Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| detection of new delhi metallo-beta-lactamase-1 (ndm-1) in carbapenem- resistant klebsiella pneumoniae isolated from a university hospital in iran. | new delhi metallo-beta-lactamase-1(ndm-1) is a novel type of metallo-beta-lactamase (mbl) which inactivates all β-lactam antibiotics except aztreonam. enterobacteriaceae expressing ndm-1 have been identified worldwide. the aim of this study was to detect mbls in carbapenem-resistant k. pneumoniae isolates obtained from patients hospitalized in one of the university hospitals in isfahan, iran. | 2017 | 27418777 |
| impacts of hypervirulence determinants on clinical features and outcomes of bacteremia caused by extended-spectrum β-lactamase-producing klebsiella pneumoniae. | we investigated the implications of hypervirulence determinants on clinical features of 48 adult patients with bacteremia caused by extended-spectrum β-lactamase-producing klebsiella pneumoniae. isolates in the hypervirulence group included any of the following virulence determinants: k1/k2 capsule serotypes, hypermucoviscosity phenotype, rmpa gene, or rmpa2 gene. nonhypervirulence group isolates were negative for all of the above virulence factors. in this study, all isolates used were non-k1/k ... | 2017 | 27380450 |
| first report of extended-spectrum β-lactamases among clinical isolates of klebsiella pneumoniae in gaza strip, palestine. | sixteen broad-spectrum cephalosporin-resistant klebsiella pneumoniae isolates were recovered between april and june 2013 from palestinian hospitals, gaza strip. genes encoding extended-spectrum beta-lactamases (esbls) and other resistance genes were characterized by polymerase chain reaction and sequencing. the following β-lactamase genes were detected: blactx-m-15+ blashv1+ blatem-1 (six isolates), blactx-m-15+ blashv5+ blaoxa-1 (two isolates), blactx-m-14a (two isolates), blactx-m-15+ blashv33 ... | 2017 | 27294803 |
| tigecycline susceptibility and molecular resistance mechanisms among clinical klebsiella pneumoniae strains isolated during non-tigecycline treatment. | tigecycline is one of the few therapeutic options that are available for treating serious clinical infections. however, tigecycline nonsusceptible enterobacteriaceae has emerged recently in china. in this study, a total of 28 clinical klebsiella pneumoniae isolates that were not previously exposed to tigecycline were collected and confirmed for tigecycline minimum inhibitory concentrations (mics) using standard broth microdilution tests. to elucidate the mechanisms underlying molecular resistanc ... | 2017 | 27219271 |
| characterization of the genetic environment of the blakpc-2 gene among klebsiella pneumoniae isolates from a chinese hospital. | infection caused by carbapenem-resistant klebsiella pneumoniae has become a major healthcare threat and kpc-2 enzyme is a dominant factor mediating carbapenems resistance in k. pneumoniae. this study was designed to determine the genetic environment of blakpc-2, which prevailed in clinical k. pneumoniae isolates recovered in huashan hospital, shanghai, china. forty-two clinical isolates were included in this study by blakpc-2 screening. after multilocus sequence typing and plasmid analyses of pc ... | 2017 | 27183358 |
| meropenem for treating kpc-producing klebsiella pneumoniae bloodstream infections: should we get to the pk/pd root of the paradox? | the objective of this study was to assess the achievement of pharmacokinetic/pharmacodynamic (pk/pd) targets of meropenem (mem) in critically-ill patients with bloodstream infections (bsi) due to klebsiella pneumoniae-carbapenemase-producing klebsiella pneumoniae (kpc-kp) with mem minimum inhibitory concentrations (mics) ≥16 mg/l. nineteen critically-ill patients with kpc-kp bsi were given combination therapy including mem, tigecycline, plus colistin or gentamicin (according to susceptibility te ... | 2017 | 27430122 |
| knowledge, attitudes, and beliefs regarding antimicrobial therapy and resistance among physicians in alexandria university teaching hospitals and the associated prescription habits. | irresponsible prescription of antimicrobials (ams) is the driving factor for the growing antimicrobial resistance (amr) crisis. in this study, we assessed the knowledge, attitudes, perceptions, and beliefs regarding ams and amr together with the prescription habits of physicians in three university hospitals in alexandria, egypt. a 40-question survey was used. physicians were stratified into residents and practicing staff members, and further into various departments. clinical pharmacists at the ... | 2017 | 27092847 |
| computed tomography features of septic pulmonary embolism caused by klebsiella pneumoniae liver abscess associated with extrapulmonary metastatic infection. | the aims of the study were to investigate the computed tomography (ct) features and clinical course of septic pulmonary embolism (spe) caused by klebsiella pneumoniae liver abscess (kpla) and to explore the possible mechanism underlying the spread of infection. | 2017 | 26938693 |
| emergence and interhospital spread of oxa-48-producing klebsiella pneumoniae st395 clone in western hungary. | 2017 | 27465499 | |
| a retrospective study of the changing trends of antimicrobial resistance of klebsiella pneumoniae isolated from urine samples over last 3 years (2012-2014). | in our country, the problem of antibiotic resistance is compounding because of overuse and misuse of antibiotics. there is no systematic national surveillance of antibiotic resistance and insufficient data are available to quantify the problem. | 2017 | 27003967 |
| detection of oxa-48-like and ndm carbapenemases producing klebsiella pneumoniae in jordan: a pilot study. | little is known of carbapenemase producing klebsiella pneumoniae (cpk) in jordan. this study aimed to determine the prevalence of cpk in a major hospital in amman, jordan in 2012-2013 and to characterize the isolates and detect the types of carbapenemase(s) they produced. for the 296 isolates investigated, species identification and antimicrobial susceptibilities were determined (vitek ii, biomérieux). isolates with decreased ertapenem susceptibility were tested for carbapenemase production usin ... | 2017 | 26993738 |
| virulence and antimicrobial resistance of common urinary bacteria from asymptomatic students of niger delta university, amassoma, bayelsa state, nigeria. | asymptomatic bacteriuria frequently occurs among all ages with the possibility of developing into urinary tract infections, and the antimicrobial resistance patterns of the etiologic organisms are essential for appropriate therapy. thus, we investigated the virulence and antimicrobial resistance patterns of common urinary bacteria in asymptomatic students of niger delta university, amassoma, bayelsa state, nigeria in a cross-sectional study. | 2017 | 26957865 |
| molecular detection and antimicrobial resistance of klebsiella pneumoniae from house flies (musca domestica) in kitchens, farms, hospitals and slaughterhouses. | identifying disease vectors and pathogens is one of the key steps in controlling vector-borne diseases. this study investigated the possible role of house flies (musca domestica) as vectors in the transmission of klebsiella pneumoniae in chaharmahal va bakhtiari and isfahan provinces of iran. house flies were captured from household kitchens, cattle farms, chicken farms, animal hospitals, human hospitals and slaughterhouses. isolation of k. pneumoniae from external surfaces and guts of the flies ... | 2017 | 26876433 |
| phenotypic determination of carbapenemase producing enterobacteriaceae isolates from clinical specimens at a tertiary hospital in lagos, nigeria. | carbapenemase production among clinical isolates of enterobacteriaceae has been widely reported with prevalence rates ranging from between 2.8% and 53.6%. the aim of this study was to assess the prevalence of carbapenemase production among clinical isolates of enterobacteriaceae from a tertiary hospital in lagos, nigeria, and to characterize the type of carbapenemase produced. | 2017 | 26776335 |
| [molecular characterization of an outbreak of carbapenem-resistant klebsiella pneumoniae in a tertiary care hospital in medellín, colombia]. | resistance to carbapenems is considered to represent a serious threat to public health at the global level, since these antibiotics are one of the last therapeutic options for the treatment of multidrug-resistant bacteria. molecular characterization of outbreaks due to resistant bacteria provides information that can be used in the design of infection control strategies. | 2017 | 26844438 |
| klebsiella pneumoniae liver abscess and metastatic endophthalmitis. | introduction. klebsiella pneumoniae is a well-known cause of liver abscess. higher rates of liver abscess associated with klebsiella pneumoniae are seen in taiwan. metastatic endophthalmitis is a common complication associated with a poor prognosis despite aggressive therapy. case report. we report a case of a 67-year-old korean female with klebsiella pneumoniae liver abscess. the patient developed metastatic endophthalmitis and ultimately succumbed to her disease despite aggressive medical and ... | 2017 | 26788530 |
| septic knee arthritis in crohn's disease biological therapy-free patient. case report. | a 52-year-old woman with crohn's disease presented with septic arthrtis of the knee. this condition coincided with a symptomatic flare of her crohn's disease due to an ileal inflammatory stenosis, manifested as a phlegmonous mass palpable in the right lower quadrant and a small bowel obstruction. results of synovial fluid cultures showed the presence of gram-negative bacillus, klebsiella pneumoniae and the ct scan images were highly suggestive of abdominal abscess within crohn's disease. the pat ... | 2017 | 26664477 |
| hemodialysis catheter heat transfer for biofilm prevention and treatment. | central line-associated bloodstream infections (clabsis) are not easily treated, and many catheters (e.g., hemodialysis catheters) are not easily replaced. biofilms (the source of infection) on catheter surfaces are notoriously difficult to eradicate. we have recently demonstrated that modest elevations of temperature lead to increased staphylococcal susceptibility to vancomycin and significantly soften the biofilm matrix. in this study, using a combination of microbiological, computational, and ... | 2017 | 26501916 |
| hepatic metastasis complicated by abscess formation. | hepatic abscesses and hepatic metastasis are common diseases. however, hepatic abscesses seldom occur in patients with hepatic metastases. we describe a case of a 67-year-old female patient with abdominal pain in the right upper quadrant. magnetic resonance imaging revealed several lesions, with the largest lesion displaying features of both hepatic pyogenic abscess and liver metastasis. these features included iso- or hypointense signaling on t1wi and t2wi, hyperintense signaling on diffusion w ... | 2017 | 26430451 |
| antimicrobial susceptibility pattern of extended-spectrum beta- lactamase producing klebsiella pneumoniae clinical isolates in an indian tertiary hospital. | there is an increased prevalence of extended-spectrum beta-lactamase producing klebsiella pneumoniae (esbl-kp) worldwide including india, which is a major concern for the clinicians, especially in intensive care units and pediatric patients. this study aims to determine the prevalence of esbl-kp and antimicrobial sensitivity profile to plan a proper hospital infection control program to prevent the spread of resistant strains. | 2017 | 26312255 |
| klebsiella pneumoniae in septicemic neonates with special reference to extended spectrum β-lactamase, ampc, metallo β-lactamase production and multiple drug resistance in tertiary care hospital. | β-lactamases viz., extended spectrum β-lactamase (esbl), ampc, and metallo β-lactamase (mbl) production in klebsiella pneumoniae has led to a serious concern about septicemic neonates in neonatal intensive care units due to high resistance against commonly used antimicrobials. | 2017 | 25949057 |
| plasmid-mediated antibiotic resistance and virulence in gram-negatives: the klebsiella pneumoniae paradigm. | plasmids harbor genes coding for specific functions including virulence factors and antibiotic resistance that permit bacteria to survive the hostile environment found in the host and resist treatment. together with other genetic elements such as integrons and transposons, and using a variety of mechanisms, plasmids participate in the dissemination of these traits resulting in the virtual elimination of barriers among different kinds of bacteria. in this article we review the current information ... | 2017 | 25705573 |
| klebsiella pneumoniae infection: a virulent cause of visual loss. | bacterial endophthalmitis is endogenous in 2-6% of cases and is frequently misdiagnosed initially. klebsiella pneumoniae is being increasingly recognised as an aggressive causative organism, and it is particularly prevalent in asian populations. we describe the case of a 71-year-old female of southeast asian origin with type 2 diabetes mellitus who presented with visual loss secondary to bacterial endophthalmitis and concomitant cerebral abscesses. imaging revealed the probable primary source of ... | 2017 | 25606041 |
| diversity of ammonia oxidation (amoa) and nitrogen fixation (nifh) genes in lava caves of terceira, azores, portugal. | lava caves are an understudied ecosystem in the subterranean world, particularly in regard to nitrogen cycling. the diversity of ammonia oxidation (amoa) and nitrogen fixation (nifh) genes in bacterial mats collected from lava cave walls on the island of terceira (azores, portugal) was investigated using denaturing gradient gel electrophoresis (dgge). a total of 55 samples were collected from 11 lava caves that were selected with regard to surface land use. land use types above the lava caves we ... | 2017 | 26778867 |
| healthcare associated infections caused by coagulase-negative staphylococci in a neonatal intensive care unit. | this study sought to evaluate infections related to health care caused by coagulase-negative staphylococci in a neonatal intensive care unit by assessing antimicrobial susceptibility profiles and potentially effective antibiotic regimens. | 2017 | 24213088 |
| microbiological and molecular characterization of extreme drug-resistant carbapenemase-producing klebsiella pneumoniae isolates. | fifteen klebsiella pneumoniae clinical isolates showing non-susceptibility to carbapenems and resistant to colistin were collected in an italian hospital. all isolates resulted negative to ampc, mbl and esbl production but positive to modified hodge test, therefore were evaluated as kpc producers. the presence of blakpc genes was verified by polymerase chain reaction (pcr) and sequencing. furthermore, molecular typing was performed by multilocus sequence typing (mlst). pcr analysis and nucleotid ... | 2017 | 24067478 |
| an unusual cause of acute abdomen-gas-forming liver abscess due to salmonella enteritidis. | gas-forming pyogenic liver abscess (gfpla) is considered to be a very severe form of pla and carries a high mortality. klebsiella pneumoniae is the most common pathogen responsible for the disease, whereas cases where salmonella is cited as the cause are very uncommon. we report the first case of a 53-year-old lady suffering from gfpla due to salmonella, who was successfully treated with surgical drainage. to the best of our knowledge, this is the first case of gfpla caused by salmonella enterit ... | 2017 | 23978428 |
| microbial tracking of multidrug-resistant klebsiella pneumoniae isolates in a pediatric hospital setting. | we investigated the clonal relatedness of seven multi-drug-resistant (mdr) klebsiella pneumoniae isolates, as well as three susceptible k. pneumoniae isolates collected during hospital outbreaks and outbreak-related microbiological surveillance, respectively. the relatedness among k. pneumoniae isolates was assessed by pulsed field gel electrophoresis (pfge) and automated repetitive-sequence-based pcr (rep-pcr) genotyping and the results were compared to a proteomic phenotyping performed by matr ... | 2017 | 23755761 |
| a survey on pulmonary pathogens and their antibiotic susceptibility among cystic fibrosis patients. | this study was performed to investigate frequency and antimicrobial susceptibility of pulmonary pathogens in cystic fibrosis (cf) patients. | 2017 | 22552452 |
| diversity of genotypes in ctx-m-producing klebsiella pneumoniae isolated in different hospitals in brazil. | the present study was undertaken to characterize ctx-m esbl-producing klebsiella pneumoniae collected from hospitals in different cities of brazil. | 2017 | 22230847 |
| klebsiella esbl bacteremia-mortality and risk factors. | extended spectrum β-lactamase (esbl)-producing bacteria have become recognized as a problem in south america. the aim of this study was to evaluate risk factors and mortality rate in bacteremia caused by esbl-producing klebsiella pneumoniae in a brazilian hospital. | 2017 | 22218521 |
| validity of somatic cell count as indicator of pathogen-specific intramammary infections. | the objective of this study was to determine whether somatic cell count (scc) was an effective test, with a sensitivity exceeding 85%, to determine species-specific bacterial infections. in addition, the relation between the scc and various udder pathogen groups was investigated. scc thresholds of greater than 200 000 cells/ml were used in quarter and greater than 150 000 cells/ml in composite milk samples. a retrospective study was conducted on a data set for 89 635 quarter and 345 467 composit ... | 2017 | 28470079 |
| chemical constituents of helichrysum italicum (roth) g. don essential oil and their antimicrobial activity against gram-positive and gram-negative bacteria, filamentous fungi and candida albicans. | the aerial parts of helichrysum italicum (roth) g. don were subjected to hydrodistillation to obtain essential oils which had been analyzed by gas chromatography and gas chromatography coupled with mass spectrometry and tested for antimicrobial activity against 12 bacteria, two yeasts and four fungi by agar diffusion method. the essential oil yielded 0.44% (v/w) and 67 compounds accounting for 99.24% of the oil were identified with a high content of oxygenated sesquiterpenes (61.42%). the most o ... | 2017 | 28725151 |
| arsenic-resistant and plant growth promoting firmicutes and γ-proteobacteria species from industrially polluted irrigation water and corresponding cropland. | the aim of the study was to explore irrigation water polluted with industrial waste and corresponding cropland to screen bacteria for as-detoxification and plant growth promotion. | 2017 | 28708308 |
| 1,1ꞌ-carbonyldiimidazole (cdi) mediated facile synthesis, structural characterization, antimicrobial activity and in-silico studies of coumarin-3-carboxamide derivatives. | despite of the availability of variety of antibacterial agents, re-emergance of pathogenic bacteria is still a serious medical concern. so, identification of new, safer, and selective antibacterial agents is the key interest in the medicinal chemistry research. | 2017 | 28641525 |
| cytotoxic and antimicrobial activities of cantharellus cibarius fr. (cantarellaceae). | antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of cantharellus cibarius were tested. broth microdilution assay was performed against 10 bacterial strains (staphylococcus aureus, s. epidermidis, micrococcus luteus, bacillus subtilis, enterococcus feacalis, escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, salmonella abony), with emphasis on helicobacter pylori. methanol extract was the most active against h. pylori strains wit ... | 2017 | 28613963 |
| in vitro antibacterial activity of poly (amidoamine)-g7 dendrimer. | nano-scale dendrimers are synthetic macromolecules that frequently used in medical and health field. traditional anibiotics are induce bacterial resistence so there is an urgent need for novel antibacterial drug invention. in the present study seventh generation poly (amidoamine) (pamam-g7) dendrimer was synthesized and its antibacterial activities were evaluated against representative gram- negative and gram-positive bacteria. | 2017 | 28583153 |
| biomedical applications of green synthesized nobel metal nanoparticles. | synthesis of nobel metal nanoparticles, play a key role in the field of medicine. plants contain a substantial number of organic constituents, like phenolic compounds and various types of glycosides that help in synthesis of metal nanoparticles. synthesis of metal nanoparticles by green method is one of the best and environment friendly methods. the major significance of the green synthesis is lack of toxic by-products produced during metal nanoparticle synthesis. the nanoparticles, synthesized ... | 2017 | 28582711 |
| pyranocarbazoles from murraya koenigii (l.) spreng. as antimicrobial agents. | the bioassay guided fractionation of methanolic extract of murraya koenigii (l.) spreng. leaves resulted in the isolation of seven pyranocarbazoles. these were evaluated against four bacterial strains and ten candida sp. including two matched pair of fluconazole sensitive/resistant clinical isolates. out of seven, three i.e. koenine (mk279), koenigine (mk309) and mahanine (mk347) exhibited significant antibacterial activity mic90 3.12-12.5 μg/ml against bacterial strains streptococcus aureus and ... | 2017 | 28368664 |
| inflammatory responses regulating alveolar ion transport during pulmonary infections. | the respiratory epithelium is lined by a tightly balanced fluid layer that allows normal o2 and co2 exchange and maintains surface tension and host defense. to maintain alveolar fluid homeostasis, both the integrity of the alveolar-capillary barrier and the expression of epithelial ion channels and pumps are necessary to establish a vectorial ion gradient. however, during pulmonary infection, auto- and/or paracrine-acting mediators induce pathophysiological changes of the alveolar-capillary barr ... | 2017 | 28458673 |
| antituberculotic activity of actinobacteria isolated from the rare habitats. | a distinctive screening procedure resulted in the isolation and identification of antituberculotic actinobacteria. in this course, a total of 125 actinobacteria were isolated from various soil samples from untapped areas in northwestern himalayas, india. the antibacterial screening showed that 26 isolates inhibited the growth of at least one of the tested bacterial pathogens including staphylococcus aureus (atcc 25923), staphylococcus epidermidis (atcc 12228), bacillus subtilis (atcc 11774), mic ... | 2017 | 28699251 |
| seven new lignan glycosides from the branches of alangium kurzii craib var. laxifolium. | seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of alangium kurzii craib var. laxifolium. their structures were established by spectroscopic analysis and circular dichroism (cd) and x-ray analysis. the isolated compounds were evaluated for their antibacterial activities against staphylococcus aureus ci1011, streptococcus suis ci1608, salmonella gallinarum ci0912, enterococcus faecalis ci1304, aeromonas hydrophila ci1008, escherichia coli ci1 ... | 2017 | 28733150 |
| antibacterial and antioxidant constituents of extracts of endophytic fungi isolated from ocimum basilicum var. thyrsiflora leaves. | fourteen fungal endophytes were isolated from the ocimum basilicum var. thyrsiflora leaves collected from northern thailand. eight genera were identified including aspergillus, ascochyta, nigrospora, blastomyces, colletotrichum, exidia, clitopilus, and nomuraea. the antibacterial activity of crude extracts from all endophytic fungi was tested against nine human bacterial pathogens: staphylococcus aureus, staphylococcus epidermidis, bacillus subtilis, bacillus cereus, escherichia coli, klebsiella ... | 2017 | 28698913 |
| variation analysis of bacterial polyhydroxyalkanoates production using saturated and unsaturated hydrocarbons. | polyhydroxyalkanoates (pha) are efficient, renewable and environment friendly polymeric esters. these polymers are synthesized by a variety of microbes under stress conditions. this study was carried out to check the suitability of waste frying oil in comparison to other oils for economical bioplastic production. six bacterial strains were isolated and identified as bacillus cereus (kf270349), klebsiella pneumoniae (kf270350), bacillus subtilis (kf270351), brevibacterium halotolerance (kf270352) ... | 2017 | 28629970 |
| investigation into the antimicrobial action and mechanism of a novel endogenous peptide β-casein 197 from human milk. | a novel endogenous peptide cleaved from 197-213 aa of β-casein, named β-casein 197, was identified by tandem mass spectrometry. β-casein 197 constituted a significant proportion of the peptide content in preterm milk. this study investigated the antibacterial effects and mechanisms against common pathogenic bacteria. six bacterial strains were selected for this study: escherichia coli, staphylococcus aureus, yersinia enterocolitica, listeria monocytogenes, klebsiella pneumonia and bacillus subti ... | 2017 | 28591979 |
| antibacterial activities of pyrenylated coumarins from the roots of prangos hulusii. | the dichloromethane extract of the roots of prangos hulusii, a recently described endemic species from turkey, has yielded nine known and one new prenylated coumarins. the structures were elucidated by spectroscopic methods and direct comparison with the reference compounds where available. the root extract and its prenylated coumarins exhibit antimicrobial activity against nine standard and six clinically isolated strains at a concentration between 5 and 125 µg/ml. in particular, the new coumar ... | 2017 | 28671568 |
| saccharomyces cerevisiae from brazilian kefir-fermented milk: an in vitro evaluation of probiotic properties. | the therapeutic use of probiotics for supporting the antibiotic action against gastrointestinal disorders is a current trend and emerging applications have gained popularity because of their support for various microbiological activities in digestive processes. microorganisms isolated from kefir with great probiotic properties, in addition to high resistance to harsh environmental conditions, have been widely researched. administration of probiotic yeasts offers a number of advantages, when comp ... | 2017 | 28478200 |
| conversion of glycerol to 3-hydroxypropanoic acid by genetically engineered bacillus subtilis. | 3-hydroxypropanoic acid (3-hp) is an important biomass-derivable platform chemical that can be converted into a number of industrially relevant compounds. there have been several attempts to produce 3-hp from renewable sources in cell factories, focusing mainly on escherichia coli, klebsiella pneumoniae, and saccharomyces cerevisiae. despite the significant progress made in this field, commercially exploitable large-scale production of 3-hp in microbial strains has still not been achieved. in th ... | 2017 | 28458661 |
| three new abietane-type diterpenoids from plectranthus africanus and their antibacterial activities. | three new abietane-type diterpenoids, plectranthroyleanones a - c (1 - 3), together with five known compounds (4 - 8) were isolated from the methanol extract of the whole plant of plectranthus africanus using column chromatography techniques. the structures of the new compounds were elucidated using a combination of 1d and 2d nmr and hresims analyses. compound 1 exhibited weak activities with minimal inhibitory concentration values of 75 µg/ml against gram-positive bacteria, bacillus subtilis an ... | 2017 | 28662528 |
| synthesis and characterization of mwcnt/tio2/au nanocomposite for photocatalytic and antimicrobial activity. | a novel combination of titanium oxide (tio2)/gold (au)/multiwalled carbon nanotubes (mwcnts) nanocomposite (nc) was synthesised by sol- gel method. mwcnt functionalisation by modified hummers method. tio2/au nanoparticles (nps) were synthesised by biological method using terminalia chebula bark extract. mwcnt/tio2/au nc samples were characterised by x-ray diffraction, ultraviolet-visible-diffuse reflectance spectra, microraman, scanning electron microscopy and high-resolution-transmission electr ... | 2017 | 28476971 |
| silver nanoparticles mediated by costus afer leaf extract: synthesis, antibacterial, antioxidant and electrochemical properties. | synthesis of metallic and semiconductor nanoparticles through physical and chemical routes has been extensively reported. however, green synthesized metal nanoparticles are currently in the limelight due to the simplicity, cost-effectiveness and eco-friendliness of their synthesis. this study explored the use of aqueous leaf extract of costus afer in the synthesis of silver nanoparticles (ca-agnps). the optical and structural properties of the resulting silver nanoparticles were studied using uv ... | 2017 | 28468278 |
| identification and growth optimization of a marine bacillus dk1-sa11 having potential of producing broad spectrum antimicrobial compounds. | control of harmful bacteria in food, aquaculture, pharmaceuticals, agriculture, hospitals and recreation water pools are of great global concern. marine bacteria are an enormous source of bio-controlling agents. the aim of this study was to identify and optimize the growth conditions including effect of different biotic and abiotic factors on antimicrobial activity of strain dk1-sa11 isolated from qingdao bay of china yellow sea. microscopic characterization, api® 20e and 50 chb kit base carbohy ... | 2017 | 28653930 |
| syntheses of benzophenone-xanthone hybrid polyketides and their antibacterial activities. | muchimangins are benzophenone-xanthone hybrid polyketides produced by securidaca longepedunculata. however, their biological activities have not been fully investigated, since they are minor constituents in this plant. to evaluate the possibility of muchimangins as antibacterial agent candidates, five muchimangin analogs were synthesized from 2,4,5-trimethoxydiphenyl methanol and the corresponding xanthones, by utilizing p-toluenesulfonic acid monohydrate for the brønsted acid-catalysis. the ant ... | 2017 | 28416134 |
| bacteriology of peritonsillar abscess: the changing trend and predisposing factors. | peritonsillar abscess (pta) is the most common deep neck infection. the infectious microorganism may be different according to clinical factors. | 2017 | 28756939 |
| isolation, purification, and characterization of five active diketopiperazine derivatives from endophytic streptomyces suk 25 with antimicrobial and cytotoxic activities. | in our search for new sources of bioactive secondary metabolites from streptomyces sp., the ethyl acetate extracts from endophytic streptomyces suk 25 afforded five active diketopiperazine (dkp) compounds. the aim of this study was to characterize the bioactive compounds isolated from endophytic streptomyces suk 25 and evaluate their bioactivity against multiple drug resistance (mdr) bacteria such as enterococcus raffinosus, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumanii, p ... | 2017 | 28535606 |
| bioactive molecule from streptomyces sp. mitigates mdr klebsiella pneumoniae in zebrafish infection model. | the emergence and spread of multi-drug resistant (mdr) especially carbapenem-resistant klebsiella pneumoniae is a major emerging threat to public health, leading to excess in mortality rate as high as 50-86%. mdr k. pneumoniae manifests all broad mechanisms of drug resistance, hence development of new drugs to treat mdr k. pneumoniae infection has become a more relevant question in the scientific community. in the present study a potential streptomyces sp. ask2 was isolated from rhizosphere soil ... | 2017 | 28446900 |
| first case report of non-human primates (alouatta clamitans) with the hypervirulent klebsiella pneumoniae serotype k1 strain st 23: a possible emerging wildlife pathogen. | hypervirulent strain of klebsiella pneumoniae genotype k1 isolates have recently emerged, causing severe pyogenic liver abscess complicated by devastating metastatic infections in humans. | 2017 | 28809435 |
| septicemic invasive klebsiella pneumoniae infection in a cynomolgus monkey (macaca fascicularis) with severe diffused suppurative meningoencephalitis. | a 2-year-old male cynomolgus monkey (macaca fascicularis) showed neurological symptoms during quarantine for importation into japan, and was euthanized due to poor prognosis. gross anatomical examination revealed a hemorrhagic lesion around the lateral ventricle in the cerebrum. histologically, severe diffused suppurative meningitis and ventriculitis were detected with numerous gram-negative bacilli in the cerebrum. immunohistochemically, the bacilli were positively stained with an antibody agai ... | 2017 | 28529273 |
| sensitivity to antibiotics of bacteria exposed to gamma radiation emitted from hot soils of the high background radiation areas of ramsar, northern iran. | over the past several years our laboratories have investigated different aspects of the challenging issue of the alterations in bacterial susceptibility to antibiotics induced by physical stresses. | 2017 | 28432369 |
| antibacterial effects of lactobacillus isolates of curd and human milk origin against food-borne and human pathogens. | this study was undertaken to assess the antibacterial efficacy of lactobacilli isolated from curd and human milk samples. identities of thirty-one different lactobacilli (20 from curd and 11 from human milk) were confirmed by genus-specific pcr and 16s rrna-based sequencing. these strains belonged to five species, lactobacillus casei, l. delbrueckii, l. fermentum, l. plantarum, and l. pentosus. antibacterial activities of cell-free supernatants (cfss) of all the lactobacillus isolates were estim ... | 2017 | 28401466 |
| current problematic and emergence of carbapenemase-producing bacteria: a brief report from a libyan hospital. | a collection of 94 gram-negative bacteria isolates, showing different antimicrobial resistance phenotypes including to the carbapenem classes was investigated. strains were originated form clinical sources from a single hospital in tripoli, libya during 2015 and were identified based on cultural and phenotypic characteristics, and fully characterized by the vitek automated system. forty-eight percent (48%) of the collection was identified as acinetobacter baumannii, 50% klebsiella pneumoniae and ... | 2017 | 28674573 |
| bacterial and histopathological findings in deep head and neck infections: a retrospective analysis. | deep neck infections are among the most dangerous acute diseases in the head and neck region. this analysis gives an overview of the bacterial and histopathologic findings of deep neck infections. | 2017 | 28411005 |
| application of maldi-tof ms fingerprinting as a quick tool for identification and clustering of foodborne pathogens isolated from food products. | foodborne pathogens can be associated with a wide variety of food products and it is very important to identify them to supply safe food and prevent foodborne infections. since traditional techniques are time-consuming and laborious, this study was designed for rapid identification and clustering of foodborne pathogens isolated from various restaurants in al-qassim region, kingdom of saudi arabia (ksa) using matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ... | 2017 | 28825446 |
| antimicrobial activity of octenidine against multidrug-resistant gram-negative pathogens. | multidrug-resistant (mr) gram-negative (gn) pathogens pose a major and growing threat for healthcare systems, as therapy of infections is often limited due to the lack of available systemic antibiotics. well-tolerated antiseptics, such as octenidine dihydrochloride (oct), may be a very useful tool in infection control to reduce the dissemination of mrgn. this study aimed to investigate the bactericidal activity of oct against international epidemic clones of mrgn. a set of five different species ... | 2017 | 28825186 |
| device-associated healthcare-associated infections (da-hai) and the caveat of multiresistance in a multidisciplinary intensive care unit. | device-associated healthcare-associated infections (da-hai), including ventilator-associated pneumonia (vap), central-line-associated blood stream infection (clabsi), and catheter-related urinary tract infection (cauti), are considered as principal contributors to healthcare hazard and threat to patient safety as they can cause prolonged hospital stay, sepsis, and mortality in the icu. the study intends to characterize da-hai in a tertiary care multidisciplinary icu of a teaching hospital in eas ... | 2017 | 28790779 |
| patterns of multi-drug resistant bacteria at first culture from patients admitted to a third level university hospital in calabria from 2011 to 2014: implications for empirical therapy and infection control. | surveillance of antimicrobial drug resistance is fundamental to guide empirical treatment. however, the european antimicrobial resistance surveillance network provides a general picture, which might not be applicable to clinical settings that are excluded from this survey. we evaluated resistance patterns of eskape isolates over a four-year period in a third level university hospital in the province of catanzaro (southern italy). in this retrospective study, we evaluated the frequency of eskape ... | 2017 | 28603227 |
| antimicrobial activity, toxicity and anti-inflammatory potential of methanolic extracts of four ethnomedicinal plant species from punjab, pakistan. | the plant species aristolochia indica (ai), melilotus indicus (mi), tribulus terrestris (tt) and cuscuta pedicellata (cp) are widely used in folk medicine in the villages around chowk azam, south punjab, pakistan. the aim of this study was to evaluate the antioxidant activity, phytochemical composition, and the antibacterial, antifungal, cytotoxic and anti-inflammatory potential of the four medicinal plants listed above. for cp stem, this study represents (to the best of our knowledge) the first ... | 2017 | 28595608 |
| risk factors and predictors of carbapenem-resistant pseudomonas aeruginosa and acinetobacter baumannii mortality in critically ill bacteraemic patients over a 6-year period (2010-15): antibiotics do matter. | acinetobacter baumannii and pseudomonas aeruginosa provoke serious infections, especially in intensive care unit (icu) patients. | 2017 | 28758623 |
| evaluation of the in vitro antimicrobial activity of selected saudi scorpion venoms tested against multidrug-resistant micro-organisms. | scorpion venoms are a rich source of bioactive peptides with promising clinical value that may lead to the discovery and development of new drugs. the present study was designed to evaluate the in vitro antimicrobial activities of the venoms extracted from three medically important saudi scorpions (androctonus crassicauda, androctonus bicolor and leiurus quinquestriatus). | 2017 | 28587870 |
| bacteria from animals as a pool of antimicrobial resistance genes. | antimicrobial agents are used in both veterinary and human medicine. the intensive use of antimicrobials in animals may promote the fixation of antimicrobial resistance genes in bacteria, which may be zoonotic or capable to transfer these genes to human-adapted pathogens or to human gut microbiota via direct contact, food or the environment. this review summarizes the current knowledge of the use of antimicrobial agents in animal health and explores the role of bacteria from animals as a pool of ... | 2017 | 28587316 |
| antimicrobial efficacy and synergy of metal ions against enterococcus faecium, klebsiella pneumoniae and acinetobacter baumannii in planktonic and biofilm phenotypes. | the effects of metal ion solutions (silver, copper, platinum, gold and palladium) were determined individually and in combination against enterococcus faecium, acinetobacter baumannii and klebsiella pneumoniae. platinum, gold and palladium showed the greatest antimicrobial efficacy in zone of inhibition (zoi) assays. when tested in combinations using zoi assays, gold/platinum, gold/palladium and platinum/palladium were indicative of synergy. microbial inhibitory concentration demonstrated platin ... | 2017 | 28724953 |
| titanium surfaces immobilized with the major antimicrobial fragment fk-16 of human cathelicidin ll-37 are potent against multiple antibiotic-resistant bacteria. | infections on implanted medical devices are a challenging problem, especially when bacteria form difficult-to-treat biofilms. antimicrobial peptides are considered to be a solution due to their potency against antibiotic-resistant superbugs. previously, the authors' laboratory demonstrated the prevention of staphylococcal biofilm formation in an animal catheter model by injecting merecidin (formerly known as 17biphe2), a peptide engineered based on the only human cathelicidin. this study documen ... | 2017 | 28675109 |
| genomic epidemiology of ndm-1-encoding plasmids in latin american clinical isolates reveals insights into the evolution of multidrug resistance. | bacteria that produce the broad-spectrum carbapenem antibiotic new delhi metallo-β-lactamase (ndm) place a burden on health care systems worldwide, due to the limited treatment options for infections caused by them and the rapid global spread of this antibiotic resistance mechanism. although it is believed that the associated resistance gene blandm-1 originated in acinetobacter spp., the role of enterobacteriaceae in its dissemination remains unclear. in this study, we used whole genome sequenci ... | 2017 | 28854628 |
| comparison of a new matrix-assisted laser desorption/ionization time-of-flight mass spectrometry platform, asta microidsys, with bruker biotyper for species identification. | matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, with its accuracy and speed, is widely used for bacterial identification. the asta microidsys system (asta, korea) was recently developed for species identification. we compared its performance with that of bruker biotyper (bruker daltonics, germany). microbes were recovered from sputum, urine, and pus samples from patients admitted to a tertiary care hospital in korea from january to april 2016. matrix solution (α-cya ... | 2017 | 28840993 |
| membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards gram-negative bacteria. | chronic bacterial biofilms place a massive burden on healthcare due to the presence of antibiotic-tolerant dormant bacteria. some of the conventional antibiotics such as erythromycin, vancomycin, linezolid, rifampicin etc. are inherently ineffective against gram-negative bacteria, particularly in their biofilms. here, we report membrane-active macromolecules that kill slow dividing stationary-phase and antibiotic tolerant cells of gram-negative bacteria. more importantly, these molecules potenti ... | 2017 | 28837596 |
| polymyxins for cns infections: pharmacology and neurotoxicity. | central nervous system (cns) infections caused by multi-drug resistant (mdr) gram-negative bacteria present a major health and economic burden worldwide. due to the nearly empty antibiotic discovery pipeline, polymyxins (i.e. polymyxin b and colistin) are used as the last-line therapy against gram-negative 'superbugs' when all other treatment modalities have failed. the treatment of cns infections due to multi-drug resistant gram-negative bacteria is problematic and associated with high mortalit ... | 2017 | 28750947 |
| the respiratory threat posed by multidrug resistant gram-negative bacteria. | respiratory infections are a major cause of global mortality and morbidity. in recent years, an increased incidence of multidrug-resistant (mdr) gram-negative bacteria (gnb) has been described. microorganisms such as pseudomonas aeruginosa, escherichia coli, klebsiella pneumoniae or acinetobacter baumannii have been identified as causative pathogens of different respiratory tract infections. several studies have detected mdr-gnb in patients with community-acquired and nosocomial pneumonia. furth ... | 2017 | 28681941 |
| bad bacteria in acute appendicitis: rare but relevant. | bacterial infections are a factor for morbidity in patients with acute appendicitis (aa). the spreading of multidrug-resistant (mdr) bacteria is a significant problem in surgery, and the most relevant mdr pathogens are summarized as enterobacteriaceae, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterococci (eskape) bacteria. data regarding the species and distribution of bacteria in aa are available, but information about the resistances an ... | 2017 | 28710611 |
| clinical characteristics and epidemiology of sepsis in the neonatal intensive care unit in the era of multi-drug resistant organisms: a retrospective review. | sepsis in the neonatal intensive care unit (nicu) remains one of the most significant causes of morbidity and mortality, especially for preterm newborns. multi-drug resistant organisms (mdros) are emerging as important pathogens that cause neonatal sepsis in nicu. therefore, studying the epidemiology, clinical features, and outcome caused by mdros vs. non-mdros, and identifying risk factors that may predispose patients to sepsis by mdros are important. | 2017 | 28642139 |
| simple and fast detection of resistance to antibiotic inhibitors of protein synthesis in gram-negative pathogens through evaluation of mitomycin c-induced cell elongation. | increasing the resistance of gram-negative pathogens to antibiotics that inhibit protein synthesis is of great concern. in life-threatening situations, an early detection of antibiotic resistance may improve patient outcome. a rapid assay for the identification of antibiotic resistance to gentamicin, tobramycin, and tigecycline has been designed and tested in clinical strains of acinetobacter baumannii, pseudomonas aeruginosa, and the enterobacteriaceae escherichia coli and klebsiella pneumoniae ... | 2017 | 28467172 |
| the distribution of carbapenem- and colistin-resistance in gram-negative bacteria from the tamil nadu region in india. | the occurrence of carbapenem- and colistin-resistance among gram-negative bacteria is increasing worldwide. the aim of this study was to understand the distribution of carbapenem- and colistin-resistance in two areas in tamil nadu, india. | 2017 | 28671537 |
| targeted surveillance and infection-related risk factors of nosocomial infection in patients after neurosurgical operation. | the purpose of this study was to investigate the risk factors of nosocomial infection in patients after neurosurgical operations, so as to provide reasonable, effective preventative measures in the future. a total of 1,600 patients with brain tumors, hydrocephalus, craniocerebral trauma and vascular disease treated in the neurosurgery room were chosen for targeted surveillance; and through analysis on the clinical data of patients, the incidence of nosocomial infection, the site of infection and ... | 2017 | 28671080 |
| extended-spectrum beta-lactamase producing gram negative bacteria in iran: a review. | the emergence and spread of extended spectrum β-lactamase (esbl)-producing gram- negative bacteria (gnb), particularly in enterobacteriaceae, acinetobacter baumannii, and pseudomonas aeruginosa, have increased all over the world. esbls are characterized by their ability to hydrolyze β-lactams, early cephalosporins, oxyimino-thiazolyl cephalosporins, and monobactams, but not cephamycins or carbapenems. the rate of nosocomial infections caused by esbl-producing gnb in asia pacific has increased an ... | 2017 | 28670639 |
| inhaled colistin monotherapy for respiratory tract infections in adults without cystic fibrosis: a systematic review and meta-analysis. | inhaled colistin is becoming increasingly popular against respiratory tract infections due to multidrug resistant (mdr) gram-negative bacteria since it may overcome the problems associated with iv administration. | 2017 | 28669836 |
| occurrence of carbapenemase-producing enterobacteriaceae isolates in the wildlife: first report of oxa-48 in wild boars in algeria. | the aim of the present study was to screen for the presence of carbapenemase-producing enterobacteriaceae (cpe) isolates from wild boars and barbary macaques in algeria. fecal samples were collected from wild boars (n = 168) and barbary macaques (n = 212), in bejaia, algeria, between september 2014 and april 2016. the isolates were identified and antimicrobial susceptibility was determined. carbapenem resistance determinants were studied using pcr and sequencing, while clonal relatedness was per ... | 2017 | 28799835 |
| potentiation of antibiotic activity by a novel cationic peptide: potency and spectrum of activity of spr741. | novel approaches for the treatment of multidrug-resistant gram-negative bacterial infections are urgently required. one approach is to potentiate the efficacy of existing antibiotics whose spectrum of activity is limited by the permeability barrier presented by the gram-negative outer membrane. cationic peptides derived from polymyxin b have been used to permeabilize the outer membrane, granting antibiotics that would otherwise be excluded access to their targets. we assessed the in vitro effica ... | 2017 | 28533232 |
| a genoproteomic approach to detect peptide markers of bacterial respiratory pathogens. | rapid identification of respiratory pathogens may facilitate targeted antimicrobial therapy. direct identification of bacteria in bronchoalveolar lavage (bal) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is confounded by interfering substances. we describe a method to identify unique peptide markers of 5 gram-negative bacteria by liquid chromatography-tandem mass spectrometry (lc-ms/ms) for direct pathogen identification in bal. | 2017 | 28588123 |
| cluster-distinguishing genotypic and phenotypic diversity of carbapenem-resistant gram-negative bacteria in solid-organ transplantation patients: a comparative study. | solid-organ transplant recipients may display high rates of colonization and/or infection by multidrug-resistant bacteria. we analysed and compared the phenotypic and genotypic diversity of carbapenem-resistant (cr) strains of klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumannii isolated from patients in the solid organ transplantation department of our hospital. | 2017 | 28758635 |
| properties of probiotics kocuria sm1 and rhodococcus sm2 isolated from fish guts. | this study characterized probiotics kocuria sm1 and rhodococcus sm2, which were recovered from the intestinal microbiota of rainbow trout (oncorhynchus mykiss, walbaum). the cultures were gram-positive, non-motile, catalase-positive and oxidase-negative cocci or rods. cell multiplication of sm1 and sm2 was observed at 4-37 °c (45 °c for sm1), in 0-20% (w/v) nacl and at ph 2-11. the viability was not affected when exposed to pepsin at ph 2.0 and 3.0, and pancreatin at ph 8.0. neither isolates wer ... | 2017 | 28585158 |
| occurrence of the mcr-1 colistin resistance gene and other clinically relevant antibiotic resistance genes in microbial populations at different municipal wastewater treatment plants in germany. | seven wastewater treatment plants (wwtps) with different population equivalents and catchment areas were screened for the prevalence of the colistin resistance gene mcr-1 mediating resistance against last resort antibiotic polymyxin e. the abundance of the plasmid-associated mcr-1 gene in total microbial populations during water treatment processes was quantitatively analyzed by qpcr analyses. the presence of the colistin resistance gene was documented for all of the influent wastewater samples ... | 2017 | 28744270 |
| an unusual culprit: klebsiella pneumoniae causing septicaemia outbreaks in neonatal pigs? | this study investigated the cause of recent outbreaks of septicaemia in neonatal pigs in australia (victoria and queensland). septicaemia in neonatal pigs is commonly caused by enterotoxigenic e. coli, extraintestinal pathogenic e. coli and beta-haemolytic streptococci. infrequent causes of septicaemia are actinobacillus suis and citrobacter freundii. therefore, it was quite unexpected when klebsiella pneumoniae was isolated in predominant growth from multiple organs of pigs dying of septicaemia ... | 2017 | 28619154 |
| differences in antimicrobial consumption, prescribing and isolation rate of multidrug resistant klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumannii on surgical and medical wards. | in order to provide guidance data for clinically rational use of an antibiotics consuption, prescribing and prevalence of multidrug resistant (mdr) klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumannii were monitored on the surgical (s) and medical (m) wards of the university hospital center "dr. dragisa misovic-dedinje" (belgrade, serbia), in the study period from 2012 to 2015. appropriateness of antimicrobial use was evaluated using the global-prevalence survey method desig ... | 2017 | 28467437 |
| development of silver nanoparticles loaded chitosan-alginate constructs with biomedical potentialities. | herein, a facile biosynthesis of silver nanoparticles (agnps) and agnps-loaded chitosan-alginate constructs with biomedical potentialities is reported. the uv-vis spectroscopic profile confirmed the synthesis of agnps using methanolic leaves extract of euphorbia helioscopia. the newly developed agnps were characterized using various analytical and imaging techniques including uv-vis and ft-ir spectroscopy, x-ray diffraction (xrd), scanning electron microscopy (sem), energy dispersive spectroscop ... | 2017 | 28705499 |
| recovery of metallo-tolerant and antibiotic resistant psychrophilic bacteria from siachen glacier, pakistan. | cultureable bacterial diversity of previously unexplored siachen glacier, pakistan, was studied. out of 50 isolates 33 (66%) were gram negative and 17 (34%) gram positive. about half of the isolates were pigment producers and were able to grow at 4-37°c. 16s rrna gene sequences revealed gram negative bacteria dominated by proteobacteria (especially γ-proteobacteria and β-proteobacteria) and flavobacteria. the genus pseudomonas (51.51%, 17) was dominant among γ- proteobacteria. β-proteobacteria c ... | 2017 | 28746396 |
| biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype. | bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (mdros). nevertheless, a quantitative correlation between biofilm production and the profile of antimicrobial drug resistance in delayed wound healing remains to be determined. microbial identification, antibiotic susceptibility and biofilm production were assessed in 135 clinical isolates from 87 patients. gram-negative bacteria were ... | 2017 | 28513576 |
| characteristics of meningitis following transsphenoidal endoscopic surgery: a case series and a systematic literature review. | meningitis occurs in 0.8-1.5% of patients undergoing neurosurgery. the aim of the study was to evaluate the characteristics of meningitis after endoscopic endonasal transsphenoidal surgery (eets) comparing the findings retrieved to those highlighted by literature search. | 2017 | 28776163 |
| antimicrobial activity of endophytic bacterial populations isolated from medical plants of iran. | endophytic actinobacteria colonize inside the plant tissues without causing damages to the host plant. since these microorganisms colonize in the different parts of plants and can stop plant disease, they have been applied as biological agents for controlling human diseases. the aim of this study was molecular identification and measuring the antimicrobial activity of endophytic actinomycetes isolated from medicinal plants of iran. | 2017 | 28775818 |
| cyclohexene-fused 1,3-oxazines with selective antibacterial and antiparasitic action and low cytotoxic effects. | oxazine derivatives, a class of heterocyclic compounds, exhibit a variety of biological properties, such as anticonvulsant and antitumor activities. in this study, we evaluated the effect of two cyclohexene-fused 1,3-oxazines (cis‑1-benzyl-n-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (1) and trans‑n-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (2)) in cultures of bacillus cereus, enterococcus faecalis, escherichia coli, klebsiella pneumoniae, salmonella enterica, serratia mar ... | 2017 | 28755871 |
| nonribosomal peptide synthetase biosynthetic clusters of eskape pathogens. | covering: up to 2017.natural products are important secondary metabolites produced by bacterial and fungal species that play important roles in cellular growth and signaling, nutrient acquisition, intra- and interspecies communication, and virulence. a subset of natural products is produced by nonribosomal peptide synthetases (nrpss), a family of large, modular enzymes that function in an assembly line fashion. because of the pharmaceutical activity of many nrps products, much effort has gone in ... | 2017 | 28642945 |
| an enhancement of antimicrobial efficacy of biogenic and ceftriaxone-conjugated silver nanoparticles: green approach. | of the various methods explored for the synthesis of nanoparticles, biogenesis of silver nanoparticles (agnps) received great attention due to their versatile properties. in this report, daucus carota extract was used for the synthesis of agnps and ceftriaxone was conjugated with agnps to enhance their antimicrobial efficacy. the conjugated and unconjugated agnps were characterized by adopting uv-vis spectroscopy, ftir, afm, dls, and tem, which revealed the spr peak at 420 nm and spherical shape ... | 2017 | 28600792 |