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herpesvirus saimiri. i. further characterization studies of a new virus from the squirrel monkey. 19694240128
herpesvirus saimiri. ii. experimentally induced malignant lymphoma in primates. 19694240129
lethal reticuloproliferative disease induced in cebus albifrons monkeys by herpesvirus saimiri. 19704321016
herpesvirus saimiri. v. further evidence to consider this virus as the etiological agent of a lethal disease in primates which resembles a malignant lymphoma. 19704328187
herpesvirus saimiri induced malignant lymphoma: recovery of the viral agent from the fatally affected animals. 19705006226
morphology of a disease with features of malignant lymphoma in marmosets and owl monkeys inoculated with herpesvirus saimiri. 197011515087
acute lymphocytic leukemia in owl monkeys inoculated with herpesvirus saimiri.our study demonstrates for the first time that herpesvirus saimiri can induce acute lymphocytic leukemia in owl monkeys (aotus trivirgatus) and that malignant lymphoma can be induced in this species of nonhuman primates by the inoculation of the virus by various routes (intravenous, sub-cutaneous, and intradermal).19715544872
propagation of herpesvirus saimiri in human cells. 19715570118
herpesvirus saimiri. 3. plaque formation under multi agar, methyl cellulose and starch overlays. 19714995139
morphological studies on herpesvirus saimiri in subhuman and human cell cultures. 19714997845
oncogenicity of herpesvirus saimiri in marmoset monkeys. 19715001259
malignant lymphoma with lymphocytic leukemia induced in owl monkeys by herpesvirus saimiri. 19714328952
lymphoid cell-culture line derived from lymph node of marmoset infected wtih herpesvirus saimiri--preliminary report. 19714333725
herpesvirus saimiri: in vitro sensitivity to virus-induced interferon and to polyriboinosinic acid: polyribocytidylic acid. 19714324740
the effect of polyinosinic: polycytidylic acid on fluorescent and neutralizing antibodies to herpesvirus saimiri in goats. 19714104422
intracellular and membrane immunofluorescence investigations on cells infected with herpesvirus saimiri. 19724119498
herpesvirus saimiri in marmoset-mouse hybrid cell lines. 19724627749
malignant lymphoma induced by partially purified herpesvirus saimiri and recovery of infectious virus from tumorous lymph nodes. 19724629844
chimerism in lymphoid cell culture line derived from lymph node of marmoset infected with herpesvirus saimiri. 19724333772
isolation of herpesvirus saimiri from blood of squirrel monkeys (saimiri sciureus). 19724337913
the ultrastructure of herpesvirus saimiri-induced lymphoma in cotton-topped marmosets (saguinus oedipus). 19724337972
burkitt's lymphoma and herpesvirus saimiri lymphoma: comparative aspects. 19724338770
certain characteristics of herpesvirus saimiri cultured in subhuman primate culture cells. 19724340056
demonstration of herpesvirus saimiri-associated antigens in peripheral lymphocytes from infected marmosets during in vitro cultivation. 19724347039
effect of cytosine arabinoside, adenine arabinoside, tilorone, and rifamycin sv on multiplication of herpesvirus saimiri in vitro.the multiplication of herpesvirus saimiri was inhibited in vitro by cytosine arabinoside, adenine arabinoside, and tilorone, but not by rifamycin sv.19724670435
herpesvirus saimiri malignant lymphoma in spider monkeys. a new susceptible host. 19724680380
spontaneous herpesvirus saimiri lymphoma in an owl monkey. 19734350520
herpesvirus saimiri: experimental infection of squirrel monkeys (saimir sciureus). 19734352746
nonimmune rosette formation by lymphoma and leukemia cells from herpesvirus saimiri-infected owl monkeys. 19734355224
antibody patterns to herpesvirus saimiri-induced antigens in owl monkeys. 19734358150
oral excretion of herpesvirus saimiri in captive squirrel monkeys and incidence of infection in feral squirrel monkeys. 19734358154
purification of herpesvirus saimiri dna. 19734360176
herpesvirus saimiri antigens and virus recovery from cultured cells and antibody levels and virus isolations from squirrel monkeys. 19734632094
induction of lymphoma in owl monkeys with heated, non-cytopathogenic herpesvirus saimiri. 19734632528
herpesvirus saimiri: enhancement of adenovirus-associated virus. 19734632584
susceptibility to herpesvirus saimiri and antibody development in old and new world monkeys. 19734632986
transplantation and cytogenetic studies of herpesvirus saimiri-induced disease in marmoset monkeys. 19734633909
lymphoma induction and viral isolation from owl monkey (aotus trivirgatus) inoculated with lymphoma cells induced by herpesvirus saimiri. 19734634067
antibody reactions to herpesvirus saimiri (hvs)-induced early and late antigens (ea and la) in hvs-infected squirrel, marmoset and owl monkeys. 19734133586
herpesvirus saimiri: a simian counterpart of epstein-barr virus of man? 19734130398
unusual intranuclear tubular structures associated with the maturation of herpesvirus saimiri in monkey kidney cell cultures. 19734198465
brief communication: a continuous in vitro source of herpesvirus saimiri. 19734200595
microtissue culture plaque assay for herpesvirus saimiri.a microtissue culture method for the plaque assay of herpesvirus saimiri has been developed. virus titrations carried out in microtest ii tissue culture plates (falcon) yielded reproducible results that agreed well with those obtained by employing macrocultures. the described method is quantitative, reproducible, economical, and suitable for routine assay of large numbers of virus samples.19734201642
characteristics of herpesvirus saimiri-induced lymphoma cells in tissue culture. 19734202510
purification and properties of herpesvirus saimiri dna. 19744206976
in vitro immunological characteristics of lymphoid cells derived from owl monkeys infected with herpesvirus saimiri. 19744209326
immunological and virological investigations on owl monkeys infected with herpesvirus saimiri. 19744209327
chemotherapy of herpesvirus saimiri induced lymphoma-leukemia in the owl monkey. 19744209328
lymphoma in owl monkeys (aotus trivirgatus) inoculated with herpesvirus saimiri: clinical, hematologic and pathologic findings. 19744209602
dna polymerase activities in vero cells infected with herpesvirus saimiri. 19744210997
evaluation of effects of cytosine arabinoside on herpesvirus saimiri replication in owl monkey kidney cells. 19744211993
prevention of lymphoma in cotton-top marmosets by herpesvirus saimiri antiserum. 19744213842
rna-dependent dna polymerase associated with a simian lymphoid cell line derived from a herpesvirus saimiri-induced lymphoma. 19744131858
morphological studies of herpesvirus saimiri in primate cell cultures. 19744134550
virological investigations of herpesvirus saimiri-infected owl monkeys. 19744134793
stimulation of herpesvirus saimiri expression in the absence of evidence for type c virus activation in a marmoset lymphoid cell line.nucleic acid base analogues were used to examine a herpesvirus saimiri (hvs)-infected marmoset lymphoid cell line (mlc-1) for possible association with type c viruses. synthetic templates poly(ra).d(pt)(10) and poly(da).d(pt)(10) were used to detect rna-directed dna polymerase activity in 100-fold concentrated tissue culture fluids. hvs was monitored by immunofluorescence for early, late, and membrane antigens. mlc-1 cells were exposed to 30 mug of 5-bromo-2'-deoxyuridine (budr) per ml for 24 h ...19744138895
herpesvirus saimiri: viability in four species of hematophagous insects and attempted insect transmission to marmosets. 19744151589
studies on experimental lymphoma induced by herpesvirus saimiri in nonhuman primates. introduction to the symposium. 19744365481
animal models: herpesvirus saimiri, a nonhuman primate model for herpesvirus-associated neoplasia of man. 19744366994
a procedure for the isolation of herpesvirus saimiri lymphocyte-associated viruses and blood parasites from monkeys living in the wild. 19744375198
herpesvirus saimiri: vii. induction of malignant lymphoma in new zealand white rabbits. 19744530878
inactivation of herpes simplex virus by thiosemicarbazones and certain cations.we demonstrated that herpes simplex virus types 1 and 2, including a type 2 strain which transforms hamster cells in vitro, and herpesvirus saimiri are inactivated by exposure to thiosemicarbazones. because thiosemicarbazones are thought to interact with heavy metals in this inactivation process (9), we tested and found some of these herpesviruses to be susceptible to exposure to certain heavy metals. a virion polymerase was sought because the ribonucleic acid (rna)-dependent deoxyribonucleic ac ...197415825395
spontaneous lymphoma associated with herpesvirus saimiri in owl monkeys.two cases of lymphoma and one case of lymphoproliferative disease were found in a group of 7 owl monkeys imported into our colony as a single group. herpesvirus saimiri (hvs) was isolated from the tumor cells of 1 lymphoma by cocultivation and from kidney cell cultures from the monkey with lymphoproliferative disease. antibody to hvs was found in serum samples from 2 monkeys positive for hvs but not in the sera from the 4 clinically normal monkeys. antibody to epstein-barr virus-infected cells w ...1975163336
infection of capuchin monkeys (cebus albifrons) with herpesvirus saimiri.herpesvirus saimiri (hvs) induced persistent, clinically inapparent infections of long-term duration in capuchin monkeys (cebus albifrons). the infections were characterized by development of antibody to hvs-associated antigens and recovery of low levels of virus-genome-carrying lymphocytes in the peripheral blood. peripheral lymphocyte counts remained in low-normal to normal ranges and no physical signs of lymphoma were evident. prednisolone treatment caused immunosuppression in one monkey; thi ...1975164564
depression in lymphocyte response to general mitogens by owl monkeys infected with herpesvirus saimiri.the effect of herpesvirus saimiri (hvs) infection on the response of owl monkey lymphocytes to general mitogens was examined during the development of neoplastic disease. the reactivity of the lymphocytes was then correlated with the clinical condition of the infected monkeys and the content of virus rescued from the peripheral blood lymphocytes (pbl). eight monkeys developed lymphoma which, in six monkeys, was accompanied by lymphocytic leukemia. all animals that died of hvs-induced neoplasia c ...1975164565
effect of bacillus calmette-guérin immunization in marmosets infected experimentally with herpesvirus saimiri.eight white-lipped marmosets immunized with bcg and 3 sham-immunized marmosets were studied after inoculation with herpesvirus saimiri (hvs). bcg immunization had no significant influence on the incidence of infection by hvs, incidence of fatal malignant lymphoma, time of leukemia onset, development or titer of hvs antibodies, or average survival time. one bcg-immunized, hvs-infected marmoset failed to develop malignant lymphoma, whereas the remaining 10 hvs-infected marmosets died of malignant ...1975164566
replication of herpesvirus saimiri in cultured lymphocytes of infected owl monkeys (aotus trivirgatus). an electron microscopic and immunofluorescent study.the lymphocytes of five owl monkeys infected with herpesvirus saimiri (hvs) and three control monkeys were studied. lymphocytes were separated on ficoll-hypaque gradients, incubated in suspension cultures, and prepared for electron microscopic and immunofluorescent study at 24, 48, and 72 hours after the beginning of culture (ac). buffy coats of whole blood immediately after bleeding were also prepared for study. at the time of the study, four of the five infected monkeys had died of malignant l ...1975165331
clinicopathologic characterization of herpesvirus saimiri malignant lymphoma in new zealand white rabbits.twenty-two of 39 rabbits inoculated with herpesvirus saimiri developed malignant lymphoma and either died or were killed between 17 and 165 days after inoculation. no clinical signs were present in animals developing the disease before 46 days, but all other rabbits had a severe conjunctivitis, nasal discharge, and dyspnea resulting from a lymphocytic invasion of the ocular and nasal tissues. four rabbits developed terminal leukemia. pathologically, the disease resembled h. saimiri malignant lym ...1975166191
augmentation of lymphocyte cytotoxicity by antibody to herpesvirus saimiri associated antigens.sera from owl monkeys infected with herpesvirus saimiri (hvs) mediated antibody-dependent lymphocyte cytotoxicity (adlc) against virus-infected owl monkey kidney cells. peripheral blood lymphocytes from rhesus monkeys served as effector cells in this cytotoxic assay. adlc titers increased along with membrane immunofluorescence (mf) titers but among some sera, the adlc titers were much higher than expected from the mf titers, suggesting that multiple serum factors were involved in mediating adlc ...1975169525
spontaneous herpesvirus saimiri lymphoma in owl monkeys.three examples of spontaneous malignant lymphoma were observed in owl monkeys 23, 81, and 183 days after arrival in our laboratories. the pathological features of the disease were analogous to experimentally induced herpesvirus saimiri lymphoma. h. saimiri was recovered from 2 animals (it was not attempted from one case) and one isolate was shown to reproduce characteristic h. saimiri malignant lymphoma. each monkey originated in peru in contrast to our usual source of owl monkeys which originat ...1975169813
experiments to vaccinate marmoset monkeys against malignant lymphoma.humoral antibodies can be induced in cotton topped (ct) marmosets with killed herpesvirus saimiri (hvs) vaccines. the serum antibodies delayed, but did not prevent, malignant lymphoma in actively and passively immunized monkeys after inoculation with 10(3.8)tcid50 of cell-free hvs. experiments are in progress to determine whether the vaccines are able to protect against smaller challenge dosages of hvs. the immunized monkeys were not resistant against transplantation of tumor cells. infection wi ...1975169814
comparisons of surface markers on herpesvirus-associated lymphoid cells of nonhuman primates and established human lymphoid cell lines.herpesvirus saimiri (hvs)-owl monkey lymphoid cells were found to have high levels of surface receptor for sheep erythrocytes and erythrocytes of 3 other species. these hvs-lymphoid cells lacked a receptor for modified complement. lymphoid cells of one hvs-owl monkey line showed evidence for the presence of surface immunofluorescent staining with anti-kappa chain serum. cells of an established hvs-marmoset lymphoid line had similar surface markers. of 4 established human lymphoid cell lines, all ...1975169815
immunological control of virus-induced tumors in primates.cells infected by oncogenic viruses may transform, may develop a latent carrier state, or may be destroyed but understanding of the control of the results of infection is incomplete. even if cells transform, ultimate development of a tumor may be immunologically controlled. for example, cells of some marmoset species transform after infection with rna tumor viruses, and animals react to the transformed cells with cell-mediated and humoral immune responses. both virus specific and cross-reacting ...1975169832
nonhuman primate models for lymphoma, leukemia, and other neoplasms.herpesvirus saimiri (hvs) is an oncogenic virus for a variety of nonhuman primates. hvs does not produce overt disease upon inoculation in the natural host (squirrel monkey) but consistently induces neoplasms including lymphomas and lymphocytic leukemias in 4 other species of monkeys. various drugs inhibit replication of hvs in vitro including cytosine arabinoside and adenine arabinoside. in addition, the lymphoma and leukemia induced in owl monkeys responds to vincristine and prednisolone, cycl ...1975169836
response to primary infection with herpesvirus saimiri in immunosuppressed juvenile and newborn squirrel monkeys.immunosuppression of juvenile squirrel monkeys with combined azathioprine, prednisolone, and antilymphocyte globulin resulted in decreased antibody responses to viral antigens after primary infection with herpesvirus saimiri (hvs). the virus was repeatedly isolated from the oropharynx of immunosuppressed monkeys but not from untreated infected controls. thus immune factors are important in inhibiting shedding of hvs from the oropharynx. hvs could be isolated from the peripheral blood lymphocytes ...1975170204
the effect of an immunosuppressive drug (azathioprine) on the latent infection of marmoset monkeys (callithrix jacchus) with the oncogenic herpesvirus saimiri.callithrix jacchus (cj) marmoset monkeys can be latently infected with herpesvirus saimiri (hvs). in order to determine whether this resistance to the oncogenic potential of hvs could be due to the immune surveillance, azathioprine, a known immunosuppressive drug, was given to 7 latently infected cj marmosets. the animals died within 147 days probably from side effect caused by azathioprine, but no animal developed a tumor.1975170499
inhibition of the mitogenic response of normal peripheral lymphocytes by extracts or supernatant fluids of a herpesvirus saimiri lymphoid tumor cell line.a herpesvirus saimiri-infected marmoset lymphoid cell line (mlc-1) was examined for the presence of soluble factors which might affect lymphocyte functions and, therefore, relate to the pathogenesis of lymphoma in vivo. mlc-1 cells, cell extracts, and culture fluids were shown to reduce the spontaneous deoxyribonucleic acid (dna) synthesis of normal peripheral blood lymphocytes and to completely inhibit their response to phytohemagglutinin (pha). suppression of pha response was demonstrated agai ...1975172449
experimental horizontal transmission of herpesvirus saimiri from squirrel monkeys to an owl monkey.herpesvirus saimiri was naturally transmitted from squirrel monkeys excreting the virus to one of two owl monkeys housed in the same cage. the owl monkey became infected approximately three months after contact was initiated. h. saimiri was consistently isolated from the peripheral lymphocytes until this animal died eight months later. during this period the owl monkey developed specific antibody to h. saimiri to a maximal neutralization index of 5.5 logs. the other monkey remained uninfected fo ...1975172563
induction and in vitro demonstration of cellular immunity to dna and rna viruses in guinea-pigs.guinea-pigs were immunized with different cells infected with vaccinia virus, herpes simplex virus type 1, herpesvirus saimiri, and the virus of vesicular stomatitis. development of cellular immunity against these viruses was observed with transformation of blood and spleen lymphocytes and with the migration inhibition test using peritoneal exudate cells. cellular immunity against vaccinia virus was first seen 6 days after the inoculation of cell-bound vaccinia virus by lymphocyte transformation ...1975173485
attenuation of herpesvirus saimiri for marmosets after successive passage in cell culture at 39 degrees c.a variant of herpesvirus saimiri (hvs) stably attenuated for marmosets was isolated after serial passage of wild-type hvs in cell culture at 39 degrees c. marmosets previously inoculated with attenuated virus experienced a significant delay in the development of lymphoma when challenged with wild-type hvs.1975173864
purification of herpesvirus saimiri and properties of the viral dna.conditions for growth, concentration, and purification of herpesvirus saimiri were determined. optimal yields of infectious herpesvirus saimiri (hvs) were obtained from infected owl monkey kidney (omk) cells grown at 32.5 degrees c in medium containing 10 per cent fetal calf serum. forth-five percent of the initial infectious hvs was recovered after an 18-fold concentration using 8 per cent polyethylene glycol 6000 in the presence of 0.5 m nacl. polyethylene glycol concentrated hvs was purified ...1975174525
the role of herpesvirus saimiri genomes in oncogenic transformation of primate cells. 1975183689
correspondence between t cell suppression and adlc titers during herpesvirus saimiri (hvs) infection in owl monkeys. 1975183696
lymphocyte responsiveness in squirrel, cebus and marmoset monkeys infected with herpesvirus saimiri. 1975183704
antilymphocytic factor derived from a herpesvirus saimiri lymphoid tumor cell line. 1975183705
reactivation of squirrel monkey heart isolate (herpesvirus saimiri strain) from latently infected human cell cultures and induction of malignant lymphoma in marmoset monkeys. 1975183706
no evidence for particles encapsulating rna-instructed dna polymerase and high molecular weight virus-related rna in herpesvirus induced tumours of non-human primates.the simultaneous detection test gave no evidence for the presence of rna tumour viruses in herpesvirus induced malignant lymphomas of non-human primates. the 12 tumours tested were obtained from three different monkey species inoculated with herpesvirus saimiri or herpesvirus ateles. particles encapsulating rna-instructed dna polymerase and high mol. wt. virus-related rna were easily demonstrated in tumours of the mouse induced by type-c or type-b oncornaviruses and in human lymphoid cells infec ...197549397
evidence for suppressor cell activity associated with induction of herpesvirus saimiri-induced lymphoma.peripheral blood lymphocytes (pbl) from herpesvirus saimiri (hvs) infected owl monkeys lose their ability to respond to pha during the development of lymphoma. in this study, five hvs-infected owl monkeys were examined for their ability to respond to pha and to confer this loss of pha reactivity to normal lymphocytes. four of the monkeys developed hvs-induced disease and lost their ability to respond to pha. although less affected, reduced responses were also found with pwm. the animals which de ...1975178474
studies of the dna of herpesvirus saimiri. 1975190117
partial purification and biochemical characterization of herpesvirus saimiri.hvs propagated in vero cells was labelled with 3h-leucine and purified by isopycnic flotation in sucrose. electron microscopic examination revealed both complete and incomplete hvs. no significant contamination with cellular debris was noted. polyacrylamide gel electrophoresis analysis of solubilized virus revealed at least 12 proteins varying in molecular weight from 8 000 to 200 000 daltons.1975190128
some biological properties of herpesvirus saimiri from chronically infected monolayer and suspension cultures.hvs-mest cells, which are adherent, produced more infectious hvs at 37 degress c than at 33 degrees c. this was paralleled by the appearance of ea and la in rounded cells and cf antigen in the cell cultures. in contrast, mlc-1 cells, which grow in suspension, produced hardly any infectious virus, but did produce more hvs s antigen than did the hvs-mest cells. production of s antigen in mlc-1 cells was augmented by treatment of the cells with budr. hvs-mest cells could be superinfected with hvs, ...1975190156
ultrastructural and immunofluorescent studies of the replication of herpesvirus saimiri in cultured lymphocytes of infected owl monkeys.the lymphocytes of five owl monkeys infected with herpesvirus saimiri (hvs) and of three control owl monkeys were studied by electron microscopic (em) and immunofluorescent (if) techniques. buffy coats of whole blood immediately after bleeding were also prepared for study. at the time of the study, two of the five infected monkeys were leukaemic; within 50 days after the study, four of the five had died with malignant lymphoma and lymphocytic leukaemia. hvs virions were demonstrated by em and hv ...1975191352
induction of herpesvirus saimiri lymphoma in new zealand white rabbits inoculated intravenously. 1975191364
induction of serum antibodies in non-human primates with a killed oncogenic herpesvirus (herpesvirus saimiri). 1975191378
in vitro attenuation of herpesvirus saimiri by serial passage in dog fetal lung continuous cultures. 1975191379
repetitive sequences in complete and defective genomes of herpesvirus saimiri.two types of herpesvirus saimiri genomes can be isolated from purified virions: (i) the m genome is a double-stranded, liniear dna molecule with a mean contour length corresponding to 89 times 10-6 daltons. the m genome contains about 70% of unique sequences (light dna, 36% guanine plus cytosine) and 30% reiterated sequences (heavy dna, 71% guanine plus cytosine). (ii) the h genome is composed of heavy dna only and is more heterogeneous in size. the sequences in the h genome are up to 40-fold re ...1975803569
preferential inhibition of herpes-group viruses by phosphonoacetic acid: effect on virus dna synthesis and virus-induced dna polymerase activity. 1976960726
the owl monkey (aotus trivirgatus) as an animal model for viral diseases and oncologic studies.the owl monkey (aotus trivirgatus) has been shown to be an excellent model for studies of oncogenic and non-oncogenic viruses. studies at this institution have been primarily concerned with herpesvirus saimiri, the epstein-barr virus, h tamarinus, and h simplex. these studies have shown that h saimiri is oncogenic when inoculated into primates, that the malignancy induced by h saimiri can be naturally transmitted from the squirrel monkey to the owl monkey, that in vitro pathogenicity of h saimir ...1976190472
studies of cultured lymphocytes of the owl monkey (aotus trivirgatus) infected with herpesvirus saimiri.the lymphocytes of five owl monkeys (aotus trivirgatus) infected with herpesvirus saimiri and three control monkeys were studied. lymphocytes were separated on ficoll-hypaque gradients, incubated in suspension cultures, and prepared for electron microscopic and immunofluorescent study at 24, 48, and 72 hours after the beginning of culture. buffy coats of whole blood obtained immediately after bleeding were also prepared for study. at the time of the study, four of the five infected monkeys had d ...1976190473
immune surveillance--a powerful mechanism with a limited range.there is excellent evidence for the belief that immune surveillance mechanisms prevent the outgrowth of potentially neoplastic cells induced by horizontally transmitted, ubiquitous, potentially oncogenic viruses, indigenous to natural populations. polyoma virus in mice, marek's disease in the chicken, herpesvirus saimiri in the squirrel monkey, and the epstein-barr virus in man are examples. there is much less evidence for immune surveillance against chemically induced tumors. it is argued that ...1976193016
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