Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| evaluation of the synergistic effect of mixed cultures of white-rot fungus pleurotus ostreatus and biosurfactant-producing bacteria on ddt biodegradation. | ddt (1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane) is one of the organic synthetic pesticides that has many negative effects for human health and the environment. the purpose of this study was to investigate the synergistic effect of mixed cutures of white-rot fungus, pleurotus ostreatus, and biosurfactant-producing bacteria, pseudomonas aeruginosa and bacillus subtilis, on ddt biodegradation. bacteria was added into p. ostreatus culture (mycelial wet weight on average by 8.53 g) in concentrat ... | 2017 | 28434213 |
| genotypic diversity among multidrug resistant pseudomonas aeruginosa and acinetobacter species at mulago hospital in kampala, uganda. | multidrug resistant pseudomonas aeruginosa and acinetobacter species are common causes of nosocomial infections worldwide. recently we reported the occurrence of carbapenem resistant enterobacteriaceae, p. aeruginosa and acinetobacter species at mulago national referral hospital in kampala, uganda, but the isolates were not analyzed for genetic relatedness. herein we report the intra-species genotypic diversity among p. aeruginosa and acinetobacter baumannii isolated from hospitalized patients a ... | 2017 | 28705201 |
| carbapenemase detection among carbapenem-resistant glucose-nonfermenting gram-negative bacilli. | accurate detection of carbapenemase-producing glucose-nonfermenting gram-negative bacilli (cpnfs), including pseudomonas aeruginosa and acinetobacter baumannii, is necessary to prevent their dissemination within health care settings. we performed a method comparison study of 11 phenotypic carbapenemase detection assays to evaluate their accuracy for the detection of cpnfs. a total of 96 carbapenem-resistant glucose-nonfermenting isolates were included, of which 29% produced carbapenemases. all c ... | 2017 | 28701421 |
| antimicrobial susceptibility among gram-positive and gram-negative organisms collected from the latin american region between 2004 and 2015 as part of the tigecycline evaluation and surveillance trial. | the in vitro activity of tigecycline and comparator agents was evaluated against gram-positive and gram-negative isolates collected in latin american centers between 2004 and 2015 as part of the tigecycline evaluation and surveillance trial (t.e.s.t.) global surveillance study. | 2017 | 28701170 |
| impact of broad-spectrum antimicrobial treatment on the ecology of intestinal flora. | suppression of intestinal flora by broad-spectrum antimicrobial agents facilitated risk of colonization or infection with resistant pathogen. we aimed to investigate the changes in bowel carriage of target resistant microorganisms (tro) among patients treated with three different classes of pseudomonas-sparing broad-spectrum antimicrobial agents (ertapenem, moxifloxacin and flomoxef) with anaerobic coverage. risk factors for developing colonization of tro were also analyzed. | 2017 | 28693929 |
| comparison of in-house and commercial real time-pcr based carbapenemase gene detection methods in enterobacteriaceae and non-fermenting gram-negative bacterial isolates. | carbapenemase-producing gram-negative bacteria are increasing globally and have been associated with outbreaks in hospital settings. thus, the accurate detection of these bacteria in infections is mandatory for administering the adequate therapy and infection control measures. this study aimed to establish and evaluate a multiplex real-time pcr assay for the simultaneous detection of carbapenemase gene variants in gram-negative rods and to compare the performance with a commercial rt-pcr assay ( ... | 2017 | 28693493 |
| investigation and analysis of the characteristics and drug sensitivity of bacteria in skin ulcer infections. | skin ulcer is a common type of disease affecting patients' health and quality of life, and bacterial infection increases the difficulty of its management. | 2017 | 28689800 |
| the respiratory threat posed by multidrug resistant gram-negative bacteria. | respiratory infections are a major cause of global mortality and morbidity. in recent years, an increased incidence of multidrug-resistant (mdr) gram-negative bacteria (gnb) has been described. microorganisms such as pseudomonas aeruginosa, escherichia coli, klebsiella pneumoniae or acinetobacter baumannii have been identified as causative pathogens of different respiratory tract infections. several studies have detected mdr-gnb in patients with community-acquired and nosocomial pneumonia. furth ... | 2017 | 28681941 |
| assessment of surgical risk factors in the development of ventilator-associated pneumonia in neurosurgical intensive care unit patients: alarming observations. | ventilator-associated pneumonia (vap) is the most frequent nosocomial infection in patients receiving mechanical ventilation (mv) and contributes to a longer intensive care unit (icu) stay, duration of mv, and a high morbidity and mortality. | 2017 | 28681751 |
| titanium surfaces immobilized with the major antimicrobial fragment fk-16 of human cathelicidin ll-37 are potent against multiple antibiotic-resistant bacteria. | infections on implanted medical devices are a challenging problem, especially when bacteria form difficult-to-treat biofilms. antimicrobial peptides are considered to be a solution due to their potency against antibiotic-resistant superbugs. previously, the authors' laboratory demonstrated the prevention of staphylococcal biofilm formation in an animal catheter model by injecting merecidin (formerly known as 17biphe2), a peptide engineered based on the only human cathelicidin. this study documen ... | 2017 | 28675109 |
| the distribution of carbapenem- and colistin-resistance in gram-negative bacteria from the tamil nadu region in india. | the occurrence of carbapenem- and colistin-resistance among gram-negative bacteria is increasing worldwide. the aim of this study was to understand the distribution of carbapenem- and colistin-resistance in two areas in tamil nadu, india. | 2017 | 28671537 |
| extended-spectrum beta-lactamase producing gram negative bacteria in iran: a review. | the emergence and spread of extended spectrum β-lactamase (esbl)-producing gram- negative bacteria (gnb), particularly in enterobacteriaceae, acinetobacter baumannii, and pseudomonas aeruginosa, have increased all over the world. esbls are characterized by their ability to hydrolyze β-lactams, early cephalosporins, oxyimino-thiazolyl cephalosporins, and monobactams, but not cephamycins or carbapenems. the rate of nosocomial infections caused by esbl-producing gnb in asia pacific has increased an ... | 2017 | 28670639 |
| inhaled colistin monotherapy for respiratory tract infections in adults without cystic fibrosis: a systematic review and meta-analysis. | inhaled colistin is becoming increasingly popular against respiratory tract infections due to multidrug resistant (mdr) gram-negative bacteria since it may overcome the problems associated with iv administration. | 2017 | 28669836 |
| bacterial genus is a risk factor for major amputation in patients with diabetic foot. | to evaluate whether bacterial genus is a risk factor for major amputation in patients with diabetic foot and infected ulcer. | 2017 | 28658333 |
| risk factors for nosocomial infections in patients receiving extracorporeal membrane oxygenation supportive therapy. | the aim of this study was to analyze risk factors for nosocomial infection (ni) in patients receiving extracorporeal membrane oxygenation (ecmo) support. | 2017 | 28647277 |
| nonribosomal peptide synthetase biosynthetic clusters of eskape pathogens. | covering: up to 2017.natural products are important secondary metabolites produced by bacterial and fungal species that play important roles in cellular growth and signaling, nutrient acquisition, intra- and interspecies communication, and virulence. a subset of natural products is produced by nonribosomal peptide synthetases (nrpss), a family of large, modular enzymes that function in an assembly line fashion. because of the pharmaceutical activity of many nrps products, much effort has gone in ... | 2017 | 28642945 |
| the anticancer peptide tat-rasgap317-326 exerts broad antimicrobial activity. | antibiotic resistance has become a major health issue. nosocomial infections and the prevalence of resistant pathogenic bacterial strains are rising steadily. therefore, there is an urgent need to develop new classes of antibiotics effective on multi-resistant nosocomial pathogenic bacteria. we have previously shown that a cell-permeable peptide derived from the p120 ras gtpase-activating protein (rasgap), called tat-rasgap317-326, induces cancer cell death, inhibits metastatic progression, and ... | 2017 | 28638371 |
| evaluation of microorganisms causing ventilator-associated pneumonia in a pediatric intensive care unit. | the aim of this study was to identify microorganisms causing ventilator-associated pneumonia (vap) and also study the antibiotic resistance/susceptibility. | 2017 | 28638248 |
| role of positively charged residues on the polar and non-polar faces of amphipathic α-helical antimicrobial peptides on specificity and selectivity for gram-negative pathogens. | we have designed de novo and synthesized eight 26-residue all d-conformation amphipathic α-helical cationic antimicrobial peptides (amps), four with "specificity determinants" which provide specificity for prokaryotic cells over eukaryotic cells and four amps without specificity determinants. the eight amps contain six positively charged lys residues on the polar face in four different arrangements to understand the role of these residues have on antimicrobial activity against 14 acinetobacter b ... | 2017 | 28636788 |
| identification of 1-((2,4-dichlorophenethyl)amino)-3-phenoxypropan-2-ol, a novel antibacterial compound active against persisters of pseudomonas aeruginosa. | antibiotics typically fail to completely eradicate a bacterial population, leaving a small fraction of transiently antibiotic-tolerant persister cells intact. persisters are therefore seen to be a major cause of treatment failure and greatly contribute to the recalcitrant nature of chronic infections. the current study focused on pseudomonas aeruginosa, a gram-negative pathogen belonging to the notorious eskape group of pathogens (enterococcus faecium, staphylococcus aureus, klebsiella pneumonia ... | 2017 | 28630188 |
| in vitro activity of the siderophore cephalosporin, cefiderocol, against a recent collection of clinically relevant gram-negative bacilli from north america and europe, including carbapenem-nonsusceptible isolates (sidero-wt-2014 study). | cefiderocol (formerly s-649266) is an investigational siderophore cephalosporin. iron-depleted cation-adjusted mueller-hinton broth (id-camhb) was prepared according to the clinical and laboratory standards institute (clsi) protocol and used to perform broth microdilution testing of cefiderocol against a 2014-2015 collection of clinical isolates of gram-negative bacilli from north america (n = 4,239) and europe (n = 4,966). the concentrations of cefiderocol inhibiting 90% of isolates tested (mic ... | 2017 | 28630181 |
| efficacy of cefiderocol against carbapenem-resistant gram-negative bacilli in immunocompetent-rat respiratory tract infection models recreating human plasma pharmacokinetics. | cefiderocol (s-649266), a novel siderophore cephalosporin, shows potent activity against carbapenem-resistant gram-negative bacilli. in this study, we evaluated the efficacy of cefiderocol against carbapenem-resistant gram-negative bacilli (pseudomonas aeruginosa, acinetobacter baumannii, and klebsiella pneumoniae) in immunocompetent-rat respiratory tract infection models recreating plasma pharmacokinetics (pk) profiles in healthy human subjects. a total of 6 clinical isolates (1 cephalosporin-s ... | 2017 | 28630178 |
| patterns of antimicrobial resistance in intensive care unit patients: a study in vietnam. | antimicrobial resistance has emerged as a major concern in developing countries. the present study sought to define the pattern of antimicrobial resistance in icu patients with ventilator-associated pneumonia. | 2017 | 28619105 |
| patterns of multi-drug resistant bacteria at first culture from patients admitted to a third level university hospital in calabria from 2011 to 2014: implications for empirical therapy and infection control. | surveillance of antimicrobial drug resistance is fundamental to guide empirical treatment. however, the european antimicrobial resistance surveillance network provides a general picture, which might not be applicable to clinical settings that are excluded from this survey. we evaluated resistance patterns of eskape isolates over a four-year period in a third level university hospital in the province of catanzaro (southern italy). in this retrospective study, we evaluated the frequency of eskape ... | 2017 | 28603227 |
| the tnf-α of mast cells induces pro-inflammatory responses during infection with acinetobacter baumannii. | mast cells serve important roles as sentinels against bacterial infection by secreting mediators stored in granules. much of their effectiveness depends upon recruiting and/or modulating other immune cells. the location of mast cells implies that they recognize pathogens invading tissues or mucosal tissues. acinetobacter baumannii is a gram-negative bacterium that is considered an emerging nosocomial pathogen and causes a wide range of infections associated with high morbidity and mortality. to ... | 2017 | 28595750 |
| antimicrobial activity, toxicity and anti-inflammatory potential of methanolic extracts of four ethnomedicinal plant species from punjab, pakistan. | the plant species aristolochia indica (ai), melilotus indicus (mi), tribulus terrestris (tt) and cuscuta pedicellata (cp) are widely used in folk medicine in the villages around chowk azam, south punjab, pakistan. the aim of this study was to evaluate the antioxidant activity, phytochemical composition, and the antibacterial, antifungal, cytotoxic and anti-inflammatory potential of the four medicinal plants listed above. for cp stem, this study represents (to the best of our knowledge) the first ... | 2017 | 28595608 |
| prevalence of biofilm producing aerobic bacterial isolates in burn wound infections at a tertiary care hospital in northern india. | burn wounds frequently get infected due to a break in skin integrity and prolonged hospitalization. microbial flora originating from the patient's own flora colonize and infect the burn wounds. bacterial biofilms in particular are postulated as the culprit for the development of non-healing burn wounds by inducing chronic inflammation in these patients. in the present study, 190 wound isolates obtained from patients admitted to the burn ward at the pt. b.d. sharma pgims, rohtak, were evaluated f ... | 2017 | 28592933 |
| a genoproteomic approach to detect peptide markers of bacterial respiratory pathogens. | rapid identification of respiratory pathogens may facilitate targeted antimicrobial therapy. direct identification of bacteria in bronchoalveolar lavage (bal) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is confounded by interfering substances. we describe a method to identify unique peptide markers of 5 gram-negative bacteria by liquid chromatography-tandem mass spectrometry (lc-ms/ms) for direct pathogen identification in bal. | 2017 | 28588123 |
| evaluation of the in vitro antimicrobial activity of selected saudi scorpion venoms tested against multidrug-resistant micro-organisms. | scorpion venoms are a rich source of bioactive peptides with promising clinical value that may lead to the discovery and development of new drugs. the present study was designed to evaluate the in vitro antimicrobial activities of the venoms extracted from three medically important saudi scorpions (androctonus crassicauda, androctonus bicolor and leiurus quinquestriatus). | 2017 | 28587870 |
| bacteria from animals as a pool of antimicrobial resistance genes. | antimicrobial agents are used in both veterinary and human medicine. the intensive use of antimicrobials in animals may promote the fixation of antimicrobial resistance genes in bacteria, which may be zoonotic or capable to transfer these genes to human-adapted pathogens or to human gut microbiota via direct contact, food or the environment. this review summarizes the current knowledge of the use of antimicrobial agents in animal health and explores the role of bacteria from animals as a pool of ... | 2017 | 28587316 |
| properties of probiotics kocuria sm1 and rhodococcus sm2 isolated from fish guts. | this study characterized probiotics kocuria sm1 and rhodococcus sm2, which were recovered from the intestinal microbiota of rainbow trout (oncorhynchus mykiss, walbaum). the cultures were gram-positive, non-motile, catalase-positive and oxidase-negative cocci or rods. cell multiplication of sm1 and sm2 was observed at 4-37 °c (45 °c for sm1), in 0-20% (w/v) nacl and at ph 2-11. the viability was not affected when exposed to pepsin at ph 2.0 and 3.0, and pancreatin at ph 8.0. neither isolates wer ... | 2017 | 28585158 |
| transmission of health care-associated infections from roommates and prior room occupants: a systematic review. | pathogens that cause health care-associated infections (hais) are known to survive on surfaces and equipment in health care environments despite routine cleaning. as a result, the infection status of prior room occupants and roommates may play a role in hai transmission. we performed a systematic review of the literature evaluating the association between patients' exposure to infected/colonized hospital roommates or prior room occupants and their risk of infection/colonization with the same org ... | 2017 | 28579835 |
| design of live attenuated bacterial vaccines based on d-glutamate auxotrophy. | vaccine development is a priority for global health due to the growing multidrug resistance in bacteria. d-glutamate synthesis is essential for bacterial cell wall formation. here we present a strategy for generating effective bacterial whole-cell vaccines auxotrophic for d-glutamate. we apply this strategy to generate d-glutamate auxotrophic vaccines for three major pathogens, acinetobacter baumannii, pseudomonas aeruginosa and staphylococcus aureus. these bacterial vaccines show virulence atte ... | 2017 | 28548079 |
| [clinical and microbiological study of catheter-associated urinary tract infections in internal medicine services of a venezuelan university hospital]. | to determine the clinical and microbiological characteristics of catheter-associated urinary tract infections (ca-uti) in patients admitted to the internal medicine services of the hospital universitario de los andes (hula), mérida, venezuela and to establish the clonal distribution of multi-resistant enterobacteriaceae that produce this infection. | 2017 | 28538846 |
| celecoxib enhances the efficacy of low-dose antibiotic treatment against polymicrobial sepsis in mice and clinical isolates of eskape pathogens. | treatment of multidrug resistant bacterial infections has been a great challenge globally. previous studies including our study have highlighted the use of celecoxib, a non-steroidal anti-inflammatory drug in combination with antibiotic has decreased the minimal inhibitory concentration to limit staphylococcus aureus infection. however, the efficacy of this combinatorial treatment against various pathogenic bacteria is not determined. therefore, we have evaluated the potential use of celecoxib i ... | 2017 | 28533769 |
| [efficacy and safety of colistimethate sodium in critical patients: an in vitro study by using of monte carlo simulation]. | to evaluate the efficacy and safety of colistimethate sodium (cms) for the treatment of critical patients infected by pan-drug resistant acinetobacter baumannii (pdr-ab) or pan-drug resistant pseudomonas aeruginosa (pdr-pa). | 2017 | 28524024 |
| colonization of long term care facility patients with mdr-gram-negatives during an acinetobacter baumannii outbreak. | we aimed to determine the prevalence of colonization by multidrug-resistant gram-negative bacteria including esbl-producing enterobacteriaceae, carbapenem-resistant enterobacteriaceae, pseudomonas aeruginosa and acinetobacter baumannii at two wards caring long term for patients with disorder of consciousness at the geriatric health centers graz, austria. during our study we detected two a. baumannii outbreaks. | 2017 | 28515905 |
| biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype. | bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (mdros). nevertheless, a quantitative correlation between biofilm production and the profile of antimicrobial drug resistance in delayed wound healing remains to be determined. microbial identification, antibiotic susceptibility and biofilm production were assessed in 135 clinical isolates from 87 patients. gram-negative bacteria were ... | 2017 | 28513576 |
| bactericidal activity of herbal volatile oil extracts against multidrug-resistant acinetobacter baumannii. | the aim of the study is to investigate the antibacterial activity of 10 volatile oils extracted from medicinal plants, including galangal (alpinia galanga linn.), ginger (zingiber officinale), plai (zingiber cassumunar roxb.), lime (citrus aurantifolia), kaffir lime (citrus hystrix dc.), sweet basil (ocimum basilicum linn.), tree basil (ocimum gratissimum), lemongrass (cymbopogon citratus dc.), clove (syzygium aromaticum), and cinnamon (cinnamomum verum) against four standard strains of staphylo ... | 2017 | 28512603 |
| severely infected pneumoceles of the frontal sinus in patients with mental retardation and brain atrophy treated by endoscopic sinus surgery. | we herein present three cases of abnormally expanded frontal sinuses (pneumoceles) with severe infection in patients with mental retardation and brain atrophy. two patients previously underwent laryngotracheal separation surgery, and bacteriological examinations of purulent nasal discharge revealed infections caused by drug-resistant bacteria such as pseudomonas aeruginosa and acinetobacter baumannii. as conservative medical treatments were ineffective, all three patients were treated by compute ... | 2017 | 28511889 |
| multicenter evaluation of the rapidec® carba np test for rapid screening of carbapenemase-producing enterobacteriaceae and gram-negative nonfermenters from clinical specimens. | the rapid diagnosis of carbapenemase-producing (cp) bacteria is essential for the management of therapy and infection control. in this study, rapidec® carba np (rcnp) was evaluated for the rapid screening of cp enterobacteriaceae, acinetobacter baumannii complex, and pseudomonas aeruginosa from clinical specimens collected at five italian hospitals. firstly, each site tested 20 well-characterized strains in a blinded fashion. secondly, each center prospectively tested 25 isolates from blood cult ... | 2017 | 28502395 |
| punica granatum peel extracts: hplc fractionation and lc ms analysis to quest compounds having activity against multidrug resistant bacteria. | medicinal plants are rich source of traditional herbal medicine around the globe. most of the plant's therapeutic properties are due to the presence of secondary bioactive compounds. | 2017 | 28468660 |
| differences in antimicrobial consumption, prescribing and isolation rate of multidrug resistant klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumannii on surgical and medical wards. | in order to provide guidance data for clinically rational use of an antibiotics consuption, prescribing and prevalence of multidrug resistant (mdr) klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumannii were monitored on the surgical (s) and medical (m) wards of the university hospital center "dr. dragisa misovic-dedinje" (belgrade, serbia), in the study period from 2012 to 2015. appropriateness of antimicrobial use was evaluated using the global-prevalence survey method desig ... | 2017 | 28467437 |
| simple and fast detection of resistance to antibiotic inhibitors of protein synthesis in gram-negative pathogens through evaluation of mitomycin c-induced cell elongation. | increasing the resistance of gram-negative pathogens to antibiotics that inhibit protein synthesis is of great concern. in life-threatening situations, an early detection of antibiotic resistance may improve patient outcome. a rapid assay for the identification of antibiotic resistance to gentamicin, tobramycin, and tigecycline has been designed and tested in clinical strains of acinetobacter baumannii, pseudomonas aeruginosa, and the enterobacteriaceae escherichia coli and klebsiella pneumoniae ... | 2017 | 28467172 |
| pitfalls associated with evaluating enzymatic quorum quenching activity: the case of moml and its effect on pseudomonas aeruginosa and acinetobacter baumannii biofilms. | the enzymatic degradation of quorums sensing (qs) molecules (called quorum quenching, qq) has been considered as a promising anti-virulence therapy to treat biofilm-related infections and combat antibiotic resistance. the recently-discovered qq enzyme moml has been reported to efficiently degrade different n-acyl homoserine lactones (ahls) of various gram-negative pathogens. here we investigated the effect of moml on biofilms formed by two important nosocomial pathogens, pseudomonas aeruginosa a ... | 2017 | 28462048 |
| thiolated aunp probes and multiplex pcr for molecular detection of staphylococcus epidermidis. | the emergence of nanotechnology in biology helps to apply the gold nanoparticle probes for fast and accurate identification of pathogens compared to the time-consuming and non-precise phenotypic methods. in this study, two molecular methods have been established for the accurate identification of staphylococcus epidermidis from other coagulase-negative staphylococci. multiplex pcr was performed using designed primers for gmk2 and pta housekeeping genes, and sesb specific gene of s. epidermidis. ... | 2017 | 28461258 |
| the use of bloodstream infection mortality to measure the impact of antimicrobial stewardship interventions: assessing the evidence. | this review sets out to evaluate the current evidence on the impact of inappropriate therapy on bloodstream infections (bsi) and associated mortality. based on the premise that better prescribing practices should result in better patient outcomes, bsi mortality may be a useful metric to evaluate antimicrobial stewardship (ams) interventions. a systematic search was performed in key medical databases to identify papers published in english between 2005 and 2015 that examined the association betwe ... | 2017 | 28458799 |
| efficacy and toxicity of high-dose nebulized colistin for critically ill surgical patients with ventilator-associated pneumonia caused by multidrug-resistant acinetobacter baumannii. | few studies have compared nebulized and intravenous (iv) colistin for multidrug-resistant acinetobacter baumannii and pseudomonas aeruginosa pneumonia. this study compared the nephrotoxicity and clinical outcomes for these two delivery routes. | 2017 | 28458172 |
| copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: antimicrobial and biophysical properties. | a series of four thiosemicarbazones from 6-nitropiperonal along with the corresponding copper complexes were synthesized. the biophysical characteristics of the complexes were investigated by the binding to dna and human serum albumin. the binding to dna is moderate; the binding constants run from (0.49-7.50)×10(4)m(-1). in relation to hsa, the complexes interact strongly with binding constants on the order of 10(5)m(-1). the complexes also display antioxidant behavior as determined by the abili ... | 2017 | 28448954 |
| evaluation of six phenotypic methods for the detection of carbapenemases in gram-negative bacteria with characterized resistance mechanisms. | we compared the performance of the modified hodge test (mht), triton hodge test (tht), carba np test (cnpt), simplified carba np test (cnpt-direct), blue-carba np test (bct), and carbapenem inactivation method (cim) for rapid and accurate carbapenemase detection. | 2017 | 28445009 |
| epidemiological, physiological, and molecular characteristics of a brazilian collection of carbapenem-resistant acinetobacter baumannii and pseudomonas aeruginosa. | nonfermenting gram-negative bacteria such as pseudomonas aeruginosa and acinetobacter baumannii are widespread in the environment and are increasingly associated with nosocomial infections, often associated with multidrug-resistance phenotypes. this study aimed to evaluate epidemiological, physiological, and molecular characteristics of carbapenem resistance in p. aeruginosa and a. baumannii. in total, 63 nonreplicated strains (44 a. baumannii and 19 p. aeruginosa) were isolated from hospitalize ... | 2017 | 28437232 |
| resistance profiles and risk factors of resistant microorganisms in bacteraemia of abdominal origin. | the presence of resistant microorganisms is a major cause of failure in initial empirical antimicrobial therapy. the objectives of this study are to determine the resistance profile of microorganisms that cause bacteraemia of abdominal origin and to identify whether the previous use of antibiotics and the place of acquisition of bacteraemia are risk factors associated with the presence of resistant organisms. | 2017 | 28434558 |
| trimethyl chitosan-capped silver nanoparticles with positive surface charge: their catalytic activity and antibacterial spectrum including multidrug-resistant strains of acinetobacter baumannii. | we report a facile route for the green synthesis of trimethyl chitosan nitrate-capped silver nanoparticles (tmcn-agnps) with positive surface charge. in this synthesis, silver nitrate, glucose, and trimethyl chitosan nitrate (tmcn) were used as silver precursor, reducing agent, and stabilizer, respectively. the reaction was carried out in a stirred basic aqueous medium at room temperature without the use of energy-consuming or expensive equipment. we investigated the effects of the concentration ... | 2017 | 28411476 |
| evaluation of intraventricular colistin utilization: a case series. | multi-drug resistant organisms (mdros) are an increasing concern in health systems. pathogens such as pseudomonas aeruginosa, acinetobacter baumanii, and carbapenamase-producing enterobacteriaceae hold highest mortality rates especially when the central nervous system is involved. when mdros are cultured treatment options are limited and reliance on medications such as colistin is becoming more prevalent. penetration of these therapies into the central nervous system is concerning therefore loca ... | 2017 | 28410511 |
| synthesis and characterization of tetrahydropyran-based bacterial topoisomerase inhibitors with antibacterial activity against gram-negative bacteria. | there is an urgent unmet medical need for novel antibiotics that are effective against a broad range of bacterial species, especially multidrug resistant ones. tetrahydropyran-based inhibitors of bacterial type ii topoisomerases (dna gyrase and topoisomerase iv) display potent activity against gram-positive pathogens and no target-mediated cross-resistance with fluoroquinolones. we report our research efforts aimed at expanding the antibacterial spectrum of this class of molecules toward difficu ... | 2017 | 28406300 |
| resistance among gram-negative eskape pathogens isolated from hospitalized patients with intra-abdominal and urinary tract infections in latin american countries: smart 2013-2015. | gram-negative eskape pathogens (klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa, and enterobacter species) are important etiologic agents of nosocomial infection that are frequently resistant to broad-spectrum antimicrobial agents. gram-negative eskape pathogens were collected from hospitalized patients in 11 latin american countries from 2013 to 2015 as part of the study for monitoring antimicrobial resistance trends (smart) global surveillance program. in total, 2113 iso ... | 2017 | 28399424 |
| in vitro activity of cefepime/zidebactam (wck 5222) against gram-negative bacteria. | diazabicyclooctanes (dbos) inhibit class a, class c and some class d β-lactamases. a few also bind pbp2, conferring direct antibacterial activity and a β-lactamase-independent 'enhancer' effect, potentiating β-lactams targeting pbp3. we tested a novel dbo, zidebactam, combined with cefepime. | 2017 | 28158732 |
| epidemiology and trends in the antibiotic susceptibilities of gram-negative bacilli isolated from patients with intra-abdominal infections in the asia-pacific region, 2010-2013. | this study was conducted to investigate the epidemiology and antimicrobial susceptibility patterns of gram-negative bacilli (gnb) isolated from intra-abdominal infections (iais) in the asia-pacific region (apr) from 2010-2013. a total of 17 350 isolates were collected from 54 centres in 13 countries in the apr. the three most commonly isolated gnb were escherichia coli (46.1%), klebsiella pneumoniae (19.3%) and pseudomonas aeruginosa (9.8%). overall, the rates of extended-spectrum β-lactamase (e ... | 2017 | 28435019 |
| evaluation of bacterial pathogen diversity, abundance and health risks in urban recreational water by amplicon next-generation sequencing and quantitative pcr. | the microbial quality of urban recreational water is of great concern to public health. the monitoring of indicator organisms and several pathogens alone is not sufficient to accurately and comprehensively identify microbial risks. to assess the levels of bacterial pathogens and health risks in urban recreational water, we analyzed pathogen diversity and quantified four pathogens in 46 water samples collected from waterbodies in beijing olympic forest park in one year. the pathogen diversity rev ... | 2017 | 28647233 |
| a topical hydrogel with deferiprone and gallium-protoporphyrin targets bacterial iron metabolism and has antibiofilm activity. | many infectious diseases are associated with multidrug-resistant (mdr) bacteria residing in biofilms that require high antibiotic concentrations. while oral drug delivery is frequently ineffective, topical treatments have the potential to deliver higher drug concentrations to the infection site while reducing systemic side effects. this study determined the antibiofilm activity of a surgical wound gel loaded with the iron chelator deferiprone (def) and the heme analogue gallium-protoporphyrin (g ... | 2017 | 28396543 |
| micromethods for isolation and structural characterization of lipid a, and polysaccharide regions of bacterial lipopolysaccharides. | lipopolysaccharides (lps) are major components of the external membrane of most gram-negative bacteria, providing them with an effective permeability barrier. they are essentially composed of a hydrophilic polysaccharide region (ps) linked to a hydrophobic one, termed lipid a. the lps polysaccharide moiety is divided into the core oligosaccharide (os) and o-chain repetitive elements. depending on their individual variable fine structures, lps may be potent immunomodulators. the lipid a structure ... | 2017 | 28478567 |
| in vitro selection and identification of potential probiotics isolated from the gastrointestinal tract of nile tilapia, oreochromis niloticus. | fish gut bacteria can be used as probiotics for aquaculture. the aim of this study is to screen and identify beneficial probiotic bacteria from the gut of nile tilapia, oreochromis niloticus. nine out of one hundred thirty-five isolates were non-pathogenic through intraperitoneal injection and had antibacterial activities with at least a strain from the five isolated fish pathogens, aeromonas sobria, aeromonas hydrophila, pseudomonas aeruginosa, pseudomonas putida, and staphylococcus aureus. fur ... | 2017 | 28819794 |
| antimicrobial property of lemongrass (cymbopogon citratus) oil against pathogenic bacteria isolated from pet turtles. | the usage of essential oils as antimicrobial agents is gaining attention. besides, pet turtles were known to harbor a range of pathogenic bacteria while the turtle keeping is a growing trend worldwide.the current study examined the antimicrobial activity of lemon grass oil (lgo) against seven species of gram negative bacteria namely; aeromonas hydrophila, a. caviae, citrobacter freundii, salmonella enterica, edwardsiella tarda, pseudomonas aeruginosa, and proteus mirabilis isolated from three po ... | 2017 | 28747972 |
| assessment of cultivable oral bacterial flora from important venomous snakes of india and their antibiotic susceptibilities. | snakebite is a common, frequently devastating, occupational, socio-economic hazard, and it has a great impact on the rural population of india. snakebite is a major cause of the human morbidity and mortality since ancient times, as it not only affects the victim by systemic envenomation but also by wound infections originating from deadly pathogenic microorganisms from the oral cavity of the offending snake. the pathogens from the oral cavity of the snake tend to initiate an infection, resulting ... | 2017 | 28733908 |
| leaf extracts of mangifera indica l. inhibit quorum sensing - regulated production of virulence factors and biofilm in test bacteria. | quorum sensing (qs) is a global gene regulatory mechanism in bacteria for various traits including virulence factors. disabling qs system with anti-infective agent is considered as a potential strategy to prevent bacterial infection. mangifera indica l. (mango) has been shown to possess various biological activities including anti-qs. this study investigates the efficacy of leaf extracts on qs-regulated virulence factors and biofilm formation in gram negative pathogens. mango leaf (ml) extract w ... | 2017 | 28484444 |
| antagonistic properties of some halophilic thermoactinomycetes isolated from superficial sediment of a solar saltern and production of cyclic antimicrobial peptides by the novel isolate paludifilum halophilum. | this study has focused on the isolation of twenty-three halophilic actinomycetes from two ponds of different salinity and the evaluation of their ability to exert an antimicrobial activity against both their competitors and several other pathogens. from the 23 isolates, 18 strains showed antagonistic activity, while 19 showed activities against one or more of the seven pathogen strains tested. six strains exhibited consistent antibacterial activity against gram-negative and gram-positive pathoge ... | 2017 | 28819625 |
| use of chimeric type iv secretion systems to define contributions of outer membrane subassemblies for contact-dependent translocation. | recent studies have shown that conjugation systems of gram-negative bacteria are composed of distinct inner and outer membrane core complexes (imcs and omccs, respectively). here, we characterized the omcc by focusing first on a cap domain that forms a channel across the outer membrane. strikingly, the omcc caps of the escherichia coli pkm101 tra and agrobacterium tumefaciens virb/vird4 systems are completely dispensable for substrate transfer, but required for formation of conjugative pili. the ... | 2017 | 28452085 |
| analysis of antimicrobial and immunomodulatory substances produced by heterofermentative lactobacillus reuteri. | antimicrobial and immunomodulatory potential of various lactobacillus reuteri strains is closely connected to their metabolite production profile under given cultivation conditions. we determined the in vitro production of antimicrobial substances such as organic acids, ethanol, and reuterin by four strains of l. reuteri (l. reuteri e, l. reuteri ko5, l. reuteri ccm 3625, and l. reuteri atcc 55730). all studied l. reuteri strains showed the ability to produce lactic acid, acetic acid, and ethano ... | 2017 | 28401403 |
| antimicrobial activity and chemical composition of brunfelsia uniflora flower oleoresin extracted by supercritical carbon dioxide. | brunfelsia genus is traditionally utilized in popular medicine due to its antibacterial and antifungal properties to name but a few. however, studies on the antimicrobial activity of brunfelsia uniflora flower oleoresin have not been found yet. this study aimed to evaluate the chemical composition and antimicrobial activity of b. uniflora flower oleoresin obtained by supercritical carbon dioxide. oleoresin from the plant dried flowers was obtained by carbon dioxide, and the chemical composition ... | 2017 | 28407186 |
| green synthesis and characterization of gold and silver nanoparticles using mussaenda glabrata leaf extract and their environmental applications to dye degradation. | plant-derived nanomaterials opened a green approach in solving the current environment issues. present study focused on rapid microwave-assisted synthesis and applications of gold and silver nanoparticles mediated by aqueous leaf extract of mussaenda glabrata. the synthesized nanoparticles were characterized by uv-vis, ft-ir, powder xrd, energy-dispersive x-ray spectroscopy (edx), transmission electron (tem), and atomic force microscopic techniques (afm). fcc crystal structure of both nanopartic ... | 2017 | 28589274 |
| edible wild plant heracleum pyrenaicum subsp. orsinii as a potential new source of bioactive essential oils. | many heracleum l. taxa (apiaceae) are used as food and spices, and in traditional medicine. in this work, the chemical composition of heracleum pyrenaicum subsp. orsinii (guss.) f. pedrotti and pignatti root, leaf and fruit essential oils, their antimicrobial activity and cytotoxic effect on malignant and normal cells were investigated for the first time. the composition of the oils was analyzed by gc and gc-ms. monoterpenes prevailed in the root oil, with β-pinene (38.6%) being dominant, while ... | 2017 | 28740275 |
| variants of lipopeptides and glycolipids produced by bacillus amyloliquefaciens and pseudomonas aeruginosa cultured in different carbon substrates. | the quantitative and qualitative effect of water immiscible and miscible carbon-rich substrates on the production of biosurfactants, surfactin and rhamnolipids, by bacillus amyloliquefaciens st34 and pseudomonas aeruginosa st5, respectively, was analysed. a small-scale high throughput 96 deep-well micro-culture method was utilised to cultivate the two strains in mineral salt medium (msm) supplemented with the water miscible (glucose, glycerol, fructose and sucrose) and water immiscible carbon so ... | 2017 | 28571307 |
| characterisation and antimicrobial activity of biosurfactant extracts produced by bacillus amyloliquefaciens and pseudomonas aeruginosa isolated from a wastewater treatment plant. | biosurfactants are unique secondary metabolites, synthesised non-ribosomally by certain bacteria, fungi and yeast, with their most promising applications as antimicrobial agents and surfactants in the medical and food industries. naturally produced glycolipids and lipopeptides are found as a mixture of congeners, which increases their antimicrobial potency. sensitive analysis techniques, such as liquid chromatography coupled to mass spectrometry, enable the fingerprinting of different biosurfact ... | 2017 | 28571306 |
| functional silver nanocomposites as broad-spectrum antimicrobial and biofilm-disrupting agents. | biofilms' tolerance has become a serious clinical concern due to their formidable resistance to conventional antibiotics and prevalent virulence. therefore, there is an urgent need to develop alternative antimicrobial agents to eradicate biofilms but avoid using antibiotics. herein, we successfully developed polymer functional silver nanocomposites by reduction of silver nitrate in the presence of a biocompatible carbohydrate polymer and a membrane-disrupting cationic polymer. the nanocomposites ... | 2017 | 28481506 |
| phenolic acids and flavonoids of peanut by-products: antioxidant capacity and antimicrobial effects. | peanut skin (ps) and meal from dry-blanched peanuts (mdbp) were evaluated as sources of phenolic compounds. ps rendered the highest total phenolic content, antioxidant capacity towards abts radical cation, dpph and hydroxyl radicals as well as reducing power. phenolic acids were present in ps and mdbp whereas proanthocyanidins and monomeric flavonoids were found only in ps as identified by hplc-dad-esi-ms(n). procyanidin-rich extracts prevented oxidation in non-irradiated and gamma-irradiated fi ... | 2017 | 28764032 |
| sinonasal t2r-mediated nitric oxide production in response to bacillus cereus. | upper airway epithelial cells produce bactericidal nitric oxide (no) in response to both gram-positive and gram-negative bacteria. our previous work demonstrated that t2r38, a bitter taste receptor (t2r) expressed in airway epithelium, produces no in response to quorum-sensing molecules secreted by pseudomonas aeruginosa. we also demonstrated that staphylococci products elicit an no response when using a t2r-independent pathway. when screening additional human pathogens for epithelial t2r activa ... | 2017 | 28716170 |
| an enhancement of antimicrobial efficacy of biogenic and ceftriaxone-conjugated silver nanoparticles: green approach. | of the various methods explored for the synthesis of nanoparticles, biogenesis of silver nanoparticles (agnps) received great attention due to their versatile properties. in this report, daucus carota extract was used for the synthesis of agnps and ceftriaxone was conjugated with agnps to enhance their antimicrobial efficacy. the conjugated and unconjugated agnps were characterized by adopting uv-vis spectroscopy, ftir, afm, dls, and tem, which revealed the spr peak at 420 nm and spherical shape ... | 2017 | 28600792 |
| identification of microorganisms isolated from counterfeit and unapproved decorative contact lenses. | all contact lenses (corrective/noncorrective) are considered class ii or class iii medical devices under the federal food, drug, and cosmetic act, which also states that contact lenses can only be obtained with a prescription. the forensic chemistry center of the us food & drug administration has examined over 300 decorative, noncorrective contact lenses obtained without a prescription. our observations indicate that 60% of the counterfeit lenses and 27% of the unapproved lenses examined were po ... | 2017 | 28542816 |
| cyclic diarylheptanoids from corylus avellana green leafy covers: determination of their absolute configurations and evaluation of their antioxidant and antimicrobial activities. | the methanol extract of the leafy covers of corylus avellana, source of the italian pgi (protected geographical indication) product "nocciola di giffoni", afforded two new cyclic diarylheptanoids, giffonins t and u (2 and 3), along with two known cyclic diarylheptanoids, a quinic acid, flavonoid-, and citric acid derivatives. the structures of giffonins t and u were determined as highly hydroxylated cyclic diarylheptanoids by 1d and 2d nmr experiments. their relative configurations were assigned ... | 2017 | 28520428 |
| antibacterial and antioxidative activity of o-amine functionalized chitosan. | cinnamaldehyde was immobilized to o-amine functionalized chitosan via a coupling reaction. fourier transform infrared spectroscopy confirmed n-cinnamyl substitution. wetting analyses demonstrate more hydrophobicity in the n-cinnamyl substituted o-amine functionalized chitosan compared to chitosan or unsubstituted o-amine functionalized chitosan. thermal gravimetric analysis and differential scanning calorimetry demonstrates that the prepared n-cinnamyl substituted o-amine functionalized chitosan ... | 2017 | 28504167 |
| green synthesis, characterisation and bioactivity of plant-mediated silver nanoparticles using decalepis hamiltonii root extract. | consistent search of plants for green synthesis of silver nanoparticles (snps) is an important arena in nanomedicine. this study focuses on synthesis of snps using bioreduction of silver nitrate (agno3) by aqueous root extract of decalepis hamiltonii. the biosynthesis of snps was monitored by uv-vis analysis at absorbance maxima 432 nm. the fluorescence emission spectra of snps illustrated the broad emission peak 450-483 nm at different excitation wavelengths. the surface characteristics were st ... | 2017 | 28476981 |
| self assembled snowball-like hybrid nanostructures comprising viburnum opulus l. extract and metal ions for antimicrobial and catalytic applications. | herein, we report the production of novel organic-inorganic nanobio-catalytic and antimicrobial agents called "nanosnowball" (nsbs) with a rational design and elucidate the increase in the catalytic and antimicrobial activities. the nsbs resemble to guelder rose were formed of the extract of viburnum opulus (vo) as the organic component and copper (ii) ions (cu(2+)) as the inorganic component. the effects of the vo extract and cu(2+) concentrations on the morphology of nsbs were systematically e ... | 2017 | 28465062 |
| production and characterization of curcumin microcrystals and evaluation of the antimicrobial and sensory aspects in minimally processed carrots. | nontoxic conserving agents are in demand by the food industry due to consumers concern about synthetic conservatives, especially in minimally processed food. the antimicrobial activity of curcumin, a natural phenolic compound, has been extensively investigated but hydrophobicity is an issue when applying curcumin to foodstuff. the objective of this work was to evaluate curcumin microcrystals as an antimicrobial agent in minimally processed carrots. the antimicrobial activity of curcumin microcry ... | 2017 | 28406506 |
| molecular characterization and functional analysis of the hepcidin gene from roughskin sculpin (trachidermus fasciatus). | hepcidin is a kind of cysteine-rich antimicrobial peptide that plays a vital role in host innate immune activity and iron regulation. here, we report the molecular characterization and functional analysis of a novel hamp1 hepcidin isoforms tf-hep from roughskin sculpin, trachidermus fasciatus. a cdna fragment of 988 bp with an orf of 273 bp was obtained. the coding sequence encodes for a signal peptide of 24 amino acids coupled with a prodomain of 40 amino acids and a mature peptide of 26 amino ... | 2017 | 28743631 |
| growth inhibition and antibiofilm potential of ag nanoparticles coated with lectin, an arthropod immune molecule. | lectins from the haemolymph of arthropods, including crustaceans, are molecules potentially involved in the immune recognition and phagocytosis. here, lectin was purified from the haemolymph of blue swimmer crab portunus pelagicus, using mannose-coupled sepharose cl-4b affinity column chromatography. in sds-page analysis, lectin showed a molecular mass of approximately 155kda. the synthesis of lectin-coated silver nanoparticles (lectin-coated agnps) was confirmed by uv-vis spectroscopy, xrd, fti ... | 2017 | 28441606 |
| enhancing antidiabetic and antimicrobial performance of ocimum basilicum, and ocimum sanctum (l.) using silver nanoparticles. | the role of silver nanoparticles (agnps) is an attractive proposition for advancing modern diabetes therapies and applied science. stable agnps with a size range of 3-25 nm were synthesized using aqueous leaf extracts from ocimum basilicum, ocimum sanctum, and in combination. the concentration of the extracts facilitated the reduction of silver nitrate that led to the rapid formation of agnps at room temperature, indicating a higher reaction rate as opposed to harsh chemical methods, and high co ... | 2017 | 28855825 |
| environmental monitoring and assessment of antibacterial metabolite producing actinobacteria screened from marine sediments in south coastal regions of karnataka, india. | assessment of the therapeutic potential of secondary metabolite producing microorganisms from the marine coastal areas imparts scope and application in the field of environmental monitoring. the present study aims to screen metabolites with antibacterial potential from actionbacteria associated with marine sediments collected from south coastal regions of karnataka, india. the actinobacteria were isolated and characterized from marine sediments by standard protocol. the metabolites were extracte ... | 2017 | 28534309 |
| progress in definition, prevention and treatment of fungal infections in cystic fibrosis. | cystic fibrosis (cf) is a chronic lethal multi-system condition; however, most of the morbidity and mortality is dependent on the status of the respiratory system. progressive respiratory decline is mediated by chronic infection and inflammation, punctuated by important acute events known as pulmonary exacerbations which can lead to accelerated decline. the main bacterial species causing infections include pseudomonas aeruginosa, staphylococcus aureus, haemophilus influenzae and achromobacter xy ... | 2017 | 28762125 |
| air pollution exposure is associated with mrsa acquisition in young u.s. children with cystic fibrosis. | the role of air pollution in increasing susceptibility to respiratory tract infections in the cystic fibrosis (cf) population has not been well described. we recently demonstrated that chronic pm2.5 exposure is associated with an increased risk of initial pseudomonas aeruginosa acquisition in young children with cf. the purpose of this study was to determine whether pm2.5 exposure is a risk factor for acquisition of other respiratory pathogens in young children with cf. | 2017 | 28750627 |
| seasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis. | seasonal variations are often observed for respiratory tract infections; however, limited information is available regarding seasonal patterns of acquisition of common cystic fibrosis (cf)-related respiratory pathogens. we previously reported differential seasonal acquisition of pseudomonas aeruginosa in young children with cf and no such variation for methicillin-susceptible staphylococcus aureus acquisition. the purpose of this study was to describe and compare the seasonal incidence of acquis ... | 2017 | 28599639 |
| hypertonic saline as a useful tool for sputum induction and pathogen detection in cystic fibrosis. | the aim of this study was to compare the qualitative and semi-quantitative detection of pathogens in the airway secretions of patients with cystic fibrosis (cf) and the sputum induction capacity before and after inhalation of 7% hypertonic saline solution (hss). | 2017 | 28455785 |
| diagnosis of biofilm infections in cystic fibrosis patients. | chronic pseudomonas aeruginosa biofilm lung infection in cystic fibrosis patients is the best described biofilm infection in medicine. the initial focus can be the paranasal sinuses and then follows repeated colonization and infection of the lungs by aspiration. the matrix of the biofilms is dominated by alginate and the pathogenesis of tissue damage is immune complex-mediated chronic inflammation dominated by polymorphonuclear leukocytes and their products (dna, oxygen radicals and proteases). ... | 2017 | 28407432 |
| widespread fosfomycin resistance in gram-negative bacteria attributable to the chromosomal fosa gene. | fosfomycin is a decades-old antibiotic which is being revisited because of its perceived activity against many extensively drug-resistant gram-negative pathogens. fosa proteins are mn(2+) and k(+)-dependent glutathione s-transferases which confer fosfomycin resistance in gram-negative bacteria by conjugation of glutathione to the antibiotic. plasmid-borne fosa variants have been reported in fosfomycin-resistant escherichia coli strains. however, the prevalence and distribution of fosa in other g ... | 2017 | 28851843 |
| comparison of a new matrix-assisted laser desorption/ionization time-of-flight mass spectrometry platform, asta microidsys, with bruker biotyper for species identification. | matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, with its accuracy and speed, is widely used for bacterial identification. the asta microidsys system (asta, korea) was recently developed for species identification. we compared its performance with that of bruker biotyper (bruker daltonics, germany). microbes were recovered from sputum, urine, and pus samples from patients admitted to a tertiary care hospital in korea from january to april 2016. matrix solution (α-cya ... | 2017 | 28840993 |
| reversibility of covalent, broad-spectrum serine β-lactamase inhibition by the diazabicyclooctenone etx2514. | etx2514 is a non-β-lactam serine β-lactamase inhibitor in clinical development that has greater potency and broader spectrum of β-lactamase inhibition than the related diazabicyclooctanone avibactam. despite opening of its cyclic urea ring upon acylation, avibactam can recyclize and dissociate intact from certain β-lactamases. we investigated reversibility of etx2514 acylation of 10 serine β-lactamases representing ambler classes a, c, and d. dissociation rate constants varied widely between enz ... | 2017 | 28835096 |
| chemical interrogation of luxr-type quorum sensing receptors reveals new insights into receptor selectivity and the potential for interspecies bacterial signaling. | cell-cell signaling between bacteria, including quorum-sensing (qs) communication systems, may play a role in the establishment and maintenance of polymicrobial communities. to better understand and model these interactions, we must uncover the degree to which neighboring species recognize each another's signals. in the current study, we tested the likelihood of whether the qs systems of two opportunistic pathogens (acinetobacter baumannii and pseudomonas aeruginosa) that frequently arise in pol ... | 2017 | 28829573 |
| antimicrobial activity of octenidine against multidrug-resistant gram-negative pathogens. | multidrug-resistant (mr) gram-negative (gn) pathogens pose a major and growing threat for healthcare systems, as therapy of infections is often limited due to the lack of available systemic antibiotics. well-tolerated antiseptics, such as octenidine dihydrochloride (oct), may be a very useful tool in infection control to reduce the dissemination of mrgn. this study aimed to investigate the bactericidal activity of oct against international epidemic clones of mrgn. a set of five different species ... | 2017 | 28825186 |
| [distribution and drug resistance of pathogens at hematology department of jiangsu province from 2014 to 2015: results from a multicenter, retrospective study]. | objective: to describe the distribution and drug resistance of pathogens at hematology department of jiangsu province from 2014 to 2015 to provide reference for empirical anti-infection treatment. methods: pathogens were from hematology department of 26 tertiary hospitals in jiangsu province from 2014 to 2015. antimicrobial susceptibility testing was carried out according to a unified protocol using kirby-bauer method or agar dilution method. collection of drug susceptibility results and corresp ... | 2017 | 28810329 |
| conessine as a novel inhibitor of multidrug efflux pump systems in pseudomonas aeruginosa. | holarrhena antidysenterica has been employed as an ethnobotanical plant for the treatment of dysentery, diarrhoea, fever, and bacterial infections. biological activities of the principle compound, conessine including anti-diarrhoea and anti-plasmodial effects were documented. our previous study reported potency of holarrhena antidysenterica extract and conessine as resistance modifying agents against extensively drug-resistant acinetobacter baumannii. this study aimed to investigate (i) whether ... | 2017 | 28806947 |
| bacterial infections post-living-donor liver transplantation in egyptian hepatitis c virus-cirrhotic patients: a single-center study. | to determine risk factors, causative organisms and antimicrobial resistance of bacterial infections following living-donor liver transplantation (ldlt) in cirrhotic patients. | 2017 | 28804572 |