Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| studies of the constituents of umbelliferae plants. 8. chromatographic studies on the constituents of cnidium officinale makino. | 1967 | 5583813 | |
| [cultivation experiments of cnidium officinale makino. i]. | 1967 | 5629721 | |
| [constituents of cnidium officinale makino. structure of senkyunolide and gas chromatography-mass spectrometory of the related phthalides (author's transl)]. | 1977 | 559071 | |
| components of cnidium officinale makino: occurrence of pregnenolone, coniferyl ferulate, and hydroxyphthalides. | 1984 | 6525664 | |
| [centrally acting muscle relaxant effect of phthalides (ligustilide, cnidilide and senkyunolide) obtained from cnidium officinale makino]. | the present study was carried out to elucidate a centrally acting muscle relaxant effect of chloroform soluble fraction and its component, namely, ligustilide, cnidilide and senkyunolide obtained from the rhizome of cnidium officinale makino. these three compounds were isolated from the chloroform soluble fraction by column chromatography on silica gel. the centrally acting muscle relaxant effect was investigated on the crossed extensor reflex in anesthetized rats and these samples were suspende ... | 1989 | 2810059 |
| an acidic polysaccharide having immunological activities from the rhizome of cnidium officinale. | an acidic polysaccharide, designated as cnidirhan ag, was isolated from the rhizomes of cnidium officinale makino. it was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 5.1 x 10(4). it showed pronounced reticuloendothelial system-potentiating activity in a carbon clearance test, and had a remarkable effect on both anti-complementary and alkaline phosphatase-inducing activities. it is composed of l-arabinose: d-galactose: d-glucuronic acid in the ... | 1992 | 1477918 |
| [studies on the medicinal plant in the "sambutsu-cho" of higo province possessed by the kumamoto clan (ii): on the medicina herbs]. | in the previous report, i studied the medicinal trees contained in the sambutsu-cho of the kumamoto clan in higo province. in this report, i studied the medicinal herbs contained in the same book. there were 439 names in the herbal part. i identified 214 species and found 129 species as the medicinal plants. the ratio of the medicinal plants was 60%. the famous medicinal plants were as follows: atractilodes japonica, platycodon grandiflorum, prunella vulgaris var. lilacina, pharbitis nil, cnidiu ... | 1993 | 11639722 |
| characterization of a novel heteroglucan from the rhizome of cnidium officinale exhibiting high reticuloendothelial system-potentiating and anti-complementary activities. | a novel beta-heteroglucan, called cnidirhan siia, was isolated from the rhizome of cnidium officinale makino. it was homogeneous on electrophoresis and gel chromatography, and its molecular mass was more than 1 x 10(7). it was composed of d-glucose, d-galactose and l-arabinose in the molar ratio of 85:5:8, in addition to small numbers of o-acetyl groups. methylation analysis and nuclear magnetic resonance studies indicated its main structural features composed of beta-1,6-linked d-glucopyranosyl ... | 1994 | 8000388 |
| characterization of a novel glucan, which exhibits reticuloendothelial system-potentiating and anti-complementary activities, from the rhizome of cnidium officinale. | a novel glucan, called cnidirhan si, was isolated from the rhizome of cnidium officinale makino. it was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 1.3 x 10(4). it is composed of d-glucose alone, in addition to small numbers of o-acetyl groups. methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated it has a high-branched glucan type structure composed of alpha-1,4-linked d-glucopyranose residues with both 3 ... | 1994 | 8004712 |
| inhibitory effects of oriental herbal medicines on il-8 induction in lipopolysaccharide-activated rat macrophages. | cytokine-induced neutrophil chemoattractant (cinc), a rat interleukin-8 (il-8), was quantitated by using a sensitive elisa. the cinc was induced up to 20 ng/ml from basal 1-2 ng/ml in lipopolysaccharide (lps)-activated peritoneal macrophages. this cinc induction was significantly inhibited by steroidal anti-inflammatory drugs including dexamethasone, but not by non-steroidal drugs including indomethacin at all. nine out of 59 herbal medicines which are frequently used in korean traditional presc ... | 1995 | 7700986 |
| clonal propagation of cnidium officinale by shoot tip culture. | multiple shoots were induced from the apical domes of shoot tips of cnidium officinale makino (apiaceae) by culturing them on murashige and skoog (ms) 1 static media solidified with 0.2% gelrite and supplemented with 6-benzylaminopurine (bap) 10 (-6)m. an average of 5.3 shoots per segment were obtained within 6 weeks and this ability did not decline even after two years of subculture. subsequent transfer of these regenerated shoots on ms media supplemented with alpha-naphthaleneacetic acid (naa) ... | 1996 | 17252447 |
| anti-angiogenic activities of cnidium officinale makino and tabanus bovinus. | this study investigated the anti-angiogenic activities of cnidium officinale makino and tabanus bovinus by using cultured glomerular capillary endothelial cells (gecs), chorioallantoic membrane (cam) and rat cornea. treatment of gecs with several concentrations (5-50 microg/ml) of c. officinale makino and t. bovinus extracts for 24 h inhibited angiotensin ii (10(-8) m)-induced increases of [3h]thymidine uptake and cell numbers in a concentration-dependent manner. the extent of inhibitory rate of ... | 2002 | 12127239 |
| acaricidal activity of butylidenephthalide identified in cnidium officinale rhizome against dermatophagoides farinae and dermatophagoides pteronyssinus (acari: pyroglyphidae). | the acaricidal activity of materials derived from the rhizome of cnidium officinale against adults of dermatophagoides farinae and dermatophagoides pteronyssinus was examined using direct contact application and fumigation methods and compared with that of benzyl benzoate and n,n-diethyl-m-toluamide (deet). the active constituent of the cnidium rhizome was identified as butylidenephthalide by spectroscopic analyses. responses varied with dose. on the basis of 24-h ld(50) values, the acaricidal a ... | 2002 | 12137464 |
| [matk and its nucleotide sequencing of crude drug chuanxiong and phylogenetic relationship between their species from china and japan]. | to provide more molecular evidences for species relationship between chuanxiong (ligusticum chuanxiong hort.) from china and japanese chuanxiong (senkyu in japanese) (cnidium officinale makino). | 2002 | 12579903 |
| ethyl acetate soluble fraction of cnidium officinale makino inhibits neuronal cell death by reduction of excessive nitric oxide production in lipopolysaccharide-treated rat hippocampal slice cultures and microglia cells. | in the present work, we found that the ethyl acetate-soluble fraction of cnidium officinale makino (coea) decreased nitric oxide (no) production in the lipopolysaccharide (lps)-stimulated bv-2 and primary microglia and suppressed expression of inducible nitric oxide synthase (inos) in bv-2 cells with the same pattern of no production. in addition, we showed that excessive no production played an important role in neuronal cell death in lps-treated rat hippocampal slice cultures. our data suggest ... | 2003 | 12832858 |
| falcarindiol inhibits nitric oxide-mediated neuronal death in lipopolysaccharide-treated organotypic hippocampal cultures. | excessive nitric oxide (no) release from activated microglia has a predominant role in neuronal death. this study investigated the effect of falcarindiol, which was isolated from cnidium officinale makino, on the no-mediated neuronal death in lipopolysaccharide (lps)-treated organotypic hippocampal cultures. falcarindiol dose-dependently reduced inducible no synthase (inos)-mediated no production without cytotoxic effects on lps-activated bv-2 and microglia. predictably, falcarindiol inhibited n ... | 2003 | 14561925 |
| acaricidal activity of cnidium officinale rhizome-derived butylidenephthalide against tyrophagus putrescentiae (acari: acaridae). | the acaricidal activity of materials derived from the rhizome of cnidium officinale makino against tyrophagus putrescentiae schrank adults was examined using direct contact application and fumigation methods, and compared with that of benzyl benzoate and n,n-diethyl-m-toluamide (deet). the biologically active constituent of the cnidium rhizome was identified as butylidenephthalide by spectroscopic analyses. on the basis of 24-h ld50 values, acaricidal activity was more pronounced with butylidene ... | 2003 | 12558107 |
| determination of the effectiveness of components of the herbal medicine toki-shakuyaku-san and fractions of angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test. | the improving effects of various components of toki-shakuyaku-san (tss) and fractions isolated from angelica acutiloba radix (toki) on scopolamine-induced spatial memory impairment were investigated in eight-armed radial maze. the scopolamine-induced memory impairment was characterized by prominent increase of error choices in addition to decreased correct choices. toki, cnidium officinale rhizoma (senkyu), poria cocos hoelen (bukuryo), alisma orientale rhizoma (takusha), and atractylodes lancea ... | 2004 | 15351791 |
| development of high-performance liquid chromatographic fingerprints for distinguishing chinese angelica from related umbelliferae herbs. | a high-performance liquid chromatographic (hplc) fingerprint of chinese angelica (ca) was developed basing on the consistent chromatograms of 40 ca samples (angelica sinensis (oliv.) diels). the unique properties of this hplc fingerprints were validated by analyzing 13 related herbs including 4 japanese angelicae root samples (ja, a. acutiloba kitagawa and a. acutiloba kitagawa var. sugiyame hikino), 6 szechwan lovage rhizome samples (sl, ligusticum chuanxiong hort.) and 3 cnidium rhizome sample ... | 2005 | 15909545 |
| larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of cnidium officinale against drosophila melanogaster. | the insecticidal activity of the chloroform extract of cnidium officinale rhizomes and its constituents was investigated against larvae and adults of drosophila melanogaster and compared with that of rotenone. bioassay-guided isolation of the chloroform extract of c. officinale resulted in the isolation and characterization of four alkylphthalides, cnidilide (1), (z)-ligustilide (2), (3s)-butylphthalide (3), and neocnidilide (4). the structures of these compounds were established by spectroscopi ... | 2005 | 15998112 |
| inhibitory effects of cnidium officinale makino and tabanus fulvus meigan on the high glucose-induced proliferation of glomerular mesangial cells. | this study describes a potent activity of cnidium officinale makino (cnidii rhizoma) and tabanus fulvus meigan (tabanus) as an inhibitor of high glucose-induced proliferation of glomerular mesangial cells (gmcs). raising the ambient glucose concentration from 5.6 to 25 mm for 24 h caused a dramatic increase in [3h]thymidine incorporation, and these increases were attenuated by treatment of gmcs with the extracts of cnidii rhizoma and tabanus (2.5-20 microg/ml) in a dose-dependent manner. in cont ... | 2005 | 16194052 |
| molecular identification of "chuanxiong" by nucleotide sequence and multiplex single base extension analysis on chloroplast trnk gene. | chloroplast trnk gene sequences of cnidium officinale and ligusticum chuanxiong were determined to establish an effective method for identifying japanese senkyu and chinese chuanxiong, the two which have the same drug name in chinese characters, similar external feature, but different botanical origins. three sites of nucleotide differences were found between these 2 species at positions 767,924 and 964 from upstream in trnk gene sequence, allowing molecular identification of the two plants and ... | 2007 | 17329850 |
| comparative analysis of ligusticum chuanxiong and related umbelliferous medicinal plants by high performance liquid chromatography-electrospray ionization mass spectrometry. | a highly precise and accurate method, based on high performance liquid chromatography-electrospray ionization mass spectrometry (hplc-esi-ms), was developed for the qualitative and quantitative comparison of the main constituents in the rhizome of ligusticum chuanxiong (lc) and three related umbelliferous medicinal plants. a comprehensive validation of the developed method was conducted, and the method was highly sensitive, reproducible and accurate. the unique properties of the present method w ... | 2007 | 17372865 |
| protective effect of the extracts from cnidium officinale against oxidative damage induced by hydrogen peroxide via antioxidant effect. | the dried rhizomes of cnidium officinale are used as herbal drugs in the treatment of pain, inflammation, menstrual disturbance and antivitamin deficiency disease, and also act as a blood pressure depressant. in addition, there are several reports suggesting that they have pharmacological properties to tumor metastasis and angiogenesis, and that they act as an inhibitor of high glucose-induced proliferation of glomerular mesangial cells. however, little has been known about the functional role o ... | 2009 | 19101603 |
| antioxidant activity in essential oils of cnidium officinale makino and ligusticum chuanxiong hort and their inhibitory effects on dna damage and apoptosis induced by ultraviolet b in mammalian cell. | owing to their high volatile aroma, the dried rhizomes of cnidium officinale (c. officinale) and ligusticum chuanxiong (l. chuanxiong) are used as herbal drugs to treat blood pressure depressant, a deficiency disease of antivitamin, inhibition of small intestine sympathetic nerve and as cosmetics for skin care. however, little has been known about the protective effect of their essential oils against ultraviolet b (uvb)-induced dna damage. | 2009 | 19679046 |
| evaluation of the phototoxic potential of plants used in oriental medicine. | phototoxicity can be either harmful or beneficial. yet the phototoxicity of oriental medicinal plants is an understudied area. the purpose of this study is to fill in this gap. | 2010 | 19818392 |
| peroxyl radical scavenging capacity of extracts and isolated components from selected medicinal plants. | we determined the ability of extracts and active components isolated from nine medicinal plants, poncirus trifoliata, astragalus membranaceus, magnolia obovata, salvia miltiorrhiza, angelica dahurica, cornus officinalis, cnidium officinale, pueraria lobata and ostericum koreanum, to neutralize peroxyl radicals using the total oxyradical scavenging capacity (tosc) assay. peroxyl radicals were generated from thermal homolysis of 2,2'-azobis(2-methylpropionamidine) dihydrochloride, which oxidize al ... | 2010 | 20607491 |
| use of yokukansan (tj-54) in the treatment of neurological disorders: a review. | kampo herbal remedies are reported to have a wide range of indications and have attracted attention due to reports suggesting that these remedies are effective when used in disease treatment while maintaining a favourable quality of life. yokukansan, also known as tj-54, is composed of seven herbs; angelica acutiloba, atractylodes lancea, bupleurum falcatum, poria cocos, glycyrrhiza uralensis, cnidium officinale and uncaria rhynchophylla. yokukansan is used to treat insomnia and irritability as ... | 2010 | 20812276 |
| free radical scavenging activities of cnidium officinale makino and ligusticum chuanxiong hort. methanolic extracts. | antioxidants from natural resources possess multifaceted and importance of the activities provides substantial scope in neurodegenerative diseases. the aim of this study was to assess and compare the free radical scavenging activities of cnidium officinale and ligusticum chuanxiong, which are closely related species. | 2010 | 21120037 |
| a modified formulation of chinese traditional medicine improves memory impairment and reduces aß level in the tg-appswe/ps1de9 mouse model of alzheimer's disease. | ethnopharmacological relevance: suhexiang wan (shxw), a chinese traditional medicine has been used orally for the treatment of seizures, infantile convulsion, stroke and so forth. previously, we reported the effects of modified shxw essential oil mixture of the fragrance containing herbs on the sedative effect, anticonvulsant property and antioxidative activity after fragrance inhalation. materials and methods: this study was undertaken to evaluate beneficial effects of a modified recipe of shxw ... | 2011 | 21762767 |
| adulticidal activity of phthalides identified in cnidium officinale rhizome to b- and q-biotypes of bemisia tabaci. | the residual contact toxicity of three benzofuranoids (z)-butylidenephthalide (1), (3s)-butylphthalide (2), and (z)-ligustilide (3) identified in the rhizome of cnidium officinale (apiaceae) to b- and q-biotype females of bemisia tabaci was evaluated using a leaf-dip bioassay. results were compared with those of eight conventional insecticides. based on 24 h lc(50) values, (z)-butylidenephthalide (254 ppm) and (z)-ligustilide (268 ppm) were more toxic than (3s)-butylphthalide (339 ppm) against b ... | 2011 | 21728333 |
| Components of rhizome extract of Cnidium officinale Makino and their in vitro biological effects. | The anti-inflammatory and anticancer activities of a methanol extract of the rhizome of Cnidium officinale were investigated. Four compounds, namely falcarindiol (1), 6-hydroxy-7-methoxy-dihydroligustilide (2), ligustilidiol (3), and senkyunolide H (4) were isolated from the extract of the rhizome of Cnidium officinale and their structures were elucidated by analysis of their spectroscopic data and by comparison with previously reported data. These compounds showed anti-inflammatory activities, ... | 2011 | 22019572 |
| chemometric classification of morphologically similar umbelliferae medicinal herbs by dart-tof-ms fingerprint. | introduction: it needs many years of special training to gain expertise on the organoleptic classification of botanical raw materials and, for even those experts, discrimination among umbelliferae medicinal herbs remains an intricate challenge due to their morphological similarity. objective: to develop a new chemometric classification method using the direct analysis in real time-time of flight-mass spectrometry (dart-tof-ms) fingerprint for umbelliferae medicinal herbs and to provide a platfor ... | 2012 | 22271502 |
| effect of methanol extracts of cnidium officinale makino and capsella bursa-pastoris on the apoptosis of hsc-2 human oral cancer cells. | cnidium officinale makino and capsella bursa-pastoris are used as traditional herbs with diverse medicinal effects, including the inhibition of inflammation, reduction of blood pressure and as diuretics, however, the anti-cancer effects of c. officinale makino and c. bursa-pastoris are poorly defined. the aims of this study were to evaluate the effects of methanol extracts of c. officinale makino (meco) and methanol extracts of c. bursa-pastoris (mecb) on the cell growth and apoptosis of hsc-2 h ... | 2012 | 23403540 |
| metabolic profiling and identification of the genetic varieties and agricultural origin of cnidium officinale and ligusticum chuanxiong. | quality control methods for cnidium officinale and ligusticum chuanxiong are lacking because their quality is influenced by multiple factors. thus, there is a need to develop a multifactorial method for measuring quality that is both standardized and practical. here, we report a profiling method based on gas chromatography-mass spectrometry (gc-ms) to discriminate among the genetic varieties and agricultural origins of c. officinale and l. chuanxiong. our metabolome analysis identified 68 metabo ... | 2012 | 22627050 |
| food- and gender-dependent pharmacokinetics of paeoniflorin after oral administration with samul-tang in rats. | samul-tang (si-wu-tang in chinese, shimotsu-to in japanese), widely used in eastern asia, is composed of angelica gigas (angelicae gigantis radix), cnidium officinale (cnidii rhizoma), paeonia lactiflora (paeonia radix) and rehmannia glutinosa (rehmanniae radix preparata). paeoniflorin, one of active components in samul-tang has anti-platelet, anti-inflammation, anti-cancer and neuroprotective properties. however, there is no information about the effects of gender and food intake on the pharmac ... | 2012 | 22543167 |
| hemohim ameliorates the persistent down-regulation of th1-like immune responses in fractionated γ-irradiated mice by modulating the il-12p70-stat4 signaling pathway. | whole body irradiated mice appear to experience a down-regulation of the helper t (th)1-like immune response, and maintain a persistent immunological imbalance. in the current study, we evaluated the effect of hemohim (an herbal product made from angelica radix, cnidium officinale , and paeonia japonica cultivated in korea) to ameliorate the immunological imbalance induce in fractionated γ-irradiated mice. the mice were exposed to γ rays twice a week (0.5 gy fractions) for a total dose of 5 gy, ... | 2012 | 22439601 |
| ethanol extract of cnidium officinale exhibits anti-inflammatory effects in bv2 microglial cells by suppressing nf-κb nuclear translocation and the activation of the pi3k/akt signaling pathway. | chronic microglial activation endangers neuronal survival through the release of various toxic pro-inflammatory molecules; thus, negative regulators of microglial activation have been identified as potential therapeutic candidates for several neurological diseases. in this study, we investigated the inhibitory effects of an ethanol extract of cnidium officinale rhizomes (eeco), which has been used as a herbal drug in oriental medicine, on the production of lipopolysaccharide (lps)-induced pro-in ... | 2013 | 23864034 |
| preventative effect of an herbal preparation (hemohim) on development of airway inflammation in mice via modulation of th1/2 cells differentiation. | hemohim, an herbal preparation of three edible herbs (angelica gigas nakai, cnidium officinale makino, paeonia japonica miyabe) is known to increase the th1 immune response as well as reduce the allergic response in human mast cells. here, our goal was to determine whether or not hemohim could induce th1 cell differentiation as well as inhibit the development of airway inflammation. to study th1/th2 cell differentiation, naive cd4(+) t cells isolated from c57bl/6 mouse spleens were cultured with ... | 2013 | 23844220 |
| two novel talaromyces species isolated from medicinal crops in korea. | two novel biverticillate talaromyces species, t. angelicus and t. cnidii, were collected from the medicinal crops angelica gigas and cnidium officinale, respectively, in korea. phylogenetic analyses with the nuclear ribosomal internal transcribed spacer (its) region and the β-tubulin gene as well as morphological analyses revealed that the two species differ from any known talaromyces species. talaromyces angelicus is related to t. flavovirens in the phylogeny of the its region, but the new spec ... | 2013 | 24173649 |
| reactive oxygen species scavenging activity of jixueteng evaluated by electron spin resonance (esr) and photon emission. | jixueteng, the dried stem of spatholobus suberectus dunn (leguminosae), is a traditional chinese herbal medicine that is commonly classified as a herb that promotes blood circulation and can be used to treat blood stasis. the aim of this study was to examine the reactive oxygen species (ros) scavenging activity of jixueteng and other herbal medicines. the ros scavenging activities of the water extracts of jixueteng, cnidium officinale and salvia miltiorrhiza were examined using an electron spin ... | 2014 | 25632478 |
| immunomodulatory and antidiabetic effects of a new herbal preparation (hemohim) on streptozotocin-induced diabetic mice. | angelica gigas nakai, cnidium officinale makino, and paeonia japonica miyabe) was developed to protect immune, hematopoietic, and self-renewal tissues against radiation. this study determined whether or not hemohim could alter hyperglycemia and the immune response in diabetic mice. both nondiabetic and diabetic mice were orally administered hemohim (100 mg/kg) once a day for 4 weeks. diabetes was induced by single injection of streptozotocin (stz, 200 mg/kg, i.p.). in diabetic mice, hemohim effe ... | 2014 | 25045390 |
| anti cancer effects of cnidium officinale makino extract mediated through apoptosis and cell cycle arrest in the ht-29 human colorectal cancer cell line. | the anti cancer properties and underlying cell death mechanisms induced by an extract of the roots of cnidium officinale makino (com) were investigated. an ethanolic extract of com inhibited proliferation of human colon cancer cells (ht-29) with both dose- and time-dependence. analysis of the cell cycle after treatment of ht-29 cells with various concentrations of com showed reduction of cellular proliferation via g1 phase arrest. apoptotic effects of com and western blotting both revealed that ... | 2014 | 25040960 |
| z-ligustilide inhibits benzo(a)pyrene-induced cyp1a1 upregulation in cultured human keratinocytes via ros-dependent nrf2 activation. | benzo(a)pyrene (bap), a polycyclic aromatic hydrocarbon (pah), is an environmental contaminant that can induce cytochrome p4501a1 (cyp1a1) upregulation via aryl hydrocarbon receptor (ahr) activation and provoke inflammation. here, we investigated the effect of z-ligustilide, an active ingredient isolated from the medicinal plants cnidium officinale and angelica acutiloba, on bap-induced cyp1a1 upregulation in normal human epidermal keratinocytes (nheks) as well as its underlying mechanisms. z-li ... | 2014 | 24588654 |
| the complete genome sequences of two isolates of cnidium vein yellowing virus, a tentative new member of the family secoviridae. | we determined the complete genome sequences of two isolates of cnidium vein yellowing virus (cnvyv-1 and -2) that co-infected all field samples collected from cnidium officinale in korea. unlike cnvyv-2, however, cnvyv-1 was sap-transmissible to nicotiana benthamiana. cnvyv-1 and -2 have bipartite genomes of 7,263 and 3,110 nucleotides and 7,278 and 3,112 nucleotides, respectively, excluding the poly(a) tails. phylogenetic analysis of the cnvyv-1 and -2 sequences indicated close relationships to ... | 2015 | 26282235 |
| [assay of tetramethylpyrazine in szechwan lovage rhizome and cnidium rhizome by hplc-dad-ms]. | to quantity the amount of tetramethylpyrazine in szechwan lovage rhizome (chuanxiong, the rhizome of ligusticum chuanxiong hort., cx) and cnidium rhizome(japanese chuanxiong, the rhizome of cnidium officinale makino, jcx) for quality assessment. | 2015 | 26214868 |
| z-ligustilide ameliorated ultraviolet b-induced oxidative stress and inflammatory cytokine production in human keratinocytes through upregulation of nrf2/ho-1 and suppression of nf-κb pathway. | ultraviolet b (uvb), a harmful environmental factor, is responsible for a variety of skin disorders including skin inflammation through reactive oxygen species (ros) and inflammatory mediator production. here, we investigated the effect of z-ligustilide (z-lig), an active ingredient isolated from the medicinal plants cnidium officinale and angelica acutiloba, on uvb-induced ros generation and inflammatory mediator production in normal human epidermal keratinocytes (nheks) as well as its underlyi ... | 2015 | 25977183 |
| cnidilide, an alkylphthalide isolated from the roots of cnidium officinale, suppresses lps-induced no, pge2, il-1β, il-6 and tnf-α production by ap-1 and nf-κb inactivation in raw 264.7 macrophages. | cnidilide, an alkyl phthalide isolated from the rhizome of cnidium officinale, has been reported to possess antispasmodic and sedative effects. however, the anti-inflammatory capacity and molecular mechanism of cnidilide have not been studied to date. in the present study, we investigated the inhibitory effects of cnidilide on lps-induced pro-inflammatory mediators and the underlying molecular mechanisms in raw 264.7 macrophages. our results indicated that cnidilide potently inhibits inducible n ... | 2016 | 27591413 |
| cnidium officinale extract and butylidenephthalide inhibits retinal neovascularization in vitro and in vivo. | retinal neovascularization, which is the pathological growth of new blood vessels, is associated with retinopathy of prematurity, neovascular age-related macular degeneration, diabetic retinopathy and retinal vein occlusion. in this study, we evaluated the effect of an extract of cnidium officinale makino (coe) and its bioactive compound, butylidenephthalide (bp), on the migration and tube formation of human umbilical vein endothelial cells (huvecs), and on retinal pathogenic neovascularization ... | 2016 | 27435599 |
| fermented rice bran prevents atopic dermatitis in dncb-treated nc/nga mice. | the fermentation of natural plants has a favorable effect on the functional and biological activities of living systems. these include anti-oxidative, anti-inflammatory, and anti-platelet aggregation activities. this is attributed to the chemical conversion of the parent plants to functional constituents, which show more potent biological activity. in our study, rice bran along with oriental medicinal plants (angelicae gigantis, cnidium officinale, artemisia princeps, and camellia sinensis) was ... | 2016 | 27323667 |
| phthalides: distribution in nature, chemical reactivity, synthesis, and biological activity. | phthalides are a relatively small group of natural compounds confined to several plant families and some genera of fungi and liverworts. they are divided into two structural groups, the monomeric and dimeric phthalides, and known mainly as bioactive constituents of different plant species used traditionally for medicinal purposes in asia, europe, and north america.the first reports on the chemistry of phthalides appeared at the end of the nineteenth century, in which they were identified as the ... | 2017 | 28160212 |
| ameliorating effects of herbal formula hemomine on experimental subacute hemorrhagic anemia in rats. | hemomine (hm) is an herbal mixture consisting of 5 varieties of the hematopoietic herbal extracts (angelica gigas nakai, cnidium officinale makino, paeonia lactiflora pall., rehmannia glutinosa liboschitz ex stueudel, glycyrrhiza uralensis fischer). | 2017 | 28089715 |