Publications

monoamine oxidase inhibitor from the rhizomes of kaempferia galanga l.		1983	6652816
acetoxychavicol acetate, an antifungal component of alpinia galanga1.	the essential oils from fresh and dried rhizomes of alpinia galanga showed an antimicrobial activity against gram-positive bacteria, a yeast and some dermatophytes, using the agar overlay technique. the main components of the oils were also tested and terpinen-4-ol was found most active. an n-pentane/diethyl ether extract of dried rhizomes was active against trichophyton mentagrophytes. 1'-acetoxychavicol acetate, 1'-acetoxyeugenol acetate and 1'-hydroxychavicol acetate identified by ms and nmr ...	1985	17345272
screening for larvicidal activity of ten carminative plants.	ten species of plants, reported to possess carminative property, were screened for larvicidal potential against culex quinquefasciatus by exposing early 4th instar larvae to a series of concentrations of the ethanolic extracts of the plants. mortality counts were made after 24 hours exposure. probit analysis using computerized harvard programming (hg1, 2) was employed to determine the lc50, lc95 and lc99 values in order to compare the larvicidal potency of the ten plants. marked larvicidal effec ...	1998	10437975
amebicidal activity of plant extracts from southeast asia on acanthamoeba spp.	the effect of 100 polar and 100 nonpolar plant extract materials obtained from southeast asia were evaluated for amebicidal activity in vitro against three species of acanthamoeba. a. culbertsoni, a. castellanii, and a. polyphaga, the causative agents of granulomatous amebic encephalitis and amebic keratitis, were studied in vitro to determine whether the plant extracts exhibited amebicidal activity or induced encystment of the amebae. of the 200 plant extracts tested, extracts obtained from thr ...	1998	9766904
possible site of action of kaempferia galanga in killing culex quinquefasciatus larvae.		1999	10695810
anti-tumour promoter activity in malaysian ginger rhizobia used in traditional medicine.	zingiberaceae rhizomes commonly used in the malaysian traditional medicine were screened for anti-tumour promoter activity using the short-term assay of inhibition of 12-o-tetradecanoyl phorbol-13-acetate (tpa)-induced epstein-barr virus early antigen (ebv-ea) in raji cells. the inhibition of tpa-induced ebv-ea was detected using the indirect immunofluorescence assay (ifa) and western blot technique. the indirect ifa detected the expression/inhibition of ebv-ea-d (diffused ea antigen), whereas t ...	1999	10389986
larvicidal, adulticidal and repellent effects of kaempferia galanga.	four fractions of kaempferia galanga (hexane fraction, dichloromethane fraction 1, dichloromethane fraction 2 and methanolic fraction) were tested for larvicidal activity toward fourth instar culex quinquefasciatus. the hexane fraction was found to exhibit the highest larvicidal effect with the lc50 of 42.33 ppm. testing for adulticidal activity, the hexane fraction did not show any promising adulticidal effect. however, it caused a knockdown effect which might be useful as a repellent. it was t ...	1999	10774653
[study on the anti-carcinogenic effects of three compounds in kaempferia galanga l].	in order to study the anti-carcinogeneic effect of three compounds isolated from kaempferia galanga l, ebv assay, ear edema test, ornithine decarboxylase (odc) activity and two-stage-carcinogenisis test are applied. the results show that both -cis and -trans ethyl-p-methoxycinnamate has inhibitory effect in vitro, and also has inhibitory effects in tpa tests or croton oil-induced ear edema, odc activity in specimen of mouse epidermis and extent of papilloma, indicating a relatively strong anti-c ...	2002	12600030
vasorelaxant effects of ethyl cinnamate isolated from kaempferia galanga on smooth muscles of the rat aorta.	from the rhizomes of kaempferia galanga, ethyl cinnamate (ec) was isolated and its vasorelaxant effect was examined on the rat aorta. ec inhibited the tonic contractions induced by high k+ and phenylephrine (pe) in a concentration-dependent manner, with respective ic50 values of 0.30 +/- 0.05 mm and 0.38 +/- 0.04 mm. the relaxant effect against pe-induced contractions was greater in the presence of endothelium. pre-treatment of the aorta with methylene blue and indomethacin significantly reduced ...	2002	12143006
extracts of spice and food plants from thai traditional medicine inhibit the growth of the human carcinogen helicobacter pylori.	helicobacter pylori (hp) is a gramnegative bacterium and well recognized as being the primary etiological agent responsible for the development of gastritis, dyspepsia, peptic ulcer disease and gastric cancer. in developing countries, a high prevalence of hp infection is associated with an increased incidence of gastric cancer. thailand, however, while having a high prevalence of hp infections, has a lower than expected gastric cancer rate than other developing countries. it has been suggested t ...	2003	14758718
sulfur free radical reactivity with curcumin as reference for evaluating antioxidant properties of medicinal zingiberales.	rhizome extracts of some members of the medicinal zingiberales are widely used in dietary intake as well as in the traditional system of medicine. curcumin, the chrome orange-yellow coloring compound present in turmeric rhizomes, has long been known to possess antioxidant property. crude methanol extracts of the rhizomes of 11 species--alpinia allughas, a. galanga, curcuma amada, c. caesia, c. leucorrhiza, hedychium coronarium, h. coccineum, h. flavescens, kaempferia galanga, zingiber cassumunar ...	2004	15312045
toxicity of crude rhizome extract of kaempferia galanga l. (proh hom).	the ethanolic rhizome extract of kaempferia galanga l. (zingiberaceae) was studied by conventional pharmacological methods including the hippocratic screening test, and acute and subacute toxicities in rats. the hexane fraction was tested for dermal irritation in rabbits. the ethanolic extract, when tested by the hippocratic screening test, demonstrated signs that indicated cns depression such as a decrease in motor activity and respiratory rate, and a loss of screen grip and analgesia. in the a ...	2004	15013202
bioassay-guided isolation of a vasorelaxant active compound from kaempferia galanga l.	bioassay-guided fractionation was performed on a crude dichloromethane extract of kaempferia galanga l. using chromatography techniques. screening of the extract for biological activity started with the brine shrimp lethality bioassay, followed by the study of its antihypertensive activity on anaesthetized rats, which involved monitoring of the extract's effect on mean arterial blood pressure. the components of the fractions obtained from the separation procedures were analyzed using gas chromat ...	2006	16360934
wound healing activity of alcoholic extract of kaempferia galanga in wistar rats.	the wound healing effect of alcoholic extract of kaempferia galanga (k. galanga) and its effect in dexamethasone suppressed wound healing was studied in wistar rats. three wound models viz. incision, excision and dead space wounds were used in this study. the parameters studied were breaking strength in case of incision wounds, epithelialization and wound contraction in case of excision wound and granulation tissue dry weight, breaking strength and hydroxyproline content in case of dead space wo ...	2006	17402268
repellent activity of selected essential oils against aedes aegypti.	essential oils extracted from ten plant species were screened for repellency against aedes aegypti mosquitoes. three oils; zanthoxylum piperitum, anethum graveolens and kaempferia galanga, exerted protection against a. aegypti, with median complete-protection times of 1, 0.5 and 0.25 h, respectively. the protection times were increased significantly by incorporating 10% vanillin. the highest potential was established from z. piperitum oil +10% vanillin (2.5 h, range=1-2.5 h). mixtures from pairs ...	2007	17512681
anti-allergic activity of some selected plants in the zingiberaceae family.	ethanolic and water extracts, together with volatile oils from the rhizomes of six selected zingiberaceous plants, including curcuma mangga, kaempferia galanga, kaempferia parviflora, zingiber cassumunar, zingiber officinale and zingiber zerumbet were investigated for their anti-allergic activities using a rbl-2h3 cell line. the ethanolic (etoh) extract of kaempferia parviflora exhibited the most potent anti-allergic effect against antigen-induced beta-hexosaminidase release as a marker of degra ...	2007	16978816
antinociceptive activity of the methanolic extract of kaempferia galanga linn. in experimental animals.	kaempferia galanga linn. (zingiberaceae) presents many chemical constituents of the volatile oil extracted from the rhizome. the rhizome of kaempferia galanga is used by people in many regions for relieving toothache, abdominal pain, muscular swelling and rheumatism. in this study we investigated the antinociceptive activity in mice and rats using acetic acid-induced writhing, formalin, hot plate and tail-flick tests. the extract at test doses of 50, 100 and 200 mg/kg, p.o. clearly demonstrated ...	2008	18486374
antinociceptive and anti-inflammatory activities of the aqueous extract of kaempferia galanga leaves in animal models.	this study was performed to determine the antinociceptive and anti-inflammatory activities of aqueous extract of kaempferia galanga leaves using various animal models. the extract, in the doses of 30, 100, and 300 mg/kg, was prepared by soaking (1:10; w/v) the air-dried powdered leaves (40 g) in distilled water (dh(2)o) for 72 h and administered subcutaneously in mice/rats 30 min prior to the tests. the extract exhibited significant (p < 0.05) antinociceptive activity when assessed using the abd ...	2008	18404328
larvicidal activity of kaempferia galanga rhizome phenylpropanoids towards three mosquito species.	this study was aimed at assessing the toxicity of ethyl cinnamate and ethyl p-methoxycinnamate (emc) identified in kaempferia galangal l. (zingiberaceae) rhizome and another 12 known compounds to third-instar larvae from laboratory-reared culex pipiens pallens forskal, aedes aegypti l. and ochlerotatus togoi theobald and field-collected c. pipiens pallens (jinhae colony). results were compared with those for fenthion and temephos.	2008	18324612
sedative activity of hexane extract of keampferia galanga l. and its active compounds.	it is well known that fragrance impacts behaviors and autonomic functions, and is increasingly used as relaxant, carminative, as well as sedative in aromatherapy. kaempferia galanga l. is one of the popular traditional aromatic medicinal plants used in tropics and subtropics of asia including china, japan and indochina.	2008	18761077
chemical composition and larvicidal activity of edible plant-derived essential oils against the pyrethroid-susceptible and -resistant strains of aedes aegypti (diptera: culicidae).	the chemical compositions and larvicidal potential against mosquito vectors of selected essential oils obtained from five edible plants were investigated in this study. using a gc/ms, 24, 17, 20, 21, and 12 compounds were determined from essential oils of citrus hystrix, citrus reticulata, zingiber zerumbet, kaempferia galanga, and syzygium aromaticum, respectively. the principal constituents found in peel oil of c. hystrix were beta-pinene (22.54%) and d-limonene (22.03%), followed by terpinene ...	2010	20618656
antimicrobial and antioxidant activities of traditional thai herbal remedies for aphthous ulcers.	four medicinal plants (quercus infectoria, kaempferia galanga, coptis chinensis and glycyrrhiza uralensis) as well as one traditional thai treatment for aphthous ulcers based on these four plants were tested for antimicrobial activity. mic values for a range of bacteria and candida albicans were determined, with both type strains and clinical isolates being used. antioxidant activity was determined using the abts radical scavenging assay. among the four plants, q. infectoria showed antimicrobial ...	2010	20878703
supercritical carbon dioxide extraction of ethyl p-methoxycinnamate from kaempferia galanga l. rhizome and its apoptotic induction in human hepg2 cells.	in this study, supercritical carbon dioxide extraction of ethyl p-methoxycinnamate from kaempferia galanga l. rhizome and its apoptotic induction in human hepg2 cells are reported for the first time. by using supercritical carbon dioxide extraction, the yield of ethyl p-methoxycinnamate identified by gas chromatography mass spectrometry (gc-ms) was as high as 2.5% with respect to the raw materials. in the anticancer assay, it was found that ethyl p-methoxycinnamate could inhibit the proliferatio ...	2010	21108119
ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of mycobacterium tuberculosis in vitro.	many plants are used in ayurveda for the treatment of tuberculosis. our aim was to examine if these plants possess any specific molecule that inhibits mycobacterium tuberculosis. one of them, kaempferia galanga, yielded an anti-tb molecule, ethyl p-methoxycinnamate (epmc). by resazurin microtitre assay (rema), epmc was shown to inhibit m. tuberculosis h37ra, h37rv, drug susceptible and multidrug resistant (mdr) clinical isolates (mic 0.242-0.485mm). no cross resistance was observed to any standa ...	2011	21459133
antimalarial activities of medicinal plants and herbal formulations used in thai traditional medicine.	malaria is one of the world's leading killer infectious diseases with high incidence and morbidity. the problem of multidrug-resistant plasmodium falciparum has been aggravating particularly in southeast asia. therefore, development of new potential antimalarial drugs is urgently required. the present study aimed to investigate antimalarial activities of a total of 27 medicinal plants and 5 herbal formulations used in thai traditional medicine against chloroquine-resistant (k1) and chloroquine-s ...	2013	23340720
total phenolic compounds, flavonoids, and radical scavenging activity of 21 selected tropical plants.	free radical scavenging activity of 21 tropical plant extracts was evaluated using 1,1-diphenyl-2-picrylhydrazyl assay (dpph). total phenolic compounds and flavonoids were determined using folin-ciocalteu and hplc, respectively. results of the study revealed that all the plants tested exhibited excellent antioxidant activity with ic(50) in the range of 21.3 to 89.6 microg/ml. the most potent activity was demonstrated by cosmos caudatus (21.3 microg/ml) and piper betle (23.0 microg/ml) that are n ...	2014	20492146
combination effect of antituberculosis drugs and ethanolic extract of selected medicinal plants against multi-drug resistant mycobacterium tuberculosis isolates.	adverse drug reaction and resistance to antituberculosis drugs remain the causes of tuberculosis therapeutic failure. this research aimed to find the combination effect of standard antituberculosis drugs with hibiscus sabdariffa l., kaempferia galanga l., and piper crocatum n.e. br against multi-drug resistant (mdr) mycobacterium tuberculosis isolates. two mdr strains (i.e., isoniazid/ethambutol resistant and rifampicin/streptomycin resistant) of m. tuberculosis were inoculated in löwenstein-jen ...	2017	28335544
growth performance and feed utilization of keureling fish tor tambra (cyprinidae) fed formulated diet supplemented with enhanced probiotic.	background the objective of the present study was to determine the optimum dosage of probiotic in the diet of keureling fish ( tor tambra) fry. methodslactobacillus casei from yakult® was used as a starter, and enhanced with curcuma xanthorrhiza, kaempferia galanga and molasses. the mixture was fermented for 7 days prior to use as probiotic in a formulated diet containing 30% crude protein. four levels of probiotic dosage; 0 ml kg (-1) (control), 5 ml kg (-1), 10 ml kg (-1) and 15 ml kg (-1) wer ...	2017	28357045