Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| assessing the progression of chronic periodontitis using subgingival pathogen levels: a 24-month prospective multicenter cohort study. | the diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. the aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients. | 2017 | 28093069 |
| analysis of the expression of nlrp3 and aim2 in periapical lesions with apical periodontitis and microbial analysis outside the apical segment of teeth. | to detect the distribution and expression levels of the nucleotide-binding oligomerization domain-like receptor protein 3 (nlrp3) and the absent in melanoma 2 (aim2) inflammasomes in periapical lesions and to analyse the possible microbial stimuli outside of teeth. | 2017 | 28193569 |
| a double-blind randomized trial comparing implants with laser-microtextured and machined collar surfaces: microbiologic and clinical results. | the purpose of this study was to compare the clinical outcome of and determine the differences in periodonto-pathogenic microbiota around two types of implant collar surfaces: laser-microtextured (test) vs machined (control). | 2017 | 27632268 |
| butyrate production under aerobic growth conditions by engineered escherichia coli. | butyrate is an important industrial platform chemical. although several groups have reported butyrate production under oxygen-limited conditions by a native producer, clostridium tyrobutylicum, and by a metabolically engineered escherichia coli, efforts to produce butyrate under aerobic growth conditions have met limited success. here, we constructed a novel butyrate synthetic pathway that functions under aerobic growth conditions in e. coli, by modifying the 1-butanol synthetic pathway reported ... | 2017 | 28089378 |
| prevalence of eight putative periodontal pathogens in atherosclerotic plaque of coronary artery disease patients and comparing them with noncardiac subjects: a case-control study. | the study was aimed to assess the prevalence of periodontal pathogens namely tannerella forsythia (t.f), campylobacter rectus (c.r), eikenella corrodens (e.c), porphyromonas gingivalis (p.g), treponema denticola (t.d), prevotella nigrescens (p.n) ,aggregatibacter actinomycetemcomitans (a.a), p.g (fi ma gene) and prevotella intermedia (p.i), in the subgingival and the atheromatous plaque of patients with coronary artery disease (cad), and comparing them with the noncardiac subjects thereby indica ... | 2017 | 26096116 |
| evaluation of a hydrophobic gel adhering to the gingiva in comparison with a standard water-soluble 1% chlorhexidine gel after scaling and root planing in patients with moderate chronic periodontitis. a randomized clinical trial. | to evaluate the clinical, microbiological and enzymatic activity of a hydrophobic chlorhexidine-based gingiva-adhering gel containing herbal ingredients, compared with a commercially available 1% chlorhexidine water-soluble gel, during non-surgical therapy of moderate chronic periodontitis. | 2017 | 26053503 |
| reproducibility of a commercially available subgingival plaque sampling strategy and analysis strategy with oligonucleotide probes. | the aim was to evaluate the intra-test agreement of pooled samples from the deepest periodontal pocket of each quadrant with a commercially available test kit based on hybridization of 16s rrna. | 2017 | 28325127 |
| effects of periodontal treatment on primary sjȫgren's syndrome symptoms. | the aim of this longitudinal prospective study was to evaluate the effects of periodontal treatment on the clinical, microbiological and immunological periodontal parameters, and on the systemic activity (essdai) and subjective (esspri) indexes in patients with primary sjögren's syndrome (pss). twenty-eight female patients were divided into four groups: pss patients with or without chronic periodontitis (scp, sc, respectively), and systemically healthy patients with or without chronic periodonti ... | 2017 | 28099577 |
| secretable small rnas via outer membrane vesicles in periodontal pathogens. | micrornas (mirnas) have been shown to be major regulators of eukaryotic gene expression. however, bacterial rnas comparable in size to eukaryotic mirnas (18-22 nucleotides) have received little attention. recently, a novel class of small rnas similar in size to mirnas (mirna-size, small rnas or msrnas) have also been found in several bacteria. like mirnas, msrnas are approximately 15 to 25 nucleotides in length, and their precursors are predicted to form a hairpin loop secondary structure. here, ... | 2017 | 28068479 |
| high-risk periodontal pathogens contribute to the pathogenesis of atherosclerosis. | periodontal disease (pd) is generated by microorganisms. these microbes can enter the general circulation causing a bacteraemia. the result can be adverse systemic effects, which could promote conditions such as cardiovascular disease. level a evidence supports that pd is independently associated with arterial disease. pd is a common chronic condition affecting the majority of americans 30 years of age and older. atherosclerosis remains the largest cause of death and disability. studies indicate ... | 2017 | 27899684 |
| comparison of two different sampling methods for subgingival plaque: subgingival paper points or mouthrinse sample? | the collection of subgingival plaque samples with paper points is time-consuming and accident-sensitive. however, the collection of saliva is simple and contains pathogens of all intraoral surfaces. the aim of this study is to investigate whether a sampling strategy with mouthrinse (mouthrinse sample [msp]; test) leads to results comparable with standard sampling method (multiple site test from the deepest pocket of each quadrant [mt4]; control). | 2017 | 27786617 |
| periodontal bacteria in the genital tract: are they related to adverse pregnancy outcome? | one of the most important factors implicated in preterm birth (ptb) is acute genitourinary tract infection. the bacteria causing chronic periodontal inflammation include gram-negative rods and anaerobes similar to those found in women with bacterial vaginosis. the aim of this prospective study is to investigate the relationship between oral and vaginal microflora and preterm low birth weight. real-time polymerase chain reaction was used to detect both the presence and level of six periodontitis- ... | 2017 | 24355228 |
| a novel glycan modifies the flagellar filament proteins of the oral bacterium treponema denticola. | while protein glycosylation has been reported in several spirochetes including the syphilis bacterium treponema pallidum and lyme disease pathogen borrelia burgdorferi, the pertinent glycan structures and their roles remain uncharacterized. herein, a novel glycan with an unusual chemical composition and structure in the oral spirochete treponema denticola, a keystone pathogen of periodontitis was reported. the identified glycan of mass 450.2 da is composed of a monoacetylated nonulosonic acid (n ... | 2017 | 27696564 |
| quantitative analysis of periodontal pathogens in periodontitis and gingivitis. | periodontal tissues surround the teeth and provide their attachment. periodontal diseases include a mild and reversible form named gingivitis and periodontitis that is the main cause of tooth loss in adults. gingivitis, that affects gums and coronal junctional epithelium, as well as periodontitis, that is characterized by loss of connective tissue attachment, are caused by a persistent inflammatory response promoted by alteration of periodontal biofilm. the aim of the study was to test whether t ... | 2017 | 26511188 |
| the infectious etiology of alzheimer's disease. | inflammation is a part of the first line of defense of the body against invasive pathogens, and plays a crucial role in tissue regeneration and repair. a proper inflammatory response ensures the suitable resolution of inflammation and elimination of harmful stimuli, but when the inflammatory reactions are inappropriate it can lead to damage of the surrounding normal cells. the relationship between infections and alzheimer's disease (ad) etiology, especially late-onset ad (load) has been continuo ... | 2017 | 28294067 |
| 1,2-diacylglycerol choline phosphotransferase catalyzes the final step in the unique treponema denticola phosphatidylcholine biosynthesis pathway. | treponema denticola synthesizes phosphatidylcholine through a licca-dependent cdp-choline pathway identified only in the genus treponema. however, the mechanism of conversion of cdp-choline to phosphatidylcholine remained unclear. we report here characterization of tde0021 (herein designated cpt) encoding a 1,2-diacylglycerol choline phosphotransferase homologous to choline phosphotransferases that catalyze the final step of the highly conserved kennedy pathway for phosphatidylcholine synthesis ... | 2017 | 28009086 |
| influence of glycemic control on the levels of subgingival periodontal pathogens in patients with generalized chronic periodontitis and type 2 diabetes. | this study evaluated the influence of glycemic control on the levels and frequency of subgingival periodontal pathogens in patients with type 2 diabetes mellitus (dm) and generalized chronic periodontitis (chp). | 2017 | 28198980 |
| molecular-level evaluation of selected periodontal pathogens from subgingival regions in canines and humans with periodontal disease. | dogs commonly serve as a model for various human conditions, including periodontal diseases. the aim of this study was to identify the anaerobic bacteria that colonize the subgingival areas in dogs and humans by using rapid real-time polymerase chain reaction (rt-pcr)-based tests and to compare the results obtained in each species. bacterial microflora evaluations, both quantitative and qualitative, were performed by applying ready-made tests on twelve dogs and twelve humans. five samples were c ... | 2017 | 27297417 |
| microbial colonization at the implant-abutment interface and its possible influence on periimplantitis: a systematic review and meta-analysis. | the aim of this systematic review and meta-analysis was to evaluate the microbial colonization at the implant-abutment interfaces (iai) on bone-level implants and to identify possible association with peri-implant conditions. | 2017 | 28359872 |
| sequential colonization of periodontal pathogens in induction of periodontal disease and atherosclerosis in ldlrnull mice. | periodontal disease (pd) and atherosclerotic vascular disease (asvd) are both chronic inflammatory diseases with a polymicrobial etiology and have been epidemiologically associated. the purpose is to examine whether periodontal bacteria that infect the periodontium can also infect vascular tissues and enhance pre-existing early aortic atherosclerotic lesions in ldlrnull mice. mice were orally infected with intermediate bacterial colonizer fusobacterium nucleatum for the first 12 weeks followed b ... | 2017 | 28104616 |
| cross-sectional evaluation of periodontal status and microbiologic and rheumatoid parameters in a large cohort of patients with rheumatoid arthritis. | this study evaluates periodontal conditions and microbiologic findings and their influence on rheumatologic disease parameters in patients with rheumatoid arthritis (ra). | 2017 | 27858553 |
| evaluation of bacteriological profile in the apical root segment of the patients with primary apical periodontitis. | apical periodontitis usually results from bacterial accumulation and contamination occurring in the root-canal system, and extending beyond the apical foramen to involve the periapical tissues. literature has a paucity of the studies that stress on the division and analysis of the pulp canal segments. the reason for this disparity might be the technique used for collecting the samples from the pulp canals. hence, we carried out the present study to evaluate the microbial flora in the apical part ... | 2017 | 28050984 |
| the risk reduction of recurrent periodontal pathogens of local application minocycline hcl 2% gel, used as an adjunct to scaling and root planing for chronic periodontitis treatment. | the aim of this study was to evaluate the clinical and microbiological effects of local application minocycline hcl 2% gel, used as an adjunct to scaling and root planing (srp) for treatment of chronic periodontitis (cp). cp is an inflammation of periodontal tissue that is caused mainly by bacterial infection, where periodontal destruction such as loss of attachment and bone destruction occurred. | 2017 | 28331333 |
| clinical and microbiological efficacy of 4% garcinia mangostana l. pericarp gel as local drug delivery in the treatment of chronic periodontitis: a randomized, controlled clinical trial. | the aim of the present study was to assess the periodontal status of individuals and the presence of red complex microorganisms (rcm), such as treponema denticola (td), porphyromonas gingivalis, and tannerella forsythia in the subgingival tissues of periodontitis patients before and after the application of 4% mangostana gel (garcinia mangostana [mga]) as an adjunct to scaling and root planing (srp). | 2017 | 28321995 |
| "association of periodontopathic anaerobic bacterial co-occurrence to atherosclerosis" - a cross-sectional study. | epidemiological studies have shown a link between periodontitis and atherosclerosis. hence the present study was chosen to assess the presence of eight anaerobic periodontal pathogens and their virulence genes in subgingival plaque (sgp) and atheromatous plaque (ap) of patients who underwent coronary artery bypass graft surgery (cabg). | 2017 | 28189829 |
| [the relationship of molecular genetic markers with clinical signs and risk factors of periodontitis]. | the study revealed positive correlation between bleeding on probing and teeth loss risk with periodontal hypercolonization by porphyromonas gingivalis, prevotella intermedia and treponema denticola. pathological tooth mobility was associated with hypercolonization by p. intermedia and tannerella forsythensis. expression of il8, tnf-α, mmp8 and mmp9 genes was also assessed in patient groups divided according to the depth of periodontal pockets and-the severity of chronic periodontitis revealing i ... | 2017 | 27876716 |
| a novel rat model of polymicrobial peri-implantitis: a preliminary study. | peri-implantitis is a complex polymicrobial biofilm-induced inflammatory osteolytic gingival infection that results in orofacial implant failures. to the best knowledge of the authors, there are no preclinical in vivo studies in implant dentistry that have investigated the inflammatory response to known microbial biofilms observed in humans. the aim of this study is to develop a novel peri-implant rat model using an established model of polymicrobial periodontitis. | 2017 | 27786620 |
| treponema denticola, porphyromonas gingivalis, and tannerella forsythia induce cell death and release of endogenous danger signals. | the aim of this study was to analyze whether periodontopathogens induced inflammatory cell death and the release of diverse endogenous danger molecules in thp-1-derived macrophages. | 2017 | 27697692 |
| persistence of porphyromonas gingivalis is a negative predictor in patients with moderate to severe periodontitis after nonsurgical periodontal therapy. | the aim of this study was to evaluate the quality of prediction for stable results after nonsurgical periodontal therapy by several microbiological variables of the subgingival biofilm and biomarkers of gingival crevicular fluid or oral lavage. | 2017 | 27558382 |
| microbiological and ammp-8 findings depending on peri-implant disease in patients undergoing supportive implant therapy. | the aim of this study was to evaluate microbiological findings and ammp-8 level of peri-implant mucositis (m) and peri-implantitis (p) in patients undergoing supportive implant therapy (sit). eighty-nine patients with 171 implants were included. the case definitions were as follows: m: ppd ≥4mm, bop; p: ppd≥4mm, bop, radiographic bone loss ≥3.5mm. samples of peri-implant sulcular fluid (pisf) were taken from all peri-implant pockets at each implant to detect periodontal pathogens using pcr and a ... | 2017 | 28274501 |
| polymerase chain reaction to evaluate the efficacy of silica dioxide colloidal solutions in the treatment of chronic periodontitis: a case control study. | the objective of this study was to compare the efficacy of supportive periodontal therapy [i.e. scaling and rooth planing (srp)] alone versus a chemical silica dioxide (sio2) colloidal solution (sdcs) device used in association with srp in the treatment of chronic periodontitis in adult patients. a total of 20 patients with a diagnosis of chronic periodontitis (40 localized chronic periodontitis sites) in the age group of 35 to 55 were selected. none of these patients had previously received any ... | 2017 | 26511193 |
| the c- terminal region of the major outer sheath protein (msp) of treponema denticola inhibits neutrophil chemotaxis. | treponema denticola is an oral spirochete strongly associated with severe periodontal disease. a prominent virulence factor, the major outer sheath protein (msp), disorients neutrophil chemotaxis by altering the cellular phosphoinositide balance, leading to impairment of downstream chemotactic events including actin rearrangement, rac1 activation and akt activation in response to chemoattractant stimulation. the specific regions of msp responsible for interactions with neutrophils remain unknown ... | 2017 | 28296262 |
| comparative analysis of motility and other properties of treponema denticola strains. | the periodontitis-associated pathogen treponema denticola is a spirochetal bacterium that swims by rotating its cell body like a corkscrew using periplasmic flagella. we compared physiologic and pathogenic properties, including motility, in four strains of t. denticola. phase-contrast microscopy showed differential motility between the strains; atcc 35404 showed the highest motility, followed by atcc 33521, and the remaining two strains (atcc 35405 and atcc 33520) showed the lowest motility. tra ... | 2017 | 27914958 |
| multilocus sequence analysis of phylogroup 1 and 2 oral treponeme strains. | more than 75 "species-level" phylotypes of spirochete bacteria belonging to the genus treponema reside within the human oral cavity. the majority of these oral treponeme phylotypes correspond to as-yet-uncultivated taxa or strains of uncertain standing in taxonomy. here, we analyze phylogenetic and taxonomic relationships between oral treponeme strains using a multilocus sequence analysis (mlsa) scheme based on the highly conserved 16s rrna, pyrh, reca, and flaa genes. we utilized this mlsa sche ... | 2017 | 27864174 |
| prevalence of periodontal pathogens among italian patients with chronic periodontitis: a retrospective study on 2992 patients. | the aim of the present study was to evaluate the prevalence of some periodontal pathogens in italian adults with chronic periodontitis. | 2017 | 28757933 |
| the association of periodontopathic bacteria levels in saliva and tongue coating with oral malodor in periodontitis patients. | to elucidate the association oral malodor with the levels of periodontopathic bacteria in saliva and tongue coating of periodontitis patients with oral malodor. | 2017 | 28674708 |
| chronic periodontal disease, periodontal pathogen colonization, and an increased risk of precancerous gastric lesions. | the present study assessed the association between periodontal pathogen colonization and the potential risk of developing precancerous lesions of gastric cancer (plgc) in a clinical setting. | 2017 | 28671506 |
| effects of photodynamic therapy in periodontal treatment: a randomized, controlled clinical trial. | to evaluate the effects of photodynamic therapy (pdt) in the nonsurgical treatment of chronic periodontitis. | 2017 | 28667678 |
| putative periodontal pathogens in the subgingival plaque of sudanese subjects with aggressive periodontitis. | there has been limited study of the bacterial species associated with aggressive periodontitis (agp) in high-risk populations in africa. the aim of this study was to investigate and quantify the presence of four putative periodontal pathogens in the subgingival plaque of sudanese subjects with agp. a secondary aim was to investigate the effect of varying the detection threshold on the reported prevalence of the bacterial species investigated. | 2017 | 28499236 |
| risk of superinfection in peri-implantitis after systemic broad spectrum antibiotics. | peri-implant disease has developed over the last few years as a complication that is often difficult to resolve. the disease process is mainly attributed to bacterial infection. proposed combined therapies use broad-spectrum antibiotics to halt its progression. a major associated risk is the undetected development of superinfections that are difficult to eradicate. a group of healthy individuals with advanced peri-implantitis (pi) were referred for evaluation due to severe, rapidly progressive b ... | 2017 | 28854287 |
| quantification by qpcr of pathobionts in chronic periodontitis: development of predictive models of disease severity at site-specific level. | currently, there is little evidence available on the development of predictive models for the diagnosis or prognosis of chronic periodontitis based on the qpcr quantification of subgingival pathobionts. our objectives were to: (1) analyze and internally validate pathobiont-based models that could be used to distinguish different periodontal conditions at site-specific level within the same patient with chronic periodontitis; (2) develop nomograms derived from predictive models. subgingival plaqu ... | 2017 | 28848499 |
| microbiological response to periodontal therapy and multivariable prediction of clinical outcome. | this study assessed the microbiological effects of a 2-phase antimicrobial periodontal therapy and tested microbiological, clinical, and biological markers as prognostic indicators for clinical success. | 2017 | 28844191 |
| periodontal microbioma and rheumatoid arthritis: the role of porhyromonas gingivalis. | rheumatoid arthritis is a disease, which can be described as an autoimmune response after molecular mimicry caused by infective agents. the current study aims at evaluating the correlation between rhematoid arthritis (ra) and periodontal disease (pd), with special attention to the microbioma detected in the gums. thirty-four patients with rd were recruited into the current study. among rheumatic parameters, rheumatoid factor (rf), anti-citrullinated protein antibody (ccp), hla-bdr1 and das28 wer ... | 2017 | 28691459 |
| simultaneous detection of oral pathogens in subgingival plaque and prostatic fluid of men with periodontal and prostatic diseases. | chronic prostatitis (cpr) and benign prostatic hyperplasia (bph) are complex inflammatory conditions for which etiologic determinants are still poorly defined. periodontitis is caused by subgingival colonizing bacteria in the oral cavity. the causal effect of periodontal disease on prostatic inflammation has not been established. the purpose of this study is to isolate oral pathogens from expressed prostatic secretions of patients with periodontal disease and cpr or bph. | 2017 | 28548883 |
| effect of pranayama on ppar-γ, nf-κb expressions and red complex microorganisms in patients with chronic periodontitis - a clinical trial. | sudarshankriya pranayama is the control of breathing movements to regulate the energy flow throughout the body, which has shown to positively affect immune function, autonomic nervous system and psychologic-neuro pathways. the practice of pranayama has been proven to show several benefits such as reduction in stress levels, relieves anxiety and depression, increase in antioxidant levels, reduces insulin resistance and improves respiratory function. | 2017 | 28764300 |
| effect of azithromycin on a red complex polymicrobial biofilm. | azithromycin has recently gained popularity for the treatment of periodontal disease, despite sparse literature supporting efficiency in treating periodontal bacterial biofilms. the aim of this study was to evaluate the effect of azithromycin on biofilms comprised of porphyromonas gingivalis, treponema denticola, and tannerella forsythia in comparison to an amoxicillin and metronidazole combination. p. gingivalis w50, t. denticola atcc35405, and t. forsythia atcc43037 grown under anaerobic condi ... | 2017 | 28748041 |
| periodontal pathogens in the etiology of pancreatic cancer. | pancreatic cancer is the fourth leading cause of cancer-related deaths worldwide. chronic pancreatitis is frequently observed in patients with pancreatic cancer, and a significant relationship between orodigestive cancer-related deaths and chronic periodontitis has been detected. porphyromonas gingivalis, tannerella forsythia, and treponema denticola, collectively called the red complex, are the major pathogens responsible for chronic periodontitis and secrete peptidylarginine deiminase. anti-p. ... | 2017 | 28611978 |
| biomarkers and bacteria around implants and natural teeth in the same individuals. | this cross-sectional study assesses cytokine levels in peri-implant crevicular fluid (picf)/gingival crevicular fluid (gcf) and a selection of subgingival/submucosal plaque bacteria from clinically healthy or diseased sites in the same individuals. | 2017 | 28440740 |
| infection and apoptosis associated with inflammation in periodontitis: an immunohistologic study. | evidence of increased apoptosis is observed in periodontitis and may be associated with destruction of the periodontal tissue caused by the increased cell death, with the release of danger signals and subsequent stimulation of the proinflammatory processes. however, the exact mechanisms associated with these processes remain unclear. this study aimed to investigate the presence of the periodontal pathogen treponema denticola, apoptosis, high mobility group box 1 as a damage-associated molecular ... | 2017 | 28686335 |
| salivary, gingival crevicular fluid and serum levels of ghrelin and chemerin in patients with periodontitis and overweight. | nutrition and body weight are modifying factors for periodontitis. the purpose of this study was to quantify two molecules (ghrelin and chemerin), released in association with food intake and obesity, in periodontally healthy and diseased individuals with respect to different body mass categories. | 2017 | 28631313 |
| effect of surgical periodontal treatment associated to antimicrobial photodynamic therapy on chronic periodontitis: a randomized controlled clinical trial. | this randomized controlled clinical trial evaluated the effects of an adjunctive single application of antimicrobial photodynamic therapy (apdt) in surgical periodontal treatment (st) in patients with severe chronic periodontitis (scp). | 2017 | 28498507 |
| oral treponeme major surface protein: sequence diversity and distributions within periodontal niches. | treponema denticola and other species (phylotypes) of oral spirochetes are widely considered to play important etiological roles in periodontitis and other oral infections. the major surface protein (msp) of t. denticola is directly implicated in several pathological mechanisms. here, we have analyzed msp sequence diversity across 68 strains of oral phylogroup 1 and 2 treponemes; including reference strains of t. denticola, treponema putidum, treponema medium, 'treponema vincentii', and 'trepone ... | 2017 | 28453906 |
| microbial profile comparisons of saliva, pooled and site-specific subgingival samples in periodontitis patients. | the purpose of this study was to compare microbial profiles of saliva, pooled and site-specific subgingival samples in patients with periodontitis. we tested the hypotheses that saliva can be an alternative to pooled subgingival samples, when screening for presence of periopathogens. | 2017 | 28800622 |
| treponema denticola invasion into human gingival epithelial cells. | host cell invasion is important for periodontal pathogens in evading host defenses and spreading into deeper areas of the periodontal tissue. treponema denticola has been implicated in a number of potentially pathogenic processes, including periodontal tissue penetration. here we tested the ability of t. denticola strains to invade human gingival epithelial cells (hgec). after 2 h infection, intracellular location of t. denticola cells was confirmed by confocal laser scanning microscopy (clsm). ... | 2016 | 26806000 |
| cadmium sulphide quantum dots with tunable electronic properties by bacterial precipitation. | we present a new method to fabricate semiconducting, transition metal nanoparticles (nps) with tunable bandgap energies using engineered escherichia coli. these bacteria overexpress the treponema denticola cysteine desulfhydrase gene to facilitate precipitation of cadmium sulphide (cds) nps. analysis with transmission electron microscopy, x-ray diffraction, and x-ray photoelectron spectroscopy reveal that the bacterially precipitated nps are agglomerates of mostly quantum dots, with diameters th ... | 2016 | 28435671 |
| essential role of the linker region in the higher catalytic efficiency of a bifunctional msra-msrb fusion protein. | many bacteria, particularly pathogens, possess methionine sulfoxide reductase a (msra) and b (msrb) as a fusion form (msrab). however, it is not clear why they possess a fusion msrab form rather than the separate enzymes that exist in most organisms. in this study, we performed biochemical and kinetic analyses of msrab from treponema denticola (tdmsrab), single-domain forms (tdmsra and tdmsrb), and catalytic cys mutants (tdmsrab(c11s) and tdmsrab(c285s)). we found that the catalytic efficiency o ... | 2016 | 27551953 |
| evaluation of the efficacy of a new oral gel as an adjunct to home oral hygiene in the management of chronic periodontitis. a microbiological study using pcr analysis. | the use of chemical devices for non-surgical periodontal therapy has led to new treatment strategies aiming primarily at infection control and oral bacterial load. over the last few decades adjunctive chemical devices has been subjected to many scientific and medical studies. the purpose of the present study was to assess the effect of a new oral gel named parodongel on the red complex organisms using polymerase chain reaction (pcr) for microbiological analysis. a total of 10 patients with a dia ... | 2016 | 27469558 |
| comparative analysis of calcium-binding myeloid-related protein-8/14 in saliva and serum of patients with periodontitis and healthy individuals. | this study aims to investigate calcium-binding myeloid-related protein (mrp)-8/14 in the saliva and serum of individuals with periodontitis and periodontally healthy individuals for the assessment of its role in the pathogenesis and clinical diagnosis of periodontitis. | 2016 | 26447749 |
| microbiologic findings in relation to risk assessment for periodontal disease: a cross-sectional study. | in this study, an association between a computerized risk calculator and microbiologic testing is examined in patients with periodontitis. | 2016 | 26291297 |
| association between maternal periodontitis and preterm and/or low birth weight infants in normal pregnancies. | to relate the periodontal condition with the presence of periodontal bacteria in pregnant that had babies with preterm delivery or/and low weight at birth (ptlbw). | 2016 | 25394610 |
| [gender-related marker pathogens of periodontal disease in chronic periodontitis]. | by using qpcr system, women as well as men were found to have an equal periodontal pathogen colonization. however, the women are subjected to have a higher risk of chronic periodontitis onsets. women with the chronic periodontitis usually expose an evident hypercolonization with a single pathogen. p. gingivalis is the most prevalent causative agent of the chronic periodontitis in women but not in men. in health as well as in the chronic periodontitis a complex of periodontal pathogens forms such ... | 2016 | 27367192 |
| the influences of periodontal status and periodontal pathogen quantity on salivary 8-hydroxydeoxyguanosine and interleukin-17 levels. | periodontitis is a biofilm-initiated disease that is characterized by elevated inflammatory status. 8-hydroxydeoxyguanosine (8-ohdg) and interleukin (il)-17 are highly associated with inflammation and bone resorption and therefore are regarded as potential biomarkers for periodontitis. in this study, the associations between salivary 8-ohdg and il-17 levels and clinical and microbial parameters before and after non-surgical treatment are investigated. | 2016 | 26654345 |
| bacterial interactions in pathogenic subgingival plaque. | chronic periodontitis has a polymicrobial biofilm aetiology. polymicrobial biofilms are complex, dynamic microbial communities formed by two or more bacterial species that are important for the persistence and proliferation of participating microbes in the environment. interspecies adherence, which often involves bacterial surface-associated molecules, and communications are essential in the spatial and temporal development of a polymicrobial biofilm, which in turn is necessary for the overall f ... | 2016 | 26541672 |
| polymicrobial infection alter inflammatory microrna in rat salivary glands during periodontal disease. | periodontal disease initiated by subgingival pathogens is linked with diminished secretion of saliva, and implies pathogenic bacteria dissemination to or affects secondary sites such as the salivary glands. micrornas activated in response to bacteria may modulate immune responses against pathogens. therefore, sprague-dawley rats were infected by oral lavage consisting of polymicrobial inocula, namely porphyromonas gingivalis, tannerella forsythia, and treponema denticola, or sham-infected for 12 ... | 2016 | 26481834 |
| rapid identification and quantitation for oral bacteria based on short-end capillary electrophoresis. | high-speed capillary electrophoresis (hsce) is a promising technology applied in ultra-rapid and high-performance analysis of biomolecules (such as nucleic acids, protein). in present study, the short-end capillary electrophoresis coupled with one novel space domain internal standard method (sdis) was employed for the rapid and simultaneous analysis of specific genes from three oral bacteria (porphyromonas gingivalis (p.g), treponema denticola (t.d) and tannerela forsythia (t.f)). the reliabilit ... | 2016 | 27591633 |
| periodontitis contributes to adipose tissue inflammation through the nf-<kappa>b, jnk and erk pathways to promote insulin resistance in a rat model. | this study aimed to investigate the mechanism by which periodontitis affects the inflammatory response and systemic insulin resistance in the white adipose and liver tissues in an obese rat model. the obese model was generated by feeding rats a high fat diet. the periodontitis model was induced by ligatures and injection of "red complex", which consisted of porphyromonas gingivalis, treponema denticola, and tannerella forsythia, for two weeks. when compared with rats without periodontitis, fasti ... | 2016 | 27565999 |
| impact of heavy smoking on the clinical, microbiological and immunological parameters of patients with dental implants: a prospective cross-sectional study. | the aim of the present study was to investigate how heavy smoking influences the clinical, microbiological, and host-response characteristics in peri-implant sulcus fluid of patients with healthy dental implants. | 2016 | 26171870 |
| evaluation of efficacy of photodynamic therapy as an adjunct to nonsurgical periodontal therapy in treatment of chronic periodontitis patients: a clinico-microbiological study. | photodynamic therapy (pdt) is a local noninvasive treatment modality without side effects caused by antibiotics. the aim of this study was to evaluate the efficacy of adjunctive use of pdt with scaling and root planing as compared with srp alone in the treatment of chronic periodontitis. | 2016 | 27966504 |
| bacteria prevalence in a large italian population sample: a clinical and microbiological study. | the present study detects those bacterial species which are more strongly related to bleeding on probing, suppuration and smoking in periodontal-affected patients. nine hundred and fifty-one patients with periodontal diseases were admitted to the department of periodontology and implantology, dental school of bologna university where they underwent microbiological tests for six periodontal pathogens (actinomyces actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, treponema de ... | 2016 | 27469569 |
| impact of implant-abutment connection on osteoimmunological and microbiological parameters in short implants: a randomized controlled clinical trial. | the study aimed to determine the levels of soluble receptor activator of nuclear factor-кb ligand (srankl) and osteoprotegerin (opg) as well as their relative calculated ratio in peri-implant crevicular fluid (picf) obtained around two different types of implant-abutment connection on short implants following a 12-month monitoring period. moreover, the levels of a number of oral bacterial species were investigated in the corresponding submucosal biofilm samples. | 2016 | 27469171 |
| global tlr2 and 4 deficiency in mice impacts bone resorption, inflammatory markers and atherosclerosis to polymicrobial infection. | toll-like-receptors (tlrs) play a significant role in the generation of a specific innate immune response against invading pathogens. tlr2 and tlr4 signaling contributes to infection-induced inflammation in periodontal disease (pd) and atherosclerosis. observational studies point towards a relationship between pd and atherosclerosis, but the role of tlr2 and tlr4 in the recognition of multiple oral pathogens and their modulation of host response leading to atherosclerosis are not clear. we evalu ... | 2016 | 27224005 |
| bacteria in the apical root canals of teeth with apical periodontitis. | bacteria in the tooth root canal may cause apical periodontitis. this study examined the bacterial species present in the apical root canal of teeth with apical periodontitis. antibiotic sensitivity tests were performed to evaluate whether these identified bacterial species were susceptible to specific kinds of antibiotics. | 2016 | 27745799 |
| the current weight of evidence of the microbiologic profile associated with peri-implantitis: a systematic review. | there is currently no consensus regarding microorganisms that may be considered true peri-implant pathogens. therefore, the aim of this systematic review is to determine the weight of evidence for microorganisms related to peri-implantitis based on results of association studies. | 2016 | 27420109 |
| influence of the periodontal status on the initial-biofilm formation on titanium surfaces. | dental implants will be exposed to a complex ecosystem once they are placed in the oral cavity. the bacterial colonization and biofilm formation on these devices will depend not only on the physicochemical surface implant properties but also on the periodontal health conditions of the patients, as these devices are exposed. | 2016 | 24995517 |
| microbiota at teeth and implants in partially edentulous patients. a 10-year retrospective study. | to determine the microbiota at implants and adjacent teeth 10 years after placement of implants with a sandblasted and acid-etched surface. | 2016 | 25827437 |
| spirochaete flagella hook proteins self-catalyse a lysinoalanine covalent crosslink for motility. | spirochaetes are bacteria responsible for several serious diseases, including lyme disease (borrelia burgdorferi), syphilis (treponema pallidum) and leptospirosis (leptospira interrogans), and contribute to periodontal diseases (treponema denticola)(1). these spirochaetes employ an unusual form of flagella-based motility necessary for pathogenicity; indeed, spirochaete flagella (periplasmic flagella) reside and rotate within the periplasmic space(2-11). the universal joint or hook that links the ... | 2016 | 27670115 |
| interaction of spirochetes with the host fibrinolytic system and potential roles in pathogenesis. | the pathogenic spirochetes borrelia burgdorferi, b. hermsii, b. recurrentis, treponema denticola and leptospira spp. are the etiologic agents of lyme disease, relapsing fever, periodontitis and leptospirosis, respectively. lyme borreliosis is a multi-systemic disorder and the most prevalent tick-borne disease in the northern hemisphere. tick-borne relapsing fever is persistent in endemic areas worldwide, representing a significant burden in some african regions. periodontal disease, a chronic in ... | 2016 | 25914944 |
| immunologic characteristics of human gingival fibroblasts in response to oral bacteria. | there is ample evidence that gingival fibroblasts (gfs) participate in the immune response to oral bacteria and serve as immune-regulatory cells. the objective of this study was to investigate the innate immune response of gfs to oral bacteria. | 2016 | 27558278 |
| detection of subgingival periodontal pathogens--comparison of two sampling strategies. | the aim of the study is to compare detection frequency of periodontal pathogens in patients with aggressive/severe chronic periodontitis using pooled plaque samples from the deepest pockets per quadrant/per sextant. | 2016 | 26193958 |
| association of porphyromonas gingivalis with high levels of stress-induced hormone cortisol in chronic periodontitis patients. | the aim of the present study was to evaluate the association between the occurrence of periodontopathogens with cortisol levels in chronic periodontitis patients. | 2016 | 26194628 |
| periodontal and peri-implant microbiota in patients with healthy and inflamed periodontal and peri-implant tissues. | to compare the prevalence and levels of six bacterial pathogens within the subgingival/submucosal microbiota at teeth versus implants with various clinical conditions. | 2016 | 25399962 |
| prevalence of periodontal pathogens as predictor of the evolution of periodontal status. | the aim of this study was to determine the relationship between the prevalence of porphyromonas gingivalis, its fima genotypes, aggregatibacter actinomycetemcomitans, tannerella forsythia, and treponema denticola and the evolution of periodontal health. in a longitudinal prospective study, samples of subgingival plaque were taken from 114 patients (37 with chronic periodontitis, 17 with gingivitis, and 60 periodontally healthy) in the course of a full periodontal examination. pcr was employed to ... | 2016 | 27888369 |
| generalized aggressive periodontitis: microbiological composition and clinical parameters in non-surgical therapy. | the aim of this study was to determine the variations in periodontal parameters and microbiological composition in periodontal pockets at the baseline and 3 and 6 months post treatmentin patients with generalized aggressive periodontitis(gap) undergoing non surgical periodontal treatment combined with chlorhexidine and systemic antibiotics. medical and dental history was taken from 10 subjects, average age 30.6±2.7 years, diagnosed with gap. a non surgical periodontal treatment combined with 0.1 ... | 2016 | 28383606 |
| microbial dynamics during conversion from supragingival to subgingival biofilms in an in vitro model. | the development of dental caries and periodontal diseases result from distinct shifts in the microbiota of the tooth-associated biofilm. this in vitro study aimed to investigate changes in biofilm composition and structure, during the shift from a 'supragingival' aerobic profile to a 'subgingival' anaerobic profile. biofilms consisting of actinomyces oris, candida albicans, fusobacterium nucleatum, streptococcus oralis, streptococcus mutans and veillonella dispar were aerobically grown in saliva ... | 2016 | 26033167 |
| arthritis-induced alveolar bone loss is associated with changes in the composition of oral microbiota. | rheumatoid arthritis (ra) and periodontitis (pd) are chronic inflammatory disorders that cause bone loss. pd tends to be more prevalent and severe in ra patients. previous experimental studies demonstrated that ra triggers alveolar bone loss similarly to pd. the aim of this study was to investigate if arthritis-induced alveolar bone loss is associated with modification in the oral microbiota. checkerboard dna-dna hybridization was employed to analyze forty oral bacterial species in 3 groups of c ... | 2016 | 26996070 |
| influence of highly-active antiretroviral therapy on the subgingival biofilm in hiv-infected patients. | highly-active antiretroviral therapy (haart) has been associated with alterations in subgingival biofilm and periodontal disease. the purpose of the present study was to investigate the association between different haart regimens and the prevalence of periodontal pathogens in hiv-infected patients with chronic periodontitis. | 2016 | 25283543 |
| the distribution of porphyromonas gingivalis, tannerella forsythia, treponema denticola and aggregatibacter actinomycetemcomitans in patients with alcoholic disease: a pilot study. | both drinking and periodontal disease are serious health and social problems. findings on the effect of alcohol consumption on periodontal disease are inconclusive. | 2016 | 27627556 |
| herpesviral-bacterial co-infection in mandibular third molar pericoronitis. | the aim of this study was to assess the presence of herpesviruses and periodontopathic bacteria and to establish their potential association with pericoronitis. | 2016 | 27620215 |
| effect of helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation. | helicobacter pylori (h. pylori), a pathogen inducing peptic disease, is recently found to be binding to the progress of periodontitis. most previous studies are case-controlled, and they investigate the risk of h. pylori infection in disease the development of while few studies evaluate the correlation between h. pylori and periodontal pathogens. therefore, we investigated the correlation between h. pylori infection with periodontal parameters, periodontal pathogens and inflammation. the results ... | 2016 | 27602578 |
| longitudinal study on clinical and microbial analysis of periodontal status in pregnancy. | this study was aimed to provide a longitudinal overview of the subgingival bacterial microbiome using fluorescence in situ hybridization (fish) technique, in women in the second trimester of pregnancy (between 14 and 24 weeks), and 48 h and 8 weeks postpartum. of 31 women evaluated during pregnancy, 24 returned for the 48-h and 18 for their 8-week exams postpartum. probing depth (pd), bleeding on probing, clinical attachment level, and presence of calculus were recorded. subgingival plaque sampl ... | 2016 | 27556678 |
| bacterial load of periodontal pathogens among italian patients with chronic periodontitis: a comparative study of three different areas. | the aim of the present study was to evaluate the mean bacterial load of some periodontal pathogenic bacteria in italian patients affected by chronic periodontitis. the sample consisted of 1,762 patients with a clinical diagnosis of chronic periodontitis based on the criteria of the american academy of periodontology sampled in the period 2013-2015; 1,323 patients were from northern italy, 317 from central italy and 122 from southern italy. samples for microbiological analysis were collected from ... | 2016 | 27469562 |
| evaluation of the efficacy of a new oral gel containing carvacrol and thymol for home oral care in the management of chronic periodontitis using pcr analysis: a microbiological pilot study. | the use of chemical devices for domestic oral hygiene in periodontal patients has led to new treatment strategies aiming primarily at a control of infection. over the last few years, carvacrol and thymol (ct) have been subjected to many scientific and medical studies. the purpose of the present study was to assess the effect of ct on the red complex bacteria using polymerase chain reaction (pcr) for microbiological analysis. five patients with a diagnosis of chronic periodontitis in the age grou ... | 2016 | 27469559 |
| [study of mutual dependence of periodontal and colonic microbiome in health and pathology using nsg-sequencing]. | by using ngs-sequencing libraries of dna from periodontal swabs with primers specific to v6 region of 16s rdna prevalence of bacterial genera and species in periodontal and colonic microbiota of patients with periodontitis of different severity and healthy donors was analyzed. hyper-colonization of the colon with akkermansia muciniphila was found to be the most important maker of negative predisposition to periodontitis (t=133,7 at р=10(-6)). this result is in a good agreement with communication ... | 2016 | 27239990 |
| [use of the real-time pcr for study of the periodontal microbiome in patients with combined pathology of gastroduodenal zone and chronic periodontitis]. | the total of 54 patients with chronic periodontitis of different severity was tested using real-time pcr (dentoflor kit). the group included 38 patients with chronic gastritis. for the first time, a higher prevalence of treponema denticola in periodontium of males in comparison with females was demonstrated. the patients with chronic gastritis had more human genome dna at their periodontium than healthy individuals. non-parametric statistical analysis demonstrated high association of periodontiu ... | 2016 | 27183718 |
| detection of five potentially periodontal pathogenic bacteria in peri-implant disease: a comparison of pcr and real-time pcr. | the aim of this study was to compare the microbial analysis methods of polymerase chain reaction (pcr) and real-time pcr (rt-pcr) in terms of detection of five selected potentially periodontal pathogenic bacteria in peri-implant disease. therefore 45 samples of healthy, mucositis and peri-implantitis (n = 15 each) were assessed according to presence of the following bacteria using pcr (dna-strip technology) and rt-pcr (fluorescent dye sybr green-system): aggregatibacter actinomycetemcomitans (aa ... | 2016 | 27142589 |
| quantitative pcr studies of aggregatibacter actinomycetemcomitans and treponema denticola/tanerella forsythensis complex as etiological factors of chronic periodontitis. | real-time quantitative pcr (dentofl or kit) was used to detect dna of periodontal pathogens in specimens from 92 patients with chronic periodontitis and from a control sample of 12 normal subjects. a bimodal distribution of patients by periodontium colonization with a. actinomycetemcomitans, p. gingivalis, p. intermedia, t. forsythensis, and t. denticola was demonstrated. a new approach to interpretation of the results of quantitative evaluation of periodontal pathogens, including the notion of ... | 2016 | 26899837 |
| microbiological distribution of six periodontal pathogens between untreated italian and dutch periodontal patients. | to compare prevalence and microbial load of six periodontal pathogens between italian and dutch patients affected by chronic periodontitis, using oligonucleotide probe technology. | 2016 | 26870849 |
| antibacterial activity of curcumin against periodontopathic bacteria. | curcumin is a polyphenol extracted from root of turmeric and known to possess multifunctional properties, including antibacterial activity. although previous studies have investigated the effects of curcumin on microorganisms, available knowledge on the effects of curcumin on periodontopathic bacteria is still limited. in this study, the antibacterial effect of curcumin on periodontopathic bacteria is investigated, particularly porphyromonas gingivalis. | 2016 | 26447754 |
| protein biomarkers and microbial profiles in peri-implantitis. | the aim of the present investigation was to determine the profile of peri-implant crevicular fluid (picf) biomarkers combined with microbial profiles from implants with healthy peri-implant tissues and peri-implantitis to assess real-time disease activity. | 2016 | 26424287 |
| pseudomonas aeruginosa microcolonies in coronary thrombi from patients with st-segment elevation myocardial infarction. | chronic infection is associated with an increased risk of atherothrombotic disease and direct bacterial infection of arteries has been suggested to contribute to the development of unstable atherosclerotic plaques. in this study, we examined coronary thrombi obtained in vivo from patients with st-segment elevation myocardial infarction (stemi) for the presence of bacterial dna and bacteria. aspirated coronary thrombi from 22 patients with stemi were collected during primary percutaneous coronary ... | 2016 | 28030624 |