Publications

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porcine adenovirus as a delivery system for swine vaccines and immunotherapeutics.porcine adenovirus (padv) has many qualities which make it an ideal choice for use as a delivery vector in swine. it is a low grade pathogen, present almost world-wide in a number of serotypes varying in their virulence and tissue tropism, which may allow for serotype specific vaccine targeting. padv is species specific having only been isolated from swine, reducing the possibility of its spread to other animals or man following administration. when engineered to contain a foreign gene, recombin ...200515683761
investigation of field outbreaks of turkey haemorrhagic enteritis in hungary.epidemiological, pathological, serological and virological investigations are reported on turkey haemorrhagic enteritis virus (thev) infection in hungarian turkey flocks. the pathogenesis of infection in experimentally infected turkeys and chickens, as well as the usefulness of polymerase chain reaction (pcr)/sequencing method for epidemiological investigation and for the differentiation of vaccine and field strains of thev was also studied. since the first recognition of the disease in hungary ...200717385563
confirmation of a novel siadenovirus species detected in raptors: partial sequence and phylogenetic analysis.partial genome characterisation of a novel adenovirus, found recently in organ samples of multiple species of dead birds of prey, was carried out by sequence analysis of pcr-amplified dna fragments. the virus, named as raptor adenovirus 1 (radv-1), has originally been detected by a nested pcr method with consensus primers targeting the adenoviral dna polymerase gene. phylogenetic analysis with the deduced amino acid sequence of the small pcr product has implied a new siadenovirus type present in ...200919061925
comparison of 12 turkey hemorrhagic enteritis virus isolates allows prediction of genetic factors affecting virulence.turkey hemorrhagic enteritis virus (thev) is a member of the genus siadenovirus and causes disease in turkey poults characterized by splenomegaly, bloody diarrhoea and death. the mechanism responsible for intestinal lesion formation and mortality is not known, although there is strong evidence that it is immune-mediated. all strains of thev are serologically indistinguishable, although there are naturally occurring avirulent strains of thev that replicate efficiently in turkeys without the intes ...200919386786
a novel budgerigar-adenovirus belonging to group ii avian adenovirus of siadenovirus.five budgerigars in the same breeding facility died or showed ruffled feathers. to determine the cause, five dead or euthanized budgerigars were examined. splenomegaly was observed at necropsy in all birds examined. histopathology of the spleen revealed a slight-to-moderate deletion of lymphocytes and increase of macrophages. concurrent congestions in several tissues such as liver, lung, kidney, and/or brain and basophilic intranuclear inclusion bodies in the epithelial cells of renal tubules we ...200919394371
systemic adenovirus infection in sulawesi tortoises (indotestudo forsteni) caused by a novel siadenovirus.a novel siadenovirus was identified in the sulawesi tortoise (indotestudo forsteni). a group of 105 sulawesi tortoises was obtained by the turtle survival alliance. many of the tortoises were in poor health. clinical signs included anorexia, lethargy, mucosal ulcerations and palatine erosions of the oral cavity, nasal and ocular discharge, and diarrhea. initial diagnostic tests included fecal testing for parasites, complete blood count and plasma biochemical analysis, mycoplasma serology, and po ...200919564489
siadenovirus infection in two psittacine bird species.consensus polymerase chain reaction was used to identify a novel adenovirus from two psittacine birds: a plum-headed parakeet (psittacula cyanocephala) with lethargy, weight loss, and marked leukocytosis; and an umbrella cockatoo (cacatua alba) with lethargy, weight loss, and feather abnormalities. phylogenetic and comparative sequence analysis suggested that this virus is a member of the genus siadenovirus, and is here termed psittacine adenovirus 2. this extends the characterized adenoviruses ...200919937528
recognition and partial genome characterization by non-specific dna amplification and pcr of a new siadenovirus species in a sample originating from parus major, a great tit.a seemingly novel siadenovirus species was detected by pcr and sequencing in the sample of a great tit (parus major) found dead in hungary. since the genus siadenovirus has very few known members so far, further study of the virus was intriguing not only from epizootiological but also from taxonomical aspects. the sample, which had been tested in another pcr survey previously, consisted of less than 50 microl of extracted nucleic acid. to ensure sufficient target dna for an extended study, the v ...201019854219
complete sequence of raptor adenovirus 1 confirms the characteristic genome organization of siadenoviruses.currently, the family adenoviridae contains five genera, out of which siadenovirus is one of the two least densely populated ones. a new member representing a new species in this genus has been detected in various birds of prey. the virus, named raptor adenovirus 1 (radv-1), could not be isolated, probably because no appropriate permissive cell-line was available. partial genomic sequences, obtained by pcr and suggesting that the virus is a new siadenovirus species, have been published earlier. ...201121463713
Full genome analysis of a novel adenovirus from the South Polar skua (Catharacta maccormicki) in Antarctica.Adenoviruses have been identified in humans and a wide range of vertebrate animals, but not previously from the polar region. Here, we report the entire 26,340-bp genome of a novel adenovirus, detected by PCR, in tissues of six of nine South Polar skuas (Catharacta maccormicki), collected in Lake King Sejong, King George Island, Antarctica, from 2007 to 2009. The DNA polymerase, penton base, hexon and fiber genes of the South Polar skua adenovirus (SPSAdV) exhibited 68.3%, 75.4%, 74.9% and 48.0% ...201222078165
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