Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| a chinese insecticidal plant, tripterygium wilfordii, introduced into the united states. | 1941 | 17832851 | |
| triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from tripterygium wilfordii. | 1972 | 5072337 | |
| tripterygium wilfordii hook f in rheumatoid arthritis and ankylosing spondylitis. preliminary report. | 1981 | 6796344 | |
| tripterygium wilfordii hook f in systemic lupus erythematosus: report of 103 cases. | 1981 | 6800725 | |
| [clinical study of tripterygium wilfordii hook in treating glomerulonephritis (author's transl)]. | 1981 | 7307746 | |
| [studies on the chemical constituents of tripterygium wilfordii hook. ii. the structure of triptonolide, a new diterpenoid lactone (author's transl)]. | 1981 | 7304185 | |
| [clinical and experimental studies on the effect of tripterygium wilfordii hook in the treatment of nephritis]. | 1982 | 6817881 | |
| [studies on the chemical constituents of tripterygium wilfordii hook. f. iii. the isolation and structure of two new diterpenoid-lactones, triptophenolide methyl ether and neotriptophenolide (author's transl)]. | 1982 | 7102323 | |
| [clinical analysis of 31 cases of poisoning with tripterygium wilfordii hook. f., a chinese traditional herb medicine]. | 1982 | 7128303 | |
| clinical observation of 144 cases of rheumatoid arthritis treated with glycoside of radix tripterygium wilfordii. | 1983 | 6555445 | |
| clinical observations on tripterygium wilfordii in treatment of 26 cases of discoid lupus erythematosus. | 1983 | 6555446 | |
| [studies on pharmacological actions of total glycosides in tripterygium wilfordii]. | 1983 | 6226379 | |
| [toxicity of total glycosides in tripterygium wilfordii]. | 1983 | 6226402 | |
| cultivation of tripterygium wilfordii tissue cultures for the production of the cytotoxic diterpene tripdiolide. | the production of the cytotoxic agent tripdiolide employing plant tissue cultures of tripterygium wilfordii is demonstrated. detailed investigations of a developed cell line of t. wilfordii in terms of tripdiolide production versus variations in growth conditions, for example media composition, are presented. also the age and size of the inoculum and the incubation period with respect to tripdiolide formation are evaluated. | 1983 | 17404977 |
| studies on total glycosides of tripterygium wilfordii hook f in dermatoses. tripterygium wilfordii hook f research group. | 1984 | 6443299 | |
| effects of tripterygium wilfordii on the menstruation of 50 patients suffering from rheumatoid arthritis--with a summary of its therapeutic effects in 12 cases of menorrhagia. | 1984 | 6570157 | |
| an experimental pathological study of acute lei gong teng (tripterygium wilfordii hook) intoxication in rats. | 1984 | 6738988 | |
| [clinical analysis of 84 cases of glomerulonephritis treated with tripterygium wilfordii]. | 1984 | 6240328 | |
| [effect of tripterygium wilfordii on the remission of proteinuria in patients with nephrotic syndrome]. | 1985 | 3157498 | |
| [effects of total glycosides of tripterygium wilfordii on animal reproductive organs i. experiments of male rats]. | 1985 | 3158412 | |
| [effects of tripterygium wilfordii on rheumatoid arthritis--analysis of 165 cases]. | 1985 | 3159496 | |
| [studies on triterpenoids of tripterygium wilfordii hood-f]. | 1986 | 3811953 | |
| radix tripterygium wilfordii hook f in rheumatoid arthritis, ankylosing spondylitis and juvenile rheumatoid arthritis. | 1986 | 3098512 | |
| [a pentacyclic triterpene acid from tripterygium wilfordii]. | 1986 | 2946459 | |
| [effects of total glycosides of tripterygium wilfordii on the reproductive organs of experimental animals. iii. dynamic observations on the reproductive organs and fertility in mice]. | 1986 | 2943438 | |
| tripterygium wilfordii, a chinese herb effective in male fertility regulation. | a refined extract from the root xylem of tripterygium wilfordii hook. f. (the so-called multi-glycosides of the plant), available in the market as tablets for the long-term treatment of rheumatoid arthritis and various skin disorders, has recently been shown to possess a powerful antifertility effect in male rats and in men after oral administration at dose levels not showing apparent toxicity or side effects. fertility appears to be reversible after cessation of treatment. moreover, preliminary ... | 1987 | 3315438 |
| effect of tripterygium wilfordii on nephritis of anaphylactoid purpura. | 1987 | 3432251 | |
| [tripterygium wilfordii in the treatment of the nephritis of anaphylactoid purpura]. | 1987 | 2966011 | |
| [screening of active anti-inflammatory-immunosuppressive and antifertile compositions from tripterygium wilfordii. i. screening of 8 components from total glucosides of tripterygium wilfordii (tii)]. | 1987 | 2968853 | |
| [screening of active anti-inflammatory-immunosuppressive and antifertile components from tripterygium wilfordii. ii. screening of 5 monomers from total glucosides of tripterygium wilfordii (tii)]. | 1987 | 2968854 | |
| [the effect of combined use of gossypol and tripterygium wilfordii on the fertility of male rats]. | 1987 | 3452960 | |
| [tripterygium wilfordii on prolonging the survival time of myocardial allografts in mice]. | 1988 | 3289766 | |
| [studies on the chemical constituents of the stem and leaves of tripterygium wilfordii hook]. | 1988 | 3252988 | |
| [treatment of rheumatoid arthritis with tripterygium wilfordii hook. i. effect on secretion of total igm and igm-rf by peripheral blood mononuclear cells (pbmc)]. | 1988 | 2978257 | |
| [multiple sclerosis treated with tripterygium wilfordii tablets]. | 1988 | 2457453 | |
| future developments in contraception. | research in the improvement of current contraceptive methods includes the development of longacting, biodegradable steroid delivery systems; antiviral spermicides; and condoms made of better materials than latex rubber. at the forefront of research are the development of male contraceptive pills and contraceptive vaccines. progestagens cannot be used to suppress spermatogenesis without suppressing libido unless they are accompanied by replacement androgen therapy. moreover, it is extremely di ... | 1988 | 3217321 |
| structural elucidation of triptofordins f-1, f-2, f-3, and f-4, new sesquiterpenes polyesters from tripterygium wilfordii hook fil. var. regelii makino. | 1988 | 3246002 | |
| [summary on the clinical uses and study of tripterygium wilfordii]. | 1988 | 3061673 | |
| studies on new components and stereochemistry of diterpenoids from trypterygium wilfordii. | an extensive investigation of the petroleum ether extract of tripterygium wilfordii plants have revealed the presence of four new compounds, triptonoterpene, neotriptonoterpene, triptonodiol, and neotriptonolide, in addition to the diterpenes isolated and characterized earlier. the structures of these novel natural products have been elucidated. | 1988 | 17265278 |
| [cause of amenorrhea after treatment with tripterygium wilfordii f]. | fourteen female patients with rheumatoid arthritis who developed amenorrhea after treatment with t2 were investigated endocrinologically. fsh and lh levels began to rise after 2-3 mon and reached menopausal levels at 4-5 mon of treatment. e2 levels began to drop after 3-4 mon and reached very low levels at 5 mon of treatment. this indicates that the site of action of t2 is the ovary. the factors effecting amenorrhea may be related to dosage and the status of reproductive function. cytotoxicity m ... | 1989 | 2528424 |
| [studies on triterpenoids of total glucosides of tripterygium wilfordii (t ii)]. | five triterpenoids were isolated from total glucosides of tripterygium wilfordii (t ii). t1 was identified as wilforlide a; t2 a new triterpenic acid, as 3 beta-22 beta-dihydroxy-delta 12-oleanen-29-oic acid, named triptotriterpenic acid b; t6 as orthosphenic acid; t3 and t28 had been reported in other papers. t2, t6 and t28 have been further confirmed by x-ray analysis. all of them were shown to have anti-inflammatory action except t1 wasn't examined. | 1989 | 2534610 |
| [histopathologic observation on the therapeutic effect of tripterygium wilfordii in treating experimental allergic encephalomyelitis]. | the tripterygium wilfordii (tw) was used to treat experimental allergic encephalomyelitis (eae) in guinea-pig. the morphological change was observed by using light microscope. lymphocytic histochemical staining was performed on the spinal cord from eae in guinea-pig. the results were: the incidence of inflammatory reaction, neuraxial swelling, break and neuronal necrosis in the treatment group was lower than that in the control group (p less than 0.01-0.005); the variation of incidence of neurof ... | 1989 | 2786771 |
| [mechanism of treating rheumatoid arthritis with tripterygium wilfordii hook. ii. effect on pge2 secretion]. | pbmc from normal adults and patients with rheumatoid arthritis (ra) were cultured in the absence or presence of various concentrations of t2, indomethacin, dexamethasone for certain periods of time. the amounts of pge2 in the cell-free supernatants were measured by radioimmunoassay, and a significant reduction of pge2 production by pbmc cultured with 2-50 micrograms/ml of t2 was found. the percentages of inhibition of pge2 production in the cultures with 2 micrograms/ml, 10 micrograms/ml and 50 ... | 1989 | 2527628 |
| screening of 5 monomers from total glucosides of tripterygium wilfordii. | 1989 | 2594742 | |
| [immunosuppresive effects of wilfortrine and euonine]. | wifortrine and euonine isolated from tripterygium wilfordii hook. f. wilfortrine and euonine (40.80 mg/(kg.d) x 4d ip) showed marked depressant effects on humoral mediated immunity using the hemolysin reaction as indices. wilfortrine (160 mg/kg.d x 9d ip) exhibited a depressant effect on graft vs host reaction (gvhr), but wilfortrine (80 mg/(kg.d) x 9d ip) showed no definite effect. euonine (80 mg/(kg.d) x 10d ip) showed marked suppressant effects on dncb induced delayed hypersensitivity reactio ... | 1989 | 2618700 |
| [a tablet of tripterygium wilfordii in treating lupus erythematosus]. | twenty-three cases of lupus erythematosus, including 15 cases of sle and 8 cases of dle treated with tripterygium wilfordii (tw, three tablets thrice a day, each tablet contains 5 gm of crude tw) were reported. as controls, 19 cases of sle were treated with prednisone alone at the same time. 9/15 cases in the former group and 6/19 in the latter got improvement after treatment. there was no significant difference between the two groups (p greater than 0.10). however, tw had beneficial effects to ... | 1989 | 2791160 |
| effect of rhodamine 123 and total glycosides from tripterygium wilfordii (gtw) on ultrastructures, survival and fertilizing capacity of human sperm in vitro. | human sperms were treated with rhodamine 123 or gtw in vitro. comparisons were made of survival, fertilizing capacity and ultrastructures of sperms which had been exposed to different concentrations and treatment durations of the agents. the results showed that no prominent change could be observed when treated with lower doses. however, at higher concentrations of rhodamine 123, mitochondria were found to be swollen, vacuolated and deranged instead of surrounding the flagellar axoneme in the no ... | 1989 | 2798404 |
| [the isolation and structure identification of triptotriterpenic acid c]. | a new ursolic-type acid named triptotriterpenic acid c was obtained from the total glycosides extracted from the root of tripterygium wilfordii hook.f. its structure was inferred from chemical reaction, ir, 1hnmr, 13cnmr and ms spectral data. the structure and stereochemistry of this compound was confirmed to be 3 beta,22 alpha-dihydroxy-delta 12-ursene-30-oic acid by x-ray crystallo-diffraction analysis of its methyl ester. | 1989 | 2816380 |
| [mechanism of treating rheumatoid arthritis with polyglycosides of tripterygium wilfordii hook (t ii). iii. study on inhibitory effect of t ii on in vitro ig secreted by peripheral blood mononuclear cells from normal controls and ra patients]. | the in vitro effects of polyglycosides of tripterygium wilfordii hook (t ii) on immunoglobulin (ig) production by peripheral blood mononuclear cells (pb-mc) from seventeen healthy persons and eight rheumatoid arthritis (ra) patients were studied. pbmcs, monocytes and lymphocytes were treated separately with different doses of t ii for different periods of time. cells in different combinations were cultured for two weeks under pokeweed mitogen (pwm) stimulation and the igg and igm content of cult ... | 1990 | 2150359 |
| [comparative studies on antifertility mechanism and toxicology of tripterygium wilfordii monomer t4 and gossypol]. | inhibition of spermatogenesis and turnover of basic nuclear protein in late elongated spermatids of rat testis by tripterygium wilfordii monomer t4 was more obvious than that by gossypol. clustered positive deposits of gamma-gt, alp reaction were found in the inner edges of epididymal epithelium. head and tail separation, mid-piece coiling and axial fiber dislocation of epididymal spermatozoa in t4 treated rats were more obvious than those of gossypol-treated rats. mitochondrial ldh, ldh-x and m ... | 1990 | 2151263 |
| radix tripterygium wilfordii--a chinese herbal medicine with potent immunosuppressive properties. | radix tripterygium wilfordii hook-f (tw) is a chinese herbal medicine that has been reported to be effective in the treatment of various autoimmune disorders in experimental animals and man. little is known about the immunosuppressive mechanism of action of this medicine. we demonstrate herein that tw is capable of inhibiting several afferent immune functions including the in vitro response of human peripheral blood mononuclear cells to both mitogen and alloantigen, and the generation of cytotox ... | 1990 | 2368155 |
| [comparative clinical study of rheumatoid arthritis treated by triptolide and an ethyl acetate extract of tripterygium wilfordii]. | it was satisfactory using the ethyl acetate extract of tripterygium wilfordii (tw) to treat rheumatoid arthritis (ra). the results showed that the ethyl acetate extract of tw was the effective component part of tw. although the therapeutic effect of 15 cases with ra cured by triptolide was as effective as the ethyl acetate extract of tw, triptolide could impair some patients' hearts. this suggested that triptolide was one of the main effective elements of tw, but it was also one of the main toxi ... | 1990 | 2379295 |
| [effect of glycosides of tripterygium wilfordii hook on the reproductive system and major organs of male rats]. | spermatogenesis and turnover of basic nuclear protein synthesis in late elongated spermatids of rat testis were found to be significantly inhibited by glycosides of tripterygium wilfordii hook (t ii) at a daily dosage of 10 mg/kg for 7 or 13 weeks and 20 mg/kg for 4 or 10 weeks. the number of spermatozoa in the epididymis was found to be reduced and the remaining spermatozoa deformed, showing head swelling, head and tail separation and severe curling of the middle piece. these changes differed f ... | 1990 | 2150357 |
| [immunoregulatory effects of monomer t4 from tripterygium wilfordii hook. i. immunoregulatory effects of t4 on nk activity of mouse splenocytes]. | effects of monomer t4 on nk activity of mouse splenocytes were determined both in vitro and in vivo by means of a classical i-udr release assay. the results showed that monomer t4 exhibited dose-dependent double-regulatory inhibiting enhancing effects, ie, t4 of low dosage enhanced the percentage of nk cytotoxicity and lu numbers, while a high dosage showed dose-dependent inhibition. the double-regulatory effects of monomer t4 might be important for evaluation of the therapeutic effects of tript ... | 1990 | 2143110 |
| [structure revision of triptophenolide]. | a diterpenoid-lactone, white thin crystals, c20h24o3, m/z: 312 (m+), mp 222-223 degrees c, uv lambda max (etoh) 217 (log epsilon 4.36) nm, has been isolated from the ethyl acetate extract of the roots of tripterygium wilfordii hook. f., in a yield of 0.025%. its structure was elucidated by spectral analysis (uv, ir, ms, 1hnmr and 13cnmr) and x-ray scd. it is the known triptophenolide with revision of structure. triptophenlolide was shown to have obvious inhibiting effects on lymphocyte and igg ( ... | 1990 | 2104474 |
| [immunosuppressive and antiinflammatory activities of tripterine]. | tripterine is one of the active components isolated from tripterygium wilfordii hook.f. in this study tripterine was shown to inhibit the antibody response of mouse splenocytes to srbc both in vitro and in vivo either by primary or secondary stimulation. tripterine was also found to significantly inhibit cotton pellet induced granuloma growth in rats and depress the delayed hypersensitive reaction of mouse skin to dinitrochlorobenzene (dncb). besides, it also increased the sleeping time of mouse ... | 1990 | 2082679 |
| [the isolation and structure of tripchlorolide (t4) from tripterygium wilfordii]. | a new compound named tripchlorolide was isolated from total glucosides (t ii) extracted from the woody part of the root of tripterygium wilfordii hook. f. tripchlorolide (t4) was obtained as white needle-like crystals, mp 256-258 degrees c. its molecular formula is c20h25o6cl. the structure of t4 was elucidated on the basis of spectral (uv, ir, ms, ftms/sci, 1h-nmr, 13c-nmr, 1h-1h cosy, 13c-1h cosy) analyses, x-ray and chemical evidence. in preliminary pharmacologic assay, tripchlorolide showed ... | 1990 | 2150350 |
| [treatment of rheumatoid arthritis with low doses of multi-glycosides of tripterygium wilfordii]. | thirty two cases of rheumatoid arthritis were treated with multi-glycosides of tripterygium wilfordii (t2) in a dosage of 30 mg daily for 12 weeks. significant improvements in clinical and laboratory variables were observed. in comparison with the results of routine dose of t2 (60 mg per day) treatment, there was no significant difference to be seen between the two treatment plans. meanwhile, symptom of rash and slightly alimentary canal lower incidences and milder manifestations of side effects ... | 1990 | 2397546 |
| structure of tripterygic acid a: a new triterpene of tripterygium wilfordii. | from roots of tripterygium wilfordii used in chinese folk medicine, a new ursane-triterpene named tripterygic acid a was isolated along with a known triterpene and their structures were elucidated by means of spectral analysis and chemical transformation. | 1990 | 17221378 |
| growth and immobilization of tripterygium wilfordii cultured cells. | the plant tripterygium wilfordii produces di- and triterpenes of interest for male contraception and treatment of arthritis and skin disorders. cell line trp4a obtained form this plant in 1981 was reported to produce these valuable compounds at yields ( approximately 0.04% of the biomass dry weight) higher than found in the plant (0.001%). in order to improve this production, studies were carried out to determine the feasibility of eliminating the troublesome component of coconut milk originally ... | 1991 | 18600729 |
| immunomodulating chinese herbal medicines. | traditional chinese medicine always pays close attention to the strengthening of the patient's general resistance against illness, there are many chinese herbs used for thousands of years are considered as tonics. animal experiments and modern clinical trails have shown that quite a number herbs are immunologically active, and most of the tonics are excellent immunomodulating agents, such as polysaccharides or saponins isolated from astragalus mongholicus, acanthopanax senticosus and panax notog ... | 1991 | 1841992 |
| [antispermatogenic effects of multiglycosides of tripterygium wilfordii and monomer t4 in the testes and epididymal spermatozoa of rats]. | the antispermatogenic effects of the multiglycosides of tripterygium wilfordii (gtw) and monomer t4 isolated from gtw on the testes and epididymal spermatozoa of rats were examined microscopically following silver staining. the dosages of gtw and t4 were 10mg/kg.d and 0.05 mg/kg.d, respectively, fed for 7 weeks via gastric intubation. different degrees of damage to the testis and epididymal tubes were found in rats treated with gtw. deformed, round-headed sperms and exfoliated cells (mainly sper ... | 1991 | 1839514 |
| [summary of second national symposium of tripterygium wilfordii]. | 1991 | 1687966 | |
| [the structure of tripterygone]. | three triterpene compounds have been isolated from the roots of tripterygium wilfordii hook f. the structure of the new compound, 3-hydroxy-25-norfriedel-3, 1 (10)-dien-2-one-30 oic acid named tripterygone (iii), and the identity of others, 3 beta, 22 beta-dihydroxy-delta 12-oleanen-29-oic acid (i) and 2 alpha, 3 alpha, 24-trihydroxy-delta 12-ursene-28-oic acid (ii) have been established by spectral data and physical properties. compound ii was isolated for the first time from the title plant. | 1991 | 1957683 |
| development of male-fertility-regulating agents. | steroidal, nonsteroidal, plant-derived, gonadotropin-related and immunological agents investigated for control of male fertility are reviewed with brief descriptions of their effects, and illustrations of their structures. the physiology of the male reproductive system is presented as an introduction: an ideal male antifertility agent would inhibit spermatogenesis at the level of the sertoli cells, without affecting endogenous androgen production by leydig cells, needed for libido and potency. a ... | 1991 | 1943328 |
| effect of an extract of the chinese herbal remedy tripterygium wilfordii hook f on human immune responsiveness. | tripterygium wilfordii hook f (twh) is a vine-like plant that grows in a wide area of south china. an alcohol extract of this plant known as t2 has been suggested to be effective in the treatment of rheumatoid arthritis (ra). to examine the mechanism by which this herbal remedy might be effective in ra, the capacity of t2 to alter human immune responsiveness in vitro was investigated. human peripheral blood mononuclear cells were obtained from normal adults and separated into purified population ... | 1991 | 1930317 |
| some progress on the chemistry of natural bioactive terpenoids from chinese medicinal plants. | (1) pseudolaric acids--novel diterpenes, pseudolaric acid a, b, c and d were isolated from pseudolarix kaempferi gorden (pinaceae). their structures were assigned by spectroscopic data and chemical correlations. in the continuous studies, the absolute configurations, the conformations in the solutions, the fragmentation mechanisms of ms and assignments of all nmr spectral signals were also reported. they showed the antifungal and cytotoxic activities. (2)--daphnane diterpenes--in the further stu ... | 1991 | 1842005 |
| [inhibitory effect of tripterine on activities of il-1, il-2 and release of pge2]. | tripterine is one of the components isolated from tripterygium wilfordii hook. previous studies demonstrated that tripterine inhibited not only humoral and cellular immune responses but also some inflammatory responses. the present investigation attempted to observe effect of the drug on productions of il-1 from macrophages, il-2 from splenocytes and pge2 from synovial cells. the results showed that tripterine (0.1-1.0 microgram/ml) significantly inhibited il-1 activity of murine peritoneal macr ... | 1991 | 1821082 |
| can ethnopharmacology contribute to the development of anti-fertility drugs? | china, one of the developing countries with approx. one-fifth of the world population, has been making great efforts in controlling her population size. one of the efforts being stressed is to look into the practicability of employing chinese herbal medicine for fertility control. the rich ethnopharmacological descriptions in the ancient books of herbal remedy and those scattered in the folklore medicine contribute the possibility of this approach. after a discussion concerning the facets of ant ... | 1991 | 1881154 |
| [16-hydroxytriptolide, a new active diterpene isolated from tripterygium wilford ii]. | a new diterpene triepoxide, 16-hydroxytriptolide was isolated from the root and leaves of tripterygium wilfordii hook.f. 16-hydroxytriptolide was obtained as white cluster crystal, mp 232-233.5 degrees c. its molecular formula is c20h24o7. the structure and stereochemistry of 16-hydroxytriptolide was established as l2 on the basis of spectral data (ir, ms, uv, 1h-nmr, 13c-nmr, 2d-nmr, noe) and x-ray crystallographic analysis. in the pharmacologic screening, 16-hydroxytriptolide showed definite a ... | 1991 | 1823717 |
| inhibitory effect of triptolide on colony formation of breast and stomach cancer cell lines. | triptolide (tri) is a diterpenoid triepoxide isolated from tripterygium wilfordii hook f. the effects of tri on the colony formation of breast cancer cell lines mcf-7 and bt-20, stomach cancer cell lines mkn-45, mkn-7, and kato-iii, and promyelocytic leukemia cell line hl-60 were reported. using hamburger-salmon's double layer agar technique with certain modifications, cancer cells were cultured in 0.3% agar in a highly humidified atmosphere of 5% co2 at 37 degrees c for 14-21 d. colonies were c ... | 1991 | 1819894 |
| [screening of active anti-inflammatory, immunosuppressive and antifertility components from tripterygium wilfordii. iv. a comparison of the male antifertility activities of 7 diterpene lactone epoxide compounds]. | the male antifertility activities under equal toxic dosages 1/10-1/60 ld50 and hemolysin antibody formation parameters under effective threshold dosages respectively of 7 diterpene lactone epoxide compounds extracted from tripterygium wilfordii (tw) were assayed in mice. the results indicated that among the 7 compounds, 6 (t10, t4, t7, t8, t9 and l2) showed antifertility activities, the effective thresholds of t7, t8, t10 and l2 were below 1/40 ld50, those of t4 and t9 were below 1/60 ld50, whil ... | 1991 | 1838955 |
| [screening of active anti-inflammatory, immunosuppressive and antifertility components of tripterygium wilfordii. iii. a comparison of the antiinflammatory and immunosuppressive activities of 7 diterpene lactone epoxide compounds in vivo]. | the half-effective dose(ed50), therapeutic index(ti) and certain safety factor(csf) of 7 diterpene lactone epoxide compounds with antiinflammatory and immunosuppressive action extracted from tripterygium wilfordii (tw) were assayed using croton oil-induced ear swelling and hemolysin-antibody formation mouse models. the results indicated that triptolide(t10), tripchlorolide(t4), triptonide(t7), tripdiolide(t8), triptolidenol(t9) and 16-hydroxytriptolide(l2) possessed both anti-inflammatory and im ... | 1991 | 1838954 |
| prolonged survival of mrl-lpr/lpr mice treated with tripterygium wilfordii hook-f. | mrl-lpr/lpr mice were treated with tripterygium wilfordii hook-f (twhf), a chinese herbal medicine successfully used for human rheumatoid arthritis. dramatic prolongation of survival and the reduction of urinary protein were observed in mice treated with a high dose of twhf (20 mg/kg, three times a week) compared to the control animals receiving solvent alone. a slight but significant reduction was also seen in the degree of lymphadenopathy and arthritis with the high dose treatment. surprisingl ... | 1992 | 1728981 |
| [effects of gtw and t4 from tripterygium wilfordii hook f. on lh cells in male rat pituitary glands]. | using anti-beta-lh monoclonal antibodies, studies were undertaken to assess the effects of the glycosides (gtw) and t4 from tripterygium wilfordii hook f. on lh cells in male rat pituitary glands using immunohistochemical methods and ultrastructural observation. the results showed that there were more vacuoles in the cytoplasm of lh cells and the color density of immunohistochemical staining was much stronger in the treated groups than that in the control group. electron microscopic results show ... | 1992 | 1299539 |
| inhibitory effects of dihydroagarofuran sesquiterpenes on epstein-barr virus activation. | to search for possible antitumor promoters, we carried out a primary screening of thirty-seven dihydroagarofuran sesquiterpenes from tripterygium wilfordii hook fil. var. regelii makino and euonymus sieboldianus blume, using their possible inhibitory effects on the epstein-barr virus early antigen (ebv-ea) activation which is induced by 12-o-tetradecanoylphorbol-13-acetate (tpa) in raji cells. some of these sesquiterpenes, triptofordin f-2 (takaishi et al., 1988), 1,2,6,8,15-pentaacetoxy-9-benzo ... | 1992 | 1324784 |
| anti-aids agents, 4. tripterifordin, a novel anti-hiv principle from tripterygium wilfordii: isolation and structural elucidation. | a new kaurane-type diterpene lactone, tripterifordin [1], has been isolated from the roots of tripterygium wilfordii. the structure of 1 was elucidated by spectroscopic methods, including the concerted application of a number of 2d nmr techniques that involved the 1h-1h cosy, heteronucleus-detected variants of the heteronuclear chemical shift correlation (hetcor), phase-sensitive noesy, and long-range hetcor. compound 1 shows anti-hiv replication activity in h9 lymphocyte cells with an ec50 of 1 ... | 1992 | 1602302 |
| inhibition of type ii collagen induced arthritis in mice by an immunosuppressive extract of tripterygium wilfordii hook f. | the effects of tripterygium wilfordii hook f (twhf), a chinese herbal remedy, on type ii collagen induced arthritis (cia) in dba/1lacj mice were determined. mice were divided into 4 groups receiving oral treatment for 63 days: group a, sham feedings; group b, twhf (78 mg/day); group c, twhf (140 mg/day); group d, twhf (140 mg/day) starting 21 days after collagen immunization. arthritis incidence was reduced and day of onset delayed in groups b and c compared with a. arthritic joint counts, arthr ... | 1992 | 1613695 |
| effects of multiglycosides of tripterygium wilfordii (gtw) on rat fertility and leydig and sertoli cells. | primary cultures of rat leydig and sertoli cells were used to evaluate the direct effects of gtw on testicular cells and to compare these to the effects of gossypol acetate. both gtw and gossypol acetate can affect the survival of leydig and sertoli cells. but sertoli cells are much more sensitive than leydig cells, either to gossypol acetate or gtw. leydig and sertoli cells all died when they were exposed to gossypol acetate or gtw at a dose of 3.0 micrograms/ml or 30 micrograms/ml, respectivel ... | 1992 | 1511610 |
| [antitumor effect of tripterygium wilfordii]. | a new component of antitumor action tg has been isolated from the ethyl acetate extract of tripterygium wilfordii (besides triptolide, tripdiolide and triptonide). tg was shown in this study to have obvious antitumor effects. the average life span of h22, s180, eac and breast carcinoma-bearing mice treated with tg ip x 2 days were 100% more than those of the control mice (p less than 0.01) tg was able to inhibit tumor growth of s37-bearing mice at the dose of 150 mg/kg per day, ig x 3, its inhib ... | 1992 | 1504534 |
| the suspension culture of tripterygium wilfordii. | in suspension culturing of tripterygium wilfordii, 18.4 mg/l of dry cells and 9.184 mg/l of diterpene-lactone compounds were obtained from 6,7-v liquid medium containing 1 mg/l naa. besides those within the cells, diterpene-lactone compounds were also found in the cultured liquid and the yield reached 30.16-43.14% of the total yield. the total yield of diterpene-lactone compounds in suspension culture (6,7-v medium containing 1 mg/l naa) was 12.19 times as much as that in the roots of the origin ... | 1992 | 1457723 |
| suppression of renal disease and arthritis, and prolongation of survival in mrl-lpr mice treated with an extract of tripterygium wilfordii hook f. | treatment of mrl-lpr/lpr mice with tripterygium wilfordii hook f (twhf) to evaluate its effects on mortality, renal disease, and arthritis. | 1992 | 1445458 |
| [treatment of purpuric nephritis in children with tripterygium wilfordii and radix salviae miltiorrhizae]. | this paper dealt with the data of tripterygium wilfordii polyoglucoside (1 mg/kg.d) combined with radix salvaie multiorrhizae (6-15 g/d) for treating purpuric nephritis (group-a), compared with the control group of using tripterygium wilfordii polyoglucoside treatment only (group-b). the average time of edema-disappearing and blood pressure-resuming to normal range were 8.72 +/- 3.07 and 7.44 +/- 5.17 days in group-a, which were much better than those in group-b (p < 0.05). the average time of b ... | 1992 | 1421974 |
| anti-aids agents, 6. salaspermic acid, an anti-hiv principle from tripterygium wilfordii, and the structure-activity correlation with its related compounds. | salaspermic acid [1], an inhibitor of hiv reverse transcriptase and hiv replication in h9 lymphocyte cells, was isolated from the roots of tripterygium wilfordii for the first time. the structure of 1 derived from spectral data was established unequivocally by an x-ray analysis of crystals of the monohydrate. a structure-activity correlation of 1 with ten related compounds indicated that the acetal linkage in ring a and the carboxyl group in ring e of 1 may be required for the anti-hiv activity. | 1992 | 1375626 |
| [the effect of glycoside tripterygium wilfordii hook f on the immune regulatory function of t lymphocyte]. | previously, we treated successfully patients with systemic lupus erythromatosus (sle) with glycoside tripterygium wilfordii hook f, a chinese medicinal herb. to evaluate the pharmacological mechanism of this herb, we studied its effects on the activation and proliferation facets of human t lymphocyte in vitro. the results revealed that this drug can markedly suppress the activation and proliferation facets of t lymphocytes. | 1992 | 1363218 |
| the effect of multi-glycosides of tripterygium wilfordii hook f. (gtw) on the survival time of cardiac allografts in rats. | heterotopic heart transplantation was carried out in rats and the influence of multi-glycosides of tripterygium wilfordii hook f. (gtw) and a subtherapeutic dose of cyclosporine a (csa) on the mean survival time (mst) of the cardiac allografts was investigated. the results showed that the msts of cardiac allografts in both the gtw and csa-treated groups were significantly prolonged (p < 0.01 vs control). the rate of allograft rejection in the drug-treated groups was much lower than that in the c ... | 1992 | 1307500 |
| [structure modification of triptolide, a diterpenoid from tripterygium wilfordii]. | in this paper, the structure modification of triptolide was studied and nine triptolide derivatives were synthesized. a preliminary test for the immunosuppression activity in vitro showed that tripchlorolide (2) and tripbromolide (3) have strong activity similar to triptolide, while their toxicity are much lower. the activity of other compounds was decreased significantly. a simple method for the preparation of tripchlorolide from triptolide in 92% yield was found by reacting triptolide with hcl ... | 1992 | 1300027 |
| [the influence of chinese traditional medicine on the production and activity of interleukin 1 (il-1)]. | interleukin 1 (il-1) is a cytokine closely related to the pathogenesis of inflammation and chronic destructive changes in rheumatoid arthritis (ra). analysis of the effect of antirheumatic drugs on il-1 production and activity is of great importance in exploring the therapeutic mechanism of ra. the purpose of the present study was to investigate the effect of chinese herbs (10 prescription and 15 single drugs), which was often used in the treatment of ra, on the production and activity of il-1. ... | 1993 | 8131658 |
| inhibitory effects of triptogelin a-1 on 12-o-tetradecanoylphorbol-13- acetate-induced skin tumor promotion. | dihydroagarofuran sesquiterpenes, which were isolated from tripterygium wilfordii hook fil. var. regelii makino and euonymus sieboldianus blume, showed inhibitory effects on epstein-barr virus early antigen (ebv-ea) activation induced by 12-o-tetradecanoylphorbol-13-acetate (tpa). triptogelin a-1, one of the active dihydroagarofuran sesquiterpenes, exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. interestingly, triptogelin a-1 was ... | 1993 | 8383000 |
| the quest for a herbal contraceptive. | an oral herbal contraceptive would allow couples control their fertility without consulting a health worker, which in turn would likely markedly increase the number of couples practicing family planning. other advantages of such a contraceptive would include the familiarity rural people have with herbal medicines, the fewer side effects associated with herbal preparations, their ready availability from local sources, and protection of privacy. there are many references to plants in india with ... | 1993 | 8241931 |
| resolution of severe lupus nephritis associated with tripterygium wilfordii hook f ingestion. | 1993 | 8250996 | |
| [the suppressive effect of tripterygium wilfordii hook f on the il-2 autocrine loop of human t cells]. | we studied the effect of tripterygium wilfordii hook f on the il-2 autocrine loop of human t cells in vitro. the results revealed that gtw significantly inhibited the activation of t cells production of il-2, expression of il-2r and proliferation response of activated t cells exogenous il-2. | 1993 | 8222004 |
| effects of triptonide on mouse immune functions. | triptonide (tri) extracted from tripterygium wilfordii hook inhibited the proliferation of mouse splenocytes induced by suboptimal concentration of concanavalin a or lipopolysaccharide at concentrations of 0.02, 0.1, and 0.5 microgram.ml-1. it showed a suppressive effect on one way mixed lymphocyte culture (mlc) at 0.1-0.4 microgram.ml-1. the lymphocytes harvested from the first tri (0.4 microgram.ml-1)-containing mlc inhibited the second mlc after being washed and irradiated with 60co source (3 ... | 1993 | 8237400 |
| [immunosuppressive effect of tripterygium wilfordii and its application in transplantation]. | 1993 | 8257844 | |
| [rejection and tripterygium wilfordii treated small bowel allografts in pigs: pathological studies]. | segmental small bowel allografts in pigs were examined histologically to elucidate the rejection process. the specimens were obtained by biopsy at regular intervals after transplantation. early characteristics of acute rejection were marked by infiltration of mononuclear cells in the lamina propria. moderate rejection showed increased infiltrated mononuclear cells and mucosal lesions. mucosal necrosis occurred in the acute phase of rejection. rejection was seen in the animals that received only ... | 1993 | 8313198 |
| [studies on diterpenoids from leaves of tripterygium wilfordii]. | tripterygium wilfordii hook f. has been used as a medicinal herb in traditional chinese medicine and as an insecticide by the chinese for hundreds of years. recently, this plant has been used to treat cancer, rheumatic arthritis and various skin diseases in some chinese clinics. it is of interest to note that tripterygium also showed significant antifertility activities. the active principles of the anti-inflammatory, immunosuppressive and antifertile actions in tripterygium are diterpenoid cont ... | 1993 | 8328278 |
| an analysis of 24 patients with iga deposition at the bmz. | a study of 24 patients with iga deposition at the bmz of the skin showed that five conditions could be recognized: 1) linear iga bullous dermatosis in adults (lad, 7 cases); 2) linear iga and igg bullous dermatosis in adults (lagd, 10 cases); 3) chronic bullous disease of childhood (cbdc, 3 cases); 4) dermatitis herpetiformis (dh, 1 case), and 5) systemic lupus erythematosus (sle, 3 cases). histopathologically, 5 of 7 patients with lad were similar to the dh group, but 7 of 10 patients with lagd ... | 1993 | 8340531 |
| the hydroxylation of plant diterpene analogues by the fungus syncephalastrum racemosum. | triepoxide diterpenes isolated from the perennial herb, tripterygium wilfordii, have shown promising antileukemic and anti-inflammatory activity in vitro and in vivo. however, the toxicity of these epoxides has limited their clinical usefulness and analogues are sought which possess the pharmacological actions but have a lower toxicity. in this study, we have generated oxidized analogues of these diterpenes from a synthetic lactone precursor (19-hydroxy-18 (4-3) abeo-abieta-3,8,11,13-tetraen-18- ... | 1993 | 8489261 |
| male antifertility compounds from tripterygium wilfordii hook f. | extracts of the chinese medicinal plant, tripterygium wilfordii, cause reversible infertility in male animals. sub-fractionation studies have now revealed that the plant extracts contain a number of compounds which are potent antifertility agents in male mammals, including the diterpenes triptolide and tripdiolide and an isomer of the latter. a triptolide, 12,13-chlorohydrin, which is a transformation product formed reversibly by interaction of triptolide with hcl, was also found to be active. | 1993 | 8508668 |
| male fertility regulation: the challenges for the year 2000. | the search for new, safe, effective and reversible contraceptive methods for men is being pursued by several agencies. the most likely developments before the year 2000 would appear to be: the introduction of more easily reversed procedures of vas occlusion; hormonal means of sperm suppression based on infrequent injections of androgens either alone or combined with other gonadotrophin-suppressing agents. methods based on new drugs or vaccines are unlikely to be developed by the end of the decad ... | 1993 | 8324610 |