Publications

complete genome sequence of elephant endotheliotropic herpesvirus 1a.	elephant endotheliotropic herpesvirus 1a is a member of the proboscivirus genus and is a major cause of fatal hemorrhagic disease in endangered juvenile asian elephants worldwide. here, we report the first complete genome sequence from this genus, obtained directly from necropsy dna, in which 60 of the 115 predicted genes are not found in any known herpesvirus.	2013	23580705
comparative genome analysis of four elephant endotheliotropic herpesviruses, eehv3, eehv4, eehv5, and eehv6, from cases of hemorrhagic disease or viremia.	the genomes of three types of novel endotheliotropic herpesviruses (elephant endotheliotropic herpesvirus 1a [eehv1a], eehv1b, and eehv2) associated with lethal hemorrhagic disease in asian elephants have been previously well characterized and assigned to a new proboscivirus genus. here we have generated 112 kb of dna sequence data from segments of four more types of eehv by direct targeted pcr from blood samples or necropsy tissue samples from six viremic elephants. comparative phylogenetic ana ...	2014	25231309
surviving and fatal elephant endotheliotropic herpesvirus-1a infections in juvenile asian elephants - lessons learned and recommendations on anti-herpesviral therapy.	elephant endotheliotropic herpesviruses (eehvs) can cause acute haemorrhagic disease in young asian elephants (elephas maximus) and clinical eehv infections account for the majority of their fatalities. the anti-herpesviral drug famciclovir (fcv) has been used routinely to treat viraemic at-risk elephants, but thus far without proven efficacy. this paper presents clinical and virological investigations of two eehv-1a infected elephants treated with fcv, and discusses anti-herpesvirus therapies o ...	2016	27567895
long-term, intermittent, low-level elephant endotheliotropic herpesvirus 1a viremia in a captive asian elephant calf.	a 2-y-old male asian elephant ( elephas maximus), with an elevated platelet count (1,100 × 109/l [1,100 × 103/mm3]), tested positive for elephant endotheliotropic herpesvirus 1a (eehv-1a) on conventional pcr (cpcr) of edta whole blood. no clinical signs were ever reported and no treatment was administered, but low-level viremia persisted for 2.5 y based on results of cpcr and/or real-time pcr (rtpcr). sequencing confirmed that the eehv-1a detected was identical at the beginning through the end o ...	2018	30264667