Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| systemic bartonella henselae infection and crohn's disease treatment with infliximab. | 2012 | 21928372 | |
| bartonella infection in immunocompromised hosts: immunology of vascular infection and vasoproliferation. | most infections by genus bartonella in immunocompromised patients are caused by b. henselae and b. quintana. unlike immunocompetent hosts who usually develop milder diseases such as cat scratch disease and trench fever, immunocompromised patients, including those living with hiv/aids and posttransplant patients, are more likely to develop different and severe life-threatening disease. this paper will discuss bartonella's manifestations in immunosuppressed patients and will examine bartonella's i ... | 2012 | 22162717 |
| Transmission of flea-borne zoonotic agents (*). | Flea-borne zoonoses such as plague (Yersinia pestis) and murine typhus (Rickettsia typhi) caused significant numbers of human cases in the past and remain a public health concern. Other flea-borne human pathogens have emerged recently (e.g., Bartonella henselae, Rickettsia felis), and their mechanisms of transmission and impact on human health are not fully understood. Our review focuses on the ecology and epidemiology of the flea-borne bacterial zoonoses mentioned above with an emphasis on rece ... | 2012 | 21888520 |
| Prevalence of antibodies anti-bartonella henselae in Western sicily: children, blood donors, and cats. | To evaluate seroprevalence of B. henselae infection both in Sicilian children and healthy blood donors. Furthermore, circulation of Bartonella in the natural reservoir was also studied. Two hundred forty-three children, living in Sicily (Palermo), affected by various diseases, without clinical features suggesting B. henselae infection, together with 122 healthy blood donors were serologically investigated for IgG and IgM antibodies by indirect fluorescent antibody test (IFAT). One hundred twenty ... | 2012 | 22181817 |
| persistence of bartonella spp. stealth pathogens: from sub-clinical infections to vasoproliferative tumour formation. | bartonella spp. are facultative intracellular bacteria that typically cause a long-lasting intraerythrocytic bacteremia in their mammalian reservoir hosts, thereby favoring transmission by blood-sucking arthropods. in most cases, natural reservoir host infections are subclinical and the relapsing intraerythrocytic bacteremia may last weeks, months or even years. in this review, we will follow the infection cycle of bartonella spp. in a reservoir host, which typically starts with an intradermal i ... | 2012 | 22229763 |
| adenylylation control by intra- or intermolecular active-site obstruction in fic proteins. | fic proteins that are defined by the ubiquitous fic (filamentation induced by cyclic amp) domain are known to catalyse adenylylation (also called ampylation); that is, the transfer of amp onto a target protein. in mammalian cells, adenylylation of small gtpases through fic proteins injected by pathogenic bacteria can cause collapse of the actin cytoskeleton and cell death. it is unknown how this potentially deleterious adenylylation activity is regulated in the widespread fic proteins that are f ... | 2012 | 22266942 |
| granulomatous hepatitis due to bartonella henselae infection in an immunocompetent patient. | abstract: background: bartonella henselae (b. henselae) is considered a rare cause of granulomatous hepatitis. due to the fastidious growth characteristics of the bacteria, the limited sensitivity of histopathological stains, and the non-specific histological findings on liver biopsy, the diagnosis of hepatic bartonellosis can be difficult to establish. furthermore, the optimal treatment of established hepatic bartonellosis remains controversial. case presentation: we present a case of hepatic ... | 2012 | 22269175 |
| hemin binding protein c is found in outer membrane vesicles and protects bartonella henselae against toxic concentrations of hemin. | bartonella species are gram-negative, emerging bacterial pathogens found in two distinct environments. in the gut of the obligately hematophagous arthropod vector, bartonellae are exposed to concentrations of heme that are toxic to other bacteria. in the bloodstream of the mammalian host, access to heme and iron are severely restricted. bartonellae have unusually high requirements for heme, which is their only utilizable source of iron. although heme is essential for bartonella survival, little ... | 2012 | 22232189 |
| a new rickettsia species found in fleas collected from human dwellings and from domestic cats and dogs in senegal. | abstract the insects of the order siphonaptera, commonly named fleas, are vectors of pathogens around the world. our previous studies showed that 4.4% of acute febrile diseases in the sine-saloum region of senegal were due to rickettsia felis. the aim of this study was to explain the high prevalence of r. felis infections in two rural senegalese populations by an entomological, systematic monitoring protocol. a total of 232 fleas from three species (ctenocephalides felis, echidnophaga gallinac ... | 2012 | 22214272 |
| intruders below the radar: molecular pathogenesis of bartonella spp. | summary: bartonella spp. are facultative intracellular pathogens that employ a unique stealth infection strategy comprising immune evasion and modulation, intimate interaction with nucleated cells, and intraerythrocytic persistence. infections with bartonella are ubiquitous among mammals, and many species can infect humans either as their natural host or incidentally as zoonotic pathogens. upon inoculation into a naive host, the bartonellae first colonize a primary niche that is widely accepted ... | 2012 | 22232371 |
| identification of a new nanornase in bartonella. | in escherichia coli, only one essential oligoribonuclease (orn) can degrade oligoribonucleotides of five residues and shorter in length (nanorna). in bacillus subtilis, nrna and nrnb, which do not have any sequence similarity with orn, have been identified as functional analogs of orn. sequence comparisons did not allow identifying orn, nrna, or nrnb homologues in the genomes of the chlamydia/cyanobacteria and alphaproteobacteria family members. screening a genomic library from bartonella birtle ... | 2012 | 22262096 |
| bartonella quintana transmission from mite to family with high socioeconomic status. | to the editor: urban trench fever caused by bartonella quintana has been reported in persons who abuse alcohol and in homeless persons in large cities worldwide. symptoms vary from asymptomatic intermittent bacteremia to serious complications (1). pediculus humanus lice, the known vector of the infection, are not always identified, which raises the possibility that other vectors might also be involved (2). we report on an outbreak of b. quintana infection among a young family of high socioeconom ... | 2012 | 22257438 |
| molecular detection of bartonella species in ticks from peru. | a total of 103 ticks, collected from canines, horses, donkeys, and snakes from peru, were screened for the presence of bartonella dna by polymerase chain reaction analysis. bartonella dna was detected in two ticks using bartonella 16s-23s intergenic spacer region primers and in an additional two ticks using bartonella nadh dehydrogenase gamma subunit gene (nuog) primers. bartonella rochalimae eremeeva et al., b. quintana schmincke, and b. elizabethae daly et al. dna was detected in a rhipicephal ... | 2011 | 22238888 |
| q fever endocarditis in romania: the first cases confirmed by direct sequencing. | infective endocarditis (ie) is a serious, life-threatening disease with highly variable clinical signs, making its diagnostic a real challenge. a diagnosis is readily made if blood cultures are positive, but in 2.5 to 31% of all infective endocarditis cases, routine blood cultures are negative. in such situations, alternative diagnostic approaches are necessary. coxiella burnetii and bartonella spp. are the etiological agents of blood culture-negative endocarditis (bcne) most frequently identifi ... | 2011 | 22272146 |
| proteomic and bioinformatic analysis of outer membrane proteins of the protobacterium bartonella henselae (bartonellaceae). | bartonella henselae, an infectious agent causing cat-scratch disease and vasculoproliferative disorders in humans, is a fastidious facultative intracellular pathogen. the outer membrane proteins of b. henselae are key molecules that play a primary role in host-cell interactions. we isolated b. henselae outer membrane proteins, using the ionic detergent n-lauroyl sarcosine sodium salt and sodium carbonate, purification by two-dimensional (2-d) gel electrophoresis, and protein identification ... | 2011 | 21948745 |
| Cat Scratch Neuroretinitis: The Role of Acute and Convalescent Titers for Diagnosis. | ABSTRACT: Cat scratch neuroretinitis (CSN) is a clinical diagnosis supported by serological testing. We present 2 cases of CSN in which initial acute titers were negative or equivocal for Bartonella henselae while convalescent titers were shown to be positive. We report these cases to emphasize that a single acute negative titer is insufficient to exclude the diagnosis of CSN and that convalescent titers should be obtained in patients for whom there is a high clinical suspicion of the disease. | 2011 | 21941214 |
| Detection and Identification of Species-Specific Bacteria Associated with Synanthropic Mites. | Internal bacterial communities of synanthropic mites Acarus siro, Dermatophagoides farinae, Lepidoglyphus destructor, and Tyrophagus putrescentiae (Acari: Astigmata) were analyzed by culturing and culture-independent approaches from specimens obtained from laboratory colonies. Homogenates of surface-sterilized mites were used for cultivation on non-selective agar and DNA extraction. Isolated bacteria were identified by sequencing of the 16S rRNA gene. PCR amplified 16S rRNA genes were analyzed b ... | 2011 | 22057398 |
| vector-borne diseases in client-owned and stray cats from madrid, spain. | abstract the role of various vector-borne pathogens as a cause of disease in cats has not been clearly determined. the current study evaluated risk factors, clinical and laboratory abnormalities associated with ehrlichia spp., anaplasma spp., neorickettsia spp., leishmania spp., and bartonella spp. infection or exposure in 680 client-owned and stray cats from madrid, spain. our results indicate that a large portion (35.1%) of the cat population of madrid, spain, is exposed to at least one of t ... | 2011 | 22022820 |
| bartonella clarridgeiae, b. henselae and rickettsia felis in fleas from morocco. | a total of 554 fleas were collected in the moroccan casablanca and tiznit regions from domesticated animals and ruminants between august 2007 and october 2008 and were tested for the presence of rickettsia spp. and bartonella spp. using molecular methods. for the first time in morocco, we found rickettsia felis, the agent of flea-borne spotted fever in ctenocephalides felis; b. henselae, an agent of cat scratch disease; and bartonella clarridgeiae, a cat pathogen and potentially a human pathoge ... | 2011 | 22185943 |
| emerging incidence of lyme borreliosis, babesiosis, bartonellosis, and granulocytic ehrlichiosis in australia. | borrelia burgdorferi, the causative agent of lyme disease (ld), and babesia, bartonella, and ehrlichia species (spp.) are recognized tick-borne pathogens in humans worldwide. using serology and molecular testing, the incidence of these pathogens was investigated in symptomatic patients from australia. | 2011 | 22267937 |
| comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens. | glutaredoxin proteins (glxrs) are essential components of the glutathione system that reductively detoxify substances such as arsenic and peroxides and are important in the synthesis of dna via ribonucleotide reductases. nmr solution structures of glutaredoxin domains from two gram-negative opportunistic pathogens, brucella melitensis and bartonella henselae, are presented. these domains lack the n-terminal helix that is frequently present in eukaryotic glxrs. the conserved active-site cysteines ... | 2011 | 21904064 |
| rickettsia felis and bartonella spp. in fleas from cats in albania. | abstract fleas can serve as vectors for bacterial pathogens like bartonella and rickettsia species, which have been isolated worldwide. however, the knowledge of the epidemiology of vector-borne diseases in general and thus on flea-borne diseases in albania is limited. therefore, from 78 free-roaming cats in tirana, albania, fleas (371 ctenocephalides felis and 5 ctenocephalides canis) were collected to examine them for the presence of rickettsia and bartonella species. ten of the 371 c. felis ... | 2011 | 21995262 |
| comparison of the 'ca. liberibacter asiaticus' genome adapted for an intracellular lifestyle with other members of the rhizobiales. | an intracellular plant pathogen 'candidatus liberibacter asiaticus,' a member of the rhizobiales, is related to sinorhizobium meliloti, bradyrhizobium japonicum, nitrogen fixing endosymbionts, agrobacterium tumefaciens, a plant pathogen, and bartonella henselae, an intracellular mammalian pathogen. whole chromosome comparisons identified at least 50 clusters of conserved orthologous genes found on the chromosomes of all five metabolically diverse species. the intracellular pathogens 'ca. liberib ... | 2011 | 21876745 |
| presence of bartonella species in wild carnivores of northern spain. | the genus bartonella was detected by pcr in 5.7% (12/212) of wild carnivores from northern spain. based on hybridization and sequence analyses, bartonella henselae was identified in a wildcat (felis silvestris), bartonella rochalimae in a red fox (vulpes vulpes) and in a wolf (canis lupus), and bartonella sp. in badgers (meles meles). | 2011 | 22138983 |
| structure of a nudix hydrolase (mutt) in the mg(2+)-bound state from bartonella henselae, the bacterium responsible for cat scratch fever. | cat scratch fever (also known as cat scratch disease and bartonellosis) is an infectious disease caused by the proteobacterium bartonella henselae following a cat scratch. although the infection usually resolves spontaneously without treatment in healthy adults, bartonellosis may lead to severe complications in young children and immunocompromised patients, and there is new evidence suggesting that b. henselae may be associated with a broader range of clinical symptoms then previously believed. ... | 2011 | 21904053 |
| bid-f1 and bid-f2 domains of bartonella henselae effector protein bepf trigger together with bepc the formation of invasome structures. | the gram-negative, zoonotic pathogen bartonella henselae (bhe) translocates seven distinct bartonella effector proteins (beps) via the virb/vird4 type iv secretion system (t4ss) into human cells, thereby interfering with host cell signaling [1], [2]. in particular, the effector protein bepg alone or the combination of effector proteins bepc and bepf trigger massive f-actin rearrangements that lead to the establishment of invasome structures eventually resulting in the internalization of entire b ... | 2011 | 22043280 |
| Altitude-dependent Bartonella quintana Genotype C in Head Lice, Ethiopia. | To determine the presence of Bartonella quintana in head and body lice from persons in different locations in Ethiopia, we used molecular methods. B. quintana was found in 19 (7%) genotype C head lice and in 76 (18%) genotype A body lice. B. quintana in head lice was positively linked to altitude (p = 0.014). | 2011 | 22172306 |
| Molecular Study of Free-ranging Mule Deer and White-tailed Deer from British Columbia, Canada, for Evidence of Anaplasma spp. and Ehrlichia spp. | Twenty-three free-ranging white-tailed deer (WTD; Odocoileus virginianus) and six mule deer (MD; Odocoileus hemionus) from south-central British Columbia, Canada, were tested for Anaplasma marginale by msp5 gene-specific PCR and Ehrlichia spp. by 16S rRNA or citrate synthase (gltA) gene-specific PCR, as well as by PCR with universal 16S rRNA primers detecting a wide range of bacteria. No deer tested positive for A. marginale. Amplification with universal 16S rRNA primers followed by sequencing o ... | 2011 | 21933360 |
| identification of bartonella henselae in a horse from germany. | 2011 | 21388754 | |
| bartonella quintana infections in captive monkeys, china. | bartonella quintana has been considered to be specifically adapted to humans. our isolation of the organism from 2 of 36 captive rhesus macaques in china and finding antibodies against b. quintana in 12 of 33 indicates that the reservoir hosts of b. quintana may include primates other than humans. | 2011 | 21888799 |
| analysis of the bada stalk from bartonella henselae reveals domain-specific and domain-overlapping functions in the host cell infection process. | human pathogenic bartonella henselae cause cat scratch disease and vasculoproliferative disorders. an important pathogenicity factor of b. henselae is the trimeric autotransporter adhesin bartonella adhesin a (bada) which is modularly constructed and consists of a head, a long and repetitive neck-stalk module with 22 repetitive neck/stalk repeats and a membrane anchor. the bada head is crucial for bacterial adherence to host cells, binding to several extracellular matrix proteins and for the ind ... | 2011 | 21981119 |
| bacteriological and molecular identification of bartonella species in cats from different regions of china. | with the improvements in diagnostic techniques, bartonella henselae (b. henselae) infection has recently been recognized to cause a widening spectrum of diseases. cats are the natural reservoir hosts of b. henselae. the current study aims to investigate the prevalence of b. henselae infection in the cat populations in china. polymerase chain reaction (pcr) and bacterial cultures confirm that 12.7% of the tested cats were positive for the infection. old age and outdoor exposure were statistically ... | 2011 | 21909443 |
| bartonellae of the namaqua rock mouse, micaelamys namaquensis (rodentia: muridae) from south africa. | the aim of this study was to determine bartonella prevalence and diversity in namaqua rock mice, micaelamys namaquensis, a species endemic to south africa, which can attain pest status. a total of 100 heart samples collected monthly from march to december were screened for bartonella genome presence using three primer sets targeting the citrate synthase (glta) gene, the nadh dehydrogenase gamma subunit (nuog) gene and the rna polymerase β-subunit-encoding gene (rpob). an overall prevalence of 44 ... | 2011 | 22204791 |
| bartonella henselae engages inside-out and outside-in signaling by integrin β1 and talin1 during invasome-mediated bacterial uptake. | the virb/d4 type iv secretion system (t4ss) of the bacterial pathogen bartonella henselae (bhe) translocates seven effector proteins (bepa-bepg) into human cells that subvert host cellular functions. two redundant pathways dependent on bepg or the combination of bepc and bepf trigger the formation of a bacterial uptake structure termed the invasome. invasome formation is a multi-step process consisting of bacterial adherence, effector translocation, aggregation of bacteria on the cell surface an ... | 2011 | 22045736 |
| zoonotic bartonella species in fleas and blood from red foxes in australia. | abstract bartonella are arthropod-borne, fastidious, gram-negative, and aerobic bacilli distributed by fleas, lice, sand flies, and, possibly, ticks. the zoonotic bartonella species, bartonella henselae and bartonella clarridgeiae, which are the causes of cat scratch disease and endocarditis in humans, have been reported from cats, cat fleas, and humans in australia. however, to date, there has been no report of b. henselae or b. clarridgeiae in australian wild animals and their ectoparasites. ... | 2011 | 21919728 |
| bartonella clarridgeiae in fleas, tahiti, french polynesia. | 2011 | 21888825 | |
| experimental infection by capillary tube feeding of rhipicephalus sanguineus with bartonella vinsonii subspecies berkhoffii. | it has been speculated that ticks may serve as vectors of bartonella species. circumstantial, clinical, epidemiological and serological evidence suggest that b. vinsonii subspecies berkhoffii (b. v. berkhoffii) might be transmitted by rhipicephalus sanguineus. the purpose of the present study was to determine whether adult r. sanguineus ticks can be infected with a b. v. berkhoffii genotype ii isolate via capillary tube feeding and whether the infection can then be transmitted from adult females ... | 2011 | 22062313 |
| a multi-gene analysis of diversity of bartonella detected in fleas from algeria. | we report the molecular detection of several bartonella species in 44 (21.5%) of 204 fleas from algeria collected from 26 rodents and 7 hedgehogs. bartonella elizabethae and b. clarridgeiae were detected in the fleas collected on hedgehogs. bartonella tribocorum and b. elizabethae were detected in fleas collected from rats and mice, and sequences similar to an unnamed bartonella sp. detected in rodents from china were detected in rats as well as a genotype of bartonella closely related to barton ... | 2011 | 22153359 |
| bartonellae in animals and vectors in new caledonia. | bartonellae are gram-negative facultative intracellular alpha-proteobacteria from the family bartonellaceae. the natural history of bartonellae consists of a reservoir/host, which is a vertebrate with chronic intravascular infection with sustained bacteremia, and a vector (usually an arthropod) that transfers the bacteria from the reservoir to a susceptible yet uninfected host. in order to reveal the sources and reservoirs of bartonella infection in animals and vectors in new caledonia, we colle ... | 2011 | 22018646 |
| Suspected Bartonella-associated myocarditis and supraventricular tachycardia in a cat. | A 4-year old female spayed domestic short hair cat presented for evaluation of a tachyarrhythmia identified on routine physical examination. Supraventricular tachycardia (SVT) was identified on electrocardiogram (ECG). Echocardiogram failed to identify any structural heart disease. A positive Bartonella antibody titer was identified on serological evaluation. The cat received anti-arrhythmics for control of the SVT and azithromycin for Bartonella. After completion of antibiotic therapy, a four-f ... | 2011 | 22051527 |
| no evidence of bartonella quintana but detection of acinetobacter baumannii in head lice from elementary schoolchildren in paris. | the human body louse is the only known vector of bartonella quintana. however, the presence of this bacterium has recently been detected in the head lice of homeless individuals and nepalese slum children. previous studies have reported the isolation of acinetobacter baumannii from the body lice of homeless individuals. an epidemiological survey including 74 schools was conducted between 2008 and 2009 in paris. after a first visual examination, the hair of children with suspected pediculosis was ... | 2011 | 21974965 |
| bartonella spp. bacteremia in high-risk immunocompetent patients. | serum and blood samples from 192 patients, who reported animal exposure (100.0%) and recent animal bites or scratches (88.0%), were screened for antibodies by indirect immunofluorescence assays and for bacteremia using the bapgm (bartonella alpha proteobacteria growth medium) platform. predominant symptoms included fatigue (79.2%), sleeplessness (64.1%), joint pain (64.1%), and muscle pain (63.0%). bartonella spp. seroreactivity or bacteremia was documented in 49.5% (n = 95) and 23.9% (n = 46) o ... | 2011 | 21996096 |
| Transfer of R388 derivatives by a pathogenesis-associated type IV secretion system into both bacteria and human cells. | Bacterial type IV secretion systems (T4SSs) are involved in processes such as bacterial conjugation and protein translocation to animal cells. In this work, we have switched the substrates of T4SSs involved in pathogenicity for DNA transfer. Plasmids containing part of the conjugative machinery of plasmid R388 were transferred by the T4SS of human facultative intracellular pathogen Bartonella henselae to both recipient bacteria and human vascular endothelial cells. About 2% of the human cells ex ... | 2011 | 21908662 |
| high frequency of tropheryma whipplei in culture-negative endocarditis. | "classical" whipple's disease (cwd) is caused by tropheryma whipplei and is characterized by arthropathy, weight loss, and diarrhea. t. whipplei infectious endocarditis (twie) is rarely reported, either in the context of cwd or as isolated twie without signs of systemic infection. the frequency of twie is unknown, and systematic studies are lacking. here, we performed an observational cohort study on the incidence of t. whipplei infection in explanted heart valves in two german university center ... | 2011 | 22135251 |
| role of the spleen in bartonella spp. infection. | bartonella spp. are intra-erythrocytic pathogens of mammals. in this study, we investigated the role of the spleen, and other tissue and organs in bartonella infection. using an in vivo model of mice infection by bartonella birtlesii, we detected accumulation of bacteria in the spleen, with transient infection of the liver, but failed to detect any bacteria in brain or lymph nodes. we then compared bacteraemia in normal balb/c mice and in splenectomized mice. bacteraemia in splenectomized mice w ... | 2011 | 22098417 |
| onset of cutaneous vasculitis and exacerbation of iga nephropathy after bartonella henselae infection. | bartonella henselae is the aetiological agent of cat-scratch disease. recently, there have been reports of other conditions associated with this bacterium, including leucocytoclastic vasculitis, thrombocytopenic purpura, maculopapular and urticarial eruptions, granuloma annulare, erythema nodosum, erythema marginatum and erythema annulare. we report the first case, to our knowledge, of the simultaneous occurrence of cutaneous vasculitis and nephrotic syndrome in a 65-year-old woman with iga neph ... | 2011 | 21981612 |
| molecular detection and identification of bartonella species in xenopsylla cheopis fleas (siphonaptera: pulicidae) collected from rattus norvegicus rats in los angeles, california. | of 200 individual xenopsylla cheopis fleas removed from rattus norvegicus rats trapped in downtown los angeles, ca, 190 (95%) were positive for the presence of bartonella dna. ninety-one amplicons were sequenced: bartonella rochalimae-like dna was detected in 66 examined fleas, and bartonella tribocorum-like dna was identified in 25 fleas. the data obtained from this study demonstrate an extremely high prevalence of bartonella dna in rat-associated fleas. | 2011 | 21908631 |
| Bartonellosis in cats: a role in uveitis? | Bartonellosis has been widely studied in human and veterinary medicine over the past two decades. Despite this fact, it remains an enigmatic disease in many ways. The causative bacteria, Bartonella spp, are transmitted to cats by fleas and thus the prevalence in cat populations, particularly in temperate climates, is high. Most cats, whether infected naturally or experimentally, remain asymptomatic. Thus, correlating the presence of the organism to clinical disease, including uveitis, in cats ha ... | 2011 | 21923819 |
| molecular prevalence of bartonella, babesia, and hemotropic mycoplasma sp. in dogs with splenic disease. | among diseases that cause splenomegaly in dogs, lymphoid nodular hyperplasia (lnh), splenic hemangiosarcoma (hsa), and fibrohistiocytic nodules (fhn) are common diagnoses. the spleen plays an important role in the immunologic control or elimination of vector-transmitted, blood-borne pathogens, including bartonella sp., babesia sp., and hemotropic mycoplasma sp. | 2011 | 22092618 |
| Combining climatic projections and dispersal ability: a method for estimating the responses of sandfly vector species to climate change. | BACKGROUND: In the Old World, sandfly species of the genus Phlebotomus are known vectors of Leishmania, Bartonella and several viruses. Recent sandfly catches and autochthonous cases of leishmaniasis hint on spreading tendencies of the vectors towards Central Europe. However, studies addressing potential future distribution of sandflies in the light of a changing European climate are missing. METHODOLOGY: Here, we modelled bioclimatic envelopes using MaxEnt for five species with proven or assum ... | 2011 | 22140590 |
| Detection of Bartonella henselae IgM in serum of experimentally infected and naturally exposed cats. | Results of Bartonella henselae blood culture, polymerase chain reaction (PCR) assay on blood, or IgG antibody assays do not always correlate with the presence or absence of clinical disease in cats, and B. henselae IgG antibodies in serum do not always correlate with bacteremia. However, little is known concerning Bartonella spp. IgM antibodies in naturally exposed cats. | 2011 | 22092615 |
| introduction to the alpha-proteobacteria: wolbachia and bartonella, rickettsia, brucella, ehrlichia, and anaplasma. | wolbachia is an obligate intracellular endosymbiont and likely mutualist living within the heartworm dirofilaria immitis and a number of other filarial nematodes in the family onchocercidae. the bacterial infection is passed from worm to worm transovarially; the organisms are in ovarian cells, the developing microfilariae, and multiply and persist in all later developmental stages through the mosquito and into the next host. besides being present in the ovaries of the adult worms, they also are ... | 2011 | 22152604 |
| [Comparison of the indirect immunofluorescence assay performance of bartonella henselae antigens obtained by co-cultivation in vero and HeLa cells]. | The laboratory diagnosis of Bartonella henselae infection is mainly based on serological testing by indirect immunofluorescence assay (IFA). Cell line co-cultivation with B.henselae and agar derivated antigens are the two major procedures used for evaluation of anti-Bartonella antibodies. Vero and Hep-2 cell lines are the most commonly used media for co-cultivation both in-house and commercial diagnostic kits production. However, HeLa cells which are easily supplied and grown, also can easily be ... | 2011 | 21935779 |
| a serological investigation of bartonella henselae infection in cats in turkey. | bartonella henselae is the causative agent of cat scratch disease (csd) in humans. cats are the main reservoir of this bacterium and may infect humans through scratches and bites. the purpose of this study was to determine the b. henselae seroprevalence in cats in turkey. a total of 298 cats blood samples were collected from six different provinces of turkey. sera were tested for the presence of anti-b. henselae igg antibodies by indirect fluorescent antibody test (ifa). the seroprevalence of b. ... | 2011 | 21737965 |
| molecular detection of rickettsia felis, bartonella henselae, and b. clarridgeiae in fleas from domestic dogs and cats in malaysia. | the presence of rickettsia felis, bartonella henselae and b. clarridgeiae in 209 fleas (ctenocephalides felis) obtained from domestic cats and dogs in several locations in malaysia was investigated in this study. using a polymerase chain reaction specific for the citrate synthase (glta) and 17-kd antigenic protein (17kd) genes of rickettsiae, we detected r. felis dna in 6 (2.9%) fleas. for detection of bartonellae, amplification of the heme-binding protein (pap31) and riboflavin synthase (ribc) ... | 2011 | 22049052 |
| Surveillance using serological and molecular methods for the detection of infectious agents in captive Brazilian neotropic and exotic felids. | The aim of the current study was to investigate the exposure of captive wild felids to various infectious pathogens using serological and molecular methods. One hundred and fifty-nine neotropic felids and 51 exotic felids from 28 captive settings in Brazil were tested. While antibodies against Feline parvovirus and Feline coronavirus (FCoV), Feline calicivirus and Bartonella spp. were frequently detected by serologic tests, antibodies against Felid herpesvirus 1 or infection with hemotropic myco ... | 2011 | 21908268 |
| diversity of bartonella species detected in arthropod vectors from animals in australia. | a variety of bartonella species were detected in two species of ticks and three species of fleas collected from marsupial hosts; brush-tailed bettong or woylie (bettongia penicillata) and western barred bandicoots (perameles bougainville) and from a rodent host; rattus fuscipes in western australia. bartonella species were detected using nested-pcr of the glta gene and the 16s-23s ribosomal internal transcribed spacer region (its), and species were characterized using dna sequencing of the 16s r ... | 2011 | 21862131 |
| fluorescence in-situ hybridization for the identification of bacterial species in archival heart valve sections of canine bacterial endocarditis. | bacterial endocarditis (be) is defined as inflammation of cardiac valve structures and/or the endocardium secondary to bacterial infection. canine valvular be is associated with significant morbidity and mortality and ante-mortem diagnosis and post-mortem identification of causative organisms is problematic. identification of bacteria in canine be has traditionally relied on visualization of organisms on histological sections stained with haematoxylin and eosin (he), gram and modified steiner's ... | 2011 | 22030263 |
| gammopathy in a spanish dog infected with bartonella henselae. | generalised pyogranulomatous disease and hyperviscosity syndrome associated with a presumed monoclonal gammopathy was diagnosed in a three-year-old intact female pomeranian. the bartonella henselae antibody titer was 1:64 and bartonella species dna was amplified from the splenic tissue. monoclonal gammopathies in dogs are typically associated with plasma cell and lymphoid dyscrasias and other inflammatory or infectious diseases such as ehrlichiosis and leishmaniosis. based on this case report, i ... | 2011 | 21906064 |
| Bartonella quintana in Ethiopian lice. | Head and clothing lice from Jimma, Ethiopia were investigated for pathogenic bacteria. Genomic DNA from pools of lice was subjected to PCR analysis for Bartonella spp., Borrelia spp. Coxiella burnetii, Rickettsia spp. and Yersinia pestis. All 102 lice pools were negative for the afore mentioned pathogens, with the exception of Bartonella species found among 6 of 65 (9.2%) head lice pools and1 of 33 clothing lice pools. Identification was achieved by sequencing the ribosomal intragenic transcribe ... | 2011 | 22019400 |
| bartonella infective endocarditis of a prosthetic aortic valve with a subvalvular abscess. | a patient with a prosthetic aortic valve, and culture negative endocarditis caused by bartonella henselae presented with nonspecific constitutional symptoms, skin rash, and then later developed acute renal failure. the patient underwent redo sternotomy, aortic root, and ascending aorta replacement with a homograft, which resolved his symptoms and the renal failure. | 2011 | 21848606 |
| serological response to bartonella species in febrile patients from nepal. | the bartonella-associated illnesses are spread world-wide and involve a broad spectrum of signs and symptoms in humans. several bartonella species have been shown to be responsible for cases of febrile illnesses. little information exists on distribution of bartonella species and their role in human diseases in nepal. our preliminary study, a retrospective serological survey of archived specimens, suggests that bartonella antibodies are prevalent among febrile patients in the kathmandu valley of ... | 2011 | 21955739 |
| structure of fructose bisphosphate aldolase from bartonella henselae bound to fructose 1,6-bisphosphate. | fructose bisphosphate aldolase (fbpa) enzymes have been found in a broad range of eukaryotic and prokaryotic organisms. fbpa catalyses the cleavage of fructose 1,6-bisphosphate into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. the ssgcid has reported several fbpa structures from pathogenic sources, including the bacterium brucella melitensis and the protozoan babesia bovis. bioinformatic analysis of the bartonella henselae genome revealed an fbpa homolog. the b. henselae fbpa enzym ... | 2011 | 21904049 |
| invasion of canine erythrocytes by bartonella vinsonii subsp. berkhoffii. | bartonella vinsonii subsp. berkhoffii is a recognized cause of endocarditis in dogs and human patients and has been associated with cardiac arrhythmias, myocarditis, granulomatous lymphadenitis, polyarthritis, and granulomatous rhinitis in dogs. little is known regarding the mode of transmission or cellular localization of this bacteria following infection of a canine host. the aim of the current study was to determine whether erythrocytes may serve as a site of infection by b. vinsonii subsp. b ... | 2011 | 22071179 |
| bartonella and rickettsia in arthropods from the lao pdr and from borneo, malaysia. | rickettsioses and bartonelloses are arthropod-borne diseases of mammals with widespread geographical distributions. yet their occurrence in specific regions, their association with different vectors and hosts and the infection rate of arthropod-vectors with these agents remain poorly studied in south-east asia. we conducted entomological field surveys in the lao pdr (laos) and borneo, malaysia by surveying fleas, ticks, and lice from domestic dogs and collected additional samples from domestic c ... | 2011 | 22153360 |
| Experimental infection of Swiss webster mice with four rat bartonella strains: host specificity, bacteremia kinetics, dose dependent response, and histopathology. | Groups of Swiss Webster outbred mice were each inoculated with one of four bartonella strains originally isolated from Rattus spp. at doses ranging from 10(1) to 10(7) bacteria per mouse. One strain, Rn1691yn (Bartonella coopersplainensis-like), infected mice and produced bacteremias at levels up to 10(5)bacteria/ml of blood and from 3 to 8 weeks duration. A dose dependent response was also observed with differing proportions of mice bacteremic following inoculation at different doses. In additi ... | 2011 | 21908045 |
| Clinicopathologic correlation of epidemiologic and histopathologic features of pediatric bacterial lymphadenitis. | Infection is a common cause of lymphadenopathy in children and has numerous microbial etiologies. Lymph node biopsy is considered a keystone in arriving at a definite diagnosis. An accurate differential diagnosis from a lymph node biopsy can expedite diagnosis and minimize ancillary testing. | 2011 | 22032579 |
| identification of novel bartonella spp. in bats and evidence of asian gray shrew as a new potential reservoir of bartonella. | many studies indicated that small mammals are important reservoirs for bartonella species. using molecular methods, several studies have documented that bats could harbor bartonella. this study was conducted to investigate the relationship of bartonella spp. identified in bats and small mammals living in the same ecological environment. during may 2009 and march 2010, a total of 102 blood specimens were collected. by whole blood culture and molecular identification, a total of 6 bats, 1 rodent a ... | 2011 | 22005177 |
| Rickettsiae in arthropods collected from red foxes (Vulpes vulpes) in France. | The aim of our study was to detect the presence of Rickettsia spp. and Bartonella spp. in ticks and fleas collected from red foxes (Vulpes vulpes) in southeastern France during 2008. Using a genus-specific quantitative PCR (qPCR) assay, which was followed by a species-specific qPCR assay for the positive samples, 45.2% (33/73) of ticks (Rhipicephalus turanicus) were found to be infected with Rickettsia massiliae. 10.5% (2/19) of the fleas (Archaeopsylla erinacei) collected in the study tested po ... | 2011 | 22118782 |
| bartonella species bacteremia in two patients with epithelioid hemangioendothelioma. | bartonella henselae and b. koehlerae bacteremia was documented in two epithelioid hemangioendothelioma patients and b. koehlerae bacteremia in an asymptomatic partner of one of the patients. considering the biology and clinically variable natural history of epithelioid hemangioendothelioma, these results suggest that chronic bartonella infection could have a role in the development of this vascular neoplasm. bartonella spp. are known to induce vasoproliferative tumors in immunocompromised patien ... | 2011 | 21918021 |
| Genetic characterization of flea-derived Bartonella species from native animals in Australia suggests host-parasite co-evolution. | Fleas are important arthropod vectors for a variety of diseases in veterinary and human medicine, and bacteria belonging to the genus Bartonella are among the organisms most commonly transmitted by these ectoparasites. Recently, a number of novel Bartonella species and novel species candidates have been reported in marsupial fleas in Australia. In the present study the genetic diversity of marsupial fleas was investigated; 10 species of fleas were collected from seven different marsupial and pla ... | 2011 | 21856444 |
| Inhibition of fibroblast apoptosis by Borrelia afzelii, Coxiella burnetii and Bartonella henselae. | Apoptosis is a genetically controlled mechanism of cell death involved in the regulation of tissue homeostasis. The aim of this study was to investigate the influence of Borrelia afzelii, Coxiella burnetii, and Bartonella henselae bacteria on apoptosis measured as the level of caspase 3 activity in human fibroblast cells HEL-299. Our findings show that C. burnetii bacteria may inhibit the process of apoptosis in the host cells for a long time. This can permit intracellular survival in the host a ... | 2011 | 22184936 |
| Evaluation of clinical specimens for Rickettsia, Bartonella, Borrelia, Coxiella, Anaplasma, Franciscella and Diplorickettsia positivity using serological and molecular biology methods. | We monitored clinical samples from patients of different age groups from selected regions in Slovakia. Overall seroprevalence evaluated by immunofluorescence (IFA) using nine Bartonella, two Borrelia, six rickettsial (spotted fever and typhus group), two Coxiella, and one human granulocytic ehrlichiosis Anaplasma, Franciscella tularensis and Diplorickettsia massiliensis antigens, in rural and city populations of Slovak Republic, was found to be 32% positive for spotted fever group rickettsiae. O ... | 2011 | 22098390 |
| challenges in the clinical management of blood-culture negative endocarditis: case of bartonella henselae infection. | 2011 | 21396492 | |
| three cases of pr3-anca positive subacute endocarditis caused by attenuated bacteria (propionibacterium, gemella, and bartonella) complicated with kidney injury. | subacute bacterial endocarditis (sbe) associated with antiproteinase-3 antineutrophil cytoplasmic antibodies (pr3-anca) has previously been reported in 10 cases of streptococcus viridans and in 1 case of escherichia faecalis infection. most of these patients had hypocomplementemia and were positive for several autoantibodies. the infections in most of these patients showed good responses to antibiotic treatment. we report three patients with anca-positive sbe, which was induced by attenuated slo ... | 2011 | 21400245 |
| bartonella henselae endocarditis of percutaneously implanted pulmonary valve: a case report. | percutaneous pulmonary valve implantation (ppvi) has revolutionized the management of right ventricular outflow tract dysfunction after repaired congenital heart disease. the technology is considered to be safe, with a relatively low complication rate. infection is one of the described complications of ppvi, and to date five cases of culture-positive infective endocarditis of percutaneously implanted pulmonary valve have been reported worldwide. herein is reported the first ever case of culture- ... | 2011 | 21404904 |
| 18f-fluoro-2-deoxyglucose positron emission tomography-negative endocarditis lenta caused by bartonella henselae. | it has been suggested that 18f-fluorodeoxyglucose positron emission tomography (fdg-pet) might serve as a tool for the often difficult diagnosis of infective endocarditis. the case is described of a patient with a bartonella henselae endocarditis with a negative fdg-pet. this case report demonstrates that negative fdg-pet findings do not rule out the presence of endocarditis. | 2011 | 21404906 |
| eschar and neck lymphadenopathy caused by francisella tularensis after a tick bite: a case report. | 2011 | 21418587 | |
| high throughput, multiplexed pathogen detection authenticates plague waves in medieval venice, italy. | historical records suggest that multiple burial sites from the 14th-16th centuries in venice, italy, were used during the black death and subsequent plague epidemics. | 2011 | 21423736 |
| [louse-borne infections in humans]. | 2011 | 21450425 | |
| [sero-epidemiological investigation on rickettsia typhi, bartonella henselae and orientia tsutsugamushi in farmers from rural areas of tianjin, 2007 - 2009.] | objective: to study the sero-epidemiological status regarding rickettsia (r.) typhi, bartonella (b.) henselae and orientia (o.) tsutsugamushi in farmers from rural areas of tianjin. methods: field epidemiological surveys were performed in 8 districts (county) of tianjin city from 2007 to 2009. 886 farmers were randomly recruited and their serum samples collected to detect the specific antibodies of r. typhi, b. henselae and o. tsutsugamushi by micro-indirect immunoflorescence (ifa). results: the ... | 2011 | 21457660 |
| seasonality of cat-scratch disease, france, 1999-2009. | cat-scratch disease is seasonal in the united states and japan; but no data are available from europe. to assess the seasonality of the disease in france, we analyzed lymph node biopsy specimens collected during 1999-2009. most (87.5%) cases occurred during september-april and peaked in december. | 2011 | 21470466 |
| multilocus sequence typing of bartonella henselae in the united kingdom indicates that only a few, uncommon sequence types are associated with zoonotic disease. | bartonella henselae is one of the most common zoonotic agents acquired from companion animals (cats) in industrialized countries. nonetheless, although the prevalence of infections in cats is high, the number of human cases reported is relatively low. one hypothesis for this discrepancy is that b. henselae strains vary in their zoonotic potential. to test this hypothesis, we employed structured sampling to explore the population structure of b. henselae in the united kingdom and to determine the ... | 2011 | 21471345 |
| bartonella quintana in head louse nits. | the body louse is the principal vector of bartonella quintana, the causative organism of trench fever, but b. quintana dna has also been detected in adult head lice. because there are no characteristics that distinguish the body louse from the head louse, we decided to test head louse nits collected from a homeless man for the presence of b. quintana dna. all of the sampled nits tested positive by real-time pcr, and intergenic spacer region (its) gene sequences shared 100% similarity to the corr ... | 2011 | 21477003 |
| prevalence of rickettsia felis and the first identification of bartonella henselae fizz/cal-1 in cat fleas (siphonaptera: pulicidae) from taiwan. | cat fleas (ctenocephalides felis [bouché]) are the primary ectoparasites of dog and cat populations. in this study, we report the monthly population dynamics of rickettsia felis and bartonella spp. (two zoonotic pathogens that can cause human disease) in cat fleas collected from dogs and cats in taipei, taiwan, from december 2006 to december 2007. natural r. felis infection in individual cat fleas was assessed by polymerase chain reaction (pcr) using prf-, ompb-, and glta-specific primer pairs. ... | 2011 | 21485388 |
| infective endocarditis. | infective endocarditis (ie) is lethal if not aggressively treated with antibiotics alone or in combination with surgery. the epidemiology of this condition has substantially changed over the past four decades, especially in industrialized countries. once a disease that predominantly affected young adults with previously well-identified valve disease-mostly chronic rheumatic heart disease-ie now tends to affect older patients and new at-risk groups, including intravenous-drug users, patients with ... | 2011 | 21487430 |
| adhesion and host cell modulation: critical pathogenicity determinants of bartonella henselae. | abstract: bartonella henselae, the agent of cat scratch disease and the vasculoproliferative disorders bacillary angiomatosis and peliosis hepatis, contains to date two groups of described pathogenicity factors: adhesins and type iv secretion systems. bartonella adhesin a (bada), the trw system and possibly filamentous hemagglutinin act as promiscous or specific adhesins, whereas the virulence locus (vir)b/vird4 type iv secretion system modulates a variety of host cell functions. bada mediates b ... | 2011 | 21489243 |
| identification of bartonella henselae in 2 cats with pyogranulomatous myocarditis and diaphragmatic myositis. | most cats infected with bartonella henselae remain outwardly healthy carriers for years; however, self-limiting fever, transient anemia, neurologic dysfunction, lymphadenopathy, reproductive disorders, aortic valvular endocarditis, and neutrophilic myocarditis have been described in experimentally or naturally infected cats. two cats in a north carolina shelter died with pyogranulomatous myocarditis and diaphragmatic myositis. bacteria were visualized in the lesions by warthin-starry silver impr ... | 2011 | 21490304 |
| in silico analysis of 16s ribosomal rna gene sequencing based methods for identification of medically important aerobic gram-negative bacteria. | the study is the first one that provides guidelines on the usefulness of full and 527-bp 16s rrna gene sequencing and microseq databases for identifying medically important aerobic gram-negative bacteria. overall, full and 527-bp 16s rrna gene sequencing can identify 26.1% and 32.6% of medically important aerobic gram-negative bacteria confidently to the species level, whereas the full-microseq and 500-microseq databases can identify 15.2% and 26.1% of medically important aerobic gram-negative b ... | 2011 | 21498652 |
| absence of zoonotic bartonella species in questing ticks: first detection of bartonella clarridgeiae and rickettsia felis in cat fleas in the netherlands. | abstract: | 2011 | 21501464 |
| seroprevalence of toxoplasma gondii and concurrent bartonella spp., feline immunodeficiency virus, feline leukemia virus, and dirofilaria immitis infections in egyptian cats. | abstract toxoplasma gondii and bartonella spp. are zoonotic pathogens of cats. feline immunodeficiency virus (fiv) and feline leukemia virus (felv) are related to human immunodeficiency virus and human leukemia virus, respectively, and these viruses are immunosuppressive. in the present study, the prevalence of antibodies to t. gondii , bartonella spp., fiv, as well as felv and dirofilaria immitis antigens was determined in sera from feral cats ( felis catus ) from cairo, egypt. using a modified ... | 2011 | 21506874 |
| bone pain and fever in an adolescent and his sibling. cat scratch disease (csd). | 2011 | 21513084 | |
| bartonella spp. in feral pigs, southeastern united states. | in conjunction with efforts to assess pathogen exposure in feral pigs from the southeastern united states, we amplified bartonella henselae, b. koehlerae, and b. vinsonii subsp. berkhoffii from blood samples. feral pigs may represent a zoonotic risk for hunters or butchers and pose a potential threat to domesticated livestock. | 2011 | 21529405 |
| trimeric autotransporter adhesin-dependent adherence of bartonella henselae, bartonella quintana and yersinia enterocolitica to matrix components and endothelial cells under static and dynamic flow conditions. | trimeric autotransporter adhesins (taas) are important virulence factors of gram-negative bacteria responsible for adherence to extracellular matrix (ecm) and host cells. here, we analyzed three different taas [bartonella adhesin a (bada) of bartonella henselae, variably expressed outer membrane proteins (vomps) of bartonella quintana, yersinia adhesin a (yada) of yersinia enterocolitica] for mediating bacterial adherence to ecm and endothelial cells. using static (cell culture vials) and dynami ... | 2011 | 21536788 |
| bartonella spp. dna in cardiac tissues from dogs in colorado and wyoming. | background: several bartonella species (spp.) have been identified in dogs diagnosed with infectious endocarditis (ie) or myocarditis. objective: to interrogate cardiac tissues of dogs with suspected ie for the presence of bartonella spp. dna of dogs in the rocky mountain states. animals: nine dogs with a clinical diagnosis of endocarditis from january 1990 to june 2008 were included. methods: in this retrospective study, medical records at the veterinary teaching hospital were searched. animals ... | 2011 | 21539606 |
| brief communication: co-detection of bartonella quintana and yersinia pestis in an 11th-15th burial site in bondy, france. | historical and anthropological data suggest that skeletons excavated from an 11th to 15th century mass grave in bondy, france, may be those of victims of the great plague. using high-throughput real-time pcr investigation of the dental pulp collected from 14 teeth from five such skeletons, we detected bartonella quintana dna in three individuals and yersinia pestis dna in two individuals. dna from five other deadly pathogens was not found. suicide pcr genotyping confirmed y. pestis dna belonging ... | 2011 | 21541920 |
| adhesins of bartonella spp. | adhesion to host cells represents the first step in the infection process and one of the decisive features in the pathogenicity of bartonella spp. b. henselae and b. quintana are considered to be the most important human pathogenic species, responsible for cat scratch disease, bacillary angiomatosis, trench fever and other diseases. the ability to cause vasculoproliferative disorders and intraerythrocytic bacteraemia are unique features of the genus bartonella. consequently, the interaction with ... | 2011 | 21557057 |
| bartonella quintana endocarditis of the tricuspid and mitral valves. | bartonella quintana is a gram-negative microorganism that can lead to culture-negative infective endocarditis (ie) in immunocompromised patients. here, we present an exceptionally rare case of a 70-year-old male with bartonella quintana-associated ie primarily limited to the tricuspid valve that spread to the mitral valve after tricuspid valve replacement. this was then complicated by infective spondylodiscitis of the thoracic vertebrae, ultimately resulting in death due to cardiac arrest. | 2011 | 21557164 |
| prosthetic valve endocarditis caused by bartonella quintana in a patient during immunosuppressive therapies for collagen vascular diseases. | bartonella quintana, known to cause various clinical symptoms, is increasingly recognized as one important cause of culture-negative endocarditis. we report a case of infectious endocarditis with b. quintana on the prosthetic valve, accompanied by proteinase 3-antineutrophil cytoplasmic antibody-positive collagen vascular disease-like symptoms 1 year earlier. | 2011 | 21558050 |
| prevalence of bartonella species, haemoplasmas and toxoplasma gondii in cats in scotland. | the objective of this study was to determine the prevalence rates for select infectious agents of cats presented to the royal (dick) school of veterinary studies at the university of edinburgh, scotland. whole blood, serum, and oral mucosal and nail bed swabs were collected. while ehrlichia species, anaplasma species or rickettsia felis dna were not amplified from any cat, 44.2% of the cats had evidence of infection or exposure to either a bartonella species (15.3% were seropositive and 5.8% pol ... | 2011 | 21570883 |