Publications

[anti-inflammatory activity of holly extracts (ruscus aculeatus l.)].		1965	14279883
[the anti-edematous effect of an association of proteolytic enzymes, flavonoids, sterolic heteroside of ruscus aculeatus and ascorbic acid (author's transl)].		1979	396842
effect of ruscus aculeatus on isolated canine cutaneous veins.		1983	6298054
effect of temperature on the responsiveness of cutaneous veins to the extract of ruscus aculeatus.	in canine cutaneous veins cooling augments and warming depresses the responses to sympathetic nerve stimulation. in these veins the extract of ruscus aculeatus (ruscus) causes contractions due to alpha-adrenergic activation. to determine the effects of temperature on the response to ruscus, rings of canine saphenous veins were studied at 24 degrees, 37 degrees and 41 degrees c. at 37 degrees c, ruscus caused an increase in isometric tension which was depressed by prazosin and rauwolscine. coolin ...	1984	6150876
anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from hedera helix, aesculus hippocastanum, and ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency.	triterpene and steroid saponins and sapogenins of medicinal plants (aesculus hippocastanum l., hedera helix l., ruscus aculeatus l.) are claimed to be effective for the treatment/prevention of venous insufficiency. in this work we evaluated the inhibitory effects of these plant constituents on the activity of elastase and hyaluronidase, the enzyme systems involved in the turnover of the main components of the perivascular amorphous substance. the results evidence that for hedera helix l., the sa ...	1995	8554461
antimicrobial activity of 20 plants used in folkloric medicine in the palestinian area.	ethanolic and aqueous extracts of 20 palestinian plant species used in folk medicine were investigated for their antimicrobial activities against five bacterial species (staphylococcus aureus, escherichia coli, klebsiella pneumoniae, proteus vulgaris, pseudomonas aeruginosa) and one yeast (candida albicans). the plants showed 90% of antimicrobial activity, with significant difference in activity between the different plants. the most antimicrobially active plants were phagnalon rupestre and micr ...	1998	9613839
cyclic nucleotides and production of prostanoids in human varicose veins.	experiments were designed to determine the production of prostacyclin and thromboxane and the activation of cyclic nucleotides in human varicose and nonvaricose veins and to determine whether these second messenger pathways were differentially activated by the venotropic extract of ruscus aculeatus.	1999	10550185
antifungal activity of plant extracts against dermatophytes.	the aqueous extracts (15 micrograms ml-1 medium) of 22 plants used in folkloric medicine in palestine were investigated for their antifungal activity and minimum inhibitory concentrations (mics) against nine isolates of microsporum canis, trichophyton mentagrophytes and trichophyton violaceum. the extract of the different plant species reduced colony growth of the three dermatophytes by 36 to 100% compared with the control treatment. antimycotic activity of the extract against the three dermatop ...	1999	10680445
pharmacological assessment of adrenergic receptors in human varicose veins.	experiments were to characterize pharmacologically adrenergic receptors in human varicose veins to the natural transmitter norepinephrine and to an extract of ruscus.	2000	10905803
hemorrhoids and varicose veins: a review of treatment options.	hemorrhoids and varicose veins are common conditions seen by general practitioners. both conditions have several treatment modalities for the physician to choose from. varicose veins are treated with mechanical compression stockings. there are several over-the-counter topical agents available for hemorrhoids. conservative therapies for both conditions include diet, lifestyle changes, and hydrotherapy which require a high degree of patient compliance to be effective. when conservative hemorrhoid ...	2001	11302778
spatial variation in springtime food resources influences the winter body mass of roe deer fawns.	it is well established that the dynamics of mammalian populations vary in time, in relation to density and weather, and often in interaction with phenotypic differences (sex, age and social status). habitat quality has recently been identified as another significant source of individual variability in vital rates of deer, including roe deer where spatial variations in fawn body mass were found to be only about a tenth of temporal variations. the approach used was to classify the habitat into blo ...	2003	12920639
determination of anthocyanins in ruscus aculeatus l. berries.	red berries of ruscus aculeatus l., a wild shrub typical of mediterranean europe and africa, were investigated for the first time in order to determine the profile of anthocyanins. the pigments were extracted from the skins of the berries with 0.1% hcl in methanol, purified using a c-18 solid phase cartridge, and identified by means of high-performance liquid chromatography (hplc)-diode array detection-mass spectrometry analysis. information from hplc profiles, saponification, and acid hydrolysi ...	2005	15656691
traditional phytotherapy in central italy (marche, abruzzo, and latium).	in this study, the more significant results of extensive ethnopharmacobotanical research carried out by the author in the years 1977-2000 in 175 localities of three regions of central italy (marche, abruzzo, and latium) have been reported and compared. the usages of 80 species belonging to 36 families are described, of which 71 were used in human therapy and 29 in veterinary medicine. uses are suited with the number of localities in which they have been mentioned. among the wild plant mainly sti ...	2005	15664457
the effect of methyl jasmonate on triterpene and sterol metabolisms of centella asiatica, ruscus aculeatus and galphimia glauca cultured plants.	considering that exogenously applied methyl jasmonate can enhance secondary metabolite production in a variety of plant species and that 2,3-oxidosqualene is a common precursor of triterpenes and sterols in plants, we have studied centella asiatica and galphimia glauca (both synthesizing triterpenoid secondary compounds) and ruscus aculeatus (which synthesizes steroidal secondary compounds) for their growth rate and content of free sterols and respective secondary compounds, after culturing with ...	2006	16876832
chromatographic behaviour of steroidal saponins studied by high-performance liquid chromatography-mass spectrometry.	the chromatographic behaviour of steroidal saponins found in anemarrhena asphodeloides, asparagus officinalis, convallaria majalis, digitalis purpurea and ruscus aculeatus was studied by hplc-ms using a c-18 reversed-phase column and aqueous acetonitrile or aqueous methanol mobile phase gradients, with or without the addition of 1% acetic acid. the behaviour was compared to that of triterpene saponins found in aesculus hippocastanum, centella asiatica, panax notoginseng and potentilla tormentill ...	2007	17391684
possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappab.	ruscogenin (rus), first isolated from ruscus aculeatus, also a major steroidal sapogenin of traditional chinese herb radix ophiopogon japonicus, has been found to exert significant anti-inflammatory and anti-thrombotic activities. our previous studies suggested that ruscogenin remarkably inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ecv304) injured by tumor necrosis factor-alpha (tnf-alpha) in a concentration-dependent manner. yet the underlying mechanisms rem ...	2008	18946195
which plant for which skin disease? part 2: dermatophytes, chronic venous insufficiency, photoprotection, actinic keratoses, vitiligo, hair loss, cosmetic indications.	this paper continues our review of scientifically evaluated plant extracts in dermatology. after plants effective against dermatophytes, botanicals with anti-edema effects in chronic venous insufficiency are discussed. there is good evidence from randomized clinical studies that plant extracts from grape vine leaves (vitis vinifera), horse chestnut (aesculus hippocastanum), sea pine (pinus maritima) and butcher's broom (ruscus aculeatus) can reduce edema in chronic venous insufficiency. plant ex ...	2010	20707877
[multicentric study on a topical compound with lymph-draining action in the treatment of the phlebostatic ulcer of the inferior limbs].	phlebostatic sore of the lower limbs is a typical chronic venous insufficiency complication and is still a widely controversial issue in its treatment. the common therapies, in fact, are not yet standardized and they not show complete efficacy. since 2005 to 2007 a multicentric clinical trial was conducted at the plastic and reconstructive surgery of "sapienza" university of rome and at the plastic and reconstructive surgery department, university of perugia, in order to evaluate the efficacy of ...	2010	20109380
bioactive compounds, rp-hplc analysis of phenolics, and antioxidant activity of some portuguese shrub species extracts.	in the ecosystem of serra da estrela, some plant species have the potential to be used as raw material for extraction of bioactive products. the goal of this work was to determine the phenolic, flavonoid, tannin and alkaloid contents of the methanolic extracts of some shrubs (echinospartum ibericum, pterospartum tridentatum, juniperus communis, ruscus aculeatus, rubus ulmifolius, hakea sericea, cytisus multiflorus, crataegus monogyna, erica arborea and ipomoea acuminata), and then to correlate t ...	2011	22312726
fungal planet description sheets: 214-280.	novel species of microfungi described in the present study include the following from south africa: cercosporella dolichandrae from dolichandra unguiscati, seiridium podocarpi from podocarpus latifolius, pseudocercospora parapseudarthriae from pseudarthria hookeri, neodevriesia coryneliae from corynelia uberata on leaves of afrocarpus falcatus, ramichloridium eucleae from euclea undulata and stachybotrys aloeticola from aloe sp. (south africa), as novel member of the stachybotriaceae fam. nov. s ...	2014	25264390
hepatoprotective herbs, avicenna viewpoint.	liver injury or dysfunction is considered as a serious health problem. the available synthetic drugs to treat liver disorders are expensive and cause further damage. hence, hepatoprotective effects of some herbal drugs have been investigated, and one of the methods to choose herbs in order to study their biological effects is to search in ancient medical texts. avicenna who is known as the prince of physicians had collected and classified greek, persian and islamic medicine in the best possible ...	2014	24719702