Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| hepatitis b virus genotypes: a south pacific perspective. | 87-91% but still, 0.6% of those that did respond to vaccination became infected. the infection rate of the vaccinated populations in the pacific islands ranged between 0.7 and 3.8%, which is comparable to taiwan. a vigorous polyclonal response this communication discusses the current status of research in the hepatitis b virus in relation to the south pacific. the hepatitis b virus (hbv) is a small dna virus--3200 nucleotides. it has a circular genome and replicates through an rna intermediate g ... | 2001 | 12017822 |
| genotypes and clinical phenotypes of hepatitis b virus in patients with chronic hepatitis b virus infection. | genotype c of hepatitis b virus (hbv) has been shown to be associated with a poor clinical outcome, compared to genotype b. to explore the clinical phenotypes, with special reference to the seroconversion of hepatitis b e antigen (hbeag) and frequency of acute exacerbation between patients infected with hbv genotypes b and c, a cohort of 272 taiwanese patients with chronic hbv infection was analyzed. according to the status of hbeag at enrollment and frequency of acute exacerbation during the fo ... | 2002 | 11923332 |
| hbv genotype b is associated with better response to interferon therapy in hbeag(+) chronic hepatitis than genotype c. | hepatitis b virus (hbv) genotype and precore/core promoter mutations have been implicated in spontaneous and interferon alfa (ifn-alpha)-related hepatitis b e antigen (hbeag) seroconversion. we performed a retrospective analysis of a previously reported randomized controlled trial to determine the effects of hbv genotype and precore/core promoter mutations on ifn-alpha response in patients with hbeag-positive chronic hepatitis. clinical data and stored sera from 109 (95%) patients in the origina ... | 2002 | 12447868 |
| viral genotypes and response to interferon in patients with acute prolonged hepatitis b virus infection of adulthood in japan. | acute hepatitis b virus (hbv) infection was diagnosed in 57 adults admitted to toranomon hospital in tokyo, japan. genotypes of hbv were determined by a serological method and compared to those in 1,077 patients with chronic hepatitis b. the distribution of genotypes were: genotype a (acute, 22.8% vs. chronic, 1.9%; p < 0.00001); b (14.0% vs. 9.4%); c (43.9% vs. 87.7%, p = 0.004); d (1.8% vs. 0.2%); f (1.8% vs. 0.2%); and unable to be typed (15.8% vs. 0.6%, p = 0.001). the infection persisted in ... | 2002 | 12376960 |
| preponderance of hepatitis b virus genotype b contributes to a better prognosis of chronic hbv infection in okinawa, japan. | the present study was designed to examine the distribution of hepatitis b virus (hbv) genotypes among patients at various stages of chronic liver disease type b in okinawa prefecture, japan, where the prevalence of hepatitis b surface antigen is the highest in japan despite the lowest mortality rate from primary liver cancer. serum samples from 227 hbv carriers were determined for hbv genotype by polymerase chain reaction (pcr)-restriction fragment length polymorphism. five of 227 sera were nega ... | 2002 | 12115993 |
| hepatitis b virus genotype b is associated with earlier hbeag seroconversion compared with hepatitis b virus genotype c. | recent studies suggest that hepatitis b virus (hbv) genotype b is associated with less active liver disease than hbv genotype c. the aim of our study was to determine if hbv genotype b is associated with higher rates of spontaneous hepatitis b e antigen (hbeag) seroconversion compared with genotype c. | 2002 | 12055581 |
| hepatitis b virus genotype c takes a more aggressive disease course than hepatitis b virus genotype b in hepatitis b e antigen-positive patients. | one hundred forty-six hepatitis b e antigen (hbeag)-positive chronic hepatitis b patients were followed up for 32 +/- 13 months. all six patients with hepatocellular carcinoma had hepatitis b virus (hbv) genotype c. disease activity was greater in patients infected by hbv genotype c than in those infected by hbv genotype b in the hbeag-positive phase but not after hbeag seroconversion. | 2003 | 12624067 |
| hepatitis b virus genotypes b and c do not affect the antiviral response to lamivudine. | to date, there have been no studies examining the role of hepatitis b virus (hbv) genotypes on the response to lamivudine therapy and the development of ymdd mutations. the present study aimed at determining any differences in the antiviral response and risk of ymdd mutations between lamivudine-treated patients with hbv genotype b and genotype c. eighty-two patients receiving lamivudine were recruited. hbv genotypes at baseline and ymdd mutations at week 52 were determined by line probe assays ( ... | 2003 | 14760886 |
| hepatitis b virus genotypes and hepatocellular carcinoma in japan. | hepatitis b virus (hbv) is one of the major causative agents of hepatocellular carcinoma (hcc) in southeast asia where hbv genotype b (hbv/b) and genotype c (hbv/c) are prevalent. clinical and virological differences were evaluated between hcc patients in japan and taiwan, all of whom were infected with hbv/b and hbv/c. in japan, the prevalence rates of hbv/b and hbv/c were 12 and 85%, respectively, in patients with chronic hbv infection, which is similar to those of 13 and 86% in patients with ... | 2003 | 14688460 |
| hepatitis b genotypes in chronic hepatitis b and lamivudine therapy. | the influence of hepatitis b virus (hbv) genotypes on the natural history and the response to treatment of patients with chronic hepatitis b are of potential interest. compared to the patients with hbv genotype c, those with genotype b were of a younger age and had a higher cumulative rate of hepatitis b e antigen (hbeag) seroconversion during the initial 6 years of follow-up. the earlier hbeag seroconversion in the patients with genotype b, however, did not provide them with a benefit in terms ... | 2003 | 14688455 |
| distribution of hepatitis b viral genotypes and mutations in the core promoter and precore regions in acute forms of liver disease in patients from chiba, japan. | although it has been reported that different hepatitis b virus (hbv) genotypes induce different clinical characteristics in patients with chronic liver diseases (cld), there have been few reports that have detailed the distribution of hbv genotypes in acute forms of liver disease. | 2003 | 14570734 |
| role of hepatitis b virus genotypes in chronic hepatitis b exacerbation. | hepatitis b virus (hbv) genotypes and precore and core promoter mutations were determined in 318 patients with hbv. patients infected with hbv genotype b had a higher median alanine aminotransferase level and bilirubin level and a lower median albumin level during exacerbations of disease, compared with patients infected with hbv genotype c (all p<.001). by logistic regression analysis, hbv genotype b infection (p=.014) and low albumin levels (p=.006) were independently associated with a higher ... | 2003 | 12905145 |
| influence of hepatitis b virus genotypes on the development of pres deletions and advanced liver disease. | hepatitis b virus (hbv) mutants with deletions in the pres region have not been evaluated for association with viral genotypes. in a case-control study, hbv dna samples collected from 80 each of carriers infected with hbv genotype b or c were examined for pres deletions. pres deletion mutants were found in a total of 37 of 160 (23%) hbv carriers. carriers with pres deletion mutants were older (56.0 +/- 12.7 vs 49.3 +/- 16.9 years, p < 0.05), were infected more frequently with hbv genotype c (84% ... | 2003 | 12794715 |
| genotype analysis, using pcr with type-specific primers, of hepatitis b virus isolates from patients coinfected with hepatitis delta virus genotype ii from miyako island, japan. | the aims of this study were to determine the hepatitis b virus (hbv) genotypes in hepatitis delta virus (hdv) rna-positive patients and to characterize the hbv nucleotide sequences that may be found on a distant island of japan. | 2003 | 12684550 |
| hepatitis b virus genotypes and spontaneous hepatitis b e antigen seroconversion in taiwanese hepatitis b carriers. | hepatitis b virus (hbv) is classified into eight genotypes (a-h), and genotype c is associated with more aggressive liver disease compared to genotype b. however, the mechanisms responsible for the clinical differences remain unclear. to test whether genotype c patients had with lower rates of spontaneous hepatitis b ge antigen (hbeag) seroconversion than genotype b patients, stored serum samples from 146 taiwanese adult hbeag-positive hepatitis b carriers followed-up for a mean of 52 months (ra ... | 2004 | 14748059 |
| clinical relevance of hepatitis b virus genotype in children with chronic infection and hepatocellular carcinoma. | the aim of this study was to investigate the influence of hepatitis b virus (hbv) genotypes on the clinical outcome of chronic childhood hbv infection and hepatocellular carcinoma (hcc). | 2004 | 15578511 |
| sustained response after a 2-year course of lamivudine treatment of hepatitis b e antigen-negative chronic hepatitis b. | lamivudine has demonstrated efficacy for the treatment of hepatitis b e antigen-negative chronic hepatitis b (e-chb). however, treatment withdrawal after 1 year has been associated with a high rate of relapse while long-term treatment is associated with increasing risks of drug resistance. we report our treatment experience of 50 chinese-canadian patients with e-chb. all patients received lamivudine for 2 years. treatment was withdrawn at month 24 in patients who had undetectable hepatitis b vir ... | 2004 | 15357648 |
| [effects comparison of lamivudine therapy for hepatitis b virus genotypes b and c]. | to determine the lamivudine response of hbv genotypes in patients with hbv dna positive chronic hepatitis. | 2004 | 15329211 |
| [establishing a new genotyping method of hepatitis b virus by polymerase chain reaction- restriction fragment length polymorphism (pcr-rflp) to analysis on s region and its application]. | to establish a new polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) method of genotyping hbv using mbo i, bstn i, bsma i, hpa ii and investigate the relationship between genotype and clinical spectrum of hepatitis b. | 2004 | 15329207 |
| [distribution of hepatitis b virus genotype in 5 cities of fujian province and the clinical implications of hbv genotype]. | to study the prevalence of hepatitis b virus (hbv) genotype in 5 cities of fujian province and the clinical implications of distinct genotypes in hbv-related liver diseases. | 2004 | 15200942 |
| two subtypes of genotype b (ba and bj) of hepatitis b virus in japan. | we have previously reported 2 subtypes of hepatitis b virus (hbv) genotype b, one of which has the recombination with genotype c over the precore region plus core gene (ba) and the other of which does not (bj). a restriction fragment-length polymorphism method with 2 endonucleases was newly developed for distinguishing between subtypes ba and bj and was applied to 313 carriers of hbv genotype b in japan. subtype ba was detected in 38 (12%) and subtype bj in 275 (88%) of the carriers of hbv genot ... | 2004 | 15127332 |
| genotypic dominance and novel recombinations in hbv genotype b and c co-infected intravenous drug users. | pathogenic differences among hepatitis b virus (hbv) genotypes have been documented. however, the interaction between different hbv genotypes remains unclear. herein, we chose hbv genotypes b (hbv/b) and c (hbv/c) co-infected intravenous drug users to study this issue. hbv genotype was determined in 40 hbsag, anti-hcv, and anti-hdv co-positive intravenous drug users by using genotype-specific primers. the distribution of hbv genotype was as follows: hbv genotype b alone in 29 (72.5%); hbv genoty ... | 2004 | 15042642 |
| clinical and virological differences between hepatitis b virus genotypes b and c: a case-control study. | the pathogenic significance of hepatitis b virus (hbv) genotypes is undefined. the aim of this study was to elucidate the differences in clinical and virologicalfeatures between hbv genotypes b and c by conducting a case-control study in thai patients who were chronically infected with the virus. | 2004 | 16083192 |
| hepatitis b virus core and core-related antigen quantitation in chinese patients with chronic genotype b and c hepatitis b virus infection. | hepatitis b virus (hbv) core-related antigen (hbcrag) and hbv core antigen (hbcag) assays were developed for the measurement of serum hbv load. the aim of this study was to assess the clinical utility of these assays in chinese patients with chronic genotype b and c hbv infection. | 2005 | 16246193 |
| lamivudine treatment in a patient with hepatitis b virus reactivation after allogenic peripheral bone marrow transplantation. | we report the case of a 52-year-old woman with hepatitis b virus (hbv) reactivation during treatment for chronic graft vs. host disease (gvhd) after peripheral bone marrow transplantation (pbsct) to treat chronic myelocytic leukemia. she was given cyclosporine and prednisolone orally to treat chronic gvhd after pbsct. liver dysfunction first developed 25 months after transplantation with the appearance of hepatitis b s antigen (hbsag), hepatitis b e antigen (hbeag), and elevation of hbv-dna up t ... | 2005 | 16019538 |
| peginterferon alfa-2a, lamivudine, and the combination for hbeag-positive chronic hepatitis b. | current treatments for chronic hepatitis b are suboptimal. in the search for improved therapies, we compared the efficacy and safety of pegylated interferon alfa plus lamivudine, pegylated interferon alfa without lamivudine, and lamivudine alone for the treatment of hepatitis b e antigen (hbeag)-positive chronic hepatitis b. | 2005 | 15987917 |
| virological differences between patients infected with subtypes ba and bj of hepatitis b virus genotype b. | hepatitis b virus (hbv) genotype b is classified into subtype ba with the recombination with genotype c in the precore region plus core gene and subtype bj without recombination. virological and clinical differences between infections with subtypes ba and bj, however, are yet to be determined. | 2005 | 15836705 |
| [genotyping of hepatitis b virus and its clinical significance in patients with chronic hepatitis b]. | to investigate the distribution of hepatitis b virus (hbv) genotypes in guangdong and explore its clinical significance. | 2005 | 15699014 |
| analysis of the entire nucleotide sequence of hepatitis b virus genotype b in the philippines reveals a new subgenotype of genotype b. | the entire nucleotide sequences were determined for hepatitis b virus (hbv) genotype b (hbv/b) genomes extracted from five patients in the philippines and designated genbank ab219426, ab219427, ab219428, ab219429 and ab219430. the serotype of the first four isolates was ayw and that of genbank ab219430 was adw. divergences of entire sequences were 1.0-2.0 % between the first four isolates and 3.8-4.2 % between these four and genbank ab219430. phylogenetic-tree analysis revealed that, worldwide, ... | 2006 | 16603518 |
| [identification of hepatitis b virus genotypes in patients with chronic hepatitis b from different nationalities in ethnic minority areas in yunnan province, china]. | to determine whether there is evolutionary difference in hepatitis b virus (hbv) genotypes among the patients with chronic hepatitis b (chb) of different nationalities and its clinical significance. | 2006 | 16681927 |
| nonresponse to 18-month lamivudine monotherapy in chronic hepatitis b patients with dual genotype b and c infection and acute exacerbation. | molecular epidemiologic studies have indicated the possible existence of mixed infection of different hepatitis b virus (hbv) genotypes in chronic hepatitis b (ch-b) carriers, but the effect of dual hbv genotype b and c infection on the efficacy of lamivudine therapy remains unclear. we report four ch-b patients with dual hbv genotype b and c infection and acute exacerbation who received lamivudine monotherapy for about 18 months. none of them had achieved a sustained response at the end of the ... | 2006 | 16877240 |
| molecular evolution of hepatitis b virus over 25 years. | determining the longitudinal molecular evolution of hepatitis b virus (hbv) is difficult due to hbv's genomic complexity and the need to study paired samples collected over long periods of time. in this study, serial samples were collected from eight hepatitis b virus e antigen-negative asymptomatic carriers of hbv genotype b in 1979 and 2004, thus providing a 25-year period to document the long-term molecular evolution of hbv. the rate, nature, and distribution of mutations that emerged over 25 ... | 2006 | 17041211 |
| [affects of hbv genotypes (b/c) on the levels of serum and intrahepatic hbsag]. | to observe the effects of hbv genotypes on the level of hbsag in serum and hepatocytes in chronic hepatitis b patients without antiviral therapy. | 2006 | 17064586 |
| association of human leukocyte antigen polymorphism with hepatitis b virus infection and genotypes. | associations were studied between the polymorphism of northern han chinese leukocyte antigen (hla) alleles and the outcomes of hepatitis b virus (hbv) infection and hbv genotypes. hla-a, b, and drb1 alleles in peripheral blood mononuclear cells (pbmcs) were detected by polymerase chain reaction (pcr) with sequence-specific primers. the pbmcs were collected from 61 persons who tested positive for hepatitis b surface antigen (hbsag) for more than 6 months (persistent group), 32 persons who tested ... | 2006 | 17186951 |
| genotype and variations in core promoter and pre-core regions are related to progression of disease in hbv-infected patients from northern vietnam. | vietnam is one of the countries with a high rate of hepatitis b virus (hbv) infection, but there are only a few reports about relation of hbv genotypes and mutations to clinical course in northern vietnam. the characteristics of hbv and its relationship to clinical outcome in patients from northern vietnam were analyzed. serum samples were collected from 183 hbv-infected vietnamese patients. they were clinically categorized into 4 groups: hepatocellular carcinoma (hcc), liver cirrhosis (lc), chr ... | 2007 | 17203204 |
| genotype b and younger patient age associated with better response to low-dose therapy: a trial with pegylated/nonpegylated interferon-alpha-2b for hepatitis b e antigen-positive patients with chronic hepatitis b in china. | cost and clinically significant adverse effects are the major limiting factors of interferon (ifn) use in therapy for chronic hepatitis b virus (hbv) infection. a clinical trial was conducted in china to study the efficiency and clinical relevance of low-dose regimen of ifn treatment for chronic hbv infection and to reveal factors predicting sustained combined response. | 2007 | 17243057 |
| [the relationships among hbv genotypes, hbv dna levels and histopathological features in the livers of familial grouped hepatitis b patients in the tianjin area]. | to analyse the relationships among hbv genotypes, hbv dna levels and histopathological features of the livers of familial grouped hepatitis b patients in the tianjin area. | 2007 | 17244452 |
| clinical and virological characteristics of hepatitis b virus subgenotypes ba, c1, and c2 in china. | hepatitis b virus (hbv) subgenotypes ba, c1 (cs), and c2 (ce) are the most prevalent hbv variants in china. to investigate the virological characteristics of these subgenotypes and their clinical implications, we enrolled a cohort of 211 patients in the guangdong province of china, including 132 with chronic hepatitis b virus infection (ch), 32 with liver cirrhosis (lc), and 47 with hepatocellular carcinoma (hcc) according to clinical examination, liver function test, and ultrasonograph results. ... | 2007 | 17376881 |
| polymorphism analyses of hepatitis b virus x gene in hepatocellular carcinoma patients from southern china. | chronic hepatitis b virus (hbv) infection is one of the major causes of hepatocellular carcinoma (hcc), and the hbv x (hbx) gene plays a critical role in the molecular pathogenesis of hbv-related hcc. we have investigated whether there are particular hbx gene mutations associated with hcc in patients from southern china. the hbx gene was examined in 51 paraffin-embedded tumor tissue samples from patients with hcc and 25 serum samples from the hbv carrier by nested polymerase chain reaction (pcr) ... | 2007 | 17417681 |
| detection of hepatitis b virus genotypes using oligonucleotide chip among hepatitis b virus carriers in eastern china. | to determine the genotype distribution of hepatitis b virus (hbv) with a newly oligonucleotide chip assay among the hbv carriers in eastern china. | 2007 | 17461500 |
| high prevalence of occult hepatitis b virus infection in taiwanese intravenous drug users. | the epidemiology and impact of occult hbv infection in intravenous drug users remain largely unknown. the aim of the study was to investigate the prevalence of occult hbv infection among intravenous drug users in taiwan. molecular assays were used to determine the level of serum hbv dna and the genotype in 304 intravenous drug users negative for both hbsag and anti-hcv. of 304 intravenous drug users, 125 (41.1%) were positive for serum hbv dna. the genotype distribution of hbv was as follows: b, ... | 2007 | 17854041 |
| clinical significance and evolution of core promoter and precore mutations in hbeag-positive patients with hbv genotype b and c: a longitudinal study. | the aims of this longitudinal study were to investigate whether the clinical outcome and evolution of core promoter and precore mutations were different during hepatitis b e antigen (hbeag) seroconversion between hepatitis b virus (hbv) genotypes b and c in hbeag-positive patients with chronic hepatitis b. | 2007 | 17617124 |
| [efficacy of adefovir dipivoxil was not related to genotypes b and c of hepatitis b virus: a randomized, double-blind, multicenter clinical study]. | to determine the relationship between the response to adefovir dipivoxil (adv) treatment in patients with hbv genotypes b and c of hbeag positive chronic hepatitis b. | 2007 | 17971947 |
| pre-s deletion and complex mutations of hepatitis b virus related to advanced liver disease in hbeag-negative patients. | this longitudinal study investigated the interactions and roles of hepatitis b virus (hbv) genotypes, pre-s deletions, and core promoter and precore mutations on the progression of liver disease in hepatitis b e antigen (hbeag)-negative patients. | 2007 | 17915220 |
| [comparison of bicyclol therapy for patients with genotype b and c of hepatitis b virus]. | to compare the efficacy of bicyclol tablets on patients infected with hepatitis b virus between genotype b and c. | 2007 | 18322605 |
| lower serum viral loads in young patients with hepatitis-b-virus-related hepatocellular carcinoma. | advanced age and high hepatitis b virus (hbv) dna level are risk factors associated with the development of hbv-related hepatocellular carcinoma (hcc). however, little is known about the role of viral load in the carcinogenesis of hcc in young people. a total of 183 hbv-related hcc patients and 202 hbv carriers were therefore enrolled to compare serum viral loads in young (</=40 years of age) and old (>40 years of age) age groups. other factors associated with the development of hcc were also an ... | 2007 | 17305880 |
| difference in t helper responses during hepatitis flares in hepatitis b e antigen (hbeag)-positive patients with genotypes b and c: implication for early hbeag seroconversion. | the underlying mechanisms for earlier hepatitis b e antigen (hbeag) seroconversion in patients with chronic hepatitis b virus (hbv) genotype b when compared with genotype c are unknown. we aimed to determine whether there were any differences in the t helper (th) responses during hepatitis flares in hbeag-positive patients with genotypes b and c. proliferative response measured by (3)h-thymidine uptake and th responses measured by enzyme-linked immunosorbent spot assays for interleukin (il)-2, i ... | 2007 | 17381719 |
| [the relationship between hbv genotypes and the efficacy of antiviral therapies in hepatitis b e antigen- positive patients]. | to study the relationship between hbv genotypes and the efficacy of antiviral therapies. | 2007 | 17594806 |
| association of pre-s deletion mutant of hepatitis b virus with risk of hepatocellular carcinoma. | pre-s deletion mutant of hepatitis b virus (hbv) affects the expression of middle and small surface proteins, resulting in intracellular accumulation of large surface protein. the correlation between pre-s deletion mutant and risk of hepatocellular carcinoma (hcc) in hepatitis b virus carriers remains unclear. | 2007 | 17608857 |
| differences of hbv genotypes and hepatocellular carcinoma in asian countries. | hepatitis b virus (hbv) genotype b (hbv b) and genotype c (hbv c) are prevalent in asia. recently hbv b has been classified into two subtypes, hbv ba, which is ubiquitous in asia, and hbv bj specific to japan. however, little is known about etiological, virological and clinical differences among patients who have various genotypes and who developed hepatocellular carcinoma (hcc). we investigated the relation of hbv subgenotype with etiological and clinical differences of hcc patients between tai ... | 2007 | 17627633 |
| [distribution of hepatitis b virus genotype b subgenotype in china]. | to investigate the distribution of hepatitis b virus (hbv) genotype b subgenotype in china. | 2007 | 17653307 |
| [relativity analysis of chronic hepatitis b virus genotype and clinical pathology]. | to explore the relationship between chronic hepatitis b virus genotypes and clinical pathology. | 2008 | 18574532 |
| [changes of serum hbsag in hbeag positive chronic hepatitis patients with sustained viral response to long-term lamivudine treatment]. | hbsag loss is rare in chronic hepatitis b patients, even in the patients with long-term nucleos(t)ide analogue therapy; therefore information about serum hbsag kinetics will be of value in understanding this unusual occurrence. | 2008 | 18578990 |
| associations between hepatitis b virus genotype and mutants and the risk of hepatocellular carcinoma. | the risk of hepatocellular carcinoma (hcc) increases with increasing level of hepatitis b virus (hbv) in serum (viral load). however, it is unclear whether genetic characteristics of hbv, including hbv genotype and specific genetic mutations, contribute to the risk of hcc. we examined the hcc risk associated with hbv genotypes and common variants in the precore and basal core promoter (bcp) regions. | 2008 | 18695135 |
| prevalence of hbv genotypes in central and eastern europe. | the importance of hepatitis b virus (hbv) genotypes for disease progression and response to interferon-alpha-based treatment is well established. while almost all patients in the mediterranean area are infected with hbv genotype d, hbv genotype a is dominant in northern europe. however, the distribution of hbv genotypes is unknown for several central and eastern european countries. data are described of 1313 hbsag-positive patients recruited at 14 referral centers in eight countries. there were ... | 2008 | 18712830 |
| hepatitis b virus genotype-associated variability in antiviral response to adefovir dipivoxil therapy in chinese han population. | it is well known that different genotypes of hepatitis b virus (hbv) have a different sensitivity to interferon-alpha or lamivudine (nucleoside analogue) antiviral therapy. however, for adefovir dipivoxil (adv, a nucleotide analogue), the antiviral response of the different genotypes remains to be clarified. in order to evaluate the response of hbv genotypes to adv therapy and to identify factors that might affect initial virological response, we performed a retrospective analysis on patients wi ... | 2008 | 18987454 |
| genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis b virus. | we aimed to identify genomic markers in hepatitis b virus (hbv) that are associated with hepatocellular carcinoma (hcc) development by comparing the complete genomic sequences of hbvs among patients with hcc and those without. one hundred patients with hbv-related hcc and 100 age-matched hbv-infected non-hcc patients (controls) were studied. hbv dna from serum was directly sequenced to study the whole viral genome. data mining and rule learning were employed to develop diagnostic algorithms. an ... | 2008 | 18216102 |
| high viral load and hepatitis b virus subgenotype ce are associated with increased risk of hepatocellular carcinoma. | we aimed to investigate the impact of hepatitis b virus (hbv) dna and hbv genotypes/subgenotypes on the risk of hepatocellular carcinoma (hcc). | 2008 | 18182659 |
| [study on relationship between hepatitis b virus dna load and genotype with large envelope protein]. | to explore the relation between hepatitis b virus dna load and genotype with the level of large envelope protein. | 2008 | 19469171 |
| [mutation of hepatitis b virus s gene in children with hepatitis b virus-associated glomerulonephritis]. | hepatitis b virus-associated glomerulonephritis (hbv-gn) is an immune complex-mediated glomerulonephritis. the present study was conducted to identify hbv s gene mutation in children with hbv-gn. | 2008 | 19099758 |
| [characteristics of hbcag(18-27) ctl epitopes of the main epidemic hbv strains in china]. | to study the characteristics of the virology background of hla-a2 restricted hbcag(18-27) epitope mutations in hbv infected patients in china. | 2008 | 18304422 |
| [analysis of the relevance of the mutations of the precore and basic core promoter in hbv genome with the dna amount of hbv viremia]. | in the course of hepatitis b, serum concentrations of the virus usually fall following sero-conversion, characterized by the loss of hbe antigen and appearance of detectable anti-hbe. however, hepatitis b viremia may persist even after sero-conversion. we assessed the association of continuous viremia with the precore (pc) (g1896a) mutation, basic core promoter (bcp) (a1762t, g1764a) mutations, the viral genotype and the quantity of viral dna. neither pc nor bcp mutations were detected in the vi ... | 2009 | 19489434 |
| associations between hepatitis b virus mutations and the risk of hepatocellular carcinoma: a meta-analysis. | the association between hepatitis b virus (hbv) mutations and hepatocarcinogenesis remains controversial because of conflicting data in the literature. we conducted a meta-analysis of case-control and cohort studies to examine hbv pres, enhancer ii (enhii), basal core promoter (bcp), and precore mutations in relation to the risk of hepatocellular carcinoma (hcc). | 2009 | 19574418 |
| prevalence of hepatitis b virus genotype b in vietnamese patients with chronic hepatitis b. | purpose: hepatitis b virus (hbv) genotypes can affect treatment response to interferon-based therapy and disease outcomes in patients with chronic hepatitis b (chb). little data exist to characterize hbv genotypes in vietnamese, one of the largest minority groups in the united states and also one with one of the highest chb and liver cancer disease burdens. the goal of this study was to compare the distribution of hbv genotypes in vietnamese and chinese patients. methods: we performed a cross-se ... | 2009 | 19669244 |
| hepatitis b virus subgenotypes and basal core promoter mutations in indonesia. | to identify the distribution of hepatitis b virus (hbv) subgenotype and basal core promoter (bcp) mutations among patients with hbv-associated liver disease in indonesia. | 2009 | 19705499 |
| comparison and significance of specific and non-specific cellular immunity in patients with chronic hepatitis b caused by infection with genotypes b or c of hepatitis b virus. | the present study was designed to investigate possible relationships between the genotypes of hepatitis b virus (hbv) and the hbv-specific cytotoxic t lymphocyte (ctl) responses. hbv genotypes, hbv specific ctl hbv dna and other markers of hbv infection were determined in 138 patients with chronic hepatitis b. the results showed that the patients infected with genotype c (n=62) had a significantly lower hbv-specific ctl response than those who were infected with hbv genotype b (p<0.01). hbv dna ... | 2009 | 19727589 |
| hepatitis b virus genotype b has an earlier emergence of lamivudine resistance than genotype c. | hepatitis b virus (hbv) genotype b and c seem not to affect the therapeutic response to lamivudine (3tc). whether a given genotype has an earlier emergence of 3tc resistance remains unclear. we thus conducted this study to elucidate the association of hbv genotype with the emergence of 3tc-resistant strains in taiwanese patients. | 2009 | 20032545 |
| [drug resistance, genotype, and serotype of hepatitis b virus in nucleos(t)ide analogue naive patients with chronic hepatitis b]. | to investigate drug resistance, genotype and serotype of hepatitis b virus (hbv) in nucleos(t)ide analogue (na) naive patients with chronic hepatitis b (chb). | 2010 | 20196945 |
| [c gene-targeting short hairpin rna suppresses the replication and expression of hepatitis b virus in bhk-21 cells]. | the vaccines currently developed against infectious diseases fail to induce effective antiviral immune responses to control an abrupt outbreak of viral diseases epidemic in a short space of time. hence there is an urgent need to develop emergency vaccines capable of producing prophylactic effects against infectious diseases. rna interference (rnai) is a mechanism that inhibits gene expression by causing the degradation of specific rna molecules or hindering the transcription of specific genes. t ... | 2010 | 21162917 |
| [association between hbv genotype and chronic/severe liver disease with hbv infection in chinese patients]. | to explore the association between hbv genotype and chronic/severe liver disease with hbv infection in chinese patients. | 2010 | 21186519 |
| distinct geographical and demographic distribution of hepatitis b virus genotypes in the canadian arctic as revealed through an extensive molecular epidemiological survey. | very little is known of hepatitis b virus (hbv) in canadian arctic indigenous populations, where hbv was considered endemic prior to the introduction of hbv vaccine. this study expands upon an hbv seroepidemiological survey conducted between 1983 and 1985 throughout the canadian arctic, to characterize hbv in this population. archived hepatitis b surface antigen (hbsag)-positive sera (n = 401) were processed for hbv dna, followed by sequencing and phylogenetic analysis of the hbsag- and hbcag-co ... | 2011 | 20723037 |
| hepatitis b virus genotype b results in better immediate, late and sustained responses to peginterferon-alfa in hepatitis-b-e-antigen-positive patients. | this study investigated outcome predictors in hepatitis-b-e-antigen (hbeag)-positive chronic hepatitis b patients treated with peginterferon alfa-2a. | 2011 | 21332543 |
| kaposi's sarcoma-associated herpesvirus infection in chinese patients with chronic hepatitis b. | the seroprevalence of kaposi's sarcoma-associated herpesvirus (kshv) in chinese patients with chronic hepatitis b, the relationship between kshv and hepatitis b virus (hbv) infection, and the influence of glycyrrhizic acid on kshv replication in vivo are undefined. plasma was collected from 211 patients with chronic hepatitis b. antibody to kshv orf65 was evaluated by elisa, and real-time pcr was used to quantify kshv dna and hbv dna. the kshv orf65 positivity rate in patients with chronic hepat ... | 2011 | 21360542 |
| serum hepatitis b surface antigen levels predict surface antigen loss in hepatitis b e antigen seroconverters. | loss of hepatitis b surface antigen (hbsag) usually indicates that hepatitis b virus (hbv) infection has been cured. however, little is known about factors predicting hbsag loss in patients who spontaneously clear hepatitis b e antigen (hbeag). | 2011 | 21672542 |
| low prevalence of hepatitis b virus pre-s deletion mutation in indonesia. | the molecular epidemiological study of hepatitis b virus (hbv) in indonesia is still limited. this study was aimed to identify the prevalence of hbv pre-s deletion/insertion mutations, and to assess the association of pre-s deletion mutation with liver disease progression in indonesia. pre-s mutations were identified by direct sequencing. of the 265 subjects, 32 samples (12.1%) harbored pre-s deletion/insertion mutations. the prevalence of those pre-s mutations was 2.7% (2/75), 12.9% (8/62), 16. ... | 2011 | 21837787 |
| Differential Clinical and Virologic Impact of Hepatitis B Virus Genotypes B and C on HIV-Coinfected Patients Receiving Lamivudine-Containing Highly Active Antiretroviral Therapy. | Background. The impact of hepatitis B virus (HBV) genotypes B and C on the clinical, immunologic, and virologic outcomes of human immunodeficiency virus (HIV)-infected patients with chronic HBV infection remains largely unknown.Methods. Between January 1997 and December 2008, we enrolled 96 HIV-infected patients with HBV genotype B coinfection and 49 with genotype C coinfection; the patients were followed prospectively until December 2010. Clinical and immunologic outcomes in the context of HBV ... | 2011 | 22156858 |
| [Distribution and clinical significance of HBV genotypes in patients with HBV infection in 30 regions of China]. | To explore the distribution and clinical significance of HBV genotypes in patients with HBV infection in China. | 2011 | 21863637 |
| a study of genotypes, mutants and nucleotide sequence of hepatitis b virus in pakistan: hbv genotypes in pakistan. | hepatitis b virus (hbv) genotypes and mutations are gaining importance in determining the clinical course of chronic liver disease. | 2011 | 22087110 |
| Prevalence of hepatitis B genotype and viral basic core promoter and precore mutations among teenagers in Macao: relationship with hepatocellular carcinoma development. | Chronic hepatitis B virus (HBV) infection is a global problem and over 75% of cases are reported in the Asia Pacific region. Infection can lead to progressive liver disease, cirrhosis and hepatocellular carcinoma (HCC). Previous studies suggest the prevalence of HBV carriers in Macau to be approximately 10% of the population. This study aims to investigate the prevalence of HBV genotypes among HBV-positive teenagers in Macao and the prevalence of base core promoter (BCP) and precore (PreC) mutat ... | 2011 | 21950207 |
| aboriginal taiwanese hepatitis b carriers have more favorable viral factors than han chinese carriers. | several viral factors are associated with disease progression in hepatitis b virus (hbv) carriers. compared with taiwanese han chinese, taiwanese aborigines have a higher prevalence of chronic hbv infection and a higher standardized mortality rate of chronic liver diseases but a lower standardized mortality rate of hepatocellular carcinoma (hcc). the aim of this study was to investigate whether aboriginal taiwanese hbv carriers have more favorable viral factors which reduce the risk for hcc than ... | 2011 | 21678436 |
| determinants of spontaneous surface antigen loss in hepatitis b e antigen-negative patients with a low viral load. | loss of hepatitis b surface antigen (hbsag) usually indicates the cure of hepatitis b virus (hbv) infection. in spontaneous hepatitis b e antigen (hbeag) seroconverters, lower serum hbsag and hbv dna levels have been shown to be associated with hbsag loss over time. however, little is known about their impacts on hbsag loss in hbeag-negative patients with limited viral replication. a total of 688 hbeag-negative patients with baseline serum hbv dna levels <2000 iu/ml were enrolled in taiwan. the ... | 2012 | 21858846 |
| Prevalence, virology and antiviral drugs susceptibility of hepatitis B virus rtN238H polymerase mutation from 1865 Chinese patients with chronic hepatitis B. | Amino acid substitutions at positions rtN238T/D of the hepatitis B virus (HBV) polymerase have been reported as potential mutations associated with adefovir (ADV) resistance. In this study, we characterized the prevalence of the rtN238H mutation and determined the susceptibility to LAM and ADV using phenotypic analyzes in vitro. One thousand eight hundred and sixty-five HBsAg-positive patients with chronic HBV (CHB) infection were included in this study. HBV genotypes and reverse transcriptase ( ... | 2012 | 22138714 |
| [mutation analysis of the hbv reverse transcriptase in nucleos(t)ide-treated patients with chronic hbv infection]. | to characterize genotypic resistance within hbv rt region in chronic hepatitis b (chb) patients with nucleos(t)ide analogue (na) treatment. | 2012 | 23627028 |
| fatty liver reduces hepatitis b virus replication in a genotype b hepatitis b virus transgenic mice model. | non-alcoholic fatty liver disease (nafld) overlapping with chronic hepatitis b virus (hbv) infection is undergoing a rapid increase in china. therefore, the establishment and character of an animal model with both nafld and chronic hbv infection has become an urgent task. | 2012 | 22989301 |
| [hepatitis b virus (hbv) mutation in enhancer i (hbv enh i)/x-promoter and the relationship between chronic hbv-related disease spectrum]. | to investigate the hepatitis b virus (hbv) mutation in the enhancer i (hbv enh i)/x-promoter and to analysis the relationship between chronic hbv-related disease spectrum. | 2012 | 22919746 |
| hepatitis b virus genotype b and high expression of interferon alpha receptor β subunit are associated with better response to pegylated interferon alpha 2a in chinese patients with chronic hepatitis b infection. | hepatitis b virus (hbv) is one of leading causes of various hepatic diseases including acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. hundreds of million people worldwide are infected by hbv, chronically. | 2012 | 22783345 |
| a type-specific nested pcr assay established and applied for investigation of hbv genotype and subgenotype in chinese patients with chronic hbv infection. | many studies have suggested that hepatitis b virus (hbv) genotypes show not only geographical distribution and race specificity, but also are associated with disease progression and response to interferon treatment. the objective of this study was to develop a nested polymerase chain reaction (npcr) assay for genotypes a-d and subgenotypes b1, b2, c1 and c2 of hepatitis b virus (hbv) and to investigate the distribution characteristics of hbv genotypes/subgenotype in china. | 2012 | 22716091 |
| correlation of the occurrence of ymdd mutations with hbv genotypes, hbv-dna levels, and hbeag status in chinese patients with chronic hepatitis b during lamivudine treatment. | continuous lamivudine therapy is associated with high rates of ymdd mutations, which are the main causes of drug resistance. the current study explores the association of the emergence of ymdd mutations with pretherapy hbv genotype, hbv-dna levels, hbeag status, and serum alanine aminotransferase (alt) levels in chinese patients receiving lamivudine therapy for chronic hepatitis b. | 2012 | 22484586 |
| the naturally occurring ymdd mutation among patients chronically infected hbv and untreated with lamivudine: a systematic review and meta-analysis. | several recent reports have demonstrated that tyrosine (y)-methionine (m)-aspartic acid (d)-aspartic acid (d) (ymdd) motif mutations can naturally occur in chronic hbv patients without antiviral treatment such as lamivudine therapy. this paper aims to assess the overall spontaneous incidence and related risk factors of ymdd-motif mutations among lamivudine-naïve chronic hbv carriers, so as to provide some clue for clinical treatment of hepatitis b. | 2012 | 22479339 |
| high levels of hepatitis b surface antigen increase risk of hepatocellular carcinoma in patients with low hbv load. | patients with chronic hepatitis b virus (hbv) infection have a high risk for developing hepatocellular carcinoma (hcc). patients with lower levels of hepatitis b surface antigen (hbsag) have higher chances of losing hbsag than those with high levels. however, little is known about whether higher levels of hbsag increase risk for hcc. | 2012 | 22333950 |
| predominance of precore mutations and clinical significance of basal core promoter mutations in chronic hepatitis b virus infection in indonesia. | chronic hepatitis b virus (hbv) infection is a major health problem worldwide, with a particularly high prevalence in the asian-pacific region. during chronic hepatitis b virus (hbv) infection, mutations commonly occur in the basal core promoter (bcp) and precore (pc) regions of hbv, affecting hbeag expression, particularly following hbeag serocon-version. mutations in the b- and t-cell epitopes of the hbv core have also been observed during disease progression. the clinical significance of hbv ... | 2013 | 24648979 |
| [effect of ptprd rs2279776 gene and interaction with hepatitis b virus mutations on the risk of hepatocellular carcinoma]. | to investigate the effect of rs2279776 at the ptprd and its interactions on hepatitis b virus (hbv)mutations as well as related risk on hepatocellular carcinoma (hcc). | 2013 | 24518026 |
| [functional analysis of hepatitis b virus immune escape mutants with insertion mutations in the surface antigen]. | to evaluate the influence of insertion mutations occurring in the hydrophobic region, between amino acids 114 and 115, of the hepatitis b surface antigen (hbsag) on viral antigenicity and replication. | 2013 | 24074709 |
| hepatitis b virus genotype c encoding resistance mutations that emerge during adefovir dipivoxil therapy: in vitro replication phenotype. | hepatitis b virus (hbv) can be classified into ten genotypes (a-j), with genotypes b and c being the most common in asia. recent data suggest that the hbv genotype can influence disease progression, and genotype c has been associated with more aggressive liver disease than that of other genotypes. although there is a preventative vaccine, chronic infection remains a public health problem with oral nucleos(t)ide analog therapy being the most common treatment. the hbv genome is composed of four pa ... | 2013 | 26201776 |
| relationship between hbv genotypes b, c and follicular helper t cells in patients with chronic hepatitis b and its significance. | clinical observations have shown that patients infected with chronic hepatitis b virus (hbv) genotype c versus genotype b had a higher load of the virus, more serious illness, and poorer responses to antiviral therapy and prognosis. however, the disparity between the two has not been clarified. | 2013 | 23585765 |
| longitudinal change of hbsag in hbeag-negative patients with genotype b or c infection. | quantitative hbsag has been recognized to assist in the management of chronic hepatitis b virus (hbv) infection. however, its role in disease monitoring of hbeag-negative patients remains unclear. we aimed to investigate the longitudinal hbsag change in hbeag-negative carriers with hbv genotype b or c infection. | 2013 | 23437072 |
| hepatitis b surface antigen serum level is associated with fibrosis severity in treatment-naïve, e antigen-positive patients. | little is currently known about the association between serum hbsag or hbv dna levels and the severity of liver disease in chronic hepatitis b (chb) patients. therefore, we investigated these relationships in a large cohort of unselected, well-characterized, treatment-naïve chb patients. | 2013 | 23369792 |
| distinct quasispecies characteristics and positive selection within precore/core gene in hepatitis b virus hbv associated acute-on-chronic liver failure. | the cause of hepatitis b virus associated acute-on-chronic liver failure (aclf) remains unclear. quasispecies can contribute to virus persistence and pathogenesis. we used a bioinformatics-based molecular evolution approach to compare quasispecies characteristics and positive selection sites within hbv precore/core gene between aclf and chronic hepatitis b (chb) patients. | 2013 | 23278564 |
| rates and risk factors for hepatitis b reactivation in a cohort of persons in the inactive phase of chronic hepatitis b-alaska, 2001-2010. | a high prevalence of reactivation of hepatitis b has been documented among immunosuppressed individuals in the inactive phase of chronic hepatitis b; however, the proportion of and the risk factors for reactivation are largely unknown among non-immunosuppressed persons. | 2013 | 24001884 |
| characterization of hepatitis b virus genotypes and quantitative hepatitis b surface antigen titres in north american tertiary referral liver centres. | hepatitis b virus (hbv) genotype and quantitative hepatitis b surface antigen (qhbsag) have been related to clinical outcome. in this nationwide cross-sectional study, we aimed to investigate the epidemiology and clinical significance of hbv genotype and qhbsag in patients with chronic hepatitis b (chb). | 2013 | 23763288 |