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adenoviruses associated with pharyngoconjunctival fever; isolation of adenovirus type 7 & serological studies suggesting its etiological role in an epidemic in helsinki. 195713470509
[cellular lesions induced by adenovirus 7 & 7 alpha]. 195713498464
[study of the cytopathogenic action of adenovirus type 7 in cell cultures]. 195813534084
infections with adenovirus type 7 in children and their relationship to acute respiratory disease. 195913649352
association between diarrhoea and adenovirus type 7. 196013826535
an electron microscope study of the early association between two mammalian viruses and their hosts.early interaction between two animal viruses, vaccinia and adenovirus 7, which multiply readily in l strain and hela cells, respectively, was examined in both whole mount preparations and in thin sections. to observe the association at the surface, cells carrying adsorbed virus were swelled under controlled conditions and then "stained" with neutral phosphotungstate. each particle of both virus types becomes attached to the cell by several capsomeres and is then ingested by phagocytosis. within ...196213883196
epidemic occurrence of adenovirus type 7 infection in helsinki. 196214451250
[an epidemic among children caused by adenovirus type 7. i. symptoms in patients in whom the virus was isolated]. 196214453805
[an epidemic among children caused by adenovirus type 7. ii. etiologic study]. 196214453806
the isolation of adenovirus type 7 from a fatal case of pneumonia and disseminated disease. 196414100105
[familial epidemic of adenovirus type 7 disease with encephalitic and blood manifestations]. 196414135064
tests in hamsters for oncogenic quality of ordinary viruses including adenovirus type 7. 196414166581
induction by adenovirus type 7 of tumors in hamsters having the antigenic characteristics of sv40 virus. 196414243505
evidence for a possible genetic hybrid between adenovirus type 7 and sv40 viruses. 196414243506
the incorporation of sv40 material into adenovirus 7 as measured by intranuclear synthesis of sv40 tumor antigen. 196414243507
studies of oncogenicity of adenovirus type 7 virus in hamsters. 196514254534
a hospital epidemic of keratoconjunctivitis caused by adenovirus type 7 in helsinki. 196514293652
adenovirus type 7 outbreak in a kindergarten. 196514345173
influence of sv40 genome on the replication of an adenovirus-sv40 "hybrid" population.feldman, l. a. (baylor university college of medicine, houston, tex.), j. l. melnick, and f. rapp. influence of sv40 genome on the replication of an adenovirus-sv40 "hybrid" population. j. bacteriol. 90:778-782. 1965.-replication of a type 7 adenovirus-sv40 hybrid population in primary african green monkey kidney cells was accompanied by the formation of sv40 tumor antigen, adenovirus antigens, and cytopathic changes characteristic of adenovirus infection. prior infection of the cultures with sv ...196516562080
adenovirus multiplication: genetic relatedness of tumorigenic human adenovirus types 7, 12, and 18.hybridization measurements among the dna's of six weakly tumorigenic strains of human adenovirus type 7 reveal that all six strains are very closely related (83- to 110-percent nucleotide sequence homology). the dna homology between these six type 7 strains and nontumorigenic types 2 and 4 is 32 percent and 52 percent, respectively. the 10- to 20-percent homology between the type 7 dna's and those of "potent" tumorigenic types 12 and 18 indicates a very low degree of genetic relatedness. these d ...196517751853
[on two fatal cases of lung disease correlated with adenovirus type 7]. 19654285319
ependymomas produced in syrian hamsters by adenovirus 7, strain e46 ("hybrid" of adenovirus 7 and sv40). 19654285456
mixed infection of african green monkey kidney cells by adenovirus 7 and sv 40. 19654288171
tumors induced in hamsters by a strain of adenovirus type 3: sharing of tumor antigens and "neoantigens" with those produced by adenovirus type 7 tumors. 19654285931
adenovirus type 7 outbreak in a kindergarten. 19654378168
[on an intrahospital epidemic episode of acute respiratory disease due to adenovirus 7]. 196514341351
induction of neoplasia in vitro in hamster kidney tissue by adenovirus 7-sv40 "hybrid" strain (lle46). 19665327111
nucleic acid homology studies of adenovirus type 7-sv40 interactions. 19664287386
induction of neoplasia in vitro in hamster thyroid tissue by sv40 and adenovirus 7-sv40 "hybrid" (strain lle46). 19664288638
inactivation and density studies with para-adenovirus 7 (sv40-adenovirus "hybrid" population). 19664289224
biophysical evidence for linkage of adenovirus and sv40 dna's in adenovirus 7-sv40 hybrid particles. 19664291405
replication in simian cells of defective viruses in an sv40-adenovirus "hybrid" population.butel, janet s. (baylor university college of medicine, houston, tex.), and fred rapp. replication in simian cells of defective viruses in an sv40-adenovirus "hybrid" population. j. bacteriol. 91:278-284. 1966.-an sv40-adenovirus type 7 "hybrid" virus population, previously shown to contain two viruses capable of complementation in green monkey kidney (gmk) cells, has a growth cycle in gmk cells similar to that of adenovirus type 7 in the presence of sv40. extending previous preliminary results, ...19664285535
encephalitis associated with adenovirus type 7 occurring in a family outbreak. 19664285229
detection of biologically active adenovirions unable to plaque in human cells.butel, janet s. (baylor university college of medicine, houston, tex.), joseph l. melnick, and fred rapp. detection of biologically active adenovirions unable to plaque in human cells. j. bacteriol. 92:433-438. 1966.-plaque formation in green monkey kidney (gmk) cells by a defective simian virus 40-adenovirus 7 "hybrid" population (para-adenovirus 7) was enhanced by the addition of excess adenovirions. adenovirus types 2, 7, and 12 were capable of providing enhancement, although none of these vi ...196616562132
replication of adenovirus type 7 in monkey cells: a new determinant and its transfer to adenovirus type 2.a strain of human adenovirus type 7, adapted to replication in green-monkey kidney cells, requires the interaction of two particles to initiate plaque formation in the simian cells. one particle is a true adenovirion. the second, apparently defective, consists of a genome carrying amonkey-adapting component in an adenovirus capsid; this genome does not express known sv40 determinants. the addition of human adenovirus type 7 that is not adapted enhances the titer and changesconditions for plaque ...19664958853
immunofluorescent studies of the potentiation of an adenovirus-associated virus by adenovirus 7.a quantitative immunofluorescent procedure for detection of viral antigen was used to study the potentiation of aav-1 by ad.7. aav viral antigen formed only when the cells were also infected with adenovirus, and only in cell culture systems in which the adenovirus infection proceeded to completion. ad. 7 infection of agmk. cell cultures did not potentiate aav unless the ad. 7 infection was itself potentiated by sv40. dose-response studies indicated that a single aav particle and a single infecti ...19674225814
characterization of the strain of adenovirus type 7 carrying the defective monkey cell-adapting component.the strain of adenovirus type 7 carrying the defective monkey cell-adapting component (mac) has been further characterized. mac is more sensitive to inactivation by ultraviolet light than the associated adenovirus, which, in turn, is more rapidly inactivated than complete simian virus 40 (sv40). the 37% dose was 16 sec for mac, 60 sec for adenovirus, and 84 sec for sv40. filtration through membranes revealed that both mac and adenovirus were retained by 100-mmu filters. mac equilibrated in cesiu ...19674316236
transformation of simian virus 40-resistant hamster cells with an adenovirus 7-simian virus 40 hybrid.when the hamster cell lines bhk21 and nil-2 were infected at a multiplicity of 100 with the adenovirus 7-simian virus 40 (sv40) hybrid (strain lle46), sv40 t antigen was induced in 0.1 to 6% of the cells during the first 96 hr postinfection, morphological changes occurred 3 to 7 weeks later, and eventually all the cells contained sv40 t antigen, but no adeno 7 t antigen. results were similar when primary and secondary monolayer cultures of hamster embryo (he) cells were infected with the adeno 7 ...19674316243
fatal pneumonia associated with adenovirus type 7. 19674378107
[epidemics of acute diseases of the respiratory system due to adenovirus 7 in premature infants]. 19674307603
transformation of african green monkey kidney cells by irradiated adenovirus 7-simian virus 40 hybrid.the ability of adenovirus 7-simian virus 40 (sv40) hybrid (strain ll "e-46") to replicate decreased exponentially as a function of the amount of gamma-irradiation; the ability to induce sv40 and adenovirus 7 t antigen decreased at a much slower rate. nevertheless, the virus was still able to transform african green monkey kidney cells at a radiation dosage that had completely destroyed its replication ability. all transformed colonies were positive for sv40 t antigen but were negative for adenov ...19684316019
[fatal infection with adenovirus type 7. some immunological aspects]. 19684304546
variation in the oncogenic potential of human adenoviruses carrying a defective sv40 genome (para).the acquisition of the defective sv40 genome by a variety of human adenovirus serotypes by the process of transcapsidation has resulted in the addition of oncogenic potential for newborn hamsters to the previously nononcogenic adenovirus types 1, 2, 5, and 6. these serotypes have previously been grouped together by the high gc content of their dna. transcapsidation of the sv40 genome to weakly oncogenic adenovirus types 3, 14, 16, and 21 has failed to increase their oncogenic potential although ...19684294682
studies on the mechanism of enhancement of adenovirus 7 infection in african green monkey cells by simian virus 40: formation of adenovirus-specific rna. 19684295919
neonatal infection caused by adenovirus type 7. 19684296691
adenovirus type-7 t antigen: separation from hexon antigen by gel filtration. a preliminary report. 19685644206
two-dimensional immuno-osmophoresis of adenovirus type 7 antigens.a test is described in which adenovirus type 7 antigens are separated by two successive perpendicular applications of electrophoresis through agar, causing precipitin formation with cationic immune globulins. three bands produced by adenovirus cultures distinguish among hexon, fiber, and penton antigens.19695772395
oncogenic simian adenoviruses. v. recovery of infectious virus from intracranial tumor cells induced by simian adenovirus 7. 19694978896
demonstration of intranuclear t-antigen by antisera to purified adenovirus 7. 19694899206
solubilization and some properties of the erythrocyte receptor for adenovirus type 7 haemagglutinin. 19694304487
variation in properties of plaque progeny of para (defective simian papovavirus 40)-adenovirus 7.one hundred and twelve progeny from double plaque-purified clones were derived from the original para (defective simian papovavirus 40)-adenovirus 7 population. these progeny were found to differ in their oncogenic potential in newborn hamsters with progeny from 20 clones not inducing any tumors during 1 year of observation. the varying tumorigenicity of the individual clonal progeny was not related to the titer of para (particle aiding replication of adenovirus) in the inoculum. there was a per ...19694311794
variants of defective simian papovavirus 40 (para) characterized by cytoplasmic localization of simian papovavirus 40 tumor antigen.three isolates of para (particle aiding replication of adenovirus)-adenovirus 7 out of a total of 112 clonal progeny derived by two successive plaque purifications in green monkey kidney cells (gmk) were found to induce the synthesis of simian papovavirus40 (sv 40) tumor (t) antigen in the cytoplasm of infected cells. the variant viruses induced plaque formation in human embryonic kidney cells which followed one-hit kinetics. in gmk cells, plaque formation followed two-hit kinetics which convert ...19694311795
severe illnesses due to adenovirus type 7 in children. 19694318009
[adenovirus 7 endemo-epidemic in a training center for naval recruits. (results of a 12 month study)]. 19694321191
plaque formation by adenovirus 7 in human diploid cell strains. 19694389114
antigenic and oncogenic properies of a cell line derived frm a hamster brain tumor induced by simian adenovirus 7. 19694311052
the histopathology of tumors induced by para-adenovirus 7 transformed cell clones. 19704323387
adenovirus type 7--associated encephalitis. 19704329176
transformation of hamster cells by variants of para-adenovirus 7 able to induce sv40 tumor antigen in the cytoplasm. 19704318984
encephaloningitis in children associated with an adenovirus type 7 epidemic. 19704315516
quantitative characteristics of the transformation of hamster cells by para (defective simian virus 40)-adenovirus 7.an in vitro method for the quantitative measurement of transformation in hamster embryo fibroblasts by the para [defective simian virus 40 (sv40)]-adenovirus 7 hybrid has been developed. transformation by para particles followed one-hit kinetics with a ratio of 1 focus-forming unit per 250 plaque-forming units. the method of viral adsorption had a direct effect upon the total number of foci which developed but not on the quantitative aspects of this assay. a fluorescent-focus assay was developed ...19704315956
immunofluorescence of adenovirus type 7 t-antigen(s) and virion antigens in infected kb cells. 19704914466
pathogenesis of oncogenic simian adenoviruses. 8. the histopathology and ultrastructure of simian adenovirus 7-induced intracranial neoplasms. 19704987496
disruption of adenovirus type 7 by lithium iodide resulting in the release of viral deoxyribonucleic acid.adenovirus type 7 exposed to solutions of lii was progressively converted into slower sedimenting deoxyribonucleic acid (dna)-containing particles, and, ultimately, under proper conditions, dna free or almost free from protein was released from the virus. the degree of viral degradation was dependent on the time of treatment, on the temperature, and on the concentration of the reagent.19704988267
partial characterization of the complementary sites involved in the reaction between adenovirus type 7 and erythrocyte receptors. 19704991707
the fate of adenovirus type 7 deosyribonucleic acid during treatment of the virus with formamide. 19705501756
evidence for the presence of half-cystine residues in the capsid of adenovirus type 7. 197011947446
density differences between hybrid and nonhybrid particles in two adenovirus-simian virus 40 hybrid populations.the adenovirus 7-simian virus 40 hybrid virus population e46(+) was subjected to fixed-angle equilibrium density gradient centrifugation in cscl. a difference in buoyant density between the hybrid virion and its nonhybrid adenovirus 7 counterpart was noted, the hybrid virion possessing the lower buoyant density. this difference in buoyant density appeared to be accentuated in a population of adenovirus 2(+t7), a derivative of e46(+) in which the adenovirus 7-simian virus 40 genome had been trans ...197016789126
immunization with live types 7 and 4 adenovirus vaccines. i. safety, infectivity, antigenicity, and potency of adenovirus type 7 vaccine in humans. 19714330997
immunization with live types 7 and 4 adenovirus vaccines. ii. antibody response and protective effect against acute respiratory disease due to adenovirus type 7. 19714330998
an epidemic of adenovirus type-7 bronchopneumonia in bantu children. 19714322988
simian virus 40 integration site in an adenovirus 7-simian virus 40 hybrid dna molecule.the e46(+) strain of adenovirus 7 is a mixed-virus population containing defective adenoviurs 7-sv40 hybrid particles and helper, nonhybrid adenovirus 7 particles. we have applied electron microscopic mapping techniques to obtain a physical map of the genome of the hybrid particles present in e46(+)pl1, a substrain of e46(+) derived from a single two-hit plaque. dna molecules extracted from purified e46(+)pl1 virions were found to be linear duplexes, with a mean lenght of 10.9 mum. when these mo ...19714324999
components of adenovirus-simian virus 40 hybrid viruses.the dna and protein components of the adenovirus 7-simian virus (sv)40 hybrid virus "e46(+)" have been investigated. the ad.7-sv40 hybrid dna genome could be distinguished from nonhybrid ad. 7 genome on the basis of its molecular weight in an alkaline sucrose gradient. the hybrid genome could also be separated from nonhybrid adenovirus 2 dna when purified transcapsidant adenovirus 2(+t7) (ad.7-sv40 dna within an ad.2 capsid) was studied. the presence and amount of sv40 dna in the hybrid virus ge ...19714327006
[characterization of a cell strain derived from a hamster tumor induced with the hybrid para-adenovirus 7]. 19714341043
tumor induction in hamster by para(3ct)-adenovirus 7 mutant. morphology and antigenic profiles of neoplastic cells. 19714332901
variations in immunogenicity of disrupted cells prepared from an adenovirus-7 hamster tumor cell line. 19715088045
concomitant immunity in hamsters bearing syngeneic transplants of tumors induced by para-adenovirus 7, simian adenovirus 7, or 9,10-dimethylbenzanthracene. 19714325852
effect of cyclophosphamide on syngeneic transplantation of para-adenovirus-7-transformed tumor cells in hamsters. 19724660941
synthesis of viral ribonucleic acid during restricted adenovirus infection.the mechanism by which simian virus 40 converts the abortive adenovirus type 7 infection of monkey cells into an efficient lytic infection has been investigated. analysis of ribonucleic acid (rna) synthesis during unenhanced and enhanced infection of monkey cells has shown that adenovirus rna synthesized in the abortive infection contains both "early" and "late" sequences. in hybridization competition experiments, early adenovirus rna from human cells prevented the hybridization of only 20% of t ...19724342240
quantitative transformation of primate cells by para (defective sv40)-adenovirus type 7. 19724344149
nasal secretion protein responses in patients with wild-type adenovirus disease.proteins were studied in nasal secretions obtained from marine corps trainees infected with wild adenovirus type 7 both during the acute phase of illness and after recovery. illness was associated with a marked increase in the concentration of serum proteins in the secretions, and during inflammation there was no apparent barrier to the passage of large molecules (molecular weight 775,000) from the serum into the respiratory passages. at the time of virus isolation, trainees requiring hospitaliz ...19724344395
variation in oncogenic and transforming potential of para (defective sv40)-adenovirus 7. 19724335076
fatal pneumonia associated with adenovirus type 7 in three military trainees. 19724337012
[properties of the intralysosomial virus at the beginning of adenovirus 7 penetration in hela cells]. 19724626116
immunofluorescence of simian adenovirus 7 (sa7)--specific antigens in infected llc-mk 2 cells and sa7 transformed cells. 19734120930
prevention of simian virus 40 tumors by hamster fetal tissue: influence of parity status of donor females on immunogenicity of fetal tissue and on immune cell cytotoxicity.fetal tissue from primiparous hamsters prevented simian virus 40 (sv40) tumorigenesis in male hamsters, whereas fetal tissue from multiparous hamsters did not. the parity status of normal (uninoculated) hamsters also influenced the cytotoxicity of their lymphoid cells against tumor cells. lymph node cells from nonpregnant primiparous and multiparous animals were cytotoxic in microcytotoxicity tests against sv40, polyoma, and adenovirus 7 tumor cells, but were not active against control bhk cells ...19734346032
an outbreak of adenovirus type 7 infection in children in montreal.thirteen infants and children with adenovirus type 7 infection proved by virus isolation are described. high fever, cough and dyspnea were the most frequent findings; in infants under 1 year of age wheezing was common. four patients required artificial ventilation. lobar collapse, consolidation and hyperinflation were frequent radiologic findings. none of the symptoms responded to antibiotic therapy or bronchodilator drugs. three patients died (mortality rate of 23%). pathologic findings were co ...19734347082
pneumonia and massive pleural effusion associated with adenovirus type 7. 19734353074
biological and biophysical characterization of sv40 cytoplasmic t-antigen-inducing mutants of para-adenovirus 7. 19734367381
detection of viral dna sequences in adenovirus-transformed cells by in situ hybridization.cytological preparations of cells transformed by members of three groups of human adenoviruses, adenovirus 12, 7, and 2, were annealed with radioactive complementary rna (crna) (4 x 10(7) to 4.5 x 10(7) dpm/mug) prepared by copying viral dna with the escherichia coli dna-directed rna polymerase. these in situ hybridizations detected adenovirus-specific dna sequences in interphase nuclei when transformed cells were annealed with homologous viral crna, but not with heterologous viral crna. the hig ...19734586775
[study of the expression of neoplasm transplantation antigens and s antigens in hamster cells, transformed by para-adenovirus 7]. 19744375482
fever and petechiae with adenovirus type 7 infection. 19744359803
epidemic of adenovirus type 7 acute conjunctivitis in swimmers. 19744360768
membranous conjunctivitis due to adenovirus type 7 infection. 19744360848
specific fragmentation of dna of adenovirus serotypes 3, 5, 7, and 12, and adeno-simian virus 40 hybrid virus ad2+nd1 by restriction endonuclease r.ecori.the products of complete digestion of duplex dna of each of seven human adenoviruses with restriction endonuclease r. ecori ranged from two fragments for adenovirus 7 dna (ad7) to six fragments for ad12 and ad2 dna. viral serotypes from the same subgroups appeared to have related cleavage sites; ad3 dna and ad7 (cl e46-ll) dna were each cleaved into three fragments, and ad7 (cl 19) dna lacked one of the cleavage sites present in ad3 and ad7 (cl e46-ll) dna. one of the cleavage sites in ad2 dna w ...19744365324
transformation potentials of the noninfectious (defective) component in pools of adenoviruses type 12 and simian adenovirus 7.pools of adenovirus 12 and simian adenovirus 7 were separated into four or five fractions by density gradient centrifugation in cesium chloride. each fraction was analyzed for total in vitro infectivity units, total transformation activity, and for total virus particle (vp) content. two major subpopulations were separated with mean densities of 1.30 +/- 0.02 and 1.34 +/- 0.02 g/ml, respectively. virions in the 1.34 g/ml range were highly infectious (10(2) to 10(3) vp per infectivity unit) in con ...19744211167
stimulation of adenovirus replication in simian cells in the absence of a helper virus by pretreatment of the cells with iododeoxyuridine.pretreatment of african green monkey kidney cells with 50 mu g of 5'-iododeoxyruidine (iudr) per ml can modify their susceptibility to the replication of human adenovirus type 7 in the absence of simian virus 40 (sv40) although this enhancement of adenovirus replication is not as efficient as that of the helper sv40 virus. since the number of infectious centers remains unchanged after iudr pretreatment whereas the burst size of virus from each infected cell increases, the iudr appears to allow e ...1975163353
adenovirus-transformed cells restrict herpes simplex virus replication.a cell line that normally supports the replication of herpes simplex virus types 1 and 2 became resistant to these viruses after transformation by simian adenovirus 7. kinetic studies of the mechanism of resistance demonstrated that both herpesviruses were able to attach to the transformed cells and express some early genomic functions, as demonstrated by the presence of low levels of viral thymidine kinase. however, isopycnic centrifugation studies of the abortive system failed to detect viral ...1975163798
spleen cell-mediated cytotoxicity of hamster cells transformed by herpes simplex virus: evidence for virus-specific membrane antigen.the nature of the host's immune response to isografts of hamster embryo fibroblasts (hef) transformed by herpes simplex virus type 1 (hsv-1) was investigated by the microcytotoxicity assay. it was found that spleen cells from tumor-bearing hamsters killed homologous tumor cells but not hef transformed by cytomegalovirus or para-(defective sv40)-adenovirus 7 (para-7). cytotoxicity was lost as the tumor increased in size. spleen cells from animals bearing isografts of hsv type 2 (hsv-2) transforme ...1975163859
letter: petechiae: due to adenovirus type 7 infection or to acetylsalicylic acid therapy? 1975165451
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