Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| serological divergence of dobrava and saaremaa hantaviruses: evidence for two distinct serotypes. | in order to investigate the serological relationship of dobrava hantavirus (dobv, originating from slovenia) and the dobrava-like saaremaa virus (saav, recently discovered in estonia) we analysed 37 human serum samples, 24 from estonia and 13 from the balkans, by focus reduction neutralization test (frnt). most of the estonian sera (19), including all sera from saaremaa island (12), reacted with higher frnt end-point titres to the local saav; the majority of them (15 and 11, respectively), with ... | 2002 | 11895097 |
| genetics of hantaviruses: implications to taxonomy. | hantaviruses (genus hantavirus, family bunyaviridae) represent a prime example of emerging viruses. since isolation of the prototype hantaan virus in the late 70s more than 20 new species have been described and the number is increasing fast thus demanding for a more refined classification. taking into account that hantaviruses are difficult to isolate in cell culture, one should not be surprised that most of the "newcomers" were first described as distinct hantavirus genotypes. moreover, the on ... | 2002 | 12038679 |
| hantavirus infections in latvia. | in order to investigate the presence of hantavirus infections in latvia, 333 randomly selected human serum samples were screened using an enzyme-linked immunoassay. fifteen samples were positive for hantavirus-specific igg and were subsequently serotyped using a focus reduction neutralization test. fourteen of these samples neutralized at least one of the hantaviruses included in the test, indicating a 4.2% overall seroprevalence in latvia. among 14 focus reduction neutralization test-positive s ... | 2002 | 12226698 |
| genetic characterization of new dobrava hantavirus isolate from greece. | the first complete genome sequence of dobrava hantavirus isolated from yellow-necked mouse apodemus flavicollis trapped in the northeastern greece is described. the s, m, and l segments of the greek isolate of dobrava virus are 1673, 3635, and 6532 nucleotides (nt) long, respectively, and encode the nucleocapsid (n) protein of 429 amino acids (aa), glycoprotein precursor of 1135 aa, and the l protein of 2151 aa. n protein contains three cysteine residues conserved in all known hantaviruses, as w ... | 2003 | 12526053 |
| hantavirus infections in spain: analysis of sera from the general population and from patients with pneumonia, renal disease and hepatitis. | hantaviruses are rodent borne viruses in the family bunyaviridae that cause significant morbidity in large areas of europe. there are only a few reports available on hantavirus infections from spain. although the results of these earlier studies indicated the presence of hantavirus infections, no confirmative or serotype-specific analyses have been performed. | 2003 | 12878094 |
| saaremaa hantavirus in denmark. | most human hantavirus infections in denmark have been registered on the fyn island with puumala hantavirus hosted by clethrionomys glareolus as the causative agent. to search for other known european hantaviruses in denmark, we analyzed 101 apodemus spp. mice trapped on the lolland island. genome sequences of saaremaa hantavirus (saav) were recovered from one of the a. agrarius, thus suggesting saav presence in denmark. we also analyzed serum samples from a patient from lolland with a history of ... | 2004 | 15135745 |
| phylogenetic evidence for the distinction of saaremaa and dobrava hantaviruses. | dobrava virus (dobv) and saaremaa virus (saav) are two closely related hantaviruses carried by different rodent species. the distinction of these two viruses has been a matter of debate. while the phylogenies based on the viral m segment sequences were repeatedly showing monophyly of saav strains, some trees based on the s segment sequences were not, thus causing questions on the demarcation between these two viruses. in order to clarify this issue, the current collection of the virus s segment ... | 2005 | 16336658 |
| dobrava, but not saaremaa, hantavirus is lethal and induces nitric oxide production in suckling mice. | hantaviruses are the causative agents of hfrs and hcps (hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome), two severe, and often fatal human diseases. mortality from hfrs varies between hantaviruses; hantaan and dobrava show the highest, seoul intermediate, and puumala low mortality. saaremaa, genetically closely related to dobrava, is also known to induce hfrs, with low or no mortality. in this study, mice were inoculated with dobrava and saaremaa viruses to test fo ... | 2006 | 16513381 |
| is there an association of pneumocystis infection with the presence of arena-, hanta-, and poxvirus antibodies in wild mice and shrews in finland? | as part of studies on the nature of the endemic virus infections in natural rodent hosts, the possible association of cyst forms of pneumocystis spp. with the presence of hanta-, cowpox-, and arenavirus antibodies in wild mice (apodemus flavicollis, n=105; apodemus agrarius, n=63; micromys minutus, n=50) and the common shrew (sorex araneus, n=101) was studied in south-central finland. one hantavirus (saaremaa virus, saav) seropositive a. agrarius, and 2 cowpoxvirus (cpxv) seropositive s. araneus ... | 2006 | 16556344 |
| saaremaa hantavirus should not be confused with its dangerous relative, dobrava virus. | 2006 | 16597913 | |
| serological survey for viral pathogens in turkish rodents. | wild rodents (n = 330) were trapped around the villages of altindere and coşandere (maçka, trabzon province), ayder, ortan, and yolkiyi (camlihemşin, rize province), and bozdag (odemiş, izmir province) in northeastern and western turkey during april 2004. samples were tested for arenavirus, hantavirus, and cowpox virus (family poxviridae, genus orthopoxvirus, cpxv) antibodies by using immunofluorescence assays (ifas). antibodies against arenaviruses were found in eight of 330 (2.4%) rodents. are ... | 2006 | 17092901 |
| characterization of hemorrhagic fever with renal syndrome caused by hantaviruses, estonia. | thirty cases of hemorrhagic fever with renal syndrome (hfrs) due to puumala virus (puuv), saaremaa virus (saav), and dobrava virus infection were confirmed in estonia. except for the levels of serum creatinine, no remarkable differences were found in the clinical course of hfrs caused by puuv and saav. | 2007 | 18217569 |
| [detection of anti-hantavirus antibodies in forest workers in the north-east of poland]. | to estimate exposition to hantaviruses in a high-risk population (forest workers) in the north-east of poland. | 2008 | 19108515 |
| the hantaviral load in tissues of naturally infected rodents. | hantaviruses cause a lifelong and asymptomatic infection in naturally infected hosts as well as in experimentally infected rodents. understanding the ecology and pathogenesis of hantaviruses requires an interdisciplinary research approach, which links laboratory experiments with results gained from field studies. although several studies report hantavirus persistence and tissue infection patterns for experimentally infected rodents, field data is very limited. for this reason, the aim of our stu ... | 2009 | 19397875 |
| co-circulation of three pathogenic hantaviruses: puumala, dobrava, and saaremaa in hungary. | hantaviruses (bunyaviridae) cause hemorrhagic fever with renal syndrome (hfrs) in eurasia and hantavirus (cardio)pulmonary syndrome (hcps) in the americas. hfrs is caused by hantaan virus (htnv), seoul virus (seov), dobrava virus (dobv), saaremaa virus (saav), and puumala virus (puuv). of those, only htnv is not present in europe. in recent years, hantaviruses, described in other parts of europe, were also detected at various locations in hungary. to study the genetic properties of hungarian han ... | 2009 | 19856478 |
| cross-species transmission in the speciation of the currently known murinae-associated hantaviruses. | to gain more insight into the phylogeny of dabieshan virus (dbsv), carried by niviventer confucianus and other murinae-associated hantaviruses, genome sequences of novel variants of dbsv were recovered from niviventer rats trapped in the mountainous areas of wenzhou, china. genetic analyses show that all known genetic variants of dbsv, including the ones identified in this study, are distinct from other murinae-associated hantaviruses. dbsv variants show geographic clustering and high intraspeci ... | 2012 | 22855492 |
| second external quality assurance study for the serological diagnosis of hantaviruses in europe. | hantaviruses are endemic throughout the world and hosted by rodents and insectivores. two human zoonoses, hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps), are caused by hantaviruses and case fatality rates have reached 12% for hfrs and 50% for hps in some outbreaks. symptomatic hantavirus infections in europe are summarised as hfrs mainly due to puumala, dobrava-belgrade and saaremaa virus. while hfrs has an overall low incidence in europe, the number of case ... | 2012 | 22509420 |
| genetic characterization of seoul hantavirus originated from norway rats (rattus norvegicus) captured in belgium. | hantaviruses (genus hantavirus, family bunyaviridae) cause hemorrhagic fever with renal syndrome (hfrs) in eurasia and hantavirus (cardio)pulmonary syndrome (hcps) in the americas. so far, in europe, four pathogenic hantaviruses have been found, often in co-circulation: puumala virus (puuv), dobrava virus (dobv), saaremaa virus (saav), and seoul virus (seov). of those, only puuv was found in belgium. recently, in our search for hantaviruses in the flanders region of belgium we collected genetic ... | 2012 | 22711359 |
| molecular characterization of dobrava and kurkino genotypes of dobrava-belgrade hantavirus detected in hungary and northern croatia. | among the hantavirus genus, saaremaa virus (saav) has been the subject of taxonomical debates. while the international committee on taxonomy of viruses declares saav as a distinct species, several european hantavirus experts proposed that saav is in fact a genotype of dobrava-belgrade virus (dobv). in the present study we performed s-segment-based phylogenetic analysis of eight dobv strains identified in rodents in hungary and northern croatia. these new sequences considerably increase the numbe ... | 2013 | 23896975 |
| dobrava virus carried by the yellow-necked field mouse apodemus flavicollis, causing hemorrhagic fever with renal syndrome in romania. | hemorrhagic fever with renal syndrome (hfrs) has been confirmed by serological methods during recent years in romania. in the present study, focus-reduction neutralization tests (frnt) confirmed dobrava hantavirus (dobv) as the causative agent in some hfrs cases, but could not distinguish between dobv and saaremaa virus (saav) infections in other cases. dobv was detected by a dobv-specific taqman assay in sera of nine patients out of 22 tested. partial sequences of the m genomic segment of dobv ... | 2014 | 24746107 |
| hantavirus infections. | over the past few decades understanding and recognition of hantavirus infection has greatly improved worldwide, but both the amplitude and the magnitude of hantavirus outbreaks have been increasing. several novel hantaviruses with unknown pathogenic potential have been identified in a variety of insectivore hosts. with the new hosts, new geographical distributions of hantaviruses have also been discovered and several new species were found in africa. hantavirus infection in humans can result in ... | 2015 | 24750436 |