Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| characterization of rhesus macaque b-lymphoblastoid cell lines infected with simian type d retrovirus. | a simian type d retrovirus designated srv induces a fatal immunosuppressive disease in rhesus macaques. this syndrome shows many clinical similarities to acquired immunodeficiency syndrome (aids) in human immunodeficiency virus-infected individuals. to investigate the mechanisms of immune dysfunction in srv infection, we have focused on the interactions of srv serotype 1 (srv-1) with macaque b-lymphoblastoid cell lines (b-lcl). procedures were optimized for establishing b-lcl by immortalization ... | 1991 | 1662056 |
| generation of macaque b lymphoblastoid cell lines with simian epstein-barr-like viruses: transformation procedure, characterization of the cell lines and occurrence of simian foamy virus. | two simian epstein-barr-like viruses, a rhesus epstein-barr virus and herpesvirus papio, were used to transform b cells from rhesus or cynomolgus macaques. the resulting cell lines exhibited predominantly a b lymphocyte phenotype and expressed epstein-barr virus antigens. the majority of b lymphoblastoid cell lines from macaques, which were seropositive for simian foamy virus, developed giant cells in culture. the cytopathic agent was identified as a foamy virus and was transmissible to human em ... | 1992 | 1331148 |
| squamous epithelial proliferative lesions associated with rhesus epstein-barr virus in simian immunodeficiency virus-infected rhesus monkeys. | proliferative lesions were found on the squamous epithelium of the tongue, esophagus, or penis or haired skin of the lip, hand, or thorax of 8 simian immunodeficiency virus-infected rhesus monkeys that died of simian aids. the lesions were focal and consisted of hyperkeratosis, parakeratosis, and acanthosis in the skin, with additional ballooning degeneration in the tongue, esophagus, and penis. the epithelial surfaces were frequently colonized by candida species or gram-positive cocci. intranuc ... | 1995 | 7622899 |
| comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian epstein-barr virus oncogene lmp1. | nonhuman primates are naturally infected with a b-lymphotropic herpesvirus closely related to epstein-barr virus (ebv). these simian ebv share considerable genetic, biologic, and epidemiologic features with human ebv, including virus-induced tumorigenesis. however, latent, transformation-associated viral genes demonstrate marked sequence divergence among species despite the conserved functions. we have cloned the latent membrane protein 1 (lmp1) homologs from the simian ebv naturally infecting b ... | 1996 | 8892903 |
| an animal model for acute and persistent epstein-barr virus infection. | epstein-barr virus (ebv) is a human lymphocryptovirus that causes infectious mononucleosis, persists asymptomatically for life in nearly all adults, and is associated with the development of b cell lymphomas and nasopharyngeal carcinomas. a highly similar rhesus lymphocryptovirus naturally endemic in rhesus monkeys was used to orally infect naïve animals from a pathogen-free colony. this animal model reproduced key aspects of human ebv infection, including oral transmission, atypical lymphocytos ... | 1997 | 9197263 |
| mechanisms that regulate epstein-barr virus ebna-1 gene transcription during restricted latency are conserved among lymphocryptoviruses of old world primates. | epstein-barr virus (ebv), the only known human lymphocryptovirus (lcv), displays a remarkable degree of genetic and biologic identity to lcvs that infect old world primates. within their natural hosts, infection by these viruses recapitulates many key aspects of ebv infection, including the establishment of long-term latency within b lymphocytes, and is therefore a potentially valuable animal model of ebv infection. however, it is unclear whether these lcvs have adopted or maintained the same me ... | 1999 | 9971778 |
| strong selective pressure for evolution of an epstein-barr virus lmp2b homologue in the rhesus lymphocryptovirus. | latent membrane protein 2b (lmp2b) is expressed during latent epstein-barr virus (ebv) infection, but little is known about its role. the goal of this study was to determine whether an lmp2b homologue is conserved in the rhesus monkey lymphocryptovirus (lcv). both rhesus lcv lmp2a and lmp2b genes were cloned and sequenced. the rhesus lcv lmp2b gene is positionally conserved, and the ebna-2 responsiveness and the bidirectional nature of the lmp1-lmp2b promoter have also been functionally conserve ... | 1999 | 10482645 |
| evolution of two types of rhesus lymphocryptovirus similar to type 1 and type 2 epstein-barr virus. | rhesus monkeys and other nonhuman old world primates are naturally infected with lymphocryptoviruses (lcv) that are closely related to epstein-barr virus (ebv). a rhesus lcv isolate (208-95) was derived from a b-cell lymphoma in a simian immunodeficiency virus-infected rhesus macaque. the ebna-2 homologues from 208-95 and a previous rhesus lcv isolate (lcl8664) were polymorphic on immunoblotting, so the ebna-2 genes from these two rhesus lcv were cloned, sequenced, and compared. the ebna-2 genes ... | 1999 | 10516028 |
| rhesus lymphocryptovirus infection during the progression of saids and saids-associated lymphoma in the rhesus macaque. | saids-associated lymphoma (sal) represents a monoclonal expansion of b-cell origin in which simian immunodeficiency virus (siv) infection is not detected. however, tumor cells are frequently infected with rhesus lymphocryptovirus (rhlcv), a rhesus homologue of epstein-barr virus (ebv). in previous studies, the incidence of rhlcv infection in sal was determined to be 89% as measured by polymerase chain reaction (pcr) and/or in situ hybridization. the main objective of the present study was to asc ... | 2000 | 10659055 |
| structural, functional, and genetic comparisons of epstein-barr virus nuclear antigen 3a, 3b, and 3c homologues encoded by the rhesus lymphocryptovirus. | ebna-3a, -3b, and -3c are three latent infection nuclear proteins important for epstein-barr virus (ebv)-induced b-cell immortalization and the immune response to ebv infection. all three are hypothesized to function as transcriptional transactivators, but little is known about their precise mechanism of action or their role in ebv pathogenesis. we have cloned and studied the three ebna-3 homologues from a closely related lymphocryptovirus (lcv) which naturally infects rhesus monkeys. the rhesus ... | 2000 | 10846073 |
| cloning of the rhesus lymphocryptovirus viral capsid antigen and epstein-barr virus-encoded small rna homologues and use in diagnosis of acute and persistent infections. | epstein-barr virus (ebv) is the most common cause of infectious mononucleosis and is associated with the development of several human malignancies. a closely related herpesvirus in the same lymphocryptovirus (lcv) genera as ebv naturally infects rhesus monkeys and provides an important animal model for studying ebv pathogenesis. we cloned the small viral capsid antigen (svca) homologue from the rhesus lcv and developed a peptide enzyme-linked immunosorbent assay (elisa) to determine whether epit ... | 2000 | 10970361 |
| complete nucleotide sequence of the rhesus lymphocryptovirus: genetic validation for an epstein-barr virus animal model. | we sequenced the rhesus lymphocryptovirus (lcv) genome in order to determine its genetic similarity to epstein-barr virus (ebv). the rhesus lcv encodes a repertoire identical to that of ebv, with 80 open reading frames, including cellular interleukin-10, bcl-2, and colony-stimulating factor 1 receptor homologues and an equivalent set of viral glycoproteins. the highly conserved rhesus lcv gene repertoire provides a unique animal model for the study of ebv pathogenesis. | 2002 | 11739708 |
| siv-associated lymphomas in rhesus monkeys (macaca mulatta) in comparison with hiv-associated lymphomas. | a retrospective study was performed to characterize malignant lymphomas of 16 simian immunodeficiency virus (siv)-infected rhesus monkeys (macaca mulatta), 2-9 years of age, on the basis of clinical data, histologic and immunophenotypic results, and cell death indices compiled with the tdt-mediated x-dutp nick end labeling method. we particularly focused on providing immunohistochemical evidence of expression products of ebna2, bc12, c-myc, p21, p53, and bc16. results were compared with data fro ... | 2002 | 12102218 |
| molecular evidence for rhesus lymphocryptovirus infection of epithelial cells in immunosuppressed rhesus macaques. | epstein-barr virus (ebv) is a human oncogenic herpesvirus associated with epithelial cell and b-cell malignancies. ebv infection of b lymphocytes is essential for acute and persistent ebv infection in humans; however, the role of epithelial cell infection in the normal ebv life cycle remains controversial. the rhesus lymphocryptovirus (lcv) is an ebv-related herpesvirus that naturally infects rhesus macaques and can be used experimentally to model persistent b-cell infection and b-cell lymphomag ... | 2004 | 15016868 |
| experimental rhesus lymphocryptovirus infection in immunosuppressed macaques: an animal model for epstein-barr virus pathogenesis in the immunosuppressed host. | to develop a model for epstein-barr virus (ebv) pathogenesis in immunosuppressed hosts, we studied experimental infections of immunocompetent versus shiv 89.6p-infected, immunosuppressed rhesus macaques with the ebv-related rhesus lymphocryptovirus (lcv). primary lcv infection after oral inoculation of 4 immunocompetent animals was characterized by an acute viremia and seroconversion followed by asymptomatic lcv persistence. four immunosuppressed macaques infected orally with lcv failed to devel ... | 2004 | 15150077 |
| mutations of epstein-barr virus gh that are differentially able to support fusion with b cells or epithelial cells. | the core fusion machinery of all herpesviruses consists of three conserved glycoproteins, gb and ghgl, suggesting a common mechanism for virus cell fusion, but fusion of epstein-barr virus (ebv) with b cells and epithelial cells is initiated differently. fusion with b cells requires a fourth protein, gp42, which complexes with ghgl and interacts with hla class ii, the b-cell coreceptor. fusion with an epithelial cell does not require gp42 but requires interaction of ghgl with a novel epithelial ... | 2005 | 16103144 |
| conserved cell cycle regulatory properties within the amino terminal domain of the epstein-barr virus nuclear antigen 3c. | the gammaherpesviruses rhesus lymphocryptovirus (lcv) and epstein-barr virus (ebv) are closely related phylogenetically. rhesus lcv efficiently immortalizes rhesus b cells in vitro. however, despite a high degree of conservation between the rhesus lcv and ebv genomes, rhesus lcv fails to immortalize human b cells in vitro. this species restriction may, at least in part, be linked to the ebv nuclear antigens (ebnas) and latent membrane proteins (lmps), known to be essential for b cell transformat ... | 2006 | 16364389 |
| the bzlf1 homolog of an epstein-barr-related gamma-herpesvirus is a frequent target of the ctl response in persistently infected rhesus macaques. | although cd8(+) t lymphocytes targeting lytic infection proteins dominate the immune response to acute and persistent ebv infection, their role in immune control of ebv replication is not known. rhesus lymphocryptovirus (rhlcv) is a gamma-herpesvirus closely related to ebv, which establishes persistent infection in rhesus macaques. in this study, we investigated cellular immune responses to the rhlcv bzlf1 (rhbzlf1) homolog in a cohort of rhlcv-seropositive rhesus macaques. rhbzlf1-specific ifn- ... | 2006 | 16517707 |
| epstein-barr virus micrornas are evolutionarily conserved and differentially expressed. | the pathogenic lymphocryptovirus epstein-barr virus (ebv) is shown to express at least 17 distinct micrornas (mirnas) in latently infected cells. these are arranged in two clusters: 14 mirnas are located in the introns of the viral bart gene while three are located adjacent to bhrf1. the bart mirnas are expressed at high levels in latently infected epithelial cells and at lower, albeit detectable, levels in b cells. in contrast to the tissue-specific expression pattern of the bart mirnas, the bh ... | 2006 | 16557291 |
| ebna-3b- and ebna-3c-regulated cellular genes in epstein-barr virus-immortalized lymphoblastoid cell lines. | the cellular pathways that epstein-barr virus (ebv) manipulates in order to effect its lifelong persistence within hosts and facilitate its transmission between hosts are not well understood. the ebv nuclear antigen 3 (ebna-3) family of latent infection proteins consists of transcriptional regulators that influence viral and cellular gene expression in ebv-infected cells. to identify ebna-3b- and ebna-3c-regulated cellular genes potentially important for virus infection in vivo, we studied a lym ... | 2006 | 17005691 |
| epstein-barr virus thymidine kinase is a centrosomal resident precisely localized to the periphery of centrioles. | the thymidine kinase (tk) encoded by epstein-barr virus (ebv) differs not only from that of the alphaherpesviruses but also from that of the gamma-2 herpesvirus subfamily. because cellular location is frequently a determinant of regulatory function, to gain insight into additional role(s) of ebv tk and to uncover how the lymphocryptovirus and rhadinovirus enzymes differ, the subcellular localizations of ebv tk and the related cercopithecine herpesvirus-15 tk were investigated. we show that in co ... | 2007 | 17428875 |
| compatibility of the gh homologues of epstein-barr virus and related lymphocryptoviruses. | glycoprotein gh, together with its chaperone gl and a third glycoprotein gb, is essential for cell-cell fusion and virus-cell fusion mediated by herpesviruses. epstein-barr virus (ebv), the prototype human lymphocryptovirus, requires a fourth glycoprotein gp42 to support fusion with b cells in addition to epithelial cells. two other lymphocryptoviruses, the rhesus lymphocryptovirus (rh-lcv) and the common marmoset lymphocryptovirus (calhv3), have been sequenced in their entirety and each has a g ... | 2007 | 17622614 |
| rhesus lymphocryptovirus latent membrane protein 2a activates beta-catenin signaling and inhibits differentiation in epithelial cells. | rhesus lymphocryptovirus (lcv) is a gamma-herpesvirus closely related to epstein-barr virus (ebv). the rhesus latent membrane protein 2a (lmp2a) is highly homologous to ebv lmp2a. ebv lmp2a activates the phosphatidylinositol 3-kinase (pi3k) and beta-catenin signaling pathways in epithelial cells and affects differentiation. in the present study, the biochemical and biological properties of rhesus lmp2a in epithelial cells were investigated. the expression of rhesus lmp2a in epithelial cells indu ... | 2008 | 18570966 |
| rhesus lymphocryptovirus type 1-associated b-cell nasal lymphoma in siv-infected rhesus macaques. | epstein-barr virus (ebv) is a worldwide endemic gamma herpesvirus of the genus lymphocryptovirus (lcv) that infects more than 90% of the world's population. ebv has been associated with a variety of malignancies, but it has a demonstrated role in lymphomas, especially in immunosuppressed individuals. lymphomas of the nasal cavity, paranasal sinuses, and nasopharynx are uncommon and constitute less than 5% of all extranodal lymphomas. sinonasal non-hodgkin's lymphomas have been reported in patien ... | 2008 | 18984796 |
| identifying sites bound by epstein-barr virus nuclear antigen 1 (ebna1) in the human genome: defining a position-weighted matrix to predict sites bound by ebna1 in viral genomes. | we identified binding sites for epstein-barr virus (ebv) nuclear antigen 1 (ebna1) in the human genome using chromatin immunoprecipitation and microarrays. the sequences for these newly identified sites were used to generate a position-weighted matrix (pwm) for ebna1's dna-binding sites. this pwm helped identify additional dna-binding sites for ebna1 in the genomes of ebv, kaposi's sarcoma-associated herpesvirus, and cercopithecine herpesvirus 15 (cehv-15) (also called herpesvirus papio 15). in ... | 2009 | 19129441 |
| functional analysis of glycoprotein l (gl) from rhesus lymphocryptovirus in epstein-barr virus-mediated cell fusion indicates a direct role of gl in gb-induced membrane fusion. | glycoprotein l (gl), which complexes with gh, is a conserved herpesvirus protein that is essential for epstein-barr virus (ebv) entry into host cells. the gh/gl complex has a conserved role in entry among herpesviruses, yet the mechanism is not clear. to gain a better understanding of the role of gl in ebv-mediated fusion, chimeric proteins were made using rhesus lymphocryptovirus (rh-lcv) gl (rh gl), which shares a high sequence homology with ebv gl but does not complement ebv gl in mediating f ... | 2009 | 19457993 |
| expression and processing of a small nucleolar rna from the epstein-barr virus genome. | small nucleolar rnas (snornas) are localized within the nucleolus, a sub-nuclear compartment, in which they guide ribosomal or spliceosomal rna modifications, respectively. up until now, snornas have only been identified in eukaryal and archaeal genomes, but are notably absent in bacteria. by screening b lymphocytes for expression of non-coding rnas (ncrnas) induced by the epstein-barr virus (ebv), we here report, for the first time, the identification of a snorna gene within a viral genome, des ... | 2009 | 19680535 |
| a global analysis of evolutionary conservation among known and predicted gammaherpesvirus micrornas. | micrornas (mirnas) are small, noncoding rnas which posttranscriptionally regulate gene expression. the current release of the mirna registry lists 16 viruses which encode a total of 146 mirna hairpins. strikingly, 139 of these are encoded by members of the herpesvirus family, suggesting an important role for mirnas in the herpesvirus life cycle. however, with the exception of 7 mirna hairpins known to be shared by epstein-barr virus (ebv) and the closely related rhesus lymphocryptovirus (rlcv), ... | 2010 | 19889779 |
| comprehensive analysis of rhesus lymphocryptovirus microrna expression. | rhesus lymphocryptovirus (rlcv) and epstein-barr virus (ebv) are closely related gammaherpesviruses that infect and cause disease in rhesus monkeys and humans, respectively. thus, rlcv is an important model system for ebv pathogenesis. both rlcv and ebv express micrornas (mirnas), several conserved in sequence and genomic location. we have applied deep sequencing technology to obtain an inventory of rlcv mirna expression in latently rlcv-infected monkey b cells. our data confirm the presence of ... | 2010 | 20219930 |
| systemic spironucleosis in 2 immunodeficient rhesus macaques (macaca mulatta). | spironucleus spp are parasites of fish and terrestrial vertebrates, including mice and turkeys, that rarely cause extraintestinal disease. two rhesus macaques (macaca mulatta) were experimentally inoculated with simian immunodeficiency virus mac251. both progressed to simian acquired immune deficiency syndrome within 1 year of inoculation and developed systemic protozoal infections in addition to common opportunistic infections, including rhesus cytomegalovirus, rhesus lymphocryptovirus, and rhe ... | 2010 | 20351359 |
| cloning of the epstein-barr virus-related rhesus lymphocryptovirus as a bacterial artificial chromosome: a loss-of-function mutation of the rhbarf1 immune evasion gene. | rhesus macaques are naturally infected with a gammaherpesvirus which is in the same lymphocryptovirus (lcv) genus as and closely related to epstein-barr virus (ebv). the rhesus macaque lcv (rhlcv) contains a repertoire of genes identical to that of ebv, and experimental rhlcv infection of naive rhesus macaques accurately models acute and persistent ebv infection of humans. we cloned the lcl8664 rhlcv strain as a bacterial artificial chromosome to create recombinant rhlcv for investigation in thi ... | 2010 | 21084476 |
| mapping regions of epstein-barr virus (ebv) glycoprotein b (gb) important for fusion function with gh/gl. | glycoproteins gb and gh/gl are required for entry of epstein-barr virus (ebv) into cells, but the role of each glycoprotein and how they function together to mediate fusion is unclear. analysis of the functional homology of gb from the closely related primate gammaherpesvirus, rhesus lymphocryptovirus (rh-lcv), showed that ebv gb could not complement rh gb due to a species-specific dependence between gb and gl. to map domains of gb required for this interaction, we constructed a panel of ebv/rh ... | 2011 | 21376360 |
| Antibodies to lytic infection proteins in lymphocryptovirus-infected rhesus macaques: a model for humoral immune responses to epstein-barr virus infection. | Humoral immune responses to rhesus lymphocryptovirus (rhLCV) lytic infection proteins were evaluated in the rhesus macaque animal model for Epstein-Barr virus (EBV) infection. We found a hierarchy of humoral responses to 14 rhLCV lytic infection proteins in naturally infected rhesus macaques, with (i) widespread and robust responses to four glycoproteins expressed as late proteins, (ii) frequent but less robust responses to a subset of early proteins, and (iii) low-level responses to immediate-e ... | 2011 | 21734064 |
| Soluble rhesus lymphocryptovirus gp350 protects against infection and reduces viral loads in animals that become infected with virus after challenge. | Epstein-Barr virus (EBV) is a human lymphocryptovirus that is associated with several malignancies. Elevated EBV DNA in the blood is observed in transplant recipients prior to, and at the time of post-transplant lymphoproliferative disease; thus, a vaccine that either prevents EBV infection or lowers the viral load might reduce certain EBV malignancies. Two major approaches have been suggested for an EBV vaccine- immunization with either EBV glycoprotein 350 (gp350) or EBV latency proteins (e.g. ... | 2011 | 22028652 |
| therapeutic vaccination against the rhesus lymphocryptovirus ebna-1 homologue, rhebna-1, elicits t cell responses to novel epitopes in rhesus macaques. | epstein-barr virus (ebv) is a vaccine/immunotherapy target due to its association with several human malignancies. ebna-1 is an ebv protein consistently expressed in all ebv-associated cancers. herein, ebna-1-specific t cell epitopes were evaluated after adc-rhebna-1 immunizations in chronically lymphocryptovirus-infected rhesus macaques, an ebv infection model. preexisting rhebna-1-specific responses were augmented in 4/12 animals, and new epitopes were recognized in 5/12 animals after vaccinat ... | 2013 | 24089556 |
| genome-wide analyses of epstein-barr virus reveal conserved rna structures and a novel stable intronic sequence rna. | epstein-barr virus (ebv) is a human herpesvirus implicated in cancer and autoimmune disorders. little is known concerning the roles of rna structure in this important human pathogen. this study provides the first comprehensive genome-wide survey of rna and rna structure in ebv. | 2013 | 23937650 |
| cd4+ and cd8+ t-cell responses to latent antigen ebna-1 and lytic antigen bzlf-1 during persistent lymphocryptovirus infection of rhesus macaques. | epstein-barr virus (ebv) infection leads to lifelong viral persistence through its latency in b cells. ebv-specific t cells control reactivations and prevent the development of ebv-associated malignancies in most healthy carriers, but infection can sometimes cause chronic disease and malignant transformation. epstein-barr nuclear antigen 1 (ebna-1) is the only viral protein consistently expressed during all forms of latency and in all ebv-associated malignancies and is a promising target for a t ... | 2013 | 23698300 |
| atypical nodular astrocytosis in simian immunodeficiency virus-infected rhesus macaques (macaca mulatta). | simian immunodeficiency virus (siv), a model for hiv pathogenesis, is associated with neuropathology. | 2014 | 25082291 |
| evolutionary conservation of primate lymphocryptovirus microrna targets. | epstein-barr virus (ebv) and rhesus lymphocryptovirus (rlcv) are closely related gammaherpesviruses in the lymphocryptovirus subgroup that express viral micrornas (mirnas) during latent infection. in addition to many host mrnas, ebv mirnas are known to target latent viral transcripts, specifically those encoding lmp1, bhrf1, and ebna2. the mrna targets of rlcv mirnas have not been investigated. using luciferase reporter assays, photoactivatable cross-linking and immunoprecipitation (par-clip), a ... | 2014 | 24257599 |
| adenovirus-based vaccines against rhesus lymphocryptovirus ebna-1 induce expansion of specific cd8+ and cd4+ t cells in persistently infected rhesus macaques. | the impact of epstein-barr virus (ebv) on human health is substantial, but vaccines that prevent primary ebv infections or treat ebv-associated diseases are not yet available. the epstein-barr nuclear antigen 1 (ebna-1) is an important target for vaccination because it is the only protein expressed in all ebv-associated malignancies. we have designed and tested two therapeutic ebv vaccines that target the rhesus (rh) lymphocryptovirus (lcv) ebna-1 to determine if ongoing t cell responses during ... | 2014 | 24522914 |
| epstein-barr virus gp350 can functionally replace the rhesus lymphocryptovirus major membrane glycoprotein and does not restrict infection of rhesus macaques. | primary epstein-barr virus (ebv) infection is the most common cause of infectious mononucleosis, and persistent infection is associated with multiple cancers. ebv vaccine development has focused on the major membrane glycoprotein, gp350, since it is the major target for antibodies that neutralize infection of b cells. however, ebv has tropism for both b cells and epithelial cells, and it is unknown whether serum neutralizing antibodies against b cell infection will provide sufficient protection ... | 2015 | 26559839 |
| pan-viral-microrna screening identifies interferon inhibition as a common function of diverse viruses. | diverse viruses encode regulatory rnas called micrornas (mirnas). despite much progress, the functions of the majority of viral mirnas remain unknown. most previous studies have used biochemical methods to uncover targets of viral mirnas, but it is unclear what fraction of these targets is functionally important. here, we apply an alternative strategy based on the premise that assorted viral mirnas will share functionality. screening a library of >70 human viral mirnas showed that three unrelate ... | 2015 | 25624489 |
| gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with siv or shiv. | human gammaherpesviruses are associated with malignancies in hiv infected individuals; in macaques used in non-human primate models of hiv infection, gammaherpesvirus infections also occur. limited data on prevalence and tumorigenicity of macaque gammaherpesviruses, mostly cross-sectional analyses of small series, are available. we comprehensively examine all three-rhesus macaque gammaherpesviruses -rhesus rhadinovirus (rrv), rhesus lymphocryptovirus (rlcv) and retroperitoneal fibromatosis herpe ... | 2018 | 30001436 |
| neutralizing antibodies protect against oral transmission of lymphocryptovirus. | epstein-barr virus (ebv) is a cancer-associated pathogen for which there is no vaccine. successful anti-viral vaccines elicit antibodies that neutralize infectivity; however, it is unknown whether neutralizing antibodies prevent ebv acquisition. here we assessed whether passively delivered ammo1, a monoclonal antibody that neutralizes ebv in a cell-type-independent manner, could protect against experimental ebv challenge in two animal infection models. when present prior to a high-dose intraveno ... | 2020 | 32724901 |