Publications

[phytochemical studies on lithospermum arvense l. (boraginaceae)].		1963	13979701
[androgenic and aphrodesiac action of the medicinal plant lithospermum arvense (bird millet)].	acute toxicity, androgenic, gonadotropic, estrogenic and aphrodisiac effect of the whole medical plant lithospermum aver arvense and its seeds was investigated on white rats and white mice. it was established that semen lithispermi arvense were nontoxic--ld50 in white rats and white mice was over 3000 mg/kg of body weight. the water extract of plant seeds, administered orally, in a dose of 300 mg/kg of body weight, had manifested aphodisiac and androgenic action. the obtained results are discuss ...	1989	2743927
[some evidence for the use of doctrine of signatures in the land of israel and its environs during the middle ages].	the doctrine of signatures, was developed in europe in the 16th and 17th centuries, though, its traces are spread until the present day in different traditional medicine cultures. this study traces the use of the doctrine of signatures in the medical and pharmacological literature of the land of israel and it's environs during the middle ages. the historical sources support the claim that although this theory did not originate in the region, it was certainly practiced there. these sources have r ...	2002	12187568
germination parameterization and development of an after-ripening thermal-time model for primary dormancy release of lithospermum arvense seeds.	models based on thermal-time approaches have been a useful tool for characterizing and predicting seed germination and dormancy release in relation to time and temperature. the aims of the present work were to evaluate the relative accuracy of different thermal-time approaches for the description of germination in lithospermum arvense and to develop an after-ripening thermal-time model for predicting seed dormancy release.	2009	19332426
a linear concatenation strategy to construct 5'-enriched amplified cdna libraries using multiple displacement amplification.	in various experimental systems, limiting available amounts of rna may prevent a researcher from performing large-scale analyses of gene transcripts. one way to circumvent this is to 'pre-amplify' the starting rna/cdna, so that sufficient amounts are available for any downstream analysis. in the present study, we report the development of a novel protocol for constructing amplified cdna libraries using the phi29 dna polymerase based multiple displacement amplification (mda) system. using as litt ...	2013	22941734
dietary omega-3 pufa and health: stearidonic acid-containing seed oils as effective and sustainable alternatives to traditional marine oils.	the daily consumption of dietary omega-3 pufa is recommended by governmental agencies in several countries and by a number of health organizations. the molecular mechanisms by which these dietary pufa affect health involve the enrichment of cellular membranes with long-chain 20- and 22-carbon omega-3 pufa that impacts tissues by altering membrane protein functions, cell signaling, and gene expression profiles. these changes are recognized to have health benefits in humans, especially relating to ...	2013	23417895
validation of endogenous reference genes in buglossoides arvensis for normalizing rt-qpcr-based gene expression data.	selection of a stably expressed reference gene (rg) is an important step for generating reliable and reproducible quantitative real-time reverse transcription polymerase chain reaction (rt-qpcr) gene expression data. we, in this study, have sought to validate rgs for buglossoides arvensis, a high nutraceutical value plant whose refined seed oil is entering the market under the commercial trade name ahiflower™. this weed plant has received attention for its natural ability to significantly accumu ...	2015	25918683
reintroduction of rare arable plants by seed transfer. what are the optimal sowing rates?	during the past decades, agro-biodiversity has markedly declined and some species are close to extinction in large parts of europe. reintroduction of rare arable plant species in suitable habitats could counteract this negative trend. the study investigates optimal sowing rates of three endangered species (legousia speculum-veneris (l.) chaix, consolida regalis gray, and lithospermum arvense l.), in terms of establishment success, seed production, and crop yield losses.a field experiment with pa ...	2016	27551400
consumption of buglossoides arvensis seed oil is safe and increases tissue long-chain n-3 fatty acid content more than flax seed oil - results of a phase i randomised clinical trial.	enrichment of tissues with ≥20-carbon n-3 pufa like epa is associated with positive cardiovascular outcomes. stearidonic acid (sda; 18 : 4n-3) and α-linolenic acid (ala; 18 : 3n-3) are plant-derived dietary n-3 pufa; however, direct comparisons of their impact on tissue n-3 pufa content are lacking. ahiflower(®) oil extracted from buglossoides arvensis seeds is the richest known non-genetically modified source of dietary sda. to investigate the safety and efficacy of dietary ahiflower oil, a par ...	2016	26793308
unravelling a stearidonic acid-rich triacylglycerol biosynthetic pathway in the developing seeds of buglossoides arvensis: a transcriptomic landscape.	buglossoides arvensis is an emerging oilseed crop that is rich in stearidonic acid (sda) and has several potential applications in human health and nutrition. the molecular basis of sda biosynthesis in this plant remains unknown due to lack of genomic information. to unravel key genes involved in sda-rich triacylglycerol (tag) biosynthesis, we performed transcriptome sequencing of pooled mrna from five different developmental stages of b. arvensis seeds using illumina nextseq platform. de novo t ...	2017	28874672
dietary buglossoides arvensis oil increases circulating n-3 polyunsaturated fatty acids in a dose-dependent manner and enhances lipopolysaccharide-stimulated whole blood interleukin-10-a randomized placebo-controlled trial.	buglossoides arvensis (ahiflower) oil is a dietary oil rich in stearidonic acid (20% sda; 18:4 n-3). the present randomized, double blind, placebo-controlled clinical trial investigated the effects of three ahiflower oil dosages on omega-3 polyunsaturated fatty acid (pufa) content of plasma and mononuclear cells (mcs) and of the highest ahiflower dosage on stimulated cytokine production in blood. healthy subjects (n = 88) consumed 9.7 ml per day for 28 days of 100% high oleic sunflower oil (hoso ...	2017	28287415