Publications

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[further studies on the biology of strongylus vulgaris (nematodes) in the host]. 195114837165
[on morphology of strongylus vulgaris (nematoda)]. 195214951659
[spinal nematodosis in the horse caused by strongylus vulgaris]. 19655895489
studies on pathological lesions due to strongylus vulgaris infection in an indian pony. 19666009405
obliquely striated muscle : iv. sarcoplasmic reticulum, contractile apparatus, and endomysium of the body muscle of a polychaete, glycera, in relation to its speed.body muscle cells of the bloodworm glycera, a polychaete annelid, were studied by electron microscopy and compared with muscle cells of the more slowly acting nematode ascaris, which have been described previously. both muscles are obliquely striated. the predominant type of bloodworm fiber is characterized by a prominent transversely oriented sarcoplasmic reticulum with numerous dyads at the surface of each cell. thick myofilaments are approximately 3 micro long and overlap along approximately ...196819866720
the isolation and maintenance of a monospecific infection of strongylus vulgaris in the horse. 19715542322
heterogeneity of the hemoglobin from the common bloodworm glycera dibranchiata. 19715547700
the role of ultrastructure and physiological differentiation of epithelia in amino acid uptake by the bloodworm, glycera. 19725021125
the amino acid sequence of the monomeric hemoglobin component from the bloodworm, glyat liver. 19725063466
the life cycle of strongylus vulgaris in the horse. 19725072578
the structures of lamprey and bloodworm hemoglobins in relation to their evolution and function. 19724508148
fine structure of erythrocytes of the common bloodworm glycera dibranchiata. 19724649372
further observations on the maintenance of a monospecific infection of strongylus vulgaris in the horse. 19734721941
the kikuchi--enigk model of strongylus vulgaris migrations in the horse. 19734574177
host response to experimentally induced infections of strongylus vulgaris in parasite-free and naturally infected ponies. 19744417305
verminous encephalitis of horses: experimental induction with strongylus vulgaris larvae. 19744433067
strongylus vulgaris infection in the horse. 19744446282
critical tests of suspension, paste, and pellet formulations of cambendazole in the horse.three formulations of cambendazole were evaluated for anthelmintic activity by critical testing method in 21 horses. cambendazole suspension was administered via stomach tube at the dose rate of 10 mg/kg to 3 horses and at the dose rate of 20 mg/kg to 3 horses. cambendazole paste was given intraorally to 8 horses, and the pellet formulation was fed to 7 horses at the dose rate of 20 mg/kg. anthelmintic activity of cambendazole was similar for all dose rates and formulations. gasterophilus intest ...1975123710
osmotic responses of the bloodworm glycera dibranchiata ehlers: a graphical approach to the analysis of weight regulation. 1975240565
[granulomatous lymphadenitis in a horse due to 4th stage larvae of strongylus vulgaris]. 19751115742
the pathogenesis of single experimental infections with strongylus vulgaris in foals.the clinical signs, pathology and clinical pathology associated with single experimental infections of strongylus vulgaris in worm-free pony foals are described. the major clinical signs which became apparent in the infected foals during the first three weeks were pyrexia, anorexia, dullness and abdominal pain. within the first two weeks of infection lesions were confined to the intestine and terminal branches of the intestinal arteries and consisted of mucosal, submucosal and serosal haemorrhag ...19751118668
studies on the epidemiology of strongylus vulgaris infection of the horse. 19751140880
strongylus vulgaris-the horse killer. 19751143279
diarrhoea in horses associated with ulceration of the colon and caecum resulting from s vulgaris larval migration.the clinical manifestations of a diarrhoeic syndrome of horses with ulceration of the mucosae of the colon and caecum are described. patients could be divided into three groups according to their presenting symptoms and the disease is probably caused by the thrombo-embolism associated with migrating larvae of strongylus vulgaris. the differential diagnosis, prognosis and treatment are outlined with particular reference to the use of antithrombotic agents.19751162877
the pathogenesis and control of strongyle infection in the horse.the migratory route of infective strongylus vulgaris larvae was determined: penetration of small and large intestine into the lumina of submucosal arteries, migration up the arterial tree, reaching the cranial mesenteric site by three weeks, where the larvae develop to the mature 4th stage. after 3-4 months they exsheath and the young adults migrate down the arteries towards the intestines, to the limit of arterial narrowing, from where they rupture from nodules into the lumen of the intestine. ...19751177246
[arterial repair after mechanical injury by migrating fourth-stage larvae of strongylus vulgaris in the horse (a light and electron microscopic study) (author's transl)].introduction: migrating fourth-stage larvae of strongylus vulgaris, a parasite of equines, damage the intima of the anterior mesenteric artery and its larger branches and induce thrombus formation on the injured sites. as the time of larval passage through each of these branches has been exactly determined in earlier experiments, the aim of the present studies is to contribute to a more complete understanding of repair mechanisms in the process of time after thrombotic vascular injuries. materia ...19751180809
oxibendazole: critical anthelmintic trials in equids.the efficacy of oxibendazole against gastrointestinal parasites of horses was evaluated by the critical test method. naturally infected ponies of various ages were given single oral doses of 5, 10, or 15 mg-kg of bodyweight. the drug was highly effective against adult large strongylids (strongylus vulgaris, s edentatus, s equins), adult small strongylids (especially species of the genera cylicostephanus, cylicocyclus, cyaathostomum, and triodontophorus), and adult and larval stages of the large ...19751216434
heterogeneity and oxygen equilibria of haemoglobin from the bloodworm glycera gigantea. 19761248215
critical tests and safety studies on trichlorfon as an antiparasitic agent in the horse.three series of critical tests were completed on a combined total of 46 horses to determine the efficacy of single doses of trichlorfon against bots, ascarids, pinworms, and large strongyles. different formulations of trichlorfon were administered by tubing intragastrically, mixing with the daily grain ration, injecting intramuscularly, or pouring on the back at dose rates between 20 and 100 mg/kg. administration by feeding tended to be more efficacious for removal of bots and less toxic to the ...19761259212
strongylus vulgaris in the horse: a review. 1976779947
critical tests of anthelmintic activity of a paste formulation of thiabendazole in horses.critical tests of the activity on large strongyles, ascarids, mature pinworms, and bots were carried out in 11 horses intraorally treated with a paste formulation of thiabendazole. the dose level of 44 mg/kg was administered to 3 horses, and the dose level of 88 mg/kg to 8 horses. removals of strongylus vulgaris and mature oxyuris equi were 100% at the 2 dose levels, and efficacy against strongylus edentatus varied from 95 to 99% and 89 to 100% for the 44- and the 88-mg/kg dose levels, respectiv ...1976937790
eimeria leuckarti infection in foals.this is the first report on eimeria leuckarti infection in foals in japan. seven thoroughbred or angloarabian foals 2 to 7 months of age raised in the hidaka district, hokkaido, were infected with e. leuckarti. they died of severe alterations caused by the larval migration of strongylus vulgaris, and were examined over a period from 1970 to 1973. protozoa of this species were observed in the small intestine in all the foals. they were found mostly in vacuoles of the cytoplasm of monoclear cells ...1976950993
arteriography in ponies with strongylus vulgaris arteritis.radiographs of the aorta and abdominal arteries were obtained from a normal anesthetized pony following catheterization of a femoral artery for nonselective, semiselective or selective arteriography. the arteries had smooth borders and regular diameters and the branches of the cranial mesenteric artery could be followed distally on the angiogram through to the smaller branches proximal to the bowel wall. following arteriography, the pony walked normally and there were minimal alterations of the ...1977861832
an evaluation of ethyl-6-ethoxybenzothiazole-2-carbamate (sch 18099) for anthelmintic activity in domestic animals.ethyl-6-ethoxybenzothiazole-2-carbamate (sch 18099) was evaluated for efficacy against natural helminth infections in ponies, pigs, lambs and chickens. sixteen critical trials were conducted in ponies at dosages of 15 to 150 mg/kg. at 15 mg/kg, efficacy against adult and larval oxyuris equi was 100% and 91% and against small strongyles it was 98%. efficacy levels were 95% against strongylus vulgaris and s. edentatus at the 20 mg/kg dosage. in two trials at 100 mg/kg efficacy against parascaris e ...1977864223
critical tests of the antiparasitic activity of thiabendazole and trichlorfon sequentially administered to horses via stomach tube.thirteen critical tests were conducted in horses naturally infected with helminths and bots. single doses of thiabendazole (44 mg/kg of body weight) and trichlorfon (40 mg/kg of body weight) powder formulations were administered as suspensions sequentially given via stomach tube to evaluate the efficacy of the combination against the large parasites of horses. parasite removal efficacies were 100% against 2nd instar gasterophilus intestinalis and 2nd and 3rd instar gasterophilus nasalis and 82 t ...1977879569
critical anthelmintic trials in ponies with four benzimidazoles: mebendazole, cambendazole, fenbendazole, and albendazole.the comparative efficacy of four benzimidazoles against gastrointestinal parasites of ponies was evaluated by the critical test method. mebendazole (8.8 mg/kg), cambendazole (20 mg/kg), fenbendazole (5 mg/kg), and albendazole (2.5 and 5 mg/kg) given in single oral doses were highly effective against adult large strongylids (strongylus vulgaris, s. endentatus, s. equinus) and adult small strongylids (genera identified in order of frequency: cylicostephanus, cylicocyclus, cyathostomum, triodontoph ...1977886410
the efficacy of fenbendazole in the control of immature strongyle infections in ponies.the efficacy of fenbendazole against immature stages of trichonema spp., strongylus vulgaris and strongylus edentatus was evaluated. naturally infected 6 to 12 month old ponies were given single, oral doses of 0, 15, 30 and 60 mg/kg of body weight. a dose response relationship was noted between increasing dose levels and efficiency against larval trichonemes and migrating stages of s. vulgaris and s. edentatus. dose levels of 30 mg/kg and higher removed 93 per cent of mucosal stages of trichonem ...1977560964
diagnosis and treatment of "verminous aneurysm" formation in the horse.the clinical manifestations, diagnosis and differential diagnosis of "verminous aneurysm" formation at the root of the cranial mesenteric artery and coeliac artery resulting from strongylus vulgaris larvae migration are described. forty-nine of 57 cases were successfully treated with low molecular weight dextran (dextran 70).1977579006
clinical response of pony foals experimentally infected with strongylus vulgaris. 1977596704
critical tests of the anthelmintic febantel in the horse: activity of a paste formulation alone or with a trichlorfon paste.critical tests were carried out in 10 horses to evaluate the antiparasitic activity of febantel given alone or with trichlorfon. paste formulations were administered intraorally at dose levels of 6 mg of febantel (active ingredient)/kg and 35 mg of trichlorfon (active ingredient)/kg. in 5 tests with febantel alone, removal of 100% was recorded for mature or immature parascaris equorum from 2 infected horses. strongylus vulgaris from 4 infected horses, s edentatus from 5 infected horses, and matu ...1978697152
an evaluation of the efficacy of oxfendazole against the common nematode parasites of the horse.in a controlled trial in naturally-infected young ponies, oxfendazole administered orally at dose-rates of 10 mg per kg and 50 mg per kg resulted in complete elimination of trichostrongylus axei, parascaris equorum, oxyuris equi and adult strongylus vulgaris. also, all migrating strongylus edentatus larvae recovered from the subperitoneal tissues of the flank were found to be dead. minimum efficiencies of 99.8 per cent and 99.1 per cent were obtained against adult small strongyles (trichonema sp ...1978364817
increase of immunoglobulin t concentration in ponies as a response to experimental infection with the nematode strongylus vulgaris. 197875703
clinical aspects of strongylus vulgaris infection in the horse. emphasis on diagnosis, chemotherapy, and prophylaxis. 1979399708
critical test evaluation of butamisole against gastrointestinal parasites of horses and ponies.a critical test was performed to evaluate the anthelmintic properties of an injectable butamisole formulation and to compare the efficiency with that of a commercially available piperazine-thiabendazole anthelmintic. the test was done in 10 horses and 15 ponies with naturally acquired parasitic infections. butamisole was administered at the dose level of 2.5 or 3.75 mg/kg of body weight by either subcutaneous or deep intramuscular injection. given at the dose level of 2.5 mg/kg, butamisole was h ...1979453676
critical anthelmintic trials in ponies with oxfendazole and caviphos and concomitant studies on the spontaneous elimination of small strongylids.the efficacy of the benzimidazole, oxfendazole, and the organophosphate, caviphos, against gastrointestinal parasites of ponies was evaluated by the critcial test method. oxfendazole (10 mg/kg of body weight) given in single oral doses was 100% effective against adult large strongylids (strongylus vulgaris, strongylus edentatus, and strongylus equinus), 99% effective against adult small strongylids, and 97% effective against 4th-stage small strongylids (genera identified in order of frequency: c ...1979475090
[verminous enteritis and thrombo-embolic colic in the horse. a description of 36 cases (author's transl)].based upon case reports from 36 cases of verminous thrombosis of arteria mesenterica cranialis--all of which were verified at necropsy--clinical symptoms, course and pathological lesions are described. seventy five per cent of the patients were under 3 years old, and 73% of the cases showed initial signs during the period july-december. salient clinical findings were, unthrifty appearance and emaciation, diarrhoea--observed in two thirds of the patients--and colic--observed in 50 per cent of the ...1979492971
benzimidazole resistance of equine stronygles--critical tests of six compounds against population b.critical tests were conducted on eight horses naturally infected with several species of large and small strongyles from population b. tested were six benzimidazoles, including thiabendazole (2 lots) (44 mg/kg of body weight); mebendazole (8.8 mg/kg); cambendazole (two formulations) (20 mg/kg); fenbendazole (10 mg/kg); oxibendazole (10 mg/kg); and oxfendazole (10 mg/kg). all compounds were administered by stomach tube except one of the two cambendazole formulations which was an intraoral paste. ...1979517836
the epidemiology of equine strongylosis in southern queensland. 3. seasonal variation in arterial populations of strongylus vulgaris, and the prevalence of some helminths.the anterior mesenteric arteries of 138 horses slaughtered in southern queensland were examined for the presence of s. vulgaris larvae. seasonal differences were noted in the size of arterial populations of this parasite, with higher mean monthly numbers of worms per horse occurring in winter. there was an equally high incidence of severe verminous arteritis during the winter months of june, july and august, compared to arteries examined during the warmer months, when there were smaller numbers ...1979518433
equine verminous arteritis. an arteriographic evaluation of the larvicidal activity of albendazole.albendazole was an effective larvicidal anthelmintic against the fourth stage strongylus vulgaris larvae as late as one month post-infection. the drug was administered at a dose rate of 25 mg/kg three times daily for 5 days. diarrhoea occurred in 3 of 4 foals treated and of these one died during belated intravenous therapy for dehydration. arteriography allowed for an in vivo assessment of the development and regression of lesions in infected-treated foals compared to the continued development o ...1979540630
anthelmintic efficiency of fenbendazole in equines.a single oral dose of fenbendazole (fbz) at 10 mg/kg body mass was given to 5 donkeys. a further 5 donkeys were dosed with a medicated lick (1 mg fbz/g lick) until the oral consumption was 10 mg/kg body mass. in both trials fbz was highly effective against adults of the following genera: cyathostomum, cylicocyclus, cylicostephanus, cylicodontophorus, poteriostomum, cabellonema, craterostomum and triodontophorus; similarly high efficiency was obtained against the following species: habronema maju ...1979553963
antiparasitic activity of parbendazole in critical tests in horses.critical tests were conducted in 11 naturally infected horses to evaluate the anthelmintic activity of parbendazole. single doses at the rates of 30, 20, 10, 5, or 2.5 mg/kg of body weight were administered by stomach tube to 1, 4, 2, 2, and 2 horses, respectively. parbendazole was active against parascaris equorum, oxyuris equi, strongylus vulgaris, strongylus edentatus, and small strongyles throughout the range of doses. generally, small numbers of p equorum were present, but apparently a dose ...19806892671
efficacy of ivermectin (22,23-dihydroavermectin b1) against gastrointestinal parasites in ponies.the controlled test method was used to evaluate the antiparasitic efficacy of im inoculated 22,23-dihydroavermectin b1 (ivermectin) against gastrointestinal parasites of horses (ponies). parasite infections were naturally acquired in southern louisiana. dose levels of the drug tested were 0.2 mg/kg, 0.3 mg/kg, and 0.5 mg/kg. ivermectin at all dose levels tested had an efficacy greater than 97% (p less than 0.05) against gasterophilus intestinalis larvae, trichostrongylus axei, oxyuris equi larva ...19806894221
anthelmintic efficiency of fenbendazole in equines.a single oral dose of fenbendazole (fbz) at 10mg/kg body mass was given to 5 donkeys. a further 5 donkeys were dosed with a medicated lick (1 mg fbz/g lick) until the oral consumption was 10mg/kg body mass. in both trials fbz was highly effective against adults of the following genera: cyathostomum, cylicocyelus, cylicostephanus, cylicodontophorus, poteriostomum, cabellonema, craterostomum and triodontophorus; similarly high efficiency was obtained against the following species: habronema majus, ...19807241490
a possible physiological uptake mechanism of methylmercury by the marine bloodworm (glycera dibranchiata). 19807357117
studies on the efficacy of fenbendazole used in a divided dosage regime against strongyle infections in ponies.the efficacy of a fenbendazole divided dose regime against immature stages of trichonema spp, strongylus vulgaris and strongylus edentatus was evaluated. a group of 8 naturally infected 30 to 36-month-old ponies was divided into 2 equal groups on the basis of previous treatment and faecal egg counts, one group being treated with 7.5 mg/kg bwt of fenbendazole daily for 5 days. this treatment regime removed 80 per cent of migrating s vulgaris larvae, 100 per cent of migrating s edentatus larvae an ...19807371614
evaluation of pyrantel pamoate, nitramisole and avermectin b1a against migrating strongylus vulgaris larvae.trials were conducted in ponies to evaluate the efficacy of pyrantel pamoate (strongid-t(r)) and two newer anthelmintics not yet commercially available, nitramisole and avermectin b(1)a, against migrating strongylus vulgaris larvae. ponies were removed from their mares within 24-48 hr after birth and reared in isolation, worm free. between six and 14 weeks of age they were infected with 2000 or 2500 infective s. vulgaris larvae. subsequently, they were monitored daily for clinical signs until th ...19807397601
equine verminous arteritis; efficiency and speed of larvicidal acitivty as influenced by dosage of albendazole.albendazole was effective in destroying strongylus vulgaris larvae in verminous lesions of the cranial mesenteric artery when administered as a 20% suspension by stomach tube to ponies. fifty mg/kg body weight administered twice a day for 2 days caused death and gradual disintegration of larvae over a period of 3 to 6 weeks with mild toxic signs appearing in 3 of 11 ponies. higher total doses of albendazole (50 mg/kg twice a day for 4 days and 25 mg/kg three times a day for 5 days) lead to more ...19807408495
anthelmintic efficacy fenbendazole paste in equines.a single oral dose of fenbendazole (fbz) paste at 7,5 mg/kg body mass was given to 5 horses. it was highly effective against adults of the following genera: cyathostomum, cylicostephanus, cylicondontophorus, poteriostomum, cylicocyclus, triodontophorus, oesophagodontus (and other genera belonging to the subfamily cyathostominae). similarly, high efficacy was obtained against the adults of the following species: oxyuris equi, strongylus vulgaris, strongylus equinus and probstmayria vivipara. thes ...19817277372
haloxon: critical tests of antiparasitic activity in equids.critical tests were conducted in 14 naturally infected equids (13 horses and 1 pony) to evaluate the antiparasitic activity of haloxon. single doses were administered by stomach tube to 3 horses and 1 pony (60 mg/kg of body weight), by addition to the feed of 3 horses (60 mg/kg), and intraorally by powder gun to 7 horses (65 mg/kg). haloxon was efficacious (99% to 100%) against infections of parascaris equorum, oxyuris equi (mature and immature), and strongylus vulgaris at both dosage levels. pr ...19817283234
tioxidazole: evaluation of antiparasitic activity of a micronized formulation in horses by the critical test method.antiparasitic activity of a micronized formulation of the benzothiazole compound, tioxidazole, at the dose rate of 11 mg/kg, was evaluated by the critical test method. drug was given by stomach to 3 horses and on feed to 3 horses. excellent removal activity was found for strongylus vulgaris (100%) in 5 naturally infected horses, s edentatus (91% to 100%) in 5 horses, small strongyles (88% to 99%) in 6 horses, immature oxyuris equi (100%) in 5 horses, and parascaris equorum (100%) in 5 horses (a ...19817283235
recovery of helminths postmortem from equines. i. parasites in arteries, subperitoneum, liver and lungs.the entire gastro-intestinal tract and viscera of the abdomen and thorax, including the heart, aorta and its branches to the viscera, are removed from the carcass. all the branches of the aorta, with the exception of the a. gastrica sinistra, are dissected from the intestinal tract, and subsequently each branch is isolated from the mesentery, fat, pancreas, kidneys, etc. usually, the a. ileocolica is grossly enlarged due to chronic arteritis with thrombus formation caused by 4th stage larvae, 4t ...19817335329
prevalence of strongylus vulgaris and parascaris equorum in kentucky thoroughbreds at necropsy.at necropsy of 49 thoroughbreds from farms with generally good parasite control programs in central kentucky, examination was specifically made for presence of strongylus vulgaris in all of the horses and of parascaris equorum in 21 of them. none of the deaths of the horses was caused by infections of internal parasites. visceral arteries were examined for specimens of s vulgaris and lesions related to migrating stages of this parasite. contents of the small intestines were examined for p equoru ...19817341597
controlled evaluation of ivermectin in shetland ponies.ivermectin was injected im into 12 yearling shetland ponies. the following reactions in percentages of parasites recovered from ponies given 200 microgram/kg or 300 microgram/kg, as compared with the parasitic population in those given the vehicle at 1 week after injection, were as follows: otobius megnini nymphs--no reduction; gasterophilus intestinalis--100% and 99.9%; g nasalis--100% and 99.9%; parascaris equorum adults--100% and 96%; strongylus vulgaris adults--100% and 100%; s edentatus adu ...19817027848
controlled tests of ivermectin against migrating strongylus vulgaris in ponies.twelve pony foals were reared worm-free and inoculated with strongylus vulgaris. on day 7 after inoculation, 6 ponies were given ivermectin im at a dose of 200 micrograms/kg of body weight and on day 28 were necropsied. ivermectin was effective in eliminating early 4th-stage s vulgaris larvae and reducing clinical signs associated with acute arteritis. after administrative ivermectin was effective against early 4th-stage strongylus vulgaris larvae in ponies when administered at 100, 300, or 800 ...19816895154
antigenic analyses of tissues and excretory and secretory products from strongylus vulgaris.rabbit antisera were prepared against veronal buffered saline extracts of l4 and l5 strongylus vulgaris, adult s. vulgaris and adult strongylus equinus retrieved from naturally infected horses. in agar gel diffusion with these antisera, adult s vulgaris and s. equinus each appeared to have at least one unique antigen; larval s. vulgaris appeared to have two species-specific and two stage-specific antigens. there were several common antigens. excretory and secretory products were collected also f ...19816804070
epidemiology of strongylus vulgaris infection of the horse in morocco.between august 1978 and july 1979 the anterior mesenteric artery and its branches were collected regularly from adult horses and examined for strongylus vulgaris larvae. the incidence of infection varied from 55 to 100% (annual mean 80%). the mean monthly number of larvae ranged form 3 to 22 with an annual overall mean of 13. the arterial infection was at its minimum in december to january, rose gradually to attain the peak in june and declined thereafter. these observations indicated that s. vu ...19817233560
ischaemic myocardial fibrosis and aortic strongylosis in the horse.the hearts and aortas of 2076 unselected horses of all ages were examined immediately after slaughter. focal zones of fibrosis, observed in the myocardium of 14.3 per cent of hearts examined, were found in both atria and ventricles and were unrelated to age. microscopically the majority of lesions involved myocardial fibre lysis and replacement fibrosis, although acute infarction was present in some cases. intramyocardial arterioles in or adjacent to the lesions exhibited occlusive arteriosclero ...19817238478
ivermectin as an antiparasitic agent in horses.ivermectin, described as 22,23-dihydroavermectin b1, was the compound chosen from the avermectin group of compounds for development as an antiparasitic agent in horses. a review of the literature indicates that parenteral administration in horses at 200 microgram/kg body mass is highly effective against the strongyles strongylus vulgaris, strongylus edentatus and triodontophorus spp., and adult and immature cyathostomes, including strains resistant to benzimidazole anthelmintics. other nematodes ...19826750120
morphologic and clinicopathologic changes following strongylus vulgaris infections of immune and nonimmune ponies. 19826125117
induction of ion-permeable channels by the venom of the fanged bloodworm glycera dibranchiata.venom from the poison glands of the polychaete annelid glycera convoluta has been reported to dramatically increase the frequency of miniature end-plate potentials at the frog and crayfish neuromuscular junctions, without causing detectable ultrastructural changes. we report here that addition of venom from the related annelid glycera dibranchiata to one side of a lipid bilayer results in the formation of ion-permeable channels in the membrane. the channel forming activity was found in the void ...19826294921
anthelmintic efficacy of ivermectin given intramuscularly in horses.the anthelmintic activity of ivermectin was evaluated in 18 female horses with naturally acquired parasitic infections. horses were treated once (im) with vehicle only (n = 6), 200 microgram/kg of body weight (n = 6), and 300 microgram/kg (n = 6). efficacy of both dosages of ivermectin was greater than 99% against gasterophilus spp, 100% against trichostrongylus axei, habronema muscae, h majus, and draschia megastoma, 98% to 99% against adult cyathostomes, 86% to 97% against 4th-stage cyathostom ...19826896407
antiparasitic effectiveness of ivermectin in the horse.by way of a controlled trial, the anthelmintic efficacies of the injectable and paste formulations of ivermectin were evaluated in the horse. treatment was given at the rate of 200 microgram/kg of body weight. regardless of formulation, 100% removals were demonstrated for strongylus vulgaris (intestinal), s edentatus, 2nd and 3rd instars of gastrophilus nasalis and g intestinalis, "small strongyles," triodontophorus serratus and t tenuicollis. adult cylicocyclus insigne populations were eliminat ...19826896610
ivermectin: activity against larval strongylus vulgaris and adult trichostrongylus axei in experimental infections in ponies.activity of ivermectin, administered im at the dosage rate of 200 micrograms/kg of body weight, was evaluated in controlled tests against migrating larvae of strongylus vulgaris and adult trichostrongylus axei in experimental infections in 6 ponies raised worm-free. ponies were given 2,190 or 2,400 infective 3rd-stage larvae of s vulgaris at 7 days before treatment and 22,000 or 22,750 infective 3rd-stage larvae of t axei at 42 or 45 days before treatment. three ponies were given ivermectin plus ...19826896612
efficacy of injectable and oral paste formulations of ivermectin against gastrointestinal parasites in ponies.a controlled test was used in ponies to compare the antiparasitic efficacy of ivermectin (22,23-dihydro-avermectin b1) in an injectable micelle solution administered im with the efficacy of the same drug in an oral paste formulation. parasite infections were naturally acquired in southern louisiana. the drug was tested in both formulations at a dosage level of 0.2 mg/kg of body weight. ivermectin in both formulations tested had an efficacy greater than 98% against gasterophilus intestinalis and ...19826896613
effectiveness of ivermectin against later 4th-stage strongylus vulgaris in ponies.twelve pony foals were reared worm-free and inoculated with strongylus vulgaris. approximately 8 weeks after they were inoculated, 6 foals were given ivermectin im at a dosage rate of 200 micrograms/kg of body weight and 6 were given a placebo. all foals were necropsied 35 days after treatment. ivermectin was 98.9% effective in eliminating later 4th-stage s vulgaris larvae located near the origin of major intestinal arteries and in reducing clinical signs and permitting resolution of lesions ass ...19826897344
a random walk model for the migration of strongylus vulgaris in the intestinal arteries of the horse.a study of the migration of fourth stage larvae of the parasite strongylus vulgaris in the intestinal arteries of the horse is presented. it is established, that the larvae migrate along the arteries in almost straight lines. it is suggested that this is primarily due to their ability to sense the curvature of the vessel wall, and not, as might have been expected, because of an ability to sense the direction of blood flow. a larva will sometimes alter its direction of motion when encountering a ...19827067458
retropulsion-propulsion in equine large colon.the circular and longitudinal muscle coats of equine "midcolon" were found to be directly electrically coupled. they appear to act in concert, in healthy animals, as a pacemaker in the area of the large colon pelvic flexure, for retropulsive-propulsive myoelectrical events. the retropulsive events keep the cecum and right ventral and left ventral divisions of the colon filled, imposing a delay time for fermentation of cellulose and for bacterial protein synthesis. point-to-point involvement of a ...19827073054
controlled tests of fenbendazole against migrating strongylus vulgaris in ponies.sixteen pony foals were reared worm-free and inoculated with strongylus vulgaris. on day 7 after inoculation, 12 ponies were given a fenbendazole 10% suspension at dose rate of 50 mg/kg of body weight by stomach tube. on day 8 after inoculation, 8 of these ponies were given the 2nd treatment of the anthelmintic and on day 9, 4 of these ponies were given the 3rd treatment. (the other 4 of the 16 ponies were given only tap water, as controls.) the ponies were necropsied at death or on day 28 after ...19827073073
effect of diethylcarbamazine on strongylus vulgaris infection in ponies.shetland ponies (n = 4) were given diethylcarbamazine orally at a dose level of 22 mg/kg/day for 1 week before they were inoculated with 800 third-stage larvae of strongylus vulgaris. treatment was continued for 86 (1 pony) or 200 days (3 ponies) after the inoculation. as compared with the changes seen in a similarly inoculated group of ponies (group 2) which were not treated, diethylcarbamazine did not prevent the clinical or pathologic changes due to the migrating larvae. fewer adult parasites ...19827091831
irradiated larval vaccination of ponies against strongylus vulgaris.nonimmune pony foals 9 to 12 mo of age were vaccinated with third-stage strongylus vulgaris larvae (l3) irradiated with 70, 100, or 130 kr of gamma radiation. ponies receiving per os inoculations of l3 irradiated with 70 or 100 kr were protected from the clinical disease and lesions associated with challenge infections of 4,300 l3, when compared to nonvaccinated controls. similarly, the numbers of worms from the challenging population recovered from successfully vaccinated animals were significa ...19827119986
verminous aneurysm caused by filaria.aneurysms caused by atherosclerosis are relatively frequent, as a consequence of the high incidence of this degenerative disease of the arteries. other types of aneurysm, for example, those of infectious etiology, are more uncommon. bacterias and fungi are able to cause aneurysms in several parts of the arterial tree. stengel et al (1943), in a review of world literature described 217 cases of mycotic aneurysms. the stedman's medical dictionary refers to a special type of aneurysm observed in ho ...19836346961
antibody responses of ponies to initial and challenge infections of strongylus vulgaris.an indirect fluorescent antibody assay (ifa) was developed using strongylus vulgaris third stage larvae (l3) as antigens. observations using the ifa indicate that a species-specific antibody response to s. vulgaris l3 develops in s. vulgaris-infected ponies and that some surface l3 antigens are shared by adult worms. sequential antibody levels against s. vulgaris were measured in strongyle-naive and in immune ponies following initial and challenge infections using the ifa and an indirect hemaggl ...19836351415
effectiveness of fenbendazole against later 4th-stage strongylus vulgaris in ponies.twelve pony foals (reared worm-free) were inoculated with strongylus vulgaris. approximately 8 weeks later, 4 of the foals were given fenbendazole (10% suspension) at a dosage rate of 10 mg/kg of body weight daily for 5 days and 4 foals were given the suspension at a dosage rate of 50 mg/kg daily for 3 days; the remaining foals were given a placebo. all treatments were administered by stomach tube. fenbendazole was 99.6 and 97.9% effective in the 2 treatment groups, respectively, in eliminating ...19836362499
cambendazole for strongyle control in a pony band: selection of a drug-resistant population of small strongyles and teratologic implications.cambendazole (cbz) treatments (20 mg/kg) given at 8-week intervals were used for parasite control in a breeding band of ponies (n = 33 to 43) during the period july 1974 to august 1978. pre- and posttreatment worm egg counts on feces were used to evaluate efficacy of treatments after every 2nd treatment interval by monitoring changes in strongyle egg counts. initially, effective reductions (expressed as 92% to 96% fewer worm eggs) were lessened to 70% by the 9th treatment (18 months) and to 28% ...19836824213
parasites in kentucky thoroughbreds at necropsy: emphasis on stomach worms and tapeworms.a total of 363 thoroughbreds (62 males, 292 females, and 9 geldings), 1 to 26 years of age, were examined at necropsy for internal parasites for about a 12-month period from february 1981 through february 1982. emphasis was on examining the stomach for nematodes and the small intestine and cecum for tapeworms. parasites recovered from the stomach and infection rates were: habronema spp--immature (24%), h muscae--adult (38%), draschia megastoma--immature (13%), d megastoma--adult (62%), and trich ...19836869991
[endogenous development of strongylus vulgaris]. 19836615413
transfer of adult strongylus vulgaris via stomach tube.patent infections with strongylus vulgaris were established in 6 of 8 helminth-free ponies given 41 to 101 adult worms via nasogastric tube. the parasites were removed from the cecum and ventral colon and transferred within 1 to 2 hours of the death of the donor horses. eggs were found in the feces of the recipients in 2 or 3 days; egg counts reached maximum, 28 eggs per gram of feces, at 4 weeks after ponies were inoculated. in 6 ponies euthanatized 3 to 7 weeks after parasitic transfers were d ...19836638649
sem study of strongylus vulgaris larva-induced arteritis in the pony.this paper describes the histological and scanning electron microscopical examinations of the right colic artery of eight ponies. lesions all had large thrombi surrounding a larva or larvae, with arterial wall thickening. endothelial shape change, degeneration and loss were present. fibrin-platelet red blood cell aggregates were present on endothelial surfaces as well as on the surface of thrombi. damage to the intima appeared to produce the conditions for progressive thrombus formation.19836641682
scanning electron microscopy of strongylus spp. in zebra.the external ultrastructure of the anterior and posterior extremities of the nematodes, strongylus asini , strongylus vulgaris, strongylus equinus and strongylus edentatus, was studied with scanning electron microscopy (sem). fresh specimens of s. asini were collected from the caecum, ventral colon and vena portae of equus burchelli and equus zebra hartmannae ; s. vulgaris from the caecum, colon and arteria ileocolica of e. burchelli ; s. equinus from the ventral colon of e. z. hartmannae and s. ...19836676687
the activity of closantel as an equine antiparasitic agent.eighteen pony foals were experimentally infected with 500 third stage larvae of strongylus vulgaris at 2 weeks, and at 2, 4, 6 and 8 months after birth. for the duration of the study, all foals were kept in the same pasture with their mothers to allow natural infection with other parasites by exposure to a contaminated environment. twelve of the foals were utilized in groups of 3 and treated orally five times at two month intervals starting at one month of age with closantel at doses of 5, 10, 2 ...19836683040
critical tests in equids with fenbendazole alone or combined with piperazine: particular reference to activity on benzimidazole-resistant small strongyles.seven critical tests in equids were conducted with single doses of fenbendazole (5 mg kg-1) alone (panacur--american hoechst, somerville, nj); (2 tests with paste and 1 with suspension formulation) or in combination with piperazine (american hoechst); (40 mg base kg-1); (4 tests with paste formulation). the main purpose of the tests was evaluation of activity against benzimidazole-resistant small strongyles (cyathostomum catinatum, cyathostomum coronatum, cylicocyclus nassatus, cylicostephanus g ...19836683041
verminous (strongylus vulgaris) myelitis in a donkey.a fifth stage strongylus vulgaris migrated through the spinal cord of a 2-year-old, male donkey resulting in progressive paraparesis and then tetraplegia. a profound neutrophilic pleocytosis was detected on analysis of cerebrospinal fluid. the parasite appeared to have entered the mid-lumbar spinal cord, migrated to the cranial thoracic segments, exited, then re-entered the spinal cord a few segments craniad. it then traveled further cranially and was found in the third cervical spinal cord segm ...19846705537
benzimidazole resistance of equine strongyles: critical tests of several classes of compounds against population b strongyles from 1977 to 1981.from 1977 to 1981, critical tests were conducted on 10 horses naturally infected with population b strongyles. drugs tested were: oxibendazole (obz), 10 mg/kg of body weight (n = 1); albendazole, 10 mg/kg (n = 1); a mixture of thiabendazole (tbz), 44 mg/kg and trichlorfon, 40 mg/kg (n = 1); a mixture of tbz at 44 mg/kg with piperazine (ppz) at 55 mg of base/kg (n = 1); febantel (fbt), 6 mg/kg (n = 3), 12 mg/kg (n = 1), or 24 mg/kg (n = 1); and pyrantel (prt) pamoate, 6.6 mg of base/kg (n = 1). l ...19846731997
critical test evaluations of oxfendazole and trichlorfon: effectiveness of a paste formulation in the horse.critical tests were performed on 6 horses to evaluate the antiparasitic effectiveness of oxfendazole given in combination with trichlorfon in a paste formulation. treatments were given orally as a single dose. the rates of active ingredient administration were 2.5 and 40 mg/kg of body weight for oxfendazole and trichlorfon, respectively. the combined activities of the 2 antiparasitic compounds proved 100% efficacious in the removal of adult strongylus vulgaris, s edentatus, oxyuris equi, and par ...19846742583
the prevalence and intensity of internal parasites of horses in the u.s.a.fifty-five adult horses were necropsied over a 15-month period, and their worm burdens counted and speciated. twenty-one species of cyathostominae were recovered. ten species: cyathostomum catinatum, cylicocyclus nassatus, cylicostephanus longibursatus, cyathostomum coronatum, cylicostephanus goldi, c. calicatus, c. minutus, cylicocyclus leptostomus, c. insigne and cyathostomum pateratum, comprised 98.9% of the total cyathostome burdens. these same 10 species also demonstrated high prevalences i ...19846237483
evaluation of ivermectin against later fourth-stage strongylus vulgaris in ponies at two and five weeks after treatment.the efficacy of ivermectin against later fourth-stage strongylus vulgaris larvae was studied in pony foals at 14 and 35 days after treatment. these foals had been reared parasite-free, inoculated with 500 infective larvae and 56 days later given either ivermectin at 200 micrograms/kg or a placebo intramuscularly. at necropsy, foals were examined for lesions and larvae grossly and histologically. ivermectin was found to be highly effective (98.6%) against later fourth-stage larvae in five foals w ...19846391639
controlled tests of activity of ivermectin against natural infections of migratory large strongyles and other internal parasites of equids.four controlled tests (experiments a, b, c, and d) were conducted in naturally infected yearling equids to evaluate activity of ivermectin (0.2 mg/kg im) against migrating strongylus vulgaris and s edentatus in mesenteric arteries and ventral abdominal wall, respectively. data were also obtained on activity against other internal parasites of the gastrointestinal tract and eyeworms. the type and number of equids in the experiments were as follows: experiment a-3 ponies, 2 treated and 1 non-treat ...19846395726
haematological and biochemical values in horses naturally infected with strongylus vulgaris.the concentrations of serum proteins (beta 1, beta 2, gamma, alpha 1, alpha 2 globulins and albumin) and absolute numbers of eosinophils, neutrophils and lymphocytes were examined in 64 naturally infected horses and ponies in which the number of larvae of strongylus vulgaris in the cranial mesenteric artery and the severity of the lesion of verminous arteritis could be determined. the horses were grouped according to the number of larvae found and the severity of the arteritis. the results demon ...19846485222
the elimination of equine strongyles and hematological and pathological consequences following larvicidal doses of thiabendazole.twelve horses were divided into three groups and given various doses of a mixed species strongyle inoculum, representing light, moderate, and heavy infections. three weeks after the larval inoculations, three animals from each group were given larvicidal doses of thiabendazole (tbz) (440 mg kg-1 on two consecutive days); one animal from each group served as a non-medicated control. treatment was repeated three weeks later. one treated animal from each group was designated for long-term study; ot ...19846538363
critical tests of morantel-trichlorfon paste formulation against internal parasites of the horse.critical tests were completed on six horses to evaluate the antiparasitic activity of a paste formulation mixture of morantel citrate and trichlorfon, administered intraorally at the dose rate of 6 mg morantel base kg-1 and trichlorfon at 30 mg kg-1. aggregate average removals were: 78% for two horses infected with 2nd instar gasterophilus intestinalis; 100% for one infected with 2nd instar g. nasalis; 96% for six infected with 3rd instar g. intestinalis; 100% for four infected with 3rd instar g ...19846538366
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