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[summer-type hypersensitivity pneumonitis in a patient with a positive skin test (15 minutes) for trichosporon mucoides and a high serum ige level].the serum ige level is usually not high in hypersensitivity pneumonitis (hp) because it develops from type iii and type iv allergies (gell and coombs). however, we have previously reported infiltration of lymphocytes and mast cells in patients with summer-type hp and a high serum ige level. we encountered a 56-year-old woman with summer-type hp who had a high serum ige level and a positive skin reaction to the causative antigen. she was admitted to our hospital because of coughing, fever, and dy ...19968953916
[fungi and yeasts isolated in mycological studies in skin and nail infections in the netherlands, 1992-1993].to describe fungi and yeasts isolated from skin and nail infections in the netherlands.19968684495
[two patients with summer-type hypersensitivity pneumonitis in nagano prefecture].we encountered two patients with summer-type hypersensitivity pneumonitis that developed in nagano prefecture. patient 1 was a 61-year-old man who had worked in warm and humid environments as painter. he was referred to our hospital because of fever, coughing and exertional dyspnea. respiratory symptoms developed during work but were gone within in few weeks. patient 2 was a 50-year-old housewife who was admitted to our hospital because of persistent coughing and a low-grade fever. in both patie ...19979366171
isolation and characterization of a dibenzofuran-degrading yeast: identification of oxidation and ring cleavage products.we characterized the ability of a yeast to cleave the aromatic structure of the dioxin-like compound dibenzofuran. the yeast strain was isolated from a dioxin-contaminated soil sample and identified as trichosporon mucoides. during incubation of glucose-pregrown cells with dibenzofuran, six major metabolites were detected by high-performance liquid chromatography. the formation of four different monohydroxylated dibenzofurans was proven by comparison of analytical data (gas chromatography-mass s ...19989603837
effects of erythromycin on experimental extrinsic allergic alveolitis.recent clinical studies have demonstrated the efficacy of erythromycin for treating patients with chronic lower respiratory tract inflammation. mechanisms related to the anti-inflammatory action are yet to be determined.199910051731
hydroxylation of biphenyl by the yeast trichosporon mucoides.hydroxylation of biphenyl by the dibenzofuran-degrading yeast trichosporon mucoides sbug 801 was studied. glucose-grown cells degraded 40% of the biphenyl added within the first 24 h of incubation. the first step in the biotransformation pathway was the monohydroxylation of the biaryl compound to produce 2-, 3-, and 4-hydroxybiphenyl. further oxidation produced seven dihydroxylated intermediates; the second hydroxyl group was added either on the aromatic ring already hydroxylated or on the secon ...200011131026
experimental model of progressive disseminated trichosporonosis in mice with latent trichosporonemia.trichosporon asahii and trichosporon mucoides are the most common strains of fungi that cause disseminated trichosporonosis, a severe opportunistic infection in immunocompromised hosts. we have previously established a nested pcr assay using serum samples for detection of both strains. here we describe a new experimental animal model for investigating the underlying mechanisms of disseminated trichosporonosis. t. asahii (omu239, a clinical isolate from a patient with acute myelogenous leukemia) ...200010970368
[pathogenesis and treatment of hypersensitivity pneumonitis].hypersensitivity pneumonitis (hp) is a granulomatous interstitial lung disease resulting from an immunologic reaction to the repeated inhalation of organic dusts and active chemicals. there are 50 or more groups of hp, but the prevalence varies from country to country, and even within a country, depending on a variety of occupational or environmental inhalants. in western coutries farmer's lung, bird fancier's disease, humidifier lung, and air-conditioner disease are common, but in japan summer- ...200010938513
novel ring cleavage products in the biotransformation of biphenyl by the yeast trichosporon mucoides.the yeast trichosporon mucoides, grown on either glucose or phenol, was able to transform biphenyl into a variety of mono-, di-, and trihydroxylated derivatives hydroxylated on one or both aromatic rings. while some of these products accumulated in the supernatant as dead end products, the ortho-substituted dihydroxylated biphenyls were substrates for further oxidation and ring fission. these ring fission products were identified by high-performance liquid chromatography, gas chromatography-mass ...200111526019
oxidation of triphenylarsine to triphenylarsineoxide by trichoderma harzianum and other fungi.arsenic resistant strains of bacteria and fungi were isolated from soil contaminated by chemical warfare agents. until now, no metabolic products of microbial attack against the phenyl residues of the model substrate triphenylarsine (tp) were found if it was incubated together with these strains in liquid culture assays. however, one of the isolated fungi, trichoderma harzianum as 11, was found to oxidize tp to triphenylarsineoxide (tpo). the yeast trichosporon mucoides sbug 801 and the white-ro ...200111482658
[antifungal susceptibility of emerging yeast pathogens].to study the antifungal susceptibility of emerging yeast pathogens to know their possible resistance under the need of applying a treatment.200111440661
case reports. trichosporon mucoides infection in three premature newborns.in the present study trichosporon mucoides infections in 3 premature newborns are reported.200212000516
[pathogenesis of trichosporon asahii and strategies for infectious control of disseminated trichosporonosis].deep-seated trichosporonosis is a lethal opportunistic infection in immunocompromised patients. trichosporon asahii and t. mucoides are the most common strains of fungi that cause disseminated trichosporonosis. thirteen patients were diagnosed with disseminated trichosporonosis over a 20 year period in oita medical university hospital. the majority of them had underlying hematologic malignancies, for which they received cytotoxic chemotherapy resulting in neutropenia. for the rapid diagnosis of ...200312913806
ta-19, a novel protein antigen of trichosporon asahii, in summer-type hypersensitivity pneumonitis.the most common form of hypersensitivity pneumonitis in japan is summer-type hypersensitivity pneumonitis (shp), which is caused by the inhalation of trichosporon asahii or trichosporon mucoides. to seek protein antigens relevant to the immunopathogenesis of shp, we constructed a cdna expression library of t. asahii, a major causative yeast species of shp. using the immunoscreening method, we identified and cloned a novel gene encoding a 19-kd protein, named ta-19, which proved to be specificall ...200312493647
successful treatment of trichosporon mucoides infection with fluconazole in a heart and kidney transplant recipient.trichosporon species are an emerging cause of infection, particularly among transplant recipients. we report what we believe to be the first case of successful management of disseminated trichosporon mucoides infection with orally administered fluconazole in a heart and kidney transplant recipient.200312567323
cluster of trichosporon mucoides in children associated with a faulty bronchoscope.several outbreaks of pseudomonas aeruginosa infection associated with a specific model of fiberoptic bronchoscope have been reported. in a 3-week period in september 2000, we noticed an increased number of trichosporon mucoides isolates recovered from bronchoalveolar lavage (bal) specimens collected at our hospital. we investigated the circumstances surrounding these isolates.200312867835
invasive fungal infections in chile: a multicenter study of fungal prevalence and susceptibility during a 1-year period.during the first year of an ongoing surveillance program of invasive fungal infections (ifi) a total of 130 patients (56% male) with fungal strains isolated from blood and other sterile sites were reported from 13 hospitals in chile. significant yeast isolates were obtained from 118 patients, and molds affected 12 patients. the main patient groups affected were neonates, children less than 1 year old and adults aged 50-79 years. all fungal bloodstream infections (bsi) were due to yeasts; 79 pati ...200415473358
polyphasic identification of yeasts isolated from bark of cork oak during the manufacturing process of cork stoppers.a two-step protocol was used for the identification of 52 yeasts isolated from bark of cork oak at initial stages of the manufacturing process of cork stoppers. the first step in the identification was the separation of the isolates into groups by their physiological properties and rflps of the its-5.8s rrna gene. the second step was the sequencing of the d1/d2 domains of the 26s rrna gene of selected isolates representing the different groups. the results revealed a predominance of basidiomycet ...200415093778
in vitro interaction of micafungin with conventional and new antifungals against clinical isolates of trichosporon, sporobolomyces and rhodotorula.the infections caused by basidiomycetous yeasts are often difficult to resolve. combined therapy might be useful in those severe cases where a monotherapy was ineffective. the aim of this study was to evaluate the in vitro activity of combinations of micafungin with amphotericin b or fluconazole, itraconazole, voriconazole and ravuconazole against isolates of trichosporon, rhodotorula and sporobolomyces.200515845779
mycological examinations on the fungal flora of the chicken comb.a total of 500 combs of adult chickens from two different locations in germany (hessen and schleswig-holstein) were clinically and mycologically examined. the chickens came from three battery cages (n = 79), one voliere system (n=32), six flocks maintained on deep litter (n = 69) and 12 flocks kept on free outdoor range (n=320). twenty-two of the 500 chicken combs (4.4%) were found to have clinical signs: only non-specific lesions neither typical of mycosis nor of avian pox such as desquamation ...200515743428
yeast diversity in hypersaline habitats.thus far it has been considered that hypersaline natural brines which are subjected to extreme solar heating, do not contain non-melanized yeast populations. nevertheless we have isolated yeasts in eight different salterns worldwide, as well as from the dead sea, enriquillo lake (dominican republic) and the great salt lake (utah). among the isolates obtained from hypersaline waters, pichia guilliermondii, debaryomyces hansenii, yarrowia lipolytica and candida parapsilosis are known contaminants ...200515766773
in vitro susceptibility of yeasts isolated from patients in intensive care units to fluconazole and amphotericin b during a 3-year period.fungal infections have increased dramatically in recent years and candidemia is a major risk factor for morbidity and mortality in intensive care units (icus). candidemia has been considered to be a nosocomial infection that is strongly associated with neutropenia, recent surgery or presence of intravascular lines, and previous colonization is an independent risk factor. we evaluated the in vitro efficacy of fluconazole and amphotericin b against yeasts isolated from various clinical specimens o ...200515865609
[a familial case of summer-type hypersensitivity pneumonitis possibly associated with bird breeder's lung diagnosed by bronchoalveolar lavage fluid].case 1: a 32-year-old woman had cough and exertional dyspnea in august 2002, and chest computed tomographic scan revealed diffuse centrilobular nodules. bronchoalveolar lavage fluid (balf) showed a high proportion of lymphocytes with a decreased cd 4/cd 8 ratio. transbronchial lung biopsy (tblb) specimens showed alveolitis. summer-type hypersensitivity pneumonitis was diagnosed on the basis of positive findings of anti-trichosporon antibodies in the serum. case 2: a 64-year-old man, the father o ...200516366370
[trichosporon antibodies (corrected of antigen) and hla-antigen in summer-type hypersensitivity pneumonitis in a family].we encountered a family in which all of the three members (the parents, a 45-year-old woman and 51-year-old man, and their 15-year-old daughter) had trichosporon cutaneum antibodies (corrected of antigen), and two (the parents) suffered from summer-type hypersensitivity pneumonitis in the late summer. the husband complained of dry cough, fever and dyspnea on exertion from july after severe interstitial pneumonitis and was treated with steroid pulse in september 2004. his wife visited our hospita ...200516457336
oxidative ring cleavage of low chlorinated biphenyl derivatives by fungi leads to the formation of chlorinated lactone derivatives.the yeast trichosporon mucoides and the filamentous fungus paecilomyces lilacinus as biphenyl oxidizing organisms are able to oxidize chlorinated biphenyl derivatives. initial oxidation of derivatives chlorinated at c4 position started at the non-halogenated ring and went on up to ring cleavage. the products formed were mono- and dihydroxylated 4-chlorobiphenyls, muconic acid derivatives 2-hydroxy-4-(4-chlorophenyl)-muconic acid and 2-hydroxy-5-(4-chlorophenyl)-muconic acid as well as the corres ...200616352329
successful treatment of trichosporon mucoides infection with lipid complex amphotericin b and 5-fluorocytosine.infections in immunocompromised children can stem from bacteria, fungi, viruses, or protozoa, but most importantly, from the host's endogenous bacterial flora. disseminated infection caused by trichosporon species is one of the emerging mycoses in neutropenic patients, particularly when they are treated for haematological malignancy with cytotoxic and immunosuppressive chemotherapy. we report a 15-year-old boy with acute lymphoblastic leukaemia, whose trichosporon mucoides infection was successf ...200616681821
detection of pathogenic yeasts from processed fresh edible sea urchins sold in a fish market.yeasts of 17 processed fresh edible (raw) sea urchins obtained from seven countries were analyzed. in total, 45 to 7 x 10(4) colony-forming units (cfu)/g of sea urchins were recovered, and 23 yeast species were identified. of these species, six pathogenic yeasts (candida albicans, c. sake, debaryomyces hansenii, pichia anomala, rhodotorula mucilaginosa, and trichosporon mucoides) were detected from 11 sea urchins (65%). as these yeasts are opportunistic pathogens, infections in healthy individua ...200717975532
efficacy of chromogenic candida agar for isolation and presumptive identification of pathogenic yeast species.chromogenic candida agar is a novel differential culture medium that is claimed to facilitate isolation and identification of candida albicans, candida tropicalis and candida krusei. the performance of this medium was evaluated for presumptive identification of 521 yeast strains, representing 23 different species, for detection of specimens containing yeast mixtures, and for direct isolation of yeast from blood cultures. all yeasts grew well on the medium following a 48-h incubation period at 37 ...200817986267
isolation and characterization of new metschnikowia pulcherrima strains as producers of the antimicrobial pigment pulcherrimin.metschnikowia pulcherrima is a highly effective biocontrol yeast due to its pigment pulcherrimin that accumulates in the cells and in the growth medium. three different strains of m. pulcherrima were isolated from local grapes. the yeast isolates were characterized on the basis of their biochemical, physiological and its1-5.8 s rdna-its2 region. based on the obtained results, the m. pulcherrima isolates were identified as new strains of m. pulcherrima. strong antagonistic activities of the m. pu ...200919678547
prevalence of candida species in fresh fruit juices.fruit juices are popular soft drinks with an important role in human nutrition. fruit juices are often infested by yeast species that can survive different storage conditions. the aim of this study was to determine the degree of yeast contamination of freshly squeezed juices in three large supermarkets in zagreb, croatia. the analysis included 84 juice samples obtained from freshly squeezed orange, lemon, grapefruit, and apples. their acidity varied between ph 2.1 and ph 4.9. juice samples were ...200920061245
trichosporon mucoides fungemia in a liver transplant recipient: case report and review.four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus. during his hospitalization he experienced bloodstream infections including fungemia due to trichosporon mucoides and prolonged undulating fever despite antifungal and antibacterial treatment. he underwent removal of the allograft and implantation of another liver. fever continued postoperatively until therapy ...200918983414
identification of yeast isolated from dermatological patients by maldi-tof mass spectrometry.species identification of yeasts is based on biochemical (e.g. api id 32 c(®) , biomérieux) and molecular biological approaches. as an alternative to dna-dependent methods, mass spectral analysis based identification of micro-organisms has become increasingly recognized. in a number of studies, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) has been applied for the rapid classification and identification of micro-organisms. in this study, the applicab ...201121848605
onychomycosis due to trichosporon mucoides. 201121220891
identification of fungal dna in balf from patients with home-related hypersensitivity pneumonitis.background: in japan, a major type of home-related hypersensitivity pneumonitis (hp) is summer-type hp, which is caused by trichosporon asahii (t. asahii) or trichosporonmucoides. some patients with home-related hp test negative for antibodies against trichosporon; yet, a causative mold antigen cannot be identified. methods: we analyzed 19 patients with home-related hp, 8 healthy volunteers, and 35 patients with other diseases. we extracted dna from cell pellets of bronchoalveolar lavage fluid ( ...201121824758
evaluation of the acetone and aqueous extracts of mature stem bark of sclerocarya birrea for antioxidant and antimicrobial properties.we assayed the antimicrobial activity of acetone and aqueous extracts of the stem bark of sclerocarya birrea on some selected bacteria and fungi species including; streptococcus pyogenes, plesiomonas shigelloides, aeromonas hydrophila, salmonella typhimurium, cryptococcus neoformans, candida glabrata, trichosporon mucoides, and candida krusei using both agar well diffusion and minimum inhibitory concentration (mic) assays. based on the levels of activity, the acetone extract was examined for tot ...201222675390
photodynamic inactivation of biofilms formed by candida spp., trichosporon mucoides, and kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29h, 31h-phthalocyanine (znpc).the biofilms formed by opportunistic yeasts serve as a persistent reservoir of infection and impair the treatment of fungal diseases. the aim of this study was to evaluate photodynamic inactivation (pdi) of biofilms formed by candida spp. and the emerging pathogens trichosporon mucoides and kodamaea ohmeri by a cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29h,31h-phthalocyanine (znpc). biofilms formed by yeasts after 48 h in the bottom of 96-well microtiter plates were treated wi ...201222278349
[an overview on trichosporon asahii and its infections].trichosporon species cause systemic, mucosa associated and superficial infections which include white piedra. disseminated fungal infections due to trichosporon species have increased in the recent years. hematologic malignancy, cytotoxic chemotherapy, and organ transplantation are the main risk factors for disseminated trichosporon infections. two most common species that cause the disseminated trichosporon infections are trichosporon asahii and trichosporon mucoides. diagnosis and treatment of ...201223188586
antifungal susceptibility of emerging opportunistic yeasts and yeast-like fungi from rhea americana.opportunistic yeasts and yeast-like fungi have been recognized as important pathogens in high-risk patients. this study aimed to evaluate the presence of these microorganisms in the microbiota of captive rheas and to investigate the antifungal susceptibility of the isolated strains. isolates representing magnusiomyces capitatus (geotrichum capitatum, n = 11), trichosporon mucoides (n = 11), trichosporon asteroides (n = 5), rhodotorula mucilaginosa (n = 4), trichosporon asahii (n = 3), trichospor ...201323899001
novel insights into the fungal oxidation of monoaromatic and biarylic environmental pollutants by characterization of two new ring cleavage enzymes.the phenol-degrading yeast trichosporon mucoides can oxidize and detoxify biarylic environmental pollutants such as dibenzofuran, diphenyl ether and biphenyl by ring cleavage. the degradation pathways are well investigated, but the enzymes involved are not. the high similarity of hydroxylated biphenyl derivatives and phenol raised the question if the enzymes of the phenol degradation are involved in ring cleavage or whether specific enzymes are necessary. purification of enzymes from t. mucoides ...201323400446
use of the vitek 2 system to identify and test the antifungal susceptibility of clinically relevant yeast species.eleven quality control isolates (candida albicans atcc 64548, c. tropicalis atcc 200956, c. glabrata atcc 90030, c. lusitaniae atcc 200951, c. parapsilosis atcc 22019, c. krusei atcc 6258, c. dubliniensis atcc 6330, saccharomyces cerevisiae atcc 9763, cryptococcus neoformans atcc 90012, c. gattii fiocruz-cpf 60, and trichosporon mucoides atcc 204094) and 32 bloodstream isolates, including c. albicans, c. tropicalis, c. parapsilosis, c. glabrata, c. krusei, c. guilliermondii, c. pelliculosa (pich ...201324688520
oral colonization by yeasts in hiv-positive patients in brazil.in hiv-infected patients, colonization of the oral cavity by potential pathogenic yeast may lead to development of systemic fungemia. we evaluated the prevalence of yeast in the oral cavity of brazilian hiv-positive patients and verified whether or not the species characterized were enzymatically active. furthermore, the species identified were tested for their susceptibility to antifungal treatment.201322370749
development of multiplex loop-mediated isothermal amplification assays to detect medically important yeasts in dairy products.rapid detection of yeast contamination is important in the food industry. we have developed loop-mediated isothermal amplification (lamp) assays to detect the emerging opportunistic pathogenic yeasts: candida albicans, candida glabrata, candida tropicalis, the candida parapsilosis group, trichosporon asahii, and trichosporon mucoides. these yeasts may cause deep-seated candidiasis or trichosporonosis. four lamp primer sets specific for candida were designed to target the internal transcribed spa ...201424965944
escmid and ecmm joint clinical guidelines for the diagnosis and management of rare invasive yeast infections.the mortality associated with invasive fungal infections remains high with that involving rare yeast pathogens other than candida being no exception. this is in part due to the severe underlying conditions typically predisposing patients to these healthcare-related infections (most often severe neutropenia in patients with haematological malignancies), and in part due to the often challenging intrinsic susceptibility pattern of the pathogens that potentially leads to delayed appropriate antifung ...201424102785
fungemia due to trichosporon mucoides in a diabetes mellitus patient: a rare case report.trichosporon species are widely distributed in nature and can occasionally belong to the human microbiota. for many years, trichosporon beigelii, the only species of this genus, was found as the aetiological agent of superficial skin infection called white piedra. however, many cases of invasive trichosporonosis caused by different newly delineated species of trichosporon have been published in increasing numbers in recent past years, especially in immunocompromised persons. we report a rare cas ...201424399394
trichosporon inkin and trichosporon mucoides as unusual causes of white piedra of scalp hair.white piedra of scalp hair is considered a rare entity. we report three cases of this disorder all of whom presented with nodules on the hair. potassium hydroxide preparations of the hair revealed clustered arthrospores and mature, easily detachable nodules. cultures grew trichosporon inkin in 2 patients and trichosporon mucoides in one patient. both these fungi are unusual causes of white piedra.201425035357
characterization of the medically important yeast trichosporon mucoides and its close sister trichosporon dermatis by traditional and advanced technologies.trichosporon dermatis is a causative agent of several mycoses in immunocompromised patients but is often misidentified as trichosporon mucoides due to their phenotypic resemblance. in order to evaluate the current identification keys for these species and to develop a rapid and reliable identification method, 11 strains of these yeasts were fully characterized in this study by traditional and advanced technologies. dna sequences of the internal transcribed spacer (its), igs1, and d1/d2 regions i ...201526296931
trichosporon mucoides causing onychomycosis in an immunocompetent patient. 201524134663
trichosporon mucoides peritonitis in a continuous ambulatory peritoneal dialysis patient. 201523660618
molecular characterisation and antifungal susceptibility of clinical trichosporon isolates in india.in asian countries, trichosporon infection is a well-known disease in japan. in india, the infection is increasingly recognised. the study was conducted to characterise the clinical trichosporon isolates from india by phenotypic and molecular techniques. a total of 31 trichosporon clinical isolates, recovered from patients of 14 hospitals across india were sequenced (its and igs1 regions of rdna). in vitro drug susceptibility testing of the isolates was performed against amphotericin-b, fluconaz ...201627144725
onychomycosis caused by trichosporon mucoides.a case of onychomycosis caused by trichosporon mucoides in a man with diabetes is presented. the infection was characterized by a brown-black pigmentation of the nail plates and subungual hyperkeratosis of the first three toes of both feet. onychogryphosis was also visible on the third left toe. direct microscopic examinations revealed wide and septate hyphae and spores. three cultures on sabouraud-gentamicin-chloramphenicol 2 agar and chromid candida agar produced white, creamy, and smooth colo ...201626603646
investigations of kanuka and manuka essential oils for in vitro treatment of disease and cellular inflammation caused by infectious microorganisms.diseases caused by infectious and inflammatory microorganisms are among the most common and most severe nosocomial diseases worldwide. therefore, developing effective agents for treating these illnesses is critical. in this study, essential oils from two tea tree species, kanuka (kunzea ericoides) and manuka (leptospermum scoparium), were evaluated for use in treating diseases and inflammation caused by microorganism infection.201624582465
sequencer-based capillary gel electrophoresis (scge) targeting the rdna internal transcribed spacer (its) regions for accurate identification of clinically important yeast species.accurate species identification of candida, cryptococcus, trichosporon and other yeast pathogens is important for clinical management. in the present study, we developed and evaluated a yeast species identification scheme by determining the rdna internal transcribed spacer (its) region length types (lts) using a sequencer-based capillary gel electrophoresis (scge) approach. a total of 156 yeast isolates encompassing 32 species were first used to establish a reference scge its lt database. evalua ...201627105313
pigeons and their droppings as reservoirs of candida and other zoonotic yeasts.the importance of pigeons as reservoirs and carriers of cryptococcus neoformans and other species of this genus is well-known; however, less is known about their role as reservoirs and carriers of other yeasts that impact public health.201728720316
comparative evaluation of six chromogenic media for presumptive yeast identification.the present study was undertaken to evaluate the discrimination ability of six chromogenic media in presumptive yeast identification.201728663328
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