnes) of the traditional immune adjuvant, by previous experiments with model antigen ovalbumin and sheep red blood cells. here, it was designed to assess its ability to resist methicillin-resistant staphylococcus aureus (mrsa), since mrsa as a vital gram positive pathogen is characterized by high morbidity an ... | 2017 | 29203871 |
| prevalence of flp pili-encoding plasmids incutibacterium acnesisolates obtained from prostatic tissue. | inflammation is one of the hallmarks of prostate cancer. the origin of inflammation is unknown, but microbial infections are suspected to play a role. in previous studies, the gram-positive, low virulent bacteriumcutibacterium(formerlypropionibacterium)acneswas frequently isolated from prostatic tissue. it is unclear if the presence of the bacterium represents a true infection or a contamination. here we investigatedcutibacterium acnestype ii, also called subspeciesdefendens, which is the most p ... | 2017 | 29201018 |
| g2a attenuatespropionibacterium acnesinduction of inflammatory cytokines in human monocytes. | acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses topropionibacterium acnes(pa). here, we explore a possible mechanism by which a lipid receptor, g2a, regulates immune responses to a commensal bacterium. | 2017 | 29200756 |
| propionibacterium acnes induces autophagy in keratinocytes: involvement of multiple mechanisms. | propionibacterium acnes is a dominant member of the cutaneous microbiota. herein, we evaluate the effects of different p. acnes strains and propionic acid on autophagy in keratinocytes. our results showed that p. acnes strain 889 altered the architecture of the mitochondrial network, elevated the levels of lc3b-ii, beclin-1 and phospho-ampkα, stimulated autophagic flux, facilitated intracellular redistribution of lc3b, increased average number of autophagosomes per cell, and enhanced development ... | 2017 | 29191621 |
| photodynamic action of the red laser on propionibacterium acnes. | photodynamic therapy is a therapeutic modality that has consolidated its activity in the photooxidation of organic matter, which arises from the activity of reactive oxygen species. | 2017 | 29166495 |
| subclinical propionibacterium acnes infection estimation in the intervertebral disc (spine-id): protocol for a prospective cohort. | low back pain and vertebral endplate abnormalities are common conditions within the population. subclinical infection caused by indolent pathogens can potentially lead to these findings, with differentiation between them notably challenging from a clinical perspective. progressive infection of the intervertebral disc has been extensively associated with increasing low back pain, with propionibacterium acnes specifically implicated with in relation to sciatica. the main purpose of this study is t ... | 2017 | 29151051 |
| skin barrier and microbiome in acne. | acne is an immune-mediated chronic inflammatory disease. although several factors are involved in its pathophysiology, this process is not completely understood. androgen hormone activity increases sebum production inside the pilosebaceous follicle, adjusting the environment for the development of propionibacterium acnes which triggers inflammation. knowing how others factors such as the skin barrier and microbiome are involved in acne, can help in understanding more about the disease and may he ... | 2017 | 29147769 |
| [periodontal microbiota and microorganisms isolated from heart valves in patients undergoing valve replacement surgery in a clinic in cali, colombia]. | periodontitis is an infectious disease that affects the support tissue of the teeth and it is associated with different systemic diseases, including cardiovascular disease. microbiological studies facilitate the detection of microorganisms from subgingival and cardiovascular samples. | 2017 | 29373772 |
| periprosthetic joint infection of shoulder arthroplasties: diagnostic and treatment options. | periprosthetic joint infection (pji) is one of the most frequent reasons for painful shoulder arthroplasties and revision surgery of shoulder arthroplasties.cutibacterium acnes (propionibacterium acnes)is one of the microorganisms that most often causes the infection. however, this slow growing microorganism is difficult to detect. this paper presents an overview of different diagnostic test to detect a periprosthetic shoulder infection. this includes nonspecific diagnostic tests and specific te ... | 2017 | 29423407 |
| [progress on propionibacterium acnes and degenerative intervertebral disc]. | the mechanism of degenerative intervertebral disc is very complex, which may be associated with multiple factors such as the mechanical stress force injury of intervertebral disc, nutritional deficiency, inflammatory stimulation, etc. recently, many studies detected propionibacterium acnes(p. acnes) in degenerative intervertebral disc and supposed p. acnes was associated with degenerative intervertebral disc. here, the papers related to p. acnes and degenerative intervertebral disc were reviewed ... | 2017 | 29417784 |
| glenohumeral joint sepsis after joint injection through a new tattoo. | we report a case of propionibacterium acnes septic arthritis of a shoulder following two joint access procedures. methodical investigation of these two procedures was performed using the joint commission root cause analysis matrix, which involved examination of protocols, interviews with technologists and physicians, and inspection of the procedure rooms and equipment. no procedural error or other causal factor for infection was found other than the injection through a five day-old tattoo during ... | 2017 | 29296168 |
| a case of relapsing polychondritis mimicking hemophagocytic lymphohistiocytosis after propionibacterium acnes infection. | we describe a 69-year-old man who presented with a right sternocleidomastoid intramuscular abscess that grew propionibacterium acnes. despite initial improvement with antibiotics, he subsequently developed signs and symptoms fulfilling diagnostic criteria for hemophagocytic lymphohistiocytosis (hlh)-fevers, cytopenias, hyperferritinemia, splenomegaly, and low natural killer cell activity. the patient improved spontaneously but at outpatient follow-up complained of erythema over the bridge of his ... | 2017 | 29280824 |
| bacterial diversity in feline conjunctiva based on 16s rrna gene sequence analysis: a pilot study. | changes in the microbial populations in the conjunctival sacs of animals have traditionally been evaluated using conventional microbiology techniques. the goal of this study was to examine the suitability of a methodology which may reveal a previously unknown microbiome inhabiting feline conjunctival membranes. in the present study, we determined the microbial diversity in feline conjunctivas based on 16s rrna gene sequence analysis. five taxa not described earlier in veterinary ophthalmology (i ... | 2017 | 29279847 |
| topographical diversity of common skin microflora and its association with skin environment type: an observational study in chinese women. | this study evaluated cutaneous microbial distribution, and microbial co-occurrence at different body sites and skin environments in chinese women (39.6 ± 11.9 years, n = 100) during the winter season. microbial distribution (propionibacterium acnes, staphylococcus aureus, staphylococcus epidermidis, lactobacillus, pseudomonadaceae, and malassezia furfur), association with biomarkers (antimicrobial peptides: ll-37, β-defensins [hbd-2, hbd-3]), and claudin-1) and skin biophysical parameters (trans ... | 2017 | 29273721 |
| infection rate after cranial neurosurgical procedures: a prospective single-center study. | to determine infection rate (ir) and to identify modifiable risk factors (rf) in cranial neurosurgery in a neurosurgical department for tertiary referral as part of an infection control surveillance to reduce surgical site infections (ssi). | 2017 | 29269070 |
| culture-dependent approaches to explore the prevalence of root canal pathogens from endodontic infections. | endodontic infections are considered to be caused by the presence of various microorganisms within the root canal system. recognition of this microbiota contributes to the successful treatment of infected root canals. this study investigated the microorganisms associated with primary and secondary endodontic infections via culture methods, biochemical tests, and molecular approaches in an iranian population. microbial specimens were collected from 36 patients with primary endodontic infection an ... | 2017 | 29267669 |
| disseminated propionibacterium acnes infection in a 42-year-old hiv-positive man. | 2017 | 29241870 | |
| long-term administration of oral macrolides for acne treatment increases macrolide-resistant propionibacterium acnes. | macrolide-resistant propionibacterium acnes are frequently isolated from patients with acne vulgaris, and the most resistant isolates (>90% resistance) have the 23s rrna mutation. an increase in resistant p. acnes with this mutation is thought to be caused by the inappropriate use of antimicrobials. therefore, we studied the mutation frequency of macrolide resistance in p. acnes in vitro. when p. acnes mutants were exposed to clarithromycin after being incubated in broth without antimicrobials, ... | 2017 | 29235673 |
| antibiotic treatment of propionibacterium acnes endocarditis. | 2017 | 28782652 | |
| fast 2d nmr spectroscopy for in vivo monitoring of bacterial metabolism in complex mixtures. | the biological toolbox is full of techniques developed originally for analytical chemistry. among them, spectroscopic experiments are very important source of atomic-level structural information. nuclear magnetic resonance (nmr) spectroscopy, although very advanced in chemical and biophysical applications, has been used in microbiology only in a limited manner. so far, mostly one-dimensional (1)h experiments have been reported in studies of bacterial metabolism monitored in situ. however, low sp ... | 2017 | 28769889 |
| the colonisation of the glenohumeral joint by propionibacterium acnes is not associated with frozen shoulder but is more likely to occur after an injection into the joint. | our aim was to investigate the prevalence of propionibacterium (p.) acnes in the subcutaneous fat and capsule of patients undergoing shoulder surgery for frozen shoulder or instability. | 2017 | 28768784 |