Publications

anopheles nf-κb-regulated splicing factors direct pathogen-specific repertoires of the hypervariable pattern recognition receptor agdscam.	insects rely on innate immune responses controlled by the immune deficiency (imd), toll, and other immune signaling pathways to combat infection by a broad spectrum of pathogens. these pathways signal to downstream nf-κb family transcription factors that control specific antipathogen action via direct transcriptional control of immune effectors, hematopoiesis, and melanization. here we show that in the anopheles malaria vector, imd and toll pathways mediate species-specific defenses against plas ...	0	23084919
[extraction of precipitating insulin antibodies from the goat, caper domesticus].		1969	4182169
further new diterpene esters from the irritant and cocarcinogenic seed oil and latex of the caper spurge (euphorbia lathyris l.).		1971	5144835
[on constituents of caper-spurge seed (lathyridis seed). i. isolation and reactions of epoxylathyrol (author's transl)].		1973	4797477
computers in behavioral science. a comprehensive automated psychological examination and report (caper).		1973	4146026
contact dermatitis from plants of the caper family, capparidaceae. effects on the skin of some plants which yield isothiocyanates.		1974	4851166
the presidential prize caper.		1974	17756749
on the active principles of the spurge family. iii. skin irritant and cocarcinogenic factors from the caper spurge.	the toxic and irritant principles of the seed oil and of the latex of the caper spurge (euphorbia lathyris l.) were isolated together with several non irritants of similar chemical structure. from the seed oil two irritant euphorbia factors l5 and l6 and from the latex a mixture of irritant euphorbia factors were obtained. euphorbia factor l5 was identified as 3-hexadecanoate of the new tetracyclic, poly-functional diterpene parent alcohol ingenol. euphorbia factor l6 most probably is the 3-tetr ...	1975	128221
computer-assisted pathology encoding and reporting system (caper).	an on-line computer-assisted pathology encoding and reportying system (caper) has been developed by the department of pathology and laboratory of computer science of the massachusetts general hospital for a department of surgical pathology that processes more than 25,000 specimens yearly. caper performs clerical functions, including the accessioning of specimens, monitoring their state of completion, production of log books, billing, statistics, and transfer of diagnoses to other hospital depart ...	1977	602910
cloning caper makes it to the halls of congress.		1978	17738709
cathy's policy caper.		1978	248873
the notorious decontamination caper.		1979	388632
retrieval in a computer-assisted pathology encoding and reporting system (caper).	a previous report described an online computer-assisted pathology encoding and reporting system (caper) developed at the massachusetts general hospital that accessions specimens, monitors their state of completion, produces all log books, and permits instantaneous display of all diagnoses rendered within a three-year period. the present report updates the functions currently available and describes a new function that enables the pathologist, independent of computer programmer support, to reques ...	1981	6786087
the great crystal caper: chemists debate whether it makes scientific sense to try to grow macromolecular crystals in space.		1985	17795890
isolation and characterization of glucocapparin inisomeris arborea nutt.	isomeris arborea (capparaceae), is the only woody caper endemic to southern california and northern baja. methylglucosinolate, also known as glucocapparin, was the only glucosinolate found ini. arborea organs by paper chromatography of the thiourea derivatives and was quantitatively determined by gas chromatography by hydrolytic products. the concentration of glucocapparin ranged from an average of 4.6 mg/g wet weight in mature leaves to 5.2 mg/g wet weight in immature leaves. buds averaged 6.2 ...	1986	24307123
the computer caper.		1986	3638953
anti-inflammatory activity of some saudi arabian medicinal plants.	five plants which have been used for the treatment of rheumatism, arthritis and gout in the traditional medicine of saudi arabia, were evaluated for their anti-inflammatory properties. of these the ethanolic extract of capparis decidua and the aqueous extract of capparis spinosa were found to possess significant anti-inflammatory activity against carrageenan induced oedema in rats. these two plants were also tested for their antipyretic and analgesic activity. c. decidua was found to possess sig ...	1986	3485894
the community that cares caper.		1987	10283268
isolation and identification of an anti-inflammatory principle from capparis spinosa.	the homologous polyprenols cappaprenol-12 (1), cappaprenol-13 (2) and cappaprenol-14 (3) with 12, 13 and 14 isoprene units, respectively, could be isolated by preparative hplc from alcoholic extracts of capparis spinosa. testing 2 for its anti-inflammatory activity an inhibition of the carrageenan-induced paw edema in rats of 44 vs. 67% for the standard oxyphenbutazone was found.	1988	3244735
capsid caper in cable. xiith international conference on bacteriophage assembly, cable, wi, usa, june 11-16, 1991.		1991	1777479
allergic contact dermatitis from capparis spinosa l. applied as wet compresses.		1991	1893693
paper caper.		1991	18796834
mortality of leishmania major in phlebotomus papatasi caused by plant feeding of the sand flies.	the plant feeding of phlebotomus papatasi and the effects of plant diets on the leishmania major infections were investigated. plant-fed flies had small free particles and membranous shreds in their gut that were stained by calcofluor as cellulosic plant tissues. they were found in 34.0% of the female and 14.3% of the male sand flies following feeding on the caper plant (capparis spinosa). no plant residues were found in 54 females that had been fed on plant-derived honeydew secretions of aphis ...	1994	8304569
canadian anaesthesia physician resource planning--is it possible?	this study was undertaken with the objective of assessing current sources of information for anaesthesia physician resource planning (prp). four major data bases, the annual reports of health and welfare canada (h&w), the education statistics from the canadian post-m.d. education registry (caper), the royal college of physicians and surgeons of canada (rcpsc) and the physician resource data system of the canadian medical association (prds), were examined for the period 1982 to 1991. the ratio of ...	1995	7788834
creamed corn caper baffles multi-service provider.		1996	10159622
robert caper on 'a mind of one's own' (ijpa, 78: 265-278)		1998	9651765
antifungal activity of plant extracts against dermatophytes.	the aqueous extracts (15 micrograms ml-1 medium) of 22 plants used in folkloric medicine in palestine were investigated for their antifungal activity and minimum inhibitory concentrations (mics) against nine isolates of microsporum canis, trichophyton mentagrophytes and trichophyton violaceum. the extract of the different plant species reduced colony growth of the three dermatophytes by 36 to 100% compared with the control treatment. antimycotic activity of the extract against the three dermatop ...	1999	10680445
lectins and toxins in the plant diet of phlebotomus papatasi (diptera: psychodidae) can kill leishmania major promastigotes in the sandfly and in culture.	leishmania major promastigotes are agglutinated and die in their vector, phlebotomus papatasi, after the sandflies feed on some plants that are found in their natural habitat. in in-vitro assays, extracts of ricinus communis (euphorbiaceae), capparis spinosa (capparaceae), prosopis farcta (mimosaceae) and tamarix nilotica (tamaricaceae) agglutinated and killed the parasites. this activity could be inhibited by specific carbohydrates, indicating that it was the result of various lectins in the ex ...	1999	10656036
antihepatotoxic activity of p-methoxy benzoic acid from capparis spinosa.	p-methoxy benzoic acid isolated from the methanolic soluble fraction of the aqueous extract of capparis spinosa l. (capparidaceae) was found to possess significant antihepatotoxic activity against carbontetrachloride and paracetamol induced hepatotoxicity in vivo and thioacetamide and galactosamine induced hepatotoxicity in isolated rat hepatocytes, using in vitro technique. the compound was characterized through physicochemical and spectral studies. isolation, identification and antihepatotoxic ...	1999	10433476
photosynthesis modulates the plant feeding of phlebotomus papatasi (diptera: psychodidae).	phlebotomus papatasi (scopoli), the vector of leishmania major (yakimoff & schokhor), feeds on plants in desert habitats in the jordan valley. at the end of the dry summer, the life span of sand flies is short and the amount of sugars in their guts is small. in this season the plants are under the stress of heat and dehydration. this stress arrests the photosynthesis and decreases the amounts of the main end products, sucrose and starch. we presumed that the paucity of sugars in the sand fly pla ...	2000	15535571
quercetin triglycoside from capparis spinosa.	in addition to rutin, quercetin 3-o-glucoside and quercetin 3-o-glucoside-7-o-rhamnoside, the methanolic extract of the aerial parts of capparis spinosa yielded the new flavonoid quercetin 3-o-[6'"-alpha-l-rhamnosyl-6"-beta-d-glucosyl]-beta-d-glucoside (1).	2000	11449469
hplc-uv and hplc-positive-esi-ms analysis of the diterpenoid fraction from caper spurge (euphorbia lathyris) seed oil.	caper spurge (euphorbia lathyris l.) seed oil contains a series of diterpenoids known as euphorbia factors, or l-factors, l1-l9. they are esters of several polyols (lathyrol, epoxylathyrol, hydroxylathyrol and ingenol) and account for about 3-5% of the oil. the percentage of ingenol-based l-factors is very low, less than 5% of the diterpenoid fraction, but some of them (factors l5 and l6) are responsible for the irritant and co-carcinogenic activities of the oil. this paper reports an hplc-uv an ...	2001	11705332
phlebotomus papatasi and leishmania major parasites express alpha-amylase and alpha-glucosidase.	alpha-amylase and alpha-glucosidase activities were found in homogenates of young, unfed male and female phlebotomus papatasi and in gut and salivary gland preparations. a significant increase in both enzyme activities in females and of alpha-amylase in males was recorded for flies that had fed overnight on a plant (capparis spinosa). after plant feeding, alpha-amylase activity was relatively lower in female salivary glands and higher in guts, while in the males the activity in the salivary glan ...	2001	11164750
in vitro antioxidant and in vivo photoprotective effects of a lyophilized extract of capparis spinosa l buds.	the aim of the present study was to evaluate the in vitro antioxidant and in vivo photoprotective activities of a lyophilized extract of capparis spinosa l. (lecs) obtained by methanolic extraction from the flowering buds of this plant. for the in vitro experiments, lecs was tested employing three different models: (a). bleaching of the stable 1,1-diphenyl-2-picrylhydrazyl radical (dpph test); (b). peroxidation, induced by the water-soluble radical initiator 2,2'-azobis(2-amidinopropane) hydroch ...	2002	12512010
glucosinolate composition of young shoots and flower buds of capers (capparis species) growing wild in turkey.	the content and glucosinolate composition of young shoots and raw flower buds of capparis spinosa var. spinosa and capparis ovata desf. var. canescens at three different sizes (x <or= 8 mm, 8 < x <or= 13 mm, and x > 13 mm) were investigated by hplc with uv detection. samples were harvested in august 2001 in turkey. twelve different glucosinolates were identified in the young shoots and buds of both species. total content of glucosinolates ranged from 6.55 micromol/g (large buds of c. spinosa) to ...	2002	12452652
evaluation of extracts and isolated fraction from capparis spinosa l. buds as an antioxidant source.	the antioxidant activity of extracts from capparis spinosa l. buds was evaluated using different in vitro tests: ascorbate/fe(2+)-mediated lipid peroxidation of microsomes from rat liver; bleaching of 1,1-diphenyl-2-picryl-hydrazyl radical; and autoxidation of fe(2+) ion in the presence of bathophenanthroline disulfonate. the methanolic extract showed strong activities in all of these in vitro tests. the amount of total phenols was determined in the methanolic extract. in addition, the level of ...	2002	11853498
screening of some indigenous qatari medicinal plants for antimicrobial activity.	aqueous, ethanol and butanol crude extracts of the aerial parts of ten plants exhibited variable degrees of antimicrobial activity against four bacterial and two fungal species. aqueous extracts had low antimicrobial activity against e.coli, p.aeruginosa, b. cerreus, s.aureus, c.albicans and a.flavus. avicennia marina (am) aqueous extract exhibited a moderate antifungal activity. ethanol and butanol crude extracts exhibited an improved antimicrobial activity. however, butanol exhibited a superio ...	2002	12458480
molecular cloning and characterization of caper, a novel coactivator of activating protein-1 and estrogen receptors.	transcriptional coactivators either bridge transcription factors and the components of the basal transcription apparatus and/or remodel the chromatin structures. we isolated a novel nuclear protein based on its interaction with the recently described general coactivator activating signal cointegrator-2 (asc-2). this protein caper (for coactivator of activating protein-1 (ap-1) and estrogen receptors (ers)) selectively bound, among the many transcription factors we tested, the ap-1 component c-ju ...	2002	11704680
(6s)-hydroxy-3-oxo-alpha-ionol glucosides from capparis spinosa fruits.	two new (6s)-hydroxy-3-oxo-alpha-ionol glucosides, together with corchoionoside c ((6s,9s)-roseoside) and a prenyl glucoside, were isolated from mature fruits of capparis spinosa. the structures were established on the basis of spectroscopic, chiroptic and chemical evidence. in addition, the 13c-resonance of c-9 was found to be of particular diagnostic value in assigning the absolute configuration at that center in ionol glycosides. the alpha-ionol derivatives are metabolites of (+)-(s)-abscisic ...	2002	11830166
a new p-glycoprotein inhibitor from the caper spurge (euphorbia lathyris).	the macrocyclic lathyrane polyester euphorbia factor l10 (1a) has been obtained from the seeds of the caper spurge (e. lathyris). the interaction of l10 (1a) and its acetyl derivative (1b) with p-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. the results established lathyrane diterpenoids as a novel chemotype for p-glycoprotein inhibitors.	2003	12542364
development and structure of drought-tolerant leaves of the mediterranean shrub capparis spinosa l.	capparis spinosa (caper), a winter-deciduous perennial shrub, is a consistent floristic element of mediterranean ecosystems, growing from may to october, i.e. entirely during the prolonged summer drought. the internal architecture of young and fully expanded leaves was studied, along with certain physiological characteristics. capparis spinosa possesses thick, amphistomatic and homobaric leaves with a multilayered mesophyll. the latter possesses an increased number of photosynthesizing cells per ...	2003	12853284
the chemical constituents of capparis spinosa of jordanian origin.	investigation of capparis spinosa of jordanian origin lead to isolation of two new compounds beta-sitosterylglucoside-6'-octadecanoate (1) and 3-methyl-2-butenyl-beta-glucoside (2). linked scan ms measurements were used to propose a mass fragmentation pattern for the alkaloid cadabicine isolated here for the second time from nature.	2003	12674136
induced changes in biochemical parameters of the molluscan tissues non-infected using two potent plants molluscicides.	effect of capparis spinosa (c. spinosa) and acacia arabica (a. arabica) dry powder as plant molluscicide on some glycolytic and gluconeogenic enzymes on snail tissues, was investigated. lactate debydrogenase (ldh), pyruvate kinase (pk), hexokinase (hk), phosphofructokinase (pfk), glucose phosphate isomerase (gpi) as important glycolytic enzymes, were markedly manipulated by both plants when measured one day and one week post-treatment. on the other hand glucose-6-phosphatase (g-6pase), fructose ...	2004	15287176
influence of capparis spinosa and acacia arabica on certain biochemical haemolymph parameters of biomphalaria alexandrina.	the work investigated the molluscicidal potency of dried capparis spinosa and acacia arabica leaves on selected biochemical parameters of bionimphalaria alexandrina, in order to render them, physiologically, unsuitable for s. mansoni infection or at least disturb the life-cycle of the parasite within its respective snail host. the effect of the two plants on lactate dehydrogenase (ldh), 5'-nucleotidase, acid phosphatase (ap), aspartate and alanine aminotransferases (ast & alt), alkaline phosphat ...	2004	15287187
herbs as a food source in turkey.	medical benefits of herbs have been known for centuries. many examples contain powerful active components that, if used correctly, can help in healing the living organism. these herbs can also be provided in the form of capsules and powders, as dietary supplements, and thus differ from conventional foods or food ingredients. the traditional turkish kitchen is rich of various herbs which have been employed as ingredients since ancient times. the present paper provides a brief overview of some imp ...	2004	15373716
caraway and caper: potential anti-hyperglycaemic plants in diabetic rats.	the hypoglycaemic effect of aqueous extracts of carum carvi (cc) and capparis spinosa l. (cs) fruit were investigated in normal and streptozotocin (stz) diabetic rats. after a single dose or 14 daily doses, oral administration of the aqueous cc and cs extracts (20 mg/kg) produced a significant decrease on blood glucose levels in stz diabetic rats (p < 0.001); the blood glucose levels were nearly normalised 2 weeks after daily repeated oral administration of both aqueous cc and cs extracts (20 mg ...	2004	15261975
the great copyright caper of 1986.		2004	3639002
fungal endophytes from the three-leaved caper, crataeva magna (lour.) dc. (capparidaceae).	fungal endophytes were isolated from crataeva magna, a medicinal plant growing along the streams and rivers, constituting riparian vegetation in karnataka, southern india. fresh bark and twig pieces were used for the isolation using standard methods. ninety-six endophytic fungal isolates were isolated from 800 bark and twig segments. mitosporic fungi represented as a major group (85%) followed by zygomycetes (10%) and ascomycetes (5%). bark samples contained more endophytes than twig samples. ve ...	2005	15770450
the influence of growth regulators on shoot proliferation and rooting of in vitro propagated caper.	the objectives of this study were to examine the effect of tdz and bap on shoot proliferation and to develop a satisfactory rooting procedure for in vitro propagation of caper (capparis spinosa l). tdz was found to be more effective than bap in shoot production. the highest shoot number per explant (45.7) was achieved on the media that contained 4.54 microm tdz in the absence of iaa. tdz at 4.54 microm alone or in combination with 0.57 microm iaa did not inhibit shoot elongation, although they p ...	2005	16334286
microbiological study of lactic acid fermentation of caper berries by molecular and culture-dependent methods.	fermentation of capers (the fruits of capparis sp.) was studied by molecular and culture-independent methods. a lactic acid fermentation occurred following immersion of caper berries in water, resulting in fast acidification and development of the organoleptic properties typical of this fermented food. a collection of 133 isolates obtained at different times of fermentation was reduced to 75 after randomly amplified polymorphic dna (rapd)-pcr analysis. isolates were identified by pcr or 16s rrna ...	2005	16332762
resistance to antimicrobial agents in lactobacilli isolated from caper fermentations.	a collection of lactobacilli comprising species of lactobacillus plantarum (43 isolates), lactobacillus brevis (9 isolates) and lactobacillus fermentum (6 isolates) obtained from spontaneous fermentations of capers (the fruits of capparis spinosa) were investigated for resistance to antimicrobial agents. all isolates were resistant to vancomycin and teicoplanin (mic > 16 microg/ml). resistance to ciprofloxacin (mic > 2 microg/ml) was detected in all isolates of l. brevis and l. fermentum as well ...	2005	16284934
glucosinolates and fatty acid, sterol, and tocopherol composition of seed oils from capparis spinosa var. spinosa and capparis ovata desf. var. canescens (coss.) heywood.	seed oils of 11 samples of capparis ovata and capparis spinosa from different locations in turkey were characterized with regard to the composition of fatty acids, tocopherols, and sterols as well as the content of glucosinolates. the oil content of the seeds ranged from 27.3 to 37.6 g/100 g (c. spinosa) and from 14.6 to 38.0 g/100 g (c. ovata). the dominating fatty acid of both species was linoleic acid, which accounted for 26.9-55.3% in c. ovata seed oils and for 24.6-50.5% in c. spinosa seed ...	2005	16131121
protective effect of capparis spinosa on chondrocytes.	the aim of the present study was to evaluate the in vitro chondroprotective effects of the lyophilised methanolic extract from flowering buds of capparis spinosa l (lecs). this plant, common to the mediterranean basin, has been used by the traditional medicine for its diuretic and antihypertensive effects and also in certain pathological conditions related to uncontrolled lipid peroxidation. the extract contains many constituents, in particular some flavonoids (kaempferol and quercetin derivativ ...	2005	15946691
hypolipidemic activity of aqueous extract of capparis spinosa l. in normal and diabetic rats.	the purpose of this study was to examine the effect of single and repeated oral administrations of the aqueous extract of capparis spinosa l. (cs) at a dose of 20mg/kg on lipid metabolism in normal and streptozotocin-induced diabetic rats. in normal rats, the aqueous extract of cs induced a significant decrease on plasma triglycerides concentrations 1 week (p<0.05) and 2 weeks (p<0.01) after once daily repeated oral administration. a significant decrease of plasma cholesterol levels was also obs ...	2005	15814271
antiallergic and antihistaminic effect of two extracts of capparis spinosa l. flowering buds.	the antiallergic properties of two lyophilized extracts obtained from capparis spinosa l. flowering buds (capers) by methanol extraction, carried out at room temperature (cap-c) or with heating at 60 degrees c (cap-h), were investigated. the protective effects of cap-h and cap-c, orally administered (14.28 mg[sol ]kg), were evaluated against oleaceae antigen challenge-induced and histamine-induced bronchospasm in anaesthetized guinea-pigs. furthermore, the histamine skin prick test was performed ...	2005	15799005
mineral composition of different parts of capparis ovata desf. var. canescens (coss.) heywood growing wild in turkey.	major and minor mineral contents of young shoots, flower buds, caperberries (fruit), and seeds of capparis ovata desf. var. canescens (coss.) heywood, used as a pickling product in turkey, were determined by inductively coupled plasma atomic emission spectrometry. twenty-one minerals were assayed in samples. all materials contained high amounts of ca, k, mg, na, p, pb, and zn. the highest levels of ca (598.34-16,947.1 ppm), k (3,093.1-28,163.9 ppm), na (57.9-444.3 ppm), p (1,690.5-4,153.9 ppm), ...	2005	16176156
the efficacy of liv-52 on liver cirrhotic patients: a randomized, double-blind, placebo-controlled first approach.	cirrhosis is the irreversible sequel of various disorders that damage liver cells permanently over time. presently, the use of herbal medicines for prevention and control of chronic liver diseases is in the focus of attention for both the physicians and the patients; the reasons for such shift toward the use of herbals include the expensive cost of conventional drugs, adverse drug reactions, and their inefficacy. in the present study, the efficacy of herbal medicine liv-52 (consisting of mandur ...	2005	16194047
steroid hormone receptor coactivation and alternative rna splicing by u2af65-related proteins caperalpha and caperbeta.	increasing evidence indicates that transcription and pre-mrna processing are functionally coupled to modulate gene expression. here, we report that two members of the u2af65 family of proteins, hcc1.3, which we call caperalpha, and a related protein, caperbeta, regulate both steroid hormone receptor-mediated transcription and alternative splicing. the caper proteins coactivate the progesterone receptor in luciferase transcription reporter assays and alter alternative splicing of a calcitonin/cal ...	2005	15694343
effects of cold stratification on germination rate and percentage of caper (capparis ovata desf.) seeds.	caper is an important plant because of its high adaptability to marginal agriculture fields that are not suitable for agricultural crops. different parts of caper such as roots, fruits, flowers and buds can be used to increase the inhabitant's income. the goal of this research is to determine germination rate and percentage of caper according to different duration of cold stratification (10, 20, 30, 40, 50 and 60 days) treatments. cold stratification procedures under greenhouse condition were ap ...	2006	17405328
plants used for the treatment of diabetes in israel.	in an extensive ethnobotanical survey (130 informants) of the medicinal plants of israel, 16 species were found to be used for hypoglycaemic treatments. the list includes achillea fragrantissima (forssk.) sch.-bip, ammi visnaga (l.) lam, atriplex halimus l., capparis spinosa l., ceratonia siliqua l., cleome droserifolia (forssk.) del., eryngium creticum lam., inula viscosa (l.) ait., matricaria aurea (loefl.) sch.-bip, origanum syriaca l., paronychia argentea lam, prosopis farcta (banks et sol.) ...	2006	3613607
a scoring system for the follow up study of nuclear receptor coactivator complexes.	we have systematically isolated a variety of coactivator complexes from hela s3 cells using proteomic approaches. in the present report, we have evaluated twelve coactivator complexes involved in nuclear receptor-dependent gene transcription that have been purified by using an immunoprecipitation method. the twelve purified coactivator complexes are src-1, src-2, src-3, cbp, p300, caper, e6-ap, asc-1, corest, crsp3, crsp2, and cdk7 containing complexes. we have identified 153 protein components ...	2006	16862220
plasmid profile patterns and properties of pediococci isolated from caper fermentations.	a collection comprising 14 isolates of pediococcus pentosaceus and one pediococcus acidilactici from the fermentation of caper fruits was studied. all isolates showed very similar fermentation profiles and produced a limited number of exoenzymes. all isolates carried large plasmids of diverse sizes between 20 and 55 kb, while some also contained smaller plasmids between 10 and 16 kb. cluster analysis of plasmid profiles revealed four main groups with various degrees of similarities. all amino ac ...	2006	16715824
characterization of lactobacilli isolated from caper berry fermentations.	to determine the metabolic and functional properties of lactobacilli isolated from caper fermentation.	2007	17241365
signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, pcbp1.	transcription, splicing, and translation are potentially coordinately regulatable in a temporospatial-dependent manner, although supporting experimental evidence for this notion is scarce. yeast two-hybrid screening of a mammary gland cdna library with human p21-activated kinase 1 (pak1) as bait identified polyc-rna-binding protein 1 (pcbp1), which controls translation from mrnas containing the dice (differentiation control element). mitogenic stimulation of human cells phosphorylated pcbp1 on t ...	2007	17389360
the discovery of capparis spinosa l. (capparidaceae) in the yanghai tombs (2800 years b.p.), nw china, and its medicinal implications.	seed clumps of capparis spinosa l. together with shoots, leaves and fruits of cannabis sativa l. were unearthed in the yanghai tombs, turpan district in xinjiang, china. this is the first time that plant remains of capparis spinosa have been discovered in china and the eastern part of central asia. based on the joint occurrence of capparis spinosa and cannabis sativa, and the pharmacological value of the seeds of capparis spinosa, it is deduced that caper was utilized for medicinal purposes.	2007	17693045
bioactive components of caper (capparis spinosa l.) from sicily and antioxidant effects in a red meat simulated gastric digestion.	an increasing body of evidence on the association between adherence to the mediterranean diet and healthy status is being accumulated. floral buds of capparis spinosa l. are commonly used in the mediterranean cuisine as flavoring for meat and other foods. the present study evaluated bioactive components and antioxidant activity of sicilian capers stabilized in salt. whereas alpha-tocopherol was absent, low levels of gamma-tocopherol and vitamin c were measured. with reference to one serving size ...	2007	17887802
[advances on investigation of chemical constituents, pharmacological activities and clinical applications of capparis spinosa].	in this paper, the chemical constituents, pharmacological activities and clinical applications of capparis spinosa had been reviewed. the constituents of c. spinosa include the saccharides and glycosides, flavonoids, alkaloids, terpenoids and volatile oils, fatty acids and steroides and so on. c. spinosa had many extensive pharmacological effects such as anti-inflammatory, odynolysis, antifungus, hepatoprotective effect, hypoglycemic activity, antioxidation, anti-hyperlipemia, anticoagulated blo ...	2008	19149246
rutin from different parts of capparis spinosa growing wild in khuzestan/iran.	a qualitative and quantitative analysis of rutin from leaves, fruits and flowers of capparis spinosa growing wild in khuzestan was achieved. after soxhelet extraction of fats in diethyl ether, rutin was extracted by maceration using 50% etoh. the ethanol extracts of these parts were separated by preparative tlc on silica gel precoated plate with a mixture of butanol: acetic acid (4:1, by volume) as the developing solvent. the spots were visualized under ultraviolet light (254 nm). rutin was qual ...	2008	18819575
antiviral and immunomodulatory effect of a lyophilized extract of capparis spinosa l. buds.	herpes simplex virus type 1 (hsv-1) and herpes simplex virus type 2 (hsv-2) are common human pathogens that in particular cases can also cause severe problems especially in immunodeficient patients. the present paper reports the antiviral and immunomodulatory properties of a methanolic extract of c. spinosa buds (cap), rich in flavonoids, including several quercetin and kaempferol glycosides. in particular we have investigated whether the in vitro exposure of human peripheral blood mononuclear c ...	2008	18058988
[effect of capparis spinosa on fibroblast proliferation and type i collagen production in progressive systemic sclerosis].	to investigate the effects of ethanolic extract from capparis spinosa (ecs) on the fibroblast proliferation and type i collagen production in normal and progressive systemic sclerosis (pss).	2008	18536384
investigation on the mineral contents of capers (capparis spp.) seed oils growing wild in turkey.	minor and major mineral contents of seed oils of capparis ovata desf. var. canescens (coss.) heywood and capparis spinosa var. spinosa used as pickling products in turkey were determined by inductively coupled plasma atomic emission spectrometry. the seed oils contained al, p, na, mg, fe, and ca, in addition to fatty acids. the highest mineral concentrations measured were 14.91-118.81 mg/kg al, 1,489.34-11,523.74 mg/kg p, 505.78-4,489.51 mg/kg na, 102.15-1,655.33 mg/kg mg, 78.83-298.14 mg/kg fe, ...	2008	18800913
effects of a new nutraceutical ingredient on allergen-induced sulphidoleukotrienes production and cd63 expression in allergic subjects.	allergic diseases represent conditions affecting millions of individuals across the world. the objective of this study was to investigate the potential anti-allergic effects of a new nutraceutical ingredient, pantescal (bionap, italy), contained in different food supplements. pantescal is a mixture of plant extracts, such as capparis spinosa, olea europaea, panax ginseng and ribes nigrum. the study was a randomized, double-blind, placebo controlled design. 60 patients allergic to common aeroalle ...	2008	18817894
a protein with antiproliferative, antifungal and hiv-1 reverse transcriptase inhibitory activities from caper (capparis spinosa) seeds.	a protein exhibiting an n-terminal amino acid sequence with some similarity to imidazoleglycerol phosphate synthase was purified from fresh capparis spinosa melon seeds. the purification protocol entailed anion exchange chromatography on deae-cellulose, cation exchange chromatography on sp-sepharose, and finally gel filtration by fast protein liquid chromatography on superdex 75. the protein was adsorbed using 20 mm tris-hcl buffer (ph 7.4) and desorbed using 1 m nacl in the starting buffer from ...	2009	19019643
genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of dcis-like mammary lesions.	caveolin-1 (cav-1) loss-of-function mutations are exclusively associated with estrogen receptor-positive (er(+)) human breast cancers. to dissect the role of cav-1 loss-of-function in the pathogenesis of human breast cancers, we used cav-1(-/-) null mice as a model system. first, we demonstrated that cav-1(-/-) mammary epithelia overexpress two well-established er co-activator genes, caper and foxa1, in addition to er-alpha. thus, the functional loss of cav-1 may be sufficient to confer estrogen ...	2009	19342371
carotenoid and tocopherol composition of leaves, buds, and flowers of capparis spinosa grown wild in tunisia.	high-performance liquid chromatography was used to determine carotenoids (beta-carotene, lutein, neoxanthin, and violaxanthin) and tocopherols of leaves, buds, and flowers of tunisian capparis spinosa. this plant shows strong resistance to hard environmental conditions, and it is one of the most commonly found aromatics in the mediterranean kitchen. in this study, the means of the total carotenoids were 3452.5 +/- 1639.4, 1002 +/- 518.5, and 342.7 +/- 187.9 microg/g fresh weight (fw) in leaves, ...	2009	19473002
exposure to euphorbia lathyris latex resulting in alkaline chemical injury: a case report.	we report the case of a patient with extreme pain following accidental exposure to the latex of euphorbia lathyris.	2009	19946593
isolation and characterization of a lectin with potentially exploitable activities from caper (capparis spinosa) seeds.	a dimeric 62-kda lectin exhibiting a novel n-terminal amino acid sequence was purified from caper (capparis spinosa) seeds. the purification protocol involved anion-exchange chromatography, cation-exchange chromatography and, finally, gel filtration by fplc on superdex 75. approx. 100-fold purification was achieved. the haemagglutinating activity of the lectin, which was stable in the ph range 1-12 and up to 40 degrees c, could be inhibited by d(+) galactose, alpha-lactose, raffinose and rhamnos ...	2009	18847434
an examination of the function of male flowers in an andromonoecious shrub capparis spinosa.	the pollen donor and pollinator attractor hypotheses are explanations for the functions of the male flowers of andromonoecious plants. we tested these two hypotheses in the andromonoecious shrub capparis spinosa l. (capparaceae) and confirmed that pollen production and cumulative volume and sugar concentration of nectar do not differ between male and perfect flowers. however, male flowers produced larger anthers, larger pollen grains and smaller ovaries than perfect flowers. observations on poll ...	2009	19261075
effect of tunisian capparis spinosa l. extract on melanogenesis in b16 murine melanoma cells.	the effect of tunisian capparis spinosa l. aromatic plant extract on melanogenesis regulation in b16 murine melanoma cells was investigated. b16 cells were treated with 0.0005, 0.005, and 0.05% (w/v) c. spinosa extract after which the melanin content and cell viability were measured. to clarify the mechanism behind melanogenesis regulation, the expression of tyrosinase was determined. results showed that the extract had a significant stimulative effect on melanogenesis in b16 cells in a dose-dep ...	2009	19685105
the caper studies: five case-control studies aimed at identifying and quantifying the risk of cancer in symptomatic primary care patients.	this paper reviews the background to five primary care case-control studies, collectively known as the caper studies (cancer prediction in exeter). these studies, on colorectal, lung, prostate and brain tumours, sought to identify the particular features of cancer as reported to primary care. they also sought to quantify the risk of cancer for symptoms and primary care investigations, both individually and paired together.	2009	19956169
aspects of vitamin a.	musgrave park hospital in 1942 was the site of an anglo-american vitamin a caper. a threatened court-martial was pre-empted. subsequently the queen's lecturer in anatomy, jw millen, who was the other lecturer to the first editor of this journal, rh hunter, did much distinguished work. the neurological effects of vitamin a were elucidated. further work on cerebrospinal fluid (csf), placenta, thalidomide and poliomyelitis led to the pre-eminence in applied anatomy and teratology of now reader jame ...	2009	19907684
effects of different temperatures and duration on germination of caper (capparis ovata) seeds.	caperseed has poor germination because of the seed coat dormancy germination of caperseeds are complex traits affected by a wide range of intemal and environmental influences. the effects of temperature preconditioning and period on germination of capparis ovata were examined. experiments were conducted in order to investigate germination behaviour of caperseeds subjected to different temperature and duration. the experiment revealed that the different temperature treatments were effective on me ...	2009	20120507
[tissue culture and rapid propogation of seeds of uyghur traditional herbal capparis spinosa].	to optimize the tissue culture and rapid proliferation techniques of seeds of capparis spinosa for producing large scale seedlings.	2010	21548355
a new antioxidant compound from capparis spinosa.	an activity-directed fractionation and purification process was used to isolate 1,1-diphenyl-2-picrylhydrazyl radical (dpph) scavenging components from fruits of capparis spinosa l. (capparaeae). ethyl acetate and aqueous fractions showed greater dpph scavenging activities compared to the petroleum ether fractions. the ethyl acetate fraction was subjected to purification using column chromatography. a new antioxidant cappariside (4-hydroxy-5-methylfuran-3-carboxylic acid, 1), together with sev ...	2010	20645804
capparis spinosa protects against oxidative stress in systemic sclerosis dermal fibroblasts.	high reactive oxygen species (ros), ha-ras, and active erk1/2 in fibroblasts play an essential role in the pathogenesis of systemic sclerosis (ssc). the present study was carried out to evaluate the effects of the ethanol extract from fruits of capparis spinosa l. (ecs) on oxidative stress and ros-erk1/2-ha-ras signal loop in ssc dermal fibroblasts in vitro. cultured dermal fibroblasts from three ssc patients and three normal controls were treated with ecs by different concentration (10, 50, 100 ...	2010	19851777
phenolic compounds and vitamin antioxidants of caper (capparis spinosa).	capparis spinosa shows strong resistance to the adverse mediterranean conditions and it has nutritional and medicinal value. the aim of this study was to evaluate the contents of total phenolic compounds, rutin, tocopherols, carotenoids and vitamin c in leaves and flower buds of c. spinosa from different locations in tunisia. results showed the richness of caper with these compounds, especially phenolic compounds. interestingly, it was also found the presence of both α- and γ-tocopherol in buds. ...	2010	20668946
anti-inflammatory effects of caper (capparis spinosa l.) fruit aqueous extract and the isolation of main phytochemicals.	caper (capparis spinosa l.) fruits have been used as food as well as folk medicine in the treatment of inflammatory disorders, such as rheumatism. the present study was carried out to study the anti-inflammatory activities of c. spinosa l. fruit (csf) aqueous extract and to isolate main phytochemicals from its bioactive fractions. the csf aqueous extract were separated into three fractions (csf1-csf3) by macroporous adsorption resins. the fractions csf2 and csf3 effectively inhibited the carrage ...	2010	21105652
effect of ethnomedicinal plants used in folklore medicine in jordan as antibiotic resistant inhibitors on escherichia coli.	escherichia coli occurs naturally in the human gut; however, certain strains that can cause infections, are becoming resistant to antibiotics. multidrug-resistant e. coli that produce extended-spectrum beta lactamases (esbls), such as the ctx-m enzymes, have emerged within the community setting as an important cause of urinary tract infections (utis) and bloodstream infections may be associated with these community-onsets. this is the first report testing the antibiotic resistance-modifying acti ...	2010	20187978
in vitro activities of plant extracts from saudi arabia against malaria, leishmaniasis, sleeping sickness and chagas disease.	the in vitro activity of the methanol extracts of 51 plants randomly collected from the kingdom of saudi arabia and some of their fractions (petroleum ether, chloroform, ethyl acetate and aqueous) were evaluated against plasmodium falciparum, trypanosoma brucei brucei, t. cruzi and leishmania infantum, as well as toxicity against mrc-5 fibroblast cells. ten crude methanolic extracts that demonstrated potent and adequately selective antiprotozoal activity were subjected to solvent fractionation u ...	2010	20127723
antinociceptive activity of methanol extract of fruits of capparis ovata in mice.	capparis ovata desf. and capparis spinosa l. have wide natural distribution in turkey and they are consumed in pickled form. flower buds, root bark, and fruits of the plant are used in folk medicine due to their analgesic, wound healing, cell regeneration, tonic, and diuretic effects.	2010	20595018
on the antibacterial activity of roots of capparis spinosa l.	a decoction of capparis spinosa l. roots, widely used in the traditional folk medicine of southern italy, was prepared and submitted to antibacterial activity tests, which showed an interesting bacteriostatic activity on the growth of deinococcus radiophilus. heterocyclic compounds were also recovered from the chloroformic extract of the roots.	2011	21328135
phenolic composition and antioxidant activity of aqueous infusions from capparis spinosa l. and crithmum maritimum l. before and after submission to a two-step in vitro digestion model.	this study investigated the phenolic composition and antioxidant activities of aqueous infusions from wild-grown caper (capparis spinosa l.) and sea fennel (crithmum maritimum l.) from the dalmatia region (croatia) before and after their submission to an in vitro digestion process. hplc/uv-vis-dad/esi-ms analysis of the caper infusion identified rutin, kaempferol 3-o-rutinoside, and isorhamnetin 3-o-rutinoside as dominant flavonoids in the matrix together with a series of cinnamoylquinic acid de ...	2011	22017607
antiquorum sensing and antibiofilm potential of capparis spinosa.	emergence of antibiotic resistance among bacterial pathogens often leads to the failure of existing antibiotics to treat bacterial infections; thus, there is a need to seek alternative treatment measures. the aim of this study was to evaluate the anti-quorum sensing (anti-qs) and antibiofilm potential of capparis spinosa to prevent the onset of bacterial infections as an alternate to antibiotics.	2011	22222491
structure identification of euphorbia factor l3 and its induction of apoptosis through the mitochondrial pathway.	in this article, we have focused on the structure identification of euphorbia factor l3 belonging to the lathyrane diterpenoids isolated from caper euphorbia seed. its anticancer activity in vitro against lung cancer a549 cells was also investigated and the ic(50) values were 34.04 ± 3.99 μm. furthermore, euphorbia factor l3 could induce apoptosis in a549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.	2011	21499222
biflavonoids from caper (capparis spinosa l.) fruits and their effects in inhibiting nf-kappa b activation.	caper (capparis spinosa l.) fruits have been widely used as food and folk medicine in the mediterranean basin and in central and west asia. in this study, two biflavonoids, isoginkgetin, and ginkgetin, together with three other flavonoids, were isolated from caper fruits. their chemical structures were elucidated by spectroscopic analyses and comparison with literature. to our knowledge, isoginkgetin, ginkgetin and sakuranetin were identified in caper for the first time. notably, it is also the ...	2011	21381749
the diagnostic performance of scoring systems to identify symptomatic colorectal cancer compared to current referral guidance.	to determine the discrimination characteristics of a new algorithm and two existing symptom scoring systems for identification of patients with suspected colorectal cancer.	2011	21357592
the caper (capparis l.): ethnopharmacology, phytochemical and pharmacological properties.	caper (capparis l.), a shrub plant with a large natural distribution, is used in traditional medicines to cure various illnesses. phytochemicals studies have shown the presence of many beneficial compounds such as spermidine, rutin, quercetin, kaempferol, stigmasterol, campesterol, tocopherols, and carotenoids. biological studies reveal important antimicrobial, anti-oxidative, anti-inflammatory, immunomodulatory and antiviral properties. the presented review summarizes information concerning the ...	2011	20851750
the use of erlotinib in daily practice: a study on adherence and patients' experiences.	adherence to pharmacological therapy is a complex and multi-factorial issue that can substantially alter the outcome of treatment. it has been shown that cancer patients, especially when using long-term medication, have similar adherence rates to those of patients with other diseases. the consequences of poor adherence are poor health outcomes and increased health care costs. only few studies have focused on the use of oral anticancer agents in daily practice. information about the reasons for n ...	2011	21722354
anti-arthritic active fraction of capparis spinosa l. fruits and its chemical constituents.	the aim of this study was to ascertain the anti-arthritic active fraction of capparis spinosa l. (capparidaceae) fruits and its chemical constituents. the adjuvant arthritic rat model was developed to evaluate the anti-arthritic effects of different fractions of ethanol extraction from c. spinosa l. the fraction eluted by ethanol-water (50:50, v/v) had the most significant anti-arthritic activity. the chemical constituents of this fraction were therefore studied; seven known compounds were isola ...	2011	21372539
florida's tin can caper.		2011	5040555