Publications

the behaviour of plasmodium berghei and plasmodium vinckei in the spiny mouse acomys cahirinus.		1961	14448536
[intraspecific and intraindividual chromosomal polymorphism in acomys minous bate (mammalia--rodentia--muridae). cytological study of acomys minous male x acomys cahirinus female hybrids. the mechanism of centric fusions].		1963	14096525
obesity and diabetes mellitus with striking congenital hyperplasia of the islets of langerhans in spiny mice (acomys cahirinus) : i. histological findings and preliminary metabolic observations.	spiny mice (acomys) are a group of small rodents indigenous to the eastern mediterranean and africa. the acomys cahirinus strain reported on here is indigenous to israel. the strain is characterized by striking and congenital hyperplasia of the islets of langerhans, primarily of the beta cells. the endocrine tissue contributes up to 15 per cent of the pancreatic mass in adults, up to 25 per cent in the newborn. pancreatic insulin content may be as high as 100 units per gram wet weight. when feda ...	1966	24173297
[the implantation time and the effect of lactation on it in acomys cahirinus dimidiatus].		1967	5583113
[obesity and diabetes mellitus in acomys cahirinus].		1967	5583112
ultrastructural studies of the hyperplastic islets of langerhans of spiny mice (acomys cahirinus) before and during the development of hyperglycemia.		1967	4907140
[the myelogenesis of a nidifugious type (acomys (cahirinus) minous, bate 1906) in comparison to a nidicolous type (albino mouse)].		1967	6053711
acanthocephala of the genus moniliformis from rodents of egypt with the description of a new species from the egyptian spiny mouse (acomys cahirinus).		1967	6066757
a breeding program for spontaneously diabetic experimental animals: psammomys obesus (sand rat) and acomys cahirinus (spiny mouse).		1968	4233365
[on the cerebralization of the nest-escaping acomys (cahirinus) minous (bate, 1906) in comparison with the nest-dwelling (albino mouse, apodemus sylvaticus (linnaeus, 1758) and albino rat). ii. morphology and allometry of postnatal brain development of acomys (cahirinus) minous, of the albino mouse, and of the albino rat].		1968	5719048
[morphological and physiological lesions in the complex syndrome of spiny mice (acomys cahirinus)].		1968	4917933
studies in spiny mice (acomys cahirinus): metabolic state and pancreatic insulin release in vitro.		1969	5407070
[differences in the white blood picture and blood glucose concentration of fed and starving spiny mice (acomys cahirinus, desmarest, 1819)].		1969	5346728
helminthic infection of cairo spiny mouse. acomys cahirinus (e. geoffroy, st. hilaire, 1803) in u.a.r.		1969	5393691
[the autonomous nervous system and the b-cell: metabolic and morphological observations made in spiny mice (acomys cahirinus) and in cultured fetal rat pancreas].		1970	4919942
interstitial nephritis in the spiny mouse (acomys cahirinus) associated with klossiella sp. infection.		1970	5005922
the kidney of spiny mice (acomys cahirinus): electron microscopy of glomerular changes associated with ageing and tubular glycogen accumulation during hyperglycemia.		1970	5432358
metabolic state, pancreatic insulin content and b-cell morphology of normoglycemie spiny mice (acomys cahirinus): indications for an impairment of insulin secretion.		1970	4914669
[obesity and diabetes mellitus in acomys cahirinus].		1971	5145545
[effect of age on the avoidance conditioning of acomys cahirinus (desmarest) (rodents, muridae)].		1971	5001914
insulin of spiny mice (acomys cahirinus)--partial characterization and evidence for two insulins.		1971	5540066
[spontaneous diabetes in a new spiny mice strain, acomys cahirinus cahirinus(desmarest 1819)].		1971	5114353
testosterone biosynthesis in the desert mouse, acomys cahirinus.		1971	4399441
[autofluorescent granules in the ependyma of the recessus inframamillaris of the yellow spiny mouse (acomys cahirinus dimidiatus)].		1972	4339918
isolation and partial structural analysis of insulin from mouse (mus musculus) and spiny mouse (acomys cahirinus).		1972	5028210
haemoglobin of the spiny mouse (acomys cahirinus) (starch gel electrophoresis, chromatographic fractionation).		1972	4636757
defective immunoreative insulin secretion in the acomys cahirinus.		1972	4343799
hyperlipidemia and impaired glucose tolerance in acomys cahirinus maintained on synthetic carbohydrate diets.		1972	5055380
adaptive responses in enzyme activities of israeli spiny mice (acomys cahirinus).		1972	5041252
androgen biosynthesis by testicular tissue of the desert rodents, acomys cahirinus and gerbillus dasyurus.		1973	4737075
seasonal observations on the cairo spiny mouse, acomys cahirinus (e. geoffroy, st. hilaire, 1803) and its fleas in egypt.		1973	4804345
recent advances in mechanism of causation of diabetes mellitus in man and acomys cahirinus.		1974	4858609
metabolic adaptation of spiny mice (acomys cahirinus) transferred from the desert to laboratory diets.		1974	4370735
evidence for decreased sensitivity to glucose of isolated islets from spiny mice. (acomys cahirinus).		1974	4375063
[electron microscope detection of biogenic amines in the medulla of the adrenal gland of the normoglycemic spiny mouse (acomys cahirinus)].	by means of a modification of the reinecke salt method already described, characteristical amine containing granules have been demonstrated in the parenchymal cells of the adrenal medulla in normoglycemic spiny mice. by this method two types of granules have been discerned according to their different contrasts. the advantages of the modification method are discussed.	1974	4377491
the effect of dietary sucrose on plasma lipids and on the liver of the spiny mouse (acomys cahirinus).		1974	4419533
olfactory imprinting resulting from brief exposure in acomys cahirinus.		1974	4414896
effects of previous exposure on olfactory discrimination in acomys cahirinus.		1974	4833517
a primacy effect for olfactory imprinting in spiny mice (acomys cahirinus.		1975	1212161
hyperlipidemia and hepatic hyperlipogenesis in spiny mice (acomys cahirinus) on carbohydrate diets: relationship to peripheral underresponsiveness and low insulin release.		1975	1167180
[the evidence of biogenic amines with reinecke-salt as a new principle of evidence of substances in the ultrahistochemistry (author's transl)].	reinecke-salt (ammonium tetracyanato diamine chromate) is known as amine precipitating reagens in applied chemistry. its amine precipitates can be demonstrated in electron micrographes. the amine reineckates are unable to diffuse and difficult to dissolve. depending from that they are localized in the cells. from our findings received in the boundary layer between adrenal cortex and adrenal medulla, we conclude that there are no non-specific precipitations with other cell components caused by re ...	1975	813480
[preliminary study of the karyotype of acomys airensis (rodentia, muridae)].		1975	1225681
retinal capillary basement membrane thickness in spiny mice (acomys cahirinus) with induced and spontaneous diabetes.	basement membrane thickness was measured in two groups of spiny mice (acomys cahirinus): one with spontaneous diabetes, the other with streptozotocin-induced diabetes. a statistical analysis of the morphometric results of the two groups showed a significant basement membrane thickening in the group with induced diabetes when compared to the spontaneously diabetic group.	1975	124711
defective insulin secretion in the spiny mouse (acomys cahirinus). possible value in the study of the pathophysiology of diabetes.		1975	169217
defective early phase insulin release in perifused isolated pancreatic islets of spiny mice (acomys cahirinus).	in order to characterize pancreatic beta cell function in geneva bred spiny mice (acomys cahirinus), the dynamics of immunoreactive insulin release were examined during perifusion of pancreatic islets isolated from normoglycemic acomys. the initial insulin response of acomys was slow: no clear-cut early (1 to 10 min) peak of insulin release was observed when glucose in the perifusion medium was abruptly raised from 2.8 mm to concentrations as high as 56 mm. this was true for islets of either you ...	1975	171800
an apparent abnormaltiy of the b-cell microtubular system in spiny mice (acomys cahirinus).	the pancreatic b-cell contains microtubules, which are thought to participate in the process of insulin release. in order to disclose a possible abnormaltiy of this b-cell microtubular system in animals with islet dysfunction, isolated islets from normal rats and mice, as well as from diabetic mutant mice (dbm mice) and from spiny mice (acomys cahirinus) were incubated in the presence of vincristine, which causes the precipitation of the microtubular protein into paracrystalline deposits. ultras ...	1975	1095441
insulin secretion in the spiny mouse (acomys cahirinus). dose and time kinetic studies with glucose in vivo and in vitro.	plasma insulin responses to the intravenous injection of glucose in the doses of 0.5, 1.5, and 3.0 gm./kg. were compared in spiny mice (acomys cahirinus) and weight-matched swiss albino mice. the mean early (two-minute) plasma insulin response was significantly lower in acomys at all doses of glucose injected; whereas, at later times (5, 15, and 30 minutes), differences in plasma insulin concentrations in the two species of mice were smaller or nonexistent. plasma glucose clearance was significa ...	1975	1104397
ultrastructure of the oocytes of the egyptian sping mouse (acomys cahirinus).	the oocytes of types 2, 3, 4 and 5 follicles from the normal spiny mouse were examined withe the electron microsome. multiple juxtanuclear golgi bodies, mitochondria associated with flattened granular endoplasmic reticulum, and large nucleus are the main features of the type 2 follicle oocyte. the numbers of mitochondria and golgi apparati increase significantly at later stages. small mitochondrial aggregates lacking "intermitochondrial cement" are seen in the ooplasm of types 3, 4 and 5 follicl ...	1975	1171638
breeding and fertility of the egyptian spiny mouse, acomys cahirinus: effect of different environments.	2 years experience with acomys in one laboratory confirmed the slow breeding rate found by other workers. on moving the animals to another laboratory there was a 2-5 fold increase in breeding rate. the most likely explanation of this change was the presence of copper in the drinking water at the 1st laboratory, due to the use of copper water pipes. the data relating to maintenance and breeding of acomys for 2 years at the 2nd laboratory were analyzed to provide a more representative picture of t ...	1976	1256010
breeding and reproduction of fifteen wild rodents maintained as laboratory colonies.	data on reproduction and production were presented for laboratory colonies of microtus pennsylvanicus tananaensis, m oeconomus macfarlani, m o operarius, m mirurus, m abbreviatus, lemmus lemmus, l sibiricus trimucronatus, dicrostonyx stevensoni, clethrionomys rutilus, peromyscus maniculatus borealis, p m bairdii, baiomys taylori, calomys ducilla, c callosus, acomys cahirinus. litter size varied from 2.0 in a cahirinus to 5.5 in c callosus. infant (neonatal) and juvenile losses through the end of ...	1976	775192
proinsulin synthesis in islets of langerhans from spiny mice (acomys cahirinus). comparison with rats and mice.	proinsulin synthesis in response to different concentrations of glucose has been studied in islets of langerhans of acomys, rat and mouse. the response to increased glucose was small in acomys when compared with rat or mouse. the time course of the effect of glucose on proinsulin synthesis was also studied in sequential 15 min periods up to 60 min. with 5.5 mm glucose the rate of 3h-leucine incorporation for acomys islets were greater over the periods 15-30, 30-45 and 45-60 min after the additio ...	1976	789163
maternal pheromone in the spiny mouse (acomys cahirinus).		1976	944929
a sensitive period for the development of olfactory preference in acomys cahirinus.		1976	996137
the verification of neurones in the pancreas of spiny mice (acomys cahirinus).	the statement that up to now no neural elements could be identified in the islets of langerhans with the aid of electron microscopy led us to reinvestigate this question of innervation of the pancreas in spiny mice using light microscopy. single nerve cells as well as nerve fibre bundles could be found in the interlobular connective tissue of the pancreas. by constrast, we could observe neither nerve cells nor nerve fibres in the islets of langerhans. extrainsular neuroinsular complexes could no ...	1976	773639
sex-differences in the agonistic behavior of spiny-mice (acomys cahirinus).	observations of 8 groups each containing three adult spiny mice (acomys cahirinus) revealed that instances of chasing and physical displacement were quite common, while fighting and biting were rarely observed. the relationships between the most frequent behavioral categories were presented in a correlation matrix. in a second study, females tested in their home cages were dominant over males. in the males' home cages, however, no differences in the frequency of female vs. male aggression were o ...	1976	944978
responses of acomys cahirinus pups to chemical cues produced by a foster species.		1977	901356
significance of anomalous thermoregulation in the pre-diabetic spiny mouse (acomys cahirinus): oxygen consumption and temperature regulation.	in keeping with studies of other desert rodents, the potentially diabetic spiny mouse has been demonstrated to have a very low basal metabolic rate, disproportionate to its body weight. the maintenance of a lower body temperature in response to high environmental temperatures and a lack of increase in metabolic rate in response to cooling have also been demonstrated. assessments of "mechanical efficiency" have shown that spiny mice carry a potential selective advantage under fasting conditions. ...	1977	603467
significance of anomalous thermoregulation in the pre-diabetic spiny mouse (acomys cahirinus): cold tolerance: blood glucose and food consumption responses to environmental heat.	decreased cold tolerance, reduced food requirement for body weight maintenance and comparative resistance to the hypoglycaemic effect of fasting in high ambient temperatures have been demonstrated in the spiny mouse. these phenomena could be related to anomalous spiny mouse thermoregulation, a phenomenon which is common in desert rodents and is simulated by mutant and artificially diabetic rodent species. the data can be interpreted as showing evidence for a survival advantage of genotypes with ...	1977	603468
dietary-dependent cross-species similarities in maternal chemical cues.	acomys cahirinus pups preferred chemical cues from conspecific lactating females maintained on the maternal diet as compared to such cues from females fed an unfamiliar diet. likewise, chemical cues from maternal diet mus musculus were preferred over those from unfamiliar diet conspecific females. thus, the production of maternal chemical stimuli may be basically similar in acomys and mus, with maternal diet being more critical than genetically programmed species-specific characteristics in dete ...	1977	11803674
temporal parameters of responsiveness to maternal pheromone in acomys cahirinus.		1978	740774
effect of diet-induced obesity on glucose and insulin tolerance of a rodent with a low insulin response (acomys cahirinus).		1979	446935
glucose production by the perfused liver of the spiny mouse (acomys cahirinus): sensitivity to glucagon and insulin.	hepatic glucose production and its responses to glucagon and insulin were studied in perfused livers obtained from spiny mice (acomys cahirinus)--rodents characterized by normoglycemia, decreased glucose tolerance and decreased insulin secretion--and from swiss albino mice. the dose-response characteristics of glucagon-induced hepatic glucose output were similar in spiny and albino mice. however, maximally stimulated glucose production were significantly lower in the spiny mouse. furthermore, th ...	1979	468520
helminths of birds and mammals of israel. viii.- skrjabinocapillaria rodentium n. sp. (nematoda capillariidae) from gerbillid and murid rodents.	skrjabinocapillaria rodentium n.sp., found in the stomach of meriones crassus, gerbillus pyramidum, g. gerbillus, g. dasyurus and acomys cahirinus, is described. it differs from the other two species in the genus, s. bakeri and s. eubursata, mainly in being larger, having a larger number of stichocytes and having a cephalic influation in the female and not in the male.	1979	485042
the reproductive tract of the male spiny mouse (acomys cahirinus) and coagulation studies with other species.	the testes of the spiny mice showed asymmetry, the left being significantly heavier than the right (p = 0.025). histological studies indicated that spermatozoa were first present in the testes of animals 35--45 days of age but the maturation of the accessory glands, especially the lateral prostates and coagulating glands, occurred later. the highest fructose concentration in the adult was in the lateral prostates (126.97 +/- 22.23 mg fructose/100 g, n = 5) and coagulating glands (99.38 +/- 17.65 ...	1979	513000
delayed or biphasic glucose-induced insulin secretion of pancreatic islets isolated from spiny mice (acomys cahirinus) : relation to age of animals.	the dynamics of insulin release from spiny mouse perifused pancreatic islets was investigated. in agreement with earlier studies we found no initial (0-10 min) insulin secretion in response to glucose in islets prepared from mice up to 35 weeks of age. the islets of animals older than 40 weeks, however, were characterized by greater insulin content, and a restored typical biphasic insulin secretion profile. the results suggest that immediate glucose response is modified by environmental or other ...	1980	6989661
accumulation of pancreas-specific products during organogenesis of acomys cahirinus.		1980	6997134
maternal behavior and the milk ejection reflex in a precocial murid (acomys cahirinus).		1980	7362595
[pyroantimonate-bound cations in the beta-cells of spiny mice pancreas (acomys cahirinus)].		1981	7032701
comparison of insulin secretion by the isolated perfused pancreas and perifused islets of the spiny mouse (acomys cahirinus).	the dynamics of glucose-stimulated insulin release were studied in the perfused pancreas and in isolated perifused islets of spiny mice. the pattern of insulin release induced by an increase of the glucose concentration from 2.8 mm to 16.7 mm was different in the two preparations. in the perfused pancreas there was an early insulin release contrasting with an absence of the early response in isolated islets. the later insulin release response (5 min to 30 min) was present and similar in both pre ...	1981	7020305
the oestrous cycle of the spiny mouse (acomys cahirinus).	the oestrous cycle of the spiny mouse (acomys cahirinus), as determined by vaginal smears, is 11.1 +/- 1.9 (s.d.) days (n = 110). the vaginal smears show cell patterns similar to those seen in the rat, but secretion of mucus is greater than in the rat. the average age at vaginal opening is 45 +/- 2.77 (s.e.m.) days, but the first litter (sired by litter mates) did not occur until 103 +/- 4.04 (s.e.m.) days. the decidual response to uterine trauma indicates tha there is an active luteal phase. th ...	1981	7193735
the response of the egyptian spiny mouse (acomys cahirinus) and two other species of commensal rodents to anticoagulant rodenticides.	the response of acomys cahirinus to three anticoagulant rodenticides was investigated in the laboratory. in contrast to the other commensal rodents rattus rattus and r. norvegicus, this species appears to be naturally very resistant to warfarin, difenacoum and brodifacoum. it is considered unlikely that anticoagulant poisons would be effective in the field for the control of a. cahirinus.	1981	7240734
experiential influences on the development of huddling preferences and "sibling" recognition in spiny mice.	the role of experience in the development of huddling preferences and sibling recognition by spiny mouse (acomys cahirinus) weanlings was investigated. in the 1st experiment, pups separated from their littermates and fostered onto unfamiliar females (and their offspring) on the day of birth, day 10, or day 20, subsequently showed preferential huddling with their foster littermates. huddling by biological siblings was as infrequent as huddling by unrelated, unfamiliar agemates. the 2nd study reve ...	1981	7250526
development of the adult pelage in normal and hormone-injected spiny mice (acomys cahirinus).	the dorsal pelage of the adult egyptian spiny mouse (acomys cahirinus) consists primarily of coarse brittle spines which differ from those of the juvenile pelage. the development of the adult pelage in juvenile spiny mice was examined in normal and estradiol- or testosterone-injected animals. females complete the development of their adult pelage significantly faster than males. both estradiol and testosterone injections speed pelage development in males. testosterone causes a significant delay ...	1981	7338723
the metabolism of cyclic amp and glucose in isolated islets from acomys cahirinus.	glucose-induced cyclic (3h) amp accumulation, insulin secretory responses and the metabolism of glucose were studied in pancreatic islets from acomys cahirinus. 27.7 mmol/l of glucose stimulated neither islet cyclic (3h) amp accumulation nor insulin release during the first 5 min of incubation. stimulation by glucose of cyclic (3h) amp was observed after 15 min of incubation and insulin release was markedly stimulated between 15 and 30 min. the utilization of glucose, measured as the production ...	1982	216600
intermediary metabolism during the development of obesity and diabetes in the desert rodent acomys cahirinus.	the spiny mouse acomys cahirinus, which exhibits beta-cell hyperplasia but low insulin secretion in captivity responded with hyperlipidemia without obesity or diabetes on a sucrose diet and became obese, and glucose-intolerant on a diet of fat-rich seeds. a three-month sucrose diet induced a marked rise in the activity of regulatory enzymes of glycolysis and lipogenesis in the liver but not in adipose tissue. there was also increased energy waste on this diet evident from a three-fold rise in th ...	1982	7118367
chromosomal phylogeny of muridae: a study of 10 genera.	the karyotypes of 10 different species of the family muridae (acomys airensis, arvicanthis niloticus, hylomyscus stella, malacomys longipes, mastomys huberti, myomys daltoni, mus musculus, rattus norvegicus, thamnomys gazellae, and uranomys ruddi) are compared by different banding techniques. from a reconstruction of the presumed ancestral karyotype of the muridae the sequence of the various rearrangements leading to the present karyotypes is proposed in order to determine their phylogenetic rel ...	1983	6617265
archicortex and neocortex in the precocial murid acomys cahirinus. a comparison with two altricial species: mus musculus and rattus norvegicus.	a morphological analysis of some structures of the archicortex and neocortex was performed in the acomys cahirinus (spiny mouse), the only precocial murid. the data obtained indicate that the spiny mouse brain is an interesting case of a largely developed hippocampus with respect to the neocortex when compared to the brains of the mouse and rat. the precocious pups of the spiny mouse present the peculiarity among murids of an early olfactory imprinting.	1983	6668122
olfactory bulb maturation in acomys cahirinus: is neural growth similar in precocial and altricial murids?	olfactory bulb maturation was assessed in the precocial murid acomys cahirinus by quantifying developmental changes in laminar volume and glomerular and mitral cell size. at the time of birth (38 days postconception), the acomys bulb is in a developmental state similar to that of altricial murids of the same gestational age. rapid growth occurs in acomys during the first 10 postnatal days with more gradual changes occurring thereafter. altricial murids also exhibit accelerated bulb development i ...	1983	6871728
enzymatic and metabolic responses to affluent diet of two diabetes-prone species of spiny mice: acomys cahirinus and acomys russatus.	the adaptive responses to sucrose and fat diets were investigated in two species of spiny mice, acomys russatus and acomys cahirinus, in relation to their propensity to develop diabetic-like symptoms. a russatus gained weight pronouncedly, both on regular and fat-rich seed diet, did not exhibit hyperglycemia or hyperlipidemia but had highly increased hepatic triglyceride content in association with high levels of circulating free fatty acids and incidence of ketonuria in 10 of 41 animals. on the ...	1983	6360745
sucrose diet induced enzymatic and hormonal responses affecting carbohydrate, lipid and energy metabolism in two species differing in insulin availability: spiny and ob/ob mice.	the low-insulin responding spiny mice (acomys cahirinus), maintained on a 50% sucrose diet vs isocaloric regular diet, responded with an impressive increase in the activity of hepatic enzymes of glycolysis and lipogenesis and in hyperlipidemia. there was no hyperinsulinemia or hyperglycemia and spiny mice did not gain weight on sucrose due to loss of adipose tissue. serum t3 levels rose 1.8 fold and the activity of the hepatic mitochondrial fad-glycerol-3-phosphate oxidase became induced 2.6 fol ...	1984	6370752
hippocampal maturation in the precocial murid rodent acomys cahirinus.	growth rates in the dentate gyrus and hippocampus proper of the precocial murid acomys cahirinus were examined by measuring age-related changes in laminar volume in 0-, 10-, 20-, and 60-day postpartum animals. a biphasic course of maturation was observed in both structures, with rapid expansion occurring in the first 10 postnatal days and more gradual growth thereafter. this pattern of growth resembles those reported for newborn altricial murids such as the laboratory mouse and rat. however, due ...	1984	6713169
brain acetylcholinesterase and its molecular forms in a precocial murid, acomys cahirinus, and rat during post-natal development.	brain acetylcholinesterase (ache) and its molecular forms of a precocial murid, acomys cahirinus, characterized by a large hippocampus, were measured during post-natal development and compared with rat. the activity of soluble ache in acomys increased slightly up to 4 weeks after birth. the total ache activity increased somewhat more but, in rats, this increase was still greater. three main molecular forms of ache were separated by 7.5% polyacrylamide gel electrophoresis. their close similarity ...	1984	6720191
response of hepatic fructokinase to long-term sucrose diets and diabetes in spiny mice, albino mice and rats.	the activity of hepatic fructokinase increased about 2-fold in desert-derived spiny mice (acomys cahirinus) and laboratory bred albino mice and rats, maintained on a 50% sucrose diet for 3 months. the role of fructose as the specific inducer was apparent, as 25% fructose diet produced activity increases similar to those of sucrose in contrast to 25% glucose diet. the activity of hexokinase was not affected by the sucrose diet, that of glucokinase rose marginally but those of pyruvate kinase and ...	1984	6088170
perinatal development of the lung in rat and spiny mouse: its relation to altricial and precocial timing of birth.	rat and spiny mouse (acomys cahirinus) are closely related murinoid species that represent altricial (rat) and precocial (spiny mouse) modes of development. the late intrauterine developmental stages of the spiny mouse therefore seem comparable to the early extrauterine developmental stages of the rat. to elucidate the question to what extent the development of the lung is related to the developmental timing of birth, we have studied some enzymes involved in the de novo synthesis of phosphatidyl ...	1984	6326867
paternal behavior in the spiny mouse (acomys cahirinus).	the responsiveness of adult male spiny mice (acomys cahirinus) to both their own and alien precocial young was investigated. paternal behavior was manifested primarily by the males huddling with their offspring and the coordination of pup attendance between adult males and females. with less than 2 days exposure to their own neonates, males were found to discriminate between their own and alien young. experience plays an important role in the development of paternal behavior in spiny mice. males ...	1984	6487216
perinatal development of the liver in rat and spiny mouse. its relation to altricial and precocial timing of birth.	rat (rattus norvegicus) and spiny mouse (acomys cahirinus) are closely related murinoid species that mainly differ in the developmental timing of birth. a comparison between the developmental profiles of some characteristic enzymes of the liver of both species was carried out to elucidate the question to what extent are these enzymic profiles and hence the maturation of the liver related to the timing of birth? it was found that these organotypic enzymes first become detectable at the same devel ...	1985	3967668
a stereological study of neocortical maturation in the precocial mouse, acomys cahirinus.	the development of neocortical area 17 of acomys cahirinus was studied by quantifying changes in the numerical density of neurons and glia, and by examinations of subjects treated on the day of birth with tritiated thymidine. unlike most laboratory species, acomys is born in a relatively advanced state, with open and functional ears and eyes and coordinated locomotor abilities. rapid neocortical growth occurred during the first 60 postnatal days and was accompanied by a 65% decrease in neuronal ...	1985	3995352
exploratory behavior of two species of murid rodents, acomys cahirinus and mus musculus: a comparative study.	the exploratory behavior of two species of murid rodents, acomys cahirinus and mus musculus, was compared in four experiments: in the first, the responses of the two species to a novel arena were studied. mus was found to take longer to enter the arena, and to spend more time in the relatively familiar or safer start box, than was acomys. the results suggest that acomys may persevere longer in exploring particular areas, whereas mus appear to explore in the open arena by using frequent shifts of ...	1985	4004686
correction of diabetic pattern of insulin release from islets of the spiny mouse (acomys cahirinus) by glucose priming in vitro.	insulin release kinetics were studied in perifused islets of langerhans, isolated from mildly hyperglycaemic and from normoglycaemic spiny mice (acomys cahirinus), a rodent predisposed to develop spontaneously non-ketotic diabetes. in both groups, insulin response to glucose (16.7 mmol/l) was delayed in comparison with that of rat islets, the release kinetics being analogous to that of human type 2 (non-insulin-dependent) diabetes. thirty min priming of the isolated acomys islets with glucose (1 ...	1985	3894135
perinatal development of the small intestine and pancreas in rat and spiny mouse. its relation to altricial and precocial timing of birth.	rat (rattus norvegicus) and spiny mouse (acomys cahirinus) are closely related species that mainly differ in the developmental timing of birth. a comparison between the developmental profiles of some characteristic enzymes of the small intestine (lactase and sucrase) and of the pancreas (amylase) of both species was carried out to elucidate the question to what extent these enzymic profiles and hence the maturation of these organs was related to the process of birth. it was found that these orga ...	1985	3921064
a comparative study of mossy fiber distribution in the brain of the precocial acomys cahirinus and of the altricial rattus norvegicus: neuroanatomical bases and behavioral correlates.	acomys cahirinus, the spiny mouse, is the only precocial murid. given the relatively advanced state of neural maturation at birth, this species is therefore of interest for comparative studies of brain and behavioural development. previous work on this species has indicated that (i) hippocampal thickness (relative to body weight) is greater in adult acomys than in rats and mice; (ii) the hippocampus appears laminated at birth, unlike that of related altricial species; (iii) the degree of olfacto ...	1985	2419270
patterns of exploratory behavior in the spiny mouse, acomys cahirinus.	the present paper reports an investigation of patterns of exploratory behavior shown by laboratory-bred spiny mice (acomys cahirinus) when given access to a large, novel arena. the aim was to test hypotheses suggested by our previous work with this species. previous experiments in which the exploratory behavior of acomys was compared with that of mus had suggested that each species had a characteristic pattern of emergence and exploration. the present experiment addressed the question of whether ...	1986	3954718
postnatal maturation of brain cholinergic systems in the precocial murid acomys cahirinus: comparison with the altricial rat.	the spiny mouse (acomys cahirinus) is the only precocial murid species. it has some neuroanatomical peculiarities such as a relatively thin cerebral cortex and a large hippocampus. the levels of choline acetyltransferase, membrane-bound acetylcholinesterase and muscarinic receptor sites (measured as [3h]quinuclidynil benzilate binding) were assessed in the whole brain on days 1, 7, 14, 21, 28 and 80 (adult), and compared with those of wistar rats of the corresponding ages. at birth choline acety ...	1986	3455597
hormones in perinatal rat and spiny mouse: relation to altricial and precocial timing of birth.	rat (rattus norvegicus) and spiny mouse (acomys cahirinus) are closely related murine species that, due to their altricial (rat) and precocial (spiny mouse) modes of development, differ in the developmental timing of birth. a comparison between the developmental profiles of plasma glucagon, insulin, thyroxine, triiodothyronine, and glucocorticosteroid hormone was carried out to elucidate the question to what extent these hormonal profiles were related to the timing of birth. although corticoster ...	1986	3524260
physical and behavioral sequelae of low birthweight in spiny mice (acomys cahirinus).	physical and behavioral sequelae of low birthweight (lbw) were investigated in spiny mice (acomys cahirinus). when raised by their biological mother, pups whose day-2 weights were 1 sd or more below the population mean remained smaller through the first 30 days postpartum than pups born within normal (n) weight ranges. lbw pups fostered onto mothers who gave birth to n pups gained weight more rapidly than lbw pups remaining with their own mother. similarly, n pups fostered onto mothers of lbw pu ...	1986	3758489
[comparative study of the brain of developed and underdeveloped neonatal rodents of the muridae family].	morphological studies have been made of the neocortical and archicortical structures in the spiny mouse acomys cahirinus, the only maturely born species from the family muridae. the data obtained reveal highly developed hippocampus as compared to the neocortex in this mouse, in contrast to relationships found in other mice and rats.	1987	3564772
opioid modulation of ingestive behaviors in the spiny mouse (acomys cahirinus).	feeding and drinking behavior were studied in deprived or sated spiny mice (acomys cahirinus) at various time intervals following peripheral administration of naloxone hydrochloride and butorphanol tartrate. naloxone attenuated both food and water intake, but not latency to respond, indicating existence of functional opioid-sensitive feeding and drinking systems in this species. butorphanol tartrate, a mixed opioid agonist/antagonist produced a dose-related enhancement or suppression of feeding, ...	1987	3613855
species differences in polysaccharide and sugar taste preferences.	this study compared the polysaccharide and sugar taste preferences of humans and four rodent species (laboratory rats, rattus norvegicus; golden syrian hamsters, mesocricetus auratus; mongolian gerbils, meriones unguiculatus; egyptian spiny mice, acomys cahirinus). in experiment 1 human subjects rated the pleasantness, sweetness, and flavor intensity of polysaccharide (polycose), sucrose, and maltose solutions at concentrations of 0.0125 m to 0.4 m, and 1% to 32% concentrations. at the higher mo ...	1987	3614791
effects of odor familiarity on the development of systematic exploration in the spiny mouse, acomys cahirinus.	developmental changes in patterns of exploration by infant spiny mice, acomys cahirinus are described. these were investigated using an unbaited radial maze and under three odor conditions; that is, animals were tested in the presence of either familiar (own) odors, unfamiliar conspecific odors, or no odors (washed floor). two hypotheses were tested. the first was based on the results of a pilot study, and was that adult animals would explore the radial maze in a systematic and predictable fashi ...	1987	3691969
[the features of the hippocampal structure as a neuroanatomical basis for differences in behavior].	neuromorphological and behavioural studies have been made on several strains of mice (c57b1, dba/2, sec) and on the spiny mouse acomys cahirinus. it was shown that animals with different genotypes differ by the size of fascia dentata and by the extension of the pyramidal layer in ca3 field of the hippocamp. animals with a higher learning capacity exhibited smaller layer of granular cells in the fascia dentata, which may be due to a lower density of neurones in this region. terminals of the mossy ...	1987	3434039